The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
A dimethylxanthine having the two methyl groups located at positions 3 and 7. A purine alkaloid derived from the cacao plant, it is found in chocolate, as well as in a number of other foods, and is a vasodilator, diuretic and heart stimulator.
[Theobromine co-treated with Theanine] inhibits the reaction [1,2-dimethylhydrazine increases expression and phosphorylation of Akt1 mRNA and protein, respectively in the colon]
CYP1A2 protein results in increased metabolism of Theobromine CYP1A2 protein results in increased chemical synthesis of Theobromine [CYP1A2 protein binds to and results in increased metabolism of Caffeine] which results in increased chemical synthesis of Theobromine; furafylline affects the reaction [CYP1A2 protein results in increased metabolism of Theobromine]
4-nitrophenol inhibits the reaction [CYP2E1 protein results in increased metabolism of Theobromine]; Ditiocarb inhibits the reaction [CYP2E1 protein results in increased metabolism of Theobromine] CYP2E1 protein results in increased chemical synthesis of Theobromine
[Theobromine co-treated with Theanine] inhibits the reaction [1,2-dimethylhydrazine increases expression and phosphorylation of Jak2 mRNA and protein, respectively in the colon]
[Theobromine co-treated with Theanine] inhibits the reaction [1,2-dimethylhydrazine increases expression and phosphorylation of Mtor mRNA and protein, respectively in the colon]
[Theobromine co-treated with Theanine] inhibits the reaction [1,2-dimethylhydrazine increases expression and phosphorylation of Rps6kb1 mRNA and protein, respectively in the colon]
[Theobromine co-treated with Theanine] inhibits the reaction [1,2-dimethylhydrazine decreases expression and phosphorylation of Smad2 mRNA and protein, respectively in the colon]
[Theobromine co-treated with Theanine] inhibits the reaction [1,2-dimethylhydrazine increases expression and phosphorylation of Stat3 mRNA and protein, respectively in the colon]
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