Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:strychnine
go back to main search page
Accession:CHEBI:28973 term browser browse the term
Definition:A monoterpenoid indole alkaloid that is strychnidine bearing a keto substituent at the 10-position.
Synonyms:exact_synonym: strychnidin-10-one
 related_synonym: Formula=C21H22N2O2;   InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1;   InChIKey=QMGVPVSNSZLJIA-FVWCLLPLSA-N;   SMILES=[H][C@@]12CC(=O)N3c4ccccc4[C@]45CCN6CC(=CCO1)[C@]([H])(C[C@@]46[H])[C@]2([H])[C@]35[H];   Strychnin
 alt_id: CHEBI:26795;   CHEBI:9293
 xref: BPDB:2066;   Beilstein:52979;   CAS:57-24-9;   Drug_Central:2484;   Gmelin:117894;   KEGG:C06522;   KNApSAcK:C00001770;   KNApSAcK:C00025213
 xref_mesh: MESH:D013331
 xref: PDBeChem:SY9;   PMID:10471592;   PMID:10821054;   PMID:11024105;   PMID:11157095;   PMID:11324564;   PMID:11327524;   PMID:11453337;   PMID:11516560;   PMID:11900860;   PMID:12611967;   PMID:12718443;   PMID:12742643;   PMID:12757728;   PMID:14530208;   PMID:14552874;   PMID:14575889;   PMID:15046720;   PMID:15275654;   PMID:15302677;   PMID:15601738;   PMID:15610168;   PMID:16075189;   PMID:16171972;   PMID:16887371;   PMID:16950410;   PMID:17145135;   PMID:17365101;   PMID:17449162;   PMID:17595105;   PMID:17827655;   PMID:17900376;   PMID:18199816;   PMID:19071748;   PMID:19194159;   PMID:19200346;   PMID:19394327;   PMID:19445923;   PMID:19617896;   PMID:19628662;   PMID:20534469;   PMID:20810461;   PMID:20837125;   PMID:21042643;   PMID:21109870;   PMID:21468359;   PMID:21506420;   PMID:21532268;   PMID:21616062;   PMID:21618309;   PMID:21666516;   PMID:21726589;   PMID:22168233;   PMID:22417832;   PMID:23395890;   PMID:25702781;   PMID:25877308;   PMID:25958869;   PMID:26028680;   PMID:26173662;   PMID:26223366;   PMID:26330182;   PMID:26416729;   PMID:26556179;   PMID:26625339;   PMID:9918589;   Reaxys:52979;   Wikipedia:Strychnine
 cyclic_relationship: is_conjugate_base_of CHEBI:90700


show annotations for term's descendants           Sort by:
 
strychnine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases expression EXP Strychnine results in increased expression of CASP3 mRNA CTD PMID:19815060 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 affects binding
multiple interactions
ISO Strychnine binds to CHRM2 protein
Strychnine promotes the reaction [N-Methylscopolamine binds to CHRM2 protein]
CTD PMID:9495826 PMID:15647330 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 affects binding EXP
ISO
Strychnine binds to CHRM3 protein CTD PMID:12435818 PMID:15647330 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 multiple interactions ISO Strychnine promotes the reaction [N-Methylscopolamine binds to CHRM4 protein] CTD PMID:9495826 NCBI chr 3:80,833,272...80,841,165
Ensembl chr 3:80,833,272...80,841,006
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP Strychnine results in increased expression of and results in increased degradation of CYP2B1 protein CTD PMID:7906730 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Strychnine results in increased expression of CYP2B2 protein CTD PMID:7906730 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Gfap glial fibrillary acidic protein increases expression EXP Strychnine results in increased expression of GFAP mRNA CTD PMID:22954530 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Glra1 glycine receptor, alpha 1 multiple interactions
decreases activity
ISO
EXP
Strychnine analog binds to and results in decreased activity of GLRA1 protein; Strychnine binds to and results in decreased activity of GLRA1 protein; Strychnine promotes the reaction [Genistein results in decreased activity of GLRA1 protein]; Strychnine promotes the reaction [Quercetin results in decreased activity of GLRA1 protein]
Strychnine results in decreased activity of GLRA1 protein
Genistein promotes the reaction [Strychnine results in decreased activity of GLRA1 protein]; Quercetin promotes the reaction [Strychnine results in decreased activity of GLRA1 protein]
CTD PMID:7752562 PMID:15081878 PMID:16687139 PMID:20719748 NCBI chr10:40,851,955...40,954,364
Ensembl chr10:40,855,559...40,953,651
JBrowse link
G Glra2 glycine receptor, alpha 2 decreases activity EXP Strychnine results in decreased activity of GLRA2 protein CTD PMID:7752562 NCBI chr  X:30,612,894...30,832,078
Ensembl chr  X:30,612,903...30,831,483
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Strychnine inhibits the reaction [NAD inhibits the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased secretion of IL1B protein]] CTD PMID:29642561 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Strychnine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 multiple interactions ISO Strychnine binds to and results in decreased activity of SCN5A protein CTD PMID:21616062 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Strychnine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19817
    role 19767
      application 19445
        pesticide 16593
          rodenticide 5964
            strychnine 13
              2-hydroxy-3-methoxystrychnine 0
              alpha-colubrine 0
              beta-colubrine 0
              pseudostrychnine 0
              strychnine N-oxide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19817
    subatomic particle 19815
      composite particle 19815
        hadron 19815
          baryon 19815
            nucleon 19815
              atomic nucleus 19815
                atom 19815
                  main group element atom 19705
                    p-block element atom 19705
                      carbon group element atom 19614
                        carbon atom 19603
                          organic molecular entity 19603
                            organic group 18537
                              cyclic organic group 1849
                                organic heterobicyclic ring 1849
                                  indole skeleton 1849
                                    indole alkaloid 1849
                                      terpenoid indole alkaloid 1468
                                        monoterpenoid indole alkaloid 1458
                                          strychnidine 13
                                            strychnine 13
                                              2-hydroxy-3-methoxystrychnine 0
                                              alpha-colubrine 0
                                              beta-colubrine 0
                                              pseudostrychnine 0
                                              strychnine N-oxide 0
paths to the root