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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:L-mimosine
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Accession:CHEBI:29063 term browser browse the term
Definition:An L-alpha-amino acid that is propionic acid substituted by an amino group at position 2 and a 3-hydroxy-4-oxopyridin-1(4H)-yl group at position 3 (the 2S-stereoisomer). It a non-protein plant amino acid isolated from Mimosa pudica.
Synonyms:exact_synonym: (2S)-2-amino-3-(3-hydroxy-4-oxopyridin-1(4H)-yl)propanoic acid
 related_synonym: (S)-2-amino-3-(3-hydroxy-4-oxo-4H-pyridin-1-yl)propanoate;   Formula=C8H10N2O4;   InChI=1S/C8H10N2O4/c9-5(8(13)14)3-10-2-1-6(11)7(12)4-10/h1-2,4-5,12H,3,9H2,(H,13,14)/t5-/m0/s1;   InChIKey=WZNJWVWKTVETCG-YFKPBYRVSA-N;   SMILES=C1=C(C(C=CN1C[C@@H](C(O)=O)N)=O)O
 alt_id: CHEBI:11029;   CHEBI:18732;   CHEBI:375
 xref: CAS:500-44-7;   Drug_Central:1811;   HMDB:HMDB0015188;   KEGG:C04771;   KNApSAcK:C00001383
 xref_mesh: MESH:D008898
 xref: PDBeChem:MMS;   PMID:12797899;   PMID:15938198;   PMID:28661582;   Reaxys:86165;   Wikipedia:Mimosine
 cyclic_relationship: is_conjugate_acid_of CHEBI:58604;   is_tautomer_of CHEBI:77689


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L-mimosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arnt aryl hydrocarbon receptor nuclear translocator increases activity EXP Mimosine results in increased activity of ARNT protein CTD PMID:10559391 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Atf1 activating transcription factor 1 increases activity EXP Mimosine results in increased activity of ATF1 protein CTD PMID:10559391 NCBI chr 7:141,882,261...141,924,790
Ensembl chr 7:141,882,251...141,924,788
JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression ISO Mimosine affects the expression of BCL2 protein CTD PMID:18058236 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Mimosine results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:18058236 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Mimosine results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:18058236 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [Mimosine results in decreased activity of TNF protein] CTD PMID:15550384 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Mimosine results in decreased expression of CCND1 CTD PMID:10530763, PMID:10995875 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Mimosine results in increased expression of CDKN1A CTD PMID:10530763, PMID:10995875 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Mimosine results in increased expression of CDKN1B CTD PMID:10530763 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases activity EXP Mimosine results in increased activity of CREB1 protein CTD PMID:10559391 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Ece1 endothelin converting enzyme 1 increases expression EXP
ISO
Mimosine results in increased expression of ECE1 mRNA; Mimosine results in increased expression of ECE1 protein CTD PMID:25469848 NCBI chr 5:156,215,469...156,318,652
Ensembl chr 5:156,215,417...156,318,671
JBrowse link
G Edn1 endothelin 1 increases expression ISO
EXP
Mimosine results in increased expression of EDN1 mRNA; Mimosine results in increased expression of EDN1 protein CTD PMID:25469848 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases activity
increases expression
EXP
ISO
Mimosine results in increased activity of HIF1A protein
Mimosine results in increased expression of HIF1A protein
CTD PMID:10559391, PMID:24349381, PMID:25469848 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor decreases expression EXP
ISO
Mimosine results in decreased expression of LHCGR mRNA CTD PMID:19293332 NCBI chr 6:12,493,182...12,554,482
Ensembl chr 6:12,493,943...12,554,439
JBrowse link
G Nmbr neuromedin B receptor increases expression ISO Mimosine results in increased expression of NMBR protein CTD PMID:24349381 NCBI chr 1:8,933,744...8,945,850
Ensembl chr 1:8,933,831...8,944,987
JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression ISO
EXP
Mimosine results in increased expression of SLC2A1 mRNA CTD PMID:25469848 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation EXP Mimosine results in increased phosphorylation of STAT3 protein CTD PMID:25469848 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases activity
ISO
EXP
Acetylcysteine inhibits the reaction [Mimosine results in decreased activity of TNF protein]; ferrous sulfate inhibits the reaction [Mimosine results in decreased activity of TNF protein]
Acetylcysteine inhibits the reaction [Mimosine results in decreased activity of TNF protein]; CAT protein inhibits the reaction [Mimosine results in decreased activity of TNF protein]
CTD PMID:15550384 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions
increases cleavage
ISO Acetylcysteine inhibits the reaction [Mimosine results in increased cleavage of TNFRSF1A protein] CTD PMID:15550384 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      application 19420
        pharmaceutical 19293
          drug 19293
            antifungal drug 5145
              propionic acid 3671
                L-mimosine 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic group 18527
                              organic divalent group 18520
                                organodiyl group 18520
                                  carbonyl group 18427
                                    carbonyl compound 18427
                                      carboxylic acid 18108
                                        monocarboxylic acid 17475
                                          fatty acid 15994
                                            saturated fatty acid 15967
                                              propionic acid 3671
                                                L-mimosine 19
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