|
G |
Tgfb1 |
transforming growth factor, beta 1 |
decreases activity |
ISO |
ferbam results in decreased activity of TGFB1 protein |
CTD |
PMID:31652400 |
|
NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
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G |
Aco1 |
aconitase 1 |
increases activity decreases activity |
ISO |
ferric ammonium citrate results in increased activity of ACO1 protein ferric ammonium citrate results in decreased activity of ACO1 protein |
CTD |
PMID:11054110 PMID:18073202 |
|
NCBI chr 5:56,425,076...56,481,218
Ensembl chr 5:56,425,024...56,481,218
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G |
Aco2 |
aconitase 2 |
multiple interactions increases activity |
ISO |
ferric ammonium citrate inhibits the reaction [manganese chloride results in decreased activity of ACO2 protein]; ferric ammonium citrate inhibits the reaction [Manganese results in decreased activity of ACO2 protein] ferric ammonium citrate results in increased activity of ACO2 protein |
CTD |
PMID:16625280 |
|
NCBI chr 7:123,102,493...123,145,608
Ensembl chr 7:123,102,468...123,145,635
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|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
ferric ammonium citrate inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]] |
CTD |
PMID:32283200 |
|
NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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|
G |
Alb |
albumin |
multiple interactions |
ISO |
ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of ALB protein] |
CTD |
PMID:24862973 |
|
NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
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|
G |
Anxa3 |
annexin A3 |
multiple interactions |
ISO |
ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of ANXA3 protein] |
CTD |
PMID:19515424 |
|
NCBI chr14:14,371,921...14,426,503
Ensembl chr14:14,364,008...14,426,437
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|
G |
Arhgdia |
Rho GDP dissociation inhibitor alpha |
multiple interactions |
ISO |
ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of ARHGDIA protein] |
CTD |
PMID:19515424 |
|
NCBI chr10:109,754,012...109,757,506
Ensembl chr10:109,754,004...109,757,550
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|
G |
Bmp6 |
bone morphogenetic protein 6 |
multiple interactions |
ISO |
ferric ammonium citrate affects the reaction [Deferoxamine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]]; ferric ammonium citrate inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA] |
CTD |
PMID:25633564 |
|
NCBI chr17:26,955,142...27,112,820
Ensembl chr17:26,955,142...27,112,820
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|
G |
Casp3 |
caspase 3 |
increases cleavage multiple interactions |
ISO |
ferric ammonium citrate results in increased cleavage of CASP3 protein 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]; Deferoxamine inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]; DNM1L protein mutant form inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]; N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein] |
CTD |
PMID:17191120 PMID:26318285 PMID:27481217 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions |
ISO |
ferric ammonium citrate inhibits the reaction [2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone results in decreased expression of CDKN1A protein] |
CTD |
PMID:12807743 |
|
NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
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|
G |
Col1a1 |
collagen type I alpha 1 chain |
decreases expression |
ISO |
ferric ammonium citrate results in decreased expression of COL1A1 mRNA |
CTD |
PMID:19735707 |
|
NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
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G |
Dnm1l |
dynamin 1-like |
multiple interactions decreases phosphorylation |
ISO |
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]; Cyclosporine inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]; Deferoxamine inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]; DNM1L protein mutant form inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]; ferric ammonium citrate results in decreased phosphorylation of and affects the localization of DNM1L protein; N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]; Tacrolimus inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein] |
CTD |
PMID:26318285 PMID:27481217 |
|
NCBI chr11:88,830,968...88,882,271
Ensembl chr11:88,830,957...88,880,198
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|
G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
multiple interactions |
ISO |
ferric ammonium citrate inhibits the reaction [Palmitic Acid results in increased phosphorylation of ERN1 protein] |
CTD |
PMID:32283200 |
|
NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
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G |
Erp29 |
endoplasmic reticulum protein 29 |
multiple interactions |
ISO |
ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of ERP29 protein] |
CTD |
PMID:19515424 |
|
NCBI chr12:40,619,377...40,625,884
Ensembl chr12:40,619,377...40,625,883
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G |
F3 |
coagulation factor III, tissue factor |
increases expression multiple interactions |
ISO |
ferric ammonium citrate results in increased expression of F3 mRNA Deferoxamine inhibits the reaction [ferric ammonium citrate results in increased expression of F3 mRNA] |
CTD |
PMID:25858758 |
|
NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
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|
G |
Fth1 |
ferritin heavy chain 1 |
multiple interactions |
ISO |
ferric ammonium citrate promotes the reaction [Palmitic Acid results in increased expression of FTH1 protein] |
CTD |
PMID:32283200 |
|
NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
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G |
Ftl1 |
ferritin light chain 1 |
multiple interactions increases expression |
ISO |
[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of FTL mRNA ferric ammonium citrate results in increased expression of FTL1 mRNA SLC40A1 protein inhibits the reaction [ferric ammonium citrate results in increased expression of FTL1 mRNA] |
CTD |
PMID:12393473 PMID:19913091 |
|
NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
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|
G |
Gapdh |
glyceraldehyde-3-phosphate dehydrogenase |
multiple interactions |
ISO |
ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of GAPDH protein] |
CTD |
PMID:19515424 |
|
NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
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|
G |
Glo1 |
glyoxalase 1 |
multiple interactions |
ISO |
ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of GLO1 protein] |
CTD |
PMID:19515424 |
|
NCBI chr20:9,273,589...9,291,608
Ensembl chr20:9,273,594...9,291,610
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G |
Hamp |
hepcidin antimicrobial peptide |
multiple interactions decreases expression |
ISO |
Deferoxamine promotes the reaction [ferric ammonium citrate results in decreased expression of HAMP mRNA]; ferric ammonium citrate affects the reaction [Deferoxamine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]]; ferric ammonium citrate inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA] |
CTD |
PMID:25633564 |
|
NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
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|
G |
Hmox1 |
heme oxygenase 1 |
increases expression multiple interactions |
EXP ISO |
ferric ammonium citrate results in increased expression of HMOX1 protein [ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of HMOX1 mRNA N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [ferric ammonium citrate results in increased expression of HMOX1 protein] |
CTD |
PMID:12393473 PMID:16439612 |
|
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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|
G |
Hspa1a |
heat shock protein family A (Hsp70) member 1A |
multiple interactions |
ISO |
ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of HSPA1A protein] |
CTD |
PMID:19515424 |
|
NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
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|
G |
Hspa1l |
heat shock protein family A (Hsp70) member 1 like |
multiple interactions |
ISO |
[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of HSPA1L mRNA |
CTD |
PMID:12393473 |
|
NCBI chr20:4,879,998...4,965,191
Ensembl chr20:4,959,294...4,964,963
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|
G |
Hspa9 |
heat shock protein family A (Hsp70) member 9 |
multiple interactions |
ISO |
[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of HSPA9 mRNA |
CTD |
PMID:12393473 |
|
NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235
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|
G |
Hspd1 |
heat shock protein family D (Hsp60) member 1 |
multiple interactions |
ISO |
ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of HSPD1 protein] |
CTD |
PMID:19515424 |
|
NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
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|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of IL1B protein] |
CTD |
PMID:24862973 |
|
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of IL6 mRNA]; ferric ammonium citrate inhibits the reaction [Ozone results in increased secretion of IL6 protein] |
CTD |
PMID:24862973 |
|
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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|
G |
Ins2 |
insulin 2 |
multiple interactions |
ISO |
ferric ammonium citrate inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]]; ferric ammonium citrate inhibits the reaction [Palmitic Acid inhibits the reaction [INS1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]]; Thapsigargin inhibits the reaction [ferric ammonium citrate inhibits the reaction [Palmitic Acid inhibits the reaction [INS1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]]] |
CTD |
PMID:32283200 |
|
NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
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|
G |
Ireb2 |
iron responsive element binding protein 2 |
decreases expression decreases activity |
EXP ISO |
ferric ammonium citrate results in decreased expression of IREB2 protein ferric ammonium citrate results in decreased activity of IREB2 protein |
CTD |
PMID:11054110 PMID:17469137 PMID:18073202 |
|
NCBI chr 8:59,450,974...59,503,634
Ensembl chr 8:59,420,123...59,501,118
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|
G |
Lcn2 |
lipocalin 2 |
multiple interactions |
ISO |
ferric ammonium citrate inhibits the reaction [bathophenanthroline disulfonic acid results in decreased expression of LCN2 protein] |
CTD |
PMID:17350462 |
|
NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions increases phosphorylation |
ISO |
[ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in decreased phosphorylation of MAPK1 protein ferric ammonium citrate results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:17191120 PMID:25858758 |
|
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk14 |
mitogen activated protein kinase 14 |
increases phosphorylation |
ISO |
ferric ammonium citrate results in increased phosphorylation of MAPK14 protein |
CTD |
PMID:17191120 |
|
NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions increases phosphorylation |
ISO |
[ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in decreased phosphorylation of MAPK3 protein ferric ammonium citrate results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:17191120 PMID:25858758 |
|
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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|
G |
Mrps9 |
mitochondrial ribosomal protein S9 |
multiple interactions |
ISO |
ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of MRPS9 protein] |
CTD |
PMID:19515424 |
|
NCBI chr 9:49,647,257...49,704,828
Ensembl chr 9:49,647,257...49,704,828
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|
G |
Mt2A |
metallothionein 2A |
multiple interactions |
ISO |
[ferric ammonium citrate results in decreased abundance of Iron] which results in increased expression of MT2A mRNA |
CTD |
PMID:12393473 |
|
NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
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|
G |
Ncoa4 |
nuclear receptor coactivator 4 |
multiple interactions |
ISO |
ferric ammonium citrate inhibits the reaction [Palmitic Acid results in increased expression of NCOA4 protein] |
CTD |
PMID:32283200 |
|
NCBI chr16:8,302,950...8,323,294
Ensembl chr16:8,302,950...8,323,293
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
[ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in increased expression of NOS2 mRNA; Acetylcysteine inhibits the reaction [[ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in increased expression of NOS2 mRNA] |
CTD |
PMID:9826428 |
|
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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G |
Oga |
O-GlcNAcase |
multiple interactions |
ISO |
ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of OGA protein] |
CTD |
PMID:24862973 |
|
NCBI chr 1:265,506,752...265,542,452
Ensembl chr 1:265,507,451...265,542,276
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G |
P4ha1 |
prolyl 4-hydroxylase subunit alpha 1 |
multiple interactions |
ISO |
ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of P4HA1 protein] |
CTD |
PMID:19515424 |
|
NCBI chr20:28,920,616...28,972,576
Ensembl chr20:28,920,616...28,971,966
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G |
Pdhb |
pyruvate dehydrogenase E1 subunit beta |
multiple interactions |
ISO |
ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of PDHB protein] |
CTD |
PMID:19515424 |
|
NCBI chr15:18,540,826...18,546,855
Ensembl chr15:18,539,210...18,546,854
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G |
Pgk1 |
phosphoglycerate kinase 1 |
multiple interactions |
ISO |
ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of PGK1 protein] |
CTD |
PMID:19515424 |
|
NCBI chr X:77,263,399...77,279,373
Ensembl chr X:77,263,359...77,279,367
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|
G |
Pmp22 |
peripheral myelin protein 22 |
multiple interactions |
ISO |
[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of PMP22 mRNA |
CTD |
PMID:12393473 |
|
NCBI chr10:49,538,588...49,568,583
Ensembl chr10:49,538,588...49,568,583
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|
G |
Ppia |
peptidylprolyl isomerase A |
multiple interactions |
ISO |
ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of PPIA protein] |
CTD |
PMID:19515424 |
|
NCBI chr14:86,673,775...86,677,443
Ensembl chr14:86,673,775...86,677,443
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|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of PTGS2 mRNA] |
CTD |
PMID:24862973 |
|
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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G |
Rack1 |
receptor for activated C kinase 1 |
multiple interactions |
ISO |
ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of RACK1 protein] |
CTD |
PMID:19515424 |
|
NCBI chr10:34,149,717...34,155,198
Ensembl chr10:34,149,717...34,155,198 Ensembl chr12:34,149,717...34,155,198
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G |
Slc11a1 |
solute carrier family 11 member 1 |
increases expression |
ISO |
ferric ammonium citrate results in increased expression of SLC11A1 mRNA |
CTD |
PMID:11054110 |
|
NCBI chr 9:81,655,590...81,666,697
Ensembl chr 9:81,655,629...81,666,706
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G |
Slc11a2 |
solute carrier family 11 member 2 |
increases expression |
ISO |
ferric ammonium citrate results in increased expression of SLC11A2 mRNA |
CTD |
PMID:11054110 |
|
NCBI chr 7:142,025,812...142,062,892
Ensembl chr 7:142,025,815...142,063,212
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G |
Slc40a1 |
solute carrier family 40 member 1 |
increases expression multiple interactions |
EXP ISO |
ferric ammonium citrate results in increased expression of SLC40A1 mRNA SLC40A1 protein inhibits the reaction [ferric ammonium citrate results in increased expression of FTL1 mRNA] |
CTD |
PMID:19913091 |
|
NCBI chr 9:52,819,451...52,830,461
Ensembl chr 9:52,894,365...52,912,293
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|
G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
ISO |
ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of SOD1 mRNA] |
CTD |
PMID:24862973 |
|
NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
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G |
Tf |
transferrin |
multiple interactions |
ISO |
ferric ammonium citrate inhibits the reaction [TF protein results in increased uptake of Iron] |
CTD |
PMID:11335103 |
|
NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
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|
G |
Tfr2 |
transferrin receptor 2 |
decreases expression |
ISO |
ferric ammonium citrate results in decreased expression of TFR2 protein |
CTD |
PMID:25633564 |
|
NCBI chr12:22,177,382...22,194,330
Ensembl chr12:22,177,382...22,194,299
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G |
Tfrc |
transferrin receptor |
decreases expression multiple interactions |
ISO |
ferric ammonium citrate results in decreased expression of TFRC mRNA; ferric ammonium citrate results in decreased expression of TFRC protein [ferric ammonium citrate results in decreased abundance of Iron] which results in increased expression of TFRC mRNA |
CTD |
PMID:11054110 PMID:12393473 PMID:16760464 PMID:18073202 PMID:25633564 |
|
NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
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|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of TNF protein] |
CTD |
PMID:24862973 |
|
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
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G |
Tpd52l1 |
TPD52 like 1 |
multiple interactions |
ISO |
ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of TPD52L1 protein] |
CTD |
PMID:19515424 |
|
NCBI chr 1:28,454,949...28,578,736
Ensembl chr 1:28,454,966...28,576,553
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|
G |
Vdac2 |
voltage-dependent anion channel 2 |
multiple interactions |
ISO |
ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of VDAC2 protein] |
CTD |
PMID:19515424 |
|
NCBI chr15:2,634,622...2,648,548
Ensembl chr15:2,634,624...2,648,551
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|
G |
Xbp1 |
X-box binding protein 1 |
multiple interactions |
ISO |
ferric ammonium citrate inhibits the reaction [Palmitic Acid results in increased expression of XBP1 protein] |
CTD |
PMID:32283200 |
|
NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
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|
|
G |
Aco1 |
aconitase 1 |
multiple interactions |
ISO |
ferric sulfate inhibits the reaction [Nickel results in increased activity of ACO1 protein] |
CTD |
PMID:16877034 |
|
NCBI chr 5:56,425,076...56,481,218
Ensembl chr 5:56,425,024...56,481,218
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|
G |
Got1 |
glutamic-oxaloacetic transaminase 1 |
multiple interactions increases activity |
EXP |
Capsaicin inhibits the reaction [ferric sulfate results in increased activity of GOT1 protein]; Curcumin inhibits the reaction [ferric sulfate results in increased activity of GOT1 protein] |
CTD |
PMID:16956363 |
|
NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762
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|
G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions increases activity |
EXP |
Capsaicin inhibits the reaction [ferric sulfate results in increased activity of GPT protein]; Curcumin inhibits the reaction [ferric sulfate results in increased activity of GPT protein] |
CTD |
PMID:16956363 |
|
NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
ISO |
ferric sulfate inhibits the reaction [Nickel results in increased stability of HIF1A protein] |
CTD |
PMID:16877034 |
|
NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
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|
G |
Alb |
albumin |
increases secretion multiple interactions increases expression |
ISO |
ferric citrate results in increased secretion of ALB protein Alcohols inhibits the reaction [ferric citrate results in increased expression of ALB mRNA]; Alcohols inhibits the reaction [ferric citrate results in increased secretion of ALB protein]; ferric citrate inhibits the reaction [Alcohols results in increased expression of ALB mRNA]; ferric citrate inhibits the reaction [Alcohols results in increased secretion of ALB protein] |
CTD |
PMID:24025710 |
|
NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
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|
G |
Aldob |
aldolase, fructose-bisphosphate B |
increases expression multiple interactions |
ISO |
ferric citrate results in increased expression of ALDOB mRNA Alcohols inhibits the reaction [ferric citrate results in increased expression of ALDOB mRNA]; ferric citrate inhibits the reaction [Alcohols results in increased expression of ALDOB mRNA] |
CTD |
PMID:24025710 |
|
NCBI chr 5:64,805,772...64,818,813
Ensembl chr 5:64,805,773...64,818,824
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|
G |
Aqp4 |
aquaporin 4 |
decreases expression |
ISO |
ferric citrate results in decreased expression of AQP4 mRNA |
CTD |
PMID:29959986 |
|
NCBI chr18:6,766,009...6,782,757
Ensembl chr18:6,765,945...6,782,996
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G |
Ca9 |
carbonic anhydrase 9 |
decreases expression |
ISO |
ferric citrate results in decreased expression of CA9 mRNA |
CTD |
PMID:29959986 |
|
NCBI chr 5:59,008,277...59,015,535
Ensembl chr 5:59,008,933...59,015,528
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
decreases expression |
ISO |
ferric citrate results in decreased expression of CCL2 mRNA |
CTD |
PMID:29959986 |
|
NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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G |
Cftr |
CF transmembrane conductance regulator |
decreases expression |
ISO |
ferric citrate results in decreased expression of CFTR mRNA |
CTD |
PMID:29959986 |
|
NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
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G |
Crp |
C-reactive protein |
increases expression |
ISO |
ferric citrate results in increased expression of CRP mRNA |
CTD |
PMID:29959986 |
|
NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions increases expression |
ISO |
Alcohols inhibits the reaction [ferric citrate results in increased expression of CYP2E1 mRNA]; ferric citrate inhibits the reaction [Alcohols results in increased expression of CYP2E1 mRNA] |
CTD |
PMID:24025710 |
|
NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
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G |
Cyp3a62 |
cytochrome P450, family 3, subfamily a, polypeptide 62 |
increases expression multiple interactions |
ISO |
ferric citrate results in increased expression of CYP3A4 mRNA; ferric citrate results in increased expression of CYP3A4 protein Alcohols inhibits the reaction [ferric citrate results in increased expression of CYP3A4 mRNA]; Alcohols promotes the reaction [ferric citrate results in increased expression of CYP3A4 protein]; ferric citrate inhibits the reaction [Alcohols results in increased expression of CYP3A4 mRNA]; ferric citrate promotes the reaction [Alcohols results in increased expression of CYP3A4 protein] |
CTD |
PMID:24025710 |
|
NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions |
ISO |
[trigonelline co-treated with ferric citrate] results in increased expression of DDIT3 mRNA |
CTD |
PMID:29959986 |
|
NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
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G |
Edn1 |
endothelin 1 |
decreases expression |
ISO |
ferric citrate results in decreased expression of EDN1 mRNA |
CTD |
PMID:29959986 |
|
NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
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G |
Epo |
erythropoietin |
increases expression |
ISO |
ferric citrate results in increased expression of EPO mRNA |
CTD |
PMID:29959986 |
|
NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
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G |
F10 |
coagulation factor X |
decreases activity |
ISO |
ferric citrate results in decreased activity of F10 protein |
CTD |
PMID:6421970 |
|
NCBI chr16:81,803,169...81,822,476
Ensembl chr16:81,803,110...81,822,716
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G |
F2 |
coagulation factor II |
decreases activity |
ISO |
ferric citrate results in decreased activity of F2 protein |
CTD |
PMID:6421970 |
|
NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
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G |
Fth1 |
ferritin heavy chain 1 |
increases expression multiple interactions |
ISO |
ferric citrate results in increased expression of FTH1 mRNA [trigonelline co-treated with ferric citrate] results in increased expression of FTH1 mRNA |
CTD |
PMID:29959986 |
|
NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
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G |
Ftl1 |
ferritin light chain 1 |
multiple interactions |
ISO |
[trigonelline co-treated with ferric citrate] results in increased expression of FTL mRNA |
CTD |
PMID:29959986 |
|
NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression |
ISO |
ferric citrate results in increased expression of GCLM mRNA |
CTD |
PMID:29959986 |
|
NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
ISO |
ferric citrate inhibits the reaction [Deferoxamine results in increased expression of HIF1A protein] ferric citrate inhibits the reaction [Deferoxamine results in increased expression of HIF1A protein]; ferric citrate inhibits the reaction [Quercetin results in increased expression of HIF1A mRNA]; ferric citrate inhibits the reaction [Quercetin results in increased expression of HIF1A protein] |
CTD |
PMID:16527254 PMID:17015263 PMID:17364964 |
|
NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
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|
G |
Hmox1 |
heme oxygenase 1 |
increases expression |
ISO |
ferric citrate results in increased expression of HMOX1 mRNA |
CTD |
PMID:29959986 |
|
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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G |
Il1a |
interleukin 1 alpha |
decreases expression |
ISO |
ferric citrate results in decreased expression of IL1A mRNA |
CTD |
PMID:29959986 |
|
NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
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|
G |
Keap1 |
Kelch-like ECH-associated protein 1 |
multiple interactions |
ISO |
[trigonelline co-treated with ferric citrate] results in decreased expression of KEAP1 mRNA |
CTD |
PMID:29959986 |
|
NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
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G |
Klk1 |
kallikrein 1 |
decreases activity |
ISO |
ferric citrate results in decreased activity of KLK1 protein |
CTD |
PMID:6421970 |
|
NCBI chr 1:100,131,562...100,135,556
Ensembl chr 1:100,059,967...100,203,329 Ensembl chr 1:100,059,967...100,203,329 Ensembl chr 1:100,059,967...100,203,329
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|
G |
Nfe2l2 |
nuclear factor, erythroid 2-like 2 |
affects localization multiple interactions |
ISO |
ferric citrate affects the localization of NFE2L2 protein trigonelline inhibits the reaction [ferric citrate affects the localization of NFE2L2 protein] |
CTD |
PMID:29959986 |
|
NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
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|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression multiple interactions |
ISO |
ferric citrate results in increased expression of NQO1 mRNA; ferric citrate results in increased expression of NQO1 protein trigonelline inhibits the reaction [ferric citrate results in increased expression of NQO1 protein] |
CTD |
PMID:29959986 |
|
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
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|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
ferric citrate inhibits the reaction [Deferoxamine results in increased expression of PTGS2 protein] |
CTD |
PMID:16527254 |
|
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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|
G |
Serpine1 |
serpin family E member 1 |
decreases expression |
ISO |
ferric citrate results in decreased expression of SERPINE1 mRNA |
CTD |
PMID:29959986 |
|
NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
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|
G |
Sqstm1 |
sequestosome 1 |
increases expression |
ISO |
ferric citrate results in increased expression of SQSTM1 mRNA |
CTD |
PMID:29959986 |
|
NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
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|
G |
Tf |
transferrin |
increases expression |
ISO |
ferric citrate results in increased expression of TF mRNA |
CTD |
PMID:24025710 |
|
NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
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G |
Tfrc |
transferrin receptor |
increases expression multiple interactions |
ISO |
ferric citrate results in increased expression of TFRC protein ferric citrate inhibits the reaction [Quercetin results in increased expression of TFRC protein] |
CTD |
PMID:17364964 PMID:29959986 |
|
NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
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|
G |
Tnf |
tumor necrosis factor |
decreases expression |
ISO |
ferric citrate results in decreased expression of TNF mRNA |
CTD |
PMID:29959986 |
|
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
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|
G |
Txnrd1 |
thioredoxin reductase 1 |
increases expression |
ISO |
ferric citrate results in increased expression of TXNRD1 mRNA |
CTD |
PMID:29959986 |
|
NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions |
ISO |
ferric nitrilotriacetate inhibits the reaction [Asbestos, Crocidolite results in increased expression of ABCB1 protein]; ferric nitrilotriacetate inhibits the reaction [Razoxane results in increased expression of ABCB1 protein] |
CTD |
PMID:18385176 |
|
NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
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|
G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
increases expression |
ISO |
ferric nitrilotriacetate results in increased expression of ABCC1 mRNA |
CTD |
PMID:18617210 |
|
NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
increases expression |
ISO |
ferric nitrilotriacetate results in increased expression of ABCC2 mRNA |
CTD |
PMID:18617210 |
|
NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
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G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
increases expression |
ISO |
ferric nitrilotriacetate results in increased expression of ABCC4 mRNA |
CTD |
PMID:18617210 |
|
NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
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G |
Anxa2 |
annexin A2 |
increases expression |
EXP |
ferric nitrilotriacetate results in increased expression of ANXA2 mRNA |
CTD |
PMID:10854235 |
|
NCBI chr 8:75,687,134...75,723,589
Ensembl chr 8:75,687,100...75,723,594
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
EXP |
ferric nitrilotriacetate results in increased expression of BAX mRNA |
CTD |
PMID:23208426 |
|
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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G |
Bbc3 |
Bcl-2 binding component 3 |
increases expression |
EXP |
ferric nitrilotriacetate results in increased expression of BBC3 mRNA |
CTD |
PMID:23208426 |
|
NCBI chr 1:78,261,491...78,267,802
|
|
G |
Bik |
BCL2-interacting killer |
increases expression |
EXP |
ferric nitrilotriacetate results in increased expression of BIK mRNA |
CTD |
PMID:23208426 |
|
NCBI chr 7:124,390,924...124,410,449
Ensembl chr 7:124,391,432...124,410,447
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G |
Cald1 |
caldesmon 1 |
increases expression |
EXP |
ferric nitrilotriacetate results in increased expression of CALD1 mRNA |
CTD |
PMID:10854235 |
|
NCBI chr 4:62,103,948...62,291,375
Ensembl chr 4:62,220,736...62,291,489
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G |
Canx |
calnexin |
increases expression |
EXP |
ferric nitrilotriacetate results in increased expression of CANX protein |
CTD |
PMID:16908007 |
|
NCBI chr10:35,800,942...35,833,939
Ensembl chr10:35,800,942...35,833,861
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G |
Casp12 |
caspase 12 |
increases expression |
EXP |
ferric nitrilotriacetate results in increased expression of CASP12 mRNA |
CTD |
PMID:23208426 |
|
NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
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G |
Casp3 |
caspase 3 |
multiple interactions |
EXP |
[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP3 protein; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP3 mRNA; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP3 protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP3 mRNA] |
CTD |
PMID:21907755 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Casp8 |
caspase 8 |
multiple interactions |
EXP |
[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP8 protein; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP8 mRNA; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP8 protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP8 mRNA] |
CTD |
PMID:21907755 |
|
NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
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G |
Casp9 |
caspase 9 |
multiple interactions |
EXP |
[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP9 protein; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP9 mRNA; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP9 protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP9 mRNA] |
CTD |
PMID:21907755 |
|
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
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G |
Cat |
catalase |
multiple interactions decreases activity |
EXP |
[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of CAT protein; chrysin inhibits the reaction [ferric nitrilotriacetate results in decreased activity of CAT protein]; geraniol inhibits the reaction [ferric nitrilotriacetate results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of CAT protein]; Quercetin inhibits the reaction [ferric nitrilotriacetate results in decreased activity of CAT protein] |
CTD |
PMID:9667754 PMID:15198074 PMID:18684806 PMID:21907755 PMID:23194824 PMID:30098279 |
|
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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G |
Ccnd1 |
cyclin D1 |
increases expression |
EXP |
ferric nitrilotriacetate results in increased expression of CCND1 mRNA; ferric nitrilotriacetate results in increased expression of CCND1 protein |
CTD |
PMID:18055543 |
|
NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
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G |
Cd44 |
CD44 molecule (Indian blood group) |
increases expression |
EXP |
ferric nitrilotriacetate results in increased expression of CD44 mRNA; ferric nitrilotriacetate results in increased expression of CD44 protein |
CTD |
PMID:18055543 |
|
NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
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G |
Cd47 |
Cd47 molecule |
increases expression |
EXP |
ferric nitrilotriacetate results in increased expression of CD47 mRNA |
CTD |
PMID:9119739 |
|
NCBI chr11:53,511,485...53,575,754
Ensembl chr11:53,514,595...53,575,175
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
EXP |
ferric nitrilotriacetate results in increased expression of CDKN1A mRNA |
CTD |
PMID:23208426 |
|
NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
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G |
Chrm1 |
cholinergic receptor, muscarinic 1 |
decreases expression |
EXP |
ferric nitrilotriacetate results in decreased expression of CHRM1 mRNA |
CTD |
PMID:19490752 |
|
NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
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G |
Chrm2 |
cholinergic receptor, muscarinic 2 |
decreases expression |
EXP |
ferric nitrilotriacetate results in decreased expression of CHRM2 mRNA |
CTD |
PMID:19490752 |
|
NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
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G |
Col1a1 |
collagen type I alpha 1 chain |
increases expression multiple interactions |
EXP |
ferric nitrilotriacetate results in increased expression of COL1A1 protein ethylisopropylamiloride inhibits the reaction [ferric nitrilotriacetate results in increased expression of COL1A1 protein] |
CTD |
PMID:11159895 |
|
NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
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G |
Cygb |
cytoglobin |
multiple interactions |
EXP |
CYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TGFB1 mRNA]; CYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TIMP1 mRNA]; CYGB protein results in decreased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid] |
CTD |
PMID:16581302 |
|
NCBI chr10:105,618,325...105,628,091
Ensembl chr10:105,618,326...105,628,091
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions |
ISO |
[[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT18 protein; [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT8 protein; [Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein; allyl sulfide inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]]; CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]; Ditiocarb inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]] |
CTD |
PMID:12086689 PMID:17034788 PMID:21352821 |
|
NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
ferric nitrilotriacetate results in increased expression of FOS mRNA |
CTD |
PMID:10381381 |
|
NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
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G |
Fosl1 |
FOS like 1, AP-1 transcription factor subunit |
increases expression |
EXP |
ferric nitrilotriacetate results in increased expression of FOSL1 mRNA; ferric nitrilotriacetate results in increased expression of FOSL1 protein |
CTD |
PMID:18055543 |
|
NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
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G |
G6pd |
glucose-6-phosphate dehydrogenase |
decreases activity |
EXP |
ferric nitrilotriacetate results in decreased activity of G6PD protein |
CTD |
PMID:9667754 |
|
NCBI chr X:156,274,800...156,293,935
Ensembl chr X:156,274,800...156,293,926
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression |
ISO |
ferric nitrilotriacetate results in increased expression of GCLC mRNA |
CTD |
PMID:18617210 |
|
NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
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G |
Gsr |
glutathione-disulfide reductase |
decreases activity multiple interactions |
EXP |
ferric nitrilotriacetate results in decreased activity of GSR protein [Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of GSR protein; Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of GSR protein]; Quercetin inhibits the reaction [ferric nitrilotriacetate results in decreased activity of GSR protein] |
CTD |
PMID:9667754 PMID:15198074 PMID:30098279 |
|
NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
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G |
Gtse1 |
G-2 and S-phase expressed 1 |
increases expression |
EXP |
ferric nitrilotriacetate results in increased expression of GTSE1 mRNA |
CTD |
PMID:23208426 |
|
NCBI chr 7:126,736,416...126,753,221
Ensembl chr 7:126,736,732...126,753,220
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G |
Havcr1 |
hepatitis A virus cellular receptor 1 |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased secretion of HAVCR1 protein; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of HAVCR1 mRNA; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of HAVCR1 protein; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of HAVCR1 mRNA]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of HAVCR1 protein]; Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased secretion of HAVCR1 protein] |
CTD |
PMID:21907755 PMID:30098279 |
|
NCBI chr10:31,813,819...31,860,934
Ensembl chr10:31,813,814...31,848,379
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
ISO |
ferric nitrilotriacetate inhibits the reaction [Asbestos, Crocidolite results in increased activity of HIF1A protein]; ferric nitrilotriacetate inhibits the reaction [Razoxane results in increased activity of HIF1A protein] |
CTD |
PMID:18385176 |
|
NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
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G |
Hmox1 |
heme oxygenase 1 |
increases expression |
EXP ISO |
ferric nitrilotriacetate results in increased expression of HMOX1 mRNA |
CTD |
PMID:18617210 PMID:19490752 |
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NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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Hsp90aa1 |
heat shock protein 90 alpha family class A member 1 |
increases expression |
EXP |
ferric nitrilotriacetate results in increased expression of HSP90AA1 mRNA |
CTD |
PMID:10854235 |
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NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775 Ensembl chr 6:135,107,271...135,112,775
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Il24 |
interleukin 24 |
increases expression |
EXP |
ferric nitrilotriacetate results in increased expression of IL24 mRNA |
CTD |
PMID:23208426 |
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NCBI chr13:47,618,451...47,623,849
Ensembl chr13:47,618,452...47,623,849
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Il6 |
interleukin 6 |
increases expression multiple interactions |
ISO EXP |
ferric nitrilotriacetate results in increased expression of IL6 protein ferric nitrilotriacetate results in increased expression of IL6 mRNA [Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of IL6 protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of IL6 protein] |
CTD |
PMID:15781289 PMID:19490752 PMID:23194824 |
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NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases expression |
EXP |
ferric nitrilotriacetate results in increased expression of JUN mRNA; ferric nitrilotriacetate results in increased expression of JUN protein |
CTD |
PMID:18055543 |
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NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
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G |
Krt18 |
keratin 18 |
multiple interactions |
ISO |
[[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT18 protein |
CTD |
PMID:17034788 |
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NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
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G |
Krt8 |
keratin 8 |
multiple interactions |
ISO |
[[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT8 protein |
CTD |
PMID:17034788 |
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NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803
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G |
Mcm3 |
minichromosome maintenance complex component 3 |
increases expression |
EXP |
ferric nitrilotriacetate results in increased expression of MCM3 mRNA |
CTD |
PMID:23208426 |
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NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201
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G |
Mt1 |
metallothionein 1 |
multiple interactions |
ISO |
[ferric nitrilotriacetate co-treated with Hydrogen Peroxide] inhibits the reaction [MT1 protein binds to Cadmium]; [ferric nitrilotriacetate co-treated with Hydrogen Peroxide] inhibits the reaction [MT1 protein binds to Zinc]; ferric nitrilotriacetate results in increased oxidation of [MT1 protein binds to Zinc] |
CTD |
PMID:22001350 |
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NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
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G |
Mt2A |
metallothionein 2A |
multiple interactions |
ISO |
[ferric nitrilotriacetate co-treated with Hydrogen Peroxide] inhibits the reaction [MT2 protein binds to Cadmium] |
CTD |
PMID:22001350 |
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NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
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G |
Mt3 |
metallothionein 3 |
decreases response to substance |
ISO |
MT3 protein results in decreased susceptibility to ferric nitrilotriacetate |
CTD |
PMID:12383939 |
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NCBI chr19:11,324,708...11,326,112
Ensembl chr19:11,324,698...11,326,139
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
increases expression |
EXP |
ferric nitrilotriacetate results in increased expression of MYC mRNA; ferric nitrilotriacetate results in increased expression of MYC protein |
CTD |
PMID:18055543 |
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NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
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G |
Nfe2l2 |
nuclear factor, erythroid 2-like 2 |
affects localization |
ISO |
ferric nitrilotriacetate affects the localization of NFE2L2 protein |
CTD |
PMID:18617210 |
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NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
EXP |
[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of NFKB1 mRNA; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of NFKB1 mRNA] |
CTD |
PMID:21907755 |
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NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions increases expression |
ISO EXP |
ferric nitrilotriacetate inhibits the reaction [Doxorubicin results in increased expression of NOS2 mRNA]; ferric nitrilotriacetate inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein]; ferric nitrilotriacetate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] ferric nitrilotriacetate results in increased expression of NOS2 protein [Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of NOS2 protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of NOS2 protein]; chrysin inhibits the reaction [ferric nitrilotriacetate results in increased expression of NOS2 protein]; ferric nitrilotriacetate promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; ferric nitrilotriacetate promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] |
CTD |
PMID:11461780 PMID:11746204 PMID:12490132 PMID:23194824 |
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NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression |
ISO |
ferric nitrilotriacetate results in increased expression of NQO1 mRNA; ferric nitrilotriacetate results in increased expression of NQO1 protein |
CTD |
PMID:18617210 |
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NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
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G |
Odc1 |
ornithine decarboxylase 1 |
multiple interactions increases activity |
EXP |
[ferric nitrilotriacetate results in increased abundance of Hydroxyl Radical] which results in increased activity of ODC1 protein; Active Hexose Correlated Compound inhibits the reaction [[ferric nitrilotriacetate results in increased abundance of Hydroxyl Radical] which results in increased activity of ODC1 protein]; Vitamin E inhibits the reaction [ferric nitrilotriacetate results in increased activity of ODC1 protein] |
CTD |
PMID:9667754 PMID:14623030 PMID:15949125 |
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NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
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G |
Pck1 |
phosphoenolpyruvate carboxykinase 1 |
increases expression |
EXP |
ferric nitrilotriacetate results in increased expression of PCK1 mRNA |
CTD |
PMID:16960379 |
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NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
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G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PCNA protein; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of PCNA mRNA; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of PCNA protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PCNA protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of PCNA mRNA]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of PCNA protein] |
CTD |
PMID:21907755 PMID:23194824 |
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NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
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G |
Phlda3 |
pleckstrin homology-like domain, family A, member 3 |
increases expression |
EXP |
ferric nitrilotriacetate results in increased expression of PHLDA3 mRNA |
CTD |
PMID:23208426 |
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NCBI chr13:52,588,917...52,592,002
Ensembl chr13:52,588,917...52,592,001
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G |
Plau |
plasminogen activator, urokinase |
multiple interactions increases expression increases activity |
ISO |
Deferoxamine inhibits the reaction [ferric nitrilotriacetate results in increased activity of PLAU mRNA]; Deferoxamine inhibits the reaction [ferric nitrilotriacetate results in increased expression of PLAU mRNA] |
CTD |
PMID:17571974 |
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NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
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G |
Plk2 |
polo-like kinase 2 |
increases expression |
EXP |
ferric nitrilotriacetate results in increased expression of PLK2 mRNA |
CTD |
PMID:23208426 |
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NCBI chr 2:41,911,143...41,916,901
Ensembl chr 2:41,911,131...41,916,901
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G |
Pola1 |
DNA polymerase alpha 1, catalytic subunit |
increases expression |
EXP |
ferric nitrilotriacetate results in increased expression of POLA1 mRNA |
CTD |
PMID:10854235 |
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NCBI chr X:62,382,604...62,698,830
Ensembl chr X:62,382,608...62,698,830
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G |
Ppia |
peptidylprolyl isomerase A |
increases expression |
EXP |
ferric nitrilotriacetate results in increased expression of PPIA protein |
CTD |
PMID:16908007 |
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NCBI chr14:86,673,775...86,677,443
Ensembl chr14:86,673,775...86,677,443
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions increases expression |
EXP |
[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PTGS2 protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PTGS2 protein]; chrysin inhibits the reaction [ferric nitrilotriacetate results in increased expression of PTGS2 protein]; Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PTGS2 protein] |
CTD |
PMID:23194824 PMID:30098279 |
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NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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G |
Ptprb |
protein tyrosine phosphatase, receptor type, B |
decreases expression |
EXP |
ferric nitrilotriacetate results in decreased expression of PTPRB mRNA |
CTD |
PMID:10854235 |
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NCBI chr 7:59,326,484...59,431,114
Ensembl chr 7:59,326,518...59,425,718
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G |
Ptprz1 |
protein tyrosine phosphatase, receptor type Z1 |
increases expression |
EXP |
ferric nitrilotriacetate results in increased expression of PTPRZ1 mRNA; ferric nitrilotriacetate results in increased expression of PTPRZ1 protein |
CTD |
PMID:18055543 |
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NCBI chr 4:49,941,046...50,140,764
Ensembl chr 4:49,941,304...50,140,762
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased localization of RELA protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased localization of RELA protein] |
CTD |
PMID:23194824 |
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NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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G |
Rpl19 |
ribosomal protein L19 |
increases expression |
EXP |
ferric nitrilotriacetate results in increased expression of RPL19 mRNA |
CTD |
PMID:10854235 |
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NCBI chr10:85,978,691...85,981,979
Ensembl chr10:85,978,691...85,981,979
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G |
Rprm |
reprimo, TP53 dependent G2 arrest mediator homolog |
increases expression |
EXP |
ferric nitrilotriacetate results in increased expression of RPRM mRNA |
CTD |
PMID:23208426 |
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NCBI chr 3:39,595,301...39,596,718
Ensembl chr 3:39,595,301...39,596,718
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G |
Rps13 |
ribosomal protein S13 |
increases expression |
EXP |
ferric nitrilotriacetate results in increased expression of RPS13 mRNA |
CTD |
PMID:10854235 |
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NCBI chr 1:185,328,902...185,331,332
Ensembl chr 3:4,341,249...4,341,771
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G |
Rps15 |
ribosomal protein S15 |
increases expression |
EXP |
ferric nitrilotriacetate results in increased expression of RPS15 mRNA |
CTD |
PMID:10854235 |
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NCBI chr 7:12,282,134...12,283,573
Ensembl chr 7:12,282,109...12,283,608
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G |
Slc11a2 |
solute carrier family 11 member 2 |
decreases expression |
ISO |
ferric nitrilotriacetate results in decreased expression of SLC11A2 mRNA |
CTD |
PMID:11925462 |
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NCBI chr 7:142,025,812...142,062,892
Ensembl chr 7:142,025,815...142,063,212
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G |
Slc40a1 |
solute carrier family 40 member 1 |
decreases expression |
ISO |
ferric nitrilotriacetate results in decreased expression of SLC40A1 mRNA |
CTD |
PMID:11925462 |
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NCBI chr 9:52,819,451...52,830,461
Ensembl chr 9:52,894,365...52,912,293
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
EXP |
ferric nitrilotriacetate inhibits the reaction [Dimethylnitrosamine results in decreased expression of SOD1 protein] |
CTD |
PMID:15842777 |
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NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
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G |
Ssrp1 |
structure specific recognition protein 1 |
increases expression |
EXP |
ferric nitrilotriacetate results in increased expression of SSRP1 mRNA |
CTD |
PMID:8844983 |
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NCBI chr 3:72,447,516...72,457,621
Ensembl chr 3:72,447,537...72,457,649
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G |
Tgfa |
transforming growth factor alpha |
increases expression |
EXP |
ferric nitrilotriacetate results in increased expression of TGFA mRNA; ferric nitrilotriacetate results in increased expression of TGFA protein |
CTD |
PMID:8340253 |
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NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP |
[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TGFB1 mRNA; CYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TGFB1 mRNA] |
CTD |
PMID:16581302 |
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NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
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G |
Tgfb2 |
transforming growth factor, beta 2 |
increases expression |
EXP |
ferric nitrilotriacetate results in increased expression of TGFB2 mRNA |
CTD |
PMID:23208426 |
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NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
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G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
multiple interactions |
EXP |
[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TIMP1 mRNA; CYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TIMP1 mRNA] |
CTD |
PMID:16581302 |
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NCBI chr X:1,364,771...1,369,451
Ensembl chr X:1,364,786...1,369,384
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G |
Tnf |
tumor necrosis factor |
increases expression multiple interactions |
ISO EXP |
ferric nitrilotriacetate results in increased expression of TNF protein [Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of TNF protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of TNF protein] |
CTD |
PMID:15781289 PMID:23194824 |
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NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
EXP |
[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of TP53 mRNA; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of TP53 protein; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of TP53 mRNA]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of TP53 protein] |
CTD |
PMID:21907755 |
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NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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G |
Txn1 |
thioredoxin 1 |
increases expression |
EXP |
ferric nitrilotriacetate results in increased expression of TXN protein |
CTD |
PMID:15834431 |
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NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
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G |
Txnip |
thioredoxin interacting protein |
decreases expression increases methylation |
EXP |
ferric nitrilotriacetate results in decreased expression of TXNIP protein ferric nitrilotriacetate results in increased methylation of TXNIP promoter |
CTD |
PMID:15834431 |
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NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974
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G |
Ubd |
ubiquitin D |
increases expression |
EXP |
ferric nitrilotriacetate results in increased expression of UBD mRNA |
CTD |
PMID:23208426 |
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NCBI chr20:1,876,175...1,878,126
Ensembl chr20:1,876,173...1,897,814
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
nickel ferrite analog results in increased expression of BAX mRNA; nickel ferrite results in increased expression of BAX mRNA |
CTD |
PMID:21382431 PMID:25966046 |
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NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
nickel ferrite analog results in decreased expression of BCL2 mRNA; nickel ferrite results in decreased expression of BCL2 mRNA |
CTD |
PMID:21382431 PMID:25966046 |
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NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
decreases expression |
ISO |
nickel ferrite results in decreased expression of BIRC5 mRNA |
CTD |
PMID:21382431 |
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NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
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G |
Casp3 |
caspase 3 |
increases activity increases expression |
ISO |
nickel ferrite analog results in increased activity of CASP3 protein; nickel ferrite results in increased activity of CASP3 protein nickel ferrite analog results in increased expression of CASP3 mRNA; nickel ferrite results in increased expression of CASP3 mRNA |
CTD |
PMID:21382431 PMID:25966046 |
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NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Casp9 |
caspase 9 |
increases activity increases expression |
ISO |
nickel ferrite analog results in increased activity of CASP9 protein; nickel ferrite results in increased activity of CASP9 protein nickel ferrite analog results in increased expression of CASP9 mRNA; nickel ferrite results in increased expression of CASP9 mRNA |
CTD |
PMID:21382431 PMID:25966046 |
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NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
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G |
Tp53 |
tumor protein p53 |
increases expression |
ISO |
nickel ferrite analog results in increased expression of TP53 mRNA; nickel ferrite results in increased expression of TP53 mRNA |
CTD |
PMID:21382431 PMID:25966046 |
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NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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