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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tobramycin
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Accession:CHEBI:28864 term browser browse the term
Definition:A amino cyclitol glycoside that is kanamycin B lacking the 3-hydroxy substituent from the 2,6-diaminoglucose ring.
Synonyms:exact_synonym: (1S,2S,3R,4S,6R)-4,6-diamino-3-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyloxy)-2-hydroxycyclohexyl 3-amino-3-deoxy-alpha-D-glucopyranoside
 related_synonym: 3'-Deoxykanamycin B;   Formula=C18H37N5O9;   InChI=1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+/m0/s1;   InChIKey=NLVFBUXFDBBNBW-PBSUHMDJSA-N;   Nebramycin 6;   Nebramycin factir 6;   O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribohexopyranosyl-(1-4))-2-deoxy-D-streptamine;   SMILES=NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O;   Tobracin (TN);   Tobrex (TN)
 alt_id: CHEBI:19849;   CHEBI:45933;   CHEBI:9610
 xref: CAS:32986-56-4;   DrugBank:DB00684;   Drug_Central:2684;   KEGG:C00397;   KEGG:D00063;   LINCS:LSM-6534
 xref_mesh: MESH:D014031
 xref: PDBeChem:TOY;   PMID:11000679;   PMID:11072877;   PMID:11459219;   PMID:11478352;   PMID:14961139;   PMID:15813341;   PMID:16205136;   PMID:16239129;   PMID:16478137;   PMID:16650821;   PMID:17150225;   PMID:18331849;   PMID:19072156;   PMID:19220547;   PMID:19340717;   PMID:19465435;   PMID:20000576;   PMID:20884302;   PMID:20938669;   PMID:21275493;   PMID:21343445;   PMID:21357290;   PMID:21396748;   PMID:21414310;   PMID:21429824;   PMID:21438171;   PMID:21530479;   PMID:21592592;   PMID:21726492;   PMID:21756818;   PMID:21796931;   PMID:21815282;   Reaxys:1357507;   Wikipedia:Tobramycin
 cyclic_relationship: is_conjugate_base_of CHEBI:73678


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tobramycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anpep alanyl aminopeptidase, membrane decreases activity EXP Tobramycin results in decreased activity of ANPEP protein CTD PMID:6653171 NCBI chr 1:141,561,364...141,604,249
Ensembl chr 1:141,561,334...141,604,273
JBrowse link
G B2m beta-2 microglobulin increases expression ISO Tobramycin results in increased expression of B2M protein CTD PMID:2218653 NCBI chr 3:114,087,287...114,093,311
Ensembl chr 3:114,087,287...114,093,309
JBrowse link
G Ctsb cathepsin B affects activity EXP Tobramycin affects the activity of CTSB protein CTD PMID:6653171 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Elane elastase, neutrophil expressed multiple interactions ISO [Copper binds to Tobramycin] which results in decreased activity of ELANE protein CTD PMID:23072509 NCBI chr 7:12,638,320...12,640,168
Ensembl chr 7:12,638,322...12,640,232
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Tobramycin results in increased expression of GADD45A mRNA CTD PMID:26260164 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Tobramycin results in increased expression of HMOX1 mRNA; Tobramycin results in increased expression of HMOX1 protein CTD PMID:26260164 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO Tobramycin inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC mRNA]; Tobramycin inhibits the reaction [Lipopolysaccharides results in increased secretion of MUC5AC protein] CTD PMID:21414310 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Copper binds to Tobramycin] inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species] CTD PMID:23072509 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Zfp36 zinc finger protein 36 increases expression ISO Tobramycin results in increased expression of ZFP36 mRNA CTD PMID:26260164 NCBI chr 1:85,380,088...85,382,565
Ensembl chr 1:85,380,088...85,382,569
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19792
      biological role 19792
        antimicrobial agent 17383
          tobramycin 9
            nebramycin 5' 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            heteroorganic entity 19217
                              organochalcogen compound 18922
                                organooxygen compound 18846
                                  carbohydrates and carbohydrate derivatives 12248
                                    carbohydrate 12248
                                      carbohydrate derivative 11874
                                        glycosyl compound 10927
                                          glycoside 9219
                                            aminoglycoside 8427
                                              aminoglycoside antibiotic 2536
                                                kanamycins 24
                                                  kanamycin B 9
                                                    tobramycin 9
                                                      nebramycin 5' 0
paths to the root