CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: fusidic acid
Accession: CHEBI:29013
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Definition: A steroid antibiotic that is isolated from the fermentation broth of Fusidium coccineum.
Synonyms: exact_synonym: (2Z)-2-[(17Z)-16beta-acetoxy-3alpha,11alpha-dihydroxy-4alpha,8alpha,10,14beta-tetramethyl-5alpha,9beta,13alpha-gonan-17-ylidene]-6-methylhept-5-enoic acid
related_synonym: Formula=C31H48O6; Fucidin acid; Fusidine; InChI=1S/C31H48O6/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36)/b26-20-/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-/m0/s1; InChIKey=IECPWNUMDGFDKC-MZJAQBGESA-N; Ramycin; SMILES=[H][C@@]12CC[C@@]3(C)[C@@]([H])([C@H](O)C[C@@]4([H])\\C([C@H](C[C@]34C)OC(C)=O)=C(/CCC=C(C)C)C(O)=O)[C@@]1(C)CC[C@@H](O)[C@H]2C; fucidic acid
alt_id: CHEBI:24133; CHEBI:42742; CHEBI:5201
xref: Beilstein:2197692; Beilstein:5672885; CAS:6990-06-3; DrugBank:DB02703; Drug_Central:1261; HMDB:HMDB0015570; KEGG:C06694; KEGG:D04281; KNApSAcK:C00023903; LIPID_MAPS_instance:LMPR0106040001
xref_mesh: MESH:D005672
xref: MetaCyc:CPD0-1606; PDBeChem:FUA; PMID:11412963; PMID:12937375; PMID:13899435; PMID:13996455; PMID:15843024; PMID:17082187; PMID:20797618; PMID:22066960; PMID:22100514; PMID:22197537; PMID:22290345; PMID:22308410; PMID:22354299; PMID:22612900; PMID:22645663; PMID:22888356; PMID:23102978; PMID:23114758; PMID:23147726; PMID:8624493; Reaxys:2197692; VSDB:1776; Wikipedia:Fusidic_acid
cyclic_relationship: is_conjugate_acid_of CHEBI:71321
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Abcb11
ATP binding cassette subfamily B member 11
decreases activity multiple interactions
EXP ISO
Fusidic Acid results in decreased activity of ABCB11 protein Fusidic Acid inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD
PMID:12106615 PMID:20829430 PMID:23956101 PMID:24014644 PMID:27676153
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Abcb1a
ATP binding cassette subfamily B member 1A
multiple interactions
ISO
Fusidic Acid inhibits the reaction [ABCB1 protein results in increased export of Digoxin]
CTD
PMID:26888941
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcc2
ATP binding cassette subfamily C member 2
multiple interactions
EXP
Fusidic Acid results in decreased expression of and results in decreased activity of ABCC2 protein
CTD
PMID:12106615
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions
ISO
Fusidic Acid inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]
CTD
PMID:26888941
NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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Slc10a1
solute carrier family 10 member 1
multiple interactions
ISO
Fusidic Acid inhibits the reaction [SLC10A1 protein results in increased transport of Taurocholic Acid]
CTD
PMID:27676153
NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
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Slco1a4
solute carrier organic anion transporter family, member 1a4
multiple interactions
EXP
Fusidic Acid inhibits the reaction [SLCO1A4 protein results in increased uptake of Rosuvastatin Calcium]
CTD
PMID:26888941
NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
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Slco1b2
solute carrier organic anion transporter family member 1B2
multiple interactions decreases activity
EXP ISO
Fusidic Acid inhibits the reaction [SLCO1B2 protein results in increased uptake of Rosuvastatin Calcium] Fusidic Acid inhibits the reaction [SLCO1B3 protein results in increased uptake of Rosuvastatin Calcium] Fusidic Acid results in decreased activity of SLCO1B3 protein
CTD
PMID:26888941 PMID:27676153
NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
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Ugt1a1
UDP glucuronosyltransferase family 1 member A1
multiple interactions
ISO
Fusidic Acid inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Estradiol]
CTD
PMID:27676153
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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