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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:astemizole
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Accession:CHEBI:2896 term browser browse the term
Definition:A piperidine compound having a 2-(4-methoxyphenyl)ethyl group at the 1-position and an N-[(4-fluorobenzyl)benzimidazol-2-yl]amino group at the 4-position.
Synonyms:exact_synonym: 1-(4-fluorobenzyl)-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine
 related_synonym: 1-(p-Fluorobenzyl)-2-((1-(2-(p-methoxyphenyl)ethyl)piperid-4-yl)amino)benzimidazole;   1-(p-Fluorobenzyl)-2-((1-(p-methoxyphenethyl)-4-piperidyl)amino)benzimidazole;   Astemison;   Formula=C28H31FN4O;   InChI=1S/C28H31FN4O/c1-34-25-12-8-21(9-13-25)14-17-32-18-15-24(16-19-32)30-28-31-26-4-2-3-5-27(26)33(28)20-22-6-10-23(29)11-7-22/h2-13,24H,14-20H2,1H3,(H,30,31);   InChIKey=GXDALQBWZGODGZ-UHFFFAOYSA-N;   SMILES=COc1ccc(CCN2CCC(CC2)Nc2nc3ccccc3n2Cc2ccc(F)cc2)cc1;   astemizol;   astemizolum
 xref: Beilstein:4830190;   CAS:68844-77-9;   DrugBank:DB00637;   Drug_Central:249;   KEGG:C06832;   KEGG:D00234;   LINCS:LSM-5502
 xref_mesh: MESH:D016589
 xref: Patent:EP5318;   Patent:US4219559


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astemizole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Astemizole inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Astemizole results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Ak3 adenylate kinase 3 increases expression EXP Astemizole results in increased expression of AK3 mRNA CTD PMID:20221588 NCBI chr 1:247,144,486...247,169,690
Ensembl chr 1:247,144,491...247,169,693
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 increases expression EXP Astemizole results in increased expression of ALAS2 mRNA CTD PMID:20221588 NCBI chr  X:23,167,576...23,187,356
Ensembl chr  X:23,167,696...23,187,341
JBrowse link
G Angpt2 angiopoietin 2 increases expression EXP Astemizole results in increased expression of ANGPT2 mRNA CTD PMID:20221588 NCBI chr16:75,966,480...76,016,147
Ensembl chr16:75,966,352...76,016,195
JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 increases expression EXP Astemizole results in increased expression of ATP1B1 mRNA CTD PMID:20221588 NCBI chr13:82,737,161...82,757,681
Ensembl chr13:82,737,159...82,758,004
JBrowse link
G Atp1b2 ATPase Na+/K+ transporting subunit beta 2 decreases expression EXP Astemizole results in decreased expression of ATP1B2 mRNA CTD PMID:20221588 NCBI chr10:56,205,622...56,211,879
Ensembl chr10:56,205,625...56,211,891
JBrowse link
G Atp5f1e ATP synthase F1 subunit epsilon increases expression EXP Astemizole results in increased expression of ATP5F1E mRNA CTD PMID:20221588 NCBI chr 3:172,563,105...172,566,007
Ensembl chr 3:172,563,105...172,566,010
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression EXP Astemizole results in decreased expression of BCL2 mRNA CTD PMID:20221588 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bmp1 bone morphogenetic protein 1 decreases expression EXP Astemizole results in decreased expression of BMP1 mRNA CTD PMID:20221588 NCBI chr15:52,166,401...52,210,786
Ensembl chr15:52,166,401...52,210,746
JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II delta decreases expression EXP Astemizole results in decreased expression of CAMK2D mRNA CTD PMID:20221588 NCBI chr 2:230,900,907...231,132,207
Ensembl chr 2:230,901,126...231,132,039
JBrowse link
G Cat catalase increases expression EXP Astemizole results in increased expression of CAT mRNA CTD PMID:20221588 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 decreases expression EXP Astemizole results in decreased expression of CCL7 mRNA CTD PMID:20221588 NCBI chr10:69,423,083...69,424,933
Ensembl chr10:69,423,086...69,424,979
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression EXP Astemizole results in increased expression of CEBPB mRNA CTD PMID:20221588 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Cebpg CCAAT/enhancer binding protein gamma decreases expression EXP Astemizole results in decreased expression of CEBPG mRNA CTD PMID:20221588 NCBI chr 1:91,286,956...91,297,459
Ensembl chr 1:91,287,917...91,296,656
JBrowse link
G Cfh complement factor H decreases expression EXP Astemizole results in decreased expression of CFH mRNA CTD PMID:20221588 NCBI chr13:56,979,155...57,080,540
Ensembl chr13:56,978,607...57,080,622
JBrowse link
G Colec12 collectin sub-family member 12 decreases expression EXP Astemizole results in decreased expression of COLEC12 mRNA CTD PMID:20221588 NCBI chr18:867,048...1,054,047
Ensembl chr18:867,048...1,052,606
JBrowse link
G Cox6c-ps1 cytochrome c oxidase subunit VIc, pseudogene increases expression EXP Astemizole results in increased expression of COX6C-PS1 mRNA CTD PMID:20221588 NCBI chr19:56,982,949...56,983,807
Ensembl chr19:56,982,949...56,983,807
JBrowse link
G Crh corticotropin releasing hormone multiple interactions EXP Astemizole inhibits the reaction [Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]] CTD PMID:18835572 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression EXP Astemizole results in decreased expression of CXCL3 mRNA CTD PMID:20221588 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 decreases expression EXP Astemizole results in decreased expression of CXCL9 mRNA CTD PMID:20221588 NCBI chr14:17,228,832...17,233,743
Ensembl chr14:17,228,856...17,234,712
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 multiple interactions
increases metabolic processing
decreases methylation
ISO Arachidonic Acid inhibits the reaction [CYP2J2 protein results in decreased methylation of Astemizole]; ebastine inhibits the reaction [CYP2J2 protein results in decreased methylation of Astemizole]
CYP2J2 protein results in increased metabolism of Astemizole
CTD PMID:12386130 PMID:15861034 PMID:17162467 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases degradation ISO CYP3A4 protein results in increased degradation of Astemizole CTD PMID:15684493 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Eaf1 ELL associated factor 1 increases expression EXP Astemizole results in increased expression of EAF1 mRNA CTD PMID:20221588 NCBI chr16:7,588,217...7,602,966
Ensembl chr16:7,588,217...7,602,966
JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 increases expression EXP Astemizole results in increased expression of EGLN1 mRNA CTD PMID:20221588 NCBI chr19:57,660,194...57,701,158
Ensembl chr19:57,662,278...57,699,113
JBrowse link
G Eif4a1 eukaryotic translation initiation factor 4A1 increases expression EXP Astemizole results in increased expression of EIF4A1 mRNA CTD PMID:20221588 NCBI chr10:56,271,257...56,276,764
Ensembl chr10:56,271,257...56,276,764
JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 decreases expression EXP Astemizole results in decreased expression of ERRFI1 mRNA CTD PMID:20221588 NCBI chr 5:167,951,564...167,966,011
Ensembl chr 5:167,952,728...167,966,009
JBrowse link
G Etv5 ETS variant transcription factor 5 decreases expression EXP Astemizole results in decreased expression of ETV5 mRNA CTD PMID:20221588 NCBI chr11:82,194,657...82,252,145
Ensembl chr11:82,194,657...82,252,139
JBrowse link
G Fam124a family with sequence similarity 124 member A increases expression EXP Astemizole results in increased expression of FAM124A mRNA CTD PMID:20221588 NCBI chr15:45,711,994...45,780,395
Ensembl chr15:45,712,821...45,780,405
JBrowse link
G Fcer1a Fc fragment of IgE receptor Ia multiple interactions EXP Astemizole inhibits the reaction [FCER1A protein results in increased secretion of HEXB protein] CTD PMID:9088877 NCBI chr13:91,727,253...91,737,106
Ensembl chr13:91,730,925...91,737,053
JBrowse link
G Gdf10 growth differentiation factor 10 increases expression EXP Astemizole results in increased expression of GDF10 mRNA CTD PMID:20221588 NCBI chr16:10,250,508...10,262,383
Ensembl chr16:10,250,404...10,263,150
JBrowse link
G Gimap1 GTPase, IMAP family member 1 increases expression EXP Astemizole results in increased expression of GIMAP1 mRNA CTD PMID:20221588 NCBI chr 4:78,365,276...78,375,450
Ensembl chr 4:78,371,121...78,375,223
JBrowse link
G Gpm6b glycoprotein m6b increases expression EXP Astemizole results in increased expression of GPM6B mRNA CTD PMID:20221588 NCBI chr  X:29,604,607...29,751,174
Ensembl chr  X:29,607,075...29,648,403
JBrowse link
G Gpx4 glutathione peroxidase 4 increases expression EXP Astemizole results in increased expression of GPX4 mRNA CTD PMID:20221588 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
JBrowse link
G Hexb hexosaminidase subunit beta increases secretion
multiple interactions
EXP Astemizole results in increased secretion of HEXB protein
Astemizole inhibits the reaction [FCER1A protein results in increased secretion of HEXB protein]
CTD PMID:9088877 NCBI chr 2:27,983,925...28,003,260
Ensembl chr 2:27,984,117...28,003,186
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions ISO [Astemizole binds to and results in decreased activity of HRH1 protein] which affects the susceptibility to Aminophylline
Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]]
CTD PMID:12147327 PMID:16129921 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 decreases expression EXP Astemizole results in decreased expression of HSP90AB1 mRNA CTD PMID:20221588 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression EXP Astemizole results in increased expression of HSPA8 mRNA CTD PMID:20221588 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Hspb8 heat shock protein family B (small) member 8 increases expression EXP Astemizole results in increased expression of HSPB8 mRNA CTD PMID:20221588 NCBI chr12:45,905,371...45,920,014
Ensembl chr12:45,905,371...45,920,013
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 decreases expression EXP Astemizole results in decreased expression of HSPH1 mRNA CTD PMID:20221588 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Astemizole inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein] CTD PMID:17517105 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 decreases expression EXP Astemizole results in decreased expression of IFIT3 mRNA CTD PMID:20221588 NCBI chr 1:252,906,234...252,911,377
Ensembl chr 1:252,906,234...252,911,382
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO Astemizole inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein] CTD PMID:17520698 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igsf6 immunoglobulin superfamily, member 6 decreases expression EXP Astemizole results in decreased expression of IGSF6 mRNA CTD PMID:20221588 NCBI chr 1:190,997,029...191,007,503
Ensembl chr 1:190,997,029...191,007,503
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Astemizole inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; Astemizole inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] CTD PMID:17517105 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il7r interleukin 7 receptor decreases expression EXP Astemizole results in decreased expression of IL7R mRNA CTD PMID:20221588
G Itga8 integrin subunit alpha 8 increases expression EXP Astemizole results in increased expression of ITGA8 mRNA CTD PMID:20221588 NCBI chr17:79,321,893...79,676,927
Ensembl chr17:79,321,900...79,676,499
JBrowse link
G Kcnh1 potassium voltage-gated channel subfamily H member 1 multiple interactions
decreases activity
affects binding
ISO Astemizole binds to and results in decreased activity of KCNH1 protein; Astemizole inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein]
Astemizole results in decreased activity of KCNH1 protein
Astemizole binds to KCNH1 protein
CTD PMID:14985237 PMID:16816845 PMID:17520698 PMID:18471075 PMID:18497958 PMID:20050851 NCBI chr13:110,920,712...111,232,291
Ensembl chr13:110,920,737...111,232,269
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
affects binding
decreases activity
affects localization
ISO
EXP
Astemizole binds to and results in decreased activity of KCNH2 protein; Astemizole inhibits the reaction [arsenic trioxide results in increased degradation of KCNH2 protein]; Astemizole inhibits the reaction [Digoxin results in decreased activity of KCNH2 protein]; Astemizole inhibits the reaction [Digoxin results in decreased metabolism of KCNH2 protein modified form]; Astemizole inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; dofetilide analog inhibits the reaction [Astemizole binds to KCNH2 protein]; Hydrogen Peroxide inhibits the reaction [Astemizole results in decreased activity of KCNH2 protein mutant form]; Potassium promotes the reaction [Astemizole binds to KCNH2 protein]
Astemizole binds to KCNH2 gene polymorphism; Astemizole binds to KCNH2 protein
Astemizole affects the localization of KCNH2 protein mutant form
CTD PMID:8641472 PMID:9658196 PMID:10376921 PMID:10422790 PMID:10531299 PMID:10828461 PMID:11040061 PMID:11082114 PMID:11705456 PMID:11741928 PMID:12388285 PMID:15272206 PMID:15671647 PMID:15740727 PMID:16723379 PMID:18701618 PMID:19139152 PMID:19583963 PMID:21158687 PMID:24052561 PMID:24200993 PMID:28521025 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kcnq2 potassium voltage-gated channel subfamily Q member 2 multiple interactions ISO Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]] CTD PMID:12147327 NCBI chr 3:176,585,897...176,645,029
Ensembl chr 3:176,589,906...176,644,951
JBrowse link
G Kcnq3 potassium voltage-gated channel subfamily Q member 3 multiple interactions ISO Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]] CTD PMID:12147327 NCBI chr 7:106,714,479...107,009,639
Ensembl chr 7:106,717,229...107,009,330
JBrowse link
G Maoa monoamine oxidase A decreases expression EXP Astemizole results in decreased expression of MAOA mRNA CTD PMID:20221588 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
JBrowse link
G Mapt microtubule-associated protein tau affects binding ISO Astemizole binds to MAPT protein alternative form CTD PMID:20110603 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression EXP Astemizole results in decreased expression of MMP2 mRNA CTD PMID:20221588 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Ms4a6a membrane spanning 4-domains A6A decreases expression EXP Astemizole results in decreased expression of MS4A6A mRNA CTD PMID:20221588 NCBI chr 1:227,919,284...227,932,637
Ensembl chr 1:227,919,301...227,932,603
JBrowse link
G Mtus1 microtubule associated scaffold protein 1 decreases expression EXP Astemizole results in decreased expression of MTUS1 mRNA CTD PMID:20221588 NCBI chr16:54,240,892...54,386,131
Ensembl chr16:54,291,251...54,386,129
JBrowse link
G Myh6 myosin heavy chain 6 increases expression EXP Astemizole results in increased expression of MYH6 mRNA CTD PMID:20221588 NCBI chr15:33,605,653...33,629,730
Ensembl chr15:33,605,654...33,629,699
JBrowse link
G Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 increases expression EXP Astemizole results in increased expression of NDUFS7 mRNA CTD PMID:20221588 NCBI chr 7:12,318,776...12,326,403
Ensembl chr 7:12,318,757...12,326,392
JBrowse link
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 increases expression EXP Astemizole results in increased expression of NDUFV2 mRNA CTD PMID:20221588 NCBI chr 9:113,875,718...113,900,169
Ensembl chr 9:113,875,703...113,900,190
JBrowse link
G Necab1 N-terminal EF-hand calcium binding protein 1 decreases expression EXP Astemizole results in decreased expression of NECAB1 mRNA CTD PMID:20221588 NCBI chr 5:28,507,596...28,737,556
Ensembl chr 5:28,504,558...28,737,719
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 increases expression EXP Astemizole results in increased expression of NR4A3 mRNA CTD PMID:20221588 NCBI chr 5:63,781,801...63,822,890
Ensembl chr 5:63,781,801...63,821,637
JBrowse link
G Oasl 2'-5'-oligoadenylate synthetase-like decreases expression EXP Astemizole results in decreased expression of OASL1 mRNA CTD PMID:20221588 NCBI chr12:47,444,138...47,456,680
Ensembl chr12:47,444,104...47,456,894
JBrowse link
G Osbpl3 oxysterol binding protein-like 3 increases expression EXP Astemizole results in increased expression of OSBPL3 mRNA CTD PMID:20221588 NCBI chr 4:80,025,453...80,202,532
Ensembl chr 4:80,025,440...80,107,884
JBrowse link
G Osgepl1 O-sialoglycoprotein endopeptidase-like 1 increases expression EXP Astemizole results in increased expression of OSGEPL1 mRNA CTD PMID:20221588 NCBI chr 9:53,084,042...53,098,029
Ensembl chr 9:53,084,045...53,097,979
JBrowse link
G Park7 Parkinsonism associated deglycase increases expression EXP Astemizole results in increased expression of PARK7 mRNA CTD PMID:20221588 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link
G Pcdh17 protocadherin 17 decreases expression EXP Astemizole results in decreased expression of PCDH17 mRNA CTD PMID:20221588 NCBI chr15:67,555,835...67,647,990
Ensembl chr15:67,555,835...67,645,088
JBrowse link
G Peli2 pellino E3 ubiquitin protein ligase family member 2 increases expression EXP Astemizole results in increased expression of PELI2 mRNA CTD PMID:20221588 NCBI chr15:24,942,218...25,086,350
Ensembl chr15:24,942,218...25,083,931
JBrowse link
G Prl8a3 prolactin family 8, subfamily a, member 3 decreases expression EXP Astemizole results in decreased expression of PRL8A3 mRNA CTD PMID:20221588 NCBI chr17:39,455,865...39,463,715
Ensembl chr17:39,455,908...39,462,629
JBrowse link
G Psmb5 proteasome 20S subunit beta 5 increases expression EXP Astemizole results in increased expression of PSMB5 mRNA CTD PMID:20221588 NCBI chr15:33,259,039...33,263,634
Ensembl chr15:33,259,043...33,263,659
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression EXP Astemizole results in decreased expression of PTGS1 mRNA CTD PMID:20221588 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Pycr3 pyrroline-5-carboxylate reductase 3 increases expression EXP Astemizole results in increased expression of PYCR3 mRNA CTD PMID:20221588 NCBI chr 7:116,949,882...116,955,150
Ensembl chr 7:116,949,879...116,955,148
JBrowse link
G Pygm glycogen phosphorylase, muscle associated increases expression EXP Astemizole results in increased expression of PYGM mRNA CTD PMID:20221588 NCBI chr 1:221,756,325...221,771,142
Ensembl chr 1:221,756,286...221,771,143
JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression EXP Astemizole results in increased expression of S100A8 mRNA CTD PMID:20221588 NCBI chr 2:190,073,239...190,074,333
Ensembl chr 2:190,073,815...190,074,354
JBrowse link
G S100b S100 calcium binding protein B decreases expression EXP Astemizole results in decreased expression of S100B mRNA CTD PMID:20221588 NCBI chr20:13,130,633...13,142,856
Ensembl chr20:13,130,636...13,142,856
JBrowse link
G Sik1 salt-inducible kinase 1 decreases expression EXP Astemizole results in decreased expression of SIK1 mRNA CTD PMID:20221588 NCBI chr20:10,670,747...10,680,279
Ensembl chr20:10,668,411...10,680,283
JBrowse link
G Slc1a1 solute carrier family 1 member 1 increases expression EXP Astemizole results in increased expression of SLC1A1 mRNA CTD PMID:20221588 NCBI chr 1:246,955,017...247,035,159
Ensembl chr 1:246,954,980...247,037,056
JBrowse link
G Sod2 superoxide dismutase 2 increases expression EXP Astemizole results in increased expression of SOD2 mRNA CTD PMID:20221588 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sqstm1 sequestosome 1 increases expression EXP Astemizole results in increased expression of SQSTM1 mRNA CTD PMID:20221588 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Tf transferrin decreases expression EXP Astemizole results in decreased expression of TF mRNA CTD PMID:20221588 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression EXP Astemizole results in increased expression of TGFB2 mRNA CTD PMID:20221588 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tlr2 toll-like receptor 2 decreases expression EXP Astemizole results in decreased expression of TLR2 mRNA CTD PMID:20221588 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tlr7 toll-like receptor 7 decreases expression EXP Astemizole results in decreased expression of TLR7 mRNA CTD PMID:20221588 NCBI chr  X:28,486,836...28,513,004
Ensembl chr  X:28,486,869...28,512,957
JBrowse link
G Tmod1 tropomodulin 1 increases expression EXP Astemizole results in increased expression of TMOD1 mRNA CTD PMID:20221588 NCBI chr 5:61,635,244...61,712,052
Ensembl chr 5:61,657,507...61,712,051
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Astemizole inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] CTD PMID:17517105 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vcan versican decreases expression EXP Astemizole results in decreased expression of VCAN mRNA CTD PMID:20221588 NCBI chr 2:18,490,102...18,587,340
Ensembl chr 2:18,490,102...18,565,842
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    role 19804
      biological role 19804
        antimicrobial agent 17392
          antiviral agent 10262
            anticoronaviral agent 8950
              astemizole 84
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19744
                    p-block element atom 19744
                      carbon group element atom 19650
                        carbon atom 19639
                          organic molecular entity 19639
                            organic molecule 19568
                              organic cyclic compound 19378
                                organic heterocyclic compound 18495
                                  organic heteropolycyclic compound 17883
                                    organic heterobicyclic compound 16814
                                      benzimidazoles 857
                                        astemizole 84
paths to the root