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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:naphthazarin
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Accession:CHEBI:28849 term browser browse the term
Definition:A naphthoquinone that is 1,4-naphthoquinone in which the hydrogens at positions 5 and 8 are replaced by hydroxy groups.
Synonyms:related_synonym: 5,8-Dihydroxy-1,4-naphthoquinone;   5,8-dihydroxy-1,4-naphthalenedione;   5,8-dihydroxy-1,4-naphthosemiquinone;   5,8-dihydroxynaphthoquinone;   Formula=C10H6O4;   InChI=1S/C10H6O4/c11-5-1-2-6(12)10-8(14)4-3-7(13)9(5)10/h1-4,11-12H;   InChIKey=RQNVIKXOOKXAJQ-UHFFFAOYSA-N;   SMILES=Oc1ccc(O)c2C(=O)C=CC(=O)c12;   naphthazarine;   naphthazarone
 alt_id: CHEBI:20521;   CHEBI:7474
 xref: CAS:475-38-7;   KEGG:C01938;   KNApSAcK:C00002846
 xref_mesh: MESH:C005503
 xref: PMID:11667447;   PMID:15644912;   PMID:16019186;   PMID:17432383;   PMID:18309277;   PMID:21667044;   PMID:21765926;   PMID:21904775;   PMID:22513651;   PMID:23537652;   PMID:2435285;   PMID:24587235;   Reaxys:880561;   Wikipedia:5\,8-Dihydroxy-1\,4-naphthoquinone


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naphthazarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO naphthazarin results in increased expression of CYP1A1 mRNA CTD PMID:26558468 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) decreases activity EXP
ISO		 naphthazarin results in decreased activity of DHODH protein CTD PMID:10658902 NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      application 19622
        pesticide 17446
          acaricide 12691
            naphthazarin 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            organic group 18905
                              organic divalent group 18887
                                organodiyl group 18887
                                  carbonyl group 18853
                                    carbonyl compound 18853
                                      ketone 17140
                                        cyclic ketone 15688
                                          quinone 8548
                                            naphthoquinone 1452
                                              1,4-naphthoquinones 1439
                                                hydroxy-1,4-naphthoquinone 148
                                                  naphthazarin 2
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