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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:5alpha-pregnane-3,20-dione
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Accession:CHEBI:28952 term browser browse the term
Definition:A C21-steroid hormone that is 5alpha-pregnane substituted by oxo groups at positions 3 and 20. It is a metabolite of progestrone.
Synonyms:related_synonym: 3,20-allopregnanedione;   3,20-dioxo-5alpha-pregnane;   5-alpha-dihydroprogesterone;   5alpha-dihydroprogesterone;   Formula=C21H32O2;   InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14,16-19H,4-12H2,1-3H3/t14-,16-,17+,18-,19-,20-,21+/m0/s1;   InChIKey=XMRPGKVKISIQBV-BJMCWZGWSA-N;   SMILES=[H][C@@]12CC[C@@]3([H])[C@]4([H])CC[C@H](C(C)=O)[C@@]4(C)CC[C@]3([H])[C@@]1(C)CCC(=O)C2
 alt_id: CHEBI:12175;   CHEBI:20657;   CHEBI:2144
 xref: CAS:566-65-4;   HMDB:HMDB0003759;   KEGG:C03681;   LIPID_MAPS_instance:LMST02030170
 xref_mesh: MESH:D043582
 xref: PMID:15319353;   PMID:17683929;   PMID:19931389;   Reaxys:2058506;   Wikipedia:5%CE%B1-Dihydroprogesterone


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5alpha-pregnane-3,20-dione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 affects reduction ISO AKR1C4 protein affects the reduction of 5-alpha-Dihydroprogesterone CTD PMID:12604236 NCBI chr17:69,441,253...69,460,334
Ensembl chr17:69,441,223...69,460,321
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 affects reduction
increases reduction
ISO AKR1C2 protein affects the reduction of 5-alpha-Dihydroprogesterone
AKR1C2 protein results in increased reduction of 5-alpha-Dihydroprogesterone
CTD PMID:11995921, PMID:12604236 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases chemical synthesis ISO AKR1C3 protein results in increased chemical synthesis of 5-alpha-Dihydroprogesterone CTD PMID:25463305 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 increases chemical synthesis
multiple interactions
ISO AKR1D1 protein results in increased chemical synthesis of 5-alpha-Dihydroprogesterone
AKR1D1 protein alternative form results in increased chemical synthesis of 5-alpha-Dihydroprogesterone
[AKR1D1 protein alternative form results in increased reduction of Progesterone] which results in increased chemical synthesis of 5-alpha-Dihydroprogesterone
CTD PMID:18624455, PMID:30928400 NCBI chr 4:65,110,706...65,143,930
Ensembl chr 4:65,110,746...65,143,941
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
ISO 3-hydroxypregn-4-en-20-one inhibits the reaction [5-alpha-Dihydroprogesterone results in increased expression of BCL2 mRNA] CTD PMID:19931389 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases hydroxylation ISO CYP17A1 protein results in increased hydroxylation of 5-alpha-Dihydroprogesterone CTD PMID:14522586 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Egr2 early growth response 2 increases expression EXP 5-alpha-Dihydroprogesterone results in increased expression of EGR2 mRNA; 5-alpha-Dihydroprogesterone results in increased expression of EGR2 protein CTD PMID:17478888 NCBI chr20:22,452,170...22,461,018
Ensembl chr20:22,454,463...22,459,025
JBrowse link
G Esr1 estrogen receptor 1 increases expression ISO 5-alpha-Dihydroprogesterone results in increased expression of ESR1 mRNA CTD PMID:17683929 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression EXP 5-alpha-Dihydroprogesterone results in decreased expression of GSK3B protein CTD PMID:17443805 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Mapt microtubule-associated protein tau decreases expression
increases phosphorylation
EXP 5-alpha-Dihydroprogesterone results in decreased expression of MAPT protein
5-alpha-Dihydroprogesterone results in increased phosphorylation of MAPT protein
CTD PMID:17443805 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 affects activity
multiple interactions
ISO 5-alpha-Dihydroprogesterone affects the activity of NR1I2 protein
5-alpha-Dihydroprogesterone binds to and results in increased activity of NR1I2 protein
NR1I2 protein affects the susceptibility to [5-alpha-Dihydroprogesterone co-treated with Methacholine Chloride]; NR1I2 protein affects the susceptibility to [5-alpha-Dihydroprogesterone co-treated with N-methylsulfonyl-6-(2-propargyloxyphenyl)hexanamide]
CTD PMID:15846226, PMID:16054614, PMID:17159084, PMID:21291553 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO 5-alpha-Dihydroprogesterone results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Sox10 SRY-box transcription factor 10 increases expression EXP 5-alpha-Dihydroprogesterone results in increased expression of SOX10 mRNA; 5-alpha-Dihydroprogesterone results in increased expression of SOX10 protein CTD PMID:17478888 NCBI chr 7:120,393,238...120,403,523
Ensembl chr 7:120,393,254...120,403,523
JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 multiple interactions
increases chemical synthesis
ISO [SRD5A1 protein results in increased metabolism of Progesterone] which results in increased chemical synthesis of 5-alpha-Dihydroprogesterone
SRD5A1 protein results in increased chemical synthesis of 5-alpha-Dihydroprogesterone
CTD PMID:23183084, PMID:25463305 NCBI chr 1:36,320,504...36,354,694
Ensembl chr 1:36,320,461...36,354,756
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      group 19696
        organic group 18493
          3-oxo-Delta(4)-steroid group 7934
            3-oxo-Delta(4) steroid 7934
              progesterone 2707
                5alpha-pregnane-3,20-dione 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      ketone 16140
                                        oxo steroid 9275
                                          3-oxo steroid 8805
                                            3-oxo-Delta(4) steroid 7934
                                              progesterone 2707
                                                5alpha-pregnane-3,20-dione 14
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