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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fosfomycin
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Accession:CHEBI:28915 term browser browse the term
Definition:A phosphonic acid having an (R,S)-1,2-epoxypropyl group attached to phosphorus.
Synonyms:related_synonym: (-)-(1R,2S)-(1,2-Epoxypropyl)phosphonic acid;   (1R,2S)-epoxypropylphosphonic acid;   (2R-cis)-(3-Methyloxiranyl)phosphonic acid;   1R-cis-(1,2-epoxypropyl)phosphonic acid;   FCM;   Formula=C3H7O4P;   InChI=1S/C3H7O4P/c1-2-3(7-2)8(4,5)6/h2-3H,1H3,(H2,4,5,6)/t2-,3+/m0/s1;   InChIKey=YMDXZJFXQJVXBF-STHAYSLISA-N;   L-cis-1,2-epoxypropylphosphonic acid;   Phosphomycin;   Phosphonomycin;   SMILES=C[C@@H]1O[C@@H]1P(O)(O)=O;   [(2R,3S)-3-methyloxiran-2-yl]phosphonic acid;   cis-(1R,2S)-epoxypropylphosphonic acid;   fosfomicina;   fosfomycine;   fosfomycinum;   phosphonemycin
 alt_id: CHEBI:24100;   CHEBI:42503;   CHEBI:8159
 xref: CAS:23155-02-4;   DrugBank:DB00828;   Drug_Central:1243;   KEGG:C06454;   KEGG:D04253;   KNApSAcK:C00000789
 xref_mesh: MESH:D005578
 xref: MetaCyc:CPD0-1113;   PDBeChem:FCN;   PMID:105327;   PMID:17124631;   PMID:19308743;   PMID:2660079;   PMID:288976;   PMID:3464490;   PMID:3900889;   PMID:488578;   PMID:614140;   PMID:6348659;   PMID:6796449;   PMID:7030849;   PMID:7224844;   PMID:740308;   PMID:9309262;   Reaxys:1680831
 cyclic_relationship: is_conjugate_acid_of CHEBI:62247


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fosfomycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aqp5 aquaporin 5 decreases expression EXP Fosfomycin results in decreased expression of AQP5 protein CTD PMID:30031112 NCBI chr 7:141,249,044...141,252,576
Ensembl chr 7:141,249,044...141,252,578
JBrowse link
G Crp C-reactive protein decreases expression ISO Fosfomycin results in decreased expression of CRP protein CTD PMID:12680319 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        antimicrobial agent 17309
          fosfomycin 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  organic heteromonocyclic compound 16444
                                    saturated organic heteromonocyclic parent 5779
                                      oxirane 5746
                                        epoxide 5744
                                          fosfomycin 2
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