CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: beta-D-glucuronic acid
Accession: CHEBI:28860
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Definition: A D-glucopyranuronic acid in which the anomeric centre has beta-configuration.
Synonyms: exact_synonym: (2S,3S,4S,5R,6R)-3,4,5,6-tetrahydroxytetrahydro-2H-pyran-2-carboxylic acid
related_synonym: Formula=C6H10O7; GlcAb; GlcAbeta; InChI=1S/C6H10O7/c7-1-2(8)4(5(10)11)13-6(12)3(1)9/h1-4,6-9,12H,(H,10,11)/t1-,2-,3+,4-,6+/m0/s1; InChIKey=AEMOLEFTQBMNLQ-QIUUJYRFSA-N; SMILES=O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=O; beta-D-GlcpA; beta-D-Glucopyranuronic acid
alt_id: CHEBI:10395; CHEBI:21016; CHEBI:40973
xref: Beilstein:1427744; Gmelin:2497864; KEGG:C08350; KNApSAcK:C00001123; MetaCyc:CPD-12521; PDBeChem:BDP; PMID:19443021; PMID:22770225; PMID:25568069; PMID:31537530; PMID:35774810; Reaxys:1427744; Wikipedia:Glucuronic_acid
cyclic_relationship: is_conjugate_acid_of CHEBI:85313
G
Abcc3
ATP-binding cassette, sub-family C member 3
increases activity affects export multiple interactions
ISO EXP
acetaminophen glucuronide results in increased activity of ABCC3 protein ABCC3 protein affects the export of acetaminophen glucuronide Ethinyl Estradiol promotes the reaction [ABCC3 protein results in increased secretion of acetaminophen glucuronide]
CTD
PMID:16250050 PMID:16554369 PMID:17569508
NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823
G
Ins2
insulin II
increases abundance
ISO
INS protein results in increased abundance of acetaminophen glucuronide
CTD
PMID:26739624
NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118
G
Ogt
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
multiple interactions
EXP
OGT gene mutant form inhibits the reaction [Acetaminophen results in increased abundance of acetaminophen glucuronide]
CTD
PMID:29325178
NCBI chr X:100,683,617...100,727,957
Ensembl chr X:100,683,666...100,727,957
G
Kl
klotho
multiple interactions
EXP
androsterone glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]
CTD
PMID:14701853
NCBI chr 5:150,876,072...150,917,282
Ensembl chr 5:150,876,072...150,917,282
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