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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:iron(3+)
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Accession:CHEBI:29034 term browser browse the term
Definition:An iron cation that has formula Fe.
Synonyms:exact_synonym: iron(3+) ion;   iron(III) cation
 related_synonym: FE (III) ION;   Fe(3+);   Fe(III);   Fe3+;   Ferric ion;   Formula=Fe;   InChI=1S/Fe/q+3;   InChIKey=VTLYFUHAOXGGBS-UHFFFAOYSA-N;   SMILES=[Fe+3];   ferric iron;   iron, ion (Fe(3+))
 alt_id: CHEBI:13320;   CHEBI:21130;   CHEBI:24877;   CHEBI:34755;   CHEBI:49595
 xref: CAS:20074-52-6;   Gmelin:15986;   KEGG:C14819;   PDBeChem:FE


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ferbam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100125598 metallothionein 1a pseudogene increases expression ISO ferbam results in increased expression of MT1G mRNA CTD PMID:32870474 NCBI chr17:74,786,652...74,787,040
Ensembl chr17:74,786,654...74,787,135 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases activity ISO ferbam results in decreased activity of TGFB1 protein CTD PMID:31652400 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
ferric ammonium citrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aco1 aconitase 1 increases activity
decreases activity		 ISO ferric ammonium citrate results in increased activity of ACO1 protein
ferric ammonium citrate results in decreased activity of ACO1 protein		 CTD PMID:11054110 PMID:18073202 NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391 		JBrowse link
G Aco2 aconitase 2 multiple interactions
increases activity		 ISO ferric ammonium citrate inhibits the reaction [manganese chloride results in decreased activity of ACO2 protein]; ferric ammonium citrate inhibits the reaction [Manganese results in decreased activity of ACO2 protein]
ferric ammonium citrate results in increased activity of ACO2 protein		 CTD PMID:16625280 NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]] CTD PMID:32283200 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin multiple interactions ISO ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of ALB protein] CTD PMID:24862973 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Anxa3 annexin A3 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of ANXA3 protein] CTD PMID:19515424 NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617 		JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of ARHGDIA protein] CTD PMID:19515424 NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023 		JBrowse link
G Bmp6 bone morphogenetic protein 6 multiple interactions ISO ferric ammonium citrate affects the reaction [Deferoxamine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]]; ferric ammonium citrate inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA] CTD PMID:25633564 NCBI chr17:26,318,121...26,469,034
Ensembl chr17:26,318,569...26,470,365 		JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions		 ISO ferric ammonium citrate results in increased cleavage of CASP3 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]; Deferoxamine inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]; DNM1L protein mutant form inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]; N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]		 CTD PMID:17191120 PMID:26318285 PMID:27481217 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO ferric ammonium citrate inhibits the reaction [2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone results in decreased expression of CDKN1A protein] CTD PMID:12807743 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO ferric ammonium citrate results in decreased expression of COL1A1 mRNA CTD PMID:19735707 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Dnm1l dynamin 1-like multiple interactions
decreases phosphorylation		 ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]; Cyclosporine inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]; Deferoxamine inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]; DNM1L protein mutant form inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]; ferric ammonium citrate results in decreased phosphorylation of and affects the localization of DNM1L protein; N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]; Tacrolimus inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein] CTD PMID:26318285 PMID:27481217 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Palmitic Acid results in increased phosphorylation of ERN1 protein] CTD PMID:32283200 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Erp29 endoplasmic reticulum protein 29 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of ERP29 protein] CTD PMID:19515424 NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376 		JBrowse link
G F3 coagulation factor III, tissue factor increases expression
multiple interactions		 ISO ferric ammonium citrate results in increased expression of F3 mRNA
Deferoxamine inhibits the reaction [ferric ammonium citrate results in increased expression of F3 mRNA]		 CTD PMID:25858758 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions ISO ferric ammonium citrate promotes the reaction [Palmitic Acid results in increased expression of FTH1 protein] CTD PMID:32283200 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G Ftl1 ferritin light chain 1 multiple interactions
increases expression		 ISO [ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of FTL mRNA
ferric ammonium citrate results in increased expression of FTL1 mRNA
SLC40A1 protein inhibits the reaction [ferric ammonium citrate results in increased expression of FTL1 mRNA]		 CTD PMID:12393473 PMID:19913091 NCBI chr 1:95,936,390...95,938,234
Ensembl chr 1:95,936,387...95,939,725 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of GAPDH protein] CTD PMID:19515424 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Glo1 glyoxalase 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of GLO1 protein] CTD PMID:19515424 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649 		JBrowse link
G Hamp hepcidin antimicrobial peptide multiple interactions
decreases expression		 ISO Deferoxamine promotes the reaction [ferric ammonium citrate results in decreased expression of HAMP mRNA]; ferric ammonium citrate affects the reaction [Deferoxamine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]]; ferric ammonium citrate inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA] CTD PMID:25633564 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 EXP
ISO		 ferric ammonium citrate results in increased expression of HMOX1 protein
[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of HMOX1 mRNA
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [ferric ammonium citrate results in increased expression of HMOX1 protein]		 CTD PMID:12393473 PMID:16439612 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of HSPA1A protein] CTD PMID:19515424
G Hspa1l heat shock protein family A (Hsp70) member 1 like multiple interactions ISO [ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of HSPA1L mRNA CTD PMID:12393473 NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571 		JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 multiple interactions ISO [ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of HSPA9 mRNA CTD PMID:12393473 NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of HSPD1 protein] CTD PMID:19515424 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of IL1B protein] CTD PMID:24862973 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of IL6 mRNA]; ferric ammonium citrate inhibits the reaction [Ozone results in increased secretion of IL6 protein] CTD PMID:24862973 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]]; ferric ammonium citrate inhibits the reaction [Palmitic Acid inhibits the reaction [INS1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]]; Thapsigargin inhibits the reaction [ferric ammonium citrate inhibits the reaction [Palmitic Acid inhibits the reaction [INS1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]]] CTD PMID:32283200 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Ireb2 iron responsive element binding protein 2 decreases expression
decreases activity		 EXP
ISO		 ferric ammonium citrate results in decreased expression of IREB2 protein
ferric ammonium citrate results in decreased activity of IREB2 protein		 CTD PMID:11054110 PMID:17469137 PMID:18073202 NCBI chr 8:55,228,080...55,311,613
Ensembl chr 8:55,228,085...55,311,611 		JBrowse link
G Lcn2 lipocalin 2 multiple interactions ISO ferric ammonium citrate inhibits the reaction [bathophenanthroline disulfonic acid results in decreased expression of LCN2 protein] CTD PMID:17350462 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO [ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in decreased phosphorylation of MAPK1 protein
ferric ammonium citrate results in increased phosphorylation of MAPK1 protein		 CTD PMID:17191120 PMID:25858758 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases phosphorylation ISO ferric ammonium citrate results in increased phosphorylation of MAPK14 protein CTD PMID:17191120 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO [ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in decreased phosphorylation of MAPK3 protein
ferric ammonium citrate results in increased phosphorylation of MAPK3 protein		 CTD PMID:17191120 PMID:25858758 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mrps9 mitochondrial ribosomal protein S9 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of MRPS9 protein] CTD PMID:19515424 NCBI chr 9:45,113,554...45,172,375
Ensembl chr 9:45,113,554...45,172,375 		JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO [ferric ammonium citrate results in decreased abundance of Iron] which results in increased expression of MT2A mRNA CTD PMID:12393473 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Ncoa4 nuclear receptor coactivator 4 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Palmitic Acid results in increased expression of NCOA4 protein] CTD PMID:32283200 NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,556
Ensembl chr16:7,366,542...7,409,556 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO [ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in increased expression of NOS2 mRNA; Acetylcysteine inhibits the reaction [[ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in increased expression of NOS2 mRNA] CTD PMID:9826428 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Oga O-GlcNAcase multiple interactions ISO ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of OGA protein] CTD PMID:24862973 NCBI chr 1:244,598,285...244,633,835
Ensembl chr 1:244,598,292...244,634,359 		JBrowse link
G P4ha1 prolyl 4-hydroxylase subunit alpha 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of P4HA1 protein] CTD PMID:19515424 NCBI chr20:27,302,046...27,352,098
Ensembl chr20:27,302,141...27,352,786 		JBrowse link
G Pdhb pyruvate dehydrogenase E1 subunit beta multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of PDHB protein] CTD PMID:19515424 NCBI chr15:16,752,561...16,758,503
Ensembl chr15:16,750,980...16,758,500 		JBrowse link
G Pgk1 phosphoglycerate kinase 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of PGK1 protein] CTD PMID:19515424 NCBI chr  X:71,271,454...71,287,429
Ensembl chr  X:71,271,440...71,287,418 		JBrowse link
G Pmp22 peripheral myelin protein 22 multiple interactions ISO [ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of PMP22 mRNA CTD PMID:12393473 NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714 		JBrowse link
G Ppia peptidylprolyl isomerase A multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of PPIA protein] CTD PMID:19515424 NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of PTGS2 mRNA] CTD PMID:24862973 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rack1 receptor for activated C kinase 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of RACK1 protein] CTD PMID:19515424 NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975 		JBrowse link
G Slc11a1 solute carrier family 11 member 1 increases expression ISO ferric ammonium citrate results in increased expression of SLC11A1 mRNA CTD PMID:11054110 NCBI chr 9:75,957,193...75,968,115
Ensembl chr 9:75,957,316...75,968,101 		JBrowse link
G Slc11a2 solute carrier family 11 member 2 increases expression ISO ferric ammonium citrate results in increased expression of SLC11A2 mRNA CTD PMID:11054110 NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145 		JBrowse link
G Slc40a1 solute carrier family 40 member 1 increases expression
multiple interactions		 EXP
ISO		 ferric ammonium citrate results in increased expression of SLC40A1 mRNA
SLC40A1 protein inhibits the reaction [ferric ammonium citrate results in increased expression of FTL1 mRNA]		 CTD PMID:19913091 NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of SOD1 mRNA] CTD PMID:24862973 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Tf transferrin multiple interactions ISO ferric ammonium citrate inhibits the reaction [TF protein results in increased uptake of Iron] CTD PMID:11335103 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511 		JBrowse link
G Tfr2 transferrin receptor 2 decreases expression ISO ferric ammonium citrate results in decreased expression of TFR2 protein CTD PMID:25633564 NCBI chr12:19,107,673...19,124,622
Ensembl chr12:19,107,673...19,124,591 		JBrowse link
G Tfrc transferrin receptor decreases expression
multiple interactions		 ISO ferric ammonium citrate results in decreased expression of TFRC mRNA; ferric ammonium citrate results in decreased expression of TFRC protein
[ferric ammonium citrate results in decreased abundance of Iron] which results in increased expression of TFRC mRNA		 CTD PMID:11054110 PMID:12393473 PMID:16760464 PMID:18073202 PMID:25633564 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of TNF protein] CTD PMID:24862973 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tpd52l1 TPD52 like 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of TPD52L1 protein] CTD PMID:19515424 NCBI chr 1:26,172,038...26,290,704
Ensembl chr 1:26,172,170...26,291,109 		JBrowse link
G Vdac2 voltage-dependent anion channel 2 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of VDAC2 protein] CTD PMID:19515424 NCBI chr15:2,462,877...2,476,802
Ensembl chr15:2,463,056...2,476,553 		JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Palmitic Acid results in increased expression of XBP1 protein] CTD PMID:32283200 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
iron(3+) sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aco1 aconitase 1 multiple interactions ISO ferric sulfate inhibits the reaction [Nickel results in increased activity of ACO1 protein] CTD PMID:16877034 NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions
increases activity		 EXP Capsaicin inhibits the reaction [ferric sulfate results in increased activity of GOT1 protein]; Curcumin inhibits the reaction [ferric sulfate results in increased activity of GOT1 protein] CTD PMID:16956363 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases activity		 EXP Capsaicin inhibits the reaction [ferric sulfate results in increased activity of GPT protein]; Curcumin inhibits the reaction [ferric sulfate results in increased activity of GPT protein] CTD PMID:16956363 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO ferric sulfate inhibits the reaction [Nickel results in increased stability of HIF1A protein] CTD PMID:16877034 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
iron(III) citrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin increases secretion
multiple interactions
increases expression		 ISO ferric citrate results in increased secretion of ALB protein
Alcohols inhibits the reaction [ferric citrate results in increased expression of ALB mRNA]; Alcohols inhibits the reaction [ferric citrate results in increased secretion of ALB protein]; ferric citrate inhibits the reaction [Alcohols results in increased expression of ALB mRNA]; ferric citrate inhibits the reaction [Alcohols results in increased secretion of ALB protein]		 CTD PMID:24025710 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Aldob aldolase, fructose-bisphosphate B increases expression
multiple interactions		 ISO ferric citrate results in increased expression of ALDOB mRNA
Alcohols inhibits the reaction [ferric citrate results in increased expression of ALDOB mRNA]; ferric citrate inhibits the reaction [Alcohols results in increased expression of ALDOB mRNA]		 CTD PMID:24025710 NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116 		JBrowse link
G Aqp4 aquaporin 4 decreases expression ISO ferric citrate results in decreased expression of AQP4 mRNA CTD PMID:29959986 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856 		JBrowse link
G Ca9 carbonic anhydrase 9 decreases expression ISO ferric citrate results in decreased expression of CA9 mRNA CTD PMID:29959986 NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO ferric citrate results in decreased expression of CCL2 mRNA CTD PMID:29959986 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cftr CF transmembrane conductance regulator decreases expression ISO ferric citrate results in decreased expression of CFTR mRNA CTD PMID:29959986 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Crp C-reactive protein increases expression ISO ferric citrate results in increased expression of CRP mRNA CTD PMID:29959986 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases expression		 ISO Alcohols inhibits the reaction [ferric citrate results in increased expression of CYP2E1 mRNA]; ferric citrate inhibits the reaction [Alcohols results in increased expression of CYP2E1 mRNA] CTD PMID:24025710 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions		 ISO ferric citrate results in increased expression of CYP3A4 mRNA; ferric citrate results in increased expression of CYP3A4 protein
Alcohols inhibits the reaction [ferric citrate results in increased expression of CYP3A4 mRNA]; Alcohols promotes the reaction [ferric citrate results in increased expression of CYP3A4 protein]; ferric citrate inhibits the reaction [Alcohols results in increased expression of CYP3A4 mRNA]; ferric citrate promotes the reaction [Alcohols results in increased expression of CYP3A4 protein]		 CTD PMID:24025710 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO [trigonelline co-treated with ferric citrate] results in increased expression of DDIT3 mRNA CTD PMID:29959986 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Edn1 endothelin 1 decreases expression ISO ferric citrate results in decreased expression of EDN1 mRNA CTD PMID:29959986 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Epo erythropoietin increases expression ISO ferric citrate results in increased expression of EPO mRNA CTD PMID:29959986 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G F10 coagulation factor X decreases activity ISO ferric citrate results in decreased activity of F10 protein CTD PMID:6421970 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141 		JBrowse link
G F2 coagulation factor II decreases activity ISO ferric citrate results in decreased activity of F2 protein CTD PMID:6421970 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G Fth1 ferritin heavy chain 1 increases expression
multiple interactions		 ISO ferric citrate results in increased expression of FTH1 mRNA
[trigonelline co-treated with ferric citrate] results in increased expression of FTH1 mRNA		 CTD PMID:29959986 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G Ftl1 ferritin light chain 1 multiple interactions ISO [trigonelline co-treated with ferric citrate] results in increased expression of FTL mRNA CTD PMID:29959986 NCBI chr 1:95,936,390...95,938,234
Ensembl chr 1:95,936,387...95,939,725 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO ferric citrate results in increased expression of GCLM mRNA CTD PMID:29959986 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO ferric citrate inhibits the reaction [Deferoxamine results in increased expression of HIF1A protein]
ferric citrate inhibits the reaction [Deferoxamine results in increased expression of HIF1A protein]; ferric citrate inhibits the reaction [Quercetin results in increased expression of HIF1A mRNA]; ferric citrate inhibits the reaction [Quercetin results in increased expression of HIF1A protein]		 CTD PMID:16527254 PMID:17015263 PMID:17364964 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO ferric citrate results in increased expression of HMOX1 mRNA CTD PMID:29959986 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO ferric citrate results in decreased expression of IL1A mRNA CTD PMID:29959986 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO [trigonelline co-treated with ferric citrate] results in decreased expression of KEAP1 mRNA CTD PMID:29959986 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Klk1 kallikrein 1 decreases activity ISO ferric citrate results in decreased activity of KLK1 protein CTD PMID:6421970 NCBI chr 1:94,642,722...94,646,714
Ensembl chr 1:94,642,687...94,646,754 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization
multiple interactions		 ISO ferric citrate affects the localization of NFE2L2 protein
trigonelline inhibits the reaction [ferric citrate affects the localization of NFE2L2 protein]		 CTD PMID:29959986 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions		 ISO ferric citrate results in increased expression of NQO1 mRNA; ferric citrate results in increased expression of NQO1 protein
trigonelline inhibits the reaction [ferric citrate results in increased expression of NQO1 protein]		 CTD PMID:29959986 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO ferric citrate inhibits the reaction [Deferoxamine results in increased expression of PTGS2 protein] CTD PMID:16527254 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Serpine1 serpin family E member 1 decreases expression ISO ferric citrate results in decreased expression of SERPINE1 mRNA CTD PMID:29959986 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO ferric citrate results in increased expression of SQSTM1 mRNA CTD PMID:29959986 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Tf transferrin increases expression ISO ferric citrate results in increased expression of TF mRNA CTD PMID:24025710 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511 		JBrowse link
G Tfrc transferrin receptor increases expression
multiple interactions		 ISO ferric citrate results in increased expression of TFRC protein
ferric citrate inhibits the reaction [Quercetin results in increased expression of TFRC protein]		 CTD PMID:17364964 PMID:29959986 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tnf tumor necrosis factor decreases expression ISO ferric citrate results in decreased expression of TNF mRNA CTD PMID:29959986 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO ferric citrate results in increased expression of TXNRD1 mRNA CTD PMID:29959986 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
iron(III) nitrilotriacetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO ferric nitrilotriacetate inhibits the reaction [Asbestos, Crocidolite results in increased expression of ABCB1 protein]; ferric nitrilotriacetate inhibits the reaction [Razoxane results in increased expression of ABCB1 protein] CTD PMID:18385176 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression ISO ferric nitrilotriacetate results in increased expression of ABCC1 mRNA CTD PMID:18617210 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO ferric nitrilotriacetate results in increased expression of ABCC2 mRNA CTD PMID:18617210 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases expression ISO ferric nitrilotriacetate results in increased expression of ABCC4 mRNA CTD PMID:18617210 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Anxa2 annexin A2 increases expression EXP ferric nitrilotriacetate results in increased expression of ANXA2 mRNA CTD PMID:10854235 NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP ferric nitrilotriacetate results in increased expression of BAX mRNA CTD PMID:23208426 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression EXP ferric nitrilotriacetate results in increased expression of BBC3 mRNA CTD PMID:23208426 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bik BCL2-interacting killer increases expression EXP ferric nitrilotriacetate results in increased expression of BIK mRNA CTD PMID:23208426 NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296 		JBrowse link
G Cald1 caldesmon 1 increases expression EXP ferric nitrilotriacetate results in increased expression of CALD1 mRNA CTD PMID:10854235 NCBI chr 4:63,265,781...63,446,936
Ensembl chr 4:63,265,942...63,446,932 		JBrowse link
G Canx calnexin increases expression EXP ferric nitrilotriacetate results in increased expression of CANX protein CTD PMID:16908007 NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821 		JBrowse link
G Casp12 caspase 12 increases expression EXP ferric nitrilotriacetate results in increased expression of CASP12 mRNA CTD PMID:23208426 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP3 protein; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP3 mRNA; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP3 protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP3 mRNA] CTD PMID:21907755 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions EXP [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP8 protein; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP8 mRNA; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP8 protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP8 mRNA] CTD PMID:21907755 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP9 protein; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP9 mRNA; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP9 protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP9 mRNA] CTD PMID:21907755 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions
decreases activity		 EXP [Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of CAT protein; chrysin inhibits the reaction [ferric nitrilotriacetate results in decreased activity of CAT protein]; geraniol inhibits the reaction [ferric nitrilotriacetate results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of CAT protein]; Quercetin inhibits the reaction [ferric nitrilotriacetate results in decreased activity of CAT protein] CTD PMID:9667754 PMID:15198074 PMID:18684806 PMID:21907755 PMID:23194824 More... NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnd1 cyclin D1 increases expression EXP ferric nitrilotriacetate results in increased expression of CCND1 mRNA; ferric nitrilotriacetate results in increased expression of CCND1 protein CTD PMID:18055543 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression EXP ferric nitrilotriacetate results in increased expression of CD44 mRNA; ferric nitrilotriacetate results in increased expression of CD44 protein CTD PMID:18055543 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cd47 Cd47 molecule increases expression EXP ferric nitrilotriacetate results in increased expression of CD47 mRNA CTD PMID:9119739 NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP ferric nitrilotriacetate results in increased expression of CDKN1A mRNA CTD PMID:23208426 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 decreases expression EXP ferric nitrilotriacetate results in decreased expression of CHRM1 mRNA CTD PMID:19490752 NCBI chr 1:205,567,046...205,583,001
Ensembl chr 1:205,567,220...205,582,356 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 decreases expression EXP ferric nitrilotriacetate results in decreased expression of CHRM2 mRNA CTD PMID:19490752 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103 		JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression
multiple interactions		 EXP ferric nitrilotriacetate results in increased expression of COL1A1 protein
ethylisopropylamiloride inhibits the reaction [ferric nitrilotriacetate results in increased expression of COL1A1 protein]		 CTD PMID:11159895 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Cygb cytoglobin multiple interactions EXP CYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TGFB1 mRNA]; CYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TIMP1 mRNA]; CYGB protein results in decreased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid] CTD PMID:16581302 NCBI chr10:101,877,675...101,887,442
Ensembl chr10:101,877,676...101,887,442 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT18 protein; [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT8 protein; [Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein; allyl sulfide inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]]; CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]; Ditiocarb inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]] CTD PMID:12086689 PMID:17034788 PMID:21352821 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO ferric nitrilotriacetate results in increased expression of FOS mRNA CTD PMID:10381381 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression EXP ferric nitrilotriacetate results in increased expression of FOSL1 mRNA; ferric nitrilotriacetate results in increased expression of FOSL1 protein CTD PMID:18055543 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity EXP ferric nitrilotriacetate results in decreased activity of G6PD protein CTD PMID:9667754 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO ferric nitrilotriacetate results in increased expression of GCLC mRNA CTD PMID:18617210 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gsr glutathione-disulfide reductase decreases activity
multiple interactions		 EXP ferric nitrilotriacetate results in decreased activity of GSR protein
[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of GSR protein; Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of GSR protein]; Quercetin inhibits the reaction [ferric nitrilotriacetate results in decreased activity of GSR protein]		 CTD PMID:9667754 PMID:15198074 PMID:30098279 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gtse1 G-2 and S-phase expressed 1 increases expression EXP ferric nitrilotriacetate results in increased expression of GTSE1 mRNA CTD PMID:23208426 NCBI chr 7:116,949,997...116,966,826
Ensembl chr 7:116,950,053...116,966,806 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP [Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased secretion of HAVCR1 protein; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of HAVCR1 mRNA; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of HAVCR1 protein; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of HAVCR1 mRNA]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of HAVCR1 protein]; Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased secretion of HAVCR1 protein] CTD PMID:21907755 PMID:30098279 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO ferric nitrilotriacetate inhibits the reaction [Asbestos, Crocidolite results in increased activity of HIF1A protein]; ferric nitrilotriacetate inhibits the reaction [Razoxane results in increased activity of HIF1A protein] CTD PMID:18385176 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP
ISO		 ferric nitrilotriacetate results in increased expression of HMOX1 mRNA CTD PMID:18617210 PMID:19490752 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression EXP ferric nitrilotriacetate results in increased expression of HSP90AA1 mRNA CTD PMID:10854235 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268 		JBrowse link
G Il24 interleukin 24 increases expression EXP ferric nitrilotriacetate results in increased expression of IL24 mRNA CTD PMID:23208426 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 ISO
EXP		 ferric nitrilotriacetate results in increased expression of IL6 protein
ferric nitrilotriacetate results in increased expression of IL6 mRNA
[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of IL6 protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of IL6 protein]		 CTD PMID:15781289 PMID:19490752 PMID:23194824 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP ferric nitrilotriacetate results in increased expression of JUN mRNA; ferric nitrilotriacetate results in increased expression of JUN protein CTD PMID:18055543 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Krt18 keratin 18 multiple interactions ISO [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT18 protein CTD PMID:17034788 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166 		JBrowse link
G Krt8 keratin 8 multiple interactions ISO [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT8 protein CTD PMID:17034788 NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression EXP ferric nitrilotriacetate results in increased expression of MCM3 mRNA CTD PMID:23208426 NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314 		JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO [ferric nitrilotriacetate co-treated with Hydrogen Peroxide] inhibits the reaction [MT1 protein binds to Cadmium]; [ferric nitrilotriacetate co-treated with Hydrogen Peroxide] inhibits the reaction [MT1 protein binds to Zinc]; ferric nitrilotriacetate results in increased oxidation of [MT1 protein binds to Zinc] CTD PMID:22001350 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 		JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO [ferric nitrilotriacetate co-treated with Hydrogen Peroxide] inhibits the reaction [MT2 protein binds to Cadmium] CTD PMID:22001350 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Mt3 metallothionein 3 decreases response to substance ISO MT3 protein results in decreased susceptibility to ferric nitrilotriacetate CTD PMID:12383939 NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression EXP ferric nitrilotriacetate results in increased expression of MYC mRNA; ferric nitrilotriacetate results in increased expression of MYC protein CTD PMID:18055543 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization ISO ferric nitrilotriacetate affects the localization of NFE2L2 protein CTD PMID:18617210 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of NFKB1 mRNA; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of NFKB1 mRNA] CTD PMID:21907755 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression		 ISO
EXP		 ferric nitrilotriacetate inhibits the reaction [Doxorubicin results in increased expression of NOS2 mRNA]; ferric nitrilotriacetate inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein]; ferric nitrilotriacetate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
ferric nitrilotriacetate results in increased expression of NOS2 protein
[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of NOS2 protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of NOS2 protein]; chrysin inhibits the reaction [ferric nitrilotriacetate results in increased expression of NOS2 protein]; ferric nitrilotriacetate promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; ferric nitrilotriacetate promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]		 CTD PMID:11461780 PMID:11746204 PMID:12490132 PMID:23194824 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO ferric nitrilotriacetate results in increased expression of NQO1 mRNA; ferric nitrilotriacetate results in increased expression of NQO1 protein CTD PMID:18617210 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions
increases activity		 EXP [ferric nitrilotriacetate results in increased abundance of Hydroxyl Radical] which results in increased activity of ODC1 protein; Active Hexose Correlated Compound inhibits the reaction [[ferric nitrilotriacetate results in increased abundance of Hydroxyl Radical] which results in increased activity of ODC1 protein]; Vitamin E inhibits the reaction [ferric nitrilotriacetate results in increased activity of ODC1 protein] CTD PMID:9667754 PMID:14623030 PMID:15949125 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression EXP ferric nitrilotriacetate results in increased expression of PCK1 mRNA CTD PMID:16960379 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP [Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PCNA protein; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of PCNA mRNA; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of PCNA protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PCNA protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of PCNA mRNA]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of PCNA protein] CTD PMID:21907755 PMID:23194824 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 increases expression EXP ferric nitrilotriacetate results in increased expression of PHLDA3 mRNA CTD PMID:23208426 NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335 		JBrowse link
G Plau plasminogen activator, urokinase multiple interactions
increases expression
increases activity		 ISO Deferoxamine inhibits the reaction [ferric nitrilotriacetate results in increased activity of PLAU mRNA]; Deferoxamine inhibits the reaction [ferric nitrilotriacetate results in increased expression of PLAU mRNA] CTD PMID:17571974 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Plk2 polo-like kinase 2 increases expression EXP ferric nitrilotriacetate results in increased expression of PLK2 mRNA CTD PMID:23208426 NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947 		JBrowse link
G Pola1 DNA polymerase alpha 1, catalytic subunit increases expression EXP ferric nitrilotriacetate results in increased expression of POLA1 mRNA CTD PMID:10854235 NCBI chr  X:58,034,617...58,348,612
Ensembl chr  X:58,034,619...58,348,536 		JBrowse link
G Ppia peptidylprolyl isomerase A increases expression EXP ferric nitrilotriacetate results in increased expression of PPIA protein CTD PMID:16908007 NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 EXP [Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PTGS2 protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PTGS2 protein]; chrysin inhibits the reaction [ferric nitrilotriacetate results in increased expression of PTGS2 protein]; Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PTGS2 protein] CTD PMID:23194824 PMID:30098279 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptprb protein tyrosine phosphatase, receptor type, B decreases expression EXP ferric nitrilotriacetate results in decreased expression of PTPRB mRNA CTD PMID:10854235 NCBI chr 7:51,953,375...52,034,751
Ensembl chr 7:51,930,015...52,034,748 		JBrowse link
G Ptprz1 protein tyrosine phosphatase, receptor type Z1 increases expression EXP ferric nitrilotriacetate results in increased expression of PTPRZ1 mRNA; ferric nitrilotriacetate results in increased expression of PTPRZ1 protein CTD PMID:18055543 NCBI chr 4:51,397,316...51,595,220
Ensembl chr 4:51,397,601...51,595,218 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP [Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased localization of RELA protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased localization of RELA protein] CTD PMID:23194824 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rpl19 ribosomal protein L19 increases expression EXP ferric nitrilotriacetate results in increased expression of RPL19 mRNA CTD PMID:10854235 NCBI chr10:83,022,503...83,026,030
Ensembl chr10:83,019,257...83,052,112 		JBrowse link
G Rprm reprimo, TP53 dependent G2 arrest mediator homolog increases expression EXP ferric nitrilotriacetate results in increased expression of RPRM mRNA CTD PMID:23208426 NCBI chr 3:38,539,581...38,540,998
Ensembl chr 3:38,539,581...38,540,998 		JBrowse link
G Rps13 ribosomal protein S13 increases expression EXP ferric nitrilotriacetate results in increased expression of RPS13 mRNA CTD PMID:10854235 NCBI chr 1:170,572,925...170,575,355
Ensembl chr 1:170,572,921...170,575,355 		JBrowse link
G Rps15 ribosomal protein S15 increases expression EXP ferric nitrilotriacetate results in increased expression of RPS15 mRNA CTD PMID:10854235 NCBI chr 7:9,416,003...9,417,442
Ensembl chr 7:9,416,004...9,417,450 		JBrowse link
G Slc11a2 solute carrier family 11 member 2 decreases expression ISO ferric nitrilotriacetate results in decreased expression of SLC11A2 mRNA CTD PMID:11925462 NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145 		JBrowse link
G Slc40a1 solute carrier family 40 member 1 decreases expression ISO ferric nitrilotriacetate results in decreased expression of SLC40A1 mRNA CTD PMID:11925462 NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP ferric nitrilotriacetate inhibits the reaction [Dimethylnitrosamine results in decreased expression of SOD1 protein] CTD PMID:15842777 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Ssrp1 structure specific recognition protein 1 increases expression EXP ferric nitrilotriacetate results in increased expression of SSRP1 mRNA CTD PMID:8844983 NCBI chr 3:70,124,371...70,134,481
Ensembl chr 3:70,118,655...70,134,482 		JBrowse link
G Tgfa transforming growth factor alpha increases expression EXP ferric nitrilotriacetate results in increased expression of TGFA mRNA; ferric nitrilotriacetate results in increased expression of TGFA protein CTD PMID:8340253 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TGFB1 mRNA; CYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TGFB1 mRNA] CTD PMID:16581302 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression EXP ferric nitrilotriacetate results in increased expression of TGFB2 mRNA CTD PMID:23208426 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP [ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TIMP1 mRNA; CYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TIMP1 mRNA] CTD PMID:16581302 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 ISO
EXP		 ferric nitrilotriacetate results in increased expression of TNF protein
[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of TNF protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of TNF protein]		 CTD PMID:15781289 PMID:23194824 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of TP53 mRNA; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of TP53 protein; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of TP53 mRNA]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of TP53 protein] CTD PMID:21907755 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Txn1 thioredoxin 1 increases expression EXP ferric nitrilotriacetate results in increased expression of TXN protein CTD PMID:15834431 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
G Txnip thioredoxin interacting protein decreases expression
increases methylation		 EXP ferric nitrilotriacetate results in decreased expression of TXNIP protein
ferric nitrilotriacetate results in increased methylation of TXNIP promoter		 CTD PMID:15834431 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886 		JBrowse link
G Ubd ubiquitin D increases expression EXP ferric nitrilotriacetate results in increased expression of UBD mRNA CTD PMID:23208426 NCBI chr20:1,385,487...1,387,438
Ensembl chr20:1,383,424...1,389,406
Ensembl chr20:1,383,424...1,389,406 		JBrowse link
nickel ferrite term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO nickel ferrite analog results in increased expression of BAX mRNA; nickel ferrite results in increased expression of BAX mRNA CTD PMID:21382431 PMID:25966046 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO nickel ferrite analog results in decreased expression of BCL2 mRNA; nickel ferrite results in decreased expression of BCL2 mRNA CTD PMID:21382431 PMID:25966046 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO nickel ferrite results in decreased expression of BIRC5 mRNA CTD PMID:21382431 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Casp3 caspase 3 increases activity
increases expression		 ISO nickel ferrite analog results in increased activity of CASP3 protein; nickel ferrite results in increased activity of CASP3 protein
nickel ferrite analog results in increased expression of CASP3 mRNA; nickel ferrite results in increased expression of CASP3 mRNA		 CTD PMID:21382431 PMID:25966046 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases activity
increases expression		 ISO nickel ferrite analog results in increased activity of CASP9 protein; nickel ferrite results in increased activity of CASP9 protein
nickel ferrite analog results in increased expression of CASP9 mRNA; nickel ferrite results in increased expression of CASP9 mRNA		 CTD PMID:21382431 PMID:25966046 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO nickel ferrite analog results in increased expression of TP53 mRNA; nickel ferrite results in increased expression of TP53 mRNA CTD PMID:21382431 PMID:25966046 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    role 20009
      biological role 20008
        biochemical role 19630
          cofactor 15868
            iron(3+) 143
              ferbam 2
              ferric ammonium citrate 55
              ferric yersiniabactin 0
              ferrioxamine B 0
              ferrioxamine E 0
              iron(3+) phosphate + 0
              iron(3+) sulfate + 4
              iron(3+) sulfides + 0
              iron(III) citrate + 31
              iron(III) nitrilotriacetate 77
              iron(III) vibrioferrin 0
              nickel ferrite 6
              nickel-zinc ferrite 0
              sodium feredetate 0
              zinc ferrite 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  metal atom 17548
                    transition element atom 16960
                      d-block element atom 16951
                        iron group element atom 881
                          iron atom 859
                            iron molecular entity 859
                              elemental iron 509
                                iron cation 207
                                  iron(3+) 143
                                    ferbam 2
                                    ferric ammonium citrate 55
                                    ferric yersiniabactin 0
                                    ferrioxamine B 0
                                    ferrioxamine E 0
                                    iron(3+) phosphate + 0
                                    iron(3+) sulfate + 4
                                    iron(3+) sulfides + 0
                                    iron(III) citrate + 31
                                    iron(III) nitrilotriacetate 77
                                    iron(III) vibrioferrin 0
                                    nickel ferrite 6
                                    nickel-zinc ferrite 0
                                    sodium feredetate 0
                                    zinc ferrite 0
paths to the root