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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:diprotium oxide
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Accession:CHEBI:29375 term browser browse the term
Definition:A water that has formula H2O.
Synonyms:related_synonym: ((1)H2)water;   Formula=[1H]2O;   InChI=1S/H2O/h1H2/i/hH2;   InChIKey=XLYOFNOQVPJJNP-YOGHCVPTSA-N;   SMILES=[1H]O[1H]
 xref: CAS:7732-18-5
 xref_mesh: MESH:D014867



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diprotium oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agrp agouti related neuropeptide multiple interactions EXP [Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of AGRP mRNA; AM 251 promotes the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of AGRP mRNA] CTD PMID:26468265 NCBI chr19:33,447,992...33,481,602
Ensembl chr19:33,447,992...33,449,584
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [[Particulate Matter co-treated with Water] results in increased abundance of Metals] which results in increased expression of AKT1 mRNA CTD PMID:29335169 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Aqp1 aquaporin 1 increases transport
multiple interactions
ISO
EXP
AQP1 protein results in increased transport of Water
Mercuric Chloride inhibits the reaction [AQP1 protein results in increased transport of Water]
Mercuric Chloride inhibits the reaction [AQP1 protein results in increased transport of Water]; Mercury inhibits the reaction [AQP1 protein results in increased transport of Water]
CTD PMID:7528928 PMID:8457558 PMID:10559675 PMID:11035042 PMID:11078688 More... NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690
JBrowse link
G Aqp11 aquaporin 11 multiple interactions
increases transport
ISO Mercaptoethanol inhibits the reaction [Mercuric Chloride inhibits the reaction [AQP11 protein results in increased transport of Water]]; Mercuric Chloride inhibits the reaction [AQP11 protein results in increased transport of Water] CTD PMID:21251984 NCBI chr 1:152,046,515...152,056,675
Ensembl chr 1:152,046,517...152,056,725
JBrowse link
G Aqp2 aquaporin 2 increases expression EXP Water deficiency results in increased expression of AQP2 mRNA CTD PMID:15462210 NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) multiple interactions
increases transport
increases expression
ISO
EXP
Dexamethasone promotes the reaction [AQP3 protein results in increased transport of Water]; Mercaptoethanol inhibits the reaction [Mercuric Chloride inhibits the reaction [AQP3 protein results in increased transport of Water]]; Mercuric Chloride inhibits the reaction [AQP3 protein results in increased transport of Water]; Mercuric Chloride inhibits the reaction [Dexamethasone promotes the reaction [AQP3 protein results in increased transport of Water]]
Copper Sulfate inhibits the reaction [AQP3 protein results in increased transport of Water]; Mercuric Chloride inhibits the reaction [AQP3 protein results in increased transport of Water]
Water deficiency results in increased expression of AQP3 mRNA; Water deficiency results in increased expression of AQP3 protein
CTD PMID:9124401 PMID:9374739 PMID:15462210 PMID:22687538 NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720
JBrowse link
G Aqp4 aquaporin 4 increases transport
affects transport
increases expression
increases response to substance
EXP
ISO
AQP4 protein results in increased transport of Water
AQP4 protein affects the transport of Water
Water deficiency results in increased expression of AQP4 mRNA
AQP4 protein results in increased susceptibility to Water
CTD PMID:7528931 PMID:15462210 PMID:20815926 PMID:21251984 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
JBrowse link
G Aqp7 aquaporin 7 affects transport
increases transport
EXP AQP7 protein affects the transport of Water
AQP7 protein results in increased transport of Water
CTD PMID:9252401 PMID:18059526 NCBI chr 5:56,171,649...56,186,642
Ensembl chr 5:56,172,519...56,186,642
JBrowse link
G Aqp8 aquaporin 8 multiple interactions
affects transport
increases transport
EXP
ISO
Copper affects the reaction [AQP8 protein affects the transport of Water]; Mercury affects the reaction [AQP8 protein affects the transport of Water]
Mercuric Chloride inhibits the reaction [AQP8 protein results in increased transport of Water]
CTD PMID:18059526 PMID:19840149 NCBI chr 1:177,993,313...177,999,158
Ensembl chr 1:177,993,305...177,999,158
JBrowse link
G Aqp9 aquaporin 9 multiple interactions
affects transport
increases transport
EXP
ISO
CFTR protein promotes the reaction [AQP9 protein affects the transport of Water]; lonidamine inhibits the reaction [CFTR protein promotes the reaction [AQP9 protein affects the transport of Water]]; Mercuric Chloride inhibits the reaction [AQP9 protein results in increased transport of Water]; Mercury inhibits the reaction [AQP9 protein results in increased transport of Water]; Phloretin inhibits the reaction [AQP9 protein results in increased transport of Water]; Phloretin inhibits the reaction [CFTR protein promotes the reaction [AQP9 protein affects the transport of Water]] CTD PMID:9514918 PMID:9733774 PMID:10205677 PMID:12606488 PMID:21259319 More... NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
JBrowse link
G Avp arginine vasopressin multiple interactions EXP [Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of AVP mRNA; [Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased secretion of AVP protein; AM 251 promotes the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of AVP mRNA]; arachidonyl-2-chloroethylamide inhibits the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of AVP mRNA] CTD PMID:26468265 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [[Particulate Matter co-treated with Water] results in increased abundance of Metals] which results in increased expression of BCL2 mRNA CTD PMID:29335169 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Cartpt CART prepropeptide multiple interactions EXP [AM 251 co-treated with Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of CARTPT mRNA; [arachidonyl-2-chloroethylamide co-treated with Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of CARTPT mRNA CTD PMID:26468265 NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713
JBrowse link
G Casp1 caspase 1 multiple interactions ISO [[Particulate Matter co-treated with Water] results in increased abundance of Metals] which affects the expression of CASP1 mRNA CTD PMID:29335169 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 multiple interactions EXP [Water deficiency co-treated with Diclofenac] results in increased expression of CASP3 protein; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of CASP3 protein] CTD PMID:31042592 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions EXP
ISO
[Water deficiency co-treated with Diclofenac] results in decreased activity of CAT protein; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in decreased activity of CAT protein]
[[Particulate Matter co-treated with Water] results in increased abundance of Metals] which results in increased expression of CAT mRNA
CTD PMID:29335169 PMID:31042592 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP [Water deficiency co-treated with Diclofenac] results in increased expression of CCL2 protein; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of CCL2 protein] CTD PMID:31042592 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions EXP 1-Methyl-3-isobutylxanthine promotes the reaction [CFTR protein affects the transport of Water]; CFTR protein promotes the reaction [AQP9 protein affects the transport of Water]; lonidamine inhibits the reaction [CFTR protein promotes the reaction [AQP9 protein affects the transport of Water]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [CFTR protein affects the transport of Water]; Phloretin inhibits the reaction [CFTR protein promotes the reaction [AQP9 protein affects the transport of Water]] CTD PMID:12606488 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions EXP [Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of CNR1 mRNA; [Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of CNR1 protein CTD PMID:26468265 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions EXP [Water deficiency co-treated with Diclofenac] results in increased expression of COL3A1 protein; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of COL3A1 protein] CTD PMID:31042592 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Cr1l complement C3b/C4b receptor 1 like multiple interactions EXP [Water deficiency co-treated with Diclofenac] results in decreased expression of CR1L protein; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in decreased expression of CR1L protein] CTD PMID:31042592 NCBI chr13:106,606,952...106,660,442
Ensembl chr13:106,574,858...106,660,445
JBrowse link
G Crh corticotropin releasing hormone multiple interactions EXP [AM 251 co-treated with Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of CRH mRNA CTD PMID:26468265 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [[Particulate Matter co-treated with Water] results in increased abundance of Metals] which results in decreased expression of CYP1A1 mRNA CTD PMID:29335169 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO [[Particulate Matter co-treated with Water] results in increased abundance of Metals] which results in decreased expression of CYP2E1 mRNA CTD PMID:29335169 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Edn1 endothelin 1 affects export ISO EDN1 protein affects the export of Water CTD PMID:16340664 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression ISO Water results in increased expression of FGF2 mRNA CTD PMID:26800359 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO [[Particulate Matter co-treated with Water] results in increased abundance of Metals] which results in increased expression of GCLC mRNA CTD PMID:29335169 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO [[Particulate Matter co-treated with Water] results in increased abundance of Metals] which results in increased expression of GPX1 mRNA CTD PMID:29335169 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO [[Particulate Matter co-treated with Water] results in increased abundance of Metals] which results in increased expression of GSR mRNA CTD PMID:29335169 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hbegf heparin-binding EGF-like growth factor decreases expression ISO Water results in decreased expression of HBEGF mRNA CTD PMID:26800359 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
JBrowse link
G Hcrt hypocretin neuropeptide precursor multiple interactions EXP [Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of HCRT mRNA; AM 251 inhibits the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of HCRT mRNA] CTD PMID:26468265 NCBI chr10:85,689,979...85,691,214
Ensembl chr10:85,689,465...85,691,210
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP
ISO
Water deficiency results in increased expression of HMOX1 protein
[[Particulate Matter co-treated with Water] results in increased abundance of Metals] which results in increased expression of HMOX1 mRNA
CTD PMID:22060896 PMID:29335169 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hpgds hematopoietic prostaglandin D synthase multiple interactions ISO Water affects the reaction [Isoquinolines analog binds to and results in decreased activity of HPGDS protein] CTD PMID:22546671 NCBI chr 4:94,368,426...94,397,931
Ensembl chr 4:94,373,342...94,397,883
JBrowse link
G Il10 interleukin 10 multiple interactions EXP [Gum Arabic co-treated with Water deficiency co-treated with Diclofenac] results in increased expression of IL10 protein CTD PMID:31042592 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO
[Water deficiency co-treated with Diclofenac] results in increased expression of IL1B protein; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of IL1B protein]
[[Particulate Matter co-treated with Water] results in increased abundance of Metals] which results in increased expression of IL1B mRNA
CTD PMID:29335169 PMID:31042592 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO [[Particulate Matter co-treated with Water] results in increased abundance of Metals] which affects the expression of MT2 mRNA CTD PMID:29335169 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO [[Particulate Matter co-treated with Water] results in increased abundance of Metals] which results in increased expression of NFE2L2 mRNA CTD PMID:29335169 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO [[Particulate Matter co-treated with Water] results in increased abundance of Metals] which results in increased expression of NOS2 mRNA CTD PMID:29335169 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Npy neuropeptide Y multiple interactions EXP [AM 251 co-treated with Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of NPY mRNA CTD PMID:26468265 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [[Particulate Matter co-treated with Water] results in increased abundance of Metals] which results in increased expression of NQO1 mRNA CTD PMID:29335169 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide multiple interactions EXP [Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of OXT mRNA; [Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased secretion of OXT protein; AM 251 promotes the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of OXT mRNA]; arachidonyl-2-chloroethylamide inhibits the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of OXT mRNA]; arachidonyl-2-chloroethylamide inhibits the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased secretion of OXT protein] CTD PMID:26468265 NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490
JBrowse link
G Pmch pro-melanin-concentrating hormone multiple interactions EXP [Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of PMCH mRNA; arachidonyl-2-chloroethylamide promotes the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of PMCH mRNA] CTD PMID:26468265 NCBI chr 7:22,511,934...22,513,250
Ensembl chr 7:22,511,934...22,513,250
JBrowse link
G Pomc proopiomelanocortin multiple interactions EXP [Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of POMC mRNA; AM 251 promotes the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of POMC mRNA]; arachidonyl-2-chloroethylamide inhibits the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of POMC mRNA] CTD PMID:26468265 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Slc12a1 solute carrier family 12 member 1 multiple interactions
increases import
EXP [Glucose results in increased activity of SLC12A1 protein] which results in increased import of Water; [Mannitol results in increased activity of SLC12A1 protein] which results in increased import of Water
SLC12A1 protein results in increased import of Water
CTD PMID:12433675 NCBI chr 3:112,406,140...112,482,913
Ensembl chr 3:112,406,140...112,482,899
JBrowse link
G Slc5a3 solute carrier family 5 member 3 increases expression ISO Water deficiency results in increased expression of SLC5A3 mRNA CTD PMID:21219332 NCBI chr11:31,313,847...31,316,293
Ensembl chr11:31,295,476...31,318,883
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO [[Particulate Matter co-treated with Water] results in increased abundance of Metals] which results in increased expression of SOD1 mRNA CTD PMID:29335169 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions
ISO Water deficiency results in increased expression of SOD2 protein
[[Particulate Matter co-treated with Water] results in increased abundance of Metals] which results in increased expression of SOD2 mRNA
CTD PMID:22718889 PMID:29335169 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP TAC1 protein alternative form inhibits the reaction [Cholera Toxin results in increased secretion of Water]; TAC1 protein inhibits the reaction [Cholera Toxin results in increased secretion of Water] CTD PMID:11040190 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Water deficiency co-treated with Diclofenac] results in increased expression of TNF protein; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of TNF protein] CTD PMID:31042592 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      chemical role 19442
        greenhouse gas 12880
          water 739
            diprotium oxide 49
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    main group molecular entity 19779
                      s-block molecular entity 19617
                        hydrogen molecular entity 19604
                          hydrides 19102
                            inorganic hydride 18114
                              chalcogen hydride 2572
                                oxygen hydride 800
                                  water 739
                                    diprotium oxide 49
paths to the root