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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:naphthazarin
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Accession:CHEBI:28849 term browser browse the term
Definition:A naphthoquinone that is 1,4-naphthoquinone in which the hydrogens at positions 5 and 8 are replaced by hydroxy groups.
Synonyms:related_synonym: 5,8-Dihydroxy-1,4-naphthoquinone;   5,8-dihydroxy-1,4-naphthalenedione;   5,8-dihydroxy-1,4-naphthosemiquinone;   5,8-dihydroxynaphthoquinone;   Formula=C10H6O4;   InChI=1S/C10H6O4/c11-5-1-2-6(12)10-8(14)4-3-7(13)9(5)10/h1-4,11-12H;   InChIKey=RQNVIKXOOKXAJQ-UHFFFAOYSA-N;   SMILES=Oc1ccc(O)c2C(=O)C=CC(=O)c12;   naphthazarine;   naphthazarone
 alt_id: CHEBI:20521;   CHEBI:7474
 xref: CAS:475-38-7;   KEGG:C01938;   KNApSAcK:C00002846
 xref_mesh: MESH:C005503
 xref: PMID:11667447;   PMID:15644912;   PMID:16019186;   PMID:17432383;   PMID:18309277;   PMID:21667044;   PMID:21904775;   PMID:22513651;   PMID:23537652;   PMID:2435285;   PMID:24587235;   Reaxys:880561;   Wikipedia:5\,8-Dihydroxy-1\,4-naphthoquinone


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naphthazarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO naphthazarin results in increased expression of CYP1A1 mRNA CTD PMID:26558468 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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G Dhodh dihydroorotate dehydrogenase (quinone) decreases activity EXP
ISO
naphthazarin results in decreased activity of DHODH protein CTD PMID:10658902 NCBI chr19:42,066,103...42,087,906
Ensembl chr19:42,066,351...42,082,012
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pesticide 16264
          acaricide 9039
            naphthazarin 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      ketone 16144
                                        cyclic ketone 13813
                                          quinone 8338
                                            naphthoquinone 1428
                                              1,4-naphthoquinones 1404
                                                hydroxy-1,4-naphthoquinone 124
                                                  naphthazarin 2
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