CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: hexane
Accession: CHEBI:29021
browse the term
Definition: An unbranched alkane containing six carbon atoms.
Synonyms: related_synonym: CH3-[CH2]4-CH3; Formula=C6H14; Hexan; InChI=1S/C6H14/c1-3-5-6-4-2/h3-6H2,1-2H3; InChIKey=VLKZOEOYAKHREP-UHFFFAOYSA-N; SMILES=CCCCCC; n-Hexane
alt_id: CHEBI:10606; CHEBI:24566; CHEBI:24568; CHEBI:43148
xref: Beilstein:1730733; CAS:110-54-3; DrugBank:DB02764; Gmelin:1985; HMDB:HMDB0029600; KEGG:C11271; LIPID_MAPS_instance:LMFA11000007
xref_mesh: MESH:C026385
xref: PDBeChem:HEX; PMID:11292478; PMID:11684179; PMID:11886809; PMID:15325316; PMID:18231777; PMID:19229957; PMID:19384711; PMID:23452516; PMID:23567114; PMID:23620851; PMID:23740543; PMID:23822317; PMID:23931182; PMID:7612176; Reaxys:1730733; Wikipedia:Hexane
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Adrb1
adrenoceptor beta 1
multiple interactions
ISO
[Particulate Matter co-treated with n-hexane] results in decreased expression of ADRB1 mRNA
CTD
PMID:30503853
NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
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Adrb2
adrenoceptor beta 2
multiple interactions
ISO
[Particulate Matter co-treated with n-hexane] results in decreased expression of ADRB2 mRNA
CTD
PMID:30503853
NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
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Akr1b1
aldo-keto reductase family 1 member B
increases expression
ISO
n-hexane results in increased expression of AKR1B1 mRNA
CTD
PMID:20566472
NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
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Akr1b10
aldo-keto reductase family 1 member B10
increases expression
ISO
n-hexane results in increased expression of AKR1B10 mRNA
CTD
PMID:20566472
NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
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Akr1c3
aldo-keto reductase family 1, member C3
increases expression
ISO
n-hexane results in increased expression of AKR1C3 mRNA
CTD
PMID:20566472
NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
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Alpl
alkaline phosphatase, biomineralization associated
decreases methylation
EXP
n-hexane results in decreased methylation of ALPL promoter
CTD
PMID:23740543
NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
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Areg
amphiregulin
decreases methylation
EXP
n-hexane results in decreased methylation of AREG promoter
CTD
PMID:23740543
NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
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Arhgap45
Rho GTPase activating protein 45
increases methylation
EXP
n-hexane results in increased methylation of ARHGAP45 promoter
CTD
PMID:23740543
NCBI chr 7:12,541,032...12,741,314
Ensembl chr 7:12,541,061...12,741,296
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Atl2
atlastin GTPase 2
decreases methylation
EXP
n-hexane results in decreased methylation of ATL2 promoter
CTD
PMID:23740543
NCBI chr 6:2,568,975...2,610,432
Ensembl chr 6:2,568,990...2,610,437
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Bax
BCL2 associated X, apoptosis regulator
increases expression
EXP
n-hexane metabolite results in increased expression of BAX protein
CTD
PMID:17492505
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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Bcl2
BCL2, apoptosis regulator
increases expression
EXP
n-hexane metabolite results in increased expression of BCL2 protein
CTD
PMID:17492505
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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Bclaf1
BCL2-associated transcription factor 1
decreases methylation
EXP
n-hexane results in decreased methylation of BCLAF1 promoter
CTD
PMID:23740543
NCBI chr 1:15,799,753...15,828,838
Ensembl chr 1:15,782,477...15,860,624
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Calr3
calreticulin 3
increases methylation
EXP
n-hexane results in increased methylation of CALR3 promoter
CTD
PMID:23740543
NCBI chr16:19,097,391...19,124,062
Ensembl chr16:19,097,391...19,124,062
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Cap1
cyclase associated actin cytoskeleton regulatory protein 1
decreases methylation
EXP
n-hexane results in decreased methylation of CAP1 promoter
CTD
PMID:23740543
NCBI chr 5:140,559,195...140,585,494
Ensembl chr 5:140,559,206...140,585,408
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Casp3
caspase 3
increases expression
EXP
n-hexane metabolite results in increased expression of CASP3 protein
CTD
PMID:17492505
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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Ccnk
cyclin K
decreases methylation
EXP
n-hexane results in decreased methylation of CCNK promoter
CTD
PMID:23740543
NCBI chr 6:132,090,235...132,113,560
Ensembl chr 6:132,090,218...132,113,557
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Cfap20
cilia and flagella associated protein 20
decreases methylation
EXP
n-hexane results in decreased methylation of CFAP20 promoter
CTD
PMID:23740543
NCBI chr19:10,024,938...10,038,838
Ensembl chr19:10,024,947...10,038,784
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Chic2
cysteine-rich hydrophobic domain 2
decreases methylation
EXP
n-hexane results in decreased methylation of CHIC2 promoter
CTD
PMID:23740543
NCBI chr14:35,683,657...35,718,005
Ensembl chr14:35,683,442...35,717,922
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Chmp2a
charged multivesicular body protein 2A
decreases methylation
EXP
n-hexane results in decreased methylation of CHMP2A promoter
CTD
PMID:23740543
NCBI chr 1:65,540,808...65,543,708
Ensembl chr 1:65,541,322...65,543,707
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Clcn2
chloride voltage-gated channel 2
decreases methylation
EXP
n-hexane results in decreased methylation of CLCN2 promoter
CTD
PMID:23740543
NCBI chr11:82,862,664...82,876,165
Ensembl chr11:83,883,879...83,897,394
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Coprs
coordinator of PRMT5 and differentiation stimulator
decreases methylation
EXP
n-hexane results in decreased methylation of COPRS promoter
CTD
PMID:23740543
NCBI chr16:80,826,681...80,831,791
Ensembl chr16:80,826,681...80,831,791
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Copz2
COPI coat complex subunit zeta 2
decreases methylation
EXP
n-hexane results in decreased methylation of COPZ2 promoter
CTD
PMID:23740543
NCBI chr10:84,718,824...84,731,880
Ensembl chr10:84,718,824...84,731,880
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Crppa
CDP-L-ribitol pyrophosphorylase A
decreases methylation
EXP
n-hexane results in decreased methylation of CRPPA promoter
CTD
PMID:23740543
NCBI chr 6:55,880,136...56,159,466
Ensembl chr 6:55,881,387...56,159,464
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Cspg4
chondroitin sulfate proteoglycan 4
increases methylation
EXP
n-hexane results in increased methylation of CSPG4 promoter
CTD
PMID:23740543
NCBI chr 8:61,532,465...61,567,510
Ensembl chr 8:61,532,465...61,567,510
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Cthrc1
collagen triple helix repeat containing 1
decreases methylation
EXP
n-hexane results in decreased methylation of CTHRC1 promoter
CTD
PMID:23740543
NCBI chr 7:77,966,722...77,977,004
Ensembl chr 7:77,966,722...77,977,004
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Cul4a
cullin 4A
decreases methylation
EXP
n-hexane results in decreased methylation of CUL4A promoter
CTD
PMID:23740543
NCBI chr16:81,718,784...81,756,653
Ensembl chr16:81,719,028...81,756,654
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Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
affects expression affects methylation
EXP
n-hexane affects the expression of CYP11A1 mRNA; n-hexane affects the expression of CYP11A1 protein n-hexane affects the methylation of CYP11A1 promoter
CTD
PMID:26410608
NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
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Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
affects expression affects methylation
EXP
n-hexane affects the expression of CYP17A1 mRNA; n-hexane affects the expression of CYP17A1 protein n-hexane affects the methylation of CYP17A1 promoter
CTD
PMID:26410608
NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases hydroxylation multiple interactions
EXP
CYP1A1 protein results in increased hydroxylation of n-hexane diallyl trisulfide promotes the reaction [n-hexane results in increased expression of and results in increased activity of CYP1A1 protein]; n-hexane results in increased expression of and results in increased activity of CYP1A1 protein
CTD
PMID:16484137 PMID:28115069
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases hydroxylation multiple interactions
EXP
CYP1A2 protein results in increased hydroxylation of n-hexane diallyl trisulfide inhibits the reaction [n-hexane results in increased expression of CYP1A2 protein]; n-hexane results in increased expression of and results in increased activity of CYP1A2 protein
CTD
PMID:16484137 PMID:28115069
NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
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Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
multiple interactions increases activity
EXP
diallyl trisulfide inhibits the reaction [n-hexane results in increased activity of CYP2B1 protein]
CTD
PMID:28115069
NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
increases hydroxylation
ISO
CYP2B1 protein results in increased hydroxylation of n-hexane; CYP2B6 protein results in increased hydroxylation of n-hexane
CTD
PMID:16484137
NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
affects response to substance multiple interactions increases metabolic processing increases hydroxylation
ISO EXP
CYP2E1 gene polymorphism affects the susceptibility to n-hexane diallyl trisulfide inhibits the reaction [n-hexane results in increased expression of and results in increased activity of CYP2E1 protein]; n-hexane results in increased expression of and results in increased activity of CYP2E1 protein CYP2E1 protein results in increased metabolism of n-hexane CYP2E1 protein results in increased hydroxylation of n-hexane
CTD
PMID:11201664 PMID:16484137 PMID:28115069
NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
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Dip2c
disco-interacting protein 2 homolog C
decreases methylation
EXP
n-hexane results in decreased methylation of DIP2C promoter
CTD
PMID:23740543
NCBI chr17:63,426,688...63,810,183
Ensembl chr17:63,635,086...63,808,464
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Dnmt1
DNA methyltransferase 1
decreases methylation
EXP
n-hexane results in decreased methylation of DNMT1 promoter
CTD
PMID:23740543
NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
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Dnmt3a
DNA methyltransferase 3 alpha
decreases methylation
EXP
n-hexane results in decreased methylation of DNMT3A promoter
CTD
PMID:23740543
NCBI chr 6:28,205,375...28,346,052
Ensembl chr 6:28,235,695...28,340,577
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Dnttip1
deoxynucleotidyltransferase, terminal, interacting protein 1
decreases methylation
EXP
n-hexane results in decreased methylation of DNTTIP1 promoter
CTD
PMID:23740543
NCBI chr 3:161,212,156...161,235,749
Ensembl chr 3:161,212,156...161,236,121
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Drd5
dopamine receptor D5
decreases methylation
EXP
n-hexane results in decreased methylation of DRD5 promoter
CTD
PMID:23740543
NCBI chr14:77,220,579...77,222,006
Ensembl chr14:77,220,579...77,222,006
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E2f3
E2F transcription factor 3
decreases methylation
EXP
n-hexane results in decreased methylation of E2F3 promoter
CTD
PMID:23740543
NCBI chr17:36,334,136...36,408,831
Ensembl chr17:36,334,147...36,408,831
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Epn3
epsin 3
decreases methylation
EXP
n-hexane results in decreased methylation of EPN3 promoter
CTD
PMID:23740543
NCBI chr10:82,220,762...82,231,200
Ensembl chr10:82,220,762...82,229,140
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Fam20a
FAM20A, golgi associated secretory pathway pseudokinase
increases methylation
EXP
n-hexane results in increased methylation of FAM20A promoter
CTD
PMID:23740543
NCBI chr10:97,962,467...98,017,171
Ensembl chr10:97,962,693...98,018,014
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Fech
ferrochelatase
increases expression
ISO
n-hexane results in increased expression of FECH mRNA
CTD
PMID:20566472
NCBI chr18:59,941,992...59,975,192
Ensembl chr18:59,941,992...59,975,192
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Fgfbp1
fibroblast growth factor binding protein 1
decreases methylation
EXP
n-hexane results in decreased methylation of FGFBP1 promoter
CTD
PMID:23740543
NCBI chr14:71,647,429...71,650,359
Ensembl chr14:71,649,274...71,650,354
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Fjx1
four-jointed box kinase 1
decreases methylation
EXP
n-hexane results in decreased methylation of FJX1 promoter
CTD
PMID:23740543
NCBI chr 3:92,288,818...92,290,919
Ensembl chr 3:92,288,818...92,290,919
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Fmo3
flavin containing dimethylaniline monoxygenase 3
decreases methylation
EXP
n-hexane results in decreased methylation of FMO3 promoter
CTD
PMID:23740543
NCBI chr13:80,837,418...80,856,214
Ensembl chr13:80,837,420...80,862,963
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Foxi1
forkhead box I1
decreases methylation
EXP
n-hexane results in decreased methylation of FOXI1 promoter
CTD
PMID:23740543
NCBI chr10:19,160,566...19,164,505
Ensembl chr10:19,160,582...19,164,505
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Ftl1
ferritin light chain 1
increases expression
ISO
n-hexane results in increased expression of FTL mRNA
CTD
PMID:20566472
NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
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G6pd
glucose-6-phosphate dehydrogenase
increases expression
ISO
n-hexane results in increased expression of G6PD mRNA
CTD
PMID:20566472
NCBI chr X:156,274,800...156,293,935
Ensembl chr X:156,274,800...156,293,926
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Galnt17
polypeptide N-acetylgalactosaminyltransferase 17
decreases methylation
EXP
n-hexane results in decreased methylation of GALNT17 promoter
CTD
PMID:23740543
NCBI chr12:28,381,879...29,268,457
Ensembl chr12:28,381,982...29,268,073
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Gclc
glutamate-cysteine ligase, catalytic subunit
increases expression
ISO
n-hexane results in increased expression of GCLC mRNA
CTD
PMID:20566472
NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
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Gclm
glutamate cysteine ligase, modifier subunit
increases expression
ISO
n-hexane results in increased expression of GCLM mRNA
CTD
PMID:20566472
NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
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Glrx2
glutaredoxin 2
decreases methylation
EXP
n-hexane results in decreased methylation of GLRX2 promoter
CTD
PMID:23740543
NCBI chr13:60,529,057...60,552,115
Ensembl chr13:60,529,932...60,537,916
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Gna14
G protein subunit alpha 14
decreases methylation
EXP
n-hexane results in decreased methylation of GNA14 promoter
CTD
PMID:23740543
NCBI chr 1:235,165,775...235,347,986
Ensembl chr 1:235,166,718...235,347,937
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Gnaq
G protein subunit alpha q
decreases methylation
EXP
n-hexane results in decreased methylation of GNAQ promoter
CTD
PMID:23740543
NCBI chr 1:233,382,778...233,622,584
Ensembl chr 1:233,382,708...233,622,786
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Gosr1
golgi SNAP receptor complex member 1
decreases methylation
EXP
n-hexane results in decreased methylation of GOSR1 promoter
CTD
PMID:23740543
NCBI chr10:63,405,526...63,442,257
Ensembl chr10:63,405,586...63,442,250
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Grm6
glutamate metabotropic receptor 6
decreases methylation
EXP
n-hexane results in decreased methylation of GRM6 promoter
CTD
PMID:23740543
NCBI chr10:36,345,503...36,363,416
Ensembl chr10:36,345,939...36,360,665
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Gsr
glutathione-disulfide reductase
increases expression
ISO
n-hexane results in increased expression of GSR mRNA
CTD
PMID:20566472
NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
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Hmox1
heme oxygenase 1
increases expression multiple interactions
ISO
n-hexane results in increased expression of HMOX1 mRNA [Particulate Matter co-treated with n-hexane] results in increased expression of HMOX1 mRNA
CTD
PMID:20566472 PMID:30503853
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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Hook1
hook microtubule-tethering protein 1
decreases methylation
EXP
n-hexane results in decreased methylation of HOOK1 promoter
CTD
PMID:23740543
NCBI chr 5:114,940,053...115,000,691
Ensembl chr 5:114,940,053...115,000,691
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Hp1bp3
heterochromatin protein 1, binding protein 3
decreases methylation
EXP
n-hexane results in decreased methylation of HP1BP3 promoter
CTD
PMID:23740543
NCBI chr 5:156,581,732...156,609,059
Ensembl chr 5:156,581,732...156,609,059
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Il1a
interleukin 1 alpha
multiple interactions
ISO
[Particulate Matter co-treated with n-hexane] results in increased expression of IL1A mRNA; carazolol promotes the reaction [[Particulate Matter co-treated with n-hexane] results in increased expression of IL1A mRNA]
CTD
PMID:30503853
NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
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Il1b
interleukin 1 beta
multiple interactions
ISO
[Particulate Matter co-treated with n-hexane] results in increased expression of IL1B mRNA
CTD
PMID:30503853
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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Il6
interleukin 6
increases expression
ISO
n-hexane results in increased expression of IL6 protein
CTD
PMID:23353815
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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Ing2
inhibitor of growth family, member 2
decreases methylation
EXP
n-hexane results in decreased methylation of ING2 promoter
CTD
PMID:23740543
NCBI chr16:47,714,756...47,725,836
Ensembl chr16:47,717,951...47,725,836
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Kcnk1
potassium two pore domain channel subfamily K member 1
increases methylation
EXP
n-hexane results in increased methylation of KCNK1 promoter
CTD
PMID:23740543
NCBI chr19:58,823,836...58,862,926
Ensembl chr19:58,823,814...58,862,926
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Khdrbs1
KH RNA binding domain containing, signal transduction associated 1
decreases methylation
EXP
n-hexane results in decreased methylation of KHDRBS1 promoter
CTD
PMID:23740543
NCBI chr 5:147,927,145...147,953,093
Ensembl chr 5:147,927,152...147,953,093
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Kif15
kinesin family member 15
increases methylation
EXP
n-hexane results in increased methylation of KIF15 promoter
CTD
PMID:23740543
NCBI chr 8:132,033,117...132,103,528
Ensembl chr 8:132,032,944...132,103,927
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Klhl21
kelch-like family member 21
decreases methylation
EXP
n-hexane results in decreased methylation of KLHL21 promoter
CTD
PMID:23740543
NCBI chr 5:169,181,418...169,190,073
Ensembl chr 5:169,181,418...169,190,073
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Krt84
keratin 84
decreases methylation
EXP
n-hexane results in decreased methylation of KRT84 promoter
CTD
PMID:23740543
NCBI chr 7:143,180,212...143,187,684
Ensembl chr 7:143,179,835...143,187,648
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Letm2
leucine zipper and EF-hand containing transmembrane protein 2
decreases methylation
EXP
n-hexane results in decreased methylation of LETM2 promoter
CTD
PMID:23740543
NCBI chr16:71,241,335...71,261,841
Ensembl chr16:71,241,335...71,261,840
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Loxl4
lysyl oxidase-like 4
increases methylation
EXP
n-hexane results in increased methylation of LOXL4 promoter
CTD
PMID:23740543
NCBI chr 1:261,833,365...261,853,599
Ensembl chr 1:261,835,992...261,853,495
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Lrfn1
leucine rich repeat and fibronectin type III domain containing 1
increases methylation
EXP
n-hexane results in increased methylation of LRFN1 promoter
CTD
PMID:23740543
NCBI chr 1:85,290,887...85,308,498
Ensembl chr 1:85,291,462...85,300,825
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Lrfn3
leucine rich repeat and fibronectin type III domain containing 3
decreases methylation
EXP
n-hexane results in decreased methylation of LRFN3 promoter
CTD
PMID:23740543
NCBI chr 1:88,819,439...88,827,002
Ensembl chr 1:88,819,445...88,826,302
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Mafg
MAF bZIP transcription factor G
increases expression
ISO
n-hexane results in increased expression of MAFG mRNA
CTD
PMID:20566472
NCBI chr10:109,802,877...109,811,476
Ensembl chr10:109,806,159...109,811,323
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Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
increases methylation
EXP
n-hexane results in increased methylation of MAGI2 promoter
CTD
PMID:23740543
NCBI chr 4:10,995,241...12,472,423
Ensembl chr 4:10,995,234...11,610,518
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Marchf8
membrane associated ring-CH-type finger 8
decreases methylation
EXP
n-hexane results in decreased methylation of MARCHF8 promoter
CTD
PMID:23740543
NCBI chr 4:148,285,467...148,398,148
Ensembl chr 4:148,286,853...148,398,148
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Mau2
MAU2 sister chromatid cohesion factor
decreases methylation
EXP
n-hexane results in decreased methylation of MAU2 promoter
CTD
PMID:23740543
NCBI chr16:21,132,115...21,163,257
Ensembl chr16:21,132,147...21,163,257
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Mdk
midkine
decreases methylation
EXP
n-hexane results in decreased methylation of MDK promoter
CTD
PMID:23740543
NCBI chr 3:80,841,003...80,843,895
Ensembl chr 3:80,841,005...80,842,916
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Me1
malic enzyme 1
increases expression
ISO
n-hexane results in increased expression of ME1 mRNA
CTD
PMID:20566472
NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834
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Mei1
meiotic double-stranded break formation protein 1
decreases methylation
EXP
n-hexane results in decreased methylation of MEI1 promoter
CTD
PMID:23740543
NCBI chr 7:123,308,041...123,361,391
Ensembl chr 7:123,308,041...123,361,391
G
Mfap2
microfibril associated protein 2
decreases methylation
EXP
n-hexane results in decreased methylation of MFAP2 promoter
CTD
PMID:23740543
NCBI chr 5:159,534,202...159,539,750
Ensembl chr 5:159,534,202...159,539,750
G
Mip
major intrinsic protein of lens fiber
increases methylation
EXP
n-hexane results in increased methylation of MIP promoter
CTD
PMID:23740543
NCBI chr 7:2,635,743...2,642,995
Ensembl chr 7:2,635,743...2,642,848
G
Mpped2
metallophosphoesterase domain containing 2
decreases methylation
EXP
n-hexane results in decreased methylation of MPPED2 promoter
CTD
PMID:23740543
NCBI chr 3:97,720,308...97,899,735
Ensembl chr 3:97,721,668...97,896,422
G
Ndufb4
NADH:ubiquinone oxidoreductase subunit B4
decreases methylation
EXP
n-hexane results in decreased methylation of NDUFB4 promoter
CTD
PMID:23740543
NCBI chr11:65,960,277...65,966,899
Ensembl chr11:65,960,277...65,966,898
G
Ndufb8
NADH:ubiquinone oxidoreductase subunit B8
decreases methylation
EXP
n-hexane results in decreased methylation of NDUFB8 promoter
CTD
PMID:23740543
NCBI chr 1:264,298,671...264,303,712
Ensembl chr 1:264,298,669...264,303,762
G
Nfatc2ip
nuclear factor of activated T-cells 2 interacting protein
increases methylation
EXP
n-hexane results in increased methylation of NFATC2IP promoter
CTD
PMID:23740543
NCBI chr 1:197,785,966...197,800,943
Ensembl chr 1:197,785,968...197,801,634
G
Npepl1
aminopeptidase-like 1
increases methylation
EXP
n-hexane results in increased methylation of NPEPL1 promoter
CTD
PMID:23740543
NCBI chr 3:172,195,115...172,207,685
Ensembl chr 3:172,195,844...172,207,685
G
Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression
ISO
n-hexane results in increased expression of NQO1 mRNA
CTD
PMID:20566472
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
G
Odc1
ornithine decarboxylase 1
decreases methylation
EXP
n-hexane results in decreased methylation of ODC1 promoter
CTD
PMID:23740543
NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
G
Pcid2
PCI domain containing 2
decreases methylation
EXP
n-hexane results in decreased methylation of PCID2 promoter
CTD
PMID:23740543
NCBI chr16:81,757,582...81,783,047
Ensembl chr16:81,756,971...81,783,047
G
Pgd
phosphogluconate dehydrogenase
increases expression
ISO
n-hexane results in increased expression of PGD mRNA
CTD
PMID:20566472
NCBI chr 5:165,966,128...165,982,327
G
Phlda1
pleckstrin homology-like domain, family A, member 1
decreases methylation
EXP
n-hexane results in decreased methylation of PHLDA1 promoter
CTD
PMID:23740543
NCBI chr 7:54,247,460...54,249,664
Ensembl chr 7:54,247,460...54,249,664
G
Poglut3
protein O-glucosyltransferase 3
decreases methylation
EXP
n-hexane results in decreased methylation of POGLUT3 promoter
CTD
PMID:23740543
NCBI chr 8:57,964,988...57,982,605
Ensembl chr 8:57,964,988...57,982,600
G
Ppp1cb
protein phosphatase 1 catalytic subunit beta
decreases methylation
EXP
n-hexane results in decreased methylation of PPP1CB promoter
CTD
PMID:23740543
NCBI chr 6:23,548,507...23,581,136
Ensembl chr 6:23,549,317...23,581,052
G
Prok2
prokineticin 2
decreases methylation
EXP
n-hexane results in decreased methylation of PROK2 promoter
CTD
PMID:23740543
NCBI chr 4:132,157,556...132,171,244
Ensembl chr 4:132,157,556...132,171,153
G
Prpf19
pre-mRNA processing factor 19
decreases methylation
EXP
n-hexane results in decreased methylation of PRPF19 promoter
CTD
PMID:23740543
NCBI chr 1:226,947,065...226,958,147
Ensembl chr 1:226,947,105...226,958,144
G
Prps2
phosphoribosyl pyrophosphate synthetase 2
decreases methylation
EXP
n-hexane results in decreased methylation of PRPS2 promoter
CTD
PMID:23740543
NCBI chr X:28,435,275...28,472,882
Ensembl chr X:28,435,507...28,472,880
G
Ptgr1
prostaglandin reductase 1
increases expression
ISO
n-hexane results in increased expression of PTGR1 mRNA
CTD
PMID:20566472
NCBI chr 5:76,110,746...76,129,361
Ensembl chr 5:76,110,738...76,129,441
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
[Particulate Matter co-treated with n-hexane] results in increased expression of PTGS2 mRNA
CTD
PMID:30503853
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
G
Rab5b
RAB5B, member RAS oncogene family
decreases methylation
EXP
n-hexane results in decreased methylation of RAB5B promoter
CTD
PMID:23740543
NCBI chr 7:3,104,530...3,123,384
Ensembl chr 7:3,104,551...3,123,297
G
Rabl6
RAB, member RAS oncogene family-like 6
decreases methylation
EXP
n-hexane results in decreased methylation of RABL6 promoter
CTD
PMID:23740543
NCBI chr 3:2,806,777...2,832,697
Ensembl chr 3:2,806,777...2,832,697
G
Raly
RALY heterogeneous nuclear ribonucleoprotein
decreases methylation
EXP
n-hexane results in decreased methylation of RALY promoter
CTD
PMID:23740543
NCBI chr 3:150,322,834...150,387,345
Ensembl chr 3:150,323,116...150,387,332
G
Reep1
receptor accessory protein 1
decreases methylation
EXP
n-hexane results in decreased methylation of REEP1 promoter
CTD
PMID:23740543
NCBI chr 4:99,618,622...99,735,329
Ensembl chr 4:99,618,622...99,735,319
G
RGD1311745
similar to RIKEN cDNA 1110059G10
increases methylation
EXP
n-hexane results in increased methylation of RGD1311745 promoter
CTD
PMID:23740543
NCBI chr 8:132,029,618...132,032,971
Ensembl chr 8:132,029,621...132,036,472
G
RGD1311847
similar to 1700030K09Rik protein
increases methylation
EXP
n-hexane results in increased methylation of RGD1311847 promoter
CTD
PMID:23740543
NCBI chr16:19,081,329...19,097,329
Ensembl chr16:19,081,333...19,097,329
G
Rp2
RP2 activator of ARL3 GTPase
decreases methylation
EXP
n-hexane results in decreased methylation of RP2 promoter
CTD
PMID:23740543
NCBI chr X:2,066,298...2,116,661
Ensembl chr X:2,064,486...2,116,656
G
Rprm
reprimo, TP53 dependent G2 arrest mediator homolog
increases methylation
EXP
n-hexane results in increased methylation of RPRM promoter
CTD
PMID:23740543
NCBI chr 3:39,595,301...39,596,718
Ensembl chr 3:39,595,301...39,596,718
G
Rps6ka5
ribosomal protein S6 kinase A5
decreases methylation
EXP
n-hexane results in decreased methylation of RPS6KA5 promoter
CTD
PMID:23740543
NCBI chr 6:124,557,892...124,735,787
Ensembl chr 6:124,557,913...124,735,778
G
Selenov
selenoprotein V
decreases methylation
EXP
n-hexane results in decreased methylation of SELENOV promoter
CTD
PMID:23740543
NCBI chr 1:85,496,940...85,504,189
Ensembl chr 1:85,496,937...85,504,190
G
Sema5b
semaphorin 5B
decreases methylation
EXP
n-hexane results in decreased methylation of SEMA5B promoter
CTD
PMID:23740543
NCBI chr11:68,304,844...68,435,109
Ensembl chr11:68,306,659...68,349,238
G
Serpinb2
serpin family B member 2
multiple interactions
ISO
[Particulate Matter co-treated with n-hexane] results in increased expression of SERPINB2 mRNA
CTD
PMID:30503853
NCBI chr13:27,449,907...27,463,015
Ensembl chr13:27,449,934...27,463,010
G
Sidt2
SID1 transmembrane family, member 2
decreases methylation
EXP
n-hexane results in decreased methylation of SIDT2 promoter
CTD
PMID:23740543
NCBI chr 8:50,230,335...50,246,979
Ensembl chr 8:50,230,339...50,246,656
G
Sipa1l3
signal-induced proliferation-associated 1 like 3
decreases methylation
EXP
n-hexane results in decreased methylation of SIPA1L3 promoter
CTD
PMID:23740543
NCBI chr 1:87,260,832...87,467,846
Ensembl chr 1:87,260,835...87,468,288
G
Slc27a3
solute carrier family 27 member 3
decreases methylation
EXP
n-hexane results in decreased methylation of SLC27A3 promoter
CTD
PMID:23740543
NCBI chr 2:189,760,747...189,765,415
Ensembl chr 2:189,760,747...189,765,415
G
Slc39a14
solute carrier family 39 member 14
increases expression
ISO
n-hexane results in increased expression of SLC39A14 mRNA
CTD
PMID:23353815
NCBI chr15:51,982,872...52,029,841
Ensembl chr15:51,982,982...52,029,816
G
Slc40a1
solute carrier family 40 member 1
decreases expression
ISO
n-hexane results in decreased expression of SLC40A1 mRNA
CTD
PMID:23353815
NCBI chr 9:52,819,451...52,830,461
Ensembl chr 9:52,894,365...52,912,293
G
Slc47a1
solute carrier family 47 member 1
decreases methylation
EXP
n-hexane results in decreased methylation of SLC47A1 promoter
CTD
PMID:23740543
NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921
G
Slc52a3
solute carrier family 52 member 3
decreases methylation
EXP
n-hexane results in decreased methylation of SLC52A3 promoter
CTD
PMID:23740543
NCBI chr 3:147,503,266...147,517,935
Ensembl chr 3:147,511,406...147,516,455
G
Slc7a5
solute carrier family 7 member 5
decreases methylation
EXP
n-hexane results in decreased methylation of SLC7A5 promoter
CTD
PMID:23740543
NCBI chr19:54,693,959...54,722,563
Ensembl chr19:54,693,959...54,722,563
G
Slco4c1
solute carrier organic anion transporter family, member 4C1
decreases methylation
EXP
n-hexane results in decreased methylation of SLCO4C1 promoter
CTD
PMID:23740543
NCBI chr 9:104,301,935...104,350,262
Ensembl chr 9:104,299,277...104,350,308
G
Srxn1
sulfiredoxin 1
increases expression
ISO
n-hexane results in increased expression of SRXN1 mRNA
CTD
PMID:20566472
NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
G
Star
steroidogenic acute regulatory protein
affects expression affects methylation
EXP
n-hexane affects the expression of STAR mRNA; n-hexane affects the expression of STAR protein n-hexane affects the methylation of STAR promoter
CTD
PMID:26410608
NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
G
Sugp1
SURP and G patch domain containing 1
decreases methylation
EXP
n-hexane results in decreased methylation of SUGP1 promoter
CTD
PMID:23740543
NCBI chr16:21,100,923...21,131,795
Ensembl chr16:21,100,924...21,131,795
G
Syngr1
synaptogyrin 1
decreases methylation
EXP
n-hexane results in decreased methylation of SYNGR1 promoter
CTD
PMID:23740543
NCBI chr 7:121,311,008...121,334,437
Ensembl chr 7:121,311,024...121,334,437
G
Tacstd2
tumor-associated calcium signal transducer 2
increases methylation
EXP
n-hexane results in increased methylation of TACSTD2 promoter
CTD
PMID:23740543
NCBI chr 4:98,341,187...98,342,887
Ensembl chr 4:98,341,188...98,342,887
G
Tbcb
tubulin folding cofactor B
increases methylation
EXP
n-hexane results in increased methylation of TBCB promoter
CTD
PMID:23740543
NCBI chr 1:88,680,936...88,686,785
Ensembl chr 1:88,680,856...88,686,615
G
Tex45
testis expressed 45
decreases methylation
EXP
n-hexane results in decreased methylation of TEX45 promoter
CTD
PMID:23740543
NCBI chr12:2,016,035...2,033,140
Ensembl chr12:2,016,058...2,033,112
G
Tmem14c
transmembrane protein 14C
decreases methylation
EXP
n-hexane results in decreased methylation of TMEM14C promoter
CTD
PMID:23740543
NCBI chr17:21,571,510...21,577,651
Ensembl chr17:21,571,518...21,577,631
G
Tspyl4
TSPY-like 4
decreases methylation
EXP
n-hexane results in decreased methylation of TSPYL4 promoter
CTD
PMID:23740543
NCBI chr20:41,100,071...41,102,067
Ensembl chr20:41,100,071...41,102,056
G
Txnrd1
thioredoxin reductase 1
increases expression
ISO
n-hexane results in increased expression of TXNRD1 mRNA
CTD
PMID:20566472
NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
G
Usp11
ubiquitin specific peptidase 11
increases methylation
EXP
n-hexane results in increased methylation of USP11 promoter
CTD
PMID:23740543
NCBI chr X:1,687,820...1,703,991
Ensembl chr X:1,687,811...1,704,033
G
Vegfc
vascular endothelial growth factor C
decreases methylation
EXP
n-hexane results in decreased methylation of VEGFC promoter
CTD
PMID:23740543
NCBI chr16:40,440,371...40,555,178
Ensembl chr16:40,440,207...40,555,576
G
Vim
vimentin
multiple interactions
ISO
n-hexane metabolite promotes the reaction [VIM protein binds to VIM protein]
CTD
PMID:6361548
NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
G
Vstm4
V-set and transmembrane domain containing 4
decreases methylation
EXP
n-hexane results in decreased methylation of VSTM4 promoter
CTD
PMID:23740543
NCBI chr16:9,088,142...9,172,855
Ensembl chr16:9,092,302...9,172,888
G
Wwp1
WW domain containing E3 ubiquitin protein ligase 1
decreases methylation
EXP
n-hexane results in decreased methylation of WWP1 promoter
CTD
PMID:23740543
NCBI chr 5:33,608,489...33,696,487
Ensembl chr 5:33,609,136...33,664,435
G
Zfp593
zinc finger protein 593
increases methylation
EXP
n-hexane results in increased methylation of ZFP593 promoter
CTD
PMID:23740543
NCBI chr 5:152,462,522...152,464,850
Ensembl chr 5:152,462,522...152,464,850
G
Zpr1
ZPR1 zinc finger
decreases methylation
EXP
n-hexane results in decreased methylation of ZPR1 promoter
CTD
PMID:23740543
NCBI chr 8:50,563,047...50,572,621
Ensembl chr 8:50,563,047...50,572,621
G
Abi2
abl-interactor 2
increases expression
EXP
2,5-hexanedione results in increased expression of ABI2 mRNA
CTD
PMID:22952946 PMID:27466211
NCBI chr 9:67,234,612...67,284,504
Ensembl chr 9:67,234,303...67,282,600
G
Aco2
aconitase 2
increases expression
EXP
2,5-hexanedione results in increased expression of ACO2 protein
CTD
PMID:19033394
NCBI chr 7:123,102,493...123,145,608
Ensembl chr 7:123,102,468...123,145,635
G
Aif1
allograft inflammatory factor 1
increases expression multiple interactions
EXP
2,5-hexanedione results in increased expression of AIF1 protein Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of AIF1 protein]
CTD
PMID:32522579
NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
G
Alox15b
arachidonate 15-lipoxygenase, type B
decreases expression
EXP
2,5-hexanedione results in decreased expression of ALOX15B mRNA
CTD
PMID:22952946
NCBI chr10:55,773,748...55,783,489
Ensembl chr10:55,774,006...55,783,489
G
Angptl4
angiopoietin-like 4
affects expression
EXP
2,5-hexanedione affects the expression of ANGPTL4 mRNA
CTD
PMID:20616210
NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079
G
Arg1
arginase 1
decreases expression multiple interactions
EXP
2,5-hexanedione results in decreased expression of ARG1 mRNA Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of ARG1 mRNA]
CTD
PMID:32522579
NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
G
Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO EXP
2,5-hexanedione results in increased expression of BAX mRNA; 2,5-hexanedione results in increased expression of BAX protein
CTD
PMID:17492505 PMID:21901545 PMID:22337490
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
G
Bcl2
BCL2, apoptosis regulator
increases expression decreases expression
EXP ISO
2,5-hexanedione results in increased expression of BCL2 protein 2,5-hexanedione results in decreased expression of BCL2 mRNA 2,5-hexanedione results in decreased expression of BCL2 mRNA; 2,5-hexanedione results in decreased expression of BCL2 protein
CTD
PMID:17492505 PMID:21901545 PMID:22337490
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
G
Bcl2l14
BCL2 like 14
increases expression
EXP
2,5-hexanedione results in increased expression of BCL2L14 mRNA
CTD
PMID:22952946
NCBI chr 4:168,139,964...168,183,726
Ensembl chr 4:168,142,271...168,183,096
G
Bdnf
brain-derived neurotrophic factor
decreases expression
EXP
2,5-hexanedione results in decreased expression of BDNF protein
CTD
PMID:31760062
NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
G
Bfar
bifunctional apoptosis regulator
increases expression
EXP
2,5-hexanedione results in increased expression of BFAR mRNA
CTD
PMID:22952946
NCBI chr10:1,464,658...1,471,152 NCBI chr10:1,464,783...1,497,653
Ensembl chr10:1,464,765...1,497,653
G
Casp1
caspase 1
increases cleavage multiple interactions
EXP
2,5-hexanedione results in increased cleavage of CASP1 protein Glyburide inhibits the reaction [2,5-hexanedione results in increased cleavage of CASP1 protein]
CTD
PMID:32522579
NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
G
Casp3
caspase 3
increases expression
ISO EXP
2,5-hexanedione results in increased expression of CASP3 mRNA; 2,5-hexanedione results in increased expression of CASP3 protein alternative form
CTD
PMID:17492505 PMID:21901545
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
G
Ccdc171
coiled-coil domain containing 171
increases expression
EXP
2,5-hexanedione results in increased expression of CCDC171 mRNA
CTD
PMID:22952946
NCBI chr 5:101,639,355...102,017,300
G
Ccdc191
coiled-coil domain containing 191
increases expression
EXP
2,5-hexanedione results in increased expression of CCDC191 mRNA
CTD
PMID:22952946
NCBI chr11:61,678,138...61,748,773
Ensembl chr11:61,678,045...61,748,768
G
Cdin1
CDAN1 interacting nuclease 1
increases expression
EXP
2,5-hexanedione results in increased expression of CDIN1 mRNA
CTD
PMID:22952946
NCBI chr 3:107,142,734...107,347,381
Ensembl chr 3:107,142,762...107,348,650
G
Cep112
centrosomal protein 112
increases expression
EXP
2,5-hexanedione results in increased expression of CEP112 mRNA
CTD
PMID:22952946
NCBI chr10:96,660,294...97,146,426
Ensembl chr10:96,663,740...97,146,424
G
Cfap221
cilia and flagella associated protein 221
increases expression
EXP
2,5-hexanedione results in increased expression of CFAP221 mRNA
CTD
PMID:22952946
NCBI chr13:35,952,808...36,024,371
Ensembl chr13:35,953,088...36,022,197
G
Ckmt1
creatine kinase, mitochondrial 1
increases expression
EXP
2,5-hexanedione results in increased expression of CKMT1B protein
CTD
PMID:19033394
NCBI chr 3:113,318,559...113,324,459
Ensembl chr 3:113,318,563...113,324,461
G
Clca2
chloride channel accessory 2
multiple interactions
EXP
[carbendazim co-treated with 2,5-hexanedione] results in decreased expression of CLCA2 mRNA
CTD
PMID:22382377
NCBI chr 2:250,954,423...250,981,544
Ensembl chr 2:250,954,397...250,981,623
G
Clu
clusterin
decreases expression increases expression
EXP
2,5-hexanedione results in decreased expression of CLU mRNA 2,5-hexanedione results in increased expression of CLU mRNA
CTD
PMID:22952946 PMID:27466211
NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
G
Ctxn1
cortexin 1
increases expression
EXP
2,5-hexanedione results in increased expression of CTXN1 mRNA
CTD
PMID:22952946
NCBI chr12:2,534,212...2,535,823
Ensembl chr12:2,534,212...2,535,822
G
Dcn
decorin
increases expression
EXP
2,5-hexanedione results in increased expression of DCN mRNA
CTD
PMID:22952946
NCBI chr 7:38,742,250...38,782,282
Ensembl chr 7:38,742,051...38,782,323
G
Dennd1a
DENN domain containing 1A
increases expression
EXP
2,5-hexanedione results in increased expression of DENND1A mRNA
CTD
PMID:22952946
NCBI chr 3:22,061,120...22,501,502
Ensembl chr 3:22,058,400...22,500,765
G
Dnajb4
DnaJ heat shock protein family (Hsp40) member B4
increases expression
EXP
2,5-hexanedione results in increased expression of DNAJB4 mRNA
CTD
PMID:22952946
NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242
G
Dpp7
dipeptidylpeptidase 7
multiple interactions
EXP
[carbendazim co-treated with 2,5-hexanedione] results in decreased expression of DPP7 mRNA
CTD
PMID:22382377
NCBI chr 3:2,569,135...2,573,387
Ensembl chr 3:2,569,135...2,573,387
G
Dpysl2
dihydropyrimidinase-like 2
decreases expression
EXP
2,5-hexanedione results in decreased expression of DPYSL2 protein
CTD
PMID:19033394
NCBI chr15:43,475,640...43,581,725
Ensembl chr15:43,477,629...43,542,939
G
Egfr
epidermal growth factor receptor
increases expression
EXP
2,5-hexanedione results in increased expression of EGFR mRNA
CTD
PMID:16141653
NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
G
Erc1
ELKS/RAB6-interacting/CAST family member 1
increases expression
EXP
2,5-hexanedione results in increased expression of ERC1 mRNA
CTD
PMID:22952946
NCBI chr 4:152,087,393...152,380,023
Ensembl chr 4:152,087,379...152,380,184
G
Faslg
Fas ligand
increases expression
EXP
2,5-hexanedione results in increased expression of FASLG mRNA
CTD
PMID:22337490
NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
G
Fasn
fatty acid synthase
decreases expression
EXP
2,5-hexanedione results in decreased expression of FASN protein
CTD
PMID:19033394
NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
G
Fcer1g
Fc fragment of IgE receptor Ig
increases expression
EXP
2,5-hexanedione results in increased expression of FCER1G mRNA
CTD
PMID:22952946
NCBI chr13:89,601,894...89,606,326
Ensembl chr13:89,601,896...89,606,326
G
Gadd45a
growth arrest and DNA-damage-inducible, alpha
increases expression
EXP
2,5-hexanedione results in increased expression of GADD45 mRNA
CTD
PMID:16141653
NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
G
Gas2
growth arrest-specific 2
increases expression
EXP
2,5-hexanedione results in increased expression of GAS2 mRNA
CTD
PMID:22952946
NCBI chr 1:107,234,389...107,363,624
Ensembl chr 1:107,262,659...107,363,788
G
Gfap
glial fibrillary acidic protein
decreases expression increases expression
EXP
2,5-hexanedione results in decreased expression of GFAP protein 2,5-hexanedione results in increased expression of GFAP protein
CTD
PMID:19033394
NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
G
Ghsr
growth hormone secretagogue receptor
affects expression
EXP
2,5-hexanedione affects the expression of GHSR mRNA
CTD
PMID:20616210
NCBI chr 2:113,065,953...113,071,265
Ensembl chr 2:113,066,885...113,070,261
G
Glud1
glutamate dehydrogenase 1
increases expression
EXP
2,5-hexanedione results in increased expression of GLUD1 protein
CTD
PMID:19033394
NCBI chr16:10,661,486...10,695,557
Ensembl chr16:10,662,021...10,695,557
G
Gsdmd
gasdermin D
multiple interactions increases cleavage
EXP
Glyburide inhibits the reaction [2,5-hexanedione results in increased cleavage of GSDMD protein]
CTD
PMID:32522579
NCBI chr 7:116,889,147...116,894,134
Ensembl chr 7:116,889,572...116,894,134
G
Gsk3b
glycogen synthase kinase 3 beta
decreases expression
EXP
2,5-hexanedione results in decreased expression of GSK3B protein
CTD
PMID:31760062
NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
G
Gsn
gelsolin
decreases expression
EXP
2,5-hexanedione results in decreased expression of GSN protein
CTD
PMID:19033394
NCBI chr 3:14,456,106...14,508,922
Ensembl chr 3:14,467,330...14,508,911
G
Gstm3l
glutathione S-transferase mu 3-like
decreases expression
EXP
2,5-hexanedione results in decreased expression of GSTM5 protein
CTD
PMID:19033394
NCBI chr 2:210,761,729...210,766,501
Ensembl chr 2:210,761,729...210,766,501
G
Gstp1
glutathione S-transferase pi 1
decreases expression
EXP
2,5-hexanedione results in decreased expression of GSTP1 mRNA
CTD
PMID:16141653
NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
G
Hdgfl1
HDGF like 1
decreases expression
EXP
2,5-hexanedione results in decreased expression of HDGFL1 mRNA
CTD
PMID:22952946
NCBI chr17:40,170,522...40,172,518
Ensembl chr17:40,170,541...40,172,426
G
Hspa1b
heat shock protein family A (Hsp70) member 1B
increases expression
EXP
2,5-hexanedione results in increased expression of HSPA1B mRNA
CTD
PMID:16141653
NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
G
Ier3
immediate early response 3
affects expression
EXP
2,5-hexanedione affects the expression of IER3 mRNA
CTD
PMID:20616210
NCBI chr20:3,438,798...3,440,002
Ensembl chr20:3,438,798...3,440,769
G
Ift81
intraflagellar transport 81
increases expression
EXP
2,5-hexanedione results in increased expression of IFT81 mRNA
CTD
PMID:22952946
NCBI chr12:39,420,161...39,507,412
Ensembl chr12:39,423,596...39,506,890
G
Igfbp3
insulin-like growth factor binding protein 3
decreases expression
EXP
2,5-hexanedione results in decreased expression of IGFBP3 mRNA
CTD
PMID:16141653
NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
G
Il1b
interleukin 1 beta
increases expression multiple interactions
EXP
2,5-hexanedione results in increased expression of IL1B mRNA; 2,5-hexanedione results in increased expression of IL1B protein Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of IL1B protein]
CTD
PMID:16141653 PMID:32522579
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
G
Ina
internexin neuronal intermediate filament protein, alpha
decreases expression
EXP
2,5-hexanedione results in decreased expression of INA protein
CTD
PMID:19033394
NCBI chr 1:266,782,835...266,794,389
Ensembl chr 1:266,781,617...266,794,431
G
Itgam
integrin subunit alpha M
increases expression multiple interactions
ISO EXP
2,5-hexanedione results in increased expression of ITGAM protein Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of ITGAM protein]
CTD
PMID:19464574 PMID:32522579
NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
G
Itgb1
integrin subunit beta 1
decreases expression
EXP
2,5-hexanedione results in decreased expression of ITGB1 mRNA
CTD
PMID:16141653
NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
G
Kif6
kinesin family member 6
increases expression
EXP
2,5-hexanedione results in increased expression of KIF6 mRNA
CTD
PMID:22952946
NCBI chr 9:13,016,973...13,311,971
Ensembl chr 9:13,030,673...13,311,924
G
Kit
KIT proto-oncogene receptor tyrosine kinase
decreases expression multiple interactions
EXP
2,5-hexanedione results in decreased expression of KIT protein resveratrol inhibits the reaction [2,5-hexanedione results in decreased expression of KIT protein]
CTD
PMID:17725299
NCBI chr14:35,072,131...35,149,638
Ensembl chr14:35,072,108...35,149,610
G
Loxl1
lysyl oxidase-like 1
increases expression multiple interactions
EXP
2,5-hexanedione results in increased expression of LOXL1 protein 2,5-hexanedione promotes the reaction [carbendazim results in increased expression of LOXL1 protein]; [carbendazim co-treated with 2,5-hexanedione] results in decreased expression of LOXL1 mRNA
CTD
PMID:22382377
NCBI chr 8:63,067,757...63,092,124
Ensembl chr 8:63,067,300...63,092,009
G
Lrrc6
leucine rich repeat containing 6
increases expression
EXP
2,5-hexanedione results in increased expression of LRRC6 mRNA
CTD
PMID:22952946
NCBI chr 7:107,130,402...107,231,507
Ensembl chr 7:107,130,402...107,223,047
G
Lrrc69
leucine rich repeat containing 69
increases expression
EXP
2,5-hexanedione results in increased expression of LRRC69 mRNA
CTD
PMID:22952946
NCBI chr 5:28,133,066...28,321,877
Ensembl chr 5:28,133,068...28,317,943
G
Lyz2
lysozyme 2
decreases expression increases expression
EXP
2,5-hexanedione results in decreased expression of LYZ2 mRNA 2,5-hexanedione results in increased expression of LYZ2 mRNA
CTD
PMID:22952946
NCBI chr 7:60,335,968...60,341,264
Ensembl chr 7:60,335,969...60,341,264
G
Macrod1
mono-ADP ribosylhydrolase 1
increases expression multiple interactions
EXP
2,5-hexanedione results in increased expression of MACROD1 mRNA [carbendazim co-treated with 2,5-hexanedione] results in decreased expression of MACROD1 mRNA
CTD
PMID:22382377
NCBI chr 1:222,310,916...222,451,485
Ensembl chr 1:222,310,920...222,451,484
G
Map1a
microtubule-associated protein 1A
decreases expression
EXP
2,5-hexanedione results in decreased expression of MAP1A protein
CTD
PMID:20554699
NCBI chr 3:113,251,918...113,272,193
Ensembl chr 3:113,251,778...113,272,186
G
Map1b
microtubule-associated protein 1B
decreases expression
EXP
2,5-hexanedione results in decreased expression of MAP1B protein; 2,5-hexanedione results in decreased expression of MAP1B protein modified form
CTD
PMID:20554699 PMID:31760062
NCBI chr 2:29,675,391...29,768,750
Ensembl chr 2:29,675,391...29,768,750
G
Map2
microtubule-associated protein 2
decreases expression
EXP
2,5-hexanedione results in decreased expression of MAP2 protein modified form
CTD
PMID:20554699
NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972
G
Map3k1
mitogen-activated protein kinase kinase kinase 1
increases expression
EXP
2,5-hexanedione results in increased expression of MAP3K1 protein
CTD
PMID:31760062
NCBI chr 2:43,329,516...43,393,203
Ensembl chr 2:43,329,516...43,393,207
G
Mapt
microtubule-associated protein tau
decreases expression
EXP
2,5-hexanedione results in decreased expression of MAPT protein modified form
CTD
PMID:20554699
NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
G
Mbp
myelin basic protein
multiple interactions decreases expression
EXP
Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of MBP protein]
CTD
PMID:32522579
NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
G
Mdh1
malate dehydrogenase 1
increases expression
EXP
2,5-hexanedione results in increased expression of MDH1 protein
CTD
PMID:19033394
NCBI chr14:106,378,349...106,393,642
Ensembl chr14:106,378,942...106,393,670
G
Mfap3l
microfibril associated protein 3 like
increases expression
EXP
2,5-hexanedione results in increased expression of MFAP3L mRNA
CTD
PMID:22952946
NCBI chr16:32,734,059...32,777,091
Ensembl chr16:32,738,265...32,753,278
G
Mir10b
microRNA 10b
increases expression
EXP
2,5-hexanedione results in increased expression of MIR10B mRNA
CTD
PMID:31760062
NCBI chr 3:61,647,978...61,648,086
Ensembl chr 3:61,647,978...61,648,086
G
Mir1224
microRNA 1224
increases expression
EXP
2,5-hexanedione results in increased expression of MIR1224 mRNA
CTD
PMID:31760062
NCBI chr11:83,992,628...83,992,712
Ensembl chr11:83,992,628...83,992,712
G
Mir125a
microRNA 125a
increases expression decreases expression
EXP
2,5-hexanedione results in increased expression of MIR125A mRNA 2,5-hexanedione results in decreased expression of MIR125A mRNA
CTD
PMID:31760062
NCBI chr 1:59,704,827...59,704,911
Ensembl chr 1:59,704,827...59,704,911
G
Mir130b
microRNA 130b
decreases expression
EXP
2,5-hexanedione results in decreased expression of MIR130B mRNA
CTD
PMID:31760062
NCBI chr11:88,129,773...88,129,854
Ensembl chr11:88,129,773...88,129,854
G
Mir134
microRNA 134
decreases expression
EXP
2,5-hexanedione results in decreased expression of MIR134 mRNA
CTD
PMID:31760062
NCBI chr 6:133,884,547...133,884,619
Ensembl chr 6:133,884,531...133,884,633
G
Mir155
microRNA 155
decreases expression
EXP
2,5-hexanedione results in decreased expression of MIR155 mRNA
CTD
PMID:31760062
NCBI chr11:24,176,603...24,176,667
Ensembl chr11:24,176,603...24,176,667
G
Mir183
microRNA 183
decreases expression
EXP
2,5-hexanedione results in decreased expression of MIR183 mRNA
CTD
PMID:31760062
NCBI chr 4:57,463,569...57,463,678
Ensembl chr 4:57,463,569...57,463,678
G
Mir193
microRNA 193
increases expression
EXP
2,5-hexanedione results in increased expression of MIR193 mRNA
CTD
PMID:31760062
NCBI chr10:67,065,896...67,065,981
G
Mir193a
microRNA 193a
decreases expression
EXP
2,5-hexanedione results in decreased expression of MIR193A mRNA
CTD
PMID:31760062
NCBI chr10:67,065,885...67,065,996
Ensembl chr10:67,065,885...67,065,996
G
Mir194-2
microRNA 194-2
decreases expression
EXP
2,5-hexanedione results in decreased expression of MIR194-2 mRNA
CTD
PMID:31760062
NCBI chr 1:221,634,786...221,634,870
Ensembl chr 1:221,634,786...221,634,870
G
Mir196a
microRNA 196a
increases expression
EXP
2,5-hexanedione results in increased expression of MIR196A mRNA
CTD
PMID:31760062
NCBI chr 7:144,584,235...144,584,344
Ensembl chr 7:144,584,235...144,584,344
G
Mir196c
microRNA 196c
increases expression
EXP
2,5-hexanedione results in increased expression of MIR196C mRNA
CTD
PMID:31760062
NCBI chr10:84,113,578...84,113,657
Ensembl chr10:84,113,578...84,113,657
G
Mir199a2
microRNA 199a-2
decreases expression
EXP
2,5-hexanedione results in decreased expression of MIR199A-2 mRNA; 2,5-hexanedione results in decreased expression of MIR199A2 mRNA
CTD
PMID:31760062
NCBI chr13:80,125,487...80,125,596
Ensembl chr13:80,125,487...80,125,596
G
Mir200c
microRNA 200c
decreases expression
EXP
2,5-hexanedione results in decreased expression of MIR200C mRNA
CTD
PMID:31760062
NCBI chr 4:157,236,786...157,236,854
G
Mir202
microRNA 202
decreases expression
EXP
2,5-hexanedione results in decreased expression of MIR202 mRNA
CTD
PMID:31760062
NCBI chr 1:212,295,630...212,295,701
Ensembl chr 1:212,295,630...212,295,701
G
Mir206
microRNA 206
decreases expression
EXP
2,5-hexanedione results in decreased expression of MIR206 mRNA
CTD
PMID:31760062
NCBI chr 9:26,791,764...26,791,847
Ensembl chr 9:26,791,764...26,791,847
G
Mir208a
microRNA 208a
increases expression
EXP
2,5-hexanedione results in increased expression of MIR208A mRNA
CTD
PMID:31760062
NCBI chr15:33,613,451...33,613,533
G
Mir20a
microRNA 20a
decreases expression
EXP
2,5-hexanedione results in decreased expression of MIR20A mRNA
CTD
PMID:31760062
NCBI chr15:100,180,334...100,180,418
Ensembl chr15:100,180,334...100,180,418
G
Mir21
microRNA 21
increases expression decreases expression
EXP
2,5-hexanedione results in increased expression of MIR21 mRNA 2,5-hexanedione results in decreased expression of MIR21 mRNA
CTD
PMID:31760062
NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
G
Mir212
microRNA 212
increases expression
EXP
2,5-hexanedione results in increased expression of MIR212 mRNA
CTD
PMID:31760062
NCBI chr10:62,014,702...62,014,812
Ensembl chr10:62,014,702...62,014,812
G
Mir22
microRNA 22
increases expression
EXP
2,5-hexanedione results in increased expression of MIR22 mRNA
CTD
PMID:31760062
NCBI chr10:62,299,592...62,299,686
Ensembl chr10:62,299,592...62,299,686
G
Mir223
microRNA 223
increases expression
EXP
2,5-hexanedione results in increased expression of MIR223 mRNA
CTD
PMID:31760062
NCBI chr X:65,367,812...65,367,921
Ensembl chr X:65,367,812...65,367,921
G
Mir224
microRNA 224
increases expression
EXP
2,5-hexanedione results in increased expression of MIR224 mRNA
CTD
PMID:31760062
NCBI chr X:152,223,754...152,223,835
Ensembl chr X:152,223,754...152,223,835
G
Mir27a
microRNA 27a
decreases expression
EXP
2,5-hexanedione results in decreased expression of MIR27A mRNA
CTD
PMID:31760062
NCBI chr19:25,318,736...25,318,822
Ensembl chr19:25,318,736...25,318,822
G
Mir27b
microRNA 27b
increases expression
EXP
2,5-hexanedione results in increased expression of MIR27B mRNA
CTD
PMID:31760062
NCBI chr17:823,461...823,557
Ensembl chr17:823,461...823,557
G
Mir300
microRNA 300
increases expression
EXP
2,5-hexanedione results in increased expression of MIR300 mRNA
CTD
PMID:31760062
NCBI chr 6:133,874,152...133,874,230
Ensembl chr 6:133,874,144...133,874,233
G
Mir30a
microRNA 30a
increases expression
EXP
2,5-hexanedione results in increased expression of MIR30A mRNA
CTD
PMID:31760062
NCBI chr 9:29,542,635...29,542,705
Ensembl chr 9:29,542,635...29,542,705
G
Mir32
microRNA 32
increases expression
EXP
2,5-hexanedione results in increased expression of MIR32 mRNA
CTD
PMID:31760062
NCBI chr 5:73,934,255...73,934,324
Ensembl chr 5:73,934,255...73,934,324
G
Mir320a
microRNA 320a
increases expression
EXP
2,5-hexanedione results in increased expression of MIR320A mRNA
CTD
PMID:31760062
NCBI chr15:52,134,276...52,134,357
Ensembl chr15:52,134,276...52,134,357
G
Mir323
microRNA 323
decreases expression
EXP
2,5-hexanedione results in decreased expression of MIR323 mRNA
CTD
PMID:31760062
NCBI chr 6:133,861,199...133,861,284
Ensembl chr 6:133,861,199...133,861,284
G
Mir326
microRNA 326
increases expression
EXP
2,5-hexanedione results in increased expression of MIR326 mRNA
CTD
PMID:31760062
NCBI chr 1:164,518,401...164,518,495
Ensembl chr 1:164,518,401...164,518,495
G
Mir33
microRNA 33
increases expression
EXP
2,5-hexanedione results in increased expression of MIR33 mRNA
CTD
PMID:31760062
NCBI chr 7:123,431,612...123,431,680
Ensembl chr 7:123,431,612...123,431,680
G
Mir330
microRNA 330
increases expression
EXP
2,5-hexanedione results in increased expression of MIR330 mRNA
CTD
PMID:31760062
NCBI chr 1:80,092,681...80,092,777
Ensembl chr 1:80,092,681...80,092,777
G
Mir331
microRNA 331
decreases expression
EXP
2,5-hexanedione results in decreased expression of MIR331 mRNA
CTD
PMID:31760062
NCBI chr 7:34,881,095...34,881,190
Ensembl chr 7:34,881,095...34,881,190
G
Mir339
microRNA 339
increases expression
EXP
2,5-hexanedione results in increased expression of MIR339 mRNA
CTD
PMID:31760062
NCBI chr12:17,369,002...17,369,097
Ensembl chr12:17,369,002...17,369,097
G
Mir344-1
microRNA 344-1
decreases expression
EXP
2,5-hexanedione results in decreased expression of MIR344-1 mRNA
CTD
PMID:31760062
G
Mir345
microRNA 345
increases expression
EXP
2,5-hexanedione results in increased expression of MIR345 mRNA
CTD
PMID:31760062
NCBI chr 6:132,748,968...132,749,063
Ensembl chr 6:132,748,968...132,749,063
G
Mir3556a
microRNA 3556a
decreases expression
EXP
2,5-hexanedione results in decreased expression of MIR3556A mRNA
CTD
PMID:31760062
NCBI chr 4:58,343,919...58,344,036
Ensembl chr 4:58,343,919...58,344,036
G
Mir3558
microRNA 3558
decreases expression
EXP
2,5-hexanedione results in decreased expression of MIR3558 mRNA
CTD
PMID:31760062
NCBI chr 6:10,992,691...10,992,804
Ensembl chr 6:10,992,691...10,992,804
G
Mir3560
microRNA 3560
decreases expression
EXP
2,5-hexanedione results in decreased expression of MIR3560 mRNA
CTD
PMID:31760062
NCBI chr X:16,117,863...16,117,974
Ensembl chr X:16,117,863...16,117,974
G
Mir3573
microRNA 3573
increases expression
EXP
2,5-hexanedione results in increased expression of MIR3573 mRNA
CTD
PMID:31760062
NCBI chr X:68,892,972...68,893,043
Ensembl chr X:68,892,972...68,893,043
G
Mir3580
microRNA 3580
decreases expression
EXP
2,5-hexanedione results in decreased expression of MIR3580 mRNA
CTD
PMID:31760062
NCBI chr X:151,295,615...151,295,695
Ensembl chr X:151,295,615...151,295,695
G
Mir3593
microRNA 3593
decreases expression
EXP
2,5-hexanedione results in decreased expression of MIR3593 mRNA
CTD
PMID:31760062
NCBI chr 6:76,661,799...76,661,889
Ensembl chr 6:76,661,799...76,661,889
G
Mir370
microRNA 370
decreases expression
EXP
2,5-hexanedione results in decreased expression of MIR370 mRNA
CTD
PMID:31760062
NCBI chr 6:133,739,916...133,739,994
Ensembl chr 6:133,739,916...133,739,994
G
Mir375
microRNA 375
decreases expression
EXP
2,5-hexanedione results in decreased expression of MIR375 mRNA
CTD
PMID:31760062
NCBI chr 9:82,161,716...82,161,790
Ensembl chr 9:82,161,716...82,161,790
G
Mir412
microRNA 412
increases expression
EXP
2,5-hexanedione results in increased expression of MIR412 mRNA
CTD
PMID:31760062
NCBI chr 6:133,893,571...133,893,640
Ensembl chr 6:133,893,565...133,893,644
G
Mir423
microRNA 423
increases expression
EXP
2,5-hexanedione results in increased expression of MIR423 mRNA
CTD
PMID:31760062
NCBI chr10:63,098,366...63,098,444
Ensembl chr10:63,098,360...63,098,453
G
Mir433
microRNA 433
decreases expression
EXP
2,5-hexanedione results in decreased expression of MIR433 mRNA
CTD
PMID:31760062
NCBI chr 6:133,712,334...133,712,426
Ensembl chr 6:133,712,334...133,712,426
G
Mir450a1
microRNA 450a-1
decreases expression
EXP
2,5-hexanedione results in decreased expression of MIR450A1 mRNA
CTD
PMID:31760062
NCBI chr X:158,153,377...158,153,467
Ensembl chr X:158,153,377...158,153,467
G
Mir487b
microRNA 487b
increases expression
EXP
2,5-hexanedione results in increased expression of MIR487B mRNA
CTD
PMID:31760062
NCBI chr 6:133,877,124...133,877,205
Ensembl chr 6:133,877,124...133,877,205
G
Mir488
microRNA 488
increases expression
EXP
2,5-hexanedione results in increased expression of MIR488 mRNA
CTD
PMID:31760062
NCBI chr13:76,198,593...76,198,671
Ensembl chr13:76,198,593...76,198,671
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Mir497
microRNA 497
decreases expression
EXP
2,5-hexanedione results in decreased expression of MIR497 mRNA
CTD
PMID:31760062
NCBI chr10:56,844,977...56,845,045
Ensembl chr10:56,844,977...56,845,045
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Mir503
microRNA 503
decreases expression
EXP
2,5-hexanedione results in decreased expression of MIR503 mRNA
CTD
PMID:31760062
NCBI chr X:158,148,476...158,148,546
Ensembl chr X:158,148,476...158,148,546
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Mir541
microRNA 541
decreases expression
EXP
2,5-hexanedione results in decreased expression of MIR541 mRNA
CTD
PMID:31760062
NCBI chr 6:133,892,655...133,892,744
Ensembl chr 6:133,892,655...133,892,744
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Mir542
microRNA 542
increases expression
EXP
2,5-hexanedione results in increased expression of MIR542 mRNA
CTD
PMID:31760062
NCBI chr X:158,152,146...158,152,224
Ensembl chr X:158,152,146...158,152,224
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Mir551b
microRNA 551b
decreases expression
EXP
2,5-hexanedione results in decreased expression of MIR551B mRNA
CTD
PMID:31760062
NCBI chr 2:116,867,647...116,867,744
Ensembl chr 2:116,867,647...116,867,744
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Mir582
microRNA 582
increases expression
EXP
2,5-hexanedione results in increased expression of MIR582 mRNA
CTD
PMID:31760062
NCBI chr 2:40,863,750...40,863,830
Ensembl chr 2:40,863,750...40,863,830
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Mir652
microRNA 652
decreases expression
EXP
2,5-hexanedione results in decreased expression of MIR652 mRNA
CTD
PMID:31760062
NCBI chr X:114,002,534...114,002,614
Ensembl chr X:114,002,534...114,002,614
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Mir653
microRNA 653
decreases expression
EXP
2,5-hexanedione results in decreased expression of MIR653 mRNA
CTD
PMID:31760062
NCBI chr 4:28,658,882...28,658,978
Ensembl chr 4:28,658,882...28,658,978
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Mir665
microRNA 665
increases expression
EXP
2,5-hexanedione results in increased expression of MIR665 mRNA
CTD
PMID:31760062
NCBI chr 6:133,706,457...133,706,550
Ensembl chr 6:133,706,457...133,706,550
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Mir675
microRNA 675
increases expression
EXP
2,5-hexanedione results in increased expression of MIR675 mRNA
CTD
PMID:31760062
NCBI chr 1:215,745,981...215,746,064
Ensembl chr 1:215,745,981...215,746,064
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Mir743a
microRNA 743a
increases expression
EXP
2,5-hexanedione results in increased expression of MIR743A mRNA
CTD
PMID:31760062
NCBI chr X:151,252,828...151,252,903
Ensembl chr X:151,252,828...151,252,903
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Mir760
microRNA 760
decreases expression
EXP
2,5-hexanedione results in decreased expression of MIR760 mRNA
CTD
PMID:31760062
NCBI chr 2:225,873,354...225,873,433
Ensembl chr 2:225,873,354...225,873,433
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Mir770
microRNA 770
increases expression
EXP
2,5-hexanedione results in increased expression of MIR770 mRNA
CTD
PMID:31760062
NCBI chr 6:133,682,965...133,683,040
Ensembl chr 6:133,682,957...133,683,050
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Mir7a2
microRNA 7a-2
increases expression
EXP
2,5-hexanedione results in increased expression of MIR7A2 mRNA
CTD
PMID:31760062
NCBI chr 1:140,576,396...140,576,490
Ensembl chr 1:140,576,396...140,576,490
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Mir873
microRNA 873
increases expression
EXP
2,5-hexanedione results in increased expression of MIR873 mRNA
CTD
PMID:31760062
NCBI chr 5:52,481,076...52,481,152
Ensembl chr 5:52,481,076...52,481,152
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Mir877
microRNA 877
increases expression
EXP
2,5-hexanedione results in increased expression of MIR877 mRNA
CTD
PMID:31760062
NCBI chr20:3,318,872...3,318,956
Ensembl chr20:3,318,872...3,318,956
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Mir883
microRNA 883
decreases expression
EXP
2,5-hexanedione results in decreased expression of MIR883 mRNA
CTD
PMID:31760062
NCBI chr X:151,260,703...151,260,779
Ensembl chr X:151,260,703...151,260,779
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Mirlet7b
microRNA let-7b
increases expression
EXP
2,5-hexanedione results in increased expression of MIRLET7B mRNA
CTD
PMID:31760062
NCBI chr 7:126,590,627...126,590,711
Ensembl chr 7:126,590,627...126,590,711
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Mirlet7i
microRNA let-7i
increases expression
EXP
2,5-hexanedione results in increased expression of MIRLET7I mRNA
CTD
PMID:31760062
NCBI chr 7:66,802,731...66,802,815
Ensembl chr 7:66,802,732...66,802,821
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Mrc1
mannose receptor, C type 1
decreases expression multiple interactions
EXP
2,5-hexanedione results in decreased expression of MRC1 mRNA Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of MRC1 mRNA]
CTD
PMID:32522579
NCBI chr17:81,352,700...81,433,743
Ensembl chr17:81,352,700...81,433,743
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Mtm1
myotubularin 1
increases expression
EXP
2,5-hexanedione results in increased expression of MTM1 mRNA
CTD
PMID:22952946
NCBI chr 6:18,821,821...18,840,449
Ensembl chr 6:18,821,815...18,839,409
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Napa
NSF attachment protein alpha
decreases expression
EXP
2,5-hexanedione results in decreased expression of NAPA protein
CTD
PMID:19033394
NCBI chr 1:77,994,227...78,012,846
Ensembl chr 1:77,994,203...78,012,845
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Ndufa10
NADH:ubiquinone oxidoreductase subunit A10
increases expression decreases expression
EXP
2,5-hexanedione results in increased expression of NDUFA10 protein 2,5-hexanedione results in decreased expression of NDUFA10 protein
CTD
PMID:19033394
NCBI chr 9:99,617,051...99,651,827
Ensembl chr 9:99,617,052...99,651,813
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Nefh
neurofilament heavy
decreases expression
EXP
2,5-hexanedione results in decreased expression of NEFH protein
CTD
PMID:19033394
NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
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Nefl
neurofilament light
decreases expression multiple interactions
EXP
2,5-hexanedione results in decreased expression of NEFL protein Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of NEFL protein]
CTD
PMID:19033394 PMID:32522579
NCBI chr15:44,799,378...44,803,251
Ensembl chr15:44,799,334...44,804,574
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Nefm
neurofilament medium
decreases expression
EXP
2,5-hexanedione results in decreased expression of NEFM protein
CTD
PMID:19033394
NCBI chr15:44,855,307...44,860,604
Ensembl chr15:44,855,310...44,860,604
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Nlrp3
NLR family, pyrin domain containing 3
multiple interactions increases expression
EXP
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of NLRP3 protein]
CTD
PMID:32522579
NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
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Nos2
nitric oxide synthase 2
increases expression multiple interactions
EXP
2,5-hexanedione results in increased expression of NOS2 mRNA Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of NOS2 mRNA]
CTD
PMID:32522579
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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Nsf
N-ethylmaleimide sensitive factor, vesicle fusing ATPase
decreases expression
EXP
2,5-hexanedione results in decreased expression of NSF protein
CTD
PMID:19033394
NCBI chr10:91,879,608...91,986,242
Ensembl chr10:91,878,633...92,008,082
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Nupr2
nuclear protein 2, transcriptional regulator
increases expression
EXP
2,5-hexanedione results in increased expression of NUPR1L mRNA
CTD
PMID:22952946
NCBI chr12:30,300,936...30,304,041
Ensembl chr12:30,303,725...30,304,036
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Pdia3
protein disulfide isomerase family A, member 3
decreases expression
EXP
2,5-hexanedione results in decreased expression of PDIA3 protein
CTD
PMID:19033394
NCBI chr 3:113,376,983...113,400,707
Ensembl chr 3:113,376,983...113,400,707
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Pdlim3
PDZ and LIM domain 3
decreases expression
EXP
2,5-hexanedione results in decreased expression of PDLIM3 protein
CTD
PMID:19033394
NCBI chr16:49,543,140...49,574,362
Ensembl chr16:49,543,142...49,574,390
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Pgam1
phosphoglycerate mutase 1
increases expression
EXP
2,5-hexanedione results in increased expression of PGAM1 protein
CTD
PMID:19033394
NCBI chr 1:261,158,204...261,165,814
Ensembl chr 1:261,158,261...261,165,808
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Phospho1
phosphoethanolamine/phosphocholine phosphatase 1
increases expression
EXP
2,5-hexanedione results in increased expression of PHOSPHO1 mRNA
CTD
PMID:22952946
NCBI chr10:83,635,557...83,643,862
Ensembl chr10:83,636,518...83,643,859
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Pim1
Pim-1 proto-oncogene, serine/threonine kinase
increases expression
EXP
2,5-hexanedione results in increased expression of PIM1 mRNA
CTD
PMID:22952946
NCBI chr20:8,165,423...8,169,557
Ensembl chr20:8,165,307...8,169,555
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Pkm
pyruvate kinase M1/2
increases expression
EXP
2,5-hexanedione results in increased expression of PKM protein
CTD
PMID:19033394
NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
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Pou2f1
POU class 2 homeobox 1
increases expression
EXP
2,5-hexanedione results in increased expression of POU2F1 mRNA
CTD
PMID:22952946
NCBI chr13:84,075,316...84,217,368
Ensembl chr13:84,083,632...84,217,366
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Prkcsh
protein kinase C substrate 80K-H
decreases expression
EXP
2,5-hexanedione results in decreased expression of PRKCSH protein
CTD
PMID:19033394
NCBI chr 8:23,014,802...23,026,507
Ensembl chr 8:23,014,956...23,026,503
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Ptgds
prostaglandin D2 synthase
increases expression
EXP
2,5-hexanedione results in increased expression of PTGDS mRNA
CTD
PMID:22952946 PMID:27466211
NCBI chr 3:2,686,125...2,689,059
Ensembl chr 3:2,686,123...2,689,084
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Pygb
glycogen phosphorylase B
decreases expression
EXP
2,5-hexanedione results in decreased expression of PYGB protein
CTD
PMID:19033394
NCBI chr 3:146,581,063...146,629,504
Ensembl chr 3:146,582,752...146,634,535
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Pygm
glycogen phosphorylase, muscle associated
decreases expression
EXP
2,5-hexanedione results in decreased expression of PYGM protein
CTD
PMID:19033394
NCBI chr 1:221,756,325...221,771,142
Ensembl chr 1:221,756,286...221,771,143
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Ralgapa2
Ral GTPase activating protein catalytic subunit alpha 2
increases expression
EXP
2,5-hexanedione results in increased expression of RALGAPA2 mRNA
CTD
PMID:22952946
NCBI chr 3:140,451,850...140,728,305
Ensembl chr 3:140,468,701...140,728,129
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
EXP
2,5-hexanedione results in decreased expression of and affects the localization of RELA protein
CTD
PMID:22337490
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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RGD1304694
similar to CG9646-PA
increases expression
EXP
2,5-hexanedione results in increased expression of RGD1304694 mRNA
CTD
PMID:22952946
NCBI chr 7:125,853,573...125,893,168
Ensembl chr 7:125,857,046...125,893,168
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RGD1562608
similar to KIAA1328 protein
increases expression
EXP
2,5-hexanedione results in increased expression of RGD1562608 mRNA
CTD
PMID:22952946
NCBI chr18:17,394,586...17,678,605
Ensembl chr18:17,403,407...17,676,049
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Rtkn2
rhotekin 2
increases expression
EXP
2,5-hexanedione results in increased expression of RTKN2 mRNA
CTD
PMID:22952946
NCBI chr20:21,919,486...22,004,279
Ensembl chr20:21,932,878...22,004,279
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S100z
S100 calcium binding protein Z
increases expression
EXP
2,5-hexanedione results in increased expression of S100Z mRNA
CTD
PMID:22952946
NCBI chr 2:25,188,381...25,203,627
Ensembl chr 2:25,188,782...25,190,495
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Sclt1
sodium channel and clathrin linker 1
increases expression
EXP
2,5-hexanedione results in increased expression of SCLT1 mRNA
CTD
PMID:22952946
NCBI chr 2:128,523,376...128,675,668
Ensembl chr 2:128,523,636...128,675,408
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Septin8
septin 8
decreases expression
EXP
2,5-hexanedione results in decreased expression of SEPTIN8 protein
CTD
PMID:19033394
NCBI chr10:38,877,422...38,906,480
Ensembl chr10:38,877,422...38,906,482
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Sh2d4a
SH2 domain containing 4A
decreases expression
EXP
2,5-hexanedione results in decreased expression of SH2D4A mRNA
CTD
PMID:22952946
NCBI chr16:23,084,247...23,156,825
Ensembl chr16:23,083,954...23,156,962
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Shank3
SH3 and multiple ankyrin repeat domains 3
multiple interactions
EXP
[carbendazim co-treated with 2,5-hexanedione] affects the expression of SHANK3 mRNA
CTD
PMID:22382377
NCBI chr 7:130,474,278...130,534,679
Ensembl chr 7:130,474,279...130,534,679
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Sil1
SIL1 nucleotide exchange factor
increases expression
EXP
2,5-hexanedione results in increased expression of SIL1 mRNA
CTD
PMID:22952946
NCBI chr18:28,067,476...28,302,008
Ensembl chr18:28,067,484...28,301,863
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Slc10a7
solute carrier family 10, member 7
increases expression
EXP
2,5-hexanedione results in increased expression of SLC10A7 mRNA
CTD
PMID:22952946
NCBI chr19:32,857,984...33,081,359
Ensembl chr19:32,855,343...33,080,998
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Sltm
SAFB-like, transcription modulator
increases expression
EXP
2,5-hexanedione results in increased expression of SLTM mRNA
CTD
PMID:22952946
NCBI chr 8:76,977,698...77,022,847
Ensembl chr 8:76,977,822...77,022,837
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Sod3
superoxide dismutase 3
increases expression
EXP
2,5-hexanedione results in increased expression of SOD3 mRNA
CTD
PMID:22952946 PMID:27466211
NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
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Sppl3
signal peptide peptidase like 3
increases expression
EXP
2,5-hexanedione results in increased expression of SPPL3 mRNA
CTD
PMID:22952946
NCBI chr12:47,276,485...47,360,552
Ensembl chr12:47,276,476...47,360,507
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Sptan1
spectrin, alpha, non-erythrocytic 1
decreases expression
EXP
2,5-hexanedione results in decreased expression of SPTAN1 protein
CTD
PMID:19033394
NCBI chr 3:8,534,437...8,599,259
Ensembl chr 3:8,534,440...8,599,260
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Stmn1
stathmin 1
decreases expression
EXP
2,5-hexanedione results in decreased expression of STMN1 mRNA
CTD
PMID:22952946
NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
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Strbp
spermatid perinuclear RNA binding protein
increases expression
EXP
2,5-hexanedione results in increased expression of STRBP mRNA
CTD
PMID:22952946
NCBI chr 3:21,817,680...21,956,988
Ensembl chr 3:21,828,298...21,904,270
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Styxl1
serine/threonine/tyrosine interacting-like 1
increases expression
EXP
2,5-hexanedione results in increased expression of STYXL1 mRNA
CTD
PMID:22952946
NCBI chr12:23,954,563...23,987,155
Ensembl chr12:23,954,574...23,987,271
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Tax1bp1
Tax1 binding protein 1
increases expression
EXP
2,5-hexanedione results in increased expression of TAX1BP1 mRNA
CTD
PMID:22952946
NCBI chr 4:82,776,720...82,832,586
Ensembl chr 4:82,776,746...82,833,773
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Tbc1d5
TBC1 domain family, member 5
increases expression
EXP
2,5-hexanedione results in increased expression of TBC1D5 mRNA
CTD
PMID:22952946
NCBI chr 9:1,144,641...1,747,732
Ensembl chr 9:1,145,700...1,746,397
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Tmem192
transmembrane protein 192
increases expression
EXP
2,5-hexanedione results in increased expression of TMEM192 mRNA
CTD
PMID:22952946
NCBI chr16:26,620,525...26,642,537
Ensembl chr16:26,619,598...26,633,796
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Tnf
tumor necrosis factor
multiple interactions increases expression
EXP
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of TNF mRNA]
CTD
PMID:32522579
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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Tpi1
triosephosphate isomerase 1
increases expression
EXP
2,5-hexanedione results in increased expression of TPI1 mRNA; 2,5-hexanedione results in increased expression of TPI1 protein
CTD
PMID:19033394 PMID:22952946
NCBI chr 4:157,328,375...157,331,905
Ensembl chr 4:157,328,379...157,331,905
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Uba1
ubiquitin-like modifier activating enzyme 1
increases expression
EXP
2,5-hexanedione results in increased expression of UBA1 protein
CTD
PMID:19033394
NCBI chr X:1,723,135...1,745,147
Ensembl chr X:1,723,174...1,741,701
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Ubn2
ubinuclein 2
increases expression
EXP
2,5-hexanedione results in increased expression of UBN2 mRNA
CTD
PMID:22952946
NCBI chr 4:66,164,639...66,254,297
Ensembl chr 4:66,165,845...66,233,230
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Uqcrc2
ubiquinol cytochrome c reductase core protein 2
decreases expression
EXP
2,5-hexanedione results in decreased expression of UQCRC2 mRNA
CTD
PMID:22952946
NCBI chr 1:190,555,177...190,585,741
Ensembl chr 1:190,555,177...190,585,734
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Vim
vimentin
multiple interactions
ISO
2,5-hexanedione promotes the reaction [VIM protein binds to VIM protein]
CTD
PMID:6361548
NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
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Xiap
X-linked inhibitor of apoptosis
decreases expression
EXP
2,5-hexanedione results in decreased expression of XIAP mRNA
CTD
PMID:22337490
NCBI chr X:128,409,425...128,455,786
Ensembl chr X:128,409,472...128,453,000
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Zfp169
zinc finger protein 169
decreases expression
EXP
2,5-hexanedione results in decreased expression of ZFP169 protein
CTD
PMID:19033394
NCBI chr17:16,443,324...16,471,329
Ensembl chr17:16,455,026...16,470,842
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Zfp407
zinc finger protein 407
increases expression
EXP
2,5-hexanedione results in increased expression of ZFP407 mRNA
CTD
PMID:22952946
NCBI chr18:81,057,507...81,453,682
Ensembl chr18:81,057,519...81,428,971
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Akr1b8
aldo-keto reductase family 1, member B8
multiple interactions
EXP
[AKR1B8 protein co-treated with NADP] affects the oxidation of 1-hexanol
CTD
PMID:18845131
NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657
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Acot9
acyl-CoA thioesterase 9
increases methylation
ISO
n-hexanal results in increased methylation of ACOT9 gene
CTD
PMID:30002397
NCBI chr X:43,543,069...43,592,200
Ensembl chr X:43,543,070...43,592,200
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Adh6
alcohol dehydrogenase 6 (class V)
affects expression
EXP
n-hexanal affects the expression of ADH6 mRNA
CTD
PMID:26880647
NCBI chr 2:243,656,568...243,687,857
Ensembl chr 2:243,550,627...243,687,857
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Aire
autoimmune regulator
increases methylation
ISO
n-hexanal results in increased methylation of AIRE gene
CTD
PMID:30002397
NCBI chr20:11,365,630...11,380,636
Ensembl chr20:11,365,697...11,380,631
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Akr1b1
aldo-keto reductase family 1 member B
affects reduction increases reduction
ISO
AKR1B1 protein affects the reduction of n-hexanal; AKR1B1 protein affects the reduction of n-hexanal analog AKR1B1 protein results in increased reduction of n-hexanal
CTD
PMID:9890881 PMID:11306073
NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
G
Akr7a2
aldo-keto reductase family 7, member A2
decreases response to substance
ISO
AKR7A5 protein results in decreased susceptibility to n-hexanal
CTD
PMID:24590062
NCBI chr 5:157,759,448...157,768,473
Ensembl chr 5:157,759,416...157,768,471
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Aldh1a1
aldehyde dehydrogenase 1 family, member A1
increases oxidation
ISO
ALDH1A1 protein results in increased oxidation of n-hexanal
CTD
PMID:23220587
NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
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Aldh1a2
aldehyde dehydrogenase 1 family, member A2
increases oxidation
EXP
ALDH1A2 protein results in increased oxidation of n-hexanal
CTD
PMID:23220587
NCBI chr 8:77,640,234...77,719,488
Ensembl chr 8:77,640,222...77,719,489
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Aldh2
aldehyde dehydrogenase 2 family member
affects metabolic processing
ISO
ALDH2 protein polymorphism affects the metabolism of n-hexanal
CTD
PMID:11744614
NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
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Aldh3a1
aldehyde dehydrogenase 3 family, member A1
affects metabolic processing decreases response to substance
ISO
ALDH3A1 protein affects the metabolism of n-hexanal ALDH3A1 protein results in decreased susceptibility to n-hexanal
CTD
PMID:11306050
NCBI chr10:47,490,168...47,499,855
Ensembl chr10:47,490,153...47,499,876
G
Aldh3b1
aldehyde dehydrogenase 3 family, member B1
affects binding decreases response to substance
ISO
n-hexanal binds to ALDH3B1 protein ALDH3B1 protein results in decreased susceptibility to n-hexanal
CTD
PMID:20699116
NCBI chr 1:219,145,457...219,181,536
Ensembl chr 1:219,145,459...219,186,860
G
Aldh7a1
aldehyde dehydrogenase 7 family, member A1
decreases response to substance
ISO
ALDH7A1 protein results in decreased susceptibility to n-hexanal
CTD
PMID:21338592
NCBI chr18:51,619,007...51,651,267
Ensembl chr18:51,619,007...51,651,267
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B3galt4
Beta-1,3-galactosyltransferase 4
decreases expression
ISO
n-hexanal results in decreased expression of B3GALT4 mRNA
CTD
PMID:25014914
NCBI chr20:5,446,104...5,447,679
Ensembl chr20:5,446,104...5,447,673
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Bmp10
bone morphogenetic protein 10
increases methylation
ISO
n-hexanal results in increased methylation of BMP10 gene
CTD
PMID:30002397
NCBI chr 4:119,224,906...119,230,534
Ensembl chr 4:119,225,040...119,230,728
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Ca9
carbonic anhydrase 9
decreases expression
ISO
n-hexanal results in decreased expression of CA9 mRNA
CTD
PMID:25014914
NCBI chr 5:59,008,277...59,015,535
Ensembl chr 5:59,008,933...59,015,528
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Ccl12
chemokine (C-C motif) ligand 12
affects expression
EXP
n-hexanal affects the expression of CCL12 mRNA
CTD
PMID:26880647
NCBI chr10:69,476,866...69,478,416
Ensembl chr10:69,476,775...69,478,462
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Ccna1
cyclin A1
increases methylation
ISO
n-hexanal results in increased methylation of CCNA1 gene
CTD
PMID:30002397
NCBI chr 2:144,456,689...144,503,570
Ensembl chr 2:144,458,153...144,467,912
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Ccnb1ip1
cyclin B1 interacting protein 1
increases methylation
ISO
n-hexanal results in increased methylation of CCNB1IP1 gene
CTD
PMID:30002397
NCBI chr15:27,720,220...27,736,528
Ensembl chr15:27,720,223...27,733,785
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Cebpd
CCAAT/enhancer binding protein delta
affects expression
EXP
n-hexanal affects the expression of CEBPD mRNA
CTD
PMID:26880647
NCBI chr11:89,008,008...89,009,146
Ensembl chr11:89,008,008...89,009,146
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Cep85
centrosomal protein 85
increases methylation
ISO
n-hexanal results in increased methylation of CEP85 gene
CTD
PMID:30002397
NCBI chr 5:152,359,693...152,406,530
Ensembl chr 5:152,359,700...152,406,518
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Chd3
chromodomain helicase DNA binding protein 3
increases methylation
ISO
n-hexanal results in increased methylation of CHD3 gene
CTD
PMID:30002397
NCBI chr10:55,943,467...55,970,417
Ensembl chr10:55,943,446...55,965,216
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Chga
chromogranin A
increases expression
EXP
n-hexanal results in increased expression of CHGA mRNA
CTD
PMID:26403475
NCBI chr 6:126,434,226...126,445,569
Ensembl chr 6:126,434,226...126,445,568
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Cox17
cytochrome c oxidase copper chaperone COX17
increases methylation
ISO
n-hexanal results in increased methylation of COX17 gene
CTD
PMID:30002397
NCBI chr11:64,962,663...64,968,437
Ensembl chr11:64,962,666...64,968,437
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
ISO
n-hexanal results in increased expression of CYP1A1 mRNA
CTD
PMID:25014914
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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Ddit4
DNA-damage-inducible transcript 4
affects expression
EXP
n-hexanal affects the expression of DDIT4 mRNA
CTD
PMID:26880647
NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
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Dhrs9
dehydrogenase/reductase 9
increases expression
ISO
n-hexanal results in increased expression of DHRS9 mRNA
CTD
PMID:25014914
NCBI chr 3:55,623,671...55,645,883
Ensembl chr 3:55,623,634...55,648,325
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Dnaaf2
dynein, axonemal, assembly factor 2
increases methylation
ISO
n-hexanal results in increased methylation of DNAAF2 gene
CTD
PMID:30002397
NCBI chr 6:91,481,439...91,490,189
Ensembl chr 6:91,481,954...91,490,366
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Hmox1
heme oxygenase 1
decreases expression
ISO
n-hexanal results in decreased expression of HMOX1 mRNA
CTD
PMID:28947239
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
increases methylation
ISO
n-hexanal results in increased methylation of HSD17B11 gene
CTD
PMID:30002397
NCBI chr14:7,054,724...7,104,567
Ensembl chr14:7,073,445...7,104,566
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Jchain
joining chain of multimeric IgA and IgM
increases methylation
ISO
n-hexanal results in increased methylation of JCHAIN gene
CTD
PMID:30002397
NCBI chr14:21,176,841...21,183,731
Ensembl chr14:21,177,237...21,183,542
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Kcnf1
potassium voltage-gated channel modifier subfamily F member 1
increases methylation
ISO
n-hexanal results in increased methylation of KCNF1 gene
CTD
PMID:30002397
NCBI chr 6:42,471,060...42,473,738
Ensembl chr 6:42,471,066...42,473,738
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Kif7
kinesin family member 7
increases methylation
ISO
n-hexanal results in increased methylation of KIF7 gene
CTD
PMID:30002397
NCBI chr 1:141,434,183...141,452,592
Ensembl chr 1:141,434,625...141,451,075
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Klf2
Kruppel-like factor 2
affects expression
EXP
n-hexanal affects the expression of KLF2 mRNA
CTD
PMID:26880647
NCBI chr16:19,223,087...19,225,037
Ensembl chr16:19,223,087...19,225,037
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Lhfpl3
LHFPL tetraspan subfamily member 3
increases methylation
ISO
n-hexanal results in increased methylation of LHFPL3 gene
CTD
PMID:30002397
NCBI chr 4:8,537,590...8,994,097
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LOC100911842
uncharacterized LOC100911842
decreases methylation
ISO
n-hexanal results in decreased methylation of C9ORF57 gene
CTD
PMID:30002397
NCBI chr 1:239,150,948...239,156,067
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Lrrc74a
leucine rich repeat containing 74A
increases methylation
ISO
n-hexanal results in increased methylation of LRRC74A gene
CTD
PMID:30002397
NCBI chr 6:110,681,551...110,776,904
Ensembl chr 6:110,749,705...110,776,775
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Mfn1
mitofusin 1
increases methylation
ISO
n-hexanal results in increased methylation of MFN1 gene
CTD
PMID:30002397
NCBI chr 2:118,929,738...118,971,689
Ensembl chr 2:118,929,738...118,973,698
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Mir101a
microRNA 101a
decreases expression
EXP
n-hexanal results in decreased expression of MIR101A mRNA
CTD
PMID:26403475
NCBI chr 5:120,168,437...120,168,511
Ensembl chr 5:120,168,433...120,168,515
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Mir1224
microRNA 1224
decreases expression
EXP
n-hexanal results in decreased expression of MIR1224 mRNA
CTD
PMID:26403475
NCBI chr11:83,992,628...83,992,712
Ensembl chr11:83,992,628...83,992,712
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Mir1249
microRNA 1249
decreases expression
EXP
n-hexanal results in decreased expression of MIR1249 mRNA
CTD
PMID:26403475
NCBI chr 7:125,861,192...125,861,311
Ensembl chr 7:125,861,192...125,861,311
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Mir128-1
microRNA 128-1
increases methylation
ISO
n-hexanal results in increased methylation of MIR128-1 gene
CTD
PMID:30002397
NCBI chr13:44,916,534...44,916,615
Ensembl chr13:44,916,534...44,916,615
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Mir1306
microRNA 1306
decreases expression
EXP
n-hexanal results in decreased expression of MIR1306 mRNA
CTD
PMID:26403475
NCBI chr11:86,857,633...86,857,705
Ensembl chr11:86,857,632...86,857,711
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Mir132
microRNA 132
increases expression
EXP
n-hexanal results in increased expression of MIR132 mRNA
CTD
PMID:26403475
NCBI chr10:62,014,995...62,015,095
Ensembl chr10:62,014,995...62,015,095
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Mir136
microRNA 136
decreases expression
EXP
n-hexanal results in decreased expression of MIR136 mRNA
CTD
PMID:26403475
NCBI chr 6:133,716,761...133,716,842
Ensembl chr 6:133,716,761...133,716,842
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Mir145
microRNA 145
decreases expression
EXP
n-hexanal results in decreased expression of MIR145 mRNA
CTD
PMID:26403475
NCBI chr18:56,969,907...56,969,994
Ensembl chr18:56,969,907...56,969,994
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Mir153
microRNA 153
decreases expression
EXP
n-hexanal results in decreased expression of MIR153 mRNA
CTD
PMID:26403475
NCBI chr 6:145,105,064...145,105,150
Ensembl chr 6:145,105,064...145,105,150
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Mir181b1
microRNA 181b-1
decreases expression
EXP
n-hexanal results in decreased expression of MIR181B1 mRNA
CTD
PMID:26403475
NCBI chr13:54,952,903...54,953,012
Ensembl chr13:54,952,903...54,953,012
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Mir184
microRNA 184
decreases expression
EXP
n-hexanal results in decreased expression of MIR184 mRNA
CTD
PMID:26403475
NCBI chr 8:97,175,657...97,175,733
Ensembl chr 8:97,175,657...97,175,733
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Mir188
microRNA 188
decreases expression
EXP
n-hexanal results in decreased expression of MIR188 mRNA
CTD
PMID:26403475
NCBI chr X:16,110,270...16,110,349
Ensembl chr X:16,110,270...16,110,349
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Mir190
microRNA 190
decreases expression
EXP
n-hexanal results in decreased expression of MIR190 mRNA
CTD
PMID:26403475
NCBI chr 8:73,030,047...73,030,131
Ensembl chr 8:73,030,047...73,030,131
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Mir193a
microRNA 193a
decreases expression
EXP
n-hexanal results in decreased expression of MIR193A mRNA
CTD
PMID:26403475
NCBI chr10:67,065,885...67,065,996
Ensembl chr10:67,065,885...67,065,996
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Mir200a
microRNA 200a
decreases expression
EXP
n-hexanal results in decreased expression of MIR200A mRNA
CTD
PMID:26403475
NCBI chr 5:173,489,366...173,489,454
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Mir217
microRNA 217
decreases expression
EXP
n-hexanal results in decreased expression of MIR217 mRNA
CTD
PMID:26403475
NCBI chr14:113,119,529...113,119,633
Ensembl chr14:113,119,529...113,119,633
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Mir221
microRNA 221
decreases expression
EXP
n-hexanal results in decreased expression of MIR221 mRNA
CTD
PMID:26403475
NCBI chr X:3,684,480...3,684,588
Ensembl chr X:3,684,480...3,684,588
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Mir224
microRNA 224
decreases expression
EXP
n-hexanal results in decreased expression of MIR224 mRNA
CTD
PMID:26403475
NCBI chr X:152,223,754...152,223,835
Ensembl chr X:152,223,754...152,223,835
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Mir290
microRNA 290
decreases expression
EXP
n-hexanal results in decreased expression of MIR292 mRNA
CTD
PMID:26403475
NCBI chr 1:64,538,705...64,538,785
Ensembl chr 1:64,538,705...64,538,785
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Mir299b
microRNA 299b
decreases expression
EXP
n-hexanal results in decreased expression of MIR299 mRNA
CTD
PMID:26403475
NCBI chr 6:133,859,295...133,859,412
Ensembl chr 6:133,859,295...133,859,412
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Mir29b2
microRNA 29b-2
decreases expression
EXP
n-hexanal results in decreased expression of MIR29B2 mRNA
CTD
PMID:26403475
NCBI chr13:113,782,057...113,782,137
Ensembl chr13:113,782,057...113,782,140
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Mir326
microRNA 326
decreases expression
EXP
n-hexanal results in decreased expression of MIR326 mRNA
CTD
PMID:26403475
NCBI chr 1:164,518,401...164,518,495
Ensembl chr 1:164,518,401...164,518,495
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Mir328b
microRNA 328b
decreases expression
EXP
n-hexanal results in decreased expression of MIR328B mRNA
CTD
PMID:26403475
NCBI chr14:45,331,146...45,331,263
Ensembl chr14:45,331,146...45,331,263
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Mir337
microRNA 337
decreases expression
EXP
n-hexanal results in decreased expression of MIR337 mRNA
CTD
PMID:26403475
NCBI chr 6:133,705,920...133,706,016
Ensembl chr 6:133,705,920...133,706,016
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Mir3568
microRNA 3568
decreases expression
EXP
n-hexanal results in decreased expression of MIR3568 mRNA
CTD
PMID:26403475
NCBI chr10:10,855,034...10,855,134
Ensembl chr10:10,855,034...10,855,134
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Mir3582
microRNA 3582
decreases expression
EXP
n-hexanal results in decreased expression of MIR3582 mRNA
CTD
PMID:26403475
NCBI chr18:2,052,459...2,052,576
Ensembl chr18:2,052,459...2,052,576
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Mir3585
microRNA 3585
decreases expression
EXP
n-hexanal results in decreased expression of MIR3585 mRNA
CTD
PMID:26403475
NCBI chr X:155,344,176...155,344,293
Ensembl chr X:155,344,176...155,344,293
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Mir3594
microRNA 3594
decreases expression
EXP
n-hexanal results in decreased expression of MIR3594 mRNA
CTD
PMID:26403475
NCBI chr10:109,244,637...109,244,701
Ensembl chr10:109,244,637...109,244,701
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Mir381
microRNA 381
decreases expression
EXP
n-hexanal results in decreased expression of MIR381 mRNA
CTD
PMID:26403475
NCBI chr 6:133,876,615...133,876,675
Ensembl chr 6:133,876,586...133,876,693
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Mir411
microRNA 411
decreases expression
EXP
n-hexanal results in decreased expression of MIR411 mRNA
CTD
PMID:26403475
NCBI chr 6:133,858,849...133,858,924
Ensembl chr 6:133,858,844...133,858,939
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Mir425
microRNA 425
decreases expression
EXP
n-hexanal results in decreased expression of MIR425 mRNA
CTD
PMID:26403475
NCBI chr 8:117,354,821...117,354,903
Ensembl chr 8:117,354,821...117,354,903
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Mir431
microRNA 431
decreases expression
EXP
n-hexanal results in decreased expression of MIR431 mRNA
CTD
PMID:26403475
NCBI chr 6:133,711,425...133,711,538
Ensembl chr 6:133,711,425...133,711,538
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Mir433
microRNA 433
decreases expression
EXP
n-hexanal results in decreased expression of MIR433 mRNA
CTD
PMID:26403475
NCBI chr 6:133,712,334...133,712,426
Ensembl chr 6:133,712,334...133,712,426
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Mir541
microRNA 541
decreases expression
EXP
n-hexanal results in decreased expression of MIR541 mRNA
CTD
PMID:26403475
NCBI chr 6:133,892,655...133,892,744
Ensembl chr 6:133,892,655...133,892,744
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Mir6315
microRNA 6315
decreases expression
EXP
n-hexanal results in decreased expression of MIR6315 mRNA
CTD
PMID:26403475
NCBI chr 1:221,433,993...221,434,093
Ensembl chr 1:221,433,993...221,434,093
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Mir6317-1
microRNA mir-6317-1
decreases expression
EXP
n-hexanal results in decreased expression of MIR6317-1 mRNA
CTD
PMID:26403475
Ensembl chr 1:259,665,468...259,665,594 Ensembl chr 1:259,665,468...259,665,594
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Mir6332
microRNA 6332
decreases expression
EXP
n-hexanal results in decreased expression of MIR6332 mRNA
CTD
PMID:26403475
NCBI chr 5:167,402,968...167,403,088
Ensembl chr 5:167,402,968...167,403,088
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Mir664-2
microRNA 664-2
decreases expression
EXP
n-hexanal results in decreased expression of MIR664-2 mRNA
CTD
PMID:26403475
NCBI chr13:103,192,581...103,192,639
Ensembl chr13:103,192,581...103,192,639
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Mir7b
microRNA 7b
decreases expression
EXP
n-hexanal results in decreased expression of MIR7B mRNA
CTD
PMID:26403475
NCBI chr 9:10,812,432...10,812,541
Ensembl chr 9:10,812,432...10,812,541
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Mirlet7f1
microRNA let-7f-1
decreases expression
EXP
n-hexanal results in decreased expression of MIRLET7F-1 mRNA
CTD
PMID:26403475
NCBI chr17:16,418,217...16,418,313
Ensembl chr17:16,418,217...16,418,313
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Mmp9
matrix metallopeptidase 9
increases secretion
ISO
n-hexanal results in increased secretion of MMP9 protein
CTD
PMID:28947239
NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
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Mrps18a
mitochondrial ribosomal protein S18A
increases methylation
ISO
n-hexanal results in increased methylation of MRPS18A gene
CTD
PMID:30002397
NCBI chr 9:17,238,354...17,254,845
Ensembl chr 9:17,238,385...17,254,949
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Myc
MYC proto-oncogene, bHLH transcription factor
decreases expression
ISO
n-hexanal results in decreased expression of MYC mRNA
CTD
PMID:12921975
NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
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Myt1
myelin transcription factor 1
increases methylation
ISO
n-hexanal results in increased methylation of MYT1 gene
CTD
PMID:30002397
NCBI chr 3:177,281,365...177,341,550
Ensembl chr 3:177,310,753...177,341,547
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Nfxl1
nuclear transcription factor, X-box binding-like 1
increases methylation
ISO
n-hexanal results in increased methylation of NFXL1 gene
CTD
PMID:30002397
NCBI chr14:38,192,462...38,233,852
Ensembl chr14:38,192,446...38,233,852
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Nmbr
neuromedin B receptor
increases methylation
ISO
n-hexanal results in increased methylation of NMBR gene
CTD
PMID:30002397
NCBI chr 1:8,933,744...8,945,850
Ensembl chr 1:8,933,831...8,944,987
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Nuf2
NUF2 component of NDC80 kinetochore complex
increases methylation
ISO
n-hexanal results in increased methylation of NUF2 gene
CTD
PMID:30002397
NCBI chr13:87,818,456...87,847,223
Ensembl chr13:87,818,391...87,847,263
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Olr1597
olfactory receptor 1597
increases methylation
ISO
n-hexanal results in increased methylation of OR10Z1 gene
CTD
PMID:30002397
NCBI chr13:92,342,255...92,343,196
Ensembl chr13:92,342,255...92,343,196
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Pcdha10
protocadherin alpha 10
increases methylation
ISO
n-hexanal results in increased methylation of PCDHA10 gene
CTD
PMID:30002397
NCBI chr18:30,010,918...30,215,896
Ensembl chr18:29,987,206...30,215,897
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Pcdha9
protocadherin alpha 9
increases methylation
ISO
n-hexanal results in increased methylation of PCDHA9 gene
CTD
PMID:30002397
NCBI chr18:30,004,565...30,215,897
Ensembl chr18:29,987,206...30,215,897
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Pde4a
phosphodiesterase 4A
increases methylation
ISO
n-hexanal results in increased methylation of PDE4A gene
CTD
PMID:30002397
NCBI chr 8:22,189,533...22,234,036
Ensembl chr 8:22,189,600...22,233,748
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Pex2
peroxisomal biogenesis factor 2
increases methylation
ISO
n-hexanal results in increased methylation of PEX2 gene
CTD
PMID:30002397
NCBI chr 2:98,251,756...98,269,185
Ensembl chr 2:98,252,925...98,269,184
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Phactr1
phosphatase and actin regulator 1
increases methylation
ISO
n-hexanal results in increased methylation of PHACTR1 gene
CTD
PMID:30002397
NCBI chr17:23,245,423...23,761,207
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Pik3c2a
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
increases methylation
ISO
n-hexanal results in increased methylation of PIK3C2A gene
CTD
PMID:30002397
NCBI chr 1:185,210,922...185,326,314
Ensembl chr 1:185,210,922...185,326,314
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Plppr5
phospholipid phosphatase related 5
increases methylation
ISO
n-hexanal results in increased methylation of PLPPR5 gene
CTD
PMID:30002397
NCBI chr 2:219,895,141...220,102,333
Ensembl chr 2:219,896,765...220,101,791
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Prkacb
protein kinase cAMP-activated catalytic subunit beta
increases methylation
ISO
n-hexanal results in increased methylation of PRKACB gene
CTD
PMID:30002397
NCBI chr 2:252,602,197...252,691,886
Ensembl chr 2:252,605,307...252,691,886
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Reg1a
regenerating family member 1 alpha
increases methylation
ISO
n-hexanal results in increased methylation of REG1A gene
CTD
PMID:30002397
NCBI chr 4:109,497,962...109,500,626
Ensembl chr 4:109,497,962...109,501,082
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Scarna3
small Cajal body-specific RNA 3
decreases expression
EXP
n-hexanal results in decreased expression of SCARNA3 mRNA
CTD
PMID:26403475
NCBI chr 6:103,567,572...103,567,661
Ensembl chr 6:103,567,572...103,567,661
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Slc39a5
solute carrier family 39 member 5
decreases expression
ISO
n-hexanal results in decreased expression of SLC39A5 mRNA
CTD
PMID:25014914
NCBI chr 7:2,813,875...2,819,917
Ensembl chr 7:2,813,875...2,819,299
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Slk
STE20-like kinase
increases methylation
ISO
n-hexanal results in increased methylation of SLK gene
CTD
PMID:30002397
NCBI chr 1:267,359,761...267,415,735
Ensembl chr 1:267,359,830...267,412,810
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Snca
synuclein alpha
increases methylation
ISO
n-hexanal results in increased methylation of SNCA gene
CTD
PMID:30002397
NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
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Snora58
small nucleolar RNA, H/ACA box 58
decreases expression
EXP
n-hexanal results in decreased expression of SNORA58 mRNA
CTD
PMID:26403475
NCBI chr 6:111,468,732...111,468,807
Ensembl chr 6:111,468,732...111,468,807
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Spink4
serine peptidase inhibitor, Kazal type 4
increases methylation
ISO
n-hexanal results in increased methylation of SPINK4 gene
CTD
PMID:30002397
NCBI chr 5:57,238,221...57,252,654
Ensembl chr 5:57,239,086...57,250,662
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Stpg4
sperm-tail PG-rich repeat containing 4
increases methylation
ISO
n-hexanal results in increased methylation of STPG4 gene
CTD
PMID:30002397
NCBI chr 6:11,014,596...11,063,509
Ensembl chr 6:11,022,034...11,063,092
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Tdrkh
tudor and KH domain containing
increases methylation
ISO
n-hexanal results in increased methylation of TDRKH gene
CTD
PMID:30002397
NCBI chr 2:195,649,813...195,674,217
Ensembl chr 2:195,651,930...195,674,616
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Thumpd3
THUMP domain containing 3
increases methylation
ISO
n-hexanal results in increased methylation of THUMPD3 gene
CTD
PMID:30002397
NCBI chr 4:144,985,850...145,010,164
Ensembl chr 4:144,985,880...145,008,831
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Tnf
tumor necrosis factor
increases expression
ISO
n-hexanal results in increased expression of TNF mRNA
CTD
PMID:28947239
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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Tp53
tumor protein p53
decreases expression
ISO
n-hexanal results in decreased expression of TP53 mRNA
CTD
PMID:12921975
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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Trim27
tripartite motif-containing 27
increases methylation
ISO
n-hexanal results in increased methylation of TRIM27 gene
CTD
PMID:30002397
NCBI chr17:45,613,863...45,626,212
Ensembl chr17:45,613,864...45,626,212
G
Ubxn4
UBX domain protein 4
increases methylation
ISO
n-hexanal results in increased methylation of UBXN4 gene
CTD
PMID:30002397
NCBI chr13:44,956,963...44,989,653
Ensembl chr13:44,957,014...44,990,535
G
Wdr75
WD repeat domain 75
increases methylation
ISO
n-hexanal results in increased methylation of WDR75 gene
CTD
PMID:30002397
NCBI chr 9:52,687,845...52,717,808
Ensembl chr 9:52,687,868...52,717,809
G
Zfhx2
zinc finger homeobox 2
increases methylation
ISO
n-hexanal results in increased methylation of ZFHX2 gene
CTD
PMID:30002397
NCBI chr15:33,719,313...33,752,665
Ensembl chr15:33,720,701...33,752,665
G
Adgrl3
adhesion G protein-coupled receptor L3
increases abundance
ISO
ADGRL3 gene modified form results in increased abundance of 1,6-diaminohexane
CTD
PMID:25445006
NCBI chr14:28,362,176...29,226,085
Ensembl chr14:28,393,394...28,967,980
G
Scara5
scavenger receptor class A, member 5
increases abundance
ISO
SCARA5 gene modified form results in increased abundance of 1,6-diaminohexane
CTD
PMID:25445006
NCBI chr15:49,069,142...49,177,159
Ensembl chr15:49,069,145...49,177,166
G
Ppara
peroxisome proliferator activated receptor alpha
affects binding
ISO
mono-n-hexyl phthalate binds to PPARA protein
CTD
PMID:23843199
NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
G
Ppard
peroxisome proliferator-activated receptor delta
affects binding
ISO
mono-n-hexyl phthalate binds to PPARB protein
CTD
PMID:23843199
NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
G
Pparg
peroxisome proliferator-activated receptor gamma
affects binding
ISO
mono-n-hexyl phthalate binds to PPARG protein
CTD
PMID:23843199
NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
19853
role
19804
biological role
19804
aetiopathogenetic role
18987
neurotoxin
17617
hexane
425
1-iminohexane-2,3,4,5-tetrol
0
1-isothiocyanato-6-(methylsulfanyl)hexane
0
1-nitrohexane
0
2,3,5-trimethylhexane
0
2,4-dimethylhexane
0
2,5-hexanedione
189
3-hexanone
0
3-mercaptohexanol +
0
3-methoxy-3-methylhexane
0
5-iminohexane-1,2,3,4,6-pentol
0
7-(methylthio)heptanonitrile oxide
0
hexanal
108
hexane-1,6-diamine +
2
hexane-1,6-diol +
0
hexane-2,5-diol
0
hexanol +
4
hexyl group
0
perfluorohexane
0
Path 2
CHEBI ontology
19853
subatomic particle
19851
composite particle
19851
hadron
19851
baryon
19851
nucleon
19851
atomic nucleus
19851
atom
19851
main group element atom
19744
main group molecular entity
19744
s-block molecular entity
19491
hydrogen molecular entity
19483
hydrides
18748
organic hydride
18302
organic fundamental parent
18302
hydrocarbon
18030
alkane
13713
hexane
425
1-iminohexane-2,3,4,5-tetrol
0
1-isothiocyanato-6-(methylsulfanyl)hexane
0
1-nitrohexane
0
2,3,5-trimethylhexane
0
2,4-dimethylhexane
0
2,5-hexanedione
189
3-hexanone
0
3-mercaptohexanol +
0
3-methoxy-3-methylhexane
0
5-iminohexane-1,2,3,4,6-pentol
0
7-(methylthio)heptanonitrile oxide
0
hexanal
108
hexane-1,6-diamine +
2
hexane-1,6-diol +
0
hexane-2,5-diol
0
hexanol +
4
hexyl group
0
perfluorohexane
0