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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:phenanthrene
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Accession:CHEBI:28851 term browser browse the term
Definition:A polycyclic aromatic hydrocarbon composed of three fused benzene rings which takes its name from the two terms 'phenyl' and 'anthracene.'
Synonyms:related_synonym: Formula=C14H10;   InChI=1S/C14H10/c1-3-7-13-11(5-1)9-10-12-6-2-4-8-14(12)13/h1-10H;   InChIKey=YNPNZTXNASCQKK-UHFFFAOYSA-N;   Phenanthracene;   Phenanthren;   SMILES=c1ccc2c(c1)ccc1ccccc21
 alt_id: CHEBI:25951;   CHEBI:44893;   CHEBI:8051
 xref: Beilstein:1905428;   CAS:85-01-8;   DrugBank:DB08381;   Gmelin:28699;   KEGG:C11422
 xref_mesh: MESH:C031181
 xref: MetaCyc:CPD-13485;   PDBeChem:PEY;   PMID:11472527;   PMID:24216621;   PMID:24722053;   Reaxys:1905428;   UM-BBD_compID:c0431;   Wikipedia:Phenanthrene


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phenanthrene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp2 acid phosphatase 2, lysosomal multiple interactions
affects expression		 ISO [naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] affects the expression of ACP2 protein
phenanthrene affects the expression of ACP2 protein		 CTD PMID:28803881 NCBI chr 3:77,175,022...77,185,180
Ensembl chr 3:77,175,895...77,185,680 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases activity
affects binding		 EXP
ISO		 phenanthrene binds to and results in increased activity of AHR protein
phenanthrene results in increased activity of AHR protein
[acenaphthene co-treated with anthracene co-treated with 1,12-benzoperylene co-treated with 1,2,5,6-dibenzanthracene co-treated with fluorene co-treated with naphthalene co-treated with phenanthrene] results in increased activity of AHR protein; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AHR protein; [phenanthrene co-treated with naphthalene] inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein]; [pyrene co-treated with phenanthrene] inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein]; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AR protein]; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ESR1 protein]; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AHR protein]; phenanthrene inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein]
phenanthrene binds to AHR protein		 CTD PMID:3024361 PMID:12850102 PMID:17665671 PMID:28710019 PMID:29502740 More... NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor multiple interactions ISO [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AHRR protein; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AHR protein]; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of CYP1A1 protein] CTD PMID:28710019 PMID:30980910 NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO phenanthrene results in increased phosphorylation of AKT1 protein CTD PMID:34453960 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 increases expression ISO phenanthrene results in increased expression of ALDH3A1 mRNA CTD PMID:32890658 NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681 		JBrowse link
G Ar androgen receptor affects binding
multiple interactions		 EXP
ISO		 phenanthrene analog binds to AR protein
phenanthrene analog inhibits the reaction [Androgens binds to AR protein]; phenanthrene analog inhibits the reaction [Metribolone binds to AR protein]; phenanthrene inhibits the reaction [Metribolone binds to AR protein]
[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AR protein; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AR protein]; phenanthrene inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; phenanthrene inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]		 CTD PMID:3695475 PMID:6323860 PMID:26022396 PMID:30980910 PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of ARNT protein; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of ARNT mRNA; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ARNT mRNA CTD PMID:28710019 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
affects expression		 ISO [naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] affects the expression of BAX protein
phenanthrene affects the expression of BAX protein		 CTD PMID:28803881 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Becn1 beclin 1 multiple interactions
decreases expression		 ISO Sirolimus inhibits the reaction [phenanthrene results in decreased expression of BECN1 mRNA] CTD PMID:34453960 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression		 ISO [naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] results in increased expression of CASP3 protein
phenanthrene results in increased expression of CASP3 protein		 CTD PMID:28803881 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase increases expression
increases activity
multiple interactions		 ISO phenanthrene results in increased expression of CAT protein
phenanthrene results in increased activity of CAT protein
[phenanthrene co-treated with fluorene] results in increased activity of CAT protein		 CTD PMID:20238386 PMID:32856796 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccna2 cyclin A2 decreases expression
multiple interactions		 ISO phenanthrene results in decreased expression of CCNA2 protein
[naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] results in decreased expression of CCNA2 protein		 CTD PMID:28803881 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression		 ISO [naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] results in increased expression of CCND1 protein
phenanthrene results in increased expression of CCND1 protein		 CTD PMID:28803881 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions
increases expression		 ISO [naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] results in increased expression of CDK2 protein
phenanthrene results in increased expression of CDK2 protein		 CTD PMID:28803881 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of COMT mRNA; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of and affects the activity of COMT protein CTD PMID:28710019 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
increases expression		 ISO [naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] affects the expression of CYP19A1 protein
phenanthrene results in increased expression of CYP19A1 protein		 CTD PMID:28803881 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases activity
increases metabolic processing
increases oxidation
increases expression		 ISO
EXP		 [CYP1A1 protein results in increased oxidation of phenanthrene] which results in increased abundance of 9-phenanthrol; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of CYP1A1 mRNA; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of CYP1A1 protein; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of CYP1A1 protein; [phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of CYP1A1 mRNA; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of CYP1A1 protein]; CYP1A1 protein results in increased metabolism of and results in increased activity of phenanthrene; GSTM1 gene polymorphism promotes the reaction [CYP1A1 gene polymorphism results in increased metabolism of phenanthrene]
phenanthrene results in increased activity of CYP1A1 protein
phenanthrene results in increased expression of CYP1A1 mRNA; phenanthrene results in increased expression of CYP1A1 protein		 CTD PMID:15566942 PMID:16906435 PMID:17035385 PMID:19766613 PMID:27137136 More... NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity
multiple interactions
increases oxidation
increases expression		 ISO phenanthrene results in increased activity of CYP1A2 protein
[CYP1A2 protein results in increased oxidation of phenanthrene] which results in increased abundance of 9-phenanthrol; CYP1A2 protein results in increased metabolism of and results in increased activity of phenanthrene
[acenaphthylene co-treated with acenaphthene co-treated with dibenzofuran co-treated with fluorene co-treated with phenanthrene co-treated with anthracene] results in increased expression of CYP1A2 mRNA; CYP1A2 protein results in increased metabolism of and results in increased activity of phenanthrene
phenanthrene results in increased expression of CYP1A2 mRNA; phenanthrene results in increased expression of CYP1A2 protein		 CTD PMID:7750161 PMID:8001243 PMID:19766613 PMID:27137136 PMID:31181217 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
decreases metabolic processing
increases oxidation
increases expression		 ISO [CYP1B1 protein results in increased oxidation of phenanthrene] which results in increased abundance of 9-phenanthrol; [phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of CYP1B1 mRNA; CYP1B1 protein results in increased metabolism of and results in increased activity of phenanthrene; phenanthrene binds to and results in decreased activity of CYP1B1 protein
CYP1B1 gene polymorphism results in decreased metabolism of phenanthrene
phenanthrene results in increased expression of CYP1B1 mRNA		 CTD PMID:15566942 PMID:17035385 PMID:19563207 PMID:19766613 PMID:27137136 More... NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 increases oxidation
multiple interactions
affects binding		 ISO CYP2A13 protein results in increased oxidation of phenanthrene
[CYP2A13 protein results in increased oxidation of phenanthrene] which results in increased abundance of 9-phenanthrol
phenanthrene binds to CYP2A13 protein		 CTD PMID:27137136 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression
multiple interactions		 ISO phenanthrene results in increased expression of CYP2B10 mRNA; phenanthrene results in increased expression of CYP2B10 protein
NR1I3 gene mutant form inhibits the reaction [phenanthrene results in increased expression of CYP2B10 mRNA]; NR1I3 gene mutant form inhibits the reaction [phenanthrene results in increased expression of CYP2B10 protein]		 CTD PMID:31181217 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO phenanthrene results in increased expression of CYP2B6 mRNA CTD PMID:31181217 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing ISO CYP2D6 protein results in increased metabolism of phenanthrene CTD PMID:9429232 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO CYP2E1 protein results in increased metabolism of and results in increased activity of phenanthrene CTD PMID:19766613 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Egr1 early growth response 1 increases expression ISO phenanthrene results in increased expression of EGR1 protein CTD PMID:15342960 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Eif4e eukaryotic translation initiation factor 4E increases expression ISO phenanthrene results in increased expression of EIF4E mRNA CTD PMID:34453960 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ESR1 protein; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ESR1 protein]; phenanthrene analog binds to and results in decreased activity of ESR1 protein; phenanthrene binds to and results in increased activity of ESR1 protein CTD PMID:12672240 PMID:30980910 PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 affects binding ISO phenanthrene analog binds to ESR2 protein CTD PMID:12672240 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Foxp3 forkhead box P3 decreases expression EXP phenanthrene results in decreased expression of FOXP3 mRNA; phenanthrene results in decreased expression of FOXP3 protein CTD PMID:31456356 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Gjb1 gap junction protein, beta 1 decreases expression EXP phenanthrene results in decreased expression of GJB1 protein CTD PMID:25268939 NCBI chr  X:66,501,848...66,509,783
Ensembl chr  X:66,501,820...66,509,925 		JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO phenanthrene results in increased expression of GSR protein CTD PMID:20238386 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 increases expression ISO phenanthrene results in increased expression of GSTA1 mRNA CTD PMID:32890658 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions
affects metabolic processing		 ISO GSTM1 gene polymorphism promotes the reaction [CYP1A1 gene polymorphism results in increased metabolism of phenanthrene]
GSTM1 protein affects the metabolism of phenanthrene		 CTD PMID:17035385 PMID:22674470 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 multiple interactions
increases expression		 ISO NR1I3 gene mutant form inhibits the reaction [phenanthrene results in increased expression of GSTM3 mRNA] CTD PMID:31181217 NCBI chr 2:195,531,627...195,534,562
Ensembl chr 2:195,531,495...195,534,553 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO phenanthrene results in increased expression of ICAM1 protein CTD PMID:22313677 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ier3 immediate early response 3 increases expression ISO phenanthrene results in increased expression of IER3 mRNA CTD PMID:22579512 NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583 		JBrowse link
G Ighe immunoglobulin heavy constant epsilon affects expression
increases expression		 ISO phenanthrene affects the expression of IGHE mRNA alternative form
phenanthrene results in increased expression of IGHE mRNA; phenanthrene results in increased expression of IGHE protein		 CTD PMID:9070347
G Il10 interleukin 10 decreases expression EXP phenanthrene results in decreased expression of IL10 mRNA; phenanthrene results in decreased expression of IL10 protein CTD PMID:31456356 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 EXP
ISO		 phenanthrene results in increased expression of IL6 mRNA; phenanthrene results in increased expression of IL6 protein
[fluorene co-treated with phenanthrene] results in increased expression of IL6 mRNA; [fluorene co-treated with phenanthrene] results in increased expression of IL6 protein		 CTD PMID:31456356 PMID:32856796 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Lgals1 galectin 1 increases expression ISO phenanthrene results in increased expression of LGALS1 mRNA CTD PMID:22579512 NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345 		JBrowse link
G Ndc80 NDC80 kinetochore complex component decreases expression ISO phenanthrene results in decreased expression of NDC80 mRNA CTD PMID:22579512 NCBI chr 9:111,407,191...111,440,921
Ensembl chr 9:111,407,191...111,440,924 		JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 multiple interactions ISO [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of NFKB2 protein CTD PMID:30980910 NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213 		JBrowse link
G Nlgn1 neuroligin 1 decreases expression ISO phenanthrene results in decreased expression of NLGN1 mRNA CTD PMID:34453960 NCBI chr 2:108,256,236...109,181,530
Ensembl chr 2:108,257,824...109,002,464 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression		 EXP
ISO		 phenanthrene results in increased activity of NQO1 protein
phenanthrene results in increased expression of NQO1 mRNA		 CTD PMID:16906435 PMID:31181217 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO phenanthrene binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity
multiple interactions		 ISO phenanthrene results in increased activity of NR1I3 protein
NR1I3 gene mutant form inhibits the reaction [phenanthrene results in increased expression of CYP2B10 mRNA]; NR1I3 gene mutant form inhibits the reaction [phenanthrene results in increased expression of CYP2B10 protein]; NR1I3 gene mutant form inhibits the reaction [phenanthrene results in increased expression of CYP3A11 mRNA]; NR1I3 gene mutant form inhibits the reaction [phenanthrene results in increased expression of GSTM3 mRNA]; NR1I3 gene mutant form inhibits the reaction [phenanthrene results in increased expression of SULT2A1 mRNA]; NR1I3 gene mutant form inhibits the reaction [phenanthrene results in increased expression of UGT1A1 mRNA]		 CTD PMID:28927721 PMID:31181217 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Pah phenylalanine hydroxylase decreases expression ISO phenanthrene results in decreased expression of PAH mRNA CTD PMID:22579512 NCBI chr 7:21,933,179...21,998,134
Ensembl chr 7:21,933,179...21,998,130 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO phenanthrene results in increased cleavage of PARP1 protein CTD PMID:21132278 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO phenanthrene inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein] CTD PMID:26022396 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 multiple interactions
decreases expression		 ISO phenanthrene affects the reaction [Tretinoin results in decreased expression of POU5F1 protein]
phenanthrene results in decreased expression of POU5F1 protein		 CTD PMID:21111795 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
G Rhoc ras homolog family member C increases expression ISO phenanthrene results in increased expression of RHOC mRNA CTD PMID:22579512 NCBI chr 2:192,287,065...192,293,292
Ensembl chr 2:192,287,130...192,295,306 		JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 multiple interactions
decreases expression		 ISO Sirolimus inhibits the reaction [phenanthrene results in decreased expression of SHANK3 mRNA] CTD PMID:34453960 NCBI chr 7:120,568,707...120,630,796
Ensembl chr 7:120,570,402...120,630,374 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO phenanthrene results in increased expression of SOD2 protein CTD PMID:20238386 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases expression
multiple interactions		 ISO phenanthrene results in increased expression of SULT2A1 mRNA
NR1I3 gene mutant form inhibits the reaction [phenanthrene results in increased expression of SULT2A1 mRNA]		 CTD PMID:31181217 NCBI chr 1:75,451,178...75,508,142
Ensembl chr 1:74,911,100...75,508,134 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression EXP phenanthrene results in decreased expression of TGFB1 mRNA; phenanthrene results in decreased expression of TGFB1 protein CTD PMID:31456356 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO phenanthrene results in increased expression of TIMP1 mRNA CTD PMID:22579512 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO
EXP		 [fluorene co-treated with phenanthrene] results in increased expression of TNF mRNA; [fluorene co-treated with phenanthrene] results in increased expression of TNF protein; TNF protein promotes the reaction [phenanthrene results in increased expression of CXCL8 mRNA]
phenanthrene results in increased expression of TNF mRNA; phenanthrene results in increased expression of TNF protein		 CTD PMID:18434080 PMID:31456356 PMID:32856796 PMID:34453960 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression
multiple interactions		 ISO phenanthrene results in increased expression of UGT1A1 mRNA
NR1I3 gene mutant form inhibits the reaction [phenanthrene results in increased expression of UGT1A1 mRNA]		 CTD PMID:31181217 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions ISO [phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of UGT1A6 mRNA CTD PMID:15566942 NCBI chr 9:88,747,229...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
9-phenanthrol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ano1 anoctamin 1 multiple interactions ISO 9-phenanthrol inhibits the reaction [Calcium results in increased activity of ANO1 protein] CTD PMID:25573456 NCBI chr 1:199,751,439...199,900,099
Ensembl chr 1:199,751,439...199,900,069 		JBrowse link
G Ar androgen receptor multiple interactions EXP
ISO		 9-phenanthrol inhibits the reaction [Metribolone binds to AR protein]
9-phenanthrol inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]		 CTD PMID:3695475 PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G C3 complement C3 increases expression ISO 9-phenanthrol results in increased expression of C3 mRNA CTD PMID:22989670 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases abundance
multiple interactions		 ISO CYP1A1 protein results in increased abundance of 9-phenanthrol
[CYP1A1 protein results in increased oxidation of phenanthrene] which results in increased abundance of 9-phenanthrol		 CTD PMID:27137136 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases abundance		 ISO [CYP1A2 protein results in increased oxidation of phenanthrene] which results in increased abundance of 9-phenanthrol
CYP1A2 protein results in increased abundance of 9-phenanthrol		 CTD PMID:27137136 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases abundance
multiple interactions		 ISO CYP1B1 protein results in increased abundance of 9-phenanthrol
[CYP1B1 protein results in increased oxidation of phenanthrene] which results in increased abundance of 9-phenanthrol		 CTD PMID:27137136 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 multiple interactions
increases abundance		 ISO [CYP2A13 protein results in increased oxidation of phenanthrene] which results in increased abundance of 9-phenanthrol
CYP2A13 protein results in increased abundance of 9-phenanthrol		 CTD PMID:27137136 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO 9-phenanthrol binds to and results in decreased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 affects binding
multiple interactions		 ISO ESR2 protein binds to 9-phenanthrol
9-phenanthrol inhibits the reaction [ESR2 protein binds to Estradiol]		 CTD PMID:22989670 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions ISO 9-phenanthrol inhibits the reaction [Lipopolysaccharides results in increased expression of FTH1 mRNA] CTD PMID:27246103 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G Gcg glucagon multiple interactions EXP 9-phenanthrol inhibits the reaction [[GCG protein co-treated with Glucose] results in increased secretion of INS1 protein] CTD PMID:29098165 NCBI chr 3:47,113,914...47,122,929
Ensembl chr 3:47,113,914...47,122,929 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO 9-phenanthrol inhibits the reaction [Hydrogen Peroxide results in increased secretion of ICAM1 protein] CTD PMID:28214884 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ins1 insulin 1 multiple interactions
increases secretion		 EXP 9-phenanthrol inhibits the reaction [[GCG protein co-treated with Glucose] results in increased secretion of INS1 protein]; 9-phenanthrol inhibits the reaction [Glucose results in increased secretion of INS1 protein]
9-phenanthrol results in increased secretion of INS1 protein		 CTD PMID:29098165 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Jag1 jagged canonical Notch ligand 1 decreases expression ISO 9-phenanthrol results in decreased expression of JAG1 mRNA CTD PMID:22989670 NCBI chr 3:124,406,794...124,442,220
Ensembl chr 3:124,406,794...124,442,209 		JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO 9-phenanthrol inhibits the reaction [Lipopolysaccharides affects the localization of NFATC1 protein] CTD PMID:27246103 NCBI chr18:74,046,421...74,156,041
Ensembl chr18:74,046,904...74,156,028 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO 9-phenanthrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; 9-phenanthrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:27246103 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO 9-phenanthrol binds to and affects the activity of NR1I2 protein
9-phenanthrol binds to and results in increased activity of NR1I2 protein		 CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nrip1 nuclear receptor interacting protein 1 increases expression ISO 9-phenanthrol results in increased expression of NRIP1 mRNA CTD PMID:22989670 NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO 9-phenanthrol binds to and affects the activity of PPARG protein
9-phenanthrol binds to and results in increased activity of PPARG protein		 CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 decreases activity ISO 9-phenanthrol results in decreased activity of SCN5A protein mutant form CTD PMID:30153324 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769 		JBrowse link
G Sele selectin E multiple interactions ISO 9-phenanthrol inhibits the reaction [Hydrogen Peroxide results in increased secretion of SELE protein] CTD PMID:28214884 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO 9-phenanthrol binds to and results in increased activity of THRA protein CTD PMID:33049310 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO 9-phenanthrol binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 multiple interactions
decreases activity		 ISO 9-phenanthrol inhibits the reaction [Arsenic Trioxide results in increased expression of TRPM4 protein]; 9-phenanthrol inhibits the reaction [Glutamic Acid results in increased activity of TRPM4 protein]; 9-phenanthrol inhibits the reaction [Hydrogen Peroxide results in increased expression of TRPM4 protein]
9-phenanthrol results in decreased activity of TRPM4 protein		 CTD PMID:25047048 PMID:28214884 PMID:31054354 PMID:34335274 NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532 		JBrowse link
G Trpm5 transient receptor potential cation channel, subfamily M, member 5 decreases activity ISO 9-phenanthrol results in decreased activity of TRPM5 protein CTD PMID:18297105 NCBI chr 1:198,254,956...198,277,824
Ensembl chr 1:198,255,723...198,277,654 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO 9-phenanthrol inhibits the reaction [Hydrogen Peroxide results in increased secretion of VCAM1 protein] CTD PMID:28214884 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19784
      chemical role 19418
        environmental contaminant 18820
          phenanthrene 76
            9-phenanthrol + 26
            perfluorophenanthrene 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19810
      composite particle 19810
        hadron 19810
          baryon 19810
            nucleon 19810
              atomic nucleus 19810
                atom 19810
                  main group element atom 19755
                    main group molecular entity 19755
                      s-block molecular entity 19605
                        hydrogen molecular entity 19595
                          hydrides 19072
                            organic hydride 18667
                              organic fundamental parent 18667
                                hydrocarbon 18414
                                  cyclic hydrocarbon 17223
                                    arene 17203
                                      polycyclic arene 17030
                                        ortho-fused polycyclic arene 9745
                                          phenanthrene 76
                                            9-phenanthrol + 26
                                            perfluorophenanthrene 0
paths to the root