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Accession:CHEBI:28864 term browser browse the term
Definition:A amino cyclitol glycoside that is kanamycin B lacking the 3-hydroxy substituent from the 2,6-diaminoglucose ring.
Synonyms:exact_synonym: (1S,2S,3R,4S,6R)-4,6-diamino-3-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyloxy)-2-hydroxycyclohexyl 3-amino-3-deoxy-alpha-D-glucopyranoside
 related_synonym: 3'-Deoxykanamycin B;   Formula=C18H37N5O9;   InChI=1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+/m0/s1;   InChIKey=NLVFBUXFDBBNBW-PBSUHMDJSA-N;   Nebramycin 6;   Nebramycin factir 6;   O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribohexopyranosyl-(1-4))-2-deoxy-D-streptamine;   SMILES=NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O;   Tobracin (TN);   Tobrex (TN)
 alt_id: CHEBI:19849;   CHEBI:45933;   CHEBI:9610
 xref: CAS:32986-56-4;   DrugBank:DB00684;   Drug_Central:2684;   KEGG:C00397;   KEGG:D00063;   LINCS:LSM-6534
 xref_mesh: MESH:D014031
 xref: PDBeChem:TOY;   PMID:11000679;   PMID:11072877;   PMID:11459219;   PMID:11478352;   PMID:14961139;   PMID:15813341;   PMID:16205136;   PMID:16239129;   PMID:16478137;   PMID:16650821;   PMID:17150225;   PMID:18331849;   PMID:19072156;   PMID:19220547;   PMID:19340717;   PMID:19465435;   PMID:20000576;   PMID:20884302;   PMID:20938669;   PMID:21275493;   PMID:21343445;   PMID:21357290;   PMID:21396748;   PMID:21414310;   PMID:21429824;   PMID:21438171;   PMID:21530479;   PMID:21592592;   PMID:21726492;   PMID:21756818;   PMID:21796931;   PMID:21815282;   Reaxys:1357507;   Wikipedia:Tobramycin
 cyclic_relationship: is_conjugate_base_of CHEBI:73678

show annotations for term's descendants       view all columns           Sort by:
tobramycin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ANPEP alanyl aminopeptidase, membrane JBrowse link 15 89,784,895 89,814,852 RGD:6480464
G B2M beta-2-microglobulin JBrowse link 15 44,711,492 44,718,145 RGD:6480464
G CTSB cathepsin B JBrowse link 8 11,842,524 11,868,118 RGD:6480464
G ELANE elastase, neutrophil expressed JBrowse link 19 850,997 856,250 RGD:6480464
G GADD45A growth arrest and DNA damage inducible alpha JBrowse link 1 67,685,201 67,688,334 RGD:6480464
G HMOX1 heme oxygenase 1 JBrowse link 22 35,381,096 35,394,207 RGD:6480464
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming JBrowse link 11 1,157,953 1,201,138 RGD:6480464
G SMN2 survival of motor neuron 2, centromeric JBrowse link 5 70,049,523 70,077,595 RGD:6480464
G TNF tumor necrosis factor JBrowse link 6 31,575,565 31,578,336 RGD:6480464
G ZFP36 ZFP36 ring finger protein JBrowse link 19 39,406,847 39,409,407 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 23948
    role 23836
      biological role 23799
        antimicrobial agent 20237
          tobramycin 10
            nebramycin 5' 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 23948
    subatomic particle 23899
      composite particle 23899
        hadron 23899
          baryon 23899
            nucleon 23899
              atomic nucleus 23899
                atom 23899
                  main group element atom 23720
                    p-block element atom 23720
                      carbon group element atom 23436
                        carbon atom 23392
                          organic molecular entity 23392
                            heteroorganic entity 23018
                              organochalcogen compound 22503
                                organooxygen compound 22422
                                  carbohydrates and carbohydrate derivatives 12969
                                    carbohydrate 12969
                                      carbohydrate derivative 12595
                                        glycosyl compound 11612
                                          glycoside 9748
                                            aminoglycoside 8888
                                              aminoglycoside antibiotic 2522
                                                kanamycins 25
                                                  kanamycin B 10
                                                    tobramycin 10
                                                      nebramycin 5' 0
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.