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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:astemizole
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Accession:CHEBI:2896 term browser browse the term
Definition:A piperidine compound having a 2-(4-methoxyphenyl)ethyl group at the 1-position and an N-[(4-fluorobenzyl)benzimidazol-2-yl]amino group at the 4-position.
Synonyms:exact_synonym: 1-(4-fluorobenzyl)-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine
 related_synonym: 1-(p-Fluorobenzyl)-2-((1-(2-(p-methoxyphenyl)ethyl)piperid-4-yl)amino)benzimidazole;   1-(p-Fluorobenzyl)-2-((1-(p-methoxyphenethyl)-4-piperidyl)amino)benzimidazole;   Astemison;   Formula=C28H31FN4O;   InChI=1S/C28H31FN4O/c1-34-25-12-8-21(9-13-25)14-17-32-18-15-24(16-19-32)30-28-31-26-4-2-3-5-27(26)33(28)20-22-6-10-23(29)11-7-22/h2-13,24H,14-20H2,1H3,(H,30,31);   InChIKey=GXDALQBWZGODGZ-UHFFFAOYSA-N;   SMILES=COc1ccc(CCN2CCC(CC2)Nc2nc3ccccc3n2Cc2ccc(F)cc2)cc1;   astemizol;   astemizolum
 xref: Beilstein:4830190;   CAS:68844-77-9;   DrugBank:DB00637;   Drug_Central:249;   KEGG:C06832;   KEGG:D00234;   LINCS:LSM-5502
 xref_mesh: MESH:D016589
 xref: Patent:EP5318;   Patent:US4219559


show annotations for term's descendants           Sort by:
astemizole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity		 ISO Astemizole inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Astemizole results in decreased activity of ABCB11 protein		 CTD PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Ak3 adenylate kinase 3 increases expression EXP Astemizole results in increased expression of AK3 mRNA CTD PMID:20221588 NCBI chr 1:226,737,472...226,764,647
Ensembl chr 1:226,739,318...226,764,625 		JBrowse link
G Alas2 5'-aminolevulinate synthase 2 increases expression EXP Astemizole results in increased expression of ALAS2 mRNA CTD PMID:20221588 NCBI chr  X:19,463,146...19,486,526
Ensembl chr  X:19,463,171...19,486,519 		JBrowse link
G Angpt2 angiopoietin 2 increases expression EXP Astemizole results in increased expression of ANGPT2 mRNA CTD PMID:20221588 NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Astemizole results in increased expression of ATF3 mRNA CTD PMID:32661532 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 increases expression EXP Astemizole results in increased expression of ATP1B1 mRNA CTD PMID:20221588 NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459 		JBrowse link
G Atp1b2 ATPase Na+/K+ transporting subunit beta 2 decreases expression EXP Astemizole results in decreased expression of ATP1B2 mRNA CTD PMID:20221588 NCBI chr10:54,318,698...54,324,933
Ensembl chr10:54,318,701...54,324,933 		JBrowse link
G Atp5f1e ATP synthase F1 subunit epsilon increases expression EXP Astemizole results in increased expression of ATP5F1E mRNA CTD PMID:20221588 NCBI chr 3:163,259,072...163,261,974
Ensembl chr 3:163,260,476...163,261,450 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression EXP Astemizole results in decreased expression of BCL2 mRNA CTD PMID:20221588 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bmp1 bone morphogenetic protein 1 decreases expression EXP Astemizole results in decreased expression of BMP1 mRNA CTD PMID:20221588 NCBI chr15:45,551,603...45,595,862
Ensembl chr15:45,551,603...45,595,776 		JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II delta decreases expression EXP Astemizole results in decreased expression of CAMK2D mRNA CTD PMID:20221588 NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178 		JBrowse link
G Cat catalase increases expression EXP Astemizole results in increased expression of CAT mRNA CTD PMID:20221588 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl7 C-C motif chemokine ligand 7 decreases expression EXP Astemizole results in decreased expression of CCL7 mRNA CTD PMID:20221588 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression EXP Astemizole results in increased expression of CEBPB mRNA CTD PMID:20221588 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Cebpg CCAAT/enhancer binding protein gamma decreases expression EXP Astemizole results in decreased expression of CEBPG mRNA CTD PMID:20221588 NCBI chr 1:87,683,060...87,692,772
Ensembl chr 1:87,684,019...87,694,569 		JBrowse link
G Cfh complement factor H decreases expression EXP Astemizole results in decreased expression of CFH mRNA CTD PMID:20221588 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838 		JBrowse link
G Colec12 collectin sub-family member 12 decreases expression EXP Astemizole results in decreased expression of COLEC12 mRNA CTD PMID:20221588 NCBI chr18:732,950...920,620
Ensembl chr18:732,950...920,618 		JBrowse link
G Cox6c-ps1 cytochrome c oxidase subunit VIc, pseudogene increases expression EXP Astemizole results in increased expression of COX6C-PS1 mRNA CTD PMID:20221588 NCBI chr19:52,192,612...52,193,470
Ensembl chr19:52,192,612...52,193,470 		JBrowse link
G Crh corticotropin releasing hormone multiple interactions EXP Astemizole inhibits the reaction [Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]] CTD PMID:18835572 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression EXP Astemizole results in decreased expression of CXCL3 mRNA CTD PMID:20221588 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 decreases expression EXP Astemizole results in decreased expression of CXCL9 mRNA CTD PMID:20221588 NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 multiple interactions
decreases methylation
increases metabolic processing		 ISO Arachidonic Acid inhibits the reaction [CYP2J2 protein results in decreased methylation of Astemizole]; ebastine inhibits the reaction [CYP2J2 protein results in decreased methylation of Astemizole]
CYP2J2 protein results in increased metabolism of Astemizole		 CTD PMID:12386130 PMID:15861034 PMID:17162467 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases degradation ISO CYP3A4 protein results in increased degradation of Astemizole CTD PMID:15684493 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Eaf1 ELL associated factor 1 increases expression EXP Astemizole results in increased expression of EAF1 mRNA CTD PMID:20221588 NCBI chr16:6,698,322...6,713,071
Ensembl chr16:6,698,322...6,713,071 		JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 increases expression EXP Astemizole results in increased expression of EGLN1 mRNA CTD PMID:20221588 NCBI chr19:52,867,914...52,907,169
Ensembl chr19:52,869,486...52,907,777 		JBrowse link
G Eif4a1 eukaryotic translation initiation factor 4A1 increases expression EXP Astemizole results in increased expression of EIF4A1 mRNA CTD PMID:20221588 NCBI chr10:54,384,345...54,389,853
Ensembl chr10:54,384,347...54,389,858 		JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 decreases expression EXP Astemizole results in decreased expression of ERRFI1 mRNA CTD PMID:20221588 NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282 		JBrowse link
G Etv5 ETS variant transcription factor 5 decreases expression EXP Astemizole results in decreased expression of ETV5 mRNA CTD PMID:20221588 NCBI chr11:78,608,618...78,666,221
Ensembl chr11:78,608,710...78,666,215 		JBrowse link
G Fam124a family with sequence similarity 124 member A increases expression EXP Astemizole results in increased expression of FAM124A mRNA CTD PMID:20221588 NCBI chr15:36,799,836...36,855,062
Ensembl chr15:36,799,877...36,853,683 		JBrowse link
G Fcer1a Fc epsilon receptor Ia multiple interactions EXP Astemizole inhibits the reaction [FCER1A protein results in increased secretion of HEXB protein] CTD PMID:9088877 NCBI chr13:85,686,099...85,692,394
Ensembl chr13:85,686,092...85,692,351 		JBrowse link
G Gdf10 growth differentiation factor 10 increases expression EXP Astemizole results in increased expression of GDF10 mRNA CTD PMID:20221588 NCBI chr16:9,237,182...9,250,537
Ensembl chr16:9,237,261...9,249,343 		JBrowse link
G Gimap1 GTPase, IMAP family member 1 increases expression EXP Astemizole results in increased expression of GIMAP1 mRNA CTD PMID:20221588 NCBI chr 4:77,687,581...77,691,468
Ensembl chr 4:77,682,171...77,691,866 		JBrowse link
G Gpm6b glycoprotein m6b increases expression EXP Astemizole results in increased expression of GPM6B mRNA CTD PMID:20221588 NCBI chr  X:28,057,788...28,204,409
Ensembl chr  X:28,059,450...28,204,211 		JBrowse link
G Gpx4 glutathione peroxidase 4 increases expression EXP Astemizole results in increased expression of GPX4 mRNA CTD PMID:20221588 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Hexb hexosaminidase subunit beta increases secretion
multiple interactions		 EXP Astemizole results in increased secretion of HEXB protein
Astemizole inhibits the reaction [FCER1A protein results in increased secretion of HEXB protein]		 CTD PMID:9088877 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Astemizole results in increased expression of HMOX1 mRNA CTD PMID:32661532 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions ISO [Astemizole binds to and results in decreased activity of HRH1 protein] which affects the susceptibility to Aminophylline
Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]]		 CTD PMID:12147327 PMID:16129921 NCBI chr 4:147,564,781...147,649,353
Ensembl chr 4:147,645,995...147,647,455 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 decreases expression EXP Astemizole results in decreased expression of HSP90AB1 mRNA CTD PMID:20221588 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression EXP Astemizole results in increased expression of HSPA8 mRNA CTD PMID:20221588 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Hspb8 heat shock protein family B (small) member 8 increases expression EXP Astemizole results in increased expression of HSPB8 mRNA CTD PMID:20221588 NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185 		JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 decreases expression EXP Astemizole results in decreased expression of HSPH1 mRNA CTD PMID:20221588 NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Astemizole inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein] CTD PMID:17517105 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 decreases expression EXP Astemizole results in decreased expression of IFIT3 mRNA CTD PMID:20221588 NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO Astemizole inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein] CTD PMID:17520698 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Igsf6 immunoglobulin superfamily, member 6 decreases expression EXP Astemizole results in decreased expression of IGSF6 mRNA CTD PMID:20221588 NCBI chr 1:175,610,167...175,620,662
Ensembl chr 1:175,610,167...175,620,722 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Astemizole inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; Astemizole inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] CTD PMID:17517105 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il36rn interleukin 36 receptor antagonist increases expression EXP Astemizole results in increased expression of IL36RN mRNA CTD PMID:20221588 NCBI chr 3:7,044,419...7,051,016
Ensembl chr 3:7,044,406...7,051,016 		JBrowse link
G Il7r interleukin 7 receptor decreases expression EXP Astemizole results in decreased expression of IL7R mRNA CTD PMID:20221588 NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757 		JBrowse link
G Itga8 integrin subunit alpha 8 increases expression EXP Astemizole results in increased expression of ITGA8 mRNA CTD PMID:20221588 NCBI chr17:75,304,004...75,501,510
Ensembl chr17:75,304,008...75,501,510 		JBrowse link
G Kcnh1 potassium voltage-gated channel subfamily H member 1 multiple interactions
affects binding
decreases activity		 ISO Astemizole binds to and results in decreased activity of KCNH1 protein; Astemizole inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein]
Astemizole binds to KCNH1 protein
Astemizole results in decreased activity of KCNH1 protein		 CTD PMID:14985237 PMID:16816845 PMID:17520698 PMID:18471075 PMID:18497958 More... NCBI chr13:103,722,140...104,024,762
Ensembl chr13:103,722,245...104,024,740 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
affects localization
affects binding		 ISO
EXP		 Astemizole binds to and results in decreased activity of KCNH2 protein; Astemizole inhibits the reaction [arsenic trioxide results in increased degradation of KCNH2 protein]; Astemizole inhibits the reaction [Digoxin results in decreased activity of KCNH2 protein]; Astemizole inhibits the reaction [Digoxin results in decreased metabolism of KCNH2 protein modified form]; Astemizole inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; dofetilide analog inhibits the reaction [Astemizole binds to KCNH2 protein]; Hydrogen Peroxide inhibits the reaction [Astemizole results in decreased activity of KCNH2 protein mutant form]; Potassium promotes the reaction [Astemizole binds to KCNH2 protein]
Astemizole affects the localization of KCNH2 protein mutant form
Astemizole binds to KCNH2 gene polymorphism; Astemizole binds to KCNH2 protein		 CTD PMID:8641472 PMID:9658196 PMID:10376921 PMID:10422790 PMID:10531299 More... NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Kcnq2 potassium voltage-gated channel subfamily Q member 2 multiple interactions ISO Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]] CTD PMID:12147327 NCBI chr 3:168,194,776...168,253,831
Ensembl chr 3:168,195,357...168,275,071 		JBrowse link
G Kcnq3 potassium voltage-gated channel subfamily Q member 3 multiple interactions ISO Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]] CTD PMID:12147327 NCBI chr 7:97,730,219...98,025,652
Ensembl chr 7:97,730,465...98,025,653 		JBrowse link
G Maoa monoamine oxidase A decreases expression EXP Astemizole results in decreased expression of MAOA mRNA CTD PMID:20221588 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Mapt microtubule-associated protein tau affects binding ISO Astemizole binds to MAPT protein alternative form CTD PMID:20110603 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression EXP Astemizole results in decreased expression of MMP2 mRNA CTD PMID:20221588 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Ms4a6a membrane spanning 4-domains A6A decreases expression EXP Astemizole results in decreased expression of MS4A6A mRNA CTD PMID:20221588 NCBI chr 1:208,401,465...208,414,831
Ensembl chr 1:208,401,466...208,414,758 		JBrowse link
G Mt2A metallothionein 2A increases expression ISO Astemizole results in increased expression of MT2A mRNA CTD PMID:32661532 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Mtf1 metal-regulatory transcription factor 1 multiple interactions ISO MTF1 protein affects the reaction [Astemizole results in increased expression of MT1M mRNA] CTD PMID:32661532 NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136 		JBrowse link
G Mtus1 microtubule associated scaffold protein 1 decreases expression EXP Astemizole results in decreased expression of MTUS1 mRNA CTD PMID:20221588 NCBI chr16:51,202,497...51,347,791
Ensembl chr16:51,253,562...51,347,793 		JBrowse link
G Myh6 myosin heavy chain 6 increases expression EXP Astemizole results in increased expression of MYH6 mRNA CTD PMID:20221588 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720 		JBrowse link
G Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 increases expression EXP Astemizole results in increased expression of NDUFS7 mRNA CTD PMID:20221588 NCBI chr 7:9,452,556...9,460,135
Ensembl chr 7:9,450,392...9,460,195 		JBrowse link
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 increases expression EXP Astemizole results in increased expression of NDUFV2 mRNA CTD PMID:20221588 NCBI chr 9:105,690,454...105,710,669
Ensembl chr 9:105,690,455...105,710,713 		JBrowse link
G Necab1 N-terminal EF-hand calcium binding protein 1 decreases expression EXP Astemizole results in decreased expression of NECAB1 mRNA CTD PMID:20221588 NCBI chr 5:28,357,859...28,578,642
Ensembl chr 5:28,357,859...28,578,642 		JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 increases expression EXP Astemizole results in increased expression of NR4A3 mRNA CTD PMID:20221588 NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733 		JBrowse link
G Oasl 2'-5'-oligoadenylate synthetase-like decreases expression EXP Astemizole results in decreased expression of OASL1 mRNA CTD PMID:20221588 NCBI chr12:41,682,900...41,695,641
Ensembl chr12:41,682,900...41,695,641 		JBrowse link
G Osbpl3 oxysterol binding protein-like 3 increases expression EXP Astemizole results in increased expression of OSBPL3 mRNA CTD PMID:20221588 NCBI chr 4:79,346,583...79,523,523
Ensembl chr 4:79,350,349...79,523,393 		JBrowse link
G Osgepl1 O-sialoglycoprotein endopeptidase-like 1 increases expression EXP Astemizole results in increased expression of OSGEPL1 mRNA CTD PMID:20221588 NCBI chr 9:48,214,995...48,229,440
Ensembl chr 9:48,215,402...48,229,388 		JBrowse link
G Park7 Parkinsonism associated deglycase increases expression EXP Astemizole results in increased expression of PARK7 mRNA CTD PMID:20221588 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
G Pcdh17 protocadherin 17 decreases expression EXP Astemizole results in decreased expression of PCDH17 mRNA CTD PMID:20221588 NCBI chr15:60,222,088...60,316,172
Ensembl chr15:60,222,004...60,313,999 		JBrowse link
G Peli2 pellino E3 ubiquitin protein ligase family member 2 increases expression EXP Astemizole results in increased expression of PELI2 mRNA CTD PMID:20221588 NCBI chr15:21,393,262...21,537,737
Ensembl chr15:21,393,262...21,535,106 		JBrowse link
G Prl8a3 prolactin family 8, subfamily A, member 3 decreases expression EXP Astemizole results in decreased expression of PRL8A3 mRNA CTD PMID:20221588 NCBI chr17:37,508,328...37,514,832
Ensembl chr17:37,508,328...37,514,825 		JBrowse link
G Psmb5 proteasome 20S subunit beta 5 increases expression EXP Astemizole results in increased expression of PSMB5 mRNA CTD PMID:20221588 NCBI chr15:28,072,772...28,077,367
Ensembl chr15:28,072,781...28,077,440 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression EXP Astemizole results in decreased expression of PTGS1 mRNA CTD PMID:20221588 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Pycr3 pyrroline-5-carboxylate reductase 3 increases expression EXP Astemizole results in increased expression of PYCR3 mRNA CTD PMID:20221588 NCBI chr 7:107,603,543...107,608,831
Ensembl chr 7:107,581,930...107,608,799 		JBrowse link
G Pygm glycogen phosphorylase, muscle associated increases expression EXP Astemizole results in increased expression of PYGM mRNA CTD PMID:20221588 NCBI chr 1:203,690,550...203,705,369
Ensembl chr 1:203,690,533...203,705,368 		JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression EXP Astemizole results in increased expression of S100A8 mRNA CTD PMID:20221588 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643 		JBrowse link
G S100b S100 calcium binding protein B decreases expression EXP Astemizole results in decreased expression of S100B mRNA CTD PMID:20221588 NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743 		JBrowse link
G Sik1 salt-inducible kinase 1 decreases expression EXP Astemizole results in decreased expression of SIK1 mRNA CTD PMID:20221588 NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991 		JBrowse link
G Slc1a1 solute carrier family 1 member 1 increases expression EXP Astemizole results in increased expression of SLC1A1 mRNA CTD PMID:20221588 NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression EXP Astemizole results in increased expression of SOD2 mRNA CTD PMID:20221588 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sqstm1 sequestosome 1 increases expression EXP Astemizole results in increased expression of SQSTM1 mRNA CTD PMID:20221588 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Tf transferrin decreases expression EXP Astemizole results in decreased expression of TF mRNA CTD PMID:20221588 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression EXP Astemizole results in increased expression of TGFB2 mRNA CTD PMID:20221588 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Tlr2 toll-like receptor 2 decreases expression EXP Astemizole results in decreased expression of TLR2 mRNA CTD PMID:20221588 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr7 toll-like receptor 7 decreases expression EXP Astemizole results in decreased expression of TLR7 mRNA CTD PMID:20221588 NCBI chr  X:27,027,380...27,054,309
Ensembl chr  X:27,027,425...27,054,754 		JBrowse link
G Tmod1 tropomodulin 1 increases expression EXP Astemizole results in increased expression of TMOD1 mRNA CTD PMID:20221588 NCBI chr 5:60,316,445...60,393,957
Ensembl chr 5:60,338,512...60,393,956 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Astemizole inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] CTD PMID:17517105 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vcan versican decreases expression EXP Astemizole results in decreased expression of VCAN mRNA CTD PMID:20221588 NCBI chr 2:20,761,718...20,860,637
Ensembl chr 2:20,761,718...20,860,637 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19740
    role 19713
      biological role 19711
        antimicrobial agent 17880
          antiviral agent 10711
            anticoronaviral agent 9332
              astemizole 89
Path 2
Term Annotations click to browse term
  CHEBI ontology 19740
    subatomic particle 19738
      composite particle 19738
        hadron 19738
          baryon 19738
            nucleon 19738
              atomic nucleus 19738
                atom 19738
                  main group element atom 19686
                    p-block element atom 19686
                      carbon group element atom 19631
                        carbon atom 19627
                          organic molecular entity 19627
                            organic molecule 19587
                              organic cyclic compound 19393
                                organic heterocyclic compound 18766
                                  organic heteropolycyclic compound 18254
                                    organic heterobicyclic compound 17226
                                      benzimidazoles 1155
                                        astemizole 89
paths to the root