CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: astemizole
Accession: CHEBI:2896
browse the term
Definition: A piperidine compound having a 2-(4-methoxyphenyl)ethyl group at the 1-position and an N-[(4-fluorobenzyl)benzimidazol-2-yl]amino group at the 4-position.
Synonyms: exact_synonym: 1-(4-fluorobenzyl)-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine
related_synonym: 1-(p-Fluorobenzyl)-2-((1-(2-(p-methoxyphenyl)ethyl)piperid-4-yl)amino)benzimidazole; 1-(p-Fluorobenzyl)-2-((1-(p-methoxyphenethyl)-4-piperidyl)amino)benzimidazole; Astemison; Formula=C28H31FN4O; InChI=1S/C28H31FN4O/c1-34-25-12-8-21(9-13-25)14-17-32-18-15-24(16-19-32)30-28-31-26-4-2-3-5-27(26)33(28)20-22-6-10-23(29)11-7-22/h2-13,24H,14-20H2,1H3,(H,30,31); InChIKey=GXDALQBWZGODGZ-UHFFFAOYSA-N; SMILES=COc1ccc(CCN2CCC(CC2)Nc2nc3ccccc3n2Cc2ccc(F)cc2)cc1; astemizol; astemizolum
xref: Beilstein:4830190; CAS:68844-77-9; DrugBank:DB00637; Drug_Central:249; KEGG:C06832; KEGG:D00234; LINCS:LSM-5502
xref_mesh: MESH:D016589
xref: Patent:EP5318; Patent:US4219559
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Abcb11
ATP binding cassette subfamily B member 11
multiple interactions decreases activity
ISO
Astemizole inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] Astemizole results in decreased activity of ABCB11 protein
CTD
PMID:24014644
NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
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Ak3
adenylate kinase 3
increases expression
EXP
Astemizole results in increased expression of AK3 mRNA
CTD
PMID:20221588
NCBI chr 1:247,144,486...247,169,690
Ensembl chr 1:247,144,491...247,169,693
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Alas2
5'-aminolevulinate synthase 2
increases expression
EXP
Astemizole results in increased expression of ALAS2 mRNA
CTD
PMID:20221588
NCBI chr X:23,167,576...23,187,356
Ensembl chr X:23,167,696...23,187,341
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Angpt2
angiopoietin 2
increases expression
EXP
Astemizole results in increased expression of ANGPT2 mRNA
CTD
PMID:20221588
NCBI chr16:75,966,480...76,016,147
Ensembl chr16:75,966,352...76,016,195
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Atp1b1
ATPase Na+/K+ transporting subunit beta 1
increases expression
EXP
Astemizole results in increased expression of ATP1B1 mRNA
CTD
PMID:20221588
NCBI chr13:82,737,161...82,757,681
Ensembl chr13:82,737,159...82,758,004
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Atp1b2
ATPase Na+/K+ transporting subunit beta 2
decreases expression
EXP
Astemizole results in decreased expression of ATP1B2 mRNA
CTD
PMID:20221588
NCBI chr10:56,205,622...56,211,879
Ensembl chr10:56,205,625...56,211,891
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Atp5f1e
ATP synthase F1 subunit epsilon
increases expression
EXP
Astemizole results in increased expression of ATP5F1E mRNA
CTD
PMID:20221588
NCBI chr 3:172,563,105...172,566,007
Ensembl chr 3:172,563,105...172,566,010
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Bcl2
BCL2, apoptosis regulator
decreases expression
EXP
Astemizole results in decreased expression of BCL2 mRNA
CTD
PMID:20221588
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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Bmp1
bone morphogenetic protein 1
decreases expression
EXP
Astemizole results in decreased expression of BMP1 mRNA
CTD
PMID:20221588
NCBI chr15:52,166,401...52,210,786
Ensembl chr15:52,166,401...52,210,746
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Camk2d
calcium/calmodulin-dependent protein kinase II delta
decreases expression
EXP
Astemizole results in decreased expression of CAMK2D mRNA
CTD
PMID:20221588
NCBI chr 2:230,900,907...231,132,207
Ensembl chr 2:230,901,126...231,132,039
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Cat
catalase
increases expression
EXP
Astemizole results in increased expression of CAT mRNA
CTD
PMID:20221588
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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Ccl7
C-C motif chemokine ligand 7
decreases expression
EXP
Astemizole results in decreased expression of CCL7 mRNA
CTD
PMID:20221588
NCBI chr10:69,423,083...69,424,933
Ensembl chr10:69,423,086...69,424,979
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Cebpb
CCAAT/enhancer binding protein beta
increases expression
EXP
Astemizole results in increased expression of CEBPB mRNA
CTD
PMID:20221588
NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
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Cebpg
CCAAT/enhancer binding protein gamma
decreases expression
EXP
Astemizole results in decreased expression of CEBPG mRNA
CTD
PMID:20221588
NCBI chr 1:91,286,956...91,297,459
Ensembl chr 1:91,287,917...91,296,656
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Cfh
complement factor H
decreases expression
EXP
Astemizole results in decreased expression of CFH mRNA
CTD
PMID:20221588
NCBI chr13:56,979,155...57,080,540
Ensembl chr13:56,978,607...57,080,622
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Colec12
collectin sub-family member 12
decreases expression
EXP
Astemizole results in decreased expression of COLEC12 mRNA
CTD
PMID:20221588
NCBI chr18:867,048...1,054,047
Ensembl chr18:867,048...1,052,606
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Cox6c-ps1
cytochrome c oxidase subunit VIc, pseudogene
increases expression
EXP
Astemizole results in increased expression of COX6C-PS1 mRNA
CTD
PMID:20221588
NCBI chr19:56,982,949...56,983,807
Ensembl chr19:56,982,949...56,983,807
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Crh
corticotropin releasing hormone
multiple interactions
EXP
Astemizole inhibits the reaction [Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]]
CTD
PMID:18835572
NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
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Cxcl3
C-X-C motif chemokine ligand 3
decreases expression
EXP
Astemizole results in decreased expression of CXCL3 mRNA
CTD
PMID:20221588
NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
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Cxcl9
C-X-C motif chemokine ligand 9
decreases expression
EXP
Astemizole results in decreased expression of CXCL9 mRNA
CTD
PMID:20221588
NCBI chr14:17,228,832...17,233,743
Ensembl chr14:17,228,856...17,234,712
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Cyp2j4
cytochrome P450, family 2, subfamily j, polypeptide 4
multiple interactions increases metabolic processing decreases methylation
ISO
Arachidonic Acid inhibits the reaction [CYP2J2 protein results in decreased methylation of Astemizole]; ebastine inhibits the reaction [CYP2J2 protein results in decreased methylation of Astemizole] CYP2J2 protein results in increased metabolism of Astemizole
CTD
PMID:12386130 PMID:15861034 PMID:17162467
NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846
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Cyp3a62
cytochrome P450, family 3, subfamily a, polypeptide 62
increases degradation
ISO
CYP3A4 protein results in increased degradation of Astemizole
CTD
PMID:15684493
NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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Eaf1
ELL associated factor 1
increases expression
EXP
Astemizole results in increased expression of EAF1 mRNA
CTD
PMID:20221588
NCBI chr16:7,588,217...7,602,966
Ensembl chr16:7,588,217...7,602,966
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Egln1
egl-9 family hypoxia-inducible factor 1
increases expression
EXP
Astemizole results in increased expression of EGLN1 mRNA
CTD
PMID:20221588
NCBI chr19:57,660,194...57,701,158
Ensembl chr19:57,662,278...57,699,113
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Eif4a1
eukaryotic translation initiation factor 4A1
increases expression
EXP
Astemizole results in increased expression of EIF4A1 mRNA
CTD
PMID:20221588
NCBI chr10:56,271,257...56,276,764
Ensembl chr10:56,271,257...56,276,764
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Errfi1
ERBB receptor feedback inhibitor 1
decreases expression
EXP
Astemizole results in decreased expression of ERRFI1 mRNA
CTD
PMID:20221588
NCBI chr 5:167,951,564...167,966,011
Ensembl chr 5:167,952,728...167,966,009
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Etv5
ETS variant transcription factor 5
decreases expression
EXP
Astemizole results in decreased expression of ETV5 mRNA
CTD
PMID:20221588
NCBI chr11:82,194,657...82,252,145
Ensembl chr11:82,194,657...82,252,139
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Fam124a
family with sequence similarity 124 member A
increases expression
EXP
Astemizole results in increased expression of FAM124A mRNA
CTD
PMID:20221588
NCBI chr15:45,711,994...45,780,395
Ensembl chr15:45,712,821...45,780,405
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Fcer1a
Fc fragment of IgE receptor Ia
multiple interactions
EXP
Astemizole inhibits the reaction [FCER1A protein results in increased secretion of HEXB protein]
CTD
PMID:9088877
NCBI chr13:91,727,253...91,737,106
Ensembl chr13:91,730,925...91,737,053
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Gdf10
growth differentiation factor 10
increases expression
EXP
Astemizole results in increased expression of GDF10 mRNA
CTD
PMID:20221588
NCBI chr16:10,250,508...10,262,383
Ensembl chr16:10,250,404...10,263,150
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Gimap1
GTPase, IMAP family member 1
increases expression
EXP
Astemizole results in increased expression of GIMAP1 mRNA
CTD
PMID:20221588
NCBI chr 4:78,365,276...78,375,450
Ensembl chr 4:78,371,121...78,375,223
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Gpm6b
glycoprotein m6b
increases expression
EXP
Astemizole results in increased expression of GPM6B mRNA
CTD
PMID:20221588
NCBI chr X:29,604,607...29,751,174
Ensembl chr X:29,607,075...29,648,403
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Gpx4
glutathione peroxidase 4
increases expression
EXP
Astemizole results in increased expression of GPX4 mRNA
CTD
PMID:20221588
NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
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Hexb
hexosaminidase subunit beta
increases secretion multiple interactions
EXP
Astemizole results in increased secretion of HEXB protein Astemizole inhibits the reaction [FCER1A protein results in increased secretion of HEXB protein]
CTD
PMID:9088877
NCBI chr 2:27,983,925...28,003,260
Ensembl chr 2:27,984,117...28,003,186
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Hrh1
histamine receptor H 1
multiple interactions
ISO
[Astemizole binds to and results in decreased activity of HRH1 protein] which affects the susceptibility to Aminophylline Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]]
CTD
PMID:12147327 PMID:16129921
NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074
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Hsp90ab1
heat shock protein 90 alpha family class B member 1
decreases expression
EXP
Astemizole results in decreased expression of HSP90AB1 mRNA
CTD
PMID:20221588
NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
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Hspa8
heat shock protein family A (Hsp70) member 8
increases expression
EXP
Astemizole results in increased expression of HSPA8 mRNA
CTD
PMID:20221588
NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
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Hspb8
heat shock protein family B (small) member 8
increases expression
EXP
Astemizole results in increased expression of HSPB8 mRNA
CTD
PMID:20221588
NCBI chr12:45,905,371...45,920,014
Ensembl chr12:45,905,371...45,920,013
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Hsph1
heat shock protein family H (Hsp110) member 1
decreases expression
EXP
Astemizole results in decreased expression of HSPH1 mRNA
CTD
PMID:20221588
NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
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Icam1
intercellular adhesion molecule 1
multiple interactions
ISO
Astemizole inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]
CTD
PMID:17517105
NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
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Ifit3
interferon-induced protein with tetratricopeptide repeats 3
decreases expression
EXP
Astemizole results in decreased expression of IFIT3 mRNA
CTD
PMID:20221588
NCBI chr 1:252,906,234...252,911,377
Ensembl chr 1:252,906,234...252,911,382
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Igf1
insulin-like growth factor 1
multiple interactions
ISO
Astemizole inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein]
CTD
PMID:17520698
NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
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Igsf6
immunoglobulin superfamily, member 6
decreases expression
EXP
Astemizole results in decreased expression of IGSF6 mRNA
CTD
PMID:20221588
NCBI chr 1:190,997,029...191,007,503
Ensembl chr 1:190,997,029...191,007,503
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Il1b
interleukin 1 beta
multiple interactions
ISO
Astemizole inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; Astemizole inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]
CTD
PMID:17517105
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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Il7r
interleukin 7 receptor
decreases expression
EXP
Astemizole results in decreased expression of IL7R mRNA
CTD
PMID:20221588
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Itga8
integrin subunit alpha 8
increases expression
EXP
Astemizole results in increased expression of ITGA8 mRNA
CTD
PMID:20221588
NCBI chr17:79,321,893...79,676,927
Ensembl chr17:79,321,900...79,676,499
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Kcnh1
potassium voltage-gated channel subfamily H member 1
multiple interactions decreases activity affects binding
ISO
Astemizole binds to and results in decreased activity of KCNH1 protein; Astemizole inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein] Astemizole results in decreased activity of KCNH1 protein Astemizole binds to KCNH1 protein
CTD
PMID:14985237 PMID:16816845 PMID:17520698 PMID:18471075 PMID:18497958 PMID:20050851
NCBI chr13:110,920,712...111,232,291
Ensembl chr13:110,920,737...111,232,269
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Kcnh2
potassium voltage-gated channel subfamily H member 2
multiple interactions affects binding decreases activity affects localization
ISO EXP
Astemizole binds to and results in decreased activity of KCNH2 protein; Astemizole inhibits the reaction [arsenic trioxide results in increased degradation of KCNH2 protein]; Astemizole inhibits the reaction [Digoxin results in decreased activity of KCNH2 protein]; Astemizole inhibits the reaction [Digoxin results in decreased metabolism of KCNH2 protein modified form]; Astemizole inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; dofetilide analog inhibits the reaction [Astemizole binds to KCNH2 protein]; Hydrogen Peroxide inhibits the reaction [Astemizole results in decreased activity of KCNH2 protein mutant form]; Potassium promotes the reaction [Astemizole binds to KCNH2 protein] Astemizole binds to KCNH2 gene polymorphism; Astemizole binds to KCNH2 protein Astemizole affects the localization of KCNH2 protein mutant form
CTD
PMID:8641472 PMID:9658196 PMID:10376921 PMID:10422790 PMID:10531299 PMID:10828461 PMID:11040061 PMID:11082114 PMID:11705456 PMID:11741928 PMID:12388285 PMID:15272206 PMID:15671647 PMID:15740727 PMID:16723379 PMID:18701618 PMID:19139152 PMID:19583963 PMID:21158687 PMID:24052561 PMID:24200993 PMID:28521025
NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
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Kcnq2
potassium voltage-gated channel subfamily Q member 2
multiple interactions
ISO
Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]]
CTD
PMID:12147327
NCBI chr 3:176,585,897...176,645,029
Ensembl chr 3:176,589,906...176,644,951
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Kcnq3
potassium voltage-gated channel subfamily Q member 3
multiple interactions
ISO
Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]]
CTD
PMID:12147327
NCBI chr 7:106,714,479...107,009,639
Ensembl chr 7:106,717,229...107,009,330
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Maoa
monoamine oxidase A
decreases expression
EXP
Astemizole results in decreased expression of MAOA mRNA
CTD
PMID:20221588
NCBI chr X:6,554,698...6,620,722
Ensembl chr X:6,554,698...6,620,722
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Mapt
microtubule-associated protein tau
affects binding
ISO
Astemizole binds to MAPT protein alternative form
CTD
PMID:20110603
NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
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Mmp2
matrix metallopeptidase 2
decreases expression
EXP
Astemizole results in decreased expression of MMP2 mRNA
CTD
PMID:20221588
NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
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Ms4a6a
membrane spanning 4-domains A6A
decreases expression
EXP
Astemizole results in decreased expression of MS4A6A mRNA
CTD
PMID:20221588
NCBI chr 1:227,919,284...227,932,637
Ensembl chr 1:227,919,301...227,932,603
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Mtus1
microtubule associated scaffold protein 1
decreases expression
EXP
Astemizole results in decreased expression of MTUS1 mRNA
CTD
PMID:20221588
NCBI chr16:54,240,892...54,386,131
Ensembl chr16:54,291,251...54,386,129
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Myh6
myosin heavy chain 6
increases expression
EXP
Astemizole results in increased expression of MYH6 mRNA
CTD
PMID:20221588
NCBI chr15:33,605,653...33,629,730
Ensembl chr15:33,605,654...33,629,699
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Ndufs7
NADH:ubiquinone oxidoreductase core subunit S7
increases expression
EXP
Astemizole results in increased expression of NDUFS7 mRNA
CTD
PMID:20221588
NCBI chr 7:12,318,776...12,326,403
Ensembl chr 7:12,318,757...12,326,392
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Ndufv2
NADH:ubiquinone oxidoreductase core subunit V2
increases expression
EXP
Astemizole results in increased expression of NDUFV2 mRNA
CTD
PMID:20221588
NCBI chr 9:113,875,718...113,900,169
Ensembl chr 9:113,875,703...113,900,190
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Necab1
N-terminal EF-hand calcium binding protein 1
decreases expression
EXP
Astemizole results in decreased expression of NECAB1 mRNA
CTD
PMID:20221588
NCBI chr 5:28,507,596...28,737,556
Ensembl chr 5:28,504,558...28,737,719
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Nr4a3
nuclear receptor subfamily 4, group A, member 3
increases expression
EXP
Astemizole results in increased expression of NR4A3 mRNA
CTD
PMID:20221588
NCBI chr 5:63,781,801...63,822,890
Ensembl chr 5:63,781,801...63,821,637
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Oasl
2'-5'-oligoadenylate synthetase-like
decreases expression
EXP
Astemizole results in decreased expression of OASL1 mRNA
CTD
PMID:20221588
NCBI chr12:47,444,138...47,456,680
Ensembl chr12:47,444,104...47,456,894
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Osbpl3
oxysterol binding protein-like 3
increases expression
EXP
Astemizole results in increased expression of OSBPL3 mRNA
CTD
PMID:20221588
NCBI chr 4:80,025,453...80,202,532
Ensembl chr 4:80,025,440...80,107,884
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Osgepl1
O-sialoglycoprotein endopeptidase-like 1
increases expression
EXP
Astemizole results in increased expression of OSGEPL1 mRNA
CTD
PMID:20221588
NCBI chr 9:53,084,042...53,098,029
Ensembl chr 9:53,084,045...53,097,979
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Park7
Parkinsonism associated deglycase
increases expression
EXP
Astemizole results in increased expression of PARK7 mRNA
CTD
PMID:20221588
NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
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Pcdh17
protocadherin 17
decreases expression
EXP
Astemizole results in decreased expression of PCDH17 mRNA
CTD
PMID:20221588
NCBI chr15:67,555,835...67,647,990
Ensembl chr15:67,555,835...67,645,088
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Peli2
pellino E3 ubiquitin protein ligase family member 2
increases expression
EXP
Astemizole results in increased expression of PELI2 mRNA
CTD
PMID:20221588
NCBI chr15:24,942,218...25,086,350
Ensembl chr15:24,942,218...25,083,931
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Prl8a3
prolactin family 8, subfamily a, member 3
decreases expression
EXP
Astemizole results in decreased expression of PRL8A3 mRNA
CTD
PMID:20221588
NCBI chr17:39,455,865...39,463,715
Ensembl chr17:39,455,908...39,462,629
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Psmb5
proteasome 20S subunit beta 5
increases expression
EXP
Astemizole results in increased expression of PSMB5 mRNA
CTD
PMID:20221588
NCBI chr15:33,259,039...33,263,634
Ensembl chr15:33,259,043...33,263,659
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Ptgs1
prostaglandin-endoperoxide synthase 1
decreases expression
EXP
Astemizole results in decreased expression of PTGS1 mRNA
CTD
PMID:20221588
NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
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Pycr3
pyrroline-5-carboxylate reductase 3
increases expression
EXP
Astemizole results in increased expression of PYCR3 mRNA
CTD
PMID:20221588
NCBI chr 7:116,949,882...116,955,150
Ensembl chr 7:116,949,879...116,955,148
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Pygm
glycogen phosphorylase, muscle associated
increases expression
EXP
Astemizole results in increased expression of PYGM mRNA
CTD
PMID:20221588
NCBI chr 1:221,756,325...221,771,142
Ensembl chr 1:221,756,286...221,771,143
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S100a8
S100 calcium binding protein A8
increases expression
EXP
Astemizole results in increased expression of S100A8 mRNA
CTD
PMID:20221588
NCBI chr 2:190,073,239...190,074,333
Ensembl chr 2:190,073,815...190,074,354
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S100b
S100 calcium binding protein B
decreases expression
EXP
Astemizole results in decreased expression of S100B mRNA
CTD
PMID:20221588
NCBI chr20:13,130,633...13,142,856
Ensembl chr20:13,130,636...13,142,856
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Sik1
salt-inducible kinase 1
decreases expression
EXP
Astemizole results in decreased expression of SIK1 mRNA
CTD
PMID:20221588
NCBI chr20:10,670,747...10,680,279
Ensembl chr20:10,668,411...10,680,283
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Slc1a1
solute carrier family 1 member 1
increases expression
EXP
Astemizole results in increased expression of SLC1A1 mRNA
CTD
PMID:20221588
NCBI chr 1:246,955,017...247,035,159
Ensembl chr 1:246,954,980...247,037,056
G
Sod2
superoxide dismutase 2
increases expression
EXP
Astemizole results in increased expression of SOD2 mRNA
CTD
PMID:20221588
NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
G
Sqstm1
sequestosome 1
increases expression
EXP
Astemizole results in increased expression of SQSTM1 mRNA
CTD
PMID:20221588
NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
G
Tf
transferrin
decreases expression
EXP
Astemizole results in decreased expression of TF mRNA
CTD
PMID:20221588
NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
G
Tgfb2
transforming growth factor, beta 2
increases expression
EXP
Astemizole results in increased expression of TGFB2 mRNA
CTD
PMID:20221588
NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
G
Tlr2
toll-like receptor 2
decreases expression
EXP
Astemizole results in decreased expression of TLR2 mRNA
CTD
PMID:20221588
NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
G
Tlr7
toll-like receptor 7
decreases expression
EXP
Astemizole results in decreased expression of TLR7 mRNA
CTD
PMID:20221588
NCBI chr X:28,486,836...28,513,004
Ensembl chr X:28,486,869...28,512,957
G
Tmod1
tropomodulin 1
increases expression
EXP
Astemizole results in increased expression of TMOD1 mRNA
CTD
PMID:20221588
NCBI chr 5:61,635,244...61,712,052
Ensembl chr 5:61,657,507...61,712,051
G
Vcam1
vascular cell adhesion molecule 1
multiple interactions
ISO
Astemizole inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]
CTD
PMID:17517105
NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
G
Vcan
versican
decreases expression
EXP
Astemizole results in decreased expression of VCAN mRNA
CTD
PMID:20221588
NCBI chr 2:18,490,102...18,587,340
Ensembl chr 2:18,490,102...18,565,842
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