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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:L-mimosine
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Accession:CHEBI:29063 term browser browse the term
Definition:An L-alpha-amino acid that is propionic acid substituted by an amino group at position 2 and a 3-hydroxy-4-oxopyridin-1(4H)-yl group at position 3 (the 2S-stereoisomer). It a non-protein plant amino acid isolated from Mimosa pudica.
Synonyms:exact_synonym: (2S)-2-amino-3-(3-hydroxy-4-oxopyridin-1(4H)-yl)propanoic acid
 related_synonym: (S)-2-amino-3-(3-hydroxy-4-oxo-4H-pyridin-1-yl)propanoate;   Formula=C8H10N2O4;   InChI=1S/C8H10N2O4/c9-5(8(13)14)3-10-2-1-6(11)7(12)4-10/h1-2,4-5,12H,3,9H2,(H,13,14)/t5-/m0/s1;   InChIKey=WZNJWVWKTVETCG-YFKPBYRVSA-N;   SMILES=C1=C(C(C=CN1C[C@@H](C(O)=O)N)=O)O
 alt_id: CHEBI:11029;   CHEBI:18732;   CHEBI:375
 xref: CAS:500-44-7;   Drug_Central:1811;   HMDB:HMDB0015188;   KEGG:C04771;   KNApSAcK:C00001383
 xref_mesh: MESH:D008898
 xref: PDBeChem:MMS;   PMID:12797899;   PMID:15938198;   PMID:28661582;   Reaxys:86165;   Wikipedia:Mimosine
 cyclic_relationship: is_conjugate_acid_of CHEBI:58604;   is_tautomer_of CHEBI:77689


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L-mimosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arnt aryl hydrocarbon receptor nuclear translocator increases activity EXP Mimosine results in increased activity of ARNT protein CTD PMID:10559391 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
JBrowse link
G Atf1 activating transcription factor 1 increases activity EXP Mimosine results in increased activity of ATF1 protein CTD PMID:10559391 NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670
JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression ISO Mimosine affects the expression of BCL2 protein CTD PMID:18058236 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions ISO Mimosine results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:18058236 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Mimosine results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:18058236 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [Mimosine results in decreased activity of TNF protein] CTD PMID:15550384 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Mimosine results in decreased expression of CCND1 CTD PMID:10530763 PMID:10995875 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Mimosine results in increased expression of CDKN1A CTD PMID:10530763 PMID:10995875 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Mimosine results in increased expression of CDKN1B CTD PMID:10530763 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases activity EXP Mimosine results in increased activity of CREB1 protein CTD PMID:10559391 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Ece1 endothelin converting enzyme 1 increases expression EXP
ISO
Mimosine results in increased expression of ECE1 mRNA; Mimosine results in increased expression of ECE1 protein CTD PMID:25469848 NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371
JBrowse link
G Edn1 endothelin 1 increases expression ISO
EXP
Mimosine results in increased expression of EDN1 mRNA; Mimosine results in increased expression of EDN1 protein CTD PMID:25469848 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases activity
increases expression
EXP
ISO
Mimosine results in increased activity of HIF1A protein
Mimosine results in increased expression of HIF1A protein
CTD PMID:10559391 PMID:24349381 PMID:25469848 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor decreases expression EXP
ISO
Mimosine results in decreased expression of LHCGR mRNA CTD PMID:19293332 NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521
JBrowse link
G Nmbr neuromedin B receptor increases expression ISO Mimosine results in increased expression of NMBR protein CTD PMID:24349381 NCBI chr 1:9,115,033...9,146,081
Ensembl chr 1:9,134,889...9,145,462
JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression ISO
EXP
Mimosine results in increased expression of SLC2A1 mRNA CTD PMID:25469848 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation EXP Mimosine results in increased phosphorylation of STAT3 protein CTD PMID:25469848 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases activity
ISO
EXP
Acetylcysteine inhibits the reaction [Mimosine results in decreased activity of TNF protein]; ferrous sulfate inhibits the reaction [Mimosine results in decreased activity of TNF protein]
Acetylcysteine inhibits the reaction [Mimosine results in decreased activity of TNF protein]; CAT protein inhibits the reaction [Mimosine results in decreased activity of TNF protein]
CTD PMID:15550384 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions
increases cleavage
ISO Acetylcysteine inhibits the reaction [Mimosine results in increased cleavage of TNFRSF1A protein] CTD PMID:15550384 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      application 19481
        pharmaceutical 19329
          drug 19329
            antifungal drug 5167
              propionic acid 3687
                L-mimosine 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        monocarboxylic acid 17636
                                          fatty acid 16008
                                            saturated fatty acid 15984
                                              propionic acid 3687
                                                L-mimosine 19
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