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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tobramycin
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Accession:CHEBI:28864 term browser browse the term
Definition:A amino cyclitol glycoside that is kanamycin B lacking the 3-hydroxy substituent from the 2,6-diaminoglucose ring.
Synonyms:exact_synonym: (1S,2S,3R,4S,6R)-4,6-diamino-3-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyloxy)-2-hydroxycyclohexyl 3-amino-3-deoxy-alpha-D-glucopyranoside
 related_synonym: 3'-Deoxykanamycin B;   Formula=C18H37N5O9;   InChI=1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+/m0/s1;   InChIKey=NLVFBUXFDBBNBW-PBSUHMDJSA-N;   Nebramycin 6;   Nebramycin factir 6;   O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribohexopyranosyl-(1-4))-2-deoxy-D-streptamine;   SMILES=NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O;   Tobracin (TN);   Tobrex (TN)
 alt_id: CHEBI:19849;   CHEBI:45933;   CHEBI:9610
 xref: CAS:32986-56-4;   DrugBank:DB00684;   Drug_Central:2684;   KEGG:C00397;   KEGG:D00063;   LINCS:LSM-6534
 xref_mesh: MESH:D014031
 xref: PDBeChem:TOY;   PMID:11000679;   PMID:11072877;   PMID:11459219;   PMID:11478352;   PMID:14961139;   PMID:15813341;   PMID:16205136;   PMID:16239129;   PMID:16478137;   PMID:16650821;   PMID:17150225;   PMID:18331849;   PMID:19072156;   PMID:19220547;   PMID:19340717;   PMID:19465435;   PMID:20000576;   PMID:20884302;   PMID:20938669;   PMID:21275493;   PMID:21343445;   PMID:21357290;   PMID:21396748;   PMID:21414310;   PMID:21429824;   PMID:21438171;   PMID:21530479;   PMID:21592592;   PMID:21726492;   PMID:21756818;   PMID:21796931;   PMID:21815282;   Reaxys:1357507;   Wikipedia:Tobramycin
 cyclic_relationship: is_conjugate_base_of CHEBI:73678


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tobramycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anpep alanyl aminopeptidase, membrane decreases activity EXP Tobramycin results in decreased activity of ANPEP protein CTD PMID:6653171 NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789 		JBrowse link
G B2m beta-2 microglobulin increases expression ISO Tobramycin results in increased expression of B2M protein CTD PMID:2218653 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766 		JBrowse link
G Ctsb cathepsin B affects activity EXP Tobramycin affects the activity of CTSB protein CTD PMID:6653171 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Elane elastase, neutrophil expressed multiple interactions ISO [Copper binds to Tobramycin] which results in decreased activity of ELANE protein CTD PMID:23072509 NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Tobramycin results in increased expression of GADD45A mRNA CTD PMID:26260164 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Tobramycin results in increased expression of HMOX1 mRNA; Tobramycin results in increased expression of HMOX1 protein CTD PMID:26260164 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO Tobramycin inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC mRNA]; Tobramycin inhibits the reaction [Lipopolysaccharides results in increased secretion of MUC5AC protein] CTD PMID:21414310 NCBI chr 1:196,864,375...196,896,475
Ensembl chr 1:196,864,336...196,896,475 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Copper binds to Tobramycin] inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species] CTD PMID:23072509 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Zfp36 zinc finger protein 36 increases expression ISO Tobramycin results in increased expression of ZFP36 mRNA CTD PMID:26260164 NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19751
    role 19724
      biological role 19722
        antimicrobial agent 17897
          tobramycin 9
            nebramycin 5' 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19751
    subatomic particle 19749
      composite particle 19749
        hadron 19749
          baryon 19749
            nucleon 19749
              atomic nucleus 19749
                atom 19749
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19644
                        carbon atom 19640
                          organic molecular entity 19640
                            heteroorganic entity 19399
                              organochalcogen compound 19189
                                organooxygen compound 19098
                                  carbohydrates and carbohydrate derivatives 14437
                                    carbohydrate 14437
                                      carbohydrate derivative 14191
                                        glycosyl compound 12944
                                          glycoside 11759
                                            aminoglycoside 11184
                                              aminoglycoside antibiotic 7519
                                                kanamycins 31
                                                  kanamycin B 9
                                                    tobramycin 9
                                                      nebramycin 5' 0
paths to the root