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ONTOLOGY REPORT - ANNOTATIONS


Term:tobramycin
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Accession:CHEBI:28864 term browser browse the term
Definition:A amino cyclitol glycoside that is kanamycin B lacking the 3-hydroxy substituent from the 2,6-diaminoglucose ring.
Synonyms:exact_synonym: (1S,2S,3R,4S,6R)-4,6-diamino-3-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyloxy)-2-hydroxycyclohexyl 3-amino-3-deoxy-alpha-D-glucopyranoside
 related_synonym: 3'-Deoxykanamycin B;   Formula=C18H37N5O9;   InChI=1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+/m0/s1;   InChIKey=NLVFBUXFDBBNBW-PBSUHMDJSA-N;   Nebramycin 6;   Nebramycin factir 6;   O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribohexopyranosyl-(1-4))-2-deoxy-D-streptamine;   SMILES=NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O;   Tobracin (TN);   Tobrex (TN)
 alt_id: CHEBI:19849;   CHEBI:45933;   CHEBI:9610
 xref: CAS:32986-56-4;   DrugBank:DB00684;   Drug_Central:2684;   KEGG:C00397;   KEGG:D00063;   LINCS:LSM-6534
 xref_mesh: MESH:D014031
 xref: PDBeChem:TOY;   PMID:11000679;   PMID:11072877;   PMID:11459219;   PMID:11478352;   PMID:14961139;   PMID:15813341;   PMID:16205136;   PMID:16239129;   PMID:16478137;   PMID:16650821;   PMID:17150225;   PMID:18331849;   PMID:19072156;   PMID:19220547;   PMID:19340717;   PMID:19465435;   PMID:20000576;   PMID:20884302;   PMID:20938669;   PMID:21275493;   PMID:21343445;   PMID:21357290;   PMID:21396748;   PMID:21414310;   PMID:21429824;   PMID:21438171;   PMID:21530479;   PMID:21592592;   PMID:21726492;   PMID:21756818;   PMID:21796931;   PMID:21815282;   Reaxys:1357507;   Wikipedia:Tobramycin
 cyclic_relationship: is_conjugate_base_of CHEBI:73678


show annotations for term's descendants       view all columns           Sort by:
 
tobramycin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Anpep alanyl (membrane) aminopeptidase JBrowse link 7 79,821,803 79,848,210 RGD:6480464
G B2m beta-2 microglobulin JBrowse link 2 122,147,687 122,153,082 RGD:6480464
G Ctsb cathepsin B JBrowse link 14 63,122,462 63,145,923 RGD:6480464
G Elane elastase, neutrophil expressed JBrowse link 10 79,886,312 79,888,216 RGD:6480464
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha JBrowse link 6 67,035,096 67,037,407 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 8 75,093,618 75,100,593 RGD:6480464
G Muc5ac mucin 5, subtypes A and C, tracheobronchial/gastric JBrowse link 7 141,788,958 141,819,227 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 17 35,199,367 35,202,007 RGD:6480464
G Zfp36 zinc finger protein 36 JBrowse link 7 28,376,784 28,379,228 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21260
    role 21244
      biological role 21242
        antimicrobial agent 18124
          tobramycin 9
            nebramycin 5' 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 21260
    subatomic particle 21256
      composite particle 21256
        hadron 21256
          baryon 21256
            nucleon 21256
              atomic nucleus 21256
                atom 21256
                  main group element atom 21125
                    p-block element atom 21125
                      carbon group element atom 20894
                        carbon atom 20785
                          organic molecular entity 20785
                            heteroorganic entity 20483
                              organochalcogen compound 19614
                                organooxygen compound 19544
                                  carbohydrates and carbohydrate derivatives 12697
                                    carbohydrate 12697
                                      carbohydrate derivative 12325
                                        glycosyl compound 11021
                                          glycoside 9310
                                            aminoglycoside 8470
                                              aminoglycoside antibiotic 2523
                                                kanamycins 24
                                                  kanamycin B 9
                                                    tobramycin 9
                                                      nebramycin 5' 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.