|
G |
Edn1 |
endothelin 1 |
increases expression |
ISO |
lignoceric acid results in increased expression of EDN1 protein |
CTD |
PMID:16895544 |
|
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
leptomycin B inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein] |
CTD |
PMID:10497241 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions increases phosphorylation |
ISO |
leptomycin B inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; leptomycin B inhibits the reaction [Formaldehyde affects the phosphorylation of AKT1 protein]; leptomycin B inhibits the reaction [Gefitinib results in decreased phosphorylation of AKT1 protein] leptomycin B results in increased phosphorylation of AKT1 protein |
CTD |
PMID:28942004 PMID:36534342 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Apaf1 |
apoptotic peptidase activating factor 1 |
multiple interactions |
ISO |
[leptomycin B co-treated with TP53 gene mutant form] results in increased expression of APAF1 mRNA |
CTD |
PMID:20803015 |
|
NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
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G |
Ar |
androgen receptor |
multiple interactions |
ISO |
leptomycin B inhibits the reaction [SB 216763 results in decreased localization of AR protein] |
CTD |
PMID:21980429 |
|
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Bach1 |
BTB domain and CNC homolog 1 |
affects localization multiple interactions |
ISO |
leptomycin B affects the localization of BACH1 protein leptomycin B inhibits the reaction [Cannabidiol results in decreased expression of BACH1 protein] leptomycin B inhibits the reaction [Cadmium Chloride affects the localization of BACH1 protein]; leptomycin B inhibits the reaction [Cadmium results in decreased activity of BACH1 protein] |
CTD |
PMID:14504288 PMID:31518892 |
|
NCBI chr11:26,939,429...26,974,876
Ensembl chr11:26,939,480...26,972,447
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
leptomycin B inhibits the reaction [Tretinoin results in increased expression of BAX protein] |
CTD |
PMID:14592536 |
|
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
leptomycin B inhibits the reaction [Tretinoin results in decreased expression of BCL2 protein] |
CTD |
PMID:14592536 |
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions |
ISO |
leptomycin B inhibits the reaction [Tretinoin results in decreased expression of BCL2L1 protein] |
CTD |
PMID:14592536 |
|
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
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G |
Birc2 |
baculoviral IAP repeat-containing 2 |
affects localization |
ISO |
leptomycin B affects the localization of BIRC2 protein |
CTD |
PMID:15265700 |
|
NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
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G |
Birc3 |
baculoviral IAP repeat-containing 3 |
affects localization |
ISO |
leptomycin B affects the localization of BIRC3 protein |
CTD |
PMID:15265700 |
|
NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
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|
G |
Birc5 |
baculoviral IAP repeat-containing 5 |
multiple interactions decreases expression |
ISO |
[epigallocatechin gallate co-treated with leptomycin B] results in decreased expression of BIRC5 mRNA; [epigallocatechin gallate co-treated with leptomycin B] results in decreased expression of BIRC5 protein; [leptomycin B co-treated with TP53 gene mutant form] results in increased expression of BIRC5 mRNA; leptomycin B promotes the reaction [gefitinib results in decreased expression of BIRC5 protein]; TP53 gene mutant form inhibits the reaction [leptomycin B results in decreased expression of BIRC5 protein] leptomycin B results in decreased expression of BIRC5 mRNA; leptomycin B results in decreased expression of BIRC5 protein |
CTD |
PMID:20803015 PMID:25922640 PMID:28942004 |
|
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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|
G |
Brca1 |
BRCA1, DNA repair associated |
multiple interactions decreases expression |
ISO |
[leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of BRCA1 mRNA leptomycin B results in decreased expression of BRCA1 mRNA |
CTD |
PMID:20803015 |
|
NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
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G |
Btg2 |
BTG anti-proliferation factor 2 |
increases expression |
ISO |
leptomycin B results in increased expression of BTG2 mRNA |
CTD |
PMID:20803015 |
|
NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
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|
G |
Casp1 |
caspase 1 |
multiple interactions |
ISO |
leptomycin B inhibits the reaction [[Lipopolysaccharides co-treated with aluminum sulfate] results in increased activity of CASP1 protein] |
CTD |
PMID:23430110 |
|
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
increases secretion multiple interactions |
ISO |
leptomycin B results in increased secretion of CCL2 protein polydatin inhibits the reaction [leptomycin B results in increased secretion of CCL2 protein] |
CTD |
PMID:21967610 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccnb2 |
cyclin B2 |
decreases expression |
ISO |
leptomycin B results in decreased expression of CCNB2 mRNA |
CTD |
PMID:20803015 |
|
NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
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G |
Ccnd1 |
cyclin D1 |
multiple interactions |
ISO |
leptomycin B inhibits the reaction [kahweol results in increased degradation of CCND1 protein] |
CTD |
PMID:27424123 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccne2 |
cyclin E2 |
decreases expression |
ISO |
leptomycin B results in decreased expression of CCNE2 mRNA |
CTD |
PMID:20803015 |
|
NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
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G |
Cdc25a |
cell division cycle 25A |
decreases expression |
ISO |
leptomycin B results in decreased expression of CDC25A mRNA |
CTD |
PMID:20803015 |
|
NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
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G |
Cdc25c |
cell division cycle 25C |
decreases expression |
ISO |
leptomycin B results in decreased expression of CDC25C mRNA |
CTD |
PMID:20803015 |
|
NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
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G |
Cdk1 |
cyclin-dependent kinase 1 |
decreases expression |
ISO |
leptomycin B results in decreased expression of CDK1 mRNA |
CTD |
PMID:20803015 |
|
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions increases expression |
ISO |
[epigallocatechin gallate co-treated with leptomycin B] results in increased expression of CDKN1A mRNA; [epigallocatechin gallate co-treated with leptomycin B] results in increased expression of CDKN1A protein; leptomycin B inhibits the reaction [gefitinib results in decreased expression of CDKN1A protein]; TP53 gene mutant form inhibits the reaction [leptomycin B results in increased expression of CDKN1A protein] leptomycin B results in increased expression of CDKN1A mRNA; leptomycin B results in increased expression of CDKN1A protein |
CTD |
PMID:20803015 PMID:25922640 PMID:28942004 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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|
G |
Chek1 |
checkpoint kinase 1 |
decreases expression |
ISO |
leptomycin B results in decreased expression of CHEK1 mRNA |
CTD |
PMID:20803015 |
|
NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
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G |
Chek2 |
checkpoint kinase 2 |
multiple interactions |
ISO |
[leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of CHEK2 mRNA |
CTD |
PMID:20803015 |
|
NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
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G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
decreases secretion multiple interactions |
ISO |
leptomycin B results in decreased secretion of CXCL10 protein acteoside promotes the reaction [leptomycin B results in decreased secretion of CXCL10 protein]; Quercetin promotes the reaction [leptomycin B results in decreased secretion of CXCL10 protein] |
CTD |
PMID:21967610 |
|
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
increases expression multiple interactions |
ISO |
leptomycin B results in increased expression of CYP3A4 mRNA [epigallocatechin gallate co-treated with leptomycin B] results in increased expression of CYP3A4 mRNA |
CTD |
PMID:25922640 |
|
NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
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G |
Dnmt1 |
DNA methyltransferase 1 |
multiple interactions decreases expression |
ISO |
[leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of DNMT1 mRNA leptomycin B results in decreased expression of DNMT1 mRNA |
CTD |
PMID:20803015 |
|
NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
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G |
E2f1 |
E2F transcription factor 1 |
decreases expression |
ISO |
leptomycin B results in decreased expression of E2F1 mRNA |
CTD |
PMID:20803015 |
|
NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
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G |
E2f3 |
E2F transcription factor 3 |
increases expression |
ISO |
leptomycin B results in increased expression of E2F3 mRNA |
CTD |
PMID:20803015 |
|
NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253
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G |
Egf |
epidermal growth factor |
multiple interactions |
ISO |
leptomycin B inhibits the reaction [EGF protein affects the localization of SET protein alternative form]; leptomycin B inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:36534342 |
|
NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
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G |
Ei24 |
EI24, autophagy associated transmembrane protein |
increases expression |
ISO |
leptomycin B results in increased expression of EI24 mRNA |
CTD |
PMID:20803015 |
|
NCBI chr 8:36,494,289...36,510,653
Ensembl chr 8:36,494,289...36,510,571
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
leptomycin B inhibits the reaction [Estradiol results in increased degradation of ESR1 protein] |
CTD |
PMID:15899841 |
|
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Fgf1 |
fibroblast growth factor 1 |
multiple interactions |
ISO |
leptomycin B results in decreased localization of and results in increased phosphorylation of FGF1 protein |
CTD |
PMID:15574884 |
|
NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
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G |
Foxo1 |
forkhead box O1 |
affects localization |
ISO |
leptomycin B affects the localization of FOXO1 protein |
CTD |
PMID:26026911 |
|
NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
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|
G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
increases expression |
ISO |
leptomycin B results in increased expression of GADD45A mRNA |
CTD |
PMID:20803015 |
|
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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G |
Gpx1 |
glutathione peroxidase 1 |
increases expression multiple interactions |
ISO |
leptomycin B results in increased expression of GPX1 mRNA [epigallocatechin gallate co-treated with leptomycin B] results in increased expression of GPX1 mRNA |
CTD |
PMID:25922640 |
|
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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|
G |
H2ax |
H2A.X variant histone |
multiple interactions |
ISO |
leptomycin B promotes the reaction [Bortezomib results in increased expression of H2AX protein modified form] |
CTD |
PMID:16778179 |
|
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 Ensembl chr 4:44,671,786...44,673,239
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G |
Hax1 |
HCLS1 associated protein X-1 |
affects localization |
ISO |
leptomycin B affects the localization of HAX1 protein |
CTD |
PMID:23164465 |
|
NCBI chr 2:175,434,242...175,437,926
Ensembl chr 2:175,434,238...175,437,714
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|
G |
Hk2 |
hexokinase 2 |
multiple interactions |
ISO |
[leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of HK2 mRNA |
CTD |
PMID:20803015 |
|
NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530
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G |
Id3 |
inhibitor of DNA binding 3 |
multiple interactions |
ISO |
leptomycin B inhibits the reaction [sodium arsenite affects the localization of ID3 protein] |
CTD |
PMID:23523789 |
|
NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
leptomycin B inhibits the reaction [[Lipopolysaccharides co-treated with aluminum sulfate] results in increased expression of IL1B protein] |
CTD |
PMID:23430110 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
[leptomycin B co-treated with TP53 gene mutant form] results in increased expression of IL6 mRNA |
CTD |
PMID:20803015 |
|
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases phosphorylation multiple interactions |
ISO |
leptomycin B results in increased phosphorylation of MAPK1 protein leptomycin B inhibits the reaction [gefitinib results in decreased phosphorylation of MAPK1 protein] |
CTD |
PMID:28942004 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions increases phosphorylation |
ISO |
leptomycin B inhibits the reaction [gefitinib results in decreased phosphorylation of MAPK3 protein] leptomycin B results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:28942004 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
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G |
Mdm2 |
MDM2 proto-oncogene |
increases expression |
ISO |
leptomycin B results in increased expression of MDM2 mRNA |
CTD |
PMID:20803015 |
|
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
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G |
Mdm4 |
MDM4 regulator of p53 |
multiple interactions |
ISO |
[leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of MDM4 mRNA |
CTD |
PMID:20803015 |
|
NCBI chr13:44,432,596...44,516,165
Ensembl chr13:44,406,213...44,474,226
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G |
Myh4 |
myosin heavy chain 4 |
multiple interactions |
EXP |
leptomycin B promotes the reaction [Potassium Chloride affects the localization of MYH4 protein] |
CTD |
PMID:29293066 |
|
NCBI chr10:51,923,149...51,946,297
Ensembl chr10:51,885,913...51,946,295
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
[leptomycin B co-treated with TP53 gene mutant form] results in increased expression of NFKB1 mRNA |
CTD |
PMID:20803015 |
|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nppa |
natriuretic peptide A |
multiple interactions |
EXP |
leptomycin B inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] |
CTD |
PMID:25341891 |
|
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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G |
Nr4a1 |
nuclear receptor subfamily 4, group A, member 1 |
multiple interactions |
ISO |
leptomycin B inhibits the reaction [Tretinoin affects the localization of [NR4A1 protein binds to RXRA protein]] |
CTD |
PMID:14592536 |
|
NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
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G |
Nr4a2 |
nuclear receptor subfamily 4, group A, member 2 |
multiple interactions |
ISO |
leptomycin B inhibits the reaction [sodium arsenite affects the localization of NR4A2 protein] |
CTD |
PMID:23283970 |
|
NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
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G |
Nup62 |
nucleoporin 62 |
multiple interactions |
EXP |
leptomycin B inhibits the reaction [Phenylephrine results in decreased expression of NUP62 protein] |
CTD |
PMID:25341891 |
|
NCBI chr 1:95,298,995...95,314,902
Ensembl chr 1:95,295,526...95,315,174
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G |
Oaz1 |
ornithine decarboxylase antizyme 1 |
increases localization |
EXP |
Leptomycin B increases localization of Oaz1 protein in the nucleus |
RGD |
PMID:12941943 |
RGD:401851056 |
NCBI chr 7:8,883,855...8,886,315
Ensembl chr 7:8,883,851...8,886,310
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G |
Pidd1 |
p53-induced death domain protein 1 |
increases expression |
ISO |
leptomycin B results in increased expression of PIDD1 mRNA |
CTD |
PMID:20803015 |
|
NCBI chr 1:196,536,815...196,542,808
Ensembl chr 1:196,536,834...196,542,699
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G |
Pml |
PML nuclear body scaffold |
multiple interactions |
ISO |
leptomycin B inhibits the reaction [Lipopolysaccharides results in increased localization of PML protein] |
CTD |
PMID:23430110 |
|
NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971
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G |
Prc1 |
protein regulator of cytokinesis 1 |
decreases expression |
ISO |
leptomycin B results in decreased expression of PRC1 mRNA |
CTD |
PMID:20803015 |
|
NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765
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G |
Prkca |
protein kinase C, alpha |
multiple interactions |
ISO |
[leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of PRKCA mRNA |
CTD |
PMID:20803015 |
|
NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
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G |
Pttg1 |
PTTG1 regulator of sister chromatid separation, securin |
decreases expression |
ISO |
leptomycin B results in decreased expression of PTTG1 mRNA |
CTD |
PMID:20803015 |
|
NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837
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G |
Ranbp1 |
RAN binding protein 1 |
affects localization multiple interactions |
EXP |
leptomycin B affects the localization of RANBP1 protein leptomycin B inhibits the reaction [Phenylephrine affects the localization of and affects the expression of RANBP1 protein] |
CTD |
PMID:10421839 PMID:25341891 |
|
NCBI chr11:82,742,603...82,750,836
Ensembl chr11:82,742,600...82,750,838
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
affects localization |
ISO |
leptomycin B affects the localization of RELA protein |
CTD |
PMID:25704882 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Rps6kb2 |
ribosomal protein S6 kinase B2 |
decreases activity |
ISO |
leptomycin B results in decreased activity of RPS6KB2 protein |
CTD |
PMID:12087098 |
|
NCBI chr 1:201,451,265...201,458,096
Ensembl chr 1:201,451,265...201,458,078
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|
G |
Rxra |
retinoid X receptor alpha |
multiple interactions |
ISO |
leptomycin B inhibits the reaction [Tretinoin affects the localization of [NR4A1 protein binds to RXRA protein]] |
CTD |
PMID:14592536 |
|
NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
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G |
Sesn1 |
sestrin 1 |
increases expression |
ISO |
leptomycin B results in increased expression of SESN1 mRNA |
CTD |
PMID:20803015 |
|
NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697
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G |
Set |
Set nuclear proto-oncogene |
multiple interactions |
ISO |
leptomycin B affects the reaction [Formaldehyde affects the localization of SET protein alternative form]; leptomycin B inhibits the reaction [EGF protein affects the localization of SET protein alternative form] |
CTD |
PMID:36534342 |
|
NCBI chr 3:13,334,564...13,345,598
Ensembl chr 3:13,335,041...13,363,567
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G |
Smad2 |
SMAD family member 2 |
multiple interactions |
ISO |
leptomycin B inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]; leptomycin B inhibits the reaction [arsenite inhibits the reaction [XPO4 protein results in increased export of SMAD2 protein]]; leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]; leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [XPO4 protein results in increased export of SMAD2 protein]] |
CTD |
PMID:26354774 |
|
NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
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G |
Smad3 |
SMAD family member 3 |
multiple interactions |
ISO |
leptomycin B inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]]; leptomycin B inhibits the reaction [arsenite inhibits the reaction [XPO4 protein results in increased export of SMAD3 protein]]; leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]]; leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [XPO4 protein results in increased export of SMAD3 protein]] |
CTD |
PMID:26354774 |
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NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
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G |
Smad4 |
SMAD family member 4 |
multiple interactions |
ISO |
[leptomycin B results in decreased activity of XPO1 protein] which results in decreased export of SMAD4 protein |
CTD |
PMID:26354774 |
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NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438
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G |
Snd1 |
staphylococcal nuclease and tudor domain containing 1 |
affects localization |
ISO |
leptomycin B affects the localization of SND1 protein |
CTD |
PMID:22240577 |
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NCBI chr 4:57,095,205...57,494,501
Ensembl chr 4:57,095,208...57,530,843
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G |
Sod2 |
superoxide dismutase 2 |
increases expression multiple interactions |
ISO |
leptomycin B results in increased expression of SOD2 mRNA [epigallocatechin gallate co-treated with leptomycin B] results in increased expression of SOD2 mRNA |
CTD |
PMID:25922640 |
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NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Sox9 |
SRY-box transcription factor 9 |
multiple interactions |
ISO |
leptomycin B inhibits the reaction [Warfarin affects the localization of SOX9 protein] |
CTD |
PMID:34520801 |
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NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994
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G |
Stat4 |
signal transducer and activator of transcription 4 |
affects localization |
ISO |
leptomycin B affects the localization of STAT4 protein |
CTD |
PMID:15004198 |
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NCBI chr 9:49,472,660...49,588,540
Ensembl chr 9:49,419,340...49,588,540
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G |
Stk4 |
serine/threonine kinase 4 |
multiple interactions |
ISO |
leptomycin B promotes the reaction [Bortezomib results in increased activity of STK4 protein] |
CTD |
PMID:16778179 |
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NCBI chr 3:152,745,958...152,827,747
Ensembl chr 3:152,745,681...152,827,744
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G |
Tgfb2 |
transforming growth factor, beta 2 |
multiple interactions |
ISO |
leptomycin B inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]; leptomycin B inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]]; leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]; leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]] |
CTD |
PMID:26354774 |
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NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
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G |
Tp53 |
tumor protein p53 |
multiple interactions increases response to substance increases expression affects expression decreases degradation |
ISO EXP |
3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [leptomycin B results in increased expression of TP53 protein]; [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of BRCA1 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of CHEK2 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of DNMT1 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of HK2 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of MDM4 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of PRKCA mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of TP63 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in increased expression of APAF1 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in increased expression of BIRC5 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in increased expression of IL6 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in increased expression of NFKB1 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in increased expression of TNFRSF10D mRNA; [sodium arsenite co-treated with leptomycin B] results in increased phosphorylation of TP53 protein; leptomycin B affects the localization of and results in decreased degradation of TP53 protein; leptomycin B inhibits the reaction [Cycloheximide results in increased degradation of TP53 protein]; leptomycin B inhibits the reaction [sodium arsenite affects the localization of TP53 protein]; leptomycin B inhibits the reaction [sodium arsenite results in increased degradation of TP53 protein mutant form]; leptomycin B inhibits the reaction [TP53 protein results in increased susceptibility to trichostatin A]; PCB 180 promotes the reaction [leptomycin B results in increased expression of TP53 protein]; Pravastatin inhibits the reaction [leptomycin B results in decreased degradation of TP53 protein]; TP53 gene mutant form inhibits the reaction [leptomycin B results in decreased expression of BIRC5 protein]; TP53 gene mutant form inhibits the reaction [leptomycin B results in increased expression of CDKN1A protein] TP53 gene mutant form results in increased susceptibility to leptomycin B alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [leptomycin B results in increased expression of TP53 protein]]; Tetrachlorodibenzodioxin inhibits the reaction [leptomycin B results in increased expression of TP53 protein] leptomycin B affects the expression of TP53 protein |
CTD |
PMID:11751435 PMID:15459018 PMID:15625077 PMID:16467109 PMID:19010883 PMID:19751709 PMID:20803015 PMID:21454520 PMID:24792400 PMID:31645432 More...
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Tp63 |
tumor protein p63 |
multiple interactions decreases expression |
ISO |
[leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of TP63 mRNA leptomycin B results in decreased expression of TP63 mRNA |
CTD |
PMID:20803015 |
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NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398
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G |
Txndc5 |
thioredoxin domain containing 5 |
increases expression multiple interactions |
ISO |
leptomycin B results in increased expression of TXNDC5 mRNA 1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane inhibits the reaction [leptomycin B results in increased expression of TXNDC5 mRNA] |
CTD |
PMID:24515801 |
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NCBI chr17:26,289,880...26,318,025
Ensembl chr17:26,289,880...26,318,025
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G |
Wtip |
WT1 interacting protein |
decreases localization |
ISO |
leptomycin B results in decreased localization of WTIP protein |
CTD |
PMID:14736876 |
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NCBI chr 1:86,731,214...86,764,939
Ensembl chr 1:86,731,265...86,765,014
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G |
Xpo1 |
exportin 1 |
decreases activity multiple interactions |
ISO |
leptomycin B results in decreased activity of XPO1 protein [leptomycin B results in decreased activity of XPO1 protein] which results in decreased export of SMAD4 protein |
CTD |
PMID:26354774 |
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NCBI chr14:97,233,282...97,275,536
Ensembl chr14:97,233,270...97,275,498
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G |
Xpo4 |
exportin 4 |
multiple interactions |
ISO |
leptomycin B inhibits the reaction [arsenite inhibits the reaction [XPO4 protein results in increased export of SMAD2 protein]]; leptomycin B inhibits the reaction [arsenite inhibits the reaction [XPO4 protein results in increased export of SMAD3 protein]]; leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [XPO4 protein results in increased export of SMAD2 protein]]; leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [XPO4 protein results in increased export of SMAD3 protein]] |
CTD |
PMID:26354774 |
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NCBI chr15:31,717,016...31,807,723
Ensembl chr15:31,716,762...31,807,908
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