Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:mechlorethamine
go back to main search page
Accession:CHEBI:28925 term browser browse the term
Definition:A nitrogen mustard that has formula C5H11Cl2N.
Synonyms:exact_synonym: 2-chloro-N-(2-chloroethyl)-N-methylethanamine
 related_synonym: 2,2'-dichloro-N-methyldiethylamine;   Formula=C5H11Cl2N;   InChI=1S/C5H11Cl2N/c1-8(4-2-6)5-3-7/h2-5H2,1H3;   InChIKey=HAWPXGHAZFHHAD-UHFFFAOYSA-N;   N-methyl-bis(2-chloroethyl)amine;   N-methyl-bis(beta-chloroethyl)amine;   SMILES=CN(CCCl)CCCl;   beta,beta'-dichlorodiethyl-N-methylamine;   bis(2-chloroethyl)methylamine;   bis(beta-chloroethyl)methylamine;   chlormethine;   methylbis(2-chloroethyl)amine;   methylbis(beta-chloroethyl)amine;   nitrogen mustard
 alt_id: CHEBI:25557;   CHEBI:6708
 xref: CAS:51-75-2;   DrugBank:DB00888;   Drug_Central:1647;   KEGG:C07115;   KEGG:D07671
 xref_mesh: MESH:D008466
 xref: Wikipedia:Mechlorethamine



show annotations for term's descendants           Sort by:
 
mechlorethamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a multiple interactions
increases expression
EXP Valproic Acid promotes the reaction [Mechlorethamine results in increased expression of AGTR1A mRNA] CTD PMID:28184907 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression ISO Mechlorethamine results in increased expression of AIFM1 mRNA CTD PMID:17107856 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Ampd3 adenosine monophosphate deaminase 3 increases expression ISO Mechlorethamine results in increased expression of AMPD3 mRNA CTD PMID:17107856 NCBI chr 1:164,884,823...164,929,899
Ensembl chr 1:164,885,320...164,929,887
JBrowse link
G Apcs amyloid P component, serum increases expression EXP Mechlorethamine results in increased expression of APCS mRNA CTD PMID:26273949 NCBI chr13:85,373,338...85,374,134
Ensembl chr13:85,373,220...85,374,298
JBrowse link
G Apoe apolipoprotein E multiple interactions
increases expression
EXP Valproic Acid promotes the reaction [Mechlorethamine results in increased expression of APOE mRNA] CTD PMID:26273949 PMID:28184907 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 decreases expression ISO Mechlorethamine results in decreased expression of ATP1A2 mRNA CTD PMID:17107856 NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO Mechlorethamine results in increased expression of BAK1 protein CTD PMID:22285227 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Mechlorethamine results in increased expression of and results in decreased localization of BAX protein; Mechlorethamine results in increased expression of and results in increased activity of BAX protein CTD PMID:16738803 PMID:22285227 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Mechlorethamine results in decreased expression of BCL2 protein CTD PMID:16738803 PMID:22285227 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Calm3 calmodulin 3 decreases expression ISO Mechlorethamine results in decreased expression of CALM3 mRNA CTD PMID:17107856 NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207
JBrowse link
G Casp2 caspase 2 increases activity ISO Mechlorethamine results in increased activity of CASP2 protein CTD PMID:16738803 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO Mechlorethamine results in increased activity of CASP3 protein
ebselen inhibits the reaction [Mechlorethamine results in increased activity of CASP3 protein]
CTD PMID:23649643 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
ISO Mechlorethamine results in increased activity of CASP9 protein
ebselen inhibits the reaction [Mechlorethamine results in increased activity of CASP9 protein]; Mechlorethamine results in increased cleavage of and results in increased activity of CASP9 protein
CTD PMID:16738803 PMID:22285227 PMID:23649643 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression EXP Mechlorethamine results in increased expression of CCL2 mRNA CTD PMID:26273949 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression EXP Mechlorethamine results in increased expression of CCL5 mRNA CTD PMID:26273949 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression EXP Mechlorethamine results in increased expression of CCN2 mRNA; Mechlorethamine results in increased expression of CCN2 protein CTD PMID:20883710 PMID:26273949 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Ccna2 cyclin A2 multiple interactions
increases stability
ISO Mechlorethamine results in decreased activity of [CCNA2 protein binds to CDK2 protein]; Mechlorethamine results in increased expression of and results in increased activity of [CDK2 protein binds to CCNA2 protein]; Pentoxifylline inhibits the reaction [Mechlorethamine results in increased activity of [CCNA2 protein binds to CDK2 protein]]
Mechlorethamine results in increased stability of CCNA2 protein
CTD PMID:8463339 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 decreases activity
multiple interactions
ISO Mechlorethamine results in decreased activity of CCNB1 protein
Mechlorethamine results in decreased activity of [CCNB1 protein binds to CDK1 protein]; Pentoxifylline inhibits the reaction [Mechlorethamine results in decreased activity of [CCNB1 protein binds to CDK1 protein]]
CTD PMID:8463339 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 multiple interactions
increases expression
EXP Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of CCR2 mRNA]
Mechlorethamine results in increased expression of CCR2 mRNA; Mechlorethamine results in increased expression of CCR2 protein
CTD PMID:26273949 PMID:28184907 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
JBrowse link
G Ccr5 C-C motif chemokine receptor 5 increases expression EXP Mechlorethamine results in increased expression of CCR5 mRNA CTD PMID:26273949 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
JBrowse link
G Cd163 CD163 molecule increases expression EXP Mechlorethamine results in increased expression of CD163 protein CTD PMID:26273949 NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878
JBrowse link
G Cd68 Cd68 molecule increases expression EXP Mechlorethamine results in increased expression of CD68 protein CTD PMID:26273949 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions
increases stability
decreases activity
ISO Mechlorethamine results in decreased activity of [CCNB1 protein binds to CDK1 protein]; Pentoxifylline inhibits the reaction [Mechlorethamine results in decreased activity of [CCNB1 protein binds to CDK1 protein]]
Mechlorethamine results in increased stability of CDK1 protein modified form
Mechlorethamine results in decreased activity of CDK1 protein
CTD PMID:8463339 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk2 cyclin dependent kinase 2 increases activity
multiple interactions
ISO Mechlorethamine results in increased activity of CDK2 protein
Mechlorethamine results in decreased activity of [CCNA2 protein binds to CDK2 protein]; Mechlorethamine results in increased expression of and results in increased activity of [CDK2 protein binds to CCNA2 protein]; Pentoxifylline inhibits the reaction [Mechlorethamine results in increased activity of [CCNA2 protein binds to CDK2 protein]]
CTD PMID:8463339 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cnr1 cannabinoid receptor 1 increases expression ISO Mechlorethamine results in increased expression of CNR1 protein CTD PMID:27125198 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Cnr2 cannabinoid receptor 2 increases expression ISO Mechlorethamine results in increased expression of CNR2 protein CTD PMID:27125198 NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 increases expression EXP Mechlorethamine results in increased expression of CX3CL1 mRNA CTD PMID:26273949 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 increases expression
multiple interactions
EXP Mechlorethamine results in increased expression of CX3CR1 mRNA; Mechlorethamine results in increased expression of CX3CR1 protein
Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of CX3CR1 mRNA]
CTD PMID:26273949 PMID:28184907 NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 affects response to substance ISO CXCR2 protein affects the susceptibility to Mechlorethamine CTD PMID:12753603 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO Mechlorethamine results in increased expression of CXCR4 mRNA CTD PMID:17107856 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 decreases expression ISO Mechlorethamine results in decreased expression of ERBB2 protein CTD PMID:17932452 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Faah fatty acid amide hydrolase increases expression ISO Mechlorethamine results in increased expression of FAAH protein CTD PMID:27125198 NCBI chr 5:129,479,774...129,499,018 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Mechlorethamine results in increased expression of and affects the localization of FOS protein; Mechlorethamine results in increased phosphorylation of and results in increased expression of FOS protein
FOS protein affects the reaction [Mechlorethamine results in increased secretion of CXCL8 protein]
CTD PMID:25891025 PMID:31639410 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO FOSB protein affects the reaction [Mechlorethamine results in increased secretion of CXCL8 protein]; FOSL1 protein affects the reaction [Mechlorethamine results in increased expression of and affects the localization of FOSB protein]; Mechlorethamine results in increased expression of and affects the localization of FOSB protein; U 0126 inhibits the reaction [Mechlorethamine results in increased expression of FOSB protein] CTD PMID:31639410 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression
multiple interactions
ISO Mechlorethamine results in increased expression of FOSL1 protein
FOSL1 protein affects the reaction [Mechlorethamine results in increased expression of and affects the localization of FOSB protein]; FOSL1 protein affects the reaction [Mechlorethamine results in increased expression of CXCL8 mRNA]; FOSL1 protein affects the reaction [Mechlorethamine results in increased secretion of CXCL8 protein]; Mechlorethamine promotes the reaction [FOSL1 protein binds to JUN protein]; Mechlorethamine promotes the reaction [FOSL1 protein binds to JUNB protein]; Mechlorethamine promotes the reaction [FOSL1 protein binds to JUND protein]; Mechlorethamine results in increased expression of and affects the localization of FOSL1 protein; U 0126 inhibits the reaction [Mechlorethamine results in increased expression of FOSL1 protein]
CTD PMID:31639410 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit increases expression
multiple interactions
ISO Mechlorethamine results in increased expression of FOSL2 protein
FOSL2 protein affects the reaction [Mechlorethamine results in increased secretion of CXCL8 protein]
CTD PMID:31639410 NCBI chr 6:24,297,898...24,319,157
Ensembl chr 6:24,300,956...24,320,034
JBrowse link
G Gdf9 growth differentiation factor 9 increases expression ISO Mechlorethamine results in increased expression of GDF9 mRNA CTD PMID:17107856 NCBI chr10:37,589,200...37,599,970
Ensembl chr10:37,595,679...37,599,672
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 decreases response to substance
increases expression
ISO GSTA2 protein results in decreased susceptibility to Mechlorethamine
Mechlorethamine results in increased expression of GSTA2 mRNA
CTD PMID:15778998 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 decreases response to substance EXP GSTA3 protein results in decreased susceptibility to Mechlorethamine CTD PMID:8044793 PMID:8860835 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
JBrowse link
G H2ax H2A.X variant histone increases expression ISO Mechlorethamine results in increased expression of H2AX protein modified form CTD PMID:25891025 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hdac2 histone deacetylase 2 multiple interactions
increases expression
EXP Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of HDAC2 protein] CTD PMID:28184907 NCBI chr20:40,548,250...40,571,609
Ensembl chr20:40,548,250...40,571,609
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP
ISO
Mechlorethamine results in increased expression of HMOX1; Mechlorethamine results in increased expression of HMOX1 protein
SFTPD gene mutant form promotes the reaction [Mechlorethamine results in increased expression of HMOX1 protein]
Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of HMOX1 protein]
CTD PMID:22981630 PMID:28184907 PMID:30060251 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il10 interleukin 10 increases expression
multiple interactions
EXP Mechlorethamine results in increased expression of IL10 mRNA
Valproic Acid promotes the reaction [Mechlorethamine results in increased expression of IL10 mRNA]
CTD PMID:26273949 PMID:28184907 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il12a interleukin 12A increases expression EXP Mechlorethamine results in increased expression of IL12A mRNA CTD PMID:26273949 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B increases expression
multiple interactions
EXP Mechlorethamine results in increased expression of IL12B mRNA
Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of IL12B mRNA]
CTD PMID:28184907 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Itgam integrin subunit alpha M increases expression EXP Mechlorethamine results in increased expression of ITGAM protein CTD PMID:26273949 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Jag1 jagged canonical Notch ligand 1 increases expression ISO Mechlorethamine results in increased expression of JAG1 mRNA CTD PMID:17107856 NCBI chr 3:124,406,794...124,442,220
Ensembl chr 3:124,406,794...124,442,209
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation
multiple interactions
increases expression
ISO Mechlorethamine results in increased phosphorylation of JUN protein
Mechlorethamine results in increased expression of and affects the localization of JUN protein
Mechlorethamine results in increased expression of JUN protein
Mechlorethamine promotes the reaction [FOSL1 protein binds to JUN protein]; U 0126 inhibits the reaction [Mechlorethamine results in increased expression of JUN protein]
CTD PMID:25891025 PMID:31639410 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO Mechlorethamine promotes the reaction [FOSL1 protein binds to JUNB protein]; U 0126 inhibits the reaction [Mechlorethamine results in increased expression of JUNB protein]
Mechlorethamine results in increased expression of and affects the localization of JUNB protein
CTD PMID:31639410 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO Mechlorethamine promotes the reaction [FOSL1 protein binds to JUND protein]; U 0126 inhibits the reaction [Mechlorethamine results in increased expression of JUND protein]
Mechlorethamine results in increased expression of and affects the localization of JUND protein
CTD PMID:31639410 NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799
JBrowse link
G Lamc2 laminin subunit gamma 2 decreases expression
increases degradation
ISO Mechlorethamine results in decreased expression of LAMC2 protein
Mechlorethamine results in increased degradation of LAMC2 protein
CTD PMID:9504665 PMID:18095945 NCBI chr13:65,284,664...65,344,200
Ensembl chr13:65,284,664...65,344,200
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO Mechlorethamine results in increased phosphorylation of MAPK1 protein
Mechlorethamine results in increased phosphorylation of and affects the localization of MAPK1 protein
CTD PMID:25891025 PMID:31639410 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO Mechlorethamine results in increased phosphorylation of MAPK3 protein
Mechlorethamine results in increased phosphorylation of and affects the localization of MAPK3 protein
CTD PMID:25891025 PMID:31639410 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO Mechlorethamine results in increased phosphorylation of MAPK8 protein CTD PMID:25891025 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO Mechlorethamine results in increased phosphorylation of MAPK9 protein CTD PMID:25891025 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mmp10 matrix metallopeptidase 10 increases expression EXP Mechlorethamine results in increased expression of MMP10 mRNA CTD PMID:26273949 NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
multiple interactions
ISO
EXP
Mechlorethamine results in increased expression of MMP9; Mechlorethamine results in increased expression of MMP9 protein
Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of MMP9 mRNA]
Mechlorethamine results in increased expression of MMP9 mRNA; Mechlorethamine results in increased expression of MMP9 protein
MPO gene mutant form inhibits the reaction [Mechlorethamine results in increased expression of MMP9]; SFTPD gene mutant form promotes the reaction [Mechlorethamine results in increased expression of MMP9 protein]
CTD PMID:20883710 PMID:24631667 PMID:25891025 PMID:26273949 PMID:28184907 More... NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mobp myelin-associated oligodendrocyte basic protein decreases expression ISO Mechlorethamine results in decreased expression of MOBP mRNA CTD PMID:17107856 NCBI chr 8:119,869,504...119,899,605
Ensembl chr 8:119,869,626...119,899,563
JBrowse link
G Mpo myeloperoxidase multiple interactions
increases response to substance
ISO MPO gene mutant form inhibits the reaction [Mechlorethamine results in increased expression of MMP9]; MPO gene mutant form inhibits the reaction [Mechlorethamine results in increased expression of NOS2]; MPO gene mutant form inhibits the reaction [Mechlorethamine results in increased expression of PTGS2]
MPO protein results in increased susceptibility to Mechlorethamine
CTD PMID:24631667 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mrc1 mannose receptor, C type 1 increases expression
multiple interactions
EXP
ISO
Mechlorethamine results in increased expression of MRC1 protein
SFTPD gene mutant form promotes the reaction [Mechlorethamine results in increased expression of MRC1 protein]
CTD PMID:26273949 PMID:30060251 NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857
JBrowse link
G Msh2 mutS homolog 2 affects response to substance ISO MSH2 protein affects the susceptibility to Mechlorethamine CTD PMID:12185594 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938
JBrowse link
G Nckap1 NCK-associated protein 1 decreases expression ISO Mechlorethamine results in decreased expression of NCKAP1 mRNA CTD PMID:17107856 NCBI chr 3:65,417,450...65,491,769
Ensembl chr 3:65,417,453...65,492,217
JBrowse link
G Ndrg2 NDRG family member 2 decreases expression ISO Mechlorethamine results in decreased expression of NDRG2 mRNA CTD PMID:17107856 NCBI chr15:24,600,981...24,609,621
Ensembl chr15:24,600,982...24,609,626
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects response to substance
decreases response to substance
ISO NFE2L2 gene mutant form affects the susceptibility to Mechlorethamine
NFE2L2 protein results in decreased susceptibility to Mechlorethamine
CTD PMID:20932822 PMID:26454883 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nmu neuromedin U increases expression ISO Mechlorethamine results in increased expression of NMU mRNA CTD PMID:17107856 NCBI chr14:31,844,564...31,872,196
Ensembl chr14:31,844,728...31,872,192
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
ISO
EXP
Mechlorethamine results in increased expression of NOS2; Mechlorethamine results in increased expression of NOS2 protein
Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of NOS2 mRNA]
Mechlorethamine results in increased expression of NOS2 mRNA; Mechlorethamine results in increased expression of NOS2 protein
MPO gene mutant form inhibits the reaction [Mechlorethamine results in increased expression of NOS2]; SFTPD gene mutant form promotes the reaction [Mechlorethamine results in increased expression of NOS2 protein]
CTD PMID:20883710 PMID:24631667 PMID:25891025 PMID:26273949 PMID:28184907 More... NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression
multiple interactions
EXP Mechlorethamine results in increased expression of PCNA; Mechlorethamine results in increased expression of PCNA protein
Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of PCNA protein]
CTD PMID:22981630 PMID:28184907 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pdcd4 programmed cell death 4 increases expression ISO Mechlorethamine results in increased expression of PDCD4 mRNA CTD PMID:17107856 NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 increases expression ISO Mechlorethamine results in increased expression of PDPK1 protein modified form CTD PMID:25891025 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623
JBrowse link
G Plp1 proteolipid protein 1 decreases expression ISO Mechlorethamine results in decreased expression of PLP1 mRNA CTD PMID:17107856 NCBI chr  X:100,184,039...100,201,035
Ensembl chr  X:100,185,767...100,201,032
JBrowse link
G Polr2j RNA polymerase II subunit J decreases expression ISO Mechlorethamine results in decreased expression of POLR2J mRNA CTD PMID:17107856 NCBI chr12:20,543,038...20,548,590
Ensembl chr12:20,543,038...20,548,594
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO Mechlorethamine results in increased expression of PPARA protein CTD PMID:27125198 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Psmd11 proteasome 26S subunit, non-ATPase 11 increases expression ISO Mechlorethamine results in increased expression of PSMD11 mRNA CTD PMID:17107856 NCBI chr10:65,433,853...65,479,774
Ensembl chr10:65,433,853...65,479,766
JBrowse link
G Psmd7 proteasome 26S subunit, non-ATPase 7 increases expression ISO Mechlorethamine results in increased expression of PSMD7 mRNA CTD PMID:17107856 NCBI chr19:35,494,317...35,501,605
Ensembl chr19:35,494,316...35,501,588
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO
EXP
Mechlorethamine results in increased expression of PTGS2; Mechlorethamine results in increased expression of PTGS2 protein
Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of PTGS2 mRNA]
MPO gene mutant form inhibits the reaction [Mechlorethamine results in increased expression of PTGS2]
Mechlorethamine results in increased expression of PTGS2 mRNA; Mechlorethamine results in increased expression of PTGS2 protein
CTD PMID:20883710 PMID:24631667 PMID:25891025 PMID:26273949 PMID:28184907 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rad51 RAD51 recombinase increases expression ISO Mechlorethamine results in increased expression of RAD51 protein CTD PMID:25891025 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
JBrowse link
G Sem1 SEM1 26S proteasome subunit increases expression ISO Mechlorethamine results in increased expression of SEM1 mRNA CTD PMID:17107856 NCBI chr 4:34,671,848...34,692,005
Ensembl chr 4:34,671,848...34,692,005
JBrowse link
G Sftpd surfactant protein D increases expression
increases response to substance
multiple interactions
ISO Mechlorethamine results in increased expression of SFTPD protein
SFTPD gene mutant form results in increased susceptibility to Mechlorethamine
SFTPD gene mutant form promotes the reaction [Mechlorethamine results in increased expression of CHIL3 protein]; SFTPD gene mutant form promotes the reaction [Mechlorethamine results in increased expression of HMOX1 protein]; SFTPD gene mutant form promotes the reaction [Mechlorethamine results in increased expression of MMP9 protein]; SFTPD gene mutant form promotes the reaction [Mechlorethamine results in increased expression of MRC1 protein]; SFTPD gene mutant form promotes the reaction [Mechlorethamine results in increased expression of NOS2 protein]
CTD PMID:30060251 NCBI chr16:17,046,491...17,058,968
Ensembl chr16:17,046,483...17,059,927
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Mechlorethamine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions
EXP Mechlorethamine results in increased expression of SOD2; Mechlorethamine results in increased expression of SOD2 protein
Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of SOD2 protein]
CTD PMID:22981630 PMID:28184907 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Stk11 serine/threonine kinase 11 increases expression ISO Mechlorethamine results in increased expression of STK11 mRNA CTD PMID:17107856 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315
JBrowse link
G Tnf tumor necrosis factor increases expression ISO
EXP
Mechlorethamine results in increased expression of TNF protein
Mechlorethamine results in increased expression of TNF mRNA; Mechlorethamine results in increased expression of TNF protein
CTD PMID:25891025 PMID:26243812 PMID:26273949 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf12a TNF receptor superfamily member 12A decreases expression ISO Mechlorethamine results in decreased expression of TNFRSF12A mRNA CTD PMID:17107856 NCBI chr10:12,707,077...12,709,071
Ensembl chr10:12,689,890...12,709,045
JBrowse link
G Tp53 tumor protein p53 multiple interactions
affects response to substance
increases expression
ISO Mechlorethamine results in increased phosphorylation of and results in increased expression of TRP53 protein
TRP53 affects the susceptibility to Mechlorethamine; TRP53 protein affects the susceptibility to Mechlorethamine
Mechlorethamine results in increased expression of TP53 protein
CTD PMID:12185594 PMID:16738803 PMID:23845566 PMID:25891025 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Txn1 thioredoxin 1 decreases activity ISO Mechlorethamine results in decreased activity of TXN protein CTD PMID:26451472 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions ISO
EXP
[NADP co-treated with Mechlorethamine] results in decreased activity of TXNRD1 protein
[NADP co-treated with Mechlorethamine] promotes the reaction [TXNRD1 protein binds to TXNRD1 protein]; [NADP co-treated with Mechlorethamine] results in decreased activity of and results in increased alkylation of TXNRD1 protein
CTD PMID:24274902 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Txnrd2 thioredoxin reductase 2 decreases activity ISO Mechlorethamine results in decreased activity of TXNRD2 protein CTD PMID:24274902 NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156
JBrowse link
G Ube2k ubiquitin-conjugating enzyme E2K increases expression ISO Mechlorethamine results in increased expression of UBE2K mRNA CTD PMID:17107856 NCBI chr14:42,658,016...42,718,899
Ensembl chr14:42,658,016...42,718,630
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      biological role 19746
        aetiopathogenetic role 19022
          genotoxin 17462
            mutagen 17364
              alkylating agent 14265
                mechlorethamine 88
                  mechlorethamine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      carbon group element atom 19614
                        carbon atom 19604
                          organic molecular entity 19604
                            heteroorganic entity 19273
                              organohalogen compound 17937
                                organochlorine compound 17755
                                  mechlorethamine 88
                                    mechlorethamine hydrochloride 0
paths to the root