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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:mechlorethamine
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Accession:CHEBI:28925 term browser browse the term
Definition:A nitrogen mustard that has formula C5H11Cl2N.
Synonyms:exact_synonym: 2-chloro-N-(2-chloroethyl)-N-methylethanamine
 related_synonym: 2,2'-dichloro-N-methyldiethylamine;   Formula=C5H11Cl2N;   InChI=1S/C5H11Cl2N/c1-8(4-2-6)5-3-7/h2-5H2,1H3;   InChIKey=HAWPXGHAZFHHAD-UHFFFAOYSA-N;   N-methyl-bis(2-chloroethyl)amine;   N-methyl-bis(beta-chloroethyl)amine;   SMILES=CN(CCCl)CCCl;   beta,beta'-dichlorodiethyl-N-methylamine;   bis(2-chloroethyl)methylamine;   bis(beta-chloroethyl)methylamine;   chlormethine;   methylbis(2-chloroethyl)amine;   methylbis(beta-chloroethyl)amine;   nitrogen mustard
 alt_id: CHEBI:25557;   CHEBI:6708
 xref: CAS:51-75-2;   DrugBank:DB00888;   Drug_Central:1647;   KEGG:C07115;   KEGG:D07671
 xref_mesh: MESH:D008466
 xref: Wikipedia:Mechlorethamine


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mechlorethamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a multiple interactions
increases expression		 EXP Valproic Acid promotes the reaction [Mechlorethamine results in increased expression of AGTR1A mRNA] CTD PMID:28184907 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression ISO Mechlorethamine results in increased expression of AIFM1 mRNA CTD PMID:17107856 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Ampd3 adenosine monophosphate deaminase 3 increases expression ISO Mechlorethamine results in increased expression of AMPD3 mRNA CTD PMID:17107856 NCBI chr 1:164,884,823...164,929,899
Ensembl chr 1:164,885,320...164,929,887 		JBrowse link
G Apcs amyloid P component, serum increases expression EXP Mechlorethamine results in increased expression of APCS mRNA CTD PMID:26273949 NCBI chr13:85,373,219...85,374,195
Ensembl chr13:85,373,220...85,374,298 		JBrowse link
G Apoe apolipoprotein E multiple interactions
increases expression		 EXP Valproic Acid promotes the reaction [Mechlorethamine results in increased expression of APOE mRNA] CTD PMID:26273949 PMID:28184907 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Arl11 ADP-ribosylation factor like GTPase 11 multiple interactions
increases expression		 ISO NR1H4 protein affects the reaction [Mechlorethamine results in increased expression of ARL11 protein] CTD PMID:35998709 NCBI chr15:35,483,330...35,485,579
Ensembl chr15:35,480,018...35,496,596 		JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 decreases expression ISO Mechlorethamine results in decreased expression of ATP1A2 mRNA CTD PMID:17107856 NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO Mechlorethamine results in increased expression of BAK1 protein CTD PMID:22285227 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Mechlorethamine results in increased expression of and results in decreased localization of BAX protein; Mechlorethamine results in increased expression of and results in increased activity of BAX protein CTD PMID:16738803 PMID:22285227 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Mechlorethamine results in decreased expression of BCL2 protein CTD PMID:16738803 PMID:22285227 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Calm3 calmodulin 3 decreases expression ISO Mechlorethamine results in decreased expression of CALM3 mRNA CTD PMID:17107856 NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207 		JBrowse link
G Casp2 caspase 2 increases activity ISO Mechlorethamine results in increased activity of CASP2 protein CTD PMID:16738803 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 ISO Mechlorethamine results in increased activity of CASP3 protein
ebselen inhibits the reaction [Mechlorethamine results in increased activity of CASP3 protein]		 CTD PMID:23649643 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions		 ISO Mechlorethamine results in increased activity of CASP9 protein
ebselen inhibits the reaction [Mechlorethamine results in increased activity of CASP9 protein]; Mechlorethamine results in increased cleavage of and results in increased activity of CASP9 protein		 CTD PMID:16738803 PMID:22285227 PMID:23649643 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression EXP Mechlorethamine results in increased expression of CCL2 mRNA CTD PMID:26273949 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression EXP Mechlorethamine results in increased expression of CCL5 mRNA CTD PMID:26273949 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccn2 cellular communication network factor 2 increases expression EXP Mechlorethamine results in increased expression of CCN2 mRNA; Mechlorethamine results in increased expression of CCN2 protein CTD PMID:20883710 PMID:26273949 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccna2 cyclin A2 multiple interactions
increases stability		 ISO Mechlorethamine results in decreased activity of [CCNA2 protein binds to CDK2 protein]; Mechlorethamine results in increased expression of and results in increased activity of [CDK2 protein binds to CCNA2 protein]; Pentoxifylline inhibits the reaction [Mechlorethamine results in increased activity of [CCNA2 protein binds to CDK2 protein]]
Mechlorethamine results in increased stability of CCNA2 protein		 CTD PMID:8463339 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 decreases activity
multiple interactions		 ISO Mechlorethamine results in decreased activity of CCNB1 protein
Mechlorethamine results in decreased activity of [CCNB1 protein binds to CDK1 protein]; Pentoxifylline inhibits the reaction [Mechlorethamine results in decreased activity of [CCNB1 protein binds to CDK1 protein]]		 CTD PMID:8463339 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 multiple interactions
increases expression		 EXP Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of CCR2 mRNA]
Mechlorethamine results in increased expression of CCR2 mRNA; Mechlorethamine results in increased expression of CCR2 protein		 CTD PMID:26273949 PMID:28184907 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 increases expression EXP Mechlorethamine results in increased expression of CCR5 mRNA CTD PMID:26273949 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260 		JBrowse link
G Cd163 CD163 molecule increases expression
multiple interactions		 EXP
ISO		 Mechlorethamine results in increased expression of CD163 protein
NR1H4 protein affects the reaction [Mechlorethamine results in increased expression of CD163 protein]		 CTD PMID:26273949 PMID:35998709 NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878 		JBrowse link
G Cd68 Cd68 molecule increases expression EXP Mechlorethamine results in increased expression of CD68 protein CTD PMID:26273949 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions
decreases activity
increases stability		 ISO Mechlorethamine results in decreased activity of [CCNB1 protein binds to CDK1 protein]; Pentoxifylline inhibits the reaction [Mechlorethamine results in decreased activity of [CCNB1 protein binds to CDK1 protein]]
Mechlorethamine results in decreased activity of CDK1 protein
Mechlorethamine results in increased stability of CDK1 protein modified form		 CTD PMID:8463339 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk2 cyclin dependent kinase 2 increases activity
multiple interactions		 ISO Mechlorethamine results in increased activity of CDK2 protein
Mechlorethamine results in decreased activity of [CCNA2 protein binds to CDK2 protein]; Mechlorethamine results in increased expression of and results in increased activity of [CDK2 protein binds to CCNA2 protein]; Pentoxifylline inhibits the reaction [Mechlorethamine results in increased activity of [CCNA2 protein binds to CDK2 protein]]		 CTD PMID:8463339 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cnr1 cannabinoid receptor 1 increases expression ISO Mechlorethamine results in increased expression of CNR1 protein CTD PMID:27125198 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Cnr2 cannabinoid receptor 2 increases expression ISO Mechlorethamine results in increased expression of CNR2 protein CTD PMID:27125198 NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 increases expression EXP Mechlorethamine results in increased expression of CX3CL1 mRNA CTD PMID:26273949 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 increases expression
multiple interactions		 EXP Mechlorethamine results in increased expression of CX3CR1 mRNA; Mechlorethamine results in increased expression of CX3CR1 protein
Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of CX3CR1 mRNA]		 CTD PMID:26273949 PMID:28184907 NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 affects response to substance ISO CXCR2 protein affects the susceptibility to Mechlorethamine CTD PMID:12753603 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO Mechlorethamine results in increased expression of CXCR4 mRNA CTD PMID:17107856 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO [Mechlorethamine co-treated with Dimethyl Sulfoxide] results in increased phosphorylation of EIF4EBP1 protein; Mechlorethamine inhibits the reaction [Dimethyl Sulfoxide results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:36708981 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Ep300 E1A binding protein p300 increases expression EXP Mechlorethamine results in increased expression of EP300 protein CTD PMID:33971176 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 decreases expression ISO Mechlorethamine results in decreased expression of ERBB2 protein CTD PMID:17932452 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Faah fatty acid amide hydrolase increases expression ISO Mechlorethamine results in increased expression of FAAH protein CTD PMID:27125198 NCBI chr 5:129,479,774...129,499,018
Ensembl chr 5:129,479,824...129,498,677 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Mechlorethamine results in increased expression of and affects the localization of FOS protein; Mechlorethamine results in increased phosphorylation of and results in increased expression of FOS protein
FOS protein affects the reaction [Mechlorethamine results in increased secretion of CXCL8 protein]		 CTD PMID:25891025 PMID:31639410 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO FOSB protein affects the reaction [Mechlorethamine results in increased secretion of CXCL8 protein]; FOSL1 protein affects the reaction [Mechlorethamine results in increased expression of and affects the localization of FOSB protein]; Mechlorethamine results in increased expression of and affects the localization of FOSB protein; U 0126 inhibits the reaction [Mechlorethamine results in increased expression of FOSB protein] CTD PMID:31639410 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression
multiple interactions		 ISO Mechlorethamine results in increased expression of FOSL1 protein
FOSL1 protein affects the reaction [Mechlorethamine results in increased expression of and affects the localization of FOSB protein]; FOSL1 protein affects the reaction [Mechlorethamine results in increased expression of CXCL8 mRNA]; FOSL1 protein affects the reaction [Mechlorethamine results in increased secretion of CXCL8 protein]; Mechlorethamine promotes the reaction [FOSL1 protein binds to JUN protein]; Mechlorethamine promotes the reaction [FOSL1 protein binds to JUNB protein]; Mechlorethamine promotes the reaction [FOSL1 protein binds to JUND protein]; Mechlorethamine results in increased expression of and affects the localization of FOSL1 protein; U 0126 inhibits the reaction [Mechlorethamine results in increased expression of FOSL1 protein]		 CTD PMID:31639410 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930 		JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit increases expression
multiple interactions		 ISO Mechlorethamine results in increased expression of FOSL2 protein
FOSL2 protein affects the reaction [Mechlorethamine results in increased secretion of CXCL8 protein]		 CTD PMID:31639410 NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034 		JBrowse link
G Gdf9 growth differentiation factor 9 increases expression ISO Mechlorethamine results in increased expression of GDF9 mRNA CTD PMID:17107856 NCBI chr10:37,589,200...37,599,970
Ensembl chr10:37,595,679...37,599,672 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 decreases response to substance
increases expression		 ISO GSTA2 protein results in decreased susceptibility to Mechlorethamine
Mechlorethamine results in increased expression of GSTA2 mRNA		 CTD PMID:15778998 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798 		JBrowse link
G Gsta3 glutathione S-transferase alpha 3 decreases response to substance EXP GSTA3 protein results in decreased susceptibility to Mechlorethamine CTD PMID:8044793 PMID:8860835 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO
EXP		 Mechlorethamine results in increased expression of H2AX protein modified form CTD PMID:25891025 PMID:33971176 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hdac2 histone deacetylase 2 multiple interactions
increases expression		 EXP Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of HDAC2 protein] CTD PMID:28184907 PMID:33971176 NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 EXP
ISO		 Mechlorethamine results in increased expression of HMOX1; Mechlorethamine results in increased expression of HMOX1 protein
Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of HMOX1 protein]
NR1H4 protein affects the reaction [Mechlorethamine results in increased expression of HMOX1]; SFTPD gene mutant form promotes the reaction [Mechlorethamine results in increased expression of HMOX1 protein]		 CTD PMID:22981630 PMID:28184907 PMID:30060251 PMID:35998709 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il10 interleukin 10 increases expression
multiple interactions		 EXP Mechlorethamine results in increased expression of IL10 mRNA
Valproic Acid promotes the reaction [Mechlorethamine results in increased expression of IL10 mRNA]		 CTD PMID:26273949 PMID:28184907 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12a interleukin 12A increases expression EXP Mechlorethamine results in increased expression of IL12A mRNA CTD PMID:26273949 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B increases expression
multiple interactions		 EXP Mechlorethamine results in increased expression of IL12B mRNA
Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of IL12B mRNA]		 CTD PMID:28184907 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 ISO KIT gene mutant form inhibits the reaction [Mechlorethamine results in increased expression of IL1B mRNA] CTD PMID:34453837 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il33 interleukin 33 multiple interactions
increases expression		 ISO KIT gene mutant form inhibits the reaction [Mechlorethamine results in increased expression of IL33 mRNA] CTD PMID:34453837 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 ISO KIT gene mutant form inhibits the reaction [Mechlorethamine results in increased expression of IL6 mRNA] CTD PMID:34453837 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgam integrin subunit alpha M increases expression EXP Mechlorethamine results in increased expression of ITGAM protein CTD PMID:26273949 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Jag1 jagged canonical Notch ligand 1 increases expression ISO Mechlorethamine results in increased expression of JAG1 mRNA CTD PMID:17107856 NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation
multiple interactions
increases expression		 ISO Mechlorethamine results in increased phosphorylation of JUN protein
Mechlorethamine promotes the reaction [FOSL1 protein binds to JUN protein]; U 0126 inhibits the reaction [Mechlorethamine results in increased expression of JUN protein]
Mechlorethamine results in increased expression of and affects the localization of JUN protein		 CTD PMID:25891025 PMID:31639410 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 ISO Mechlorethamine promotes the reaction [FOSL1 protein binds to JUNB protein]; U 0126 inhibits the reaction [Mechlorethamine results in increased expression of JUNB protein]
Mechlorethamine results in increased expression of and affects the localization of JUNB protein		 CTD PMID:31639410 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 ISO Mechlorethamine promotes the reaction [FOSL1 protein binds to JUND protein]; U 0126 inhibits the reaction [Mechlorethamine results in increased expression of JUND protein]
Mechlorethamine results in increased expression of and affects the localization of JUND protein		 CTD PMID:31639410 NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase affects response to substance
multiple interactions		 ISO KIT gene mutant form affects the susceptibility to Mechlorethamine
KIT gene mutant form inhibits the reaction [Mechlorethamine results in increased expression of IL1B mRNA]; KIT gene mutant form inhibits the reaction [Mechlorethamine results in increased expression of IL33 mRNA]; KIT gene mutant form inhibits the reaction [Mechlorethamine results in increased expression of IL6 mRNA]; KIT gene mutant form inhibits the reaction [Mechlorethamine results in increased expression of PTGS2 mRNA]; KIT gene mutant form inhibits the reaction [Mechlorethamine results in increased expression of TNF mRNA]		 CTD PMID:34453837 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652 		JBrowse link
G Lamc2 laminin subunit gamma 2 decreases expression
increases degradation		 ISO Mechlorethamine results in decreased expression of LAMC2 protein
Mechlorethamine results in increased degradation of LAMC2 protein		 CTD PMID:9504665 PMID:18095945 NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO Mechlorethamine results in increased phosphorylation of MAPK1 protein
Mechlorethamine results in increased phosphorylation of and affects the localization of MAPK1 protein		 CTD PMID:25891025 PMID:31639410 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions		 ISO Mechlorethamine results in increased phosphorylation of MAPK3 protein
Mechlorethamine results in increased phosphorylation of and affects the localization of MAPK3 protein		 CTD PMID:25891025 PMID:31639410 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO Mechlorethamine results in increased phosphorylation of MAPK8 protein CTD PMID:25891025 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO Mechlorethamine results in increased phosphorylation of MAPK9 protein CTD PMID:25891025 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mir106b microRNA 106b increases expression EXP Mechlorethamine results in increased expression of MIR106B mRNA CTD PMID:33971176 NCBI chr12:17,043,344...17,043,425
Ensembl chr12:17,043,344...17,043,425 		JBrowse link
G Mir125a microRNA 125a increases expression EXP Mechlorethamine results in increased expression of MIR125A mRNA CTD PMID:33971176 NCBI chr 1:58,677,626...58,677,710
Ensembl chr 1:58,677,626...58,677,710 		JBrowse link
G Mir125b1 microRNA 125b-1 increases expression EXP Mechlorethamine results in increased expression of MIR125B1 mRNA CTD PMID:33971176 NCBI chr 8:41,952,966...41,953,052
Ensembl chr 8:41,952,966...41,953,052 		JBrowse link
G Mir127 microRNA 127 increases expression EXP Mechlorethamine results in increased expression of MIR127 mRNA CTD PMID:33971176 NCBI chr 6:128,546,215...128,546,311
Ensembl chr 6:128,546,215...128,546,311 		JBrowse link
G Mir136 microRNA 136 increases expression EXP Mechlorethamine results in increased expression of MIR136 mRNA CTD PMID:33971176 NCBI chr 6:128,549,096...128,549,177
Ensembl chr 6:128,549,096...128,549,177 		JBrowse link
G Mir140 microRNA 140 increases expression EXP Mechlorethamine results in increased expression of MIR140 mRNA CTD PMID:33971176 NCBI chr19:35,465,577...35,465,675
Ensembl chr19:35,465,577...35,465,675 		JBrowse link
G Mir141 microRNA 141 increases expression EXP Mechlorethamine results in increased expression of MIR141 mRNA CTD PMID:33971176 NCBI chr 4:157,523,239...157,523,332
Ensembl chr 4:157,523,239...157,523,332 		JBrowse link
G Mir142 microRNA 142 increases expression EXP Mechlorethamine results in increased expression of MIR142 mRNA CTD PMID:33971176 NCBI chr10:72,557,864...72,557,950
Ensembl chr10:72,557,857...72,557,967 		JBrowse link
G Mir145 microRNA 145 increases expression EXP Mechlorethamine results in increased expression of MIR145 mRNA CTD PMID:33971176 NCBI chr18:55,099,640...55,099,727
Ensembl chr18:55,099,640...55,099,727 		JBrowse link
G Mir146a microRNA 146a multiple interactions ISO [NR1H4 protein affects the susceptibility to Mechlorethamine] which affects the expression of MIR146 mRNA CTD PMID:35998709 NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610 		JBrowse link
G Mir146b microRNA 146b decreases expression EXP Mechlorethamine results in decreased expression of MIR146B mRNA CTD PMID:33971176 NCBI chr 1:245,203,438...245,203,525
Ensembl chr 1:245,203,438...245,203,525 		JBrowse link
G Mir148b microRNA 148b increases expression EXP Mechlorethamine results in increased expression of MIR148B mRNA CTD PMID:33971176 NCBI chr 7:134,421,398...134,421,494
Ensembl chr 7:134,421,398...134,421,494 		JBrowse link
G Mir152 microRNA 152 increases expression EXP Mechlorethamine results in increased expression of MIR152 mRNA CTD PMID:33971176 NCBI chr10:81,832,936...81,833,020
Ensembl chr10:81,832,936...81,833,020 		JBrowse link
G Mir155 microRNA 155 increases expression ISO Mechlorethamine results in increased expression of MIR155 mRNA CTD PMID:35998709 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718 		JBrowse link
G Mir15b microRNA 15b increases expression EXP Mechlorethamine results in increased expression of MIR15B mRNA CTD PMID:33971176 NCBI chr 2:153,245,200...153,245,297
Ensembl chr 2:153,245,200...153,245,297 		JBrowse link
G Mir16 microRNA 16 increases expression EXP Mechlorethamine results in increased expression of MIR16 mRNA CTD PMID:33971176 NCBI chr 2:153,245,349...153,245,443
Ensembl chr 2:153,245,349...153,245,443 		JBrowse link
G Mir17 microRNA 17 increases expression EXP Mechlorethamine results in increased expression of MIR17 mRNA CTD PMID:33971176 NCBI chr15:92,180,629...92,180,712
Ensembl chr15:92,180,629...92,180,712 		JBrowse link
G Mir181a2 microRNA 181a-2 increases expression EXP Mechlorethamine results in increased expression of MIR181A2 mRNA CTD PMID:33971176 NCBI chr 3:22,615,845...22,615,961
Ensembl chr 3:22,615,845...22,615,961 		JBrowse link
G Mir181b1 microRNA 181b-1 increases expression EXP Mechlorethamine results in increased expression of MIR181B1 mRNA CTD PMID:33971176 NCBI chr13:49,485,688...49,485,797
Ensembl chr13:49,485,688...49,485,797 		JBrowse link
G Mir181c microRNA 181c increases expression EXP Mechlorethamine results in increased expression of MIR181C mRNA CTD PMID:33971176 NCBI chr19:23,983,523...23,983,628
Ensembl chr19:23,983,523...23,983,628 		JBrowse link
G Mir181d microRNA 181d increases expression EXP Mechlorethamine results in increased expression of MIR181D mRNA CTD PMID:33971176 NCBI chr19:23,983,706...23,983,788
Ensembl chr19:23,983,706...23,983,788 		JBrowse link
G Mir183 microRNA 183 increases expression EXP Mechlorethamine results in increased expression of MIR183 mRNA CTD PMID:33971176 NCBI chr 4:58,788,614...58,788,723
Ensembl chr 4:58,788,614...58,788,723 		JBrowse link
G Mir186 microRNA 186 increases expression EXP Mechlorethamine results in increased expression of MIR186 mRNA CTD PMID:33971176 NCBI chr 2:246,582,806...246,582,891
Ensembl chr 2:246,582,806...246,582,891 		JBrowse link
G Mir195 microRNA 195 increases expression EXP Mechlorethamine results in increased expression of MIR195 mRNA CTD PMID:33971176 NCBI chr10:54,951,838...54,951,924
Ensembl chr10:54,951,838...54,951,924 		JBrowse link
G Mir19a microRNA 19a increases expression EXP Mechlorethamine results in increased expression of MIR19A mRNA CTD PMID:33971176 NCBI chr15:92,180,912...92,180,993
Ensembl chr15:92,180,912...92,180,993 		JBrowse link
G Mir19b1 microRNA 19b-1 increases expression EXP Mechlorethamine results in increased expression of MIR19B1 mRNA CTD PMID:33971176 NCBI chr15:92,181,214...92,181,300
Ensembl chr15:92,181,214...92,181,300 		JBrowse link
G Mir200a microRNA 200a increases expression EXP Mechlorethamine results in increased expression of MIR200A mRNA CTD PMID:33971176 NCBI chr 5:166,648,494...166,648,582 JBrowse link
G Mir200c microRNA 200c increases expression EXP Mechlorethamine results in increased expression of MIR200C mRNA CTD PMID:33971176 NCBI chr 4:157,523,679...157,523,747 JBrowse link
G Mir205 microRNA 205 increases expression EXP Mechlorethamine results in increased expression of MIR205 mRNA CTD PMID:33971176 NCBI chr13:105,035,878...105,035,985
Ensembl chr13:105,035,878...105,035,985 		JBrowse link
G Mir20a microRNA 20a increases expression EXP Mechlorethamine results in increased expression of MIR20A mRNA CTD PMID:33971176 NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168 		JBrowse link
G Mir20b microRNA 20b increases expression EXP Mechlorethamine results in increased expression of MIR20B mRNA CTD PMID:33971176 NCBI chr  X:132,422,211...132,422,282
Ensembl chr  X:132,422,211...132,422,282 		JBrowse link
G Mir21 microRNA 21 increases expression EXP Mechlorethamine results in increased expression of MIR21 mRNA CTD PMID:33971176 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mir221 microRNA 221 increases expression EXP Mechlorethamine results in increased expression of MIR221 mRNA CTD PMID:33971176 NCBI chr  X:3,429,465...3,429,573
Ensembl chr  X:3,429,465...3,429,573 		JBrowse link
G Mir222 microRNA 222 increases expression EXP Mechlorethamine results in increased expression of MIR222 mRNA CTD PMID:33971176 NCBI chr  X:3,428,904...3,429,006
Ensembl chr  X:3,428,904...3,429,006 		JBrowse link
G Mir223 microRNA 223 multiple interactions ISO [NR1H4 protein affects the susceptibility to Mechlorethamine] which affects the expression of MIR223 mRNA CTD PMID:35998709 NCBI chr  X:61,141,887...61,141,996
Ensembl chr  X:61,141,887...61,141,996 		JBrowse link
G Mir23b microRNA 23b increases expression EXP Mechlorethamine results in increased expression of MIR23B mRNA CTD PMID:33971176 NCBI chr17:1,813,667...1,813,763
Ensembl chr17:1,813,667...1,813,763 		JBrowse link
G Mir26a microRNA 26a increases expression EXP Mechlorethamine results in increased expression of MIR26A mRNA CTD PMID:33971176 NCBI chr 8:118,755,289...118,755,378
Ensembl chr 8:118,755,289...118,755,378 		JBrowse link
G Mir27a microRNA 27a increases expression EXP Mechlorethamine results in increased expression of MIR27A mRNA CTD PMID:33971176 NCBI chr19:23,954,831...23,954,917
Ensembl chr19:23,954,831...23,954,917 		JBrowse link
G Mir27b microRNA 27b increases expression EXP Mechlorethamine results in increased expression of MIR27B mRNA CTD PMID:33971176 NCBI chr17:1,813,427...1,813,523
Ensembl chr17:1,813,426...1,813,529 		JBrowse link
G Mir29a microRNA 29a increases expression EXP Mechlorethamine results in increased expression of MIR29A mRNA CTD PMID:33971176 NCBI chr 4:59,650,608...59,650,695 JBrowse link
G Mir30a microRNA 30a increases expression EXP Mechlorethamine results in increased expression of MIR30A mRNA CTD PMID:33971176 NCBI chr 9:25,737,600...25,737,670
Ensembl chr 9:25,737,600...25,737,670 		JBrowse link
G Mir30b microRNA 30b increases expression EXP Mechlorethamine results in increased expression of MIR30B mRNA CTD PMID:33971176 NCBI chr 7:100,132,589...100,132,675
Ensembl chr 7:100,132,589...100,132,675 		JBrowse link
G Mir30c1 microRNA 30c-1 increases expression EXP Mechlorethamine results in increased expression of MIR30C1 mRNA CTD PMID:33971176 NCBI chr 5:134,349,237...134,349,325
Ensembl chr 5:134,349,237...134,349,325 		JBrowse link
G Mir30d microRNA 30d increases expression EXP Mechlorethamine results in increased expression of MIR30D mRNA CTD PMID:33971176 NCBI chr 7:100,136,391...100,136,472
Ensembl chr 7:100,136,391...100,136,472 		JBrowse link
G Mir30e microRNA 30e increases expression EXP Mechlorethamine results in increased expression of MIR30E mRNA CTD PMID:33971176 NCBI chr 5:134,352,232...134,352,323
Ensembl chr 5:134,352,232...134,352,323 		JBrowse link
G Mir320a microRNA 320a increases expression EXP Mechlorethamine results in increased expression of MIR320A mRNA CTD PMID:33971176 NCBI chr15:45,516,392...45,516,473
Ensembl chr15:45,516,392...45,516,473 		JBrowse link
G Mir322 microRNA 322 increases expression EXP Mechlorethamine results in increased expression of MIR322 mRNA CTD PMID:33971176 NCBI chr  X:132,806,594...132,806,688
Ensembl chr  X:132,806,594...132,806,688 		JBrowse link
G Mir34c microRNA 34c increases expression EXP Mechlorethamine results in increased expression of MIR34C mRNA CTD PMID:33971176 NCBI chr 8:51,409,726...51,409,802
Ensembl chr 8:51,409,726...51,409,802 		JBrowse link
G Mir3545 microRNA 3545 increases expression EXP Mechlorethamine results in increased expression of MIR203 mRNA CTD PMID:33971176 NCBI chr 6:131,199,542...131,199,656
Ensembl chr 6:131,199,542...131,199,656 		JBrowse link
G Mir374b microRNA 374b increases expression EXP Mechlorethamine results in increased expression of MIR374B mRNA CTD PMID:33971176 NCBI chr  X:68,591,732...68,591,799
Ensembl chr  X:68,591,732...68,591,799 		JBrowse link
G Mir381 microRNA 381 increases expression EXP Mechlorethamine results in increased expression of MIR381 mRNA CTD PMID:33971176 NCBI chr 6:128,740,976...128,741,036 JBrowse link
G Mir410 microRNA 410 increases expression EXP Mechlorethamine results in increased expression of MIR410 mRNA CTD PMID:33971176 NCBI chr 6:128,758,358...128,758,433
Ensembl chr 6:128,758,354...128,758,434 		JBrowse link
G Mir429 microRNA 429 increases expression EXP Mechlorethamine results in increased expression of MIR429 mRNA CTD PMID:33971176 NCBI chr 5:166,647,459...166,647,543
Ensembl chr 5:166,647,459...166,647,543 		JBrowse link
G Mir449a microRNA 449a increases expression EXP Mechlorethamine results in increased expression of MIR449A mRNA CTD PMID:33971176 NCBI chr 2:44,670,714...44,670,804
Ensembl chr 2:44,670,714...44,670,804 		JBrowse link
G Mir497 microRNA 497 increases expression EXP Mechlorethamine results in increased expression of MIR497 mRNA CTD PMID:33971176 NCBI chr10:54,951,514...54,951,582
Ensembl chr10:54,951,505...54,951,584 		JBrowse link
G Mir93 microRNA 93 increases expression EXP Mechlorethamine results in increased expression of MIR93 mRNA CTD PMID:33971176 NCBI chr12:17,043,135...17,043,221
Ensembl chr12:17,043,135...17,043,221 		JBrowse link
G Mir98 microRNA 98 increases expression EXP Mechlorethamine results in increased expression of MIR98 mRNA CTD PMID:33971176 NCBI chr  X:20,981,235...20,981,342
Ensembl chr  X:20,981,235...20,981,342 		JBrowse link
G Mirlet7b microRNA let-7b increases expression EXP Mechlorethamine results in increased expression of MIRLET7B mRNA CTD PMID:33971176 NCBI chr 7:116,804,186...116,804,270
Ensembl chr 7:116,804,186...116,804,270 		JBrowse link
G Mirlet7c1 microRNA let-7c-1 increases expression EXP Mechlorethamine results in increased expression of MIRLET7C1 mRNA CTD PMID:33971176 NCBI chr11:16,201,163...16,201,256
Ensembl chr11:16,201,158...16,201,265 		JBrowse link
G Mirlet7i microRNA let-7i increases expression EXP Mechlorethamine results in increased expression of MIRLET7I mRNA CTD PMID:33971176 NCBI chr 7:58,642,485...58,642,569
Ensembl chr 7:58,642,480...58,642,571 		JBrowse link
G Mmp10 matrix metallopeptidase 10 increases expression EXP Mechlorethamine results in increased expression of MMP10 mRNA CTD PMID:26273949 NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
multiple interactions		 ISO
EXP		 Mechlorethamine results in increased expression of MMP9; Mechlorethamine results in increased expression of MMP9 protein
MPO gene mutant form inhibits the reaction [Mechlorethamine results in increased expression of MMP9]; SFTPD gene mutant form promotes the reaction [Mechlorethamine results in increased expression of MMP9 protein]
Mechlorethamine results in increased expression of MMP9 mRNA; Mechlorethamine results in increased expression of MMP9 protein
Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of MMP9 mRNA]		 CTD PMID:20883710 PMID:24631667 PMID:25891025 PMID:26273949 PMID:28184907 More... NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mobp myelin-associated oligodendrocyte basic protein decreases expression ISO Mechlorethamine results in decreased expression of MOBP mRNA CTD PMID:17107856 NCBI chr 8:119,869,504...119,899,605
Ensembl chr 8:119,869,626...119,899,563 		JBrowse link
G Mpo myeloperoxidase multiple interactions
increases response to substance		 ISO MPO gene mutant form inhibits the reaction [Mechlorethamine results in increased expression of MMP9]; MPO gene mutant form inhibits the reaction [Mechlorethamine results in increased expression of NOS2]; MPO gene mutant form inhibits the reaction [Mechlorethamine results in increased expression of PTGS2]
MPO protein results in increased susceptibility to Mechlorethamine		 CTD PMID:24631667 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mrc1 mannose receptor, C type 1 increases expression
multiple interactions		 EXP
ISO		 Mechlorethamine results in increased expression of MRC1 protein
SFTPD gene mutant form promotes the reaction [Mechlorethamine results in increased expression of MRC1 protein]		 CTD PMID:26273949 PMID:30060251 NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857 		JBrowse link
G Msh2 mutS homolog 2 affects response to substance ISO MSH2 protein affects the susceptibility to Mechlorethamine CTD PMID:12185594 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Nckap1 NCK-associated protein 1 decreases expression ISO Mechlorethamine results in decreased expression of NCKAP1 mRNA CTD PMID:17107856 NCBI chr 3:65,417,450...65,491,769
Ensembl chr 3:65,417,453...65,492,217 		JBrowse link
G Ndrg2 NDRG family member 2 decreases expression ISO Mechlorethamine results in decreased expression of NDRG2 mRNA CTD PMID:17107856 NCBI chr15:24,600,981...24,609,621
Ensembl chr15:24,600,982...24,609,626 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects response to substance
decreases response to substance		 ISO NFE2L2 gene mutant form affects the susceptibility to Mechlorethamine
NFE2L2 protein results in decreased susceptibility to Mechlorethamine		 CTD PMID:20932822 PMID:26454883 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nmu neuromedin U increases expression ISO Mechlorethamine results in increased expression of NMU mRNA CTD PMID:17107856 NCBI chr14:31,844,564...31,872,196
Ensembl chr14:31,844,728...31,872,192 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions		 ISO
EXP		 Mechlorethamine results in increased expression of NOS2; Mechlorethamine results in increased expression of NOS2 protein
MPO gene mutant form inhibits the reaction [Mechlorethamine results in increased expression of NOS2]; SFTPD gene mutant form promotes the reaction [Mechlorethamine results in increased expression of NOS2 protein]
Mechlorethamine results in increased expression of NOS2 mRNA; Mechlorethamine results in increased expression of NOS2 protein
Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of NOS2 mRNA]		 CTD PMID:20883710 PMID:24631667 PMID:25891025 PMID:26273949 PMID:28184907 More... NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
affects response to substance		 ISO [NR1H4 protein affects the susceptibility to Mechlorethamine] which affects the expression of MIR146 mRNA; [NR1H4 protein affects the susceptibility to Mechlorethamine] which affects the expression of MIR223 mRNA; NR1H4 protein affects the reaction [Mechlorethamine results in increased expression of ARL11 protein]; NR1H4 protein affects the reaction [Mechlorethamine results in increased expression of CD163 protein]; NR1H4 protein affects the reaction [Mechlorethamine results in increased expression of HMOX1]; NR1H4 protein affects the reaction [Mechlorethamine results in increased expression of PTGS2 protein]; NR1H4 protein affects the reaction [Mechlorethamine results in increased expression of STAT6 protein] CTD PMID:35998709 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression
multiple interactions		 EXP Mechlorethamine results in increased expression of PCNA; Mechlorethamine results in increased expression of PCNA protein
Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of PCNA protein]		 CTD PMID:22981630 PMID:28184907 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pdcd4 programmed cell death 4 increases expression ISO Mechlorethamine results in increased expression of PDCD4 mRNA CTD PMID:17107856 NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 increases expression ISO Mechlorethamine results in increased expression of PDPK1 protein modified form CTD PMID:25891025 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623 		JBrowse link
G Plp1 proteolipid protein 1 decreases expression ISO Mechlorethamine results in decreased expression of PLP1 mRNA CTD PMID:17107856 NCBI chr  X:100,184,039...100,201,035
Ensembl chr  X:100,185,767...100,201,032 		JBrowse link
G Polr2j RNA polymerase II subunit J decreases expression ISO Mechlorethamine results in decreased expression of POLR2J mRNA CTD PMID:17107856 NCBI chr12:20,543,038...20,548,590
Ensembl chr12:20,543,038...20,548,594 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO Mechlorethamine results in increased expression of PPARA protein CTD PMID:27125198 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Psmd11 proteasome 26S subunit, non-ATPase 11 increases expression ISO Mechlorethamine results in increased expression of PSMD11 mRNA CTD PMID:17107856 NCBI chr10:65,433,853...65,479,774
Ensembl chr10:65,433,853...65,479,766 		JBrowse link
G Psmd7 proteasome 26S subunit, non-ATPase 7 increases expression ISO Mechlorethamine results in increased expression of PSMD7 mRNA CTD PMID:17107856 NCBI chr19:35,494,317...35,501,605
Ensembl chr19:35,494,316...35,501,588 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 ISO
EXP		 Mechlorethamine results in increased expression of PTGS2; Mechlorethamine results in increased expression of PTGS2 mRNA; Mechlorethamine results in increased expression of PTGS2 protein
KIT gene mutant form inhibits the reaction [Mechlorethamine results in increased expression of PTGS2 mRNA]; MPO gene mutant form inhibits the reaction [Mechlorethamine results in increased expression of PTGS2]; NR1H4 protein affects the reaction [Mechlorethamine results in increased expression of PTGS2 protein]
Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of PTGS2 mRNA]		 CTD PMID:20883710 PMID:24631667 PMID:25891025 PMID:26273949 PMID:28184907 More... NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rad51 RAD51 recombinase increases expression ISO Mechlorethamine results in increased expression of RAD51 protein CTD PMID:25891025 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G Rps6 ribosomal protein S6 multiple interactions ISO Mechlorethamine affects the reaction [Dimethyl Sulfoxide affects the phosphorylation of RPS6 protein]
[Dimethyl Sulfoxide co-treated with Mechlorethamine] results in increased phosphorylation of RPS6 protein; Mechlorethamine inhibits the reaction [Dimethyl Sulfoxide results in increased phosphorylation of RPS6 protein]		 CTD PMID:36708981 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 increases expression ISO Mechlorethamine results in increased expression of RPTOR protein CTD PMID:36708981 NCBI chr10:104,878,487...105,176,986
Ensembl chr10:104,878,487...105,176,983 		JBrowse link
G Sem1 SEM1 26S proteasome subunit increases expression ISO Mechlorethamine results in increased expression of SEM1 mRNA CTD PMID:17107856 NCBI chr 4:34,671,848...34,692,005
Ensembl chr 4:34,671,848...34,692,005 		JBrowse link
G Sftpd surfactant protein D increases expression
multiple interactions
increases response to substance		 ISO Mechlorethamine results in increased expression of SFTPD protein
SFTPD gene mutant form promotes the reaction [Mechlorethamine results in increased expression of CHIL3 protein]; SFTPD gene mutant form promotes the reaction [Mechlorethamine results in increased expression of HMOX1 protein]; SFTPD gene mutant form promotes the reaction [Mechlorethamine results in increased expression of MMP9 protein]; SFTPD gene mutant form promotes the reaction [Mechlorethamine results in increased expression of MRC1 protein]; SFTPD gene mutant form promotes the reaction [Mechlorethamine results in increased expression of NOS2 protein]
SFTPD gene mutant form results in increased susceptibility to Mechlorethamine		 CTD PMID:30060251 NCBI chr16:17,046,491...17,058,968
Ensembl chr16:17,046,483...17,059,927 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Mechlorethamine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Snora36c small nucleolar RNA, H/ACA box 36C increases expression EXP Mechlorethamine results in increased expression of SNORA36C mRNA CTD PMID:33971176 NCBI chr18:45,952,021...45,952,079
Ensembl chr18:45,952,021...45,952,079 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions		 EXP Mechlorethamine results in increased expression of SOD2; Mechlorethamine results in increased expression of SOD2 protein
Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of SOD2 protein]		 CTD PMID:22981630 PMID:28184907 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions
increases expression		 ISO NR1H4 protein affects the reaction [Mechlorethamine results in increased expression of STAT6 protein] CTD PMID:35998709 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495 		JBrowse link
G Stk11 serine/threonine kinase 11 increases expression ISO Mechlorethamine results in increased expression of STK11 mRNA CTD PMID:17107856 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 ISO
EXP		 Mechlorethamine results in increased expression of TNF mRNA; Mechlorethamine results in increased expression of TNF protein
KIT gene mutant form inhibits the reaction [Mechlorethamine results in increased expression of TNF mRNA]		 CTD PMID:25891025 PMID:26243812 PMID:26273949 PMID:34453837 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf12a TNF receptor superfamily member 12A decreases expression ISO Mechlorethamine results in decreased expression of TNFRSF12A mRNA CTD PMID:17107856 NCBI chr10:12,707,077...12,709,071
Ensembl chr10:12,689,890...12,709,045 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
affects response to substance
increases alkylation
increases stability
decreases activity
affects binding		 ISO Mechlorethamine results in increased phosphorylation of and results in increased expression of TRP53 protein
Mechlorethamine results in increased expression of TP53 protein
TRP53 affects the susceptibility to Mechlorethamine; TRP53 protein affects the susceptibility to Mechlorethamine
Mechlorethamine results in increased alkylation of TP53 protein
Mechlorethamine results in increased stability of TP53 protein
Mechlorethamine results in decreased activity of TP53 protein
Mechlorethamine results in increased expression of and affects the localization of TP53 protein; Mechlorethamine results in increased phosphorylation of and results in increased acetylation of TP53 protein
Mechlorethamine binds to TP53 protein		 CTD PMID:12185594 PMID:16738803 PMID:23845566 PMID:25891025 PMID:35312310 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases response to substance ISO TRPA1 protein results in increased susceptibility to Mechlorethamine CTD PMID:36693442 NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
G Txn1 thioredoxin 1 decreases activity ISO Mechlorethamine results in decreased activity of TXN protein CTD PMID:26451472 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions ISO
EXP		 [NADP co-treated with Mechlorethamine] results in decreased activity of TXNRD1 protein
[NADP co-treated with Mechlorethamine] promotes the reaction [TXNRD1 protein binds to TXNRD1 protein]; [NADP co-treated with Mechlorethamine] results in decreased activity of and results in increased alkylation of TXNRD1 protein		 CTD PMID:24274902 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Txnrd2 thioredoxin reductase 2 decreases activity ISO Mechlorethamine results in decreased activity of TXNRD2 protein CTD PMID:24274902 NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156 		JBrowse link
G Ube2k ubiquitin-conjugating enzyme E2K increases expression ISO Mechlorethamine results in increased expression of UBE2K mRNA CTD PMID:17107856 NCBI chr14:42,658,016...42,718,899
Ensembl chr14:42,658,016...42,718,630 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      biological role 19805
        aetiopathogenetic role 19180
          genotoxin 17668
            mutagen 17586
              alkylating agent 14328
                mechlorethamine 161
                  mechlorethamine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            heteroorganic entity 19477
                              organohalogen compound 18507
                                organochlorine compound 18307
                                  mechlorethamine 161
                                    mechlorethamine hydrochloride 0
paths to the root