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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:mechlorethamine
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Accession:CHEBI:28925 term browser browse the term
Definition:A nitrogen mustard that has formula C5H11Cl2N.
Synonyms:exact_synonym: 2-chloro-N-(2-chloroethyl)-N-methylethanamine
 related_synonym: 2,2'-dichloro-N-methyldiethylamine;   Formula=C5H11Cl2N;   InChI=1S/C5H11Cl2N/c1-8(4-2-6)5-3-7/h2-5H2,1H3;   InChIKey=HAWPXGHAZFHHAD-UHFFFAOYSA-N;   N-methyl-bis(2-chloroethyl)amine;   N-methyl-bis(beta-chloroethyl)amine;   SMILES=CN(CCCl)CCCl;   beta,beta'-dichlorodiethyl-N-methylamine;   bis(2-chloroethyl)methylamine;   bis(beta-chloroethyl)methylamine;   chlormethine;   methylbis(2-chloroethyl)amine;   methylbis(beta-chloroethyl)amine;   nitrogen mustard
 alt_id: CHEBI:25557;   CHEBI:6708
 xref: CAS:51-75-2;   DrugBank:DB00888;   Drug_Central:1647;   KEGG:C07115;   KEGG:D07671
 xref_mesh: MESH:D008466
 xref: Wikipedia:Mechlorethamine


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mechlorethamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a multiple interactions
increases expression
EXP Valproic Acid promotes the reaction [Mechlorethamine results in increased expression of AGTR1A mRNA] CTD PMID:28184907 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression ISO Mechlorethamine results in increased expression of AIFM1 mRNA CTD PMID:17107856 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Ampd3 adenosine monophosphate deaminase 3 increases expression ISO Mechlorethamine results in increased expression of AMPD3 mRNA CTD PMID:17107856 NCBI chr 1:175,585,301...175,630,479
Ensembl chr 1:175,586,097...175,630,467
JBrowse link
G Apcs amyloid P component, serum increases expression EXP Mechlorethamine results in increased expression of APCS mRNA CTD PMID:26273949 NCBI chr13:91,426,621...91,427,417
Ensembl chr13:91,426,479...91,427,575
JBrowse link
G Apoe apolipoprotein E multiple interactions
increases expression
EXP Valproic Acid promotes the reaction [Mechlorethamine results in increased expression of APOE mRNA] CTD PMID:26273949, PMID:28184907 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 decreases expression ISO Mechlorethamine results in decreased expression of ATP1A2 mRNA CTD PMID:17107856 NCBI chr13:90,651,682...90,676,629
Ensembl chr13:90,651,686...90,676,629
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO Mechlorethamine results in increased expression of BAK1 protein CTD PMID:22285227 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Mechlorethamine results in increased expression of and results in decreased localization of BAX protein; Mechlorethamine results in increased expression of and results in increased activity of BAX protein CTD PMID:16738803, PMID:22285227 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Mechlorethamine results in decreased expression of BCL2 protein CTD PMID:16738803, PMID:22285227 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Calm3 calmodulin 3 decreases expression ISO Mechlorethamine results in decreased expression of CALM3 mRNA CTD PMID:17107856 NCBI chr 1:78,844,520...78,851,628
Ensembl chr 1:78,843,080...78,851,719
JBrowse link
G Casp2 caspase 2 increases activity ISO Mechlorethamine results in increased activity of CASP2 protein CTD PMID:16738803 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO Mechlorethamine results in increased activity of CASP3 protein
ebselen inhibits the reaction [Mechlorethamine results in increased activity of CASP3 protein]
CTD PMID:23649643 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
ISO Mechlorethamine results in increased activity of CASP9 protein
ebselen inhibits the reaction [Mechlorethamine results in increased activity of CASP9 protein]; Mechlorethamine results in increased cleavage of and results in increased activity of CASP9 protein
CTD PMID:16738803, PMID:22285227, PMID:23649643 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression EXP Mechlorethamine results in increased expression of CCL2 mRNA CTD PMID:26273949 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression EXP Mechlorethamine results in increased expression of CCL5 mRNA CTD PMID:26273949 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression EXP Mechlorethamine results in increased expression of CCN2 mRNA; Mechlorethamine results in increased expression of CCN2 protein CTD PMID:20883710, PMID:26273949 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccna2 cyclin A2 multiple interactions
increases stability
ISO Mechlorethamine results in decreased activity of [CCNA2 protein binds to CDK2 protein]; Mechlorethamine results in increased expression of and results in increased activity of [CDK2 protein binds to CCNA2 protein]; Pentoxifylline inhibits the reaction [Mechlorethamine results in increased activity of [CCNA2 protein binds to CDK2 protein]]
Mechlorethamine results in increased stability of CCNA2 protein
CTD PMID:8463339 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 decreases activity
multiple interactions
ISO Mechlorethamine results in decreased activity of CCNB1 protein
Mechlorethamine results in decreased activity of [CCNB1 protein binds to CDK1 protein]; Pentoxifylline inhibits the reaction [Mechlorethamine results in decreased activity of [CCNB1 protein binds to CDK1 protein]]
CTD PMID:8463339 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 multiple interactions
increases expression
EXP Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of CCR2 mRNA]
Mechlorethamine results in increased expression of CCR2 mRNA; Mechlorethamine results in increased expression of CCR2 protein
CTD PMID:26273949, PMID:28184907
G Ccr5 C-C motif chemokine receptor 5 increases expression EXP Mechlorethamine results in increased expression of CCR5 mRNA CTD PMID:26273949 NCBI chr 8:133,192,398...133,215,599
Ensembl chr 8:133,197,032...133,215,614
JBrowse link
G Cd163 CD163 molecule increases expression EXP Mechlorethamine results in increased expression of CD163 protein CTD PMID:26273949 NCBI chr 4:156,752,063...156,785,467
Ensembl chr 4:156,752,082...156,785,467
JBrowse link
G Cd68 Cd68 molecule increases expression EXP Mechlorethamine results in increased expression of CD68 protein CTD PMID:26273949 NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions
increases stability
decreases activity
ISO Mechlorethamine results in decreased activity of [CCNB1 protein binds to CDK1 protein]; Pentoxifylline inhibits the reaction [Mechlorethamine results in decreased activity of [CCNB1 protein binds to CDK1 protein]]
Mechlorethamine results in increased stability of CDK1 protein modified form
Mechlorethamine results in decreased activity of CDK1 protein
CTD PMID:8463339 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk2 cyclin dependent kinase 2 increases activity
multiple interactions
ISO Mechlorethamine results in increased activity of CDK2 protein
Mechlorethamine results in decreased activity of [CCNA2 protein binds to CDK2 protein]; Mechlorethamine results in increased expression of and results in increased activity of [CDK2 protein binds to CCNA2 protein]; Pentoxifylline inhibits the reaction [Mechlorethamine results in increased activity of [CCNA2 protein binds to CDK2 protein]]
CTD PMID:8463339 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cnr1 cannabinoid receptor 1 increases expression ISO Mechlorethamine results in increased expression of CNR1 protein CTD PMID:27125198 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Cnr2 cannabinoid receptor 2 increases expression ISO Mechlorethamine results in increased expression of CNR2 protein CTD PMID:27125198 NCBI chr 5:154,242,010...154,268,126
Ensembl chr 5:154,260,062...154,268,126
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 increases expression EXP Mechlorethamine results in increased expression of CX3CL1 mRNA CTD PMID:26273949 NCBI chr19:10,644,267...10,654,861
Ensembl chr19:10,644,244...10,653,800
JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 increases expression
multiple interactions
EXP Mechlorethamine results in increased expression of CX3CR1 mRNA; Mechlorethamine results in increased expression of CX3CR1 protein
Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of CX3CR1 mRNA]
CTD PMID:26273949, PMID:28184907 NCBI chr 8:128,740,756...128,754,514
Ensembl chr 8:128,740,756...128,754,514
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 affects response to substance ISO CXCR2 protein affects the susceptibility to Mechlorethamine CTD PMID:12753603 NCBI chr 9:81,427,275...81,435,065
Ensembl chr 9:81,427,730...81,434,102
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO Mechlorethamine results in increased expression of CXCR4 mRNA CTD PMID:17107856 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 decreases expression ISO Mechlorethamine results in decreased expression of ERBB2 protein CTD PMID:17932452 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Faah fatty acid amide hydrolase increases expression ISO Mechlorethamine results in increased expression of FAAH protein CTD PMID:27125198 NCBI chr 5:134,852,899...134,872,095
Ensembl chr 5:134,852,875...134,871,775
JBrowse link
G Faahl fatty-acid amide hydrolase-like increases expression ISO Mechlorethamine results in increased expression of FAAH protein CTD PMID:27125198 NCBI chr 5:134,330,204...134,349,400
Ensembl chr 5:134,331,929...134,348,995
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Mechlorethamine results in increased expression of and affects the localization of FOS protein; Mechlorethamine results in increased phosphorylation of and results in increased expression of FOS protein
FOS protein affects the reaction [Mechlorethamine results in increased secretion of CXCL8 protein]
CTD PMID:25891025, PMID:31639410 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO FOSB protein affects the reaction [Mechlorethamine results in increased secretion of CXCL8 protein]; FOSL1 protein affects the reaction [Mechlorethamine results in increased expression of and affects the localization of FOSB protein]; Mechlorethamine results in increased expression of and affects the localization of FOSB protein; U 0126 inhibits the reaction [Mechlorethamine results in increased expression of FOSB protein] CTD PMID:31639410 NCBI chr 1:80,214,691...80,221,417
Ensembl chr 1:80,214,494...80,221,710
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression
multiple interactions
ISO Mechlorethamine results in increased expression of FOSL1 protein
FOSL1 protein affects the reaction [Mechlorethamine results in increased expression of and affects the localization of FOSB protein]; FOSL1 protein affects the reaction [Mechlorethamine results in increased expression of CXCL8 mRNA]; FOSL1 protein affects the reaction [Mechlorethamine results in increased secretion of CXCL8 protein]; Mechlorethamine promotes the reaction [FOSL1 protein binds to JUN protein]; Mechlorethamine promotes the reaction [FOSL1 protein binds to JUNB protein]; Mechlorethamine promotes the reaction [FOSL1 protein binds to JUND protein]; Mechlorethamine results in increased expression of and affects the localization of FOSL1 protein; U 0126 inhibits the reaction [Mechlorethamine results in increased expression of FOSL1 protein]
CTD PMID:31639410 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit increases expression
multiple interactions
ISO Mechlorethamine results in increased expression of FOSL2 protein
FOSL2 protein affects the reaction [Mechlorethamine results in increased secretion of CXCL8 protein]
CTD PMID:31639410 NCBI chr 6:25,598,936...25,616,995
Ensembl chr 6:25,598,936...25,616,995
JBrowse link
G Gdf9 growth differentiation factor 9 increases expression ISO Mechlorethamine results in increased expression of GDF9 mRNA CTD PMID:17107856 NCBI chr10:38,782,519...38,793,238
Ensembl chr10:38,788,992...38,792,940
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 decreases response to substance
increases expression
ISO
EXP
GSTA2 protein results in decreased susceptibility to Mechlorethamine
GSTA3 protein results in decreased susceptibility to Mechlorethamine
Mechlorethamine results in increased expression of GSTA2 mRNA
CTD PMID:8044793, PMID:8860835, PMID:15778998 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G H2ax H2A.X variant histone increases expression ISO Mechlorethamine results in increased expression of H2AX protein modified form CTD PMID:25891025 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hdac2 histone deacetylase 2 multiple interactions
increases expression
EXP Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of HDAC2 protein] CTD PMID:28184907 NCBI chr20:43,084,870...43,108,198
Ensembl chr20:43,084,870...43,108,198
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP
ISO
Mechlorethamine results in increased expression of HMOX1; Mechlorethamine results in increased expression of HMOX1 protein
SFTPD gene mutant form promotes the reaction [Mechlorethamine results in increased expression of HMOX1 protein]
Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of HMOX1 protein]
CTD PMID:22981630, PMID:28184907, PMID:30060251 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il10 interleukin 10 increases expression
multiple interactions
EXP Mechlorethamine results in increased expression of IL10 mRNA
Valproic Acid promotes the reaction [Mechlorethamine results in increased expression of IL10 mRNA]
CTD PMID:26273949, PMID:28184907 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12a interleukin 12A increases expression EXP Mechlorethamine results in increased expression of IL12A mRNA CTD PMID:26273949 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
JBrowse link
G Il12b interleukin 12B increases expression
multiple interactions
EXP Mechlorethamine results in increased expression of IL12B mRNA
Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of IL12B mRNA]
CTD PMID:28184907 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Itgam integrin subunit alpha M increases expression EXP Mechlorethamine results in increased expression of ITGAM protein CTD PMID:26273949 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Jag1 jagged canonical Notch ligand 1 increases expression ISO Mechlorethamine results in increased expression of JAG1 mRNA CTD PMID:17107856 NCBI chr 3:130,079,361...130,114,781
Ensembl chr 3:130,079,361...130,114,770
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation
multiple interactions
increases expression
ISO Mechlorethamine results in increased phosphorylation of JUN protein
Mechlorethamine results in increased expression of and affects the localization of JUN protein
Mechlorethamine results in increased expression of JUN protein
Mechlorethamine promotes the reaction [FOSL1 protein binds to JUN protein]; U 0126 inhibits the reaction [Mechlorethamine results in increased expression of JUN protein]
CTD PMID:25891025, PMID:31639410 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO Mechlorethamine promotes the reaction [FOSL1 protein binds to JUNB protein]; U 0126 inhibits the reaction [Mechlorethamine results in increased expression of JUNB protein]
Mechlorethamine results in increased expression of and affects the localization of JUNB protein
CTD PMID:31639410 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO Mechlorethamine promotes the reaction [FOSL1 protein binds to JUND protein]; U 0126 inhibits the reaction [Mechlorethamine results in increased expression of JUND protein]
Mechlorethamine results in increased expression of and affects the localization of JUND protein
CTD PMID:31639410 NCBI chr16:20,485,028...20,486,707
Ensembl chr16:20,485,029...20,486,707
JBrowse link
G Lamc2 laminin subunit gamma 2 decreases expression
increases degradation
ISO Mechlorethamine results in decreased expression of LAMC2 protein
Mechlorethamine results in increased degradation of LAMC2 protein
CTD PMID:9504665, PMID:18095945 NCBI chr13:70,566,643...70,632,126
Ensembl chr13:70,566,643...70,626,252
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO Mechlorethamine results in increased phosphorylation of MAPK1 protein
Mechlorethamine results in increased phosphorylation of and affects the localization of MAPK1 protein
CTD PMID:25891025, PMID:31639410 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO Mechlorethamine results in increased phosphorylation of MAPK3 protein
Mechlorethamine results in increased phosphorylation of and affects the localization of MAPK3 protein
CTD PMID:25891025, PMID:31639410 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO Mechlorethamine results in increased phosphorylation of MAPK8 protein CTD PMID:25891025 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO Mechlorethamine results in increased phosphorylation of MAPK9 protein CTD PMID:25891025 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mmp10 matrix metallopeptidase 10 increases expression EXP Mechlorethamine results in increased expression of MMP10 mRNA CTD PMID:26273949 NCBI chr 8:5,734,348...5,742,243
Ensembl chr 8:5,734,348...5,742,243
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
multiple interactions
ISO
EXP
Mechlorethamine results in increased expression of MMP9; Mechlorethamine results in increased expression of MMP9 protein
Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of MMP9 mRNA]
Mechlorethamine results in increased expression of MMP9 mRNA; Mechlorethamine results in increased expression of MMP9 protein
MPO gene mutant form inhibits the reaction [Mechlorethamine results in increased expression of MMP9]; SFTPD gene mutant form promotes the reaction [Mechlorethamine results in increased expression of MMP9 protein]
CTD PMID:20883710, PMID:24631667, PMID:25891025, PMID:26273949, PMID:28184907, PMID:30060251 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mobp myelin-associated oligodendrocyte basic protein decreases expression ISO Mechlorethamine results in decreased expression of MOBP mRNA CTD PMID:17107856 NCBI chr 8:128,824,420...128,854,492
Ensembl chr 8:128,824,508...128,850,358
JBrowse link
G Mpo myeloperoxidase multiple interactions
increases response to substance
ISO MPO gene mutant form inhibits the reaction [Mechlorethamine results in increased expression of MMP9]; MPO gene mutant form inhibits the reaction [Mechlorethamine results in increased expression of NOS2]; MPO gene mutant form inhibits the reaction [Mechlorethamine results in increased expression of PTGS2]
MPO protein results in increased susceptibility to Mechlorethamine
CTD PMID:24631667 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mrc1 mannose receptor, C type 1 increases expression
multiple interactions
EXP
ISO
Mechlorethamine results in increased expression of MRC1 protein
SFTPD gene mutant form promotes the reaction [Mechlorethamine results in increased expression of MRC1 protein]
CTD PMID:26273949, PMID:30060251 NCBI chr17:81,352,700...81,433,743
Ensembl chr17:81,352,700...81,433,743
JBrowse link
G Msh2 mutS homolog 2 affects response to substance ISO MSH2 protein affects the susceptibility to Mechlorethamine CTD PMID:12185594 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932
JBrowse link
G Nckap1 NCK-associated protein 1 decreases expression ISO Mechlorethamine results in decreased expression of NCKAP1 mRNA CTD PMID:17107856 NCBI chr 3:67,725,180...67,804,680
Ensembl chr 3:67,725,947...67,787,990
JBrowse link
G Ndrg2 NDRG family member 2 decreases expression ISO Mechlorethamine results in decreased expression of NDRG2 mRNA CTD PMID:17107856 NCBI chr15:28,305,820...28,314,459
Ensembl chr15:28,305,821...28,314,459
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects response to substance
decreases response to substance
ISO NFE2L2 gene mutant form affects the susceptibility to Mechlorethamine
NFE2L2 protein results in decreased susceptibility to Mechlorethamine
CTD PMID:20932822, PMID:26454883 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nmu neuromedin U increases expression ISO Mechlorethamine results in increased expression of NMU mRNA CTD PMID:17107856 NCBI chr14:34,353,683...34,381,968
Ensembl chr14:34,354,503...34,381,828
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
ISO
EXP
Mechlorethamine results in increased expression of NOS2; Mechlorethamine results in increased expression of NOS2 protein
Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of NOS2 mRNA]
Mechlorethamine results in increased expression of NOS2 mRNA; Mechlorethamine results in increased expression of NOS2 protein
MPO gene mutant form inhibits the reaction [Mechlorethamine results in increased expression of NOS2]; SFTPD gene mutant form promotes the reaction [Mechlorethamine results in increased expression of NOS2 protein]
CTD PMID:20883710, PMID:24631667, PMID:25891025, PMID:26273949, PMID:28184907, PMID:30060251 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression
multiple interactions
EXP Mechlorethamine results in increased expression of PCNA; Mechlorethamine results in increased expression of PCNA protein
Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of PCNA protein]
CTD PMID:22981630, PMID:28184907 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pdcd4 programmed cell death 4 increases expression ISO Mechlorethamine results in increased expression of PDCD4 mRNA CTD PMID:17107856 NCBI chr 1:274,616,625...274,648,204
Ensembl chr 1:274,625,224...274,648,204
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 increases expression ISO Mechlorethamine results in increased expression of PDPK1 protein modified form CTD PMID:25891025 NCBI chr10:13,446,373...13,525,248
Ensembl chr10:13,451,624...13,515,448
JBrowse link
G Plp1 proteolipid protein 1 decreases expression ISO Mechlorethamine results in decreased expression of PLP1 mRNA CTD PMID:17107856 NCBI chr  X:107,494,326...107,511,355
Ensembl chr  X:107,496,072...107,511,348
JBrowse link
G Polr2j RNA polymerase II subunit J decreases expression ISO Mechlorethamine results in decreased expression of POLR2J mRNA CTD PMID:17107856 NCBI chr12:23,587,222...23,592,774
Ensembl chr12:23,587,222...23,592,774
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO Mechlorethamine results in increased expression of PPARA protein CTD PMID:27125198 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Psmd11 proteasome 26S subunit, non-ATPase 11 increases expression ISO Mechlorethamine results in increased expression of PSMD11 mRNA CTD PMID:17107856 NCBI chr10:67,810,655...67,857,562
Ensembl chr10:67,810,655...67,857,223
JBrowse link
G Psmd7 proteasome 26S subunit, non-ATPase 7 increases expression ISO Mechlorethamine results in increased expression of PSMD7 mRNA CTD PMID:17107856 NCBI chr19:39,639,432...39,646,718
Ensembl chr19:39,639,431...39,646,693
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO
EXP
Mechlorethamine results in increased expression of PTGS2; Mechlorethamine results in increased expression of PTGS2 protein
Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of PTGS2 mRNA]
MPO gene mutant form inhibits the reaction [Mechlorethamine results in increased expression of PTGS2]
Mechlorethamine results in increased expression of PTGS2 mRNA; Mechlorethamine results in increased expression of PTGS2 protein
CTD PMID:20883710, PMID:24631667, PMID:25891025, PMID:26273949, PMID:28184907 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rad51 RAD51 recombinase increases expression ISO Mechlorethamine results in increased expression of RAD51 protein CTD PMID:25891025 NCBI chr 3:110,918,240...110,942,920
Ensembl chr 3:110,918,243...110,942,917
JBrowse link
G Sem1 SEM1, 26S proteasome complex subunit increases expression ISO Mechlorethamine results in increased expression of SEM1 mRNA CTD PMID:17107856 NCBI chr 4:32,067,444...32,087,600
Ensembl chr 4:32,067,444...32,087,600
JBrowse link
G Sftpd surfactant protein D increases expression
increases response to substance
multiple interactions
ISO Mechlorethamine results in increased expression of SFTPD protein
SFTPD gene mutant form results in increased susceptibility to Mechlorethamine
SFTPD gene mutant form promotes the reaction [Mechlorethamine results in increased expression of CHIL3 protein]; SFTPD gene mutant form promotes the reaction [Mechlorethamine results in increased expression of HMOX1 protein]; SFTPD gene mutant form promotes the reaction [Mechlorethamine results in increased expression of MMP9 protein]; SFTPD gene mutant form promotes the reaction [Mechlorethamine results in increased expression of MRC1 protein]; SFTPD gene mutant form promotes the reaction [Mechlorethamine results in increased expression of NOS2 protein]
CTD PMID:30060251 NCBI chr16:18,753,535...18,766,100
Ensembl chr16:18,745,458...18,766,174
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Mechlorethamine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions
EXP Mechlorethamine results in increased expression of SOD2; Mechlorethamine results in increased expression of SOD2 protein
Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of SOD2 protein]
CTD PMID:22981630, PMID:28184907 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Stk11 serine/threonine kinase 11 increases expression ISO Mechlorethamine results in increased expression of STK11 mRNA CTD PMID:17107856 NCBI chr 7:12,440,751...12,457,513
Ensembl chr 7:12,440,751...12,457,513
JBrowse link
G Tnf tumor necrosis factor increases expression ISO
EXP
Mechlorethamine results in increased expression of TNF protein
Mechlorethamine results in increased expression of TNF mRNA; Mechlorethamine results in increased expression of TNF protein
CTD PMID:25891025, PMID:26243812, PMID:26273949 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf12a TNF receptor superfamily member 12A decreases expression ISO Mechlorethamine results in decreased expression of TNFRSF12A mRNA CTD PMID:17107856 NCBI chr10:12,995,904...12,997,930
Ensembl chr10:12,995,904...12,997,930
JBrowse link
G Tp53 tumor protein p53 multiple interactions
affects response to substance
increases expression
ISO Mechlorethamine results in increased phosphorylation of and results in increased expression of TRP53 protein
TRP53 affects the susceptibility to Mechlorethamine; TRP53 protein affects the susceptibility to Mechlorethamine
Mechlorethamine results in increased expression of TP53 protein
CTD PMID:12185594, PMID:16738803, PMID:23845566, PMID:25891025 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Txn1 thioredoxin 1 decreases activity ISO Mechlorethamine results in decreased activity of TXN protein CTD PMID:26451472 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions ISO
EXP
[NADP co-treated with Mechlorethamine] results in decreased activity of TXNRD1 protein
[NADP co-treated with Mechlorethamine] promotes the reaction [TXNRD1 protein binds to TXNRD1 protein]; [NADP co-treated with Mechlorethamine] results in decreased activity of and results in increased alkylation of TXNRD1 protein
CTD PMID:24274902 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Txnrd2 thioredoxin reductase 2 decreases activity ISO Mechlorethamine results in decreased activity of TXNRD2 protein CTD PMID:24274902 NCBI chr11:86,667,994...86,716,063
Ensembl chr11:86,667,997...86,716,254
JBrowse link
G Ube2k ubiquitin-conjugating enzyme E2K increases expression ISO Mechlorethamine results in increased expression of UBE2K mRNA CTD PMID:17107856 NCBI chr14:44,289,247...44,348,691
Ensembl chr14:44,289,247...44,348,691
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        aetiopathogenetic role 18937
          genotoxin 16961
            mutagen 16777
              alkylating agent 13402
                mechlorethamine 88
                  mechlorethamine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            heteroorganic entity 19148
                              organohalogen compound 17712
                                organochlorine compound 17466
                                  mechlorethamine 88
                                    mechlorethamine hydrochloride 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.