gold atom - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	gold atom	go back to main search page
Accession:	CHEBI:29287	browse the term
Definition:	A copper group element atom that has formula Au.
Synonyms:	related_synonym:	79Au; Au; Formula=Au; Gold; InChI=1S/Au; InChIKey=PCHJSUWPFVWCPO-UHFFFAOYSA-N; SMILES=[Au]; aurum; or; oro
	xref:	CAS:7440-57-5
	xref_mesh:	MESH:D006046
	xref:	WebElements:Au

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Rat (614) Mouse (622) Human (636) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (614)

gold atom

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aminoadipate-semialdehyde synthase

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of AASS mRNA
Gold analog results in decreased expression of AASS mRNA

PMID:28433809 PMID:36057382

NCBI chr 4:51,606,461...51,663,136
Ensembl chr 4:51,606,462...51,663,136

G

ATP binding cassette subfamily B member 1A

increases expression

Gold analog results in increased expression of ABCB1 mRNA

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily B member 4

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of ABCB4 mRNA
Gold analog results in decreased expression of ABCB4 mRNA

PMID:28433809 PMID:36057382

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

ATP binding cassette subfamily C member 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of ABCC1 mRNA

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 2

increases expression

Gold analog results in increased expression of ABCC2 mRNA

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of ABL1 mRNA

NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065

G

acetyl-CoA acyltransferase 1A

decreases expression

Gold analog results in decreased expression of ACAA1 mRNA

NCBI chr 8:119,079,401...119,088,626
Ensembl chr 8:119,079,775...119,088,624

G

acetyl-CoA carboxylase alpha

decreases expression

Gold analog results in decreased expression of ACACA mRNA

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

G

acyl-CoA dehydrogenase family, member 11

decreases expression

Gold analog results in decreased expression of ACAD11 mRNA

NCBI chr 8:104,681,346...104,746,559
Ensembl chr 8:104,681,396...104,746,560

G

acyl-CoA dehydrogenase medium chain

decreases expression

Gold analog results in decreased expression of ACADM mRNA

NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147

G

acyl-CoA dehydrogenase short chain

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of ACADS mRNA

NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898

G

acyl-CoA dehydrogenase, very long chain

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of ACADVL mRNA

NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075

G

aconitase 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of ACO1 mRNA

NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391

G

aconitase 2

decreases expression
multiple interactions

Gold analog results in decreased expression of ACO2 protein
[Polyethyleneimine binds to Gold] which results in increased expression of ACO2 mRNA

PMID:24780912 PMID:28433809

NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261

G

acyl-CoA oxidase 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of ACOX1 mRNA

NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232

G

acyl-CoA oxidase 2

decreases expression

Gold analog results in decreased expression of ACOX2 mRNA

NCBI chr15:16,660,584...16,692,160
Ensembl chr15:16,660,272...16,692,160

G

acid phosphatase 1

decreases expression

Gold results in decreased expression of ACP1 mRNA

NCBI chr 6:47,506,380...47,522,021
Ensembl chr 6:47,506,380...47,522,021

G

activin A receptor type 1C

decreases expression

Gold results in decreased expression of ACVR1C mRNA

NCBI chr 3:42,815,490...42,892,423
Ensembl chr 3:42,822,610...42,892,327

G

ADAM metallopeptidase domain 28

increases expression

Gold results in increased expression of ADAM28 mRNA

NCBI chr15:43,774,463...43,840,726
Ensembl chr15:42,944,467...43,840,672

G

alcohol dehydrogenase 5 (class III), chi polypeptide

decreases expression

Gold results in decreased expression of ADH5 mRNA

NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591

G

adiponectin receptor 2

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of ADIPOR2 mRNA

NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355

G

adrenoceptor alpha 1B

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of ADRA1B mRNA

NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919

G

adrenoceptor beta 2

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of ADRB2 mRNA

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

alpha-2-HS-glycoprotein

decreases expression

Gold analog results in decreased expression of AHSG mRNA

NCBI chr11:78,121,388...78,127,998
Ensembl chr11:78,117,918...78,145,999

G

apoptosis inducing factor, mitochondria associated 1

increases expression

Gold results in increased expression of AIFM1 protein

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

aminoacyl tRNA synthetase complex-interacting multifunctional protein 1

decreases expression

Gold results in decreased expression of AIMP1 mRNA

NCBI chr 2:221,151,907...221,175,458
Ensembl chr 2:221,151,904...221,175,728

G

adenylate kinase 3

decreases expression

Gold results in decreased expression of AK3 mRNA

NCBI chr 1:226,737,472...226,764,647
Ensembl chr 1:226,739,318...226,764,625

G

A-kinase anchoring protein 13

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of AKAP13 mRNA

NCBI chr 1:129,313,183...129,619,647
Ensembl chr 1:129,314,402...129,619,646

G

aldo-keto reductase family 1 member B10

increases expression

Gold results in increased expression of AKR1B10 mRNA

NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852

G

aldo-keto reductase family 1, member C2

increases expression

Gold results in increased expression of AKR1C2 mRNA

NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764

G

aldo-keto reductase family 1, member C3

increases expression

Gold results in increased expression of AKR1C3 mRNA

NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873

G

AKT serine/threonine kinase 1

multiple interactions

[Quercetin analog co-treated with Gold analog] results in decreased phosphorylation of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

albumin

multiple interactions
increases expression

ALB protein results in increased uptake of [Polyethylene Glycols binds to Gold]; ALB protein results in increased uptake of [Polyethyleneimine binds to Gold]; ALB protein results in increased uptake of [Thioctic Acid binds to Gold]
Gold analog results in increased expression of ALB mRNA

PMID:28433809 PMID:36057382

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

annexin A5

increases expression

Gold analog results in increased expression of ANXA5 protein

NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369

G

apoptotic peptidase activating factor 1

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of APAF1 mRNA; [Quercetin analog co-treated with Gold analog] results in increased expression of APAF1 protein
Gold analog results in decreased expression of APAF1 mRNA

PMID:27470402 PMID:28433809 PMID:36057382

NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540

G

apurinic/apyrimidinic endodeoxyribonuclease 1

decreases expression

Gold analog results in decreased expression of APEX1 mRNA

NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785

G

apolipoprotein A4

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of APOA4 mRNA

NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469

G

adenine phosphoribosyl transferase

decreases expression

Gold analog results in decreased expression of APRT protein

NCBI chr19:50,626,201...50,628,491
Ensembl chr19:50,626,202...50,628,431

G

aquaporin 4

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of AQP4 mRNA

NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856

G

ARF like GTPase 1

decreases expression

Gold results in decreased expression of ARL1 mRNA

NCBI chr 7:23,120,004...23,131,173
Ensembl chr 7:23,119,589...23,131,898

G

ARF like GTPase 5B

decreases expression

Gold results in decreased expression of ARL5B mRNA

NCBI chr17:77,955,864...77,979,895
Ensembl chr17:77,955,818...77,979,854

G

arylsulfatase G

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of ARSG mRNA

NCBI chr10:94,412,261...94,551,224
Ensembl chr10:94,447,399...94,542,941

G

N-acylsphingosine amidohydrolase 1

decreases expression

Gold analog results in decreased expression of ASAH1 mRNA

NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233

G

activating transcription factor 1

decreases expression

Gold results in decreased expression of ATF1 mRNA

NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670

G

activating transcription factor 4

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of ATF4 mRNA

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

activating transcription factor 6

increases cleavage

Gold analog results in increased cleavage of ATF6 protein

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase

decreases expression

Gold analog results in decreased expression of ATIC protein

NCBI chr 9:73,164,846...73,184,897
Ensembl chr 9:73,164,846...73,184,889

G

atlastin GTPase 2

decreases expression

Gold results in decreased expression of ATL2 mRNA

NCBI chr 6:15,139,071...15,180,421
Ensembl chr 6:15,139,044...15,180,421

G

ATM serine/threonine kinase

decreases expression

Gold analog results in decreased expression of ATM mRNA

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

ATPase plasma membrane Ca2+ transporting 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of ATP2B1 mRNA

NCBI chr 7:33,735,595...33,845,226
Ensembl chr 7:33,735,871...33,843,295

G

ATP synthase F1 subunit beta

multiple interactions

Gold analog results in increased expression of and results in decreased phosphorylation of ATP5F1B protein

NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273

G

ATPase H+ transporting V1 subunit G2

decreases expression

Gold analog results in decreased expression of ATP6V1G2 mRNA

NCBI chr20:3,587,681...3,591,309
Ensembl chr20:3,587,686...3,590,481

G

ATR serine/threonine kinase

decreases expression

Gold analog results in decreased expression of ATR mRNA

NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136

G

beta-secretase 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of BACE1 mRNA

NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876

G

BCL2-associated agonist of cell death

multiple interactions

[Quercetin analog co-treated with Gold analog] results in increased expression of BAD protein

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BAR/IMD domain containing adaptor protein 2

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of BAIAP2 mRNA

NCBI chr10:105,223,065...105,290,130
Ensembl chr10:105,223,090...105,290,134

G

BCL2-antagonist/killer 1

increases expression

Gold results in increased expression of BAK1 mRNA

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which affects the localization of BAX protein; [Gold analog co-treated with Platinum] results in increased expression of BAX mRNA; [Polyethyleneimine binds to Gold] which results in decreased expression of BAX mRNA; [Quercetin analog co-treated with Gold analog] results in increased expression of BAX protein
[Gold binds to NKCT1 protein, Naja kaouthia] which results in increased expression of BAX protein
Gold results in increased expression of BAX mRNA

PMID:21621595 PMID:22178767 PMID:25846798 PMID:27470402 PMID:27836789 More...

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCAS2, pre-mRNA processing factor

decreases expression

Gold results in decreased expression of BCAS2 mRNA

NCBI chr 2:190,692,503...190,700,386
Ensembl chr 2:190,692,461...190,700,389

G

BCL2, apoptosis regulator

multiple interactions

[Gold analog co-treated with Platinum] results in decreased expression of BCL2 mRNA; [Quercetin analog co-treated with Gold analog] results in decreased expression of BCL2 protein
[Gold binds to NKCT1 protein, Naja kaouthia] which results in decreased expression of BCL2 protein

PMID:25846798 PMID:27470402 PMID:27836789

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of BCL2L1 mRNA

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

Bcl2-like 11

decreases expression

Gold analog results in decreased expression of BCL2L11 mRNA

NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068

G

baculoviral IAP repeat-containing 2

decreases expression

Gold results in decreased expression of BIRC2 mRNA

NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732

G

baculoviral IAP repeat-containing 3

decreases expression

Gold analog results in decreased expression of BIRC3 mRNA; Gold results in decreased expression of BIRC3 mRNA

PMID:25523186 PMID:36057382

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

basic helix-loop-helix ARNT like 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of BMAL1 mRNA

NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231

G

BMI1 proto-oncogene, polycomb ring finger

decreases expression

Gold results in decreased expression of BMI1 mRNA

NCBI chr17:81,332,175...81,341,625
Ensembl chr17:81,332,214...81,388,690

G

BRCA1, DNA repair associated

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of BRCA1 mRNA
Gold analog results in decreased expression of BRCA1 mRNA

PMID:28433809 PMID:36057382

NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304

G

BRCA2, DNA repair associated

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of BRCA2 mRNA
Gold analog results in decreased expression of BRCA2 mRNA

PMID:28433809 PMID:36057382

NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567

G

C1D nuclear receptor corepressor

decreases expression

Gold results in decreased expression of C1D mRNA

NCBI chr14:91,660,951...91,673,177
Ensembl chr14:91,660,989...91,672,852

G

complement C3

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of C3 mRNA

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

G

similar to human chromosome 11 open reading frame 54

decreases expression

Gold results in decreased expression of C11ORF54 mRNA

NCBI chr 8:12,123,839...12,146,412
Ensembl chr 8:12,123,823...12,146,473

G

complement C9

decreases expression

Gold analog results in decreased expression of C9 mRNA

NCBI chr 2:55,573,094...55,621,345
Ensembl chr 2:55,572,992...55,621,338

G

capping actin protein of muscle Z-line subunit alpha 2

decreases expression

Gold results in decreased expression of CAPZA2 mRNA

NCBI chr 4:45,978,142...46,014,032
Ensembl chr 4:45,977,807...46,013,864

G

carbonic anhydrase 13

decreases expression

Gold results in decreased expression of CA13 mRNA

NCBI chr 2:86,928,401...86,959,525
Ensembl chr 2:86,928,383...86,959,525

G

caspase 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of CASP1 mRNA

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

multiple interactions
increases activity
increases cleavage
increases expression

[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which results in increased activity of CASP3 protein; [Gold analog co-treated with Platinum] results in increased activity of CASP3 protein; [Gold analog co-treated with Platinum] results in increased expression of CASP3 mRNA; [Polyethyleneimine binds to Gold] which results in increased expression of CASP3 mRNA; [Quercetin analog co-treated with Gold analog] results in increased cleavage of CASP3 protein; [Quercetin analog co-treated with Gold analog] results in increased expression of and results in increased activity of CASP3 protein; Dexamethasone promotes the reaction [Gold results in increased activity of CASP3 protein]; Etoposide promotes the reaction [Gold results in increased activity of CASP3 protein]
[Gold binds to NKCT1 protein, Naja kaouthia] which results in increased expression of CASP3 protein
Gold analog results in increased cleavage of CASP3 protein
Gold results in increased expression of CASP3 mRNA

PMID:19760634 PMID:21621595 PMID:22178767 PMID:25846798 PMID:26551149 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 4

increases cleavage

Gold analog results in increased cleavage of CASP4 protein

NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092

G

caspase 7

increases cleavage

Gold analog results in increased cleavage of CASP7 protein

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

increases expression
decreases expression

Gold results in increased expression of CASP8 mRNA
Gold analog results in decreased expression of CASP8 mRNA

PMID:22178767 PMID:36057382

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions
increases cleavage

[Gold analog co-treated with Platinum] results in increased activity of CASP9 protein; [Gold analog co-treated with Platinum] results in increased expression of CASP9 mRNA
Gold analog results in increased cleavage of CASP9 protein
[Gold binds to NKCT1 protein, Naja kaouthia] which results in increased expression of CASP9 protein

PMID:25846798 PMID:26551149 PMID:27836789

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

[Gold binds to NKCT1 protein, Naja kaouthia] inhibits the reaction [Diethylnitrosamine results in decreased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

chromobox 3

decreases expression

Gold results in decreased expression of CBX3 mRNA

NCBI chr 4:80,545,450...80,559,284
Ensembl chr 4:80,546,010...80,559,283
Ensembl chr 4:80,546,010...80,559,283

G

C-C motif chemokine ligand 2

multiple interactions
increases secretion

[Gold co-treated with Silicon Dioxide] results in increased secretion of CCL2 protein
Gold results in increased secretion of CCL2 protein

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 5

multiple interactions
increases secretion

[Gold co-treated with Silicon Dioxide] results in increased secretion of CCL5 protein
Gold results in increased secretion of CCL5 protein

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

C-C motif chemokine ligand 7

multiple interactions
increases secretion

[Gold co-treated with Silicon Dioxide] results in increased secretion of CCL7 protein
Gold results in increased secretion of CCL7 protein

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

G

cyclin D1

multiple interactions

[Quercetin analog co-treated with Gold analog] results in decreased expression of CCND1 protein

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

chaperonin containing TCP1 subunit 5

decreases expression

Gold analog results in decreased expression of CCT5 protein

NCBI chr 2:82,591,750...82,602,903
Ensembl chr 2:82,590,630...82,602,930

G

CD19 molecule

increases expression

Gold analog results in increased expression of CD19 mRNA

NCBI chr 1:180,987,286...180,993,920
Ensembl chr 1:180,987,286...180,993,975

G

CD36 molecule

decreases expression

Gold analog results in decreased expression of CD36 mRNA

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

CD40 molecule

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of CD40 mRNA

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

G

CD86 molecule

decreases expression

Gold analog results in decreased expression of CD86 mRNA

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

cytidine deaminase

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of CDA mRNA

NCBI chr 5:150,556,615...150,583,231
Ensembl chr 5:150,556,615...150,583,231

G

cyclin-dependent kinase 1

decreases expression
increases expression

Gold results in decreased expression of CDK1 mRNA
Gold results in increased expression of CDK1 mRNA

PMID:25523186 PMID:29705079

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin-dependent kinase 7

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of CDK7 mRNA

NCBI chr 2:31,840,558...31,865,422
Ensembl chr 2:31,840,558...31,865,383

G

cyclin-dependent kinase inhibitor 1B

multiple interactions

[Gold binds to Dimethyldithiocarbamate] which results in increased expression of CDKN1B protein

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

CDKN2A interacting protein

decreases expression

Gold results in decreased expression of CDKN2AIP mRNA

NCBI chr16:44,536,147...44,546,216
Ensembl chr16:44,536,234...44,540,033

G

cell growth regulator with ring finger domain 1

decreases expression

Gold results in decreased expression of CGRRF1 mRNA

NCBI chr15:20,088,564...20,109,042
Ensembl chr15:20,088,571...20,109,037

G

checkpoint kinase 1

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of CHEK1 mRNA
Gold analog results in decreased expression of CHEK1 mRNA

PMID:28433809 PMID:36057382

NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009

G

checkpoint kinase 2

decreases expression

Gold analog results in decreased expression of CHEK2 mRNA

NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286

G

cysteine and histidine rich domain containing 1

decreases expression

Gold results in decreased expression of CHORDC1 mRNA

NCBI chr 8:15,374,356...15,398,436
Ensembl chr 8:15,374,471...15,399,162

G

CDGSH iron sulfur domain 1

decreases expression

Gold results in decreased expression of CISD1 mRNA

NCBI chr20:17,255,302...17,268,688
Ensembl chr20:17,255,151...17,284,924

G

claudin 12

decreases expression

Gold results in decreased expression of CLDN12 mRNA

NCBI chr 4:28,522,659...28,533,647
Ensembl chr 4:28,522,678...28,533,801

G

CCHC-type zinc finger, nucleic acid binding protein

decreases expression

Gold results in decreased expression of CNBP mRNA

NCBI chr 4:120,302,768...120,311,694
Ensembl chr 4:120,302,771...120,311,637

G

CCR4-NOT transcription complex, subunit 7

decreases expression

Gold results in decreased expression of CNOT7 mRNA

NCBI chr16:51,775,416...51,794,581
Ensembl chr16:51,775,412...51,794,576

G

collagen type I alpha 1 chain

increases expression

Gold analog results in increased expression of COL1A1 protein

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type I alpha 2 chain

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of COL1A2 mRNA

NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867

G

collagen type III alpha 1 chain

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of COL3A1 mRNA

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

COMM domain containing 8

decreases expression

Gold results in decreased expression of COMMD8 mRNA

NCBI chr14:36,049,040...36,059,617
Ensembl chr14:36,049,004...36,059,617

G

cytochrome c oxidase copper chaperone COX11

decreases expression

Gold results in decreased expression of COX11 mRNA

NCBI chr10:75,458,735...75,465,322
Ensembl chr10:75,458,749...75,465,322

G

cytochrome c oxidase copper chaperone COX17

decreases expression

Gold results in decreased expression of COX17 mRNA

NCBI chr11:62,400,733...62,406,507

G

carnitine palmitoyltransferase 1A

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of CPT1A mRNA

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

carnitine palmitoyltransferase 2

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of CPT2 mRNA

NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095

G

carnitine O-octanoyltransferase

decreases expression

Gold analog results in decreased expression of CROT mRNA

NCBI chr 4:25,068,270...25,133,111
Ensembl chr 4:25,080,587...25,133,109

G

colony stimulating factor 2

multiple interactions
increases secretion

[Gold co-treated with Silicon Dioxide] results in increased secretion of CSF2 protein
Gold results in increased secretion of CSF2 protein

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

colony stimulating factor 3

increases secretion
multiple interactions

Gold results in increased secretion of CSF3 protein
[Gold co-treated with Silicon Dioxide] results in increased secretion of CSF3 protein

NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603

G

CCCTC-binding factor

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of CTCF mRNA

NCBI chr19:33,521,726...33,571,124
Ensembl chr19:33,529,319...33,571,123

G

cut-like homeobox 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of CUX1 mRNA

NCBI chr12:20,107,062...20,425,868
Ensembl chr12:20,107,311...20,425,866
Ensembl chr 4:20,107,311...20,425,866

G

C-X-C motif chemokine ligand 10

increases secretion
multiple interactions

Gold results in increased secretion of CXCL10 protein
[Gold co-treated with Silicon Dioxide] results in increased secretion of CXCL10 protein

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 2

multiple interactions
increases secretion

[Gold co-treated with Polyethylene Glycols] results in increased expression of CXCL2 mRNA; [Gold co-treated with Silicon Dioxide] results in increased secretion of CXCL2 protein
Gold results in increased secretion of CXCL2 protein

PMID:19695318 PMID:22155353

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine ligand 3

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of CXCL1 mRNA

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

cytochrome c, somatic

multiple interactions

[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which affects the localization of CYCS protein

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases activity
decreases expression
multiple interactions

Gold analog results in increased activity of CYP1A1 protein
Gold analog results in decreased expression of CYP1A1 mRNA
[Polyethyleneimine binds to Gold] which results in decreased expression of CYP1A1 mRNA

PMID:20193702 PMID:28433809 PMID:36057382

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 24, subfamily a, polypeptide 1

increases expression

Gold results in increased expression of CYP24A1 mRNA

NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383

G

cytochrome P450, family 2, subfamily d, polypeptide 4

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of CYP2D6 mRNA
Gold analog results in decreased expression of CYP2D6 mRNA

PMID:28433809 PMID:36057382

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases expression

Gold analog results in decreased expression of CYP2E1 mRNA

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450 family 7 subfamily A member 1

increases expression

Gold analog results in increased expression of CYP7A1 mRNA

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

cytohesin 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of CYTH1 mRNA

NCBI chr10:103,402,727...103,485,826
Ensembl chr10:103,366,145...103,485,760

G

DAB adaptor protein 2

increases expression

Gold results in increased expression of DAB2 mRNA

NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476

G

decapping mRNA 2

decreases expression

Gold results in decreased expression of DCP2 mRNA

NCBI chr18:36,750,732...36,787,067
Ensembl chr18:36,750,732...36,788,557

G

dopa decarboxylase

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of DDC mRNA

NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208

G

DNA-damage inducible transcript 3

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DNA-damage-inducible transcript 4

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of DDIT4 mRNA

NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105

G

defensin beta 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of DEFB1 mRNA

NCBI chr16:70,298,862...70,313,604
Ensembl chr16:70,298,863...70,313,604

G

24-dehydrocholesterol reductase

multiple interactions
decreases expression

[Gold co-treated with Polyethylene Glycols] results in decreased expression of DHCR24 mRNA
Gold analog results in decreased expression of DHCR24 mRNA
[Polyethyleneimine binds to Gold] which results in decreased expression of DHCR24 mRNA

PMID:19695318 PMID:28433809 PMID:36057382

NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137

G

dihydrolipoamide dehydrogenase

decreases expression

Gold analog results in decreased expression of DLD mRNA

NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795

G

dynein axonemal heavy chain 14

decreases expression

Gold results in decreased expression of DNAH14 mRNA

NCBI chr13:93,322,653...93,540,706
Ensembl chr13:93,322,711...93,538,646

G

DnaJ heat shock protein family (Hsp40) member A3

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of DNAJA3 mRNA

NCBI chr10:10,854,732...10,880,171
Ensembl chr10:10,854,732...10,880,161

G

DnaJ heat shock protein family (Hsp40) member B14

decreases expression

Gold results in decreased expression of DNAJB14 mRNA

NCBI chr 2:226,358,988...226,409,461
Ensembl chr 2:226,358,996...226,402,490

G

DnaJ heat shock protein family (Hsp40) member B6

decreases expression

Gold results in decreased expression of DNAJB6 mRNA

NCBI chr 4:5,452,683...5,556,679
Ensembl chr 4:5,452,683...5,556,659

G

DnaJ heat shock protein family (Hsp40) member B9

decreases expression

Gold results in decreased expression of DNAJB9 mRNA

NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063

G

DnaJ heat shock protein family (Hsp40) member C10

decreases expression

Gold results in decreased expression of DNAJC10 mRNA

NCBI chr 3:65,232,031...65,272,732
Ensembl chr 3:65,232,697...65,272,719

G

DnaJ heat shock protein family (Hsp40) member C19

decreases expression

Gold results in decreased expression of DNAJC19 mRNA

NCBI chr 2:116,923,272...116,945,312
Ensembl chr 2:116,923,272...116,945,264

G

DnaJ heat shock protein family (Hsp40) member C21

decreases expression

Gold results in decreased expression of DNAJC21 mRNA

NCBI chr 2:59,419,507...59,446,746
Ensembl chr 2:59,419,510...59,446,752

G

DnaJ heat shock protein family (Hsp40) member C5

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of DNAJC5 mRNA

NCBI chr 3:168,621,905...168,656,570
Ensembl chr 3:168,621,969...168,655,935

G

dihydropyrimidinase-like 4

increases expression

Gold analog results in increased expression of DPYSL4 mRNA

NCBI chr 1:193,883,039...193,898,916
Ensembl chr 1:193,883,106...193,898,914

G

dopamine receptor D3

multiple interactions

Gold inhibits the reaction [3-N-methylspiperone binds to DRD3 protein]

NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596

G

dopamine receptor D4

multiple interactions

Gold inhibits the reaction [3-N-methylspiperone binds to DRD4 protein]

NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553

G

desmocollin 2

increases expression

Gold results in increased expression of DSC2 mRNA

NCBI chr18:11,450,392...11,482,476
Ensembl chr18:11,450,390...11,482,392

G

desmoglein 2

increases expression

Gold results in increased expression of DSG2 mRNA

NCBI chr18:11,846,207...11,904,630
Ensembl chr18:11,846,183...11,904,156

G

dual oxidase 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of DUOX1 mRNA

NCBI chr 3:109,260,526...109,295,588
Ensembl chr 3:109,262,397...109,295,563

G

dual oxidase 2

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of DUOX2 mRNA

NCBI chr 3:109,223,809...109,247,023
Ensembl chr 3:109,226,924...109,245,902

G

dual specificity phosphatase 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of DUSP1 mRNA

NCBI chr10:16,680,478...16,683,275

G

dual specificity phosphatase 11

decreases expression

Gold results in decreased expression of DUSP11 mRNA

NCBI chr 4:118,367,673...118,385,183
Ensembl chr 4:118,368,053...118,385,181

G

deoxyuridine triphosphatase

decreases expression

Gold results in decreased expression of DUT mRNA

NCBI chr 3:112,498,864...112,509,994
Ensembl chr 3:112,498,982...112,510,771

G

DAZ interacting zinc finger protein 3

decreases expression

Gold results in decreased expression of DZIP3 mRNA

NCBI chr11:51,823,235...51,893,353
Ensembl chr11:51,823,231...51,893,353

G

ER degradation enhancing alpha-mannosidase like protein 3

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of EDEM3 mRNA
Gold analog results in decreased expression of EDEM3 mRNA

PMID:28433809 PMID:36057382

NCBI chr13:63,858,282...63,920,538
Ensembl chr13:63,858,716...63,920,523

G

early endosome antigen 1

decreases expression

Gold results in decreased expression of EEA1 mRNA

NCBI chr 7:30,554,686...30,722,186
Ensembl chr 7:30,554,552...30,718,487

G

eukaryotic translation elongation factor 1 delta

decreases expression

Gold analog results in decreased expression of EEF1D protein

NCBI chr 7:107,581,930...107,596,735
Ensembl chr 7:107,581,930...107,608,799

G

eukaryotic translation elongation factor 2

decreases expression

Gold analog results in decreased expression of EEF2 protein

NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183

G

epidermal growth factor

multiple interactions

[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased acetylation of and results in increased stability of EP300 protein]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 mRNA]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of RELA protein]; EP300 protein inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]]

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

multiple interactions

[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase

decreases expression

Gold analog results in decreased expression of EHHADH mRNA

NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188

G

EP300 interacting inhibitor of differentiation 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of EID1 mRNA

NCBI chr 3:112,922,961...112,924,680
Ensembl chr 3:112,922,668...112,924,752

G

eukaryotic translation initiation factor 1A, X-linked

decreases expression

Gold results in decreased expression of EIF1AX mRNA

NCBI chr X:35,498,698...35,513,402
Ensembl chr X:35,498,517...35,513,335

G

eukaryotic translation initiation factor 2 alpha kinase 3

increases phosphorylation

Gold analog results in increased phosphorylation of EIF2AK3 protein

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

eukaryotic translation initiation factor 4A2

decreases expression

Gold results in decreased expression of EIF4A2 mRNA

NCBI chr11:77,764,126...77,770,810
Ensembl chr11:77,764,124...77,770,781

G

eukaryotic translation initiation factor 4E

multiple interactions

[Quercetin analog co-treated with Gold analog] results in decreased expression of EIF4E protein

NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683

G

eukaryotic translation initiation factor 4E binding protein 3

multiple interactions

[Quercetin analog co-treated with Gold analog] results in increased expression of EIF4EBP3 protein

NCBI chr18:28,263,089...28,268,033
Ensembl chr18:28,162,311...28,268,024

G

eukaryotic translation initiation factor 5B

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of EIF5B mRNA
Gold analog results in decreased expression of EIF5B mRNA

PMID:28433809 PMID:36057382

NCBI chr 9:40,222,769...40,277,482
Ensembl chr 9:40,222,898...40,277,482

G

enolase 1

multiple interactions

Gold analog results in decreased expression of and results in increased phosphorylation of ENO1 protein

NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
Ensembl chr 3:160,719,951...160,731,336

G

E1A binding protein p300

multiple interactions

[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased acetylation of and results in increased stability of EP300 protein]; [Polyethyleneimine binds to Gold] which results in decreased expression of EP300 mRNA; EP300 protein inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]

PMID:27634460 PMID:28433809

NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088

G

epithelial mitogen

increases expression

Gold results in increased expression of EPGN mRNA

NCBI chr14:17,076,774...17,084,806
Ensembl chr14:17,076,774...17,084,806

G

Eph receptor A1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of EPHA1 mRNA

NCBI chr 4:71,246,409...71,260,920
Ensembl chr 4:71,246,409...71,260,846

G

epoxide hydrolase 1

increases expression

Gold analog results in increased expression of EPHX1 mRNA

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

ERCC excision repair 2, TFIIH core complex helicase subunit

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of ERCC2 mRNA

NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102

G

ERCC excision repair 6, chromatin remodeling factor

decreases expression

Gold analog results in decreased expression of ERCC6 mRNA

NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587

G

endoplasmic reticulum to nucleus signaling 1

increases phosphorylation

Gold analog results in increased phosphorylation of ERN1 protein

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

G

endoplasmic reticulum to nucleus signaling 2

increases expression

Gold analog results in increased expression of ERN2 mRNA

NCBI chr 1:176,726,454...176,743,289
Ensembl chr 1:176,726,454...176,743,289

G

endoplasmic reticulum oxidoreductase 1 alpha

increases expression

Gold results in increased expression of ERO1A mRNA

NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478

G

establishment of sister chromatid cohesion N-acetyltransferase 2

decreases expression

Gold results in decreased expression of ESCO2 mRNA

NCBI chr15:40,034,566...40,052,295
Ensembl chr15:40,034,568...40,055,306

G

estrogen receptor 1

decreases expression

Gold analog results in decreased expression of ESR1 mRNA

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

ecotropic viral integration site 5

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of EVI5 mRNA

NCBI chr14:1,875,601...2,021,678
Ensembl chr14:1,875,647...2,021,678

G

even-skipped homeobox 1

increases expression

Gold results in increased expression of EVX1 mRNA

NCBI chr 4:81,416,590...81,420,967
Ensembl chr 4:81,416,590...81,420,967

G

FA complementation group L

decreases expression

Gold results in decreased expression of FANCL mRNA

NCBI chr14:100,249,733...100,317,958
Ensembl chr14:100,248,875...100,314,255

G

Fas cell surface death receptor

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of FAS mRNA
Gold analog results in decreased expression of FAS mRNA

PMID:28433809 PMID:36057382

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

fatty acid synthase

decreases expression

Gold analog results in decreased expression of FASN mRNA

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

fibroblast growth factor 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of FGF1 mRNA

NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357

G

fumarate hydratase

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of FH mRNA

NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266

G

FKBP prolyl isomerase 9

increases phosphorylation
decreases expression

Gold analog results in increased phosphorylation of FKBP9 protein
Gold analog results in decreased expression of FKBP9 protein

NCBI chr 4:86,106,256...86,156,723
Ensembl chr 4:86,106,282...86,156,721

G

flavin containing dimethylaniline monoxygenase 5

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of FMO5 mRNA

NCBI chr 2:185,197,184...185,249,699
Ensembl chr 2:185,222,204...185,249,693

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

[Gold co-treated with Silicon Dioxide] results in increased expression of FOS mRNA
Gold results in increased expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

ferritin heavy chain 1

increases expression

Gold results in increased expression of FTH1 mRNA

NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424

G

FYN binding protein 1

increases expression

Gold results in increased expression of FYB1 mRNA

NCBI chr 2:55,621,585...55,781,206
Ensembl chr 2:55,632,698...55,779,629

G

frizzled class receptor 4

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of FZD4 mRNA

NCBI chr 1:143,279,934...143,288,799
Ensembl chr 1:143,280,065...143,285,724

G

G2/M-phase specific E3 ubiquitin protein ligase

decreases expression

Gold results in decreased expression of G2E3 mRNA

NCBI chr 6:68,763,847...68,795,305
Ensembl chr 6:68,764,185...68,793,924

G

polypeptide N-acetylgalactosaminyltransferase 1

decreases expression

Gold results in decreased expression of GALNT1 mRNA

NCBI chr18:15,489,015...15,568,849
Ensembl chr18:15,489,020...15,568,245

G

polypeptide N-acetylgalactosaminyltransferase 5

decreases expression

Gold analog results in decreased expression of GALNT5 mRNA

NCBI chr 3:42,573,622...42,619,881
Ensembl chr 3:42,573,622...42,619,881

G

glucosidase, alpha; neutral C

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of GANC mRNA

NCBI chr 3:107,353,369...107,406,104
Ensembl chr 3:107,353,369...107,405,241

G

glyceraldehyde-3-phosphate dehydrogenase

decreases expression

Gold analog results in decreased expression of GAPDH protein

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

grancalcin

decreases expression

Gold results in decreased expression of GCA mRNA

NCBI chr 3:47,297,320...47,329,913
Ensembl chr 3:47,297,383...47,328,581

G

glutaryl-CoA dehydrogenase

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of GCDH mRNA

NCBI chr19:23,263,215...23,269,689
Ensembl chr19:23,263,264...23,269,681

G

guanine monophosphate synthase

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of GMPS mRNA

NCBI chr 2:148,441,369...148,491,908
Ensembl chr 2:148,435,643...148,485,875

G

G protein subunit gamma 10

decreases expression

Gold results in decreased expression of GNG10 mRNA

NCBI chr 5:73,856,124...73,863,017
Ensembl chr 5:73,856,164...73,863,012
Ensembl chr 5:73,856,164...73,863,012

G

glutamic-oxaloacetic transaminase 2

decreases expression

Gold analog results in decreased expression of GOT2 protein

NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994

G

G protein-coupled receptor 182

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of GPR182 mRNA

NCBI chr 7:63,585,997...63,589,088
Ensembl chr 7:63,578,750...63,589,210

G

glutamic--pyruvic transaminase

multiple interactions
decreases expression

[Gold binds to NKCT1 protein, Naja kaouthia] inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]; [Gold binds to NKCT1 protein, Naja kaouthia] inhibits the reaction [Diethylnitrosamine results in increased expression of GPT protein]
Gold analog results in decreased expression of GPT mRNA
[Polyethyleneimine binds to Gold] which results in decreased expression of GPT mRNA

PMID:27836789 PMID:28433809 PMID:36057382

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 2

increases expression

Gold analog results in increased expression of GPX2 mRNA; Gold results in increased expression of GPX2 mRNA

PMID:25523186 PMID:36057382

NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877

G

glutathione peroxidase 3

increases expression

Gold analog results in increased expression of GPX3 mRNA

NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035

G

gelsolin

decreases expression
increases degradation

Gold analog results in decreased expression of GSN protein
Gold analog results in increased degradation of GSN protein

PMID:24780912 PMID:26551149

NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402

G

glutathione S-transferase mu 4

multiple interactions
increases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of GSTM4 mRNA
Gold analog results in increased expression of GSTM4 mRNA

PMID:28433809 PMID:36057382

NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323

G

3-hydroxyanthranilate 3,4-dioxygenase

increases expression

Gold analog results in increased expression of HAAO mRNA

NCBI chr 6:10,845,235...10,864,863
Ensembl chr 6:10,845,771...10,864,877

G

histone acetyltransferase 1

decreases expression

Gold results in decreased expression of HAT1 mRNA

NCBI chr 3:56,217,344...56,265,021
Ensembl chr 3:56,217,342...56,275,517

G

hepatitis A virus cellular receptor 1

multiple interactions

[Polyethylene Glycols binds to Gold] which results in increased expression of HAVCR1 protein; [Polyethyleneimine binds to Gold] which results in increased expression of HAVCR1 protein; [Thioctic Acid binds to Gold] which results in increased expression of HAVCR1 protein

NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698

G

hydroxycarboxylic acid receptor 2

increases expression

Gold results in increased expression of HCAR2 mRNA

NCBI chr12:32,726,252...32,728,238
Ensembl chr12:32,726,184...32,728,504

G

hexosaminidase subunit beta

multiple interactions

[gold chloride results in increased abundance of Gold] which results in increased export of HEXB protein; [gold tetrachloride, acid results in increased abundance of Gold] which results in increased export of HEXB protein

NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223

G

high mobility group box 2

decreases expression

Gold results in decreased expression of HMGB2 mRNA

NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140
Ensembl chr 1:32,710,658...32,713,140

G

heme oxygenase 1

increases expression

Gold results in increased expression of HMOX1 mRNA

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

homeobox A3

decreases expression

Gold analog results in decreased expression of HOXA3 mRNA

NCBI chr 4:81,269,243...81,313,218
Ensembl chr 4:81,269,243...81,313,218

G

hypoxanthine phosphoribosyltransferase 1

decreases expression

Gold results in decreased expression of HPRT1 mRNA

NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154

G

hemopexin

decreases expression

Gold analog results in decreased expression of HPX mRNA

NCBI chr 1:159,932,819...159,940,327
Ensembl chr 1:159,932,755...159,940,328

G

heat shock factor binding protein 1

decreases expression

Gold results in decreased expression of HSBP1 mRNA

NCBI chr19:47,401,039...47,405,373
Ensembl chr19:47,400,966...47,435,821

G

heat shock transcription factor 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of HSF1 mRNA

NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011

G

heat shock protein 90 alpha family class B member 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of HSP90AB1 mRNA

NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488

G

heat shock protein family A (Hsp70) member 13

decreases expression

Gold results in decreased expression of HSPA13 mRNA

NCBI chr11:14,375,669...14,389,853
Ensembl chr11:14,373,275...14,389,895

G

heat shock protein family A (Hsp70) member 1A

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of HSPA1A mRNA

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 1B

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of HSPA1B mRNA

NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

heat shock protein family A (Hsp70) member 2

decreases expression

Gold analog results in decreased expression of HSPA2 mRNA

NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287

G

heat shock protein family A (Hsp70) member 4

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of HSPA4 mRNA

NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001

G

heat shock protein family A (Hsp70) member 8

increases expression

Gold analog results in increased expression of HSPA8 protein

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

heat shock protein family A (Hsp70) member 9

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of HSPA9 mRNA

NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292

G

heat shock protein family B (small) member 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of HSPB1 mRNA
[Polyethyleneimine binds to Gold] which results in decreased expression of HSPB1 mRNA

PMID:19695318 PMID:28433809

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

heat shock protein family D (Hsp60) member 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of HSPD1 mRNA

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

HIV-1 Tat interactive protein 2

increases expression

Gold results in increased expression of HTATIP2 mRNA

NCBI chr 1:99,473,411...99,488,632
Ensembl chr 1:99,469,245...99,488,629

G

HIV-1 Tat specific factor 1

decreases expression

Gold results in decreased expression of HTATSF1 mRNA

NCBI chr X:134,935,426...134,949,607
Ensembl chr X:134,935,426...134,949,607

G

HtrA serine peptidase 4

decreases expression

Gold analog results in decreased expression of HTRA4 mRNA

NCBI chr16:67,001,605...67,015,074
Ensembl chr16:67,001,605...67,015,074

G

hypoxia up-regulated 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of HYOU1 mRNA

NCBI chr 8:44,706,073...44,718,189
Ensembl chr 8:44,706,263...44,718,186

G

isocitrate dehydrogenase (NADP(+)) 1

multiple interactions

Gold analog results in decreased expression of and results in increased phosphorylation of IDH1 protein

NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708

G

isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of IDH3G mRNA

NCBI chr X:151,515,244...151,524,175
Ensembl chr X:151,515,247...151,524,171

G

interferon gamma receptor 1

increases expression

Gold results in increased expression of IFNGR1 mRNA

NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785

G

insulin-like growth factor 1

multiple interactions

Gold inhibits the reaction [IGF1 protein binds to IGF1R protein]

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor 1 receptor

multiple interactions

Gold inhibits the reaction [IGF1 protein binds to IGF1R protein]; Gold inhibits the reaction [IGF2 protein binds to IGF1R protein]

NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777

G

insulin-like growth factor 2

multiple interactions

Gold inhibits the reaction [IGF2 protein binds to IGF1R protein]

NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018

G

IKAROS family zinc finger 2

decreases expression

Gold results in decreased expression of IKZF2 mRNA

NCBI chr 9:71,046,038...71,191,296
Ensembl chr 9:71,042,440...71,190,867

G

interleukin 10

multiple interactions
increases secretion

[Gold co-treated with Silicon Dioxide] results in increased secretion of IL10 protein
Gold results in increased secretion of IL10 protein

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 alpha

multiple interactions
decreases expression
increases secretion

[Gold co-treated with Silicon Dioxide] results in increased secretion of IL1A protein
Gold analog results in decreased expression of IL1A mRNA
Gold results in increased secretion of IL1A protein

PMID:22155353 PMID:36057382

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions
decreases expression
increases secretion

[Gold co-treated with Polyethylene Glycols] results in increased expression of IL1B mRNA; [Gold co-treated with Silicon Dioxide] results in increased secretion of IL1B protein
Gold analog results in decreased expression of IL1B mRNA
Gold results in increased secretion of IL1B protein

PMID:19695318 PMID:22155353 PMID:36057382

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 4

decreases expression

Gold analog results in decreased expression of IL4 mRNA

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

multiple interactions
increases secretion

[Gold co-treated with Polyethylene Glycols] results in increased expression of IL6 mRNA; [Gold co-treated with Silicon Dioxide] results in increased secretion of IL6 protein
[Polyethylene Glycols binds to Gold] which results in increased expression of IL6 protein; [Polyethyleneimine binds to Gold] which results in increased expression of IL6 protein; [Thioctic Acid binds to Gold] which results in increased expression of IL6 protein
Gold results in increased secretion of IL6 protein

PMID:19695318 PMID:22155353 PMID:28433809

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 6 receptor

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of IL6RA mRNA

NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536

G

inositol monophosphatase 1

decreases expression

Gold results in decreased expression of IMPA1 mRNA

NCBI chr 2:91,462,781...91,484,057
Ensembl chr 2:91,462,799...91,484,313

G

inositol polyphosphate multikinase

decreases expression

Gold results in decreased expression of IPMK mRNA

NCBI chr20:17,216,988...17,251,675
Ensembl chr20:17,218,037...17,251,705

G

IQ motif containing GTPase activating protein 2

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of IQGAP2 mRNA

NCBI chr 2:26,894,836...27,170,270
Ensembl chr 2:26,894,825...27,170,279

G

jagged canonical Notch ligand 1

decreases expression

Gold analog results in decreased expression of JAG1 mRNA

NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209

G

Janus kinase 2

multiple interactions

[Quercetin analog co-treated with Gold analog] results in decreased phosphorylation of JAK2 protein

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]; MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

junction plakoglobin

decreases expression

Gold analog results in decreased expression of JUP protein

NCBI chr10:85,300,438...85,327,378
Ensembl chr10:85,300,440...85,327,057

G

ketohexokinase

increases expression

Gold analog results in increased expression of KHK mRNA

NCBI chr 6:25,445,298...25,455,834
Ensembl chr 6:25,445,300...25,455,717

G

Kin17 DNA and RNA binding protein

decreases expression

Gold results in decreased expression of KIN mRNA

NCBI chr17:68,413,483...68,431,392
Ensembl chr17:68,413,486...68,423,845

G

KIT ligand

decreases expression

Gold results in decreased expression of KITLG mRNA

NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214

G

KRR1, small subunit processome component homolog

decreases expression

Gold results in decreased expression of KRR1 mRNA

NCBI chr 7:47,475,557...47,486,996
Ensembl chr 7:47,475,557...47,486,985

G

kynureninase

increases expression

Gold results in increased expression of KYNU mRNA

NCBI chr 3:27,778,646...27,929,470
Ensembl chr 3:27,778,772...27,929,488

G

laccase domain containing 1

increases expression

Gold results in increased expression of LACC1 mRNA

NCBI chr15:52,390,267...52,407,630
Ensembl chr15:52,395,183...52,407,545

G

lactamase, beta 2

decreases expression

Gold results in decreased expression of LACTB2 mRNA

NCBI chr 5:5,569,080...5,591,843
Ensembl chr 5:5,569,067...5,596,429

G

La ribonucleoprotein 1B

decreases expression

Gold results in decreased expression of LARP1B mRNA

NCBI chr 2:123,936,057...123,969,254
Ensembl chr 2:123,935,983...123,968,896

G

LIF, interleukin 6 family cytokine

multiple interactions
increases secretion

[Gold co-treated with Silicon Dioxide] results in increased secretion of LIF protein
Gold results in increased secretion of LIF protein

NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482

G

DNA ligase 4

multiple interactions

[Polyethyleneimine binds to Gold] which affects the expression of LIG4 mRNA

NCBI chr16:79,518,393...79,526,956
Ensembl chr16:79,518,312...79,527,040

G

LIM domain and actin binding 1

decreases expression

Gold results in decreased expression of LIMA1 mRNA

NCBI chr 7:130,901,717...131,001,512
Ensembl chr 7:130,901,717...131,001,473

G

lectin, mannose-binding, 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of LMAN1 mRNA

NCBI chr18:59,508,996...59,530,873
Ensembl chr18:59,508,996...59,530,851

G

lamin A/C

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of LMNA mRNA

NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423

G

lamin B1

increases degradation

Gold analog results in increased degradation of LMNB1 protein

NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502

G

lysophosphatidylglycerol acyltransferase 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of LPGAT1 mRNA

NCBI chr13:103,294,622...103,365,372
Ensembl chr13:103,294,528...103,362,333

G

LRAT domain containing 1

increases expression

Gold results in increased expression of LRATD1 mRNA

NCBI chr 6:36,916,969...36,922,143
Ensembl chr 6:36,913,469...36,922,319

G

LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated

decreases expression

Gold results in decreased expression of LSM5 mRNA

NCBI chr 4:85,951,073...85,954,289
Ensembl chr 6:104,652,477...104,654,165
Ensembl chr 4:104,652,477...104,654,165

G

LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated

decreases expression

Gold results in decreased expression of LSM6 mRNA

NCBI chr19:29,098,254...29,112,858
Ensembl chr13:42,114,032...42,116,484
Ensembl chr19:42,114,032...42,116,484

G

lanosterol synthase

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of LSS mRNA

NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762

G

mitotic arrest deficient 2 like 1

decreases expression

Gold results in decreased expression of MAD2L1 mRNA

NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470

G

microtubule-associated protein 1B

increases expression

Gold results in increased expression of MAP1B mRNA

NCBI chr 2:30,817,261...30,910,458
Ensembl chr 2:30,817,261...30,910,317

G

mitogen activated protein kinase kinase 1

multiple interactions

MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]]

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

muscleblind-like splicing regulator 2

decreases expression

Gold results in decreased expression of MBNL2 mRNA

NCBI chr15:97,385,278...97,542,924
Ensembl chr15:97,385,244...97,542,937

G

malate dehydrogenase 1B

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of MDH1B mRNA
Gold analog results in decreased expression of MDH1B mRNA

PMID:28433809 PMID:36057382

NCBI chr 9:65,120,370...65,168,008
Ensembl chr 9:65,119,029...65,167,933

G

MDM2 proto-oncogene

decreases expression

Gold analog results in decreased expression of MDM2 mRNA

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

mitochondrial trans-2-enoyl-CoA reductase

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of MECR mRNA

NCBI chr 5:144,029,684...144,056,373
Ensembl chr 5:144,029,731...144,055,863

G

MEFV innate immunity regulator, pyrin

increases expression

Gold results in increased expression of MEFV mRNA

NCBI chr10:11,786,948...11,796,977
Ensembl chr10:11,787,422...11,796,973

G

methionyl aminopeptidase 2

decreases expression

Gold analog results in decreased expression of METAP2 mRNA; Gold results in decreased expression of METAP2 mRNA

PMID:25523186 PMID:36057382

NCBI chr 7:28,412,429...28,440,458
Ensembl chr 7:28,411,608...28,440,434

G

marker of proliferation Ki-67

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in increased expression of MKI67 mRNA
Gold analog results in decreased expression of MKI67 mRNA

PMID:28433809 PMID:36057382

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

membrane magnesium transporter 1

decreases expression

Gold results in decreased expression of MMGT1 mRNA

NCBI chr X:134,408,463...134,420,798
Ensembl chr X:134,408,466...134,420,729

G

matrix metallopeptidase 3

increases expression

Gold results in increased expression of MMP3 mRNA

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

matrix metallopeptidase 9

multiple interactions

[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 mRNA]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]; EP300 protein inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

MNAT1 component of CDK activating kinase

decreases expression

Gold results in decreased expression of MNAT1 mRNA

NCBI chr 6:91,814,703...91,971,945
Ensembl chr 6:91,814,749...91,970,744

G

MOB kinase activator 1B

decreases expression

Gold results in decreased expression of MOB1B mRNA

NCBI chr14:19,333,058...19,365,845
Ensembl chr14:19,332,459...19,365,845

G

MOB family member 4, phocein

decreases expression

Gold results in decreased expression of MOB4 mRNA

NCBI chr 9:56,617,374...56,641,336
Ensembl chr 9:56,617,368...56,641,329

G

MORC family CW-type zinc finger 3

decreases expression

Gold results in decreased expression of MORC3 mRNA

NCBI chr11:33,151,906...33,194,650
Ensembl chr11:33,152,025...33,194,646

G

mitochondrial ribosomal protein L3

decreases expression

Gold results in decreased expression of MRPL3 mRNA

NCBI chr 8:105,670,184...105,693,544
Ensembl chr 8:105,670,184...105,693,544

G

mitochondrial ribosomal protein S6

decreases expression

Gold results in decreased expression of MRPS6 mRNA

NCBI chr11:31,295,358...31,348,483
Ensembl chr11:31,295,614...31,348,484

G

metallothionein 1, pseudogene 3

increases expression

Gold results in increased expression of MT1E mRNA

NCBI chr17:74,786,652...74,787,040
Ensembl chr17:74,786,654...74,787,135

G

metallothionein 2A

increases expression

Gold results in increased expression of MT2A mRNA

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

methylenetetrahydrofolate reductase

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of MTHFR mRNA

NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797

G

myotubularin related protein 6

decreases expression

Gold results in decreased expression of MTMR6 mRNA

NCBI chr15:34,419,931...34,457,863
Ensembl chr15:34,419,903...34,457,861

G

mechanistic target of rapamycin kinase

multiple interactions

[Quercetin analog co-treated with Gold analog] results in decreased phosphorylation of MTOR protein

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

MTSS I-BAR domain containing 1

increases expression

Gold results in increased expression of MTSS1 mRNA

NCBI chr 7:90,488,751...90,628,007
Ensembl chr 7:90,488,754...90,627,968

G

microsomal triglyceride transfer protein

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of MTTP mRNA

NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239

G

MYCL proto-oncogene, bHLH transcription factor

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of MYCL mRNA

NCBI chr 5:135,274,713...135,281,584
Ensembl chr 5:135,274,748...135,281,582

G

myoneurin

decreases expression

Gold results in decreased expression of MYNN mRNA

NCBI chr 2:112,779,654...112,797,188
Ensembl chr 2:112,779,657...112,796,397

G

N-acyl phosphatidylethanolamine phospholipase D

decreases expression

Gold results in decreased expression of NAPEPLD mRNA

NCBI chr 4:13,360,532...13,398,815
Ensembl chr 4:13,361,006...13,398,748

G

neutral cholesterol ester hydrolase 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of NCEH1 mRNA

NCBI chr 2:110,074,985...110,135,592
Ensembl chr 2:110,074,957...110,135,588

G

NFE2 like bZIP transcription factor 2

increases activity
increases expression

Gold results in increased activity of NFE2L2 promoter
Gold analog results in increased expression of NFE2L2 mRNA; Gold analog results in increased expression of NFE2L2 protein

PMID:21643505 PMID:36057382

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

decreases expression

Gold analog results in decreased expression of NFKB1 mRNA

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor delta

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of NFKBID mRNA

NCBI chr 1:85,679,353...85,690,415
Ensembl chr 1:85,680,861...85,690,447

G

NFKB inhibitor zeta

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of NFKBIZ mRNA

NCBI chr11:44,782,676...44,810,722
Ensembl chr11:44,782,676...44,810,723

G

NIPBL, cohesin loading factor

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of NIPBL mRNA

NCBI chr 2:57,399,443...57,586,770
Ensembl chr 2:57,399,445...57,565,899

G

nitric oxide synthase 2

increases expression

Gold results in increased expression of NOS2 protein

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

NPL4 homolog, ubiquitin recognition factor

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of NPLOC4 mRNA

NCBI chr10:105,654,395...105,709,958
Ensembl chr10:105,654,812...105,709,913

G

nucleophosmin 1

decreases expression

Gold results in decreased expression of NPM1 mRNA

NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645
Ensembl chr X:17,739,941...17,751,645

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
increases expression

[Polyethyleneimine binds to Gold] which results in increased expression of NQO1 mRNA
Gold analog results in increased expression of NQO1 mRNA; Gold results in increased expression of NQO1 mRNA

PMID:28433809 PMID:29705079 PMID:36057382

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 0, group B, member 2

decreases expression

Gold analog results in decreased expression of NR0B2 mRNA

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

G

nuclear receptor subfamily 4, group A, member 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of NR4A1 mRNA

NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297

G

neuronal cell adhesion molecule

increases expression

Gold results in increased expression of NRCAM mRNA

NCBI chr 6:61,402,813...61,698,536
Ensembl chr 6:61,329,863...61,702,992

G

nuclear receptor interacting protein 1

increases expression

Gold results in increased expression of NRIP1 mRNA

NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761

G

netrin 4

increases expression

Gold results in increased expression of NTN4 mRNA

NCBI chr 7:28,186,611...28,300,390
Ensembl chr 7:28,186,611...28,300,390

G

nucleobindin 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of NUCB1 mRNA

NCBI chr 1:95,968,325...95,999,183
Ensembl chr 1:95,968,326...96,003,220

G

nudix hydrolase 1

decreases expression

Gold analog results in decreased expression of NUDT1 mRNA

NCBI chr12:14,302,514...14,309,559
Ensembl chr12:14,302,694...14,305,826

G

nudix hydrolase 12

decreases expression

Gold results in decreased expression of NUDT12 mRNA

NCBI chr 9:98,741,627...98,755,039
Ensembl chr 9:98,742,360...98,755,039

G

nudix hydrolase 13

decreases expression

Gold analog results in decreased expression of NUDT13 mRNA

NCBI chr15:4,001,787...4,022,404
Ensembl chr15:4,001,794...4,022,293

G

nucleoporin 210

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of NUP210 mRNA

NCBI chr 4:123,511,558...123,609,874
Ensembl chr 4:123,511,559...123,609,874

G

ORC ubiquitin ligase 1

decreases expression

Gold results in decreased expression of OBI1 mRNA

NCBI chr15:81,269,413...81,308,734
Ensembl chr15:81,269,416...81,308,734

G

odr-4 GPCR localization factor homolog

decreases expression

Gold results in decreased expression of ODR4 mRNA

NCBI chr13:62,369,109...62,424,287
Ensembl chr13:62,394,608...62,424,209

G

oxoglutarate dehydrogenase

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of OGDH mRNA

NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479

G

8-oxoguanine DNA glycosylase

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of OGG1 mRNA

NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766

G

origin recognition complex, subunit 4

decreases expression

Gold results in decreased expression of ORC4 mRNA

NCBI chr 3:33,290,844...33,334,022
Ensembl chr 3:33,294,355...33,333,824

G

OS9, endoplasmic reticulum lectin

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of OS9 mRNA

NCBI chr 7:62,915,498...62,957,591
Ensembl chr 7:62,915,515...62,943,745

G

oxidative stress induced growth inhibitor 1

increases expression

Gold results in increased expression of OSGIN1 mRNA

NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516

G

prolyl 4-hydroxylase subunit beta

decreases expression

Gold analog results in decreased expression of P4HB protein

NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500

G

poly (ADP-ribose) polymerase 1

multiple interactions
decreases expression

Organogold Compounds promotes the reaction [Gold binds to PARP1 protein]
Gold analog results in decreased expression of PARP1 mRNA

PMID:21370912 PMID:36057382

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

poly(rC) binding protein 1

decreases expression

Gold analog results in decreased expression of PCBP1 protein

NCBI chr 4:118,972,698...118,974,705
Ensembl chr 4:118,972,661...118,976,500

G

propionyl-CoA carboxylase subunit alpha

decreases expression

Gold analog results in decreased expression of PCCA mRNA

NCBI chr15:99,627,955...99,969,555
Ensembl chr15:99,627,982...99,968,266

G

polycomb group ring finger 5

decreases expression

Gold results in decreased expression of PCGF5 mRNA

NCBI chr 1:234,063,854...234,180,022
Ensembl chr 1:234,063,892...234,175,315

G

polycomb group ring finger 6

decreases expression

Gold results in decreased expression of PCGF6 mRNA

NCBI chr 1:245,925,354...245,944,964
Ensembl chr 1:245,925,360...245,944,914

G

proliferating cell nuclear antigen

decreases expression

Gold analog results in decreased expression of PCNA mRNA

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

phosphodiesterase 4B

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of PDE4B mRNA

NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696

G

period circadian regulator 3

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of PER3 mRNA

NCBI chr 5:161,460,228...161,495,404
Ensembl chr 5:161,459,533...161,495,607

G

phosphatidylinositol glycan anchor biosynthesis, class A

decreases expression

Gold results in decreased expression of PIGA mRNA

NCBI chr X:30,043,033...30,055,861
Ensembl chr X:30,042,343...30,055,804

G

phosphatidylinositol glycan anchor biosynthesis, class F

decreases expression

Gold results in decreased expression of PIGF mRNA

NCBI chr 6:7,589,584...7,617,719
Ensembl chr 6:7,589,570...7,639,675

G

phosphatidylinositol glycan anchor biosynthesis, class K

decreases expression

Gold results in decreased expression of PIGK mRNA

NCBI chr 2:241,630,021...241,715,493
Ensembl chr 2:241,630,053...241,716,134

G

phosphatidylinositol glycan anchor biosynthesis, class Y

decreases expression

Gold results in decreased expression of PIGY mRNA

NCBI chr 8:20,689,621...20,691,863
Ensembl chr 8:20,689,502...20,692,585

G

phosphoinositide-3-kinase regulatory subunit 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of PIK3R1 mRNA

NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631

G

pyruvate kinase M1/2

decreases expression

Gold analog results in decreased expression of PKM protein

NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599

G

phospholipase A2 group VI

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of PLA2G6 mRNA

NCBI chr 7:110,851,378...110,891,557
Ensembl chr 7:110,851,378...110,891,114

G

pleckstrin homology and FYVE domain containing 2

decreases expression

Gold results in decreased expression of PLEKHF2 mRNA

NCBI chr 5:24,091,077...24,106,758
Ensembl chr 5:24,090,688...24,106,601

G

perilipin 3

increases expression

Gold analog results in increased expression of PLIN3 protein

NCBI chr 9:1,111,178...1,123,057
Ensembl chr 9:1,102,366...1,123,147

G

phorbol-12-myristate-13-acetate-induced protein 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of PMAIP1 mRNA

NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429

G

DNA polymerase kappa

decreases expression

Gold results in decreased expression of POLK mRNA

NCBI chr 2:27,822,228...27,882,331
Ensembl chr 2:27,822,679...27,882,313

G

RNA polymerase II, I and III subunit K

decreases expression

Gold results in decreased expression of POLR2K mRNA

NCBI chr 7:67,347,118...67,359,466
Ensembl chr 7:67,356,113...67,357,668

G

popeye domain cAMP effector 1

increases expression

Gold results in increased expression of POPDC1 mRNA

NCBI chr20:48,819,241...48,860,282
Ensembl chr20:48,822,308...48,857,472

G

popeye domain cAMP effector 3

increases expression

Gold results in increased expression of POPDC3 mRNA

NCBI chr20:48,772,397...48,800,677
Ensembl chr20:48,772,462...48,800,593

G

cytochrome p450 oxidoreductase

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of POR mRNA

NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245

G

protein phosphatase 1 catalytic subunit beta

decreases expression

Gold results in decreased expression of PPP1CB mRNA

NCBI chr 6:23,958,813...23,992,841
Ensembl chr 6:23,960,998...23,992,824

G

protein phosphatase 2 scaffold subunit A alpha

decreases expression

Gold analog results in decreased expression of PPP2R1A protein

NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129

G

protein phosphatase 2 regulatory subunit B', epsilon

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of PPP2R5E mRNA

NCBI chr 6:94,168,846...94,317,872
Ensembl chr 6:94,168,846...94,317,872

G

peroxiredoxin 1

decreases expression
increases expression

Gold analog results in decreased expression of PRDX1 protein
Gold analog results in increased expression of PRDX1 mRNA

PMID:24780912 PMID:36057382

NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856

G

proline-rich coiled-coil 2A

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of PRRC2A mRNA

NCBI chr20:3,658,391...3,674,143
Ensembl chr20:3,658,695...3,674,130

G

phosphoserine aminotransferase 1

decreases expression

Gold analog results in decreased expression of PSAT1 protein

NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682

G

proteasome 26S subunit, non-ATPase 14

decreases expression

Gold results in decreased expression of PSMD14 mRNA

NCBI chr 3:46,254,338...46,347,076
Ensembl chr 3:46,254,330...46,347,076

G

polypyrimidine tract binding protein 2

decreases expression

Gold results in decreased expression of PTBP2 mRNA

NCBI chr 2:207,812,659...207,874,019
Ensembl chr 2:207,812,920...207,873,506

G

prostaglandin reductase 1

increases expression

Gold results in increased expression of PTGR1 mRNA

NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666

G

prostaglandin reductase 2

decreases expression

Gold results in decreased expression of PTGR2 mRNA

NCBI chr 6:103,931,367...103,963,113
Ensembl chr 6:103,931,409...103,963,111

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

[Gold co-treated with Silicon Dioxide] results in increased expression of PTGS2 mRNA
[Polyethyleneimine binds to Gold] which results in decreased expression of PTGS2 mRNA
Gold results in increased expression of PTGS2 mRNA

PMID:22155353 PMID:28433809

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine phosphatase, receptor type, C

increases expression

Gold analog results in increased expression of PTPRC mRNA

NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692

G

6-pyruvoyl-tetrahydropterin synthase

decreases expression

Gold results in decreased expression of PTS mRNA

NCBI chr 8:50,870,838...50,877,869
Ensembl chr 8:50,870,841...50,877,869

G

PVR cell adhesion molecule

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of PVR mRNA

NCBI chr 1:79,561,294...79,576,700
Ensembl chr 1:79,546,879...79,576,715

G

RAB11a, member RAS oncogene family

decreases expression

Gold results in decreased expression of RAB11A mRNA

NCBI chr 8:65,223,698...65,246,461
Ensembl chr 8:65,222,949...65,246,525

G

RAB18, member RAS oncogene family

decreases expression

Gold results in decreased expression of RAB18 mRNA

NCBI chr17:54,944,099...54,976,093
Ensembl chr17:54,943,955...54,976,043

G

Rab geranylgeranyltransferase subunit beta

decreases expression

Gold results in decreased expression of RABGGTB mRNA

NCBI chr 2:242,844,758...242,850,951
Ensembl chr 2:242,844,762...242,851,050

G

RAD51 recombinase

decreases expression

Gold analog results in decreased expression of RAD51 mRNA

NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035

G

RAD51 paralog B

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of RAD51B mRNA

NCBI chr 6:98,096,525...98,640,988
Ensembl chr 6:98,098,868...98,640,979

G

retinoic acid induced 14

increases expression

Gold results in increased expression of RAI14 mRNA

NCBI chr 2:59,546,284...59,682,687
Ensembl chr 2:59,546,284...59,681,971

G

RB1-inducible coiled-coil 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of RB1CC1 mRNA

NCBI chr 5:13,161,648...13,225,560
Ensembl chr 5:13,161,648...13,225,560

G

RNA binding motif protein 12

decreases expression

Gold results in decreased expression of RBM12 mRNA

NCBI chr 3:144,609,661...144,629,911
Ensembl chr 3:144,611,623...144,629,915

G

retinol binding protein 1

increases expression

Gold results in increased expression of RBP1 mRNA

NCBI chr 8:99,025,218...99,046,740
Ensembl chr 8:99,025,206...99,046,743

G

ring finger and CCCH-type domains 1

decreases expression

Gold results in decreased expression of RC3H1 mRNA

NCBI chr13:73,174,075...73,245,762
Ensembl chr13:73,173,946...73,238,839

G

radixin

decreases expression

Gold analog results in decreased expression of RDX mRNA

NCBI chr 8:52,379,494...52,437,673
Ensembl chr 8:52,379,494...52,437,678

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

riboflavin kinase

decreases expression

Gold results in decreased expression of RFK mRNA

NCBI chr 1:214,799,880...214,807,440
Ensembl chr 1:214,799,825...214,807,438
Ensembl chr X:214,799,825...214,807,438

G

ras homolog family member U

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of RHOU mRNA

NCBI chr19:51,641,476...51,651,249
Ensembl chr19:51,641,227...51,650,552

G

ring finger protein 11

decreases expression

Gold results in decreased expression of RNF11 mRNA

NCBI chr 5:124,212,433...124,243,125
Ensembl chr 5:124,212,445...124,234,750

G

ring finger protein 13

decreases expression

Gold results in decreased expression of RNF13 mRNA

NCBI chr 2:141,927,887...142,061,801
Ensembl chr 2:141,927,909...142,061,801

G

ring finger protein 138

decreases expression

Gold results in decreased expression of RNF138 mRNA

NCBI chr18:12,291,557...12,315,931
Ensembl chr18:12,291,590...12,315,930

G

ring finger protein 149

decreases expression

Gold results in decreased expression of RNF149 mRNA

NCBI chr 9:41,826,825...41,854,381
Ensembl chr 9:41,830,233...41,854,279

G

ring finger protein 2

decreases expression

Gold results in decreased expression of RNF2 mRNA

NCBI chr13:63,553,964...63,584,047
Ensembl chr13:63,554,862...63,583,099

G

ring finger protein, transmembrane 1

decreases expression

Gold results in decreased expression of RNFT1 mRNA

NCBI chr10:71,310,052...71,322,507
Ensembl chr10:71,310,104...71,323,778

G

Ro60, Y RNA binding protein

decreases expression

Gold results in decreased expression of RO60 mRNA

NCBI chr13:55,499,514...55,520,504
Ensembl chr13:55,499,534...55,520,504

G

RP2 activator of ARL3 GTPase

decreases expression

Gold results in decreased expression of RP2 mRNA

NCBI chr X:1,872,582...1,916,704
Ensembl chr X:1,873,306...1,916,688

G

ribosomal protein S27-like

decreases expression

Gold results in decreased expression of RPS27L mRNA

NCBI chr 8:67,562,483...67,567,418
Ensembl chr 8:67,562,483...67,567,418
Ensembl chr12:67,562,483...67,567,418
Ensembl chr 2:67,562,483...67,567,418

G

ribosomal protein S6 kinase B1

multiple interactions

[Quercetin analog co-treated with Gold analog] results in decreased expression of RPS6KB1 protein

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

RT1 class II, locus Db1

increases expression

Gold analog results in increased expression of HLA-DRB1 mRNA

NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258

G

reticulon 4

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of RTN4 mRNA

NCBI chr14:103,450,074...103,497,687
Ensembl chr14:103,449,930...103,497,686

G

secretion associated, Ras related GTPase 1B

decreases expression

Gold results in decreased expression of SAR1B mRNA

NCBI chr10:36,024,415...36,054,069
Ensembl chr10:36,024,382...36,054,066

G

SAP domain containing ribonucleoprotein

decreases expression

Gold results in decreased expression of SARNP mRNA

NCBI chr 7:1,251,096...1,305,335
Ensembl chr 7:1,251,098...1,305,332

G

short coiled-coil protein

decreases expression

Gold results in decreased expression of SCOC mRNA

NCBI chr19:24,659,651...24,689,237
Ensembl chr19:24,659,651...24,693,217

G

sterol carrier protein 2

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of SCP2 mRNA

NCBI chr 5:122,806,949...122,881,259
Ensembl chr 5:122,776,549...122,881,287

G

Sec23 homolog A, COPII coat complex component

decreases expression

Gold results in decreased expression of SEC23A mRNA

NCBI chr 6:76,658,793...76,706,125
Ensembl chr 6:76,658,427...76,706,035

G

SEC24 homolog A, COPII coat complex component

decreases expression

Gold results in decreased expression of SEC24A mRNA

NCBI chr10:35,946,901...36,024,353
Ensembl chr10:35,947,031...36,024,353

G

SEL1L family member 3

increases expression

Gold results in increased expression of SEL1L3 mRNA

NCBI chr14:57,775,515...57,882,076
Ensembl chr14:57,775,501...57,882,644

G

selenoprotein T

decreases expression

Gold results in decreased expression of SELENOT mRNA

NCBI chr 2:142,804,387...142,821,438
Ensembl chr 2:142,804,405...142,821,427

G

septin 8

decreases expression

Gold analog results in decreased expression of SEPTIN8 protein

NCBI chr10:37,684,649...37,713,704
Ensembl chr10:37,684,639...37,713,174

G

stress-associated endoplasmic reticulum protein 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of SERP1 mRNA

NCBI chr 2:142,757,254...142,761,243
Ensembl chr 2:142,757,270...142,761,116

G

serpin family E member 1

increases expression

Gold results in increased expression of SERPINE1 mRNA

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

serpin family H member 1

decreases expression

Gold analog results in decreased expression of SERPINH1 protein

NCBI chr 1:153,643,500...153,650,853
Ensembl chr 1:153,643,510...153,650,801

G

SH3 domain-containing kinase-binding protein 1

increases expression

Gold results in increased expression of SH3KBP1 mRNA

NCBI chr X:34,877,862...35,223,013
Ensembl chr X:34,877,866...35,222,747

G

solute carrier family 25 member 24

decreases expression

Gold analog results in decreased expression of SLC25A24 protein

NCBI chr 2:196,761,076...196,799,236
Ensembl chr 2:196,761,274...196,799,231

G

SRA stem-loop interacting RNA binding protein

decreases expression

Gold results in decreased expression of SLIRP mRNA

NCBI chr 6:107,088,760...107,097,791
Ensembl chr 6:107,088,403...107,097,791

G

SNF2 related chromatin remodeling ATPase with DExD box 1

decreases expression

Gold results in decreased expression of SMARCAD1 mRNA

NCBI chr 4:94,311,441...94,379,184
Ensembl chr 4:94,311,489...94,372,563

G

structural maintenance of chromosomes 4

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of SMC4 mRNA

NCBI chr 2:153,240,243...153,268,722
Ensembl chr 2:153,240,283...153,271,571

G

structural maintenance of chromosomes 6

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of SMC6 mRNA

NCBI chr 6:33,978,730...34,033,201
Ensembl chr 6:33,978,716...34,031,746

G

small nuclear ribonucleoprotein polypeptide B2

decreases expression

Gold results in decreased expression of SNRPB2 mRNA

NCBI chr 3:130,399,239...130,408,821
Ensembl chr 3:130,399,248...130,408,812

G

sorting nexin 6

decreases expression

Gold results in decreased expression of SNX6 mRNA

NCBI chr 6:72,230,950...72,274,157
Ensembl chr 6:72,229,870...72,315,911

G

superoxide dismutase 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of SOD1 mRNA

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

SP100 nuclear antigen

decreases expression

Gold results in decreased expression of SP100 mRNA

NCBI chr 9:86,310,990...86,377,036
Ensembl chr 9:86,311,032...86,377,034

G

Sp3 transcription factor

decreases expression

Gold results in decreased expression of SP3 mRNA

NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342

G

spastin

decreases expression

Gold results in decreased expression of SPAST mRNA

NCBI chr 6:21,055,349...21,106,586
Ensembl chr 6:21,055,349...21,107,954

G

spermatogenesis associated 2

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of SPATA2 mRNA

NCBI chr 3:156,202,962...156,213,283
Ensembl chr 3:156,202,967...156,211,705

G

sterol regulatory element binding transcription factor 1

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of SREBF1 mRNA
Gold analog results in decreased expression of SREBF1 mRNA

PMID:28433809 PMID:36057382

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

SREK1-interacting protein 1

decreases expression

Gold results in decreased expression of SREK1IP1 mRNA

NCBI chr 2:35,975,978...35,999,636
Ensembl chr 2:35,975,989...35,999,636
Ensembl chr 7:35,975,989...35,999,636

G

signal recognition particle 9

decreases expression

Gold results in decreased expression of SRP9 mRNA

NCBI chr13:93,832,580...93,840,720
Ensembl chr13:93,832,580...93,840,720

G

serine and arginine rich splicing factor 10

decreases expression

Gold results in decreased expression of SRSF10 mRNA

NCBI chr 5:148,088,759...148,102,964
Ensembl chr 5:148,088,823...148,101,768

G

serine and arginine rich splicing factor 3

decreases expression

Gold results in decreased expression of SRSF3 mRNA

NCBI chr20:7,091,928...7,101,860
Ensembl chr20:7,091,910...7,101,078

G

serine and arginine rich splicing factor 7

decreases expression

Gold results in decreased expression of SRSF7 mRNA

NCBI chr 6:14,811,775...14,818,968
Ensembl chr 6:14,811,808...14,818,965

G

signal transducer and activator of transcription 1

multiple interactions
increases expression

[Gold co-treated with Silicon Dioxide] results in increased expression of STAT1 mRNA
Gold results in increased expression of STAT1 mRNA

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

signal transducer and activator of transcription 3

increases expression
multiple interactions

Gold results in increased expression of STAT3 mRNA
[Gold co-treated with Silicon Dioxide] results in increased expression of STAT3 mRNA

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

staufen double-stranded RNA binding protein 2

decreases expression

Gold results in decreased expression of STAU2 mRNA

NCBI chr 5:2,840,741...3,084,935
Ensembl chr 5:2,840,765...3,084,929

G

starch binding domain 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of STBD1 mRNA

NCBI chr14:15,470,452...15,473,857
Ensembl chr14:15,469,582...15,477,443

G

STEAP family member 1

decreases expression

Gold results in decreased expression of STEAP1 mRNA

NCBI chr 4:28,276,972...28,287,484
Ensembl chr 4:28,276,909...28,287,479

G

serine/threonine kinase 26

decreases expression

Gold results in decreased expression of STK26 mRNA

NCBI chr X:130,325,064...130,375,674
Ensembl chr X:130,310,885...130,374,291

G

succinate-CoA ligase ADP-forming subunit beta

decreases expression

Gold analog results in decreased expression of SUCLA2 mRNA; Gold results in decreased expression of SUCLA2 mRNA

PMID:25523186 PMID:36057382

NCBI chr15:48,752,356...48,805,495
Ensembl chr15:48,752,312...48,805,138

G

synaptotagmin 1

decreases expression

Gold analog results in decreased expression of SYT1 mRNA

NCBI chr 7:43,813,204...44,358,020
Ensembl chr 7:43,815,785...44,357,803

G

synoviolin 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of SYVN1 mRNA

NCBI chr 1:203,339,235...203,346,137
Ensembl chr 1:203,339,619...203,346,152

G

tumor-associated calcium signal transducer 2

increases expression

Gold results in increased expression of TACSTD2 mRNA

NCBI chr 4:96,707,950...96,709,650
Ensembl chr 4:96,707,951...96,709,650

G

transcriptional adaptor 1

decreases expression

Gold results in decreased expression of TADA1 mRNA

NCBI chr13:78,632,908...78,646,863
Ensembl chr13:78,632,866...78,647,504

G

TATA-box binding protein associated factor 9b

decreases expression

Gold results in decreased expression of TAF9B mRNA

NCBI chr X:71,289,290...71,300,142
Ensembl chr X:71,289,290...71,300,604

G

transgelin

decreases expression

Gold analog results in decreased expression of TAGLN mRNA

NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668

G

TBL1X/Y related 1

decreases expression

Gold results in decreased expression of TBL1XR1 mRNA

NCBI chr 2:104,788,950...104,929,055
Ensembl chr 2:104,801,721...104,929,055

G

transcription elongation factor A1

decreases expression

Gold results in decreased expression of TCEA1 mRNA

NCBI chr 5:14,631,454...14,668,769
Ensembl chr 5:14,631,454...14,668,745
Ensembl chr15:14,631,454...14,668,745

G

tryptophan 2,3-dioxygenase

decreases expression

Gold results in decreased expression of TDO2 mRNA

NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511

G

testis expressed 30

decreases expression

Gold results in decreased expression of TEX30 mRNA

NCBI chr 9:46,243,416...46,252,273
Ensembl chr 9:46,242,748...46,252,249

G

transcription factor EC

decreases expression

Gold results in decreased expression of TFEC mRNA

NCBI chr 4:45,106,129...45,180,236
Ensembl chr 4:45,107,641...45,180,236

G

tissue factor pathway inhibitor 2

increases expression

Gold results in increased expression of TFPI2 mRNA

NCBI chr 4:31,981,786...31,986,707
Ensembl chr 4:31,982,178...31,986,600

G

transforming growth factor, beta 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of TGFB1 mRNA

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

THAP domain containing 1

decreases expression

Gold results in decreased expression of THAP1 mRNA

NCBI chr16:65,905,348...65,909,942
Ensembl chr16:65,904,230...65,909,942

G

TIA1 cytotoxic granule-associated RNA binding protein

decreases expression

Gold results in decreased expression of TIA1 mRNA

NCBI chr 4:118,852,765...118,883,252
Ensembl chr 4:118,852,837...118,880,586

G

transketolase

decreases expression

Gold analog results in decreased expression of TKT protein

NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698

G

tousled-like kinase 1

increases expression

Gold results in increased expression of TLK1 mRNA

NCBI chr 3:55,520,559...55,627,580
Ensembl chr 3:55,503,358...55,691,968

G

toll-like receptor 2

increases expression
multiple interactions

Gold results in increased expression of TLR2 mRNA
Gold promotes the reaction [SAA1 protein binds to TLR2 protein]

NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630

G

transmembrane 4 L six family member 1

increases expression

Gold results in increased expression of TM4SF1 mRNA

NCBI chr 2:141,456,950...141,466,146
Ensembl chr 2:141,453,310...141,466,146

G

transmembrane p24 trafficking protein 10

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of TMED10 mRNA

NCBI chr 6:104,991,843...105,026,705
Ensembl chr 6:104,991,838...105,026,753

G

tumor necrosis factor

increases secretion
multiple interactions

Gold results in increased secretion of TNF protein
[Gold co-treated with Silicon Dioxide] results in increased secretion of TNF protein

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 3

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of TNFAIP3 mRNA

NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282

G

TNF alpha induced protein 8 like 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of TNFAIP8L1 mRNA

NCBI chr 9:988,587...999,342
Ensembl chr 9:988,594...1,002,254

G

TNF receptor superfamily member 10b

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of TNFRSF10A mRNA

NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467

G

TNF receptor superfamily member 1A

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of TNFRSF1A mRNA

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

TNF superfamily member 10

decreases expression

Gold analog results in decreased expression of TNFSF10 mRNA

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

G

tumor protein p53

increases expression

Gold analog results in increased expression of TRP53 mRNA

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tumor protein, translationally-controlled 1

decreases expression

Gold analog results in decreased expression of TPT1 protein

NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625

G

tripartite motif-containing 23

decreases expression

Gold results in decreased expression of TRIM23 mRNA

NCBI chr 2:35,302,405...35,335,746
Ensembl chr 2:35,302,409...35,335,743

G

tRNA methyltransferase 13 homolog

decreases expression

Gold results in decreased expression of TRMT13 mRNA

NCBI chr 2:204,533,630...204,547,711
Ensembl chr 2:204,533,632...204,546,843

G

TruB pseudouridine synthase family member 1

decreases expression

Gold results in decreased expression of TRUB1 mRNA

NCBI chr 1:256,513,418...256,554,549
Ensembl chr 1:256,515,562...256,552,814

G

tubulin, alpha 1A

decreases expression

Gold analog results in decreased expression of TUBA1A protein

NCBI chr 7:130,113,214...130,116,880
Ensembl chr 7:130,081,032...130,196,186

G

tubulin, beta 5 class I

decreases expression

Gold analog results in decreased expression of TUBB5 protein

NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940

G

Tu translation elongation factor, mitochondrial

multiple interactions

Gold analog results in decreased expression of and results in increased phosphorylation of TUFM protein

NCBI chr 1:181,073,788...181,077,395
Ensembl chr 1:181,073,788...181,077,395

G

thioredoxin domain containing 5

multiple interactions

Gold analog results in decreased expression of and results in increased phosphorylation of TXNDC5 protein

NCBI chr17:26,289,880...26,318,025
Ensembl chr17:26,289,880...26,318,025

G

thioredoxin interacting protein

decreases expression

Gold analog results in decreased expression of TXNIP mRNA

NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886

G

thioredoxin reductase 1

decreases activity
increases expression

Gold results in decreased activity of TXNRD1 protein
Gold results in increased expression of TXNRD1 mRNA

PMID:16510263 PMID:20851179 PMID:29705079

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

G

thioredoxin reductase 2

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of TXNRD2 mRNA

NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156

G

UDP-N-acetylglucosamine pyrophosphorylase 1 like 1

decreases expression

Gold analog results in decreased expression of UAP1L1 protein

NCBI chr 3:8,172,335...8,180,505
Ensembl chr 3:8,173,216...8,180,443

G

ubiquitin-like modifier activating enzyme 2

decreases expression

Gold results in decreased expression of UBA2 mRNA

NCBI chr 1:86,775,239...86,802,685
Ensembl chr 1:86,775,244...86,802,682

G

ubiquitin-conjugating enzyme E2G 2

decreases expression

Gold analog results in decreased expression of UBE2G2 mRNA

NCBI chr20:10,983,734...11,005,468
Ensembl chr20:10,983,742...11,005,447

G

ubiquitin-conjugating enzyme E2H

increases expression

Gold results in increased expression of UBE2H mRNA

NCBI chr 4:58,834,674...58,930,156
Ensembl chr 4:58,834,674...58,930,156

G

ubiquitin-conjugating enzyme E2N

decreases expression

Gold results in decreased expression of UBE2N mRNA

NCBI chr 7:30,154,330...30,184,373
Ensembl chr 7:30,154,616...30,184,355

G

ubiquitin-conjugating enzyme E2W

decreases expression

Gold results in decreased expression of UBE2W mRNA

NCBI chr 5:2,690,742...2,754,491
Ensembl chr 5:2,690,763...2,814,965

G

uncoupling protein 2

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of UCP2 mRNA

NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611

G

UDP glucuronosyltransferase family 1 member A1

decreases expression

Gold analog results in decreased expression of UGT1A1 mRNA

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 2 member A1

decreases expression

Gold analog results in decreased expression of UGT2A1 mRNA

NCBI chr14:20,521,018...20,545,934
Ensembl chr14:20,517,951...20,545,531

G

ubiquitin interaction motif containing 1

increases expression
decreases expression

Gold results in increased expression of UIMC1 mRNA
Gold results in decreased expression of UIMC1 mRNA

NCBI chr17:9,523,793...9,592,810
Ensembl chr17:9,527,794...9,592,799

G

uridine phosphorylase 2

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of UPP2 mRNA

NCBI chr 3:43,273,048...43,317,417
Ensembl chr 3:43,273,048...43,317,417

G

ubiquitin specific peptidase 1

decreases expression

Gold results in decreased expression of USP1 mRNA

NCBI chr 5:113,587,564...113,598,934
Ensembl chr 5:113,587,564...113,598,932

G

ubiquitin specific peptidase 15

decreases expression

Gold results in decreased expression of USP15 mRNA

NCBI chr 7:58,756,714...58,848,778
Ensembl chr 7:58,756,872...58,848,721

G

ubiquitin specific peptidase 16

decreases expression

Gold results in decreased expression of USP16 mRNA

NCBI chr11:26,681,359...26,711,313
Ensembl chr11:26,681,414...26,710,539

G

ubiquitin specific peptidase 33

decreases expression

Gold results in decreased expression of USP33 mRNA

NCBI chr 2:241,283,209...241,328,479
Ensembl chr 2:241,292,985...241,328,479

G

ubiquitin specific peptidase 5

decreases expression

Gold analog results in decreased expression of USP5 protein

NCBI chr 4:157,619,663...157,634,681
Ensembl chr 4:157,619,643...157,634,711

G

vinculin

decreases expression

Gold analog results in decreased expression of VCL protein

NCBI chr15:3,265,776...3,355,586
Ensembl chr15:3,265,815...3,355,606

G

vimentin

increases degradation

Gold analog results in increased degradation of VIM protein

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

WW domain binding protein 4

decreases expression

Gold results in decreased expression of WBP4 mRNA

NCBI chr15:54,862,700...54,890,668
Ensembl chr15:54,862,843...54,890,647

G

WEE1 G2 checkpoint kinase

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of WEE1 mRNA

NCBI chr 1:164,173,681...164,197,688
Ensembl chr 1:164,174,779...164,197,688

G

XPA, DNA damage recognition and repair factor

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of XPA mRNA

NCBI chr 5:60,431,673...60,475,726
Ensembl chr 5:60,431,673...60,475,726

G

XPC complex subunit, DNA damage recognition and repair factor

decreases expression

Gold analog results in decreased expression of XPC mRNA

NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010

G

X-ray repair cross complementing 5

decreases expression

Gold analog results in decreased expression of XRCC5 mRNA

NCBI chr 9:73,955,216...74,044,020
Ensembl chr 9:73,955,216...74,044,018

G

YOD1 deubiquitinase

decreases expression

Gold results in decreased expression of YOD1 mRNA

NCBI chr13:42,175,047...42,181,661
Ensembl chr13:42,174,820...42,177,205

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of YWHAG mRNA

NCBI chr12:20,744,500...20,772,828
Ensembl chr12:20,744,535...20,772,827

G

zinc finger and BTB domain containing 21

decreases expression

Gold results in decreased expression of ZBTB21 mRNA

NCBI chr11:37,312,337...37,327,040
Ensembl chr11:37,312,378...37,326,996

G

zinc finger and BTB domain containing 41

decreases expression

Gold results in decreased expression of ZBTB41 mRNA

NCBI chr13:51,042,948...51,065,768
Ensembl chr13:51,042,948...51,065,768

G

zinc finger CCCH-type containing 15

decreases expression

Gold results in decreased expression of ZC3H15 mRNA

NCBI chr 3:68,744,591...68,764,335
Ensembl chr 3:68,744,604...68,764,333

G

zinc finger CCHC-type containing 10

decreases expression

Gold results in decreased expression of ZCCHC10 mRNA

NCBI chr10:37,470,628...37,481,027

G

zinc finger CCHC-type containing 9

decreases expression

Gold results in decreased expression of ZCCHC9 mRNA

NCBI chr 2:23,038,156...23,048,249
Ensembl chr 2:23,038,317...23,048,217

G

zinc finger CCHC-type and RNA binding motif containing 1

decreases expression

Gold results in decreased expression of ZCRB1 mRNA

NCBI chr 7:124,525,227...124,538,564
Ensembl chr 7:124,524,870...124,571,261

G

zinc finger DHHC-type palmitoyltransferase 17

decreases expression

Gold results in decreased expression of ZDHHC17 mRNA

NCBI chr 7:46,369,963...46,433,691
Ensembl chr 7:46,369,988...46,433,764

G

zinc finger DHHC-type palmitoyltransferase 20

decreases expression

Gold results in decreased expression of ZDHHC20 mRNA

NCBI chr15:31,980,057...32,039,006
Ensembl chr15:31,983,155...32,038,989

G

zinc finger AN1-type containing 1

decreases expression

Gold results in decreased expression of ZFAND1 mRNA

NCBI chr 2:91,444,497...91,457,540
Ensembl chr 2:91,444,508...91,453,246

G

zinc finger AN1-type containing 6

decreases expression

Gold results in decreased expression of ZFAND6 mRNA

NCBI chr 1:138,581,002...138,652,052
Ensembl chr 1:138,581,002...138,651,939

G

zinc finger protein 277

decreases expression

Gold results in decreased expression of ZNF277 mRNA

NCBI chr 6:57,383,454...57,512,785
Ensembl chr 6:57,383,951...57,512,765

G

zinc finger protein 422

decreases expression

Gold results in decreased expression of ZNF22 mRNA

NCBI chr 4:149,885,805...149,893,287
Ensembl chr 4:149,885,600...149,893,257

G

zinc finger FYVE-type containing 16

decreases expression

Gold results in decreased expression of ZFYVE16 mRNA

NCBI chr 2:23,713,018...23,757,576
Ensembl chr 2:23,713,766...23,756,990

G

zinc metallopeptidase STE24

decreases expression

Gold results in decreased expression of ZMPSTE24 mRNA

NCBI chr 5:134,627,218...134,660,360
Ensembl chr 5:134,627,229...134,660,110

G

zinc finger RANBP2-type containing 2

decreases expression

Gold results in decreased expression of ZRANB2 mRNA

NCBI chr 2:246,573,110...246,586,942
Ensembl chr 2:246,573,166...246,586,942

G

zinc finger containing ubiquitin peptidase 1

decreases expression

Gold results in decreased expression of ZUP1 mRNA

NCBI chr20:30,785,226...30,815,377
Ensembl chr20:30,785,227...30,815,306

auranofin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

Auranofin promotes the reaction [arsenite results in increased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

albumin

affects binding

Auranofin analog binds to ALB protein

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

BCL2-antagonist/killer 1

multiple interactions
increases response to substance

[BAX co-treated with BAK1] results in increased susceptibility to Auranofin; BAK1 mutant form inhibits the reaction [Auranofin results in increased activity of CASP3 protein]
BAK1 results in increased susceptibility to Auranofin

PMID:18789312 PMID:21172426

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases response to substance

[BAX co-treated with BAK1] results in increased susceptibility to Auranofin; BAX mutant form inhibits the reaction [Auranofin results in increased activity of CASP3 protein]
BAX results in increased susceptibility to Auranofin

PMID:18789312 PMID:21172426

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

BCL2 protein inhibits the reaction [Auranofin results in increased activity of CASP3 protein]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 3

multiple interactions
increases activity

Auranofin promotes the reaction [TNF protein results in increased activity of CASP3 protein]; Auranofin results in decreased expression of and results in increased cleavage of CASP3 protein; BCL2 protein inhibits the reaction [Auranofin results in increased activity of CASP3 protein]
BAK1 mutant form inhibits the reaction [Auranofin results in increased activity of CASP3 protein]; BAX mutant form inhibits the reaction [Auranofin results in increased activity of CASP3 protein]

PMID:15159275 PMID:15191400 PMID:18789312 PMID:20542334 PMID:21699084

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

multiple interactions

Auranofin results in decreased expression of and results in increased cleavage of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions

Auranofin results in decreased expression of and results in increased cleavage of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

cyclin-dependent kinase inhibitor 1A

increases expression

Auranofin results in increased expression of CDKN1A protein

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

CCAAT/enhancer binding protein epsilon

multiple interactions

[Auranofin co-treated with Tretinoin] results in increased expression of CEBPE protein

NCBI chr15:28,169,711...28,171,471
Ensembl chr15:28,169,704...28,171,814

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions

Auranofin inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased activity of CHUK protein]; Auranofin inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein]
Auranofin inhibits the reaction [TNF protein results in increased activity of CHUK protein]

NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065

G

iodothyronine deiodinase 1

decreases activity

Auranofin results in decreased activity of DIO1 protein

NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970

G

epidermal growth factor

multiple interactions

Auranofin promotes the reaction [arsenite results in increased expression of and results in increased secretion of EGF protein]

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

glutathione peroxidase 1

multiple interactions
increases expression

[Peptidoglycan co-treated with Lipopolysaccharides] promotes the reaction [Auranofin results in increased expression of GPX1 protein]; Auranofin promotes the reaction [[Lipopolysaccharides co-treated with Peptidoglycan] results in increased expression of GPX1 protein]

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione-disulfide reductase

multiple interactions

Auranofin promotes the reaction [arsenite results in increased activity of GSR protein]

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

heme oxygenase 1

increases expression

Auranofin results in increased expression of HMOX1 mRNA
Auranofin results in increased expression of HMOX1 mRNA; Auranofin results in increased expression of HMOX1 protein

PMID:22008538 PMID:23942037

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

interleukin 1 beta

multiple interactions

Auranofin inhibits the reaction [IL1B protein affects the localization of RELA protein]; Auranofin inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; Auranofin inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

[Auranofin co-treated with IL6 protein] results in decreased phosphorylation of IL6ST protein; [Auranofin co-treated with IL6 protein] results in decreased phosphorylation of JAK2 protein; [Auranofin co-treated with IL6 protein] results in decreased phosphorylation of STAT3 protein

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 6 cytokine family signal transducer

multiple interactions

[Auranofin co-treated with IL6 protein] results in decreased phosphorylation of IL6ST protein

NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936

G

interleukin-1 receptor-associated kinase 1

multiple interactions

Auranofin inhibits the reaction [lipopolysaccharide A results in increased degradation of IRAK1 protein]

NCBI chr X:151,768,621...151,778,521
Ensembl chr X:151,768,777...151,778,521

G

interferon regulatory factor 3

multiple interactions

Auranofin inhibits the reaction [lipopolysaccharide A results in increased activity of IRF3 protein]; Auranofin inhibits the reaction [lipopolysaccharide A results in increased phosphorylation of IRF3 protein]; Auranofin inhibits the reaction [TBK1 protein results in increased activity of IRF3 protein]; Auranofin inhibits the reaction [TICAM1 protein results in increased activity of IRF3 protein]

NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935

G

integrin subunit alpha M

multiple interactions

[Auranofin co-treated with Tretinoin] results in increased expression of ITGAM protein

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

G

Janus kinase 2

multiple interactions

[Auranofin co-treated with IL6 protein] results in decreased phosphorylation of JAK2 protein

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

mitogen activated protein kinase 1

multiple interactions

Auranofin promotes the reaction [arsenite results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

Auranofin promotes the reaction [arsenite results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

Auranofin promotes the reaction [arsenite results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

MCL1 apoptosis regulator, BCL2 family member

multiple interactions
decreases expression

[Auranofin co-treated with SN50 peptide] results in decreased expression of MCL1 protein
Auranofin results in decreased expression of MCL1 protein

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

NFE2 like bZIP transcription factor 2

multiple interactions

Auranofin promotes the reaction [arsenite results in increased expression of NFE2L2 protein]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFKB inhibitor alpha

multiple interactions

Auranofin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

NFKB inhibitor beta

multiple interactions

Auranofin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIB protein]

NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862

G

poly (ADP-ribose) polymerase 1

decreases activity
increases cleavage

Auranofin results in decreased activity of PARP1 protein
Auranofin results in increased cleavage of PARP1 protein

PMID:15159275 PMID:21370912

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

peptidylprolyl isomerase F

increases oxidation
multiple interactions

Auranofin results in increased oxidation of PPIF protein
Auranofin inhibits the reaction [[NADP co-treated with TXNRD1 protein] results in increased activity of PPIF protein]; Cyclosporine promotes the reaction [Auranofin results in increased oxidation of PPIF protein]

NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913

G

peroxiredoxin 3

increases oxidation
multiple interactions

Auranofin results in increased oxidation of PRDX3 protein
Cyclosporine promotes the reaction [Auranofin results in increased oxidation of PRDX3 protein]
Auranofin promotes the reaction [[Lipopolysaccharides co-treated with Peptidoglycan] results in increased expression of PRDX3 protein]

PMID:18789312 PMID:21355852 PMID:26975474

NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111

G

prostaglandin-endoperoxide synthase 2

multiple interactions

[lipopolysaccharide A co-treated with Auranofin] results in decreased expression of PTGS2 protein
Auranofin inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; Auranofin inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]

PMID:10594346 PMID:17034761

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RB transcriptional corepressor 1

decreases phosphorylation

Auranofin results in decreased phosphorylation of RB1 protein

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RNA binding motif, single stranded interacting protein 3

affects response to substance

RBMS3 protein affects the susceptibility to Auranofin

NCBI chr 8:116,305,227...117,625,730
Ensembl chr 8:116,309,882...117,625,423

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Auranofin inhibits the reaction [IL1B protein affects the localization of RELA protein]; Auranofin promotes the reaction [arsenite results in increased phosphorylation of RELA protein]

PMID:10594346 PMID:36343453

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

RT1 class II, locus Ba

increases response to substance

HLA-DQA1 gene polymorphism results in increased susceptibility to Auranofin

NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744

G

RT1 class II, locus Db1

increases response to substance

HLA-DRB1 gene polymorphism results in increased susceptibility to Auranofin

NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258

G

solute carrier family 22 member 2

multiple interactions

Auranofin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

signal transducer and activator of transcription 3

decreases expression
multiple interactions

Auranofin results in decreased expression of STAT3 protein modified form
[Auranofin co-treated with IL6 protein] results in decreased phosphorylation of STAT3 protein

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

TANK-binding kinase 1

multiple interactions

Auranofin inhibits the reaction [TBK1 protein results in increased activity of IRF3 protein]

NCBI chr 7:57,077,830...57,110,868
Ensembl chr 7:57,077,830...57,110,892

G

transforming growth factor alpha

multiple interactions

Auranofin promotes the reaction [arsenite results in increased expression of and results in increased secretion of TGFA protein]

NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894

G

TIR domain containing adaptor molecule 1

multiple interactions

Auranofin inhibits the reaction [TICAM1 protein results in increased activity of IRF3 protein]

NCBI chr 9:1,102,559...1,111,023
Ensembl chr 9:1,102,366...1,123,147

G

toll-like receptor 4

multiple interactions

Auranofin inhibits the reaction [lipopolysaccharide A promotes the reaction [TLR4 protein binds to TLR4 protein]]

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

multiple interactions

Auranofin inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Auranofin promotes the reaction [TNF protein results in increased activity of CASP3 protein]
Auranofin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]

PMID:10820281 PMID:18789312

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

thioredoxin 1

increases oxidation
multiple interactions

Auranofin results in increased oxidation of TXN protein
Auranofin inhibits the reaction [arsenite results in increased expression of TXN protein]

PMID:26975474 PMID:36343453

NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629

G

thioredoxin 2

increases oxidation
multiple interactions

Auranofin results in increased oxidation of TXN2 protein
Cyclosporine promotes the reaction [Auranofin results in increased oxidation of TXN2 protein]

NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359

G

thioredoxin reductase 1

multiple interactions
decreases activity
increases oxidation
increases expression

Auranofin inhibits the reaction [arsenite results in increased expression of and results in increased activity of TXNRD1 protein]; Auranofin inhibits the reaction [Sodium Selenite results in increased activity of TXNRD1 protein]; Auranofin promotes the reaction [Sodium Selenite results in increased expression of TXNRD1 mRNA]; potassium tellurate(IV) promotes the reaction [Auranofin results in increased oxidation of TXNRD1 protein]; Sodium Selenite promotes the reaction [Auranofin results in increased oxidation of TXNRD1 protein]
Auranofin inhibits the reaction [[NADP co-treated with TXNRD1 protein] results in increased activity of PPIF protein]; Auranofin inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]
Auranofin results in decreased activity of TXNRD1 protein
Auranofin results in increased expression of TXNRD1 mRNA

PMID:16510263 PMID:18405881 PMID:18789312 PMID:19486940 PMID:20457604 More...

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

G

thioredoxin reductase 2

multiple interactions
decreases activity

Auranofin inhibits the reaction [Sodium Selenite results in increased activity of TXNRD2 protein]; Auranofin promotes the reaction [Sodium Selenite results in decreased expression of TXNRD2 mRNA]
Auranofin results in decreased activity of TXNRD2 protein

PMID:15458826 PMID:19486940 PMID:21172426 PMID:21355852

NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156

gold nanoparticle

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

tumor necrosis factor

decreases secretion

Topical GNP decreases secretion of Tnf protein in aqeous humor

RGD

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

gold(0)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aminoadipate-semialdehyde synthase

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of AASS mRNA
Gold analog results in decreased expression of AASS mRNA

PMID:28433809 PMID:36057382

NCBI chr 4:51,606,461...51,663,136
Ensembl chr 4:51,606,462...51,663,136

G

ATP binding cassette subfamily B member 1A

increases expression

Gold analog results in increased expression of ABCB1 mRNA

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily B member 4

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of ABCB4 mRNA
Gold analog results in decreased expression of ABCB4 mRNA

PMID:28433809 PMID:36057382

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

ATP binding cassette subfamily C member 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of ABCC1 mRNA

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 2

increases expression

Gold analog results in increased expression of ABCC2 mRNA

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of ABL1 mRNA

NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065

G

acetyl-CoA acyltransferase 1A

decreases expression

Gold analog results in decreased expression of ACAA1 mRNA

NCBI chr 8:119,079,401...119,088,626
Ensembl chr 8:119,079,775...119,088,624

G

acetyl-CoA carboxylase alpha

decreases expression

Gold analog results in decreased expression of ACACA mRNA

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

G

acyl-CoA dehydrogenase family, member 11

decreases expression

Gold analog results in decreased expression of ACAD11 mRNA

NCBI chr 8:104,681,346...104,746,559
Ensembl chr 8:104,681,396...104,746,560

G

acyl-CoA dehydrogenase medium chain

decreases expression

Gold analog results in decreased expression of ACADM mRNA

NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147

G

acyl-CoA dehydrogenase short chain

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of ACADS mRNA

NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898

G

acyl-CoA dehydrogenase, very long chain

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of ACADVL mRNA

NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075

G

aconitase 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of ACO1 mRNA

NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391

G

aconitase 2

decreases expression
multiple interactions

Gold analog results in decreased expression of ACO2 protein
[Polyethyleneimine binds to Gold] which results in increased expression of ACO2 mRNA

PMID:24780912 PMID:28433809

NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261

G

acyl-CoA oxidase 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of ACOX1 mRNA

NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232

G

acyl-CoA oxidase 2

decreases expression

Gold analog results in decreased expression of ACOX2 mRNA

NCBI chr15:16,660,584...16,692,160
Ensembl chr15:16,660,272...16,692,160

G

acid phosphatase 1

decreases expression

Gold results in decreased expression of ACP1 mRNA

NCBI chr 6:47,506,380...47,522,021
Ensembl chr 6:47,506,380...47,522,021

G

activin A receptor type 1C

decreases expression

Gold results in decreased expression of ACVR1C mRNA

NCBI chr 3:42,815,490...42,892,423
Ensembl chr 3:42,822,610...42,892,327

G

ADAM metallopeptidase domain 28

increases expression

Gold results in increased expression of ADAM28 mRNA

NCBI chr15:43,774,463...43,840,726
Ensembl chr15:42,944,467...43,840,672

G

alcohol dehydrogenase 5 (class III), chi polypeptide

decreases expression

Gold results in decreased expression of ADH5 mRNA

NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591

G

adiponectin receptor 2

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of ADIPOR2 mRNA

NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355

G

adrenoceptor alpha 1B

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of ADRA1B mRNA

NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919

G

adrenoceptor beta 2

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of ADRB2 mRNA

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

alpha-2-HS-glycoprotein

decreases expression

Gold analog results in decreased expression of AHSG mRNA

NCBI chr11:78,121,388...78,127,998
Ensembl chr11:78,117,918...78,145,999

G

apoptosis inducing factor, mitochondria associated 1

increases expression

Gold results in increased expression of AIFM1 protein

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

aminoacyl tRNA synthetase complex-interacting multifunctional protein 1

decreases expression

Gold results in decreased expression of AIMP1 mRNA

NCBI chr 2:221,151,907...221,175,458
Ensembl chr 2:221,151,904...221,175,728

G

adenylate kinase 3

decreases expression

Gold results in decreased expression of AK3 mRNA

NCBI chr 1:226,737,472...226,764,647
Ensembl chr 1:226,739,318...226,764,625

G

A-kinase anchoring protein 13

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of AKAP13 mRNA

NCBI chr 1:129,313,183...129,619,647
Ensembl chr 1:129,314,402...129,619,646

G

aldo-keto reductase family 1 member B10

increases expression

Gold results in increased expression of AKR1B10 mRNA

NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852

G

aldo-keto reductase family 1, member C2

increases expression

Gold results in increased expression of AKR1C2 mRNA

NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764

G

aldo-keto reductase family 1, member C3

increases expression

Gold results in increased expression of AKR1C3 mRNA

NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873

G

AKT serine/threonine kinase 1

multiple interactions

[Quercetin analog co-treated with Gold analog] results in decreased phosphorylation of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

albumin

multiple interactions
increases expression

ALB protein results in increased uptake of [Polyethylene Glycols binds to Gold]; ALB protein results in increased uptake of [Polyethyleneimine binds to Gold]; ALB protein results in increased uptake of [Thioctic Acid binds to Gold]
Gold analog results in increased expression of ALB mRNA

PMID:28433809 PMID:36057382

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

annexin A5

increases expression

Gold analog results in increased expression of ANXA5 protein

NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369

G

apoptotic peptidase activating factor 1

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of APAF1 mRNA; [Quercetin analog co-treated with Gold analog] results in increased expression of APAF1 protein
Gold analog results in decreased expression of APAF1 mRNA

PMID:27470402 PMID:28433809 PMID:36057382

NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540

G

apurinic/apyrimidinic endodeoxyribonuclease 1

decreases expression

Gold analog results in decreased expression of APEX1 mRNA

NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785

G

apolipoprotein A4

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of APOA4 mRNA

NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469

G

adenine phosphoribosyl transferase

decreases expression

Gold analog results in decreased expression of APRT protein

NCBI chr19:50,626,201...50,628,491
Ensembl chr19:50,626,202...50,628,431

G

aquaporin 4

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of AQP4 mRNA

NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856

G

ARF like GTPase 1

decreases expression

Gold results in decreased expression of ARL1 mRNA

NCBI chr 7:23,120,004...23,131,173
Ensembl chr 7:23,119,589...23,131,898

G

ARF like GTPase 5B

decreases expression

Gold results in decreased expression of ARL5B mRNA

NCBI chr17:77,955,864...77,979,895
Ensembl chr17:77,955,818...77,979,854

G

arylsulfatase G

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of ARSG mRNA

NCBI chr10:94,412,261...94,551,224
Ensembl chr10:94,447,399...94,542,941

G

N-acylsphingosine amidohydrolase 1

decreases expression

Gold analog results in decreased expression of ASAH1 mRNA

NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233

G

activating transcription factor 1

decreases expression

Gold results in decreased expression of ATF1 mRNA

NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670

G

activating transcription factor 4

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of ATF4 mRNA

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

activating transcription factor 6

increases cleavage

Gold analog results in increased cleavage of ATF6 protein

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase

decreases expression

Gold analog results in decreased expression of ATIC protein

NCBI chr 9:73,164,846...73,184,897
Ensembl chr 9:73,164,846...73,184,889

G

atlastin GTPase 2

decreases expression

Gold results in decreased expression of ATL2 mRNA

NCBI chr 6:15,139,071...15,180,421
Ensembl chr 6:15,139,044...15,180,421

G

ATM serine/threonine kinase

decreases expression

Gold analog results in decreased expression of ATM mRNA

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

ATPase plasma membrane Ca2+ transporting 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of ATP2B1 mRNA

NCBI chr 7:33,735,595...33,845,226
Ensembl chr 7:33,735,871...33,843,295

G

ATP synthase F1 subunit beta

multiple interactions

Gold analog results in increased expression of and results in decreased phosphorylation of ATP5F1B protein

NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273

G

ATPase H+ transporting V1 subunit G2

decreases expression

Gold analog results in decreased expression of ATP6V1G2 mRNA

NCBI chr20:3,587,681...3,591,309
Ensembl chr20:3,587,686...3,590,481

G

ATR serine/threonine kinase

decreases expression

Gold analog results in decreased expression of ATR mRNA

NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136

G

beta-secretase 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of BACE1 mRNA

NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876

G

BCL2-associated agonist of cell death

multiple interactions

[Quercetin analog co-treated with Gold analog] results in increased expression of BAD protein

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BAR/IMD domain containing adaptor protein 2

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of BAIAP2 mRNA

NCBI chr10:105,223,065...105,290,130
Ensembl chr10:105,223,090...105,290,134

G

BCL2-antagonist/killer 1

increases expression

Gold results in increased expression of BAK1 mRNA

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which affects the localization of BAX protein; [Gold analog co-treated with Platinum] results in increased expression of BAX mRNA; [Polyethyleneimine binds to Gold] which results in decreased expression of BAX mRNA; [Quercetin analog co-treated with Gold analog] results in increased expression of BAX protein
[Gold binds to NKCT1 protein, Naja kaouthia] which results in increased expression of BAX protein
Gold results in increased expression of BAX mRNA

PMID:21621595 PMID:22178767 PMID:25846798 PMID:27470402 PMID:27836789 More...

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCAS2, pre-mRNA processing factor

decreases expression

Gold results in decreased expression of BCAS2 mRNA

NCBI chr 2:190,692,503...190,700,386
Ensembl chr 2:190,692,461...190,700,389

G

BCL2, apoptosis regulator

multiple interactions

[Gold analog co-treated with Platinum] results in decreased expression of BCL2 mRNA; [Quercetin analog co-treated with Gold analog] results in decreased expression of BCL2 protein
[Gold binds to NKCT1 protein, Naja kaouthia] which results in decreased expression of BCL2 protein

PMID:25846798 PMID:27470402 PMID:27836789

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of BCL2L1 mRNA

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

Bcl2-like 11

decreases expression

Gold analog results in decreased expression of BCL2L11 mRNA

NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068

G

baculoviral IAP repeat-containing 2

decreases expression

Gold results in decreased expression of BIRC2 mRNA

NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732

G

baculoviral IAP repeat-containing 3

decreases expression

Gold analog results in decreased expression of BIRC3 mRNA; Gold results in decreased expression of BIRC3 mRNA

PMID:25523186 PMID:36057382

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

basic helix-loop-helix ARNT like 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of BMAL1 mRNA

NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231

G

BMI1 proto-oncogene, polycomb ring finger

decreases expression

Gold results in decreased expression of BMI1 mRNA

NCBI chr17:81,332,175...81,341,625
Ensembl chr17:81,332,214...81,388,690

G

BRCA1, DNA repair associated

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of BRCA1 mRNA
Gold analog results in decreased expression of BRCA1 mRNA

PMID:28433809 PMID:36057382

NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304

G

BRCA2, DNA repair associated

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of BRCA2 mRNA
Gold analog results in decreased expression of BRCA2 mRNA

PMID:28433809 PMID:36057382

NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567

G

C1D nuclear receptor corepressor

decreases expression

Gold results in decreased expression of C1D mRNA

NCBI chr14:91,660,951...91,673,177
Ensembl chr14:91,660,989...91,672,852

G

complement C3

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of C3 mRNA

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

G

similar to human chromosome 11 open reading frame 54

decreases expression

Gold results in decreased expression of C11ORF54 mRNA

NCBI chr 8:12,123,839...12,146,412
Ensembl chr 8:12,123,823...12,146,473

G

complement C9

decreases expression

Gold analog results in decreased expression of C9 mRNA

NCBI chr 2:55,573,094...55,621,345
Ensembl chr 2:55,572,992...55,621,338

G

capping actin protein of muscle Z-line subunit alpha 2

decreases expression

Gold results in decreased expression of CAPZA2 mRNA

NCBI chr 4:45,978,142...46,014,032
Ensembl chr 4:45,977,807...46,013,864

G

carbonic anhydrase 13

decreases expression

Gold results in decreased expression of CA13 mRNA

NCBI chr 2:86,928,401...86,959,525
Ensembl chr 2:86,928,383...86,959,525

G

caspase 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of CASP1 mRNA

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

multiple interactions
increases activity
increases cleavage
increases expression

[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which results in increased activity of CASP3 protein; [Gold analog co-treated with Platinum] results in increased activity of CASP3 protein; [Gold analog co-treated with Platinum] results in increased expression of CASP3 mRNA; [Polyethyleneimine binds to Gold] which results in increased expression of CASP3 mRNA; [Quercetin analog co-treated with Gold analog] results in increased cleavage of CASP3 protein; [Quercetin analog co-treated with Gold analog] results in increased expression of and results in increased activity of CASP3 protein; Dexamethasone promotes the reaction [Gold results in increased activity of CASP3 protein]; Etoposide promotes the reaction [Gold results in increased activity of CASP3 protein]
[Gold binds to NKCT1 protein, Naja kaouthia] which results in increased expression of CASP3 protein
Gold analog results in increased cleavage of CASP3 protein
Gold results in increased expression of CASP3 mRNA

PMID:19760634 PMID:21621595 PMID:22178767 PMID:25846798 PMID:26551149 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 4

increases cleavage

Gold analog results in increased cleavage of CASP4 protein

NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092

G

caspase 7

increases cleavage

Gold analog results in increased cleavage of CASP7 protein

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

increases expression
decreases expression

Gold results in increased expression of CASP8 mRNA
Gold analog results in decreased expression of CASP8 mRNA

PMID:22178767 PMID:36057382

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions
increases cleavage

[Gold analog co-treated with Platinum] results in increased activity of CASP9 protein; [Gold analog co-treated with Platinum] results in increased expression of CASP9 mRNA
[Gold binds to NKCT1 protein, Naja kaouthia] which results in increased expression of CASP9 protein
Gold analog results in increased cleavage of CASP9 protein

PMID:25846798 PMID:26551149 PMID:27836789

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

[Gold binds to NKCT1 protein, Naja kaouthia] inhibits the reaction [Diethylnitrosamine results in decreased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

chromobox 3

decreases expression

Gold results in decreased expression of CBX3 mRNA

NCBI chr 4:80,545,450...80,559,284
Ensembl chr 4:80,546,010...80,559,283
Ensembl chr 4:80,546,010...80,559,283

G

C-C motif chemokine ligand 2

multiple interactions
increases secretion

[Gold co-treated with Silicon Dioxide] results in increased secretion of CCL2 protein
Gold results in increased secretion of CCL2 protein

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 5

multiple interactions
increases secretion

[Gold co-treated with Silicon Dioxide] results in increased secretion of CCL5 protein
Gold results in increased secretion of CCL5 protein

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

C-C motif chemokine ligand 7

multiple interactions
increases secretion

[Gold co-treated with Silicon Dioxide] results in increased secretion of CCL7 protein
Gold results in increased secretion of CCL7 protein

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

G

cyclin D1

multiple interactions

[Quercetin analog co-treated with Gold analog] results in decreased expression of CCND1 protein

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

chaperonin containing TCP1 subunit 5

decreases expression

Gold analog results in decreased expression of CCT5 protein

NCBI chr 2:82,591,750...82,602,903
Ensembl chr 2:82,590,630...82,602,930

G

CD19 molecule

increases expression

Gold analog results in increased expression of CD19 mRNA

NCBI chr 1:180,987,286...180,993,920
Ensembl chr 1:180,987,286...180,993,975

G

CD36 molecule

decreases expression

Gold analog results in decreased expression of CD36 mRNA

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

CD40 molecule

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of CD40 mRNA

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

G

CD86 molecule

decreases expression

Gold analog results in decreased expression of CD86 mRNA

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

cytidine deaminase

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of CDA mRNA

NCBI chr 5:150,556,615...150,583,231
Ensembl chr 5:150,556,615...150,583,231

G

cyclin-dependent kinase 1

decreases expression
increases expression

Gold results in decreased expression of CDK1 mRNA
Gold results in increased expression of CDK1 mRNA

PMID:25523186 PMID:29705079

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin-dependent kinase 7

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of CDK7 mRNA

NCBI chr 2:31,840,558...31,865,422
Ensembl chr 2:31,840,558...31,865,383

G

cyclin-dependent kinase inhibitor 1B

multiple interactions

[Gold binds to Dimethyldithiocarbamate] which results in increased expression of CDKN1B protein

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

CDKN2A interacting protein

decreases expression

Gold results in decreased expression of CDKN2AIP mRNA

NCBI chr16:44,536,147...44,546,216
Ensembl chr16:44,536,234...44,540,033

G

cell growth regulator with ring finger domain 1

decreases expression

Gold results in decreased expression of CGRRF1 mRNA

NCBI chr15:20,088,564...20,109,042
Ensembl chr15:20,088,571...20,109,037

G

checkpoint kinase 1

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of CHEK1 mRNA
Gold analog results in decreased expression of CHEK1 mRNA

PMID:28433809 PMID:36057382

NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009

G

checkpoint kinase 2

decreases expression

Gold analog results in decreased expression of CHEK2 mRNA

NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286

G

cysteine and histidine rich domain containing 1

decreases expression

Gold results in decreased expression of CHORDC1 mRNA

NCBI chr 8:15,374,356...15,398,436
Ensembl chr 8:15,374,471...15,399,162

G

CDGSH iron sulfur domain 1

decreases expression

Gold results in decreased expression of CISD1 mRNA

NCBI chr20:17,255,302...17,268,688
Ensembl chr20:17,255,151...17,284,924

G

claudin 12

decreases expression

Gold results in decreased expression of CLDN12 mRNA

NCBI chr 4:28,522,659...28,533,647
Ensembl chr 4:28,522,678...28,533,801

G

CCHC-type zinc finger, nucleic acid binding protein

decreases expression

Gold results in decreased expression of CNBP mRNA

NCBI chr 4:120,302,768...120,311,694
Ensembl chr 4:120,302,771...120,311,637

G

CCR4-NOT transcription complex, subunit 7

decreases expression

Gold results in decreased expression of CNOT7 mRNA

NCBI chr16:51,775,416...51,794,581
Ensembl chr16:51,775,412...51,794,576

G

collagen type I alpha 1 chain

increases expression

Gold analog results in increased expression of COL1A1 protein

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type I alpha 2 chain

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of COL1A2 mRNA

NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867

G

collagen type III alpha 1 chain

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of COL3A1 mRNA

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

COMM domain containing 8

decreases expression

Gold results in decreased expression of COMMD8 mRNA

NCBI chr14:36,049,040...36,059,617
Ensembl chr14:36,049,004...36,059,617

G

cytochrome c oxidase copper chaperone COX11

decreases expression

Gold results in decreased expression of COX11 mRNA

NCBI chr10:75,458,735...75,465,322
Ensembl chr10:75,458,749...75,465,322

G

cytochrome c oxidase copper chaperone COX17

decreases expression

Gold results in decreased expression of COX17 mRNA

NCBI chr11:62,400,733...62,406,507

G

carnitine palmitoyltransferase 1A

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of CPT1A mRNA

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

carnitine palmitoyltransferase 2

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of CPT2 mRNA

NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095

G

carnitine O-octanoyltransferase

decreases expression

Gold analog results in decreased expression of CROT mRNA

NCBI chr 4:25,068,270...25,133,111
Ensembl chr 4:25,080,587...25,133,109

G

colony stimulating factor 2

multiple interactions
increases secretion

[Gold co-treated with Silicon Dioxide] results in increased secretion of CSF2 protein
Gold results in increased secretion of CSF2 protein

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

colony stimulating factor 3

increases secretion
multiple interactions

Gold results in increased secretion of CSF3 protein
[Gold co-treated with Silicon Dioxide] results in increased secretion of CSF3 protein

NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603

G

CCCTC-binding factor

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of CTCF mRNA

NCBI chr19:33,521,726...33,571,124
Ensembl chr19:33,529,319...33,571,123

G

cut-like homeobox 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of CUX1 mRNA

NCBI chr12:20,107,062...20,425,868
Ensembl chr12:20,107,311...20,425,866
Ensembl chr 4:20,107,311...20,425,866

G

C-X-C motif chemokine ligand 10

increases secretion
multiple interactions

Gold results in increased secretion of CXCL10 protein
[Gold co-treated with Silicon Dioxide] results in increased secretion of CXCL10 protein

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 2

multiple interactions
increases secretion

[Gold co-treated with Polyethylene Glycols] results in increased expression of CXCL2 mRNA; [Gold co-treated with Silicon Dioxide] results in increased secretion of CXCL2 protein
Gold results in increased secretion of CXCL2 protein

PMID:19695318 PMID:22155353

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine ligand 3

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of CXCL1 mRNA

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

cytochrome c, somatic

multiple interactions

[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which affects the localization of CYCS protein

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases activity
decreases expression
multiple interactions

Gold analog results in increased activity of CYP1A1 protein
Gold analog results in decreased expression of CYP1A1 mRNA
[Polyethyleneimine binds to Gold] which results in decreased expression of CYP1A1 mRNA

PMID:20193702 PMID:28433809 PMID:36057382

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 24, subfamily a, polypeptide 1

increases expression

Gold results in increased expression of CYP24A1 mRNA

NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383

G

cytochrome P450, family 2, subfamily d, polypeptide 4

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of CYP2D6 mRNA
Gold analog results in decreased expression of CYP2D6 mRNA

PMID:28433809 PMID:36057382

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases expression

Gold analog results in decreased expression of CYP2E1 mRNA

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450 family 7 subfamily A member 1

increases expression

Gold analog results in increased expression of CYP7A1 mRNA

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

cytohesin 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of CYTH1 mRNA

NCBI chr10:103,402,727...103,485,826
Ensembl chr10:103,366,145...103,485,760

G

DAB adaptor protein 2

increases expression

Gold results in increased expression of DAB2 mRNA

NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476

G

decapping mRNA 2

decreases expression

Gold results in decreased expression of DCP2 mRNA

NCBI chr18:36,750,732...36,787,067
Ensembl chr18:36,750,732...36,788,557

G

dopa decarboxylase

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of DDC mRNA

NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208

G

DNA-damage inducible transcript 3

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DNA-damage-inducible transcript 4

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of DDIT4 mRNA

NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105

G

defensin beta 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of DEFB1 mRNA

NCBI chr16:70,298,862...70,313,604
Ensembl chr16:70,298,863...70,313,604

G

24-dehydrocholesterol reductase

multiple interactions
decreases expression

[Gold co-treated with Polyethylene Glycols] results in decreased expression of DHCR24 mRNA
Gold analog results in decreased expression of DHCR24 mRNA
[Polyethyleneimine binds to Gold] which results in decreased expression of DHCR24 mRNA

PMID:19695318 PMID:28433809 PMID:36057382

NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137

G

dihydrolipoamide dehydrogenase

decreases expression

Gold analog results in decreased expression of DLD mRNA

NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795

G

dynein axonemal heavy chain 14

decreases expression

Gold results in decreased expression of DNAH14 mRNA

NCBI chr13:93,322,653...93,540,706
Ensembl chr13:93,322,711...93,538,646

G

DnaJ heat shock protein family (Hsp40) member A3

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of DNAJA3 mRNA

NCBI chr10:10,854,732...10,880,171
Ensembl chr10:10,854,732...10,880,161

G

DnaJ heat shock protein family (Hsp40) member B14

decreases expression

Gold results in decreased expression of DNAJB14 mRNA

NCBI chr 2:226,358,988...226,409,461
Ensembl chr 2:226,358,996...226,402,490

G

DnaJ heat shock protein family (Hsp40) member B6

decreases expression

Gold results in decreased expression of DNAJB6 mRNA

NCBI chr 4:5,452,683...5,556,679
Ensembl chr 4:5,452,683...5,556,659

G

DnaJ heat shock protein family (Hsp40) member B9

decreases expression

Gold results in decreased expression of DNAJB9 mRNA

NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063

G

DnaJ heat shock protein family (Hsp40) member C10

decreases expression

Gold results in decreased expression of DNAJC10 mRNA

NCBI chr 3:65,232,031...65,272,732
Ensembl chr 3:65,232,697...65,272,719

G

DnaJ heat shock protein family (Hsp40) member C19

decreases expression

Gold results in decreased expression of DNAJC19 mRNA

NCBI chr 2:116,923,272...116,945,312
Ensembl chr 2:116,923,272...116,945,264

G

DnaJ heat shock protein family (Hsp40) member C21

decreases expression

Gold results in decreased expression of DNAJC21 mRNA

NCBI chr 2:59,419,507...59,446,746
Ensembl chr 2:59,419,510...59,446,752

G

DnaJ heat shock protein family (Hsp40) member C5

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of DNAJC5 mRNA

NCBI chr 3:168,621,905...168,656,570
Ensembl chr 3:168,621,969...168,655,935

G

dihydropyrimidinase-like 4

increases expression

Gold analog results in increased expression of DPYSL4 mRNA

NCBI chr 1:193,883,039...193,898,916
Ensembl chr 1:193,883,106...193,898,914

G

dopamine receptor D3

multiple interactions

Gold inhibits the reaction [3-N-methylspiperone binds to DRD3 protein]

NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596

G

dopamine receptor D4

multiple interactions

Gold inhibits the reaction [3-N-methylspiperone binds to DRD4 protein]