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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:isocyanic acid
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Accession:CHEBI:29202 term browser browse the term
Definition:A colourless, volatile, poisonous inorganic compound with the formula HNCO; the simplest stable chemical compound that contains carbon, hydrogen, nitrogen, and oxygen, the four most commonly-found elements in organic chemistry and biology.
Synonyms:related_synonym: Formula=CHNO;   HN=C=O;   HNCO;   ICA;   InChI=1S/CHNO/c2-1-3/h2H;   InChIKey=OWIKHYCFFJSOEH-UHFFFAOYSA-N;   SMILES=N=C=O;   [C(NH)O];   carbimide;   hydrogen isocyanate;   isocyanate;   isocyansaeure;   isozyansaeure;   methenamide;   oxidoazanediidocarbon
 xref: Beilstein:1616281;   CAS:75-13-8;   Gmelin:840;   PMID:19494520;   PMID:26124058;   PMID:26760716;   PMID:977566;   Reaxys:1616281
 cyclic_relationship: is_conjugate_acid_of CHEBI:29195;   is_tautomer_of CHEBI:28024



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4-tolyl isocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il10 interleukin 10 increases expression ISO 4-tolyl isocyanate results in increased expression of IL10 mRNA CTD PMID:15664275 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il13 interleukin 13 increases expression ISO 4-tolyl isocyanate results in increased expression of IL13 mRNA CTD PMID:15664275 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il2 interleukin 2 increases expression ISO 4-tolyl isocyanate results in increased expression of IL2 protein CTD PMID:22381623 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 increases expression ISO 4-tolyl isocyanate results in increased expression of IL4 mRNA; 4-tolyl isocyanate results in increased expression of IL4 protein CTD PMID:15664275 PMID:22381623 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il4r interleukin 4 receptor increases expression ISO 4-tolyl isocyanate results in increased expression of IL4RA protein CTD PMID:22381623 NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980
JBrowse link
aldicarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP
ISO
Aldicarb results in decreased activity of ACHE protein CTD PMID:8134223 PMID:14644616 PMID:16256972 PMID:21251949 PMID:23962483 More... NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions EXP Aldicarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions EXP Aldicarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 8:55,418,379...55,436,967
Ensembl chr 8:55,418,313...55,437,027
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Aldicarb inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:9126867 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Il2 interleukin 2 decreases response to substance ISO Aldicarb results in decreased susceptibility to IL2 protein CTD PMID:8349949 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions ISO Aldicarb promotes the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of MAP2 mRNA] CTD PMID:32949729 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
JBrowse link
G Nefh neurofilament heavy chain increases phosphorylation ISO Aldicarb results in increased phosphorylation of NEFH protein CTD PMID:16256972 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
JBrowse link
G Nrxn1 neurexin 1 multiple interactions ISO NRXN1 protein affects the reaction [NLG-1 results in increased susceptibility to Aldicarb]; NRXN1 protein affects the reaction [NRX-1 results in decreased susceptibility to Aldicarb] CTD PMID:23638761 NCBI chr 6:3,177,788...4,323,848
Ensembl chr 6:3,177,897...4,322,710
JBrowse link
G Pax6 paired box 6 multiple interactions ISO Aldicarb inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of PAX6 mRNA] CTD PMID:32949729 NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Aldicarb inhibits the reaction [Progesterone results in increased activity of PGR protein] CTD PMID:9126867 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO
EXP
[Calcium results in increased activity of PON1 protein] which results in decreased susceptibility to Aldicarb; [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to Aldicarb CTD PMID:27132127 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Vpreb1 V-set pre-B cell surrogate light chain 1 decreases expression ISO Aldicarb results in decreased expression of VPREB1 mRNA CTD PMID:25424538 NCBI chr11:84,126,969...84,127,846
Ensembl chr11:84,126,969...84,127,846
JBrowse link
cyclohexyl isocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions EXP [cobaltous chloride results in increased activity of HIF1A protein] which results in decreased susceptibility to cyclohexylisocyanate CTD PMID:14980978 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
dicyclohexylmethane-4,4'-diisocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il10 interleukin 10 increases expression ISO methylene bis(4-cyclohexylisocyanate) results in increased expression of IL10 mRNA CTD PMID:16940033 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il13 interleukin 13 increases expression ISO methylene bis(4-cyclohexylisocyanate) results in increased expression of IL13 mRNA CTD PMID:16940033 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il4 interleukin 4 increases expression ISO methylene bis(4-cyclohexylisocyanate) results in increased expression of IL4 mRNA CTD PMID:16940033 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
diphenylmethane-4,4'-diisocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions
affects binding
EXP
ISO
[4,4'-diphenylmethane diisocyanate binds to ALB protein] which results in increased chemical synthesis of N6-(((4-(4-(acetylamino)benzyl)phenyl)amino)carbonyl)lysine; [4,4'-diphenylmethane diisocyanate binds to ALB protein] which results in increased chemical synthesis of N6-(((4-(4-aminobenzyl)phenyl)amino)carbonyl)lysine
[4,4'-diphenylmethane diisocyanate co-treated with Glutathione] binds to and results in increased metabolism of ALB protein
CTD PMID:19928878 PMID:23791970 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Cd86 CD86 molecule increases expression ISO 4,4'-diphenylmethane diisocyanate results in increased expression of CD86 protein CTD PMID:19665512 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases response to substance ISO GSTM1 protein polymorphism results in increased susceptibility to 4,4'-diphenylmethane diisocyanate CTD PMID:11927838 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO 4,4'-diphenylmethane diisocyanate results in increased expression of ICAM1 protein CTD PMID:11698162 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il10 interleukin 10 increases expression ISO 4,4'-diphenylmethane diisocyanate results in increased expression of IL10 mRNA CTD PMID:16940033 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il13 interleukin 13 increases expression ISO 4,4'-diphenylmethane diisocyanate results in increased expression of IL13 mRNA CTD PMID:16940033 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il2 interleukin 2 increases expression ISO 4,4'-diphenylmethane diisocyanate results in increased expression of IL2 protein CTD PMID:22381623 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 increases expression ISO 4,4'-diphenylmethane diisocyanate results in increased expression of IL4 mRNA; 4,4'-diphenylmethane diisocyanate results in increased expression of IL4 protein CTD PMID:11708898 PMID:16940033 PMID:22381623 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il4r interleukin 4 receptor increases expression ISO 4,4'-diphenylmethane diisocyanate results in increased expression of IL4RA protein CTD PMID:22381623 NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980
JBrowse link
G Mir206 microRNA 206 multiple interactions
decreases expression
ISO [[4,4'-diphenylmethane diisocyanate results in decreased expression of MIR206] which results in increased expression of PPP3CA mRNA] which results in increased expression of NOS2 mRNA CTD PMID:31609387 NCBI chr 9:23,094,249...23,094,332
Ensembl chr 9:23,094,249...23,094,332
JBrowse link
G Mir381 microRNA 381 multiple interactions
decreases expression
ISO [[4,4'-diphenylmethane diisocyanate results in decreased expression of MIR381] which results in increased expression of PPP3CA mRNA] which results in increased expression of NOS2 mRNA CTD PMID:31609387 NCBI chr 6:128,740,976...128,741,036 JBrowse link
G Nat1 N-acetyltransferase 1 increases response to substance ISO NAT1 protein polymorphism results in increased susceptibility to 4,4'-diphenylmethane diisocyanate CTD PMID:11927838 NCBI chr16:22,218,217...22,238,516 JBrowse link
G Nat2 N-acetyltransferase 2 increases response to substance ISO NAT2 protein polymorphism results in increased susceptibility to 4,4'-diphenylmethane diisocyanate CTD PMID:11927838 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
ISO [[4,4'-diphenylmethane diisocyanate results in decreased expression of MIR206] which results in increased expression of PPP3CA mRNA] which results in increased expression of NOS2 mRNA; [[4,4'-diphenylmethane diisocyanate results in decreased expression of MIR381] which results in increased expression of PPP3CA mRNA] which results in increased expression of NOS2 mRNA
4,4'-diphenylmethane diisocyanate results in increased expression of NOS2 mRNA
CTD PMID:31609387 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha increases expression
multiple interactions
ISO 4,4'-diphenylmethane diisocyanate results in increased expression of PPP3CA mRNA
[[4,4'-diphenylmethane diisocyanate results in decreased expression of MIR206] which results in increased expression of PPP3CA mRNA] which results in increased expression of NOS2 mRNA; [[4,4'-diphenylmethane diisocyanate results in decreased expression of MIR381] which results in increased expression of PPP3CA mRNA] which results in increased expression of NOS2 mRNA
CTD PMID:31609387 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
JBrowse link
hexamethylene diisocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ampd3 adenosine monophosphate deaminase 3 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of AMPD3 mRNA CTD PMID:24211530 NCBI chr 1:164,884,823...164,929,899
Ensembl chr 1:164,885,320...164,929,887
JBrowse link
G Atox1 antioxidant 1 copper chaperone increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of ATOX1 promoter CTD PMID:25445006 NCBI chr10:39,564,855...39,579,892
Ensembl chr10:39,564,857...39,579,950
JBrowse link
G Atp8a2 ATPase phospholipid transporting 8A2 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of ATP8A2 gene CTD PMID:25445006 NCBI chr15:33,817,309...34,350,193
Ensembl chr15:33,819,755...34,350,223
JBrowse link
G Atp9b ATPase phospholipid transporting 9B (putative) increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of ATP9B gene CTD PMID:25445006 NCBI chr18:74,176,863...74,368,993
Ensembl chr18:74,176,863...74,368,953
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of CACNA1H gene CTD PMID:25445006 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376
JBrowse link
G Dhx29 DExH-box helicase 29 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of DHX29 mRNA CTD PMID:19527780 NCBI chr 2:44,560,653...44,611,450
Ensembl chr 2:44,560,714...44,611,445
JBrowse link
G Dscaml1 DS cell adhesion molecule-like 1 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of DSCAML1 gene CTD PMID:25445006 NCBI chr 8:45,740,298...46,057,322
Ensembl chr 8:45,740,298...46,057,320
JBrowse link
G Ebag9 estrogen receptor binding site associated, antigen, 9 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of EBAG9 gene CTD PMID:25445006 NCBI chr 7:75,810,950...75,828,902
Ensembl chr 7:75,810,594...75,861,248
JBrowse link
G Fam210a family with sequence similarity 210, member A increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of FAM210A promoter CTD PMID:25445006 NCBI chr18:61,846,447...61,886,123
Ensembl chr18:61,852,907...61,886,171
JBrowse link
G Farp1 FERM, ARH/RhoGEF and pleckstrin domain protein 1 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of FARP1 gene CTD PMID:25445006 NCBI chr15:98,124,304...98,363,299
Ensembl chr15:98,182,329...98,363,299
JBrowse link
G Fbxw4 F-box and WD repeat domain containing 4 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of FBXW4 gene CTD PMID:25445006 NCBI chr 1:244,426,892...244,514,188
Ensembl chr 1:244,426,896...244,514,163
JBrowse link
G Fth1 ferritin heavy chain 1 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of FTH1 mRNA CTD PMID:24211530 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of FTL mRNA CTD PMID:24211530 NCBI chr 1:95,936,390...95,938,234
Ensembl chr 1:95,936,387...95,939,725
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of GCLM mRNA CTD PMID:24211530 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gnrhr gonadotropin releasing hormone receptor affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of GNRHR mRNA CTD PMID:19527780 NCBI chr14:21,856,871...21,874,861
Ensembl chr14:21,856,871...21,874,861
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases response to substance ISO GSTM1 protein polymorphism results in increased susceptibility to 1,6-hexamethylene diisocyanate CTD PMID:11927838 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gypc glycophorin C (Gerbich blood group) increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of GYPC gene CTD PMID:25445006 NCBI chr18:24,160,738...24,193,408
Ensembl chr18:24,160,739...24,193,204
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of HMOX1 mRNA CTD PMID:24211530 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of ICAM1 protein CTD PMID:11698162 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of IFNG protein CTD PMID:12884401 PMID:19422874 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of IL10 protein CTD PMID:12884401 PMID:19422874 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il13 interleukin 13 increases secretion ISO 1,6-hexamethylene diisocyanate results in increased secretion of IL13 protein CTD PMID:17693426 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il22ra2 interleukin 22 receptor subunit alpha 2 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of IL22RA2 gene CTD PMID:25445006 NCBI chr 1:14,353,736...14,377,844
Ensembl chr 1:14,364,489...14,377,844
JBrowse link
G Il4 interleukin 4 increases expression
increases secretion
ISO 1,6-hexamethylene diisocyanate results in increased expression of IL4 protein
1,6-hexamethylene diisocyanate results in increased secretion of IL4 protein
CTD PMID:12884401 PMID:17693426 PMID:19422874 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il5 interleukin 5 increases secretion ISO 1,6-hexamethylene diisocyanate results in increased secretion of IL5 protein CTD PMID:17693426 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of ISG20 promoter CTD PMID:25445006 NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027
JBrowse link
G Islr2 immunoglobulin superfamily containing leucine-rich repeat 2 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of ISLR2 gene CTD PMID:25445006 NCBI chr 8:58,608,165...58,616,246
Ensembl chr 8:58,608,709...58,614,650
JBrowse link
G Kitlg KIT ligand affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of KITLG mRNA CTD PMID:19110044 NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214
JBrowse link
G Lca5l lebercilin LCA5 like increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of LCA5L gene CTD PMID:25445006 NCBI chr11:35,460,648...35,495,133
Ensembl chr11:35,461,118...35,495,047
JBrowse link
G Ldha lactate dehydrogenase A affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of LDHA mRNA CTD PMID:19110044 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
JBrowse link
G LOC686035 similar to heat shock 70kDa protein 6 (HSP70B) affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of HSPA6 mRNA CTD PMID:19110044 NCBI chr13:83,271,340...83,275,267 JBrowse link
G LOC686596 similar to aquaporin 10 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of AQP10 mRNA CTD PMID:19527780 NCBI chr 2:175,402,609...175,407,677
Ensembl chr 2:175,403,263...175,406,815
JBrowse link
G Lrrn4 leucine rich repeat neuronal 4 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of LRRN4 gene CTD PMID:25445006 NCBI chr 3:120,138,093...120,150,877
Ensembl chr 3:120,139,410...120,150,831
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO 1,6-hexamethylene diisocyanate promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
1,6-hexamethylene diisocyanate results in increased phosphorylation of MAPK1 protein
CTD PMID:27129696 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO 1,6-hexamethylene diisocyanate promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
1,6-hexamethylene diisocyanate results in increased phosphorylation of MAPK3 protein
CTD PMID:27129696 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
ISO 1,6-hexamethylene diisocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]
1,6-hexamethylene diisocyanate results in increased phosphorylation of MAPK8 protein
CTD PMID:27129696 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation
multiple interactions
ISO 1,6-hexamethylene diisocyanate results in increased phosphorylation of MAPK9 protein
1,6-hexamethylene diisocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]
CTD PMID:27129696 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mrpl58 mitochondrial ribosomal protein L58 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of MRPL58 gene CTD PMID:25445006 NCBI chr10:100,646,374...100,652,871
Ensembl chr10:100,646,216...100,652,871
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of MYC mRNA CTD PMID:24211530 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nab2 Ngfi-A binding protein 2 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of NAB2 gene CTD PMID:25445006 NCBI chr 7:63,497,589...63,504,105
Ensembl chr 7:63,497,589...63,503,989
JBrowse link
G Nat1 N-acetyltransferase 1 increases response to substance ISO NAT1 protein polymorphism results in increased susceptibility to 1,6-hexamethylene diisocyanate CTD PMID:11927838 NCBI chr16:22,218,217...22,238,516 JBrowse link
G Nat2 N-acetyltransferase 2 increases response to substance ISO NAT2 protein polymorphism results in increased susceptibility to 1,6-hexamethylene diisocyanate CTD PMID:11927838 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
JBrowse link
G Nexn nexilin (F actin binding protein) affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of NEXN mRNA CTD PMID:19527780 NCBI chr 2:241,186,783...241,218,315
Ensembl chr 2:241,186,790...241,218,342
JBrowse link
G Nmbr neuromedin B receptor increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of NMBR gene CTD PMID:25445006 NCBI chr 1:9,115,033...9,146,081
Ensembl chr 1:9,134,889...9,145,462
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of NQO1 mRNA CTD PMID:24211530 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Olr1433 olfactory receptor 1433 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of OR2W3 mRNA CTD PMID:19527780 NCBI chr10:43,042,427...43,046,293
Ensembl chr10:43,037,857...43,046,701
JBrowse link
G Osbp2 oxysterol binding protein 2 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of OSBP2 mRNA CTD PMID:19527780 NCBI chr14:78,585,088...78,746,785
Ensembl chr14:78,585,089...78,746,786
JBrowse link
G Rnmt RNA (guanine-7-) methyltransferase increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of RNMT promoter CTD PMID:25445006 NCBI chr18:61,886,230...61,909,775
Ensembl chr18:61,886,292...61,909,775
JBrowse link
G Sel1l3 SEL1L family member 3 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of SEL1L3 mRNA CTD PMID:24211530 NCBI chr14:57,775,515...57,882,076
Ensembl chr14:57,775,501...57,882,644
JBrowse link
G Slc16a4 solute carrier family 16, member 4 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of SLC16A4 mRNA CTD PMID:19110044 NCBI chr 2:194,911,075...194,933,162
Ensembl chr 2:194,911,236...194,933,117
JBrowse link
G Slc25a28 solute carrier family 25 member 28 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of SLC25A28 gene CTD PMID:25445006 NCBI chr 1:242,530,877...242,542,140
Ensembl chr 1:242,530,899...242,542,115
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of SLC7A11 mRNA CTD PMID:24211530 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Socs3 suppressor of cytokine signaling 3 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of SOCS3 mRNA CTD PMID:19110044 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
JBrowse link
G Specc1 sperm antigen with calponin homology and coiled-coil domains 1 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of SPECC1 gene CTD PMID:25445006 NCBI chr10:46,638,947...46,912,989
Ensembl chr10:46,638,809...46,912,802
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of SQSTM1 mRNA CTD PMID:24211530 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Stc1 stanniocalcin 1 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of STC1 mRNA CTD PMID:19527780 NCBI chr15:44,299,591...44,311,695
Ensembl chr15:44,299,621...44,310,264
JBrowse link
G Syne2 spectrin repeat containing nuclear envelope protein 2 decreases expression ISO 1,6-hexamethylene diisocyanate results in decreased expression of SYNE2 mRNA CTD PMID:24211530 NCBI chr 6:94,537,088...94,848,085 JBrowse link
G Tlr2 toll-like receptor 2 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of TLR2 mRNA CTD PMID:19110044 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tmem253 transmembrane protein 253 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of TMEM253 promoter CTD PMID:25445006 NCBI chr15:24,706,517...24,709,107
Ensembl chr15:24,706,529...24,708,625
JBrowse link
G Tnnt2 troponin T2, cardiac type decreases expression ISO 1,6-hexamethylene diisocyanate results in decreased expression of TNNT2 mRNA CTD PMID:24211530 NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of TXNRD1 mRNA CTD PMID:24211530 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Uba2 ubiquitin-like modifier activating enzyme 2 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of UBA2 mRNA CTD PMID:19527780 NCBI chr 1:86,775,239...86,802,685
Ensembl chr 1:86,775,244...86,802,682
JBrowse link
G Ube2e1 ubiquitin-conjugating enzyme E2E 1 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of UBE2E1 promoter CTD PMID:25445006 NCBI chr15:7,439,502...7,493,410
Ensembl chr15:7,439,759...7,493,400
JBrowse link
G Zfp219 zinc finger protein 219 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of ZNF219 promoter CTD PMID:25445006 NCBI chr15:24,695,831...24,710,039
Ensembl chr15:24,695,837...24,710,030
JBrowse link
isocyanates term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase increases expression
increases phosphorylation
ISO Isocyanates results in increased expression of ATM protein
Isocyanates analog results in increased phosphorylation of ATM protein
[Isocyanates results in increased phosphorylation of ATM protein] which results in increased phosphorylation of H2AX protein; Isocyanates results in increased phosphorylation of ATM protein
CTD PMID:19111005 PMID:19197993 PMID:19283680 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atr ATR serine/threonine kinase increases expression ISO Isocyanates results in increased expression of ATR protein CTD PMID:19283680 NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Isocyanates results in increased expression of CDKN1A protein CTD PMID:20685613 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO Isocyanates results in increased expression of CDKN2A protein CTD PMID:20685613 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity ISO Isocyanates analog results in decreased activity of GSR protein CTD PMID:19111005 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G H2ax H2A.X variant histone increases expression
increases phosphorylation
ISO Isocyanates results in increased expression of H2AX protein
[Isocyanates results in increased phosphorylation of ATM protein] which results in increased phosphorylation of H2AX protein
Isocyanates analog results in increased phosphorylation of H2AX protein
CTD PMID:19111005 PMID:19197993 PMID:19283680 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Ifng interferon gamma increases expression ISO Isocyanates analog results in increased expression of IFNG protein CTD PMID:19111005 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il12a interleukin 12A increases expression ISO Isocyanates analog results in increased expression of IL12A protein CTD PMID:19111005 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B increases expression ISO Isocyanates analog results in increased expression of IL12B protein CTD PMID:19111005 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il1b interleukin 1 beta increases expression ISO Isocyanates analog results in increased expression of IL1B protein CTD PMID:19111005 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 increases expression ISO Isocyanates analog results in increased expression of IL6 protein CTD PMID:19111005 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease increases expression ISO Isocyanates results in increased expression of MRE11A protein CTD PMID:20685613 NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279
JBrowse link
G Rad50 RAD50 double strand break repair protein increases expression ISO Isocyanates results in increased expression of RAD50 protein CTD PMID:20685613 NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396
JBrowse link
G Rb1 RB transcriptional corepressor 1 increases expression ISO Isocyanates results in increased expression of RB1 protein CTD PMID:20685613 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Terf2 telomeric repeat binding factor 2 decreases expression ISO Isocyanates results in decreased expression of TERF2 protein CTD PMID:20685613 NCBI chr19:34,976,963...35,005,813
Ensembl chr19:34,977,471...35,005,819
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Isocyanates analog results in increased expression of TNF protein CTD PMID:19111005 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 increases expression ISO Isocyanates results in increased expression of TP53 protein CTD PMID:19283680 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases response to substance ISO TRPA1 protein results in increased susceptibility to Isocyanates CTD PMID:19036859 NCBI chr 5:4,379,999...4,433,243
Ensembl chr 5:4,379,999...4,433,570
JBrowse link
isophorone diisocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il10 interleukin 10 increases expression ISO isophorone diisocyanate results in increased expression of IL10 protein CTD PMID:19422874 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il13 interleukin 13 increases secretion ISO isophorone diisocyanate results in increased secretion of IL13 protein CTD PMID:17693426 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO isophorone diisocyanate results in decreased expression of IL1B mRNA CTD PMID:29594315 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [isophorone diisocyanate co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 increases expression
increases secretion
ISO isophorone diisocyanate results in increased expression of IL4 protein
isophorone diisocyanate results in increased secretion of IL4 protein
CTD PMID:17693426 PMID:19422874 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects response to substance ISO NFE2L2 affects the susceptibility to isophorone diisocyanate CTD PMID:23564646 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
methyl isocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aurka aurora kinase A affects expression ISO methyl isocyanate affects the expression of AURKA mRNA CTD PMID:22223508 NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390
JBrowse link
G Aurkb aurora kinase B increases expression ISO methyl isocyanate results in increased expression of AURKB protein CTD PMID:22223508 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
JBrowse link
G Ccne1 cyclin E1 affects expression ISO methyl isocyanate affects the expression of CCNE1 protein CTD PMID:19513903 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Cdk2 cyclin dependent kinase 2 affects expression
increases expression
ISO methyl isocyanate affects the expression of CDK2 protein
methyl isocyanate results in increased expression of CDK2 protein
CTD PMID:19513903 PMID:22223508 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A affects expression ISO methyl isocyanate affects the expression of CDKN1A protein CTD PMID:19513903 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO methyl isocyanate results in increased expression of CHEK1 mRNA CTD PMID:22223508 NCBI chr 8:36,420,565...36,443,477 JBrowse link
G Chek2 checkpoint kinase 2 decreases expression ISO methyl isocyanate results in decreased expression of CHEK2 mRNA CTD PMID:22223508 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Ifng interferon gamma increases expression ISO methyl isocyanate results in increased expression of IFNG protein CTD PMID:19295137 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 increases expression ISO methyl isocyanate results in increased expression of IL10 protein CTD PMID:19295137 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il2 interleukin 2 increases expression ISO methyl isocyanate results in increased expression of IL2 protein CTD PMID:19295137 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 increases expression ISO methyl isocyanate results in increased expression of IL4 protein CTD PMID:19295137 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases activity ISO methyl isocyanate results in decreased activity of MGMT protein CTD PMID:14685775 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
JBrowse link
G Pcnt pericentrin increases expression ISO methyl isocyanate results in increased expression of PCNT protein CTD PMID:22223508 NCBI chr20:12,190,597...12,278,723
Ensembl chr20:12,191,648...12,278,710
JBrowse link
G Pot1 protection of telomeres 1 decreases expression ISO methyl isocyanate results in decreased expression of POT1A protein CTD PMID:22223508 NCBI chr 4:54,205,330...54,263,137
Ensembl chr 4:54,205,332...54,263,042
JBrowse link
G Slc4a1 solute carrier family 4 member 1 (Diego blood group) multiple interactions EXP methyl isocyanate binds to and results in increased degradation of SLC4A1 protein CTD PMID:8935787 NCBI chr10:87,306,865...87,323,132
Ensembl chr10:87,306,872...87,323,117
JBrowse link
G Tp53 tumor protein p53 affects expression
decreases expression
ISO methyl isocyanate affects the expression of TP53 protein
methyl isocyanate results in decreased expression of TRP53 protein
CTD PMID:19513903 PMID:22223508 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
phenyl isocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Krt1 keratin 1 affects binding ISO phenyl isocyanate analog binds to KRT1 protein CTD PMID:26070416 NCBI chr 7:132,976,618...132,981,844
Ensembl chr 7:132,976,620...132,981,844
JBrowse link
G Krt14 keratin 14 affects binding ISO phenyl isocyanate analog binds to KRT14 protein CTD PMID:26070416 NCBI chr10:85,137,932...85,141,990
Ensembl chr10:85,066,802...85,171,799
JBrowse link
G Krt16 keratin 16 affects binding ISO phenyl isocyanate analog binds to KRT16 protein CTD PMID:26070416 NCBI chr10:85,168,357...85,171,744 JBrowse link
G Krt5 keratin 5 affects binding ISO phenyl isocyanate analog binds to KRT5 protein CTD PMID:26070416 NCBI chr 7:132,846,355...132,851,986
Ensembl chr 7:132,846,136...132,851,850
JBrowse link
G Krt9 keratin 9 affects binding ISO phenyl isocyanate analog binds to KRT9 protein CTD PMID:26070416 NCBI chr10:85,120,962...85,127,228
Ensembl chr10:85,122,424...85,127,228
JBrowse link
toluene 2,4-diisocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acyp1 acylphosphatase 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of ACYP1 mRNA CTD PMID:11379042 NCBI chr 6:104,919,162...104,932,348
Ensembl chr 6:104,919,162...104,932,387
JBrowse link
G Adamts15 ADAM metallopeptidase with thrombospondin type 1 motif, 15 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of ADAMTS15 mRNA CTD PMID:19647056 NCBI chr 8:29,307,864...29,331,249
Ensembl chr 8:29,307,865...29,331,249
JBrowse link
G Adcy6 adenylate cyclase 6 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of ADCY6 mRNA CTD PMID:11379042 NCBI chr 7:129,742,827...129,763,922
Ensembl chr 7:129,742,838...129,763,754
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions
increases expression
ISO FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of AGER protein]; pyrazolanthrone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of AGER protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of AGER protein]
AGER protein affects the reaction [Toluene 2,4-Diisocyanate analog affects the localization of CTNNB1 protein]; FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of AGER protein]; pyrazolanthrone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of AGER protein]
CTD PMID:28329851 PMID:30261222 PMID:33075463 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of AKT1 protein] CTD PMID:26089345 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alb albumin multiple interactions
affects binding
ISO [Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CCL5 protein; [Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein; [Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CXCL8 protein; [Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of KRT14 mRNA; [Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of KRT19 mRNA; [Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased phosphorylation of MAPK1 protein; [Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased phosphorylation of MAPK3 protein; Dexamethasone inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CCL5 protein]; Dexamethasone inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein]; Dexamethasone inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CXCL8 protein]; EGFR protein affects the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CCL5 protein]; EGFR protein affects the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein]; EGFR protein affects the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CXCL8 protein]; IL1B protein affects the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CXCL8 protein]; RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein]; RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CXCL8 protein]; RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased phosphorylation of MAPK3 protein]; SB 203580 inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CCL5 protein]; SB 203580 inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein]; SB 203580 inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CXCL8 protein] CTD PMID:9124697 PMID:14676436 PMID:15478392 PMID:16908450 PMID:17030242 More... NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Ankrd2 ankyrin repeat domain 2 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of ANKRD2 mRNA CTD PMID:19647056 NCBI chr 1:240,847,111...240,856,563
Ensembl chr 1:240,847,072...240,856,566
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of ASNS mRNA CTD PMID:18242016 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
JBrowse link
G Axl Axl receptor tyrosine kinase decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of AXL mRNA CTD PMID:11379042 NCBI chr 1:81,265,656...81,296,278
Ensembl chr 1:81,265,088...81,296,265
JBrowse link
G Bpifa2 BPI fold containing family A, member 2 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of BPIFA2 mRNA CTD PMID:11379042 NCBI chr 3:142,493,379...142,501,343
Ensembl chr 3:142,493,379...142,501,337
JBrowse link
G Bspry B-box and SPRY domain containing increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of BSPRY mRNA CTD PMID:18242016 NCBI chr 5:75,927,397...75,949,585
Ensembl chr 5:75,927,405...75,949,583
JBrowse link
G Bst2 bone marrow stromal cell antigen 2 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of BST2 mRNA CTD PMID:19647056 NCBI chr16:18,217,404...18,220,979
Ensembl chr16:18,217,407...18,220,979
JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of BUB1 mRNA CTD PMID:21404309 NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650
JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of BUB1B mRNA CTD PMID:21404309 NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547
JBrowse link
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CACNB3 mRNA CTD PMID:11379042 NCBI chr 7:129,784,799...129,797,074
Ensembl chr 7:129,783,674...129,797,074
JBrowse link
G Cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CAD mRNA CTD PMID:21404309 NCBI chr 6:25,292,133...25,315,176
Ensembl chr 6:25,292,133...25,319,861
JBrowse link
G Casp1 caspase 1 multiple interactions
increases expression
increases cleavage
ISO 1-(2-((1-(4-amino-3-chlorophenyl)methanoyl)amino)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxylic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CASP1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased cleavage of CASP1 protein]; L 709049 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CASP1 protein]; MCC-950 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CASP1 protein] CTD PMID:25929181 PMID:31070765 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Cav1 caveolin 1 multiple interactions
increases phosphorylation
ISO AG 1879 inhibits the reaction [Toluene 2,4-Diisocyanate analog results in increased phosphorylation of CAV1 protein]; CAV1 protein mutant form inhibits the reaction [Toluene 2,4-Diisocyanate analog affects the localization of CTNNB1 protein]; CAV1 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of ENPP2 protein]; FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate analog results in increased phosphorylation of CAV1 protein]
FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of CAV1 protein]
CTD PMID:29940203 PMID:30261222 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions
increases expression
ISO
EXP
BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL11 protein]; pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL11 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL11 protein]; rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL11 protein]
Toluene 2,4-Diisocyanate results in increased expression of CCL11 mRNA
CTD PMID:15823807 PMID:17015710 PMID:20219652 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
JBrowse link
G Ccl12 chemokine (C-C motif) ligand 12 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CCL12 mRNA CTD PMID:19647056 NCBI chr10:67,070,230...67,071,780
Ensembl chr10:67,070,230...67,071,780
JBrowse link
G Ccl17 C-C motif chemokine ligand 17 multiple interactions
increases expression
ISO diflorasone promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL17 protein]
Toluene 2,4-Diisocyanate results in increased expression of CCL17 mRNA; Toluene 2,4-Diisocyanate results in increased expression of CCL17 protein
CTD PMID:15491423 PMID:21404309 NCBI chr19:10,202,317...10,203,768
Ensembl chr19:10,202,128...10,203,819
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions
ISO Toluene 2,4-Diisocyanate results in increased expression of CCL2 mRNA; Toluene 2,4-Diisocyanate results in increased expression of CCL2 protein
CCL2 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased secretion of ENPP2 protein]
CTD PMID:19647056 PMID:20219652 PMID:21404309 PMID:26072274 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl22 C-C motif chemokine ligand 22 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CCL22 mRNA CTD PMID:21404309 NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CCL3 mRNA CTD PMID:19647056 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CCL4 mRNA; Toluene 2,4-Diisocyanate results in increased expression of CCL4 protein CTD PMID:19647056 PMID:20219652 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 affects response to substance
decreases expression
increases expression
multiple interactions
ISO
EXP
CCL5 gene polymorphism affects the susceptibility to Toluene 2,4-Diisocyanate
Toluene 2,4-Diisocyanate results in decreased expression of CCL5 mRNA
Toluene 2,4-Diisocyanate results in increased expression of CCL5 mRNA
Toluene 2,4-Diisocyanate results in increased expression of CCL5 mRNA; Toluene 2,4-Diisocyanate results in increased expression of CCL5 protein
BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL5 protein]; Cilomilast inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL5 protein]; diflorasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL5 protein]; pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL5 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL5 protein]; rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL5 protein]; TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL5 mRNA]
[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CCL5 protein; Dexamethasone inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CCL5 protein]; EGFR protein affects the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CCL5 protein]; SB 203580 inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CCL5 protein]
CTD PMID:11467998 PMID:12356572 PMID:15491423 PMID:15823807 PMID:16908450 More... NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccl6 C-C motif chemokine ligand 6 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CCL6 mRNA CTD PMID:19647056 PMID:21404309 NCBI chr10:68,381,179...68,385,811
Ensembl chr10:68,380,188...68,384,001
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CCL7 mRNA CTD PMID:19647056 PMID:21404309 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
JBrowse link
G Ccna2 cyclin A2 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CCNA2 mRNA CTD PMID:21404309 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb2 cyclin B2 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CCNB2 mRNA CTD PMID:21404309 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
JBrowse link
G Ccne1 cyclin E1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CCNE1 mRNA CTD PMID:21404309 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Ccnf cyclin F increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CCNF mRNA CTD PMID:18242016 NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CCR2 mRNA CTD PMID:19647056 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
JBrowse link
G Ccr6 C-C motif chemokine receptor 6 increases expression
decreases expression
ISO Toluene 2,4-Diisocyanate results in increased expression of CCR6 protein
Toluene 2,4-Diisocyanate results in decreased expression of CCR6 mRNA
CTD PMID:21404309 PMID:27103660 NCBI chr 1:52,474,477...52,508,301
Ensembl chr 1:52,474,168...52,498,603
JBrowse link
G Cd24 CD24 molecule decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of CD24A mRNA CTD PMID:21404309 NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662
JBrowse link
G Cd36 CD36 molecule decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of CD36 mRNA CTD PMID:21404309 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Cd4 Cd4 molecule multiple interactions ISO CD4 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IFNG mRNA]; CD4 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 mRNA]; CD4 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; CD4 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 mRNA] CTD PMID:15590890 NCBI chr 4:157,668,878...157,695,366 JBrowse link
G Cd40 CD40 molecule increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CD40 mRNA CTD PMID:19647056 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Cd47 Cd47 molecule decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of CD47 mRNA CTD PMID:11379042 NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425
JBrowse link
G Cd55 CD55 molecule (Cromer blood group) decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of CD55 mRNA CTD PMID:21404309 NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831
JBrowse link
G Cd8b CD8b molecule decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of CD8B1 mRNA CTD PMID:21404309 NCBI chr 4:103,312,596...103,328,523
Ensembl chr 4:103,312,578...103,328,553
JBrowse link
G Cdc20 cell division cycle 20 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CDC20 mRNA CTD PMID:21404309 NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
JBrowse link
G Cdc25a cell division cycle 25A increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CDC25A mRNA CTD PMID:21404309 NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
JBrowse link
G Cdc25b cell division cycle 25B increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CDC25B mRNA CTD PMID:21404309 NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272
JBrowse link
G Cdc25c cell division cycle 25C increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CDC25C mRNA CTD PMID:21404309 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
JBrowse link
G Cdc45 cell division cycle 45 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CDC45 mRNA CTD PMID:21404309 NCBI chr11:82,185,427...82,210,630
Ensembl chr11:82,185,473...82,210,619
JBrowse link
G Cdc6 cell division cycle 6 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CDC6 mRNA CTD PMID:21404309 NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011
JBrowse link
G Cdc7 cell division cycle 7 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CDC7 mRNA CTD PMID:21404309 NCBI chr14:2,804,660...2,824,796
Ensembl chr14:2,804,661...2,824,778
JBrowse link
G Cdca2 cell division cycle associated 2 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CDCA2 mRNA CTD PMID:18242016 NCBI chr15:41,895,946...41,942,226
Ensembl chr15:41,895,901...41,941,611
JBrowse link
G Cdh1 cadherin 1 multiple interactions
affects localization
ISO 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Toluene 2,4-Diisocyanate affects the localization of CDH1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate affects the localization of CDH1 protein]; GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate affects the localization of CDH1 protein]; Toluene 2,4-Diisocyanate results in decreased expression of and affects the localization of CDH1 protein CTD PMID:26089345 PMID:30517707 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CDK1 mRNA CTD PMID:21404309 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CDK2 mRNA CTD PMID:21404309 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CDKN1A mRNA CTD PMID:21404309 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of CDKN1B mRNA CTD PMID:21404309 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of CDKN1C mRNA CTD PMID:21404309 NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048
JBrowse link
G Cntf ciliary neurotrophic factor increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CNTF mRNA CTD PMID:21404309 NCBI chr 1:209,887,854...209,889,877
Ensembl chr 1:209,887,854...209,889,877
JBrowse link
G Commd3 COMM domain containing 3 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of COMMD3 mRNA CTD PMID:21404309 NCBI chr17:81,327,451...81,331,183
Ensembl chr17:81,327,405...81,331,177
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO [Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein; Dexamethasone inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein]; EGFR protein affects the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein]; RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein]; SB 203580 inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein] CTD PMID:16908450 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Csf2rb colony stimulating factor 2 receptor subunit beta increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CSF2RB2 mRNA CTD PMID:19647056 NCBI chr 7:109,876,919...109,901,589
Ensembl chr 7:109,886,425...109,904,157
JBrowse link
G Csf3r colony stimulating factor 3 receptor increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CSF3R mRNA CTD PMID:19647056 NCBI chr 5:138,298,605...138,318,224
Ensembl chr 5:138,301,506...138,317,881
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CTLA4 protein CTD PMID:27103660 NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
affects localization
increases phosphorylation
ISO 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of and results in increased activity of and affects the localization of CTNNB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in decreased expression of and affects the localization of CTNNB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of CTNNB1 protein]; AG 1879 inhibits the reaction [Toluene 2,4-Diisocyanate affects the localization of CTNNB1 protein]; FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate affects the localization of CTNNB1 protein]; GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of and results in increased activity of and affects the localization of CTNNB1 protein]; Toluene 2,4-Diisocyanate results in decreased expression of and affects the localization of CTNNB1 protein; Toluene 2,4-Diisocyanate results in increased phosphorylation of and results in increased activity of and affects the localization of CTNNB1 protein
Toluene 2,4-Diisocyanate analog affects the localization of CTNNB1 protein
AG 1879 inhibits the reaction [Toluene 2,4-Diisocyanate analog affects the localization of CTNNB1 protein]; AGER protein affects the reaction [Toluene 2,4-Diisocyanate analog affects the localization of CTNNB1 protein]; CAV1 protein mutant form inhibits the reaction [Toluene 2,4-Diisocyanate analog affects the localization of CTNNB1 protein]; FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate analog affects the localization of CTNNB1 protein]
CTD PMID:26089345 PMID:30261222 PMID:30517707 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CXCL10 mRNA CTD PMID:19647056 PMID:21404309 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of CXCL12 mRNA CTD PMID:21404309 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
JBrowse link
G Cxcl13 C-X-C motif chemokine ligand 13 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of CXCL13 mRNA CTD PMID:21404309 NCBI chr14:13,608,894...13,613,965
Ensembl chr14:13,608,902...13,613,933
JBrowse link
G Cxcl16 C-X-C motif chemokine ligand 16 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CXCL16 mRNA CTD PMID:19647056 NCBI chr10:55,166,721...55,171,316
Ensembl chr10:55,166,723...55,171,592
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions
increases expression
ISO AWD 12-281 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CXCL2 protein]; Cilomilast inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CXCL2 protein]; diflorasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CXCL2 protein]; ICAM1 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of CXCL2 protein]
Toluene 2,4-Diisocyanate results in increased expression of CXCL2 mRNA; Toluene 2,4-Diisocyanate results in increased expression of CXCL2 protein
CTD PMID:12956900 PMID:16963530 PMID:17014439 PMID:17980417 PMID:28826779 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CXCL1 mRNA CTD PMID:19647056 PMID:28826779 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 decreases expression
increases expression
ISO Toluene 2,4-Diisocyanate results in decreased expression of CXCL9 mRNA
Toluene 2,4-Diisocyanate results in increased expression of CXCL9 mRNA
CTD PMID:11379042 PMID:19647056 PMID:21404309 PMID:28826779 NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435
JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CXCR3 mRNA CTD PMID:21404309 NCBI chr  X:66,844,318...66,846,969
Ensembl chr  X:66,844,318...66,846,969
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of CXCR4 mRNA CTD PMID:11379042 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Cxcr6 C-X-C motif chemokine receptor 6 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of CXCR6 mRNA CTD PMID:21404309 NCBI chr 8:123,434,417...123,439,568
Ensembl chr 8:123,416,325...123,439,526
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 affects response to substance
increases expression
multiple interactions
ISO CYP1A1 gene polymorphism affects the susceptibility to Toluene 2,4-Diisocyanate
Toluene 2,4-Diisocyanate results in increased expression of CYP1A1 mRNA
Toluene 2,4-Diisocyanate results in increased expression of and results in decreased activity of CYP1A1 protein
CTD PMID:12415424 PMID:18447907 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases expression
increases expression
EXP Toluene 2,4-Diisocyanate results in decreased expression of CYP2B1 mRNA; Toluene 2,4-Diisocyanate results in decreased expression of CYP2B1 protein
Toluene 2,4-Diisocyanate results in increased expression of CYP2B1
CTD PMID:11043495 PMID:12415424 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of CYP2F2 mRNA CTD PMID:11379042 NCBI chr 1:82,416,108...82,429,897
Ensembl chr 1:82,416,130...82,429,896
JBrowse link
G Dact1 dishevelled-binding antagonist of beta-catenin 1 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of DACT1 mRNA CTD PMID:18242016 NCBI chr 6:89,790,676...89,818,254
Ensembl chr 6:89,790,644...89,817,906
JBrowse link
G Dbf4 DBF4 zinc finger increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of DBF4 mRNA CTD PMID:21404309 NCBI chr 4:25,676,570...25,701,152
Ensembl chr 4:25,676,634...25,701,066
JBrowse link
G Dnajb6 DnaJ heat shock protein family (Hsp40) member B6 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of DNAJB6 mRNA CTD PMID:11379042 NCBI chr 4:5,452,683...5,556,679
Ensembl chr 4:5,452,683...5,556,659
JBrowse link
G Dntt DNA nucleotidylexotransferase decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of DNTT mRNA CTD PMID:21404309 NCBI chr 1:239,856,391...239,888,283
Ensembl chr 1:239,856,391...239,888,282
JBrowse link
G Dpyd dihydropyrimidine dehydrogenase decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of DPYD mRNA CTD PMID:21404309 NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982
JBrowse link
G Dtymk deoxythymidylate kinase increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of DTYMK mRNA CTD PMID:21404309 NCBI chr 9:94,315,552...94,324,386
Ensembl chr 9:94,315,552...94,324,870
JBrowse link
G Dusp4 dual specificity phosphatase 4 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of DUSP4 mRNA CTD PMID:18242016 NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138
JBrowse link
G Dut deoxyuridine triphosphatase increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of DUT mRNA CTD PMID:18242016 PMID:21404309 NCBI chr 3:112,498,864...112,509,994
Ensembl chr 3:112,498,982...112,510,771
JBrowse link
G E2f1 E2F transcription factor 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of E2F1 mRNA CTD PMID:21404309 NCBI chr 3:143,064,535...143,075,362 JBrowse link
G E2f2 E2F transcription factor 2 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of E2F2 mRNA CTD PMID:21404309 NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO EGFR protein affects the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CCL5 protein]; EGFR protein affects the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein]; EGFR protein affects the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CXCL8 protein] CTD PMID:16908450 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 multiple interactions ISO 2',3'-dialdehyde ATP inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of ENPP2 protein]; 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of ENPP2 protein]; Acetylcysteine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of ENPP2 protein]; Adenosine Triphosphate promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of ENPP2 protein]; CAV1 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of ENPP2 protein]; CCL2 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased secretion of ENPP2 protein]; coomassie Brilliant Blue inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of ENPP2 protein]; KN 62 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of ENPP2 protein]; P2RX4 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of ENPP2 protein]; P2RX7 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of ENPP2 protein]; P2RX7 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of ENPP2 protein]; Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of ENPP2 protein; Toluene 2,4-Diisocyanate results in increased secretion of and results in increased expression of ENPP2 protein CTD PMID:26072274 PMID:29940203 NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827
JBrowse link
G Epor erythropoietin receptor decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of EPOR mRNA CTD PMID:21404309 NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257
JBrowse link
G Ercc6l ERCC excision repair 6 like, spindle assembly checkpoint helicase increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of ERCC6L mRNA CTD PMID:18242016 NCBI chr  X:67,245,414...67,261,222
Ensembl chr  X:67,245,414...67,280,756
JBrowse link
G Fabp1 fatty acid binding protein 1 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of FABP1 mRNA CTD PMID:18242016 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
JBrowse link
G Fcer2 Fc fragment of IgE receptor II decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of FCER2A mRNA CTD PMID:21404309 NCBI chr12:1,742,809...1,754,476
Ensembl chr12:1,742,815...1,754,476
JBrowse link
G Ffar2 free fatty acid receptor 2 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of FFAR2 mRNA CTD PMID:18242016 NCBI chr 1:86,071,860...86,075,049
Ensembl chr 1:86,072,184...86,075,033
JBrowse link
G Fus FUS RNA binding protein decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of FUS mRNA CTD PMID:11379042 NCBI chr 1:182,576,479...182,590,417
Ensembl chr 1:182,576,545...182,590,414
JBrowse link
G Grap2 GRB2-related adaptor protein 2 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of GRAP2 mRNA CTD PMID:21404309 NCBI chr 7:112,117,142...112,190,880
Ensembl chr 7:112,117,142...112,190,877
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases phosphorylation
ISO 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of GSK3B protein]; GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of GSK3B protein] CTD PMID:26089345 PMID:30517707 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases response to substance
decreases expression
ISO GSTM1 protein polymorphism results in increased susceptibility to Toluene 2,4-Diisocyanate
Toluene 2,4-Diisocyanate results in decreased expression of GSTM1 mRNA
CTD PMID:11927838 PMID:21404309 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of GSTM3 mRNA; Toluene 2,4-Diisocyanate results in decreased expression of GSTM5 mRNA CTD PMID:21404309 NCBI chr 2:195,531,627...195,534,562
Ensembl chr 2:195,531,495...195,534,553
JBrowse link
G Gsto2 glutathione S-transferase omega 2 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of GSTO2 mRNA CTD PMID:21404309 NCBI chr 1:246,731,314...246,757,592
Ensembl chr 1:246,732,089...246,753,866
JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects metabolic processing
affects response to substance
ISO GSTP1 gene polymorphism affects the metabolism of Toluene 2,4-Diisocyanate
GSTP1 gene polymorphism affects the susceptibility to Toluene 2,4-Diisocyanate
CTD PMID:20032816 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Gzma granzyme A increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of GZMA mRNA CTD PMID:18242016 NCBI chr 2:44,740,638...44,752,471
Ensembl chr 2:44,740,569...44,752,493
JBrowse link
G Gzmb granzyme B decreases expression
increases expression
ISO Toluene 2,4-Diisocyanate results in decreased expression of GZMB mRNA
Toluene 2,4-Diisocyanate results in increased expression of GZMB mRNA
CTD PMID:11379042 PMID:18652873 NCBI chr15:30,343,361...30,346,792 JBrowse link
G Hdc histidine decarboxylase multiple interactions
increases expression
increases activity
EXP Dexamethasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased activity of HDC protein]; Dexamethasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HDC mRNA]; sho-seiryu-to inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HDC mRNA] CTD PMID:15054596 PMID:18360087 PMID:19050374 NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HMGB1 protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HMGB1 protein] CTD PMID:25929181 PMID:28329851 NCBI chr12:5,973,062...5,978,565 JBrowse link
G Hnrnpll heterogeneous nuclear ribonucleoprotein L-like increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of HNRNPLL mRNA CTD PMID:21404309 NCBI chr 6:14,969,953...15,000,574
Ensembl chr 6:14,970,057...14,999,745
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions
increases expression
EXP Chlorpheniramine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]; Dexamethasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]; epinastine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]; Olopatadine Hydrochloride inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]; Quercetin inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]; sho-seiryu-to inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]; Toluene 2,4-Diisocyanate promotes the reaction [Pyrilamine binds to HRH1 protein]
Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA; Toluene 2,4-Diisocyanate results in increased expression of HRH1 protein
CTD PMID:15054595 PMID:15513549 PMID:18360087 PMID:19050374 PMID:19075512 More... NCBI chr 4:147,564,781...147,649,353
Ensembl chr 4:147,645,995...147,647,455
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of HSP90AB1 mRNA CTD PMID:11379042 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of HSPA4 mRNA CTD PMID:11379042 NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression
multiple interactions
ISO Toluene 2,4-Diisocyanate results in increased expression of ICAM1 protein
Toluene 2,4-Diisocyanate results in increased expression of ICAM1 mRNA; Toluene 2,4-Diisocyanate results in increased expression of ICAM1 protein
4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of ICAM1 mRNA]; BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of ICAM1 protein]; ICAM1 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of CXCL2 protein]; ICAM1 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IFNG protein]; ICAM1 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; ICAM1 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 protein]; ICAM1 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of TNF protein]; IL1A protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of ICAM1 mRNA]; IL1B protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of ICAM1 mRNA]; pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of ICAM1 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of ICAM1 protein]; rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of ICAM1 protein]
CTD PMID:11698162 PMID:12789230 PMID:16210060 PMID:17014439 PMID:17015710 More... NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Icos inducible T-cell co-stimulator increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of ICOS protein CTD PMID:27103660 NCBI chr 9:62,368,075...62,406,900
Ensembl chr 9:62,383,832...62,405,672
JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of IFI27 mRNA CTD PMID:18242016 NCBI chr 6:122,590,461...122,596,996
Ensembl chr 6:122,590,472...122,779,294
JBrowse link
G Ifi44l interferon-induced protein 44-like increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of IFI44L mRNA CTD PMID:18242016 NCBI chr 2:240,668,742...240,706,425
Ensembl chr 2:240,668,713...240,706,359
JBrowse link
G Ifnb1 interferon beta 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of IFNB1 mRNA CTD PMID:11379042 NCBI chr 5:103,020,969...103,021,523
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Ifng interferon gamma multiple interactions
increases secretion
increases expression
affects secretion
decreases expression
ISO CD4 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IFNG mRNA]; ICAM1 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IFNG protein]; TSLP protein affects the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IFNG protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IFNG protein]
Toluene 2,4-Diisocyanate results in increased expression of IFNG mRNA; Toluene 2,4-Diisocyanate results in increased expression of IFNG protein
Toluene 2,4-Diisocyanate affects the secretion of IFNG protein
Toluene 2,4-Diisocyanate results in decreased expression of IFNG mRNA; Toluene 2,4-Diisocyanate results in decreased expression of IFNG protein
CTD PMID:10637130 PMID:11243917 PMID:12356572 PMID:12884401 PMID:15588918 More... NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Ifngr2 interferon gamma receptor 2 increases expression
decreases expression
ISO Toluene 2,4-Diisocyanate results in increased expression of IFNGR2 mRNA
Toluene 2,4-Diisocyanate results in decreased expression of IFNGR2 mRNA
CTD PMID:19647056 PMID:21404309 NCBI chr11:30,779,733...30,798,005
Ensembl chr11:30,779,733...30,798,005
JBrowse link
G Il10 interleukin 10 increases expression
multiple interactions
decreases secretion
ISO Toluene 2,4-Diisocyanate results in increased expression of IL10 mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL10 protein
5-(5-(4-fluoro-2-hydroxyphenyl)furan-2-ylmethylene)thiazolidine-2,4-dione inhibits the reaction [Toluene 2,4-Diisocyanate results in decreased secretion of IL10 protein]; 5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione inhibits the reaction [Toluene 2,4-Diisocyanate results in decreased secretion of IL10 protein]; IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in decreased secretion of IL10 protein]; N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine inhibits the reaction [Toluene 2,4-Diisocyanate results in decreased secretion of IL10 protein]
CTD PMID:11243917 PMID:12884401 PMID:16940033 PMID:19422874 PMID:19428947 More... NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il11ra1 interleukin 11 receptor subunit alpha 1 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of IL11RA1 mRNA CTD PMID:21404309 NCBI chr 5:56,931,824...56,941,408
Ensembl chr 5:56,935,516...56,941,408
JBrowse link
G Il12b interleukin 12B increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of IL12B mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL12B protein CTD PMID:11379042 PMID:18652873 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il12rb1 interleukin 12 receptor subunit beta 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of IL12RB1 mRNA CTD PMID:18242016 PMID:21404309 NCBI chr16:18,620,228...18,633,207
Ensembl chr16:18,620,770...18,632,769
JBrowse link
G Il13 interleukin 13 multiple interactions
increases secretion
increases expression
ISO 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL13 protein]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]; AG 1879 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]; BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]; CD4 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 mRNA]; FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]; FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL13 protein]; GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL13 protein]; Methoxychlor promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]; Pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]; pyrazolanthrone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL13 protein]; Rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL13 protein]
Toluene 2,4-Diisocyanate results in increased expression of IL13 mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL13 protein
CTD PMID:11243917 PMID:15590890 PMID:16940033 PMID:17015710 PMID:17641053 More... NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il15 interleukin 15 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of IL15 mRNA CTD PMID:11243917 PMID:11379042 NCBI chr19:25,640,013...25,706,818
Ensembl chr19:25,640,251...25,706,820
JBrowse link
G Il17a interleukin 17A multiple interactions
increases secretion
decreases expression
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA]; BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A protein]; PTEN protein inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA]; PTEN protein inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A protein]; TSLP protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA]; TSLP protein affects the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL17A protein]; Wortmannin inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA]
Toluene 2,4-Diisocyanate results in decreased expression of IL17A protein
Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL17A protein
CTD PMID:17982072 PMID:28826779 PMID:31577921 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il18 interleukin 18 multiple interactions
increases expression
increases secretion
ISO 1-(2-((1-(4-amino-3-chlorophenyl)methanoyl)amino)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxylic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL18 protein]; 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL18 protein]; GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL18 protein]; IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL18 protein]; L 709049 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL18 protein]; MCC-950 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL18 protein]; N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL18 protein] CTD PMID:30517707 PMID:31070765 PMID:33711354 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il19 interleukin 19 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of IL19 mRNA CTD PMID:19647056 NCBI chr13:42,397,715...42,411,637
Ensembl chr13:42,399,138...42,405,473
JBrowse link
G Il1a interleukin 1 alpha multiple interactions
increases secretion
ISO IL1A protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of ICAM1 mRNA]; IL1A protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; IL1A protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of VCAM1 mRNA]
Toluene 2,4-Diisocyanate results in increased secretion of IL1A protein
CTD PMID:1699434 PMID:16210060 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion
increases expression
ISO [Tetradecanoylphorbol Acetate co-treated with Toluene 2,4-Diisocyanate] results in increased expression of and results in increased secretion of IL1B protein; IL1B protein affects the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CXCL8 protein]; P2RX7 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of IL1B protein]; Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of IL1B protein
Toluene 2,4-Diisocyanate results in increased secretion of IL1B protein
Toluene 2,4-Diisocyanate results in increased expression of IL1B mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL1B protein
1-(2-((1-(4-amino-3-chlorophenyl)methanoyl)amino)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxylic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL1B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL1B protein]; 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL1B mRNA]; 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL1B protein]; AWD 12-281 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL1B protein]; bisphenol A promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of IL1B protein]; Cilomilast inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL1B protein]; IL1B protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of ICAM1 mRNA]; IL1B protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; IL1B protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of VCAM1 mRNA]; L 709049 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL1B protein]; MCC-950 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL1B protein]; Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of IL1B protein
CTD PMID:1699434 PMID:11379042 PMID:12098602 PMID:12789230 PMID:14676436 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of IL1RL1 mRNA CTD PMID:11379042 NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256
JBrowse link
G Il2 interleukin 2 decreases expression
increases expression
ISO Toluene 2,4-Diisocyanate results in decreased expression of IL2 mRNA
Toluene 2,4-Diisocyanate results in increased expression of IL2 mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL2 protein
CTD PMID:11379042 PMID:18652873 PMID:22381623 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il24 interleukin 24 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of IL24 mRNA CTD PMID:19647056 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of IL2RA mRNA CTD PMID:21404309 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
JBrowse link
G Il2rb interleukin 2 receptor subunit beta increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of IL2RB mRNA CTD PMID:19647056 PMID:21404309 NCBI chr 7:110,033,341...110,048,054
Ensembl chr 7:110,033,341...110,048,054
JBrowse link
G Il3 interleukin 3 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of IL3 mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL3 protein CTD PMID:11379042 PMID:16271432 PMID:18652873 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066
JBrowse link
G Il33 interleukin 33 increases expression
multiple interactions
ISO Toluene 2,4-Diisocyanate results in increased expression of IL33 protein
4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL33 protein]; [4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol co-treated with Toluene 2,4-Diisocyanate] results in increased expression of IL33 protein; [diarylpropionitrile co-treated with Toluene 2,4-Diisocyanate] results in increased expression of IL33 protein; bisphenol A promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of IL33 protein]; diarylpropionitrile inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL33 protein]; Estradiol promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL33 protein]; Methoxychlor promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL33 protein]; Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of IL33 protein
CTD PMID:29846729 PMID:30017638 PMID:30445053 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
JBrowse link
G Il4 interleukin 4 multiple interactions
increases expression
increases secretion
affects secretion
ISO
EXP
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; 5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione promotes the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; [Toluene 2,4-Diisocyanate co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL4 protein; AG 1879 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; AWD 12-281 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; bisphenol A promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of IL4 protein]; CD4 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; Cilomilast inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; diflorasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; Estradiol promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; ICAM1 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; IL1A protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; IL1B protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; Methoxychlor promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; Pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; pyrazolanthrone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; Rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of IL4 protein; TSLP protein affects the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]
Chlorpheniramine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; epinastine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; Olopatadine Hydrochloride inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; Quercetin inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; sho-seiryu-to inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]
Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL4 protein
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]
Toluene 2,4-Diisocyanate affects the secretion of IL4 protein
CTD PMID:10637130 PMID:11243917 PMID:11467998 PMID:11708898 PMID:11758997 More... NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il4r interleukin 4 receptor increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of IL4RA mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL4RA protein CTD PMID:19647056 PMID:22381623 NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980
JBrowse link
G Il5 interleukin 5 multiple interactions
increases secretion
increases expression
ISO
EXP
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL5 protein]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 protein]; AG 1879 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 protein]; BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 protein]; CD4 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 mRNA]; epigallocatechin gallate inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 protein]; FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 protein]; FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL5 protein]; GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL5 protein]; IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL5 protein]; ICAM1 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 protein]; N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL5 protein]; Pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 protein]; pyrazolanthrone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL5 protein]; Rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL5 protein]
sho-seiryu-to inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 mRNA]
Toluene 2,4-Diisocyanate results in increased expression of IL5 mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL5 protein
CTD PMID:15590890 PMID:16271432 PMID:16516891 PMID:17014439 PMID:17015710 More... NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion
increases expression
ISO
EXP
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL6 protein]; 5-(5-(4-fluoro-2-hydroxyphenyl)furan-2-ylmethylene)thiazolidine-2,4-dione promotes the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL6 protein]; 5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione promotes the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL6 protein]; AWD 12-281 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL6 protein]; Cilomilast inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL6 protein]; diflorasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL6 protein]; GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL6 protein]; IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL6 protein]; N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL6 protein]
[Tetradecanoylphorbol Acetate co-treated with Toluene 2,4-Diisocyanate] results in increased expression of and results in increased secretion of IL6 protein
Toluene 2,4-Diisocyanate results in increased expression of IL6 mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL6 protein
CTD PMID:1699434 PMID:11758997 PMID:12956900 PMID:18652873 PMID:19647056 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Il7 interleukin 7 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of IL7 mRNA CTD PMID:18242016 PMID:21404309 NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075
JBrowse link
G Il7r interleukin 7 receptor decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of IL7R mRNA CTD PMID:21404309 NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757
JBrowse link
G Il9 interleukin 9 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of IL9 mRNA CTD PMID:11243917 NCBI chr17:8,111,772...8,114,895
Ensembl chr17:8,111,772...8,114,895
JBrowse link
G Inhba inhibin subunit beta A increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of INHBA mRNA CTD PMID:19647056 NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of ISG15 mRNA CTD PMID:11379042 NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435
JBrowse link
G Itgae integrin subunit alpha E increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of ITGAE protein CTD PMID:27103660 NCBI chr10:57,704,813...57,764,093
Ensembl chr10:57,591,753...57,764,093
JBrowse link
G Kitlg KIT ligand decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of KITL mRNA CTD PMID:21404309 NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214
JBrowse link
G Krt14 keratin 14 multiple interactions ISO [Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of KRT14 mRNA CTD PMID:15478392 NCBI chr10:85,137,932...85,141,990
Ensembl chr10:85,066,802...85,171,799
JBrowse link
G Krt19 keratin 19 multiple interactions ISO [Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of KRT19 mRNA CTD PMID:15478392 NCBI chr10:85,075,835...85,080,552 JBrowse link
G Lig1 DNA ligase 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of LIG1 mRNA CTD PMID:21404309 NCBI chr 1:74,165,688...74,204,400
Ensembl chr 1:74,165,842...74,204,413
JBrowse link
G Lta lymphotoxin alpha multiple interactions
increases expression
ISO TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of LTA mRNA] CTD PMID:12356572 NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859
JBrowse link
G Ltb lymphotoxin beta multiple interactions
increases expression
ISO TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of LTB mRNA] CTD PMID:11467998 PMID:12356572 PMID:19647056 NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of MAP3K7 mRNA CTD PMID:11379042 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO [Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased phosphorylation of MAPK1 protein; RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased phosphorylation of MAPK1 protein]
Toluene 2,4-Diisocyanate results in increased phosphorylation of MAPK1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of MAPK1 protein]
CTD PMID:16908450 PMID:26089345 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO [Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased phosphorylation of MAPK3 protein; RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased phosphorylation of MAPK3 protein]
Toluene 2,4-Diisocyanate results in increased phosphorylation of MAPK3 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of MAPK3 protein]
CTD PMID:16908450 PMID:26089345 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
ISO Toluene 2,4-Diisocyanate results in increased phosphorylation of MAPK8 protein
pyrazolanthrone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of MAPK8 protein]
CTD PMID:33075463 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation
ISO pyrazolanthrone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of MAPK9 protein] CTD PMID:33075463 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mcm2 minichromosome maintenance complex component 2 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of MCM2 mRNA CTD PMID:21404309 NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of MCM3 mRNA CTD PMID:21404309 NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of MCM4 mRNA CTD PMID:21404309 NCBI chr11:85,258,443...85,272,144
Ensembl chr11:85,258,443...85,272,144
JBrowse link
G Mcm5 minichromosome maintenance complex component 5 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of MCM5 mRNA CTD PMID:21404309 NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389
JBrowse link
G Mcm6 minichromosome maintenance complex component 6 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of MCM6 mRNA CTD PMID:21404309 NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960
JBrowse link
G Mcm7 minichromosome maintenance complex component 7 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of MCM7 mRNA CTD PMID:21404309 NCBI chr12:17,042,207...17,049,470
Ensembl chr12:17,042,212...17,050,063
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of MGST1 mRNA CTD PMID:21404309 NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of MGST2 mRNA CTD PMID:21404309 NCBI chr 2:135,679,524...135,715,828
Ensembl chr 2:135,693,557...135,715,828
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
increases expression
increases activity
multiple interactions
ISO Toluene 2,4-Diisocyanate results in decreased expression of MMP9 protein
Toluene 2,4-Diisocyanate results in increased expression of MMP9 mRNA; Toluene 2,4-Diisocyanate results in increased expression of MMP9 protein
Toluene 2,4-Diisocyanate results in increased activity of MMP9 protein
4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of MMP9 mRNA]; 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of MMP9 protein]; Doxycycline inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of MMP9 mRNA]; Doxycycline inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of MMP9 protein]; epigallocatechin gallate inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased activity of MMP9 protein]; epigallocatechin gallate inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of MMP9 mRNA]; Toluene 2,4-Diisocyanate results in increased expression of and results in increased activity of MMP9 protein
CTD PMID:11742282 PMID:12534559 PMID:12789230 PMID:14987308 PMID:15131573 More... NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mtcp1 mature T-cell proliferation 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of MTCP1 mRNA CTD PMID:11379042 NCBI chr18:126,189...130,123 JBrowse link
G Mx2 MX dynamin like GTPase 2 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of MX2 mRNA CTD PMID:19647056 NCBI chr11:36,905,698...36,936,308
Ensembl chr11:36,906,111...36,930,342
JBrowse link
G Nat1 N-acetyltransferase 1 affects response to substance
increases response to substance
ISO NAT1 gene polymorphism affects the susceptibility to Toluene 2,4-Diisocyanate
NAT1 protein polymorphism results in increased susceptibility to Toluene 2,4-Diisocyanate
CTD PMID:11927838 PMID:18447907 NCBI chr16:22,218,217...22,238,516 JBrowse link
G Nat2 N-acetyltransferase 2 increases response to substance ISO NAT2 protein polymorphism results in increased susceptibility to Toluene 2,4-Diisocyanate CTD PMID:11927838 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
JBrowse link
G Ndp norrin cystine knot growth factor NDP increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of NDP mRNA CTD PMID:11379042 NCBI chr  X:5,796,487...5,820,934
Ensembl chr  X:5,796,487...5,820,934
JBrowse link
G Ngf nerve growth factor multiple interactions
increases expression
EXP NGF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of TAC1 protein]
Toluene 2,4-Diisocyanate results in increased expression of NGF protein
CTD PMID:14672914 PMID:16020193 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO MCC-950 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased activity of NLRP3 protein]; Toluene 2,4-Diisocyanate results in increased expression of and results in increased activity of NLRP3 protein CTD PMID:31070765 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of NOS2 protein CTD PMID:12974195 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of NOS3 protein CTD PMID:12974195 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nrp1 neuropilin 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of NRP1 protein CTD PMID:27103660 NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633
JBrowse link
G Odc1 ornithine decarboxylase 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of ODC1 mRNA CTD PMID:21404309 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
JBrowse link
G Orc1 origin recognition complex, subunit 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of ORC1 mRNA CTD PMID:21404309 NCBI chr 5:123,324,273...123,348,375
Ensembl chr 5:123,324,315...123,348,375
JBrowse link
G Orc6 origin recognition complex, subunit 6 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of ORC6 mRNA CTD PMID:21404309 NCBI chr19:21,757,867...21,765,638
Ensembl chr19:21,757,866...21,765,662
JBrowse link
G Osm oncostatin M increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of OSM mRNA CTD PMID:19647056 NCBI chr14:79,103,638...79,108,500
Ensembl chr14:79,104,344...79,108,313
JBrowse link
G P2rx4 purinergic receptor P2X 4 multiple interactions ISO P2RX4 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of ENPP2 protein] CTD PMID:26072274 NCBI chr12:33,844,609...33,862,265
Ensembl chr12:33,844,396...33,862,253
JBrowse link
G P2rx7 purinergic receptor P2X 7 multiple interactions
affects response to substance
ISO P2RX7 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of ENPP2 protein]; P2RX7 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of IL1B protein]; P2RX7 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of ENPP2 protein]
P2RX7 gene SNP affects the susceptibility to Toluene 2,4-Diisocyanate
CTD PMID:26072274 PMID:29940203 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of PCNA mRNA CTD PMID:21404309 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pf4 platelet factor 4 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of PF4 mRNA CTD PMID:19647056 NCBI chr14:17,298,438...17,299,148
Ensembl chr14:17,298,308...17,299,365
JBrowse link
G Phf11 PHD finger protein 11 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of PHF11 mRNA CTD PMID:19647056 NCBI chr15:33,390,290...33,414,647
Ensembl chr15:33,390,292...33,413,009
JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta increases expression
multiple interactions
ISO Toluene 2,4-Diisocyanate results in increased expression of PIK3CD protein
IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of PIK3CD protein]; N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of PIK3CD protein]
CTD PMID:33711354 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma increases expression
multiple interactions
ISO Toluene 2,4-Diisocyanate results in increased expression of PIK3CG protein
IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of PIK3CG protein]; N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of PIK3CG protein]
CTD PMID:33711354 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043
JBrowse link
G Pkmyt1 protein kinase, membrane associated tyrosine/threonine 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of PKMYT1 mRNA CTD PMID:21404309 NCBI chr10:12,748,221...12,758,995
Ensembl chr10:12,748,237...12,758,995
JBrowse link
G Plk1 polo-like kinase 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of PLK1 mRNA CTD PMID:21404309 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400
JBrowse link
G Pola1 DNA polymerase alpha 1, catalytic subunit increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of POLA1 mRNA CTD PMID:21404309 NCBI chr  X:58,034,617...58,348,612
Ensembl chr  X:58,034,619...58,348,536
JBrowse link
G Pola2 DNA polymerase alpha 2, accessory subunit increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of POLA2 mRNA CTD PMID:21404309 NCBI chr 1:203,227,183...203,251,350
Ensembl chr 1:203,203,388...203,251,348
JBrowse link
G Pold1 DNA polymerase delta 1, catalytic subunit increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of POLD1 mRNA CTD PMID:21404309 NCBI chr 1:95,025,462...95,041,559
Ensembl chr 1:95,025,499...95,036,465
JBrowse link
G Pold3 DNA polymerase delta 3, accessory subunit increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of POLD3 mRNA CTD PMID:21404309 NCBI chr 1:154,417,893...154,456,687
Ensembl chr 1:154,418,084...154,456,665
JBrowse link
G Pole DNA polymerase epsilon, catalytic subunit increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of POLE mRNA CTD PMID:21404309 NCBI chr12:46,345,420...46,393,984
Ensembl chr12:46,345,420...46,393,939
JBrowse link
G Polr1b RNA polymerase I subunit B increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of POLR1B mRNA CTD PMID:21404309 NCBI chr 3:116,333,910...116,358,385
Ensembl chr 3:116,333,889...116,358,379
JBrowse link
G Ppa1 inorganic pyrophosphatase 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of PPA1 mRNA CTD PMID:18242016 NCBI chr20:29,590,733...29,617,711
Ensembl chr20:29,590,707...29,619,215
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases localization
ISO pioglitazone promotes the reaction [Toluene 2,4-Diisocyanate results in increased localization of PPARG protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL11 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL5 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of ICAM1 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of TGFB1 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of VCAM1 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased localization of RELA protein]; rosiglitazone promotes the reaction [Toluene 2,4-Diisocyanate results in increased localization of PPARG protein] CTD PMID:17015710 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppbp pro-platelet basic protein increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of PPBP mRNA CTD PMID:19647056 NCBI chr14:17,302,326...17,303,130
Ensembl chr14:17,302,326...17,303,130
JBrowse link
G Ppp2r3a protein phosphatase 2, regulatory subunit B'', alpha increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of PPP2R3A mRNA CTD PMID:11379042 NCBI chr 8:101,703,512...101,841,530
Ensembl chr 8:101,704,778...101,841,502
JBrowse link
G Prim1 DNA primase subunit 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of PRIM1 mRNA CTD PMID:21404309 NCBI chr 7:446,342...462,526
Ensembl chr 7:431,805...462,526
JBrowse link
G Psme4 proteasome activator subunit 4 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of PSME4 mRNA CTD PMID:21404309 NCBI chr14:104,505,716...104,609,410
Ensembl chr14:104,505,716...104,609,408
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO PTEN protein inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA]; PTEN protein inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A protein]; PTEN protein inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of RELA protein]; Toluene 2,4-Diisocyanate results in decreased expression of and results in decreased activity of PTEN protein CTD PMID:17982072 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of PTTG1 mRNA CTD PMID:21404309 NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837
JBrowse link
G Rbl1 RB transcriptional corepressor like 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of RBL1 mRNA CTD PMID:11379042 NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330
JBrowse link
G Rcc1 regulator of chromosome condensation 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of RCC1 mRNA CTD PMID:18242016 NCBI chr 5:144,526,025...144,544,445
Ensembl chr 5:144,526,025...144,544,577
JBrowse link
G Rcn1 reticulocalbin 1 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of RCN1 mRNA CTD PMID:11379042 NCBI chr 3:91,841,052...91,855,295
Ensembl chr 3:91,841,052...91,855,295
JBrowse link
G Recql4 RecQ like helicase 4 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of RECQL4 mRNA CTD PMID:18242016 NCBI chr 7:108,423,453...108,430,790
Ensembl chr 7:108,423,455...108,430,619
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression
increases localization
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of RELA protein]; Pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased localization of RELA protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased localization of RELA protein]; PTEN protein inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of RELA protein]; Rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased localization of RELA protein]; Wortmannin inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of RELA protein] CTD PMID:17015710 PMID:17982072 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rfc3 replication factor C subunit 3 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of RFC3 mRNA CTD PMID:21404309 NCBI chr12:1,000,987...1,011,778
Ensembl chr12:1,000,994...1,011,778
JBrowse link
G Rfc4 replication factor C subunit 4 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of RFC4 mRNA CTD PMID:21404309 NCBI chr11:77,749,642...77,764,123
Ensembl chr11:77,749,638...77,764,122
JBrowse link
G Rfc5 replication factor C subunit 5 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of RFC5 mRNA CTD PMID:21404309 NCBI chr12:39,207,484...39,217,041
Ensembl chr12:39,207,484...39,217,312
JBrowse link
G Rhoa ras homolog family member A decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of RHOA mRNA CTD PMID:11379042 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Rnase2 ribonuclease A family member 2 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of RNASE2A mRNA CTD PMID:18242016 NCBI chr15:24,449,618...24,450,427
Ensembl chr15:24,449,611...24,450,479
JBrowse link
G Rnaseh2b ribonuclease H2, subunit B increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of RNASEH2B mRNA CTD PMID:21404309 NCBI chr15:36,541,200...36,592,016
Ensembl chr15:36,541,218...36,584,118
JBrowse link
G Rorc RAR-related orphan receptor C increases expression
multiple interactions
ISO Toluene 2,4-Diisocyanate results in increased expression of RORC mRNA alternative form
TSLP protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of RORC mRNA alternative form]
CTD PMID:31577921 NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907
JBrowse link
G Rrm1 ribonucleotide reductase catalytic subunit M1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of RRM1 mRNA CTD PMID:21404309 NCBI chr 1:156,823,960...156,848,262
Ensembl chr 1:156,823,960...156,848,261
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of RRM2 mRNA CTD PMID:21404309 NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773
JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of RRM2B mRNA CTD PMID:21404309 NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633
JBrowse link
G RT1-Ba RT1 class II, locus Ba decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of H2-AA mRNA CTD PMID:21404309 NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744
JBrowse link
G RT1-Bb RT1 class II, locus Bb affects response to substance ISO HLA-DQB1 gene polymorphism affects the susceptibility to Toluene 2,4-Diisocyanate CTD PMID:18447907 NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
JBrowse link
G Rtp4 receptor (chemosensory) transporter protein 4 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of RTP4 mRNA CTD PMID:18242016 PMID:19647056 NCBI chr11:77,237,341...77,249,194
Ensembl chr11:77,238,216...77,335,437
JBrowse link
G Sftpd surfactant protein D increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of SFTPD mRNA CTD PMID:11379042 NCBI chr16:17,046,491...17,058,968
Ensembl chr16:17,046,483...17,059,927
JBrowse link
G Skp2 S-phase kinase associated protein 2 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of SKP2 mRNA CTD PMID:21404309 NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338
JBrowse link
G Smad1 SMAD family member 1 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of SMAD1 mRNA CTD PMID:11379042 NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651
JBrowse link
G Sqle squalene epoxidase increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of SQLE mRNA CTD PMID:18242016 NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase increases phosphorylation
multiple interactions
ISO Toluene 2,4-Diisocyanate analog results in increased phosphorylation of SRC protein
Toluene 2,4-Diisocyanate results in increased phosphorylation of SRC protein
AG 1879 inhibits the reaction [Toluene 2,4-Diisocyanate analog results in increased phosphorylation of SRC protein]; FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate analog results in increased phosphorylation of SRC protein]
FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of SRC protein]
CTD PMID:30261222 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Srsf7 serine and arginine rich splicing factor 7 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of SRSF7 mRNA CTD PMID:11379042 NCBI chr 6:14,811,775...14,818,968
Ensembl chr 6:14,811,808...14,818,965
JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions ISO Toluene 2,4-Diisocyanate results in increased expression of and results in increased phosphorylation of STAT5A protein; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased phosphorylation of STAT5A protein] CTD PMID:28329851 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866
JBrowse link
G Stat5b signal transducer and activator of transcription 5B multiple interactions ISO Toluene 2,4-Diisocyanate results in increased expression of and results in increased phosphorylation of STAT5B protein; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased phosphorylation of STAT5B protein] CTD PMID:28329851 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 affects response to substance ISO SULT1A1 gene polymorphism affects the susceptibility to Toluene 2,4-Diisocyanate CTD PMID:18447907 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions
increases expression
EXP [Toluene 2,4-Diisocyanate co-treated with 2,6-diisocyanatotoluene] results in increased expression of TAC1 mRNA; [Toluene 2,4-Diisocyanate co-treated with 2,6-diisocyanatotoluene] results in increased expression of TAC1 protein; NGF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of TAC1 protein]; staurosporine aglycone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of TAC1 protein] CTD PMID:10673198 PMID:14672914 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Tfdp1 transcription factor Dp-1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of TFDP1 mRNA CTD PMID:18242016 PMID:21404309 NCBI chr16:76,162,040...76,200,871
Ensembl chr16:76,162,043...76,200,817
JBrowse link
G Tfec transcription factor EC increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of TFEC mRNA CTD PMID:19647056 NCBI chr 4:45,106,129...45,180,236
Ensembl chr 4:45,107,641...45,180,236
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression
ISO BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of TGFB1 protein]; pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of TGFB1 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of TGFB1 protein]; rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of TGFB1 protein] CTD PMID:17015710 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of TGFBR2 mRNA CTD PMID:21404309 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions
increases expression
ISO Toluene 2,4-Diisocyanate results in increased expression of and results in increased activity of TIMP1 protein
Toluene 2,4-Diisocyanate results in increased expression of TIMP1 mRNA; Toluene 2,4-Diisocyanate results in increased expression of TIMP1 protein
CTD PMID:12534559 PMID:14987308 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tk1 thymidine kinase 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of TK1 mRNA CTD PMID:21404309 NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of TNF mRNA]; 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of TNF protein]; bisphenol A promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of TNF protein]; epigallocatechin gallate inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of TNF protein]; ICAM1 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of TNF protein]; TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL5 mRNA]; TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of LTA mRNA]; TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of LTB mRNA]; TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of TNF mRNA]; TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of XCL1 mRNA]; Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of TNF protein
[Tetradecanoylphorbol Acetate co-treated with Toluene 2,4-Diisocyanate] results in increased expression of and results in increased secretion of TNF protein
Toluene 2,4-Diisocyanate results in increased expression of TNF mRNA; Toluene 2,4-Diisocyanate results in increased expression of TNF protein
CTD PMID:11467998 PMID:12356572 PMID:12789230 PMID:16516891 PMID:17014439 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf12a TNF receptor superfamily member 12A increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of TNFRSF12A mRNA CTD PMID:19647056 NCBI chr10:12,707,077...12,709,071
Ensembl chr10:12,689,890...12,709,045
JBrowse link
G Tnfrsf19 TNF receptor superfamily member 19 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of TNFRSF19 mRNA CTD PMID:21404309 NCBI chr15:35,092,206...35,158,472
Ensembl chr15:35,092,206...35,180,795
JBrowse link
G Tnfrsf4 TNF receptor superfamily member 4 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of TNFRSF4 mRNA CTD PMID:21404309 NCBI chr 5:166,606,909...166,609,599
Ensembl chr 5:166,606,909...166,609,599
JBrowse link
G Tnfsf13 TNF superfamily member 13 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of TNFSF13 mRNA CTD PMID:21404309 NCBI chr10:54,400,054...54,403,723
Ensembl chr10:54,400,065...54,403,042
JBrowse link
G Tnfsf13b TNF superfamily member 13b decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of TNFSF13B mRNA CTD PMID:21404309 NCBI chr16:79,462,406...79,492,888
Ensembl chr16:79,462,402...79,492,693
JBrowse link
G Tnfsf14 TNF superfamily member 14 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of TNFSF14 mRNA CTD PMID:19647056 NCBI chr 9:2,069,075...2,073,128
Ensembl chr 9:2,069,104...2,073,216
JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 increases expression
multiple interactions
ISO Toluene 2,4-Diisocyanate results in increased expression of TRPV4 protein
GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of TRPV4 protein]
CTD PMID:30517707 NCBI chr12:41,938,533...41,977,517
Ensembl chr12:41,938,560...41,977,517
JBrowse link
G Tslp thymic stromal lymphopoietin increases expression
increases secretion
multiple interactions
ISO Toluene 2,4-Diisocyanate results in increased expression of TSLP mRNA; Toluene 2,4-Diisocyanate results in increased expression of TSLP protein
Toluene 2,4-Diisocyanate results in increased secretion of TSLP protein
bisphenol A promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of TSLP protein]; Estradiol promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of TSLP protein]; Methoxychlor promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of TSLP protein]; Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of TSLP protein; TSLP protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA]; TSLP protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of RORC mRNA alternative form]; TSLP protein affects the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IFNG protein]; TSLP protein affects the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL17A protein]; TSLP protein affects the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of AGER protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased phosphorylation of STAT5A protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased phosphorylation of STAT5B protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HMGB1 protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of TSLP protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IFNG protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL13 protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL5 protein]
CTD PMID:19647056 PMID:28329851 PMID:29846729 PMID:30017638 PMID:31577921 NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548
JBrowse link
G Txn1 thioredoxin 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of TXN1 mRNA CTD PMID:19647056 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
G Tyms thymidylate synthetase increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of TYMS mRNA CTD PMID:21404309 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
JBrowse link
G Uck2 uridine-cytidine kinase 2 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of UCK2 mRNA CTD PMID:21404309 NCBI chr13:79,380,807...79,438,352
Ensembl chr13:79,383,846...79,438,352
JBrowse link
G Upb1 beta-ureidopropionase 1 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of UPB1 mRNA CTD PMID:21404309 NCBI chr20:13,217,252...13,243,590
Ensembl chr20:13,217,258...13,243,590
JBrowse link
G Usp18 ubiquitin specific peptidase 18 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of USP18 mRNA CTD PMID:19647056 NCBI chr 4:154,471,634...154,499,154
Ensembl chr 4:154,471,592...154,499,144
JBrowse link
G Usp8 ubiquitin specific peptidase 8 decreases expression ISO Toluene 2,4-Diisocyanate results in decreased expression of USP8 mRNA CTD PMID:11379042 NCBI chr 3:113,962,136...114,009,683
Ensembl chr 3:113,962,164...114,009,666
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
increases expression
ISO
EXP
4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of VCAM1 mRNA]; BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of VCAM1 protein]; IL1A protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of VCAM1 mRNA]; IL1B protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of VCAM1 mRNA]; Pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of VCAM1 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of VCAM1 protein]; Rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of VCAM1 protein]
Toluene 2,4-Diisocyanate results in increased expression of VCAM1 mRNA; Toluene 2,4-Diisocyanate results in increased expression of VCAM1 protein
CTD PMID:12789230 PMID:15823807 PMID:16210060 PMID:17015710 PMID:17641053 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of VEGFA mRNA alternative form
Toluene 2,4-Diisocyanate results in increased expression of VEGFA protein
CTD PMID:11907124 PMID:18250044 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Xcl1 X-C motif chemokine ligand 1 multiple interactions
increases expression
ISO TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of XCL1 mRNA] CTD PMID:11467998 PMID:12356572 NCBI chr13:77,248,865...77,252,308
Ensembl chr13:77,248,717...77,252,329
JBrowse link
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of YWHAQ mRNA CTD PMID:11379042 NCBI chr 6:40,935,714...40,966,240
Ensembl chr 6:40,935,949...40,966,273
JBrowse link
G Zbp1 Z-DNA binding protein 1 increases expression ISO Toluene 2,4-Diisocyanate results in increased expression of ZBP1 mRNA CTD PMID:18242016 PMID:19647056 NCBI chr 3:161,993,351...162,009,297
Ensembl chr 3:161,993,351...162,003,870
JBrowse link
toluene 2,6-diisocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO 2,6-diisocyanatotoluene binds to ALB protein CTD PMID:9124697 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 increases expression
multiple interactions
ISO 2,6-diisocyanatotoluene results in increased expression of ENPP2 mRNA; 2,6-diisocyanatotoluene results in increased expression of ENPP2 protein
KN 62 inhibits the reaction [2,6-diisocyanatotoluene results in increased expression of ENPP2 mRNA]
CTD PMID:22952646 NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP [Toluene 2,4-Diisocyanate co-treated with 2,6-diisocyanatotoluene] results in increased expression of TAC1 mRNA; [Toluene 2,4-Diisocyanate co-treated with 2,6-diisocyanatotoluene] results in increased expression of TAC1 protein CTD PMID:10673198 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    role 19773
      chemical role 19341
        donor 18654
          Bronsted acid 18538
            hydracid 6758
              isocyanic acid 344
                isocyanates + 344
                isocyanato group 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      p-block molecular entity 19720
                        carbon group molecular entity 19643
                          organic molecular entity 19633
                            one-carbon compound 17667
                              isocyanic acid 344
                                isocyanates + 344
                                isocyanato group 0
paths to the root