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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:beta-D-glucuronic acid
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Accession:CHEBI:28860 term browser browse the term
Definition:A D-glucopyranuronic acid in which the anomeric centre has beta-configuration.
Synonyms:exact_synonym: (2S,3S,4S,5R,6R)-3,4,5,6-tetrahydroxytetrahydro-2H-pyran-2-carboxylic acid
 related_synonym: Formula=C6H10O7;   GlcAb;   GlcAbeta;   InChI=1S/C6H10O7/c7-1-2(8)4(5(10)11)13-6(12)3(1)9/h1-4,6-9,12H,(H,10,11)/t1-,2-,3+,4-,6+/m0/s1;   InChIKey=AEMOLEFTQBMNLQ-QIUUJYRFSA-N;   SMILES=O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=O;   beta-D-Glucopyranuronic acid
 alt_id: CHEBI:10395;   CHEBI:21016;   CHEBI:40973
 xref: Beilstein:1427744;   Gmelin:2497864;   KEGG:C08350;   KNApSAcK:C00001123;   MetaCyc:CPD-12521;   PDBeChem:BDP;   PMID:19443021;   PMID:22770225;   PMID:25568069;   PMID:31537530;   Reaxys:1427744;   Wikipedia:Glucuronic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:85313


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acetaminophen O-beta-D-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP binding cassette subfamily C member 3 increases activity
affects export
multiple interactions
ISO
EXP
acetaminophen glucuronide results in increased activity of ABCC3 protein
ABCC3 protein affects the export of acetaminophen glucuronide
Ethinyl Estradiol promotes the reaction [ABCC3 protein results in increased secretion of acetaminophen glucuronide]
CTD PMID:16250050, PMID:16554369, PMID:17569508 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Ins2 insulin 2 increases abundance ISO INS protein results in increased abundance of acetaminophen glucuronide CTD PMID:26739624 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase multiple interactions ISO OGT gene mutant form inhibits the reaction [Acetaminophen results in increased abundance of acetaminophen glucuronide] CTD PMID:29325178 NCBI chr  X:71,540,870...71,585,906
Ensembl chr  X:71,528,988...71,585,908
JBrowse link
androsterone 3-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kl Klotho multiple interactions ISO androsterone glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] CTD PMID:14701853 NCBI chr12:942,974...987,206
Ensembl chr12:943,006...987,551
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            beta-D-glucuronic acid 4
              2-Me-alpha-D-Fucp4NAc-(1->4)-beta-D-GlcpA 0
              3-indole carboxylic acid glucuronide 0
              5-(3',5'-dihydroxyphenyl)-valeric acid-O-glucuronide 0
              acetaminophen O-beta-D-glucosiduronic acid 3
              alpha-D-GlcpNAc-(1->4)-beta-D-GlcpA 0
              androsterone 3-glucosiduronic acid 1
              beta-D-GlcpA-(1->3)-beta-D-GalpNAc4S 0
              beta-D-GlcpA-(1->3)-beta-D-GalpNAc6S 0
              beta-D-GlcpA-(1->4)-D-Xylp 0
              beta-D-GlcpNAc-(1->4)-beta-D-GlcpA 0
              beta-D-Xylp-(1->3)-beta-D-GlcpA 0
              beta-D-Xylp-(1->4)-beta-D-GlcpA 0
              beta-D-glucuronamide 0
              cytosylglucuronic acid 0
              dehydroisoandrosterone 3-glucuronide 0
              kaempferol O-glucuronide + 0
              luteolin O-glucuronoside + 0
              methyl beta-D-glucopyranuronate 0
              methyl beta-D-glucuronoside 0
              mycophenolic acid O-acyl-glucuronide 0
              myricetin O-glucuronide + 0
              octanoyl-beta-D-glucuronide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        monocarboxylic acid 17406
                                          uronic acid 14
                                            hexuronic acid 14
                                              glucuronic acids 13
                                                glucuronic acid 11
                                                  D-glucuronic acid 10
                                                    D-glucopyranuronic acid 10
                                                      beta-D-glucuronic acid 4
                                                        2-Me-alpha-D-Fucp4NAc-(1->4)-beta-D-GlcpA 0
                                                        3-indole carboxylic acid glucuronide 0
                                                        5-(3',5'-dihydroxyphenyl)-valeric acid-O-glucuronide 0
                                                        acetaminophen O-beta-D-glucosiduronic acid 3
                                                        alpha-D-GlcpNAc-(1->4)-beta-D-GlcpA 0
                                                        androsterone 3-glucosiduronic acid 1
                                                        beta-D-GlcpA-(1->3)-beta-D-GalpNAc4S 0
                                                        beta-D-GlcpA-(1->3)-beta-D-GalpNAc6S 0
                                                        beta-D-GlcpA-(1->4)-D-Xylp 0
                                                        beta-D-GlcpNAc-(1->4)-beta-D-GlcpA 0
                                                        beta-D-Xylp-(1->3)-beta-D-GlcpA 0
                                                        beta-D-Xylp-(1->4)-beta-D-GlcpA 0
                                                        beta-D-glucuronamide 0
                                                        cytosylglucuronic acid 0
                                                        dehydroisoandrosterone 3-glucuronide 0
                                                        kaempferol O-glucuronide + 0
                                                        luteolin O-glucuronoside + 0
                                                        methyl beta-D-glucopyranuronate 0
                                                        methyl beta-D-glucuronoside 0
                                                        mycophenolic acid O-acyl-glucuronide 0
                                                        myricetin O-glucuronide + 0
                                                        octanoyl-beta-D-glucuronide 0
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