CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: dodecane
Accession: CHEBI:28817
browse the term
Definition: A straight-chain alkane with 12 carbon atoms. It has been isolated from the essential oils of various plants including Zingiber officinale (ginger).
Synonyms: related_synonym: Bihexyl; CH3-[CH2]10-CH3; Dihexyl; Dodekan; Formula=C12H26; InChI=1S/C12H26/c1-3-5-7-9-11-12-10-8-6-4-2/h3-12H2,1-2H3; InChIKey=SNRUBQQJIBEYMU-UHFFFAOYSA-N; SMILES=CCCCCCCCCCCC; n-Dodecane
alt_id: CHEBI:25464; CHEBI:41713; CHEBI:4675
xref: Beilstein:1697175; CAS:112-40-3; DrugBank:DB02771; Gmelin:201408; HMDB:HMDB0031444; KEGG:C08374; KNApSAcK:C00001248; LIPID_MAPS_instance:LMFA11000004
xref_mesh: MESH:C007548
xref: MetaCyc:CPD-9290; PDBeChem:D12; PMID:24493301; Reaxys:1697175; Wikipedia:Dodecane
G
Il1a
interleukin 1 alpha
multiple interactions
ISO
n-dodecane results in increased expression of and results in increased secretion of IL1A protein
CTD
PMID:19720135
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
G
Il6
interleukin 6
multiple interactions increases expression
ISO EXP
n-dodecane results in increased expression of and results in increased secretion of IL6 protein n-dodecane results in increased expression of IL6 protein
CTD
PMID:19152832 PMID:19720135
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Pomc
proopiomelanocortin
increases expression
EXP
n-dodecane results in increased expression of POMC protein modified form
CTD
PMID:19152832
NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
G
Tac1
tachykinin, precursor 1
increases expression
EXP
n-dodecane results in increased expression of TAC1 protein modified form
CTD
PMID:19152832
NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
G
Tnf
tumor necrosis factor
increases expression
EXP
n-dodecane results in increased expression of TNF protein
CTD
PMID:15451557
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Iyd
iodotyrosine deiodinase
multiple interactions
ISO
1-monomyristin inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine]
CTD
PMID:33352258
NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319
G
Adh5
alcohol dehydrogenase 5 (class III), chi polypeptide
increases oxidation affects binding
ISO
ADH5 protein results in increased oxidation of 12-hydroxydodecanoic acid 12-hydroxydodecanoic acid binds to ADH5 protein
CTD
PMID:12196016 PMID:12604204 PMID:19428350
NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591
G
Cyp4v3
cytochrome P450, family 4, subfamily v, polypeptide 3
multiple interactions increases chemical synthesis
ISO
2-chloro-5-nitrobenzanilide inhibits the reaction [CYP4V2 protein results in increased chemical synthesis of 12-hydroxydodecanoic acid]
CTD
PMID:28729181
NCBI chr16:46,917,929...46,958,735
Ensembl chr16:46,918,401...46,943,395
G
Atf3
activating transcription factor 3
increases expression
ISO
Dodecanol analog results in increased expression of ATF3 mRNA
CTD
PMID:27965148
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
G
Dnajb4
DnaJ heat shock protein family (Hsp40) member B4
increases expression
ISO
Dodecanol analog results in increased expression of DNAJB4 mRNA
CTD
PMID:27965148
NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089
G
Gclm
glutamate cysteine ligase, modifier subunit
increases expression
ISO
Dodecanol analog results in increased expression of GCLM mRNA
CTD
PMID:27965148
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
G
Adh5
alcohol dehydrogenase 5 (class III), chi polypeptide
multiple interactions
ISO
dodecanedioic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]
CTD
PMID:19428350
NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591
G
Adh5
alcohol dehydrogenase 5 (class III), chi polypeptide
multiple interactions
ISO
lauric acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]
CTD
PMID:19428350
NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591
G
Akt1
AKT serine/threonine kinase 1
multiple interactions
ISO
lauric acid inhibits the reaction [deoxynivalenol results in decreased phosphorylation of AKT1 protein]
CTD
PMID:34506767
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
G
Casp3
caspase 3
multiple interactions
ISO
lauric acid inhibits the reaction [deoxynivalenol results in increased cleavage of CASP3 protein]
CTD
PMID:34506767
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Cldn1
claudin 1
multiple interactions
ISO
lauric acid inhibits the reaction [deoxynivalenol results in decreased expression of CLDN1 protein]
CTD
PMID:34506767
NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
increases metabolic processing
ISO
CYP2E1 protein results in increased metabolism of lauric acid
CTD
PMID:12464242
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
G
Cyp4a1
cytochrome P450, family 4, subfamily a, polypeptide 1
affects metabolic processing
EXP
CYP4A1 protein affects the metabolism of lauric acid
CTD
PMID:15879494
NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
G
Cyp4a2
cytochrome P450, family 4, subfamily a, polypeptide 2
affects metabolic processing
EXP
CYP4A2 protein affects the metabolism of lauric acid
CTD
PMID:15879494
NCBI chr 5:128,922,355...128,934,188
Ensembl chr 5:128,923,615...128,934,165
G
Cyp4a3
cytochrome P450, family 4, subfamily a, polypeptide 3
affects metabolic processing
EXP
CYP4A3 protein affects the metabolism of lauric acid
CTD
PMID:15879494
NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463
G
Cyp4b1
cytochrome P450, family 4, subfamily b, polypeptide 1
multiple interactions
ISO
lauric acid inhibits the reaction [CYP4B1 protein results in increased metabolism of 3,3'-Dichlorobenzidine]
CTD
PMID:9310344
NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348
G
Krt20
keratin 20
multiple interactions
ISO
lauric acid inhibits the reaction [deoxynivalenol results in decreased expression of KRT20 protein]
CTD
PMID:34506767
NCBI chr10:84,384,790...84,394,125
Ensembl chr10:84,384,802...84,394,107
G
Lgr5
leucine rich repeat containing G protein coupled receptor 5
multiple interactions
ISO
lauric acid inhibits the reaction [deoxynivalenol results in decreased expression of LGR5 protein]
CTD
PMID:34506767
NCBI chr 7:51,087,059...51,221,882
Ensembl chr 7:51,088,239...51,222,446
G
Lyz2
lysozyme 2
multiple interactions
ISO
lauric acid inhibits the reaction [deoxynivalenol results in decreased expression of LYZ protein]
CTD
PMID:34506767
NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106
G
Mtor
mechanistic target of rapamycin kinase
multiple interactions
ISO
lauric acid inhibits the reaction [deoxynivalenol results in decreased phosphorylation of MTOR protein]
CTD
PMID:34506767
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
G
Muc2
mucin 2, oligomeric mucus/gel-forming
multiple interactions
ISO
lauric acid inhibits the reaction [deoxynivalenol results in decreased expression of MUC2 protein]
CTD
PMID:34506767
NCBI chr 1:196,799,494...196,831,740
Ensembl chr 1:196,799,517...196,831,756
G
Nod2
nucleotide-binding oligomerization domain containing 2
multiple interactions
ISO
Curcumin inhibits the reaction [lauric acid promotes the reaction [NOD2 protein binds to NOD2 protein]]; lauric acid promotes the reaction [NOD2 protein binds to NOD2 protein]
CTD
PMID:18413660
NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177
G
Ocln
occludin
multiple interactions
ISO
lauric acid inhibits the reaction [deoxynivalenol results in decreased expression of OCLN protein]
CTD
PMID:34506767
NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
G
Pcna
proliferating cell nuclear antigen
increases expression multiple interactions
ISO
lauric acid results in increased expression of PCNA protein lauric acid inhibits the reaction [deoxynivalenol results in decreased expression of PCNA protein]
CTD
PMID:34506767
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
G
Ppara
peroxisome proliferator activated receptor alpha
affects binding
ISO
lauric acid binds to PPARA protein
CTD
PMID:10403814
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
G
Ppargc1a
PPARG coactivator 1 alpha
increases expression
ISO
lauric acid results in increased expression of PPARGC1A mRNA
CTD
PMID:23056435
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions increases activity
ISO
Curcumin inhibits the reaction [lauric acid results in increased activity of RELA protein]; parthenolide inhibits the reaction [lauric acid results in increased activity of RELA protein]
CTD
PMID:18413660
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Rps6
ribosomal protein S6
multiple interactions
ISO
lauric acid inhibits the reaction [deoxynivalenol results in decreased phosphorylation of RPS6 protein]
CTD
PMID:34506767
NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602 Ensembl chr 5:101,371,136...101,374,602
G
Rps6kb1
ribosomal protein S6 kinase B1
multiple interactions
ISO
lauric acid inhibits the reaction [deoxynivalenol results in decreased phosphorylation of RPS6KB1 protein]
CTD
PMID:34506767
NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
G
Tjp1
tight junction protein 1
multiple interactions increases expression
ISO
lauric acid inhibits the reaction [deoxynivalenol results in decreased expression of TJP1 protein] lauric acid results in increased expression of TJP1 protein
CTD
PMID:34506767
NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
G
Ugt1a2
UDP glucuronosyltransferase 1 family, polypeptide A2
increases glucuronidation
ISO
UGT1A3 protein results in increased glucuronidation of lauric acid
CTD
PMID:16051554
NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Vil1
villin 1
multiple interactions
ISO
lauric acid inhibits the reaction [deoxynivalenol results in decreased expression of VIL1 protein]
CTD
PMID:34506767
NCBI chr 9:75,991,141...76,018,860
Ensembl chr 9:75,991,141...76,018,858
G
Gsta1
glutathione S-transferase alpha 1
multiple interactions
ISO
lauroyl-coenzyme A binds to and results in decreased activity of GSTA1 protein
CTD
PMID:10542059
NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
G
Hsdl2
hydroxysteroid dehydrogenase like 2
multiple interactions
ISO
[lauroyl-coenzyme A co-treated with NADP] binds to HSDL2 protein
CTD
PMID:25526675
NCBI chr 5:74,443,933...74,479,104
Ensembl chr 5:74,443,872...74,479,839
G
Pecr
peroxisomal trans-2-enoyl-CoA reductase
multiple interactions
ISO
[lauroyl-coenzyme A co-treated with NADP] binds to PECR protein
CTD
PMID:25526675
NCBI chr 9:73,897,877...73,926,511
Ensembl chr 9:73,897,880...73,926,511
G
Esr1
estrogen receptor 1
multiple interactions
ISO
lauric acid methyl ester binds to and results in increased activity of ESR1 protein
CTD
PMID:27633901
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
G
Esr2
estrogen receptor 2
multiple interactions
ISO
lauric acid methyl ester binds to and results in decreased activity of ESR2 protein; lauric acid methyl ester binds to and results in increased activity of ESR2 protein
CTD
PMID:27633901
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
G
Pgr
progesterone receptor
multiple interactions
ISO
lauric acid methyl ester binds to and results in decreased activity of PGR protein
CTD
PMID:27633901
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
lauric acid methyl ester binds to and results in decreased activity of PPARG protein
CTD
PMID:27633901
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
G
Thrb
thyroid hormone receptor beta
multiple interactions
ISO
lauric acid methyl ester binds to and results in decreased activity of THRB protein
CTD
PMID:27633901
NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
G
Abca1
ATP binding cassette subfamily A member 1
increases expression
ISO
perfluorododecanoic acid results in increased expression of ABCA1 mRNA
CTD
PMID:35337807
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
G
Abhd14b
abhydrolase domain containing 14b
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of ABHD14B protein
CTD
PMID:26168851
NCBI chr 8:107,087,157...107,092,122
Ensembl chr 8:107,088,069...107,092,119
G
Acot1
acyl-CoA thioesterase 1
increases expression multiple interactions
EXP
perfluorododecanoic acid results in increased expression of ACOT1 mRNA; perfluorododecanoic acid results in increased expression of ACOT1 protein perfluorododecanoic acid inhibits the reaction [GW 6471 results in decreased expression of ACOT1 mRNA]; perfluorododecanoic acid inhibits the reaction [pirinixic acid results in increased expression of ACOT1 mRNA]; PPARA mRNA promotes the reaction [perfluorododecanoic acid results in increased expression of ACOT1 mRNA]
CTD
PMID:26168851
NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163
G
Acot2
acyl-CoA thioesterase 2
multiple interactions increases expression
EXP ISO
perfluorododecanoic acid inhibits the reaction [GW 6471 results in decreased expression of ACOT2 mRNA]; perfluorododecanoic acid inhibits the reaction [pirinixic acid results in increased expression of ACOT2 mRNA]; PPARA mRNA promotes the reaction [perfluorododecanoic acid results in increased expression of ACOT2 mRNA] perfluorododecanoic acid results in increased expression of ACOT2 mRNA; perfluorododecanoic acid results in increased expression of ACOT2 protein
CTD
PMID:26168851 PMID:35337807
NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245
G
Acp1
acid phosphatase 1
increases expression
EXP
perfluorododecanoic acid results in increased expression of ACP1 protein
CTD
PMID:19854247
NCBI chr 6:47,506,380...47,522,021
Ensembl chr 6:47,506,380...47,522,021
G
Actg1
actin, gamma 1
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of ACTG1 protein
CTD
PMID:26168851
NCBI chr10:105,619,738...105,622,587
Ensembl chr10:105,619,737...105,624,232 Ensembl chr 3:105,619,737...105,624,232
G
Acy1
aminoacylase 1
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of ACY1 protein
CTD
PMID:26168851
NCBI chr 8:107,072,354...107,077,756
Ensembl chr 8:107,072,358...107,077,682
G
Adk
adenosine kinase
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of ADK protein
CTD
PMID:26168851
NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510
G
Ahcy
adenosylhomocysteinase
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of AHCY protein
CTD
PMID:26168851
NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393
G
Akap4
A-kinase anchoring protein 4
increases expression decreases expression
EXP
perfluorododecanoic acid results in increased expression of AKAP4 mRNA perfluorododecanoic acid results in decreased expression of AKAP4 protein
CTD
PMID:19854247
NCBI chr X:15,435,391...15,445,684
Ensembl chr X:15,435,410...15,445,684
G
Akt2
AKT serine/threonine kinase 2
decreases phosphorylation
EXP
perfluorododecanoic acid results in decreased phosphorylation of AKT2 protein
CTD
PMID:30489073
NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
G
Alb
albumin
increases expression decreases expression
EXP
perfluorododecanoic acid results in increased expression of ALB protein perfluorododecanoic acid results in decreased expression of ALB protein
CTD
PMID:19854247 PMID:26168851
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
G
Aldh2
aldehyde dehydrogenase 2 family member
decreases expression multiple interactions
EXP
perfluorododecanoic acid results in decreased expression of ALDH2 protein PPARA mRNA promotes the reaction [perfluorododecanoic acid results in decreased expression of ALDH2 protein]
CTD
PMID:26168851
NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
G
Aldh9a1
aldehyde dehydrogenase 9 family, member A1
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of ALDH9A1 protein
CTD
PMID:26168851
NCBI chr13:79,505,738...79,522,539
Ensembl chr13:79,505,695...79,540,568
G
Angptl4
angiopoietin-like 4
increases expression
ISO
perfluorododecanoic acid results in increased expression of ANGPTL4 mRNA
CTD
PMID:23567314
NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
G
Apoa2
apolipoprotein A2
affects expression
ISO
perfluorododecanoic acid affects the expression of APOA2 mRNA
CTD
PMID:23567314
NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355
G
Apoa4
apolipoprotein A4
affects expression
EXP
perfluorododecanoic acid affects the expression of APOA4 mRNA
CTD
PMID:22071372
NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
G
Ar
androgen receptor
affects expression
EXP
perfluorododecanoic acid affects the expression of AR mRNA
CTD
PMID:19397962
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
G
Arhgdib
Rho GDP dissociation inhibitor beta
increases expression
EXP
perfluorododecanoic acid results in increased expression of ARHGDIB protein
CTD
PMID:19854247
NCBI chr 4:169,822,951...169,841,884
Ensembl chr 4:169,822,952...169,841,658
G
Atf3
activating transcription factor 3
increases expression
ISO
perfluorododecanoic acid results in increased expression of ATF3 mRNA
CTD
PMID:23567314
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
G
Atp5pd
ATP synthase peripheral stalk subunit d
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of ATP5PD mRNA
CTD
PMID:19854247
NCBI chr10:100,657,700...100,662,960
Ensembl chr10:100,657,708...100,663,479
G
Baat
bile acid CoA:amino acid N-acyltransferase
decreases expression
ISO
perfluorododecanoic acid results in decreased expression of BAAT mRNA
CTD
PMID:23567314
NCBI chr 5:63,851,668...63,860,641
Ensembl chr 5:63,850,705...63,860,685
G
Bdh2
3-hydroxybutyrate dehydrogenase 2
decreases expression
ISO
perfluorododecanoic acid results in decreased expression of BDH2 mRNA
CTD
PMID:35337807
NCBI chr 2:223,702,410...223,723,076
Ensembl chr 2:223,702,412...223,723,072
G
Ccnd1
cyclin D1
increases expression
ISO
perfluorododecanoic acid results in increased expression of CCND1 mRNA
CTD
PMID:23567314
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
G
Cd36
CD36 molecule
increases expression increases uptake
EXP ISO
perfluorododecanoic acid results in increased expression of CD36 mRNA CD36 protein results in increased uptake of perfluorododecanoic acid
CTD
PMID:23353032 PMID:35380827
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
G
Cdh5
cadherin 5
affects expression
ISO
perfluorododecanoic acid affects the expression of CDH5 protein
CTD
PMID:33677611
NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368
G
Cops4
COP9 signalosome subunit 4
increases expression
EXP
perfluorododecanoic acid results in increased expression of COPS4 protein
CTD
PMID:26168851
NCBI chr14:9,078,579...9,108,788
Ensembl chr14:9,078,576...9,108,887
G
Cops8
COP9 signalosome subunit 8
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of COPS8 protein
CTD
PMID:19854247
NCBI chr 9:91,207,427...91,217,258
Ensembl chr 9:91,207,395...91,217,258
G
Cox5a
cytochrome c oxidase subunit 5A
decreases expression increases expression
EXP
perfluorododecanoic acid results in decreased expression of COX5A protein perfluorododecanoic acid results in increased expression of COX5A mRNA
CTD
PMID:19854247
NCBI chr 8:57,922,374...57,933,781
Ensembl chr 8:57,922,290...57,933,781
G
Cox5b
cytochrome c oxidase subunit 5B
increases expression
EXP
perfluorododecanoic acid results in increased expression of COX5B mRNA
CTD
PMID:19854247
NCBI chr 9:38,921,980...38,923,806
Ensembl chr 9:38,921,967...38,925,052
G
Cps1
carbamoyl-phosphate synthase 1
decreases expression multiple interactions
EXP
perfluorododecanoic acid results in decreased expression of CPS1 mRNA; perfluorododecanoic acid results in decreased expression of CPS1 protein PPARA mRNA inhibits the reaction [perfluorododecanoic acid results in decreased expression of CPS1 mRNA]
CTD
PMID:26168851
NCBI chr 9:68,614,153...68,737,037
Ensembl chr 9:68,614,153...68,737,033
G
Cpt1a
carnitine palmitoyltransferase 1A
affects expression
ISO
perfluorododecanoic acid affects the expression of CPT1A mRNA
CTD
PMID:23567314
NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
G
Crym
crystallin, mu
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of CRYM protein
CTD
PMID:26168851
NCBI chr 1:174,560,423...174,575,660
Ensembl chr 1:174,560,416...174,575,633
G
Csk
C-terminal Src kinase
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of CSK mRNA; perfluorododecanoic acid results in decreased expression of CSK protein
CTD
PMID:19854247
NCBI chr 8:58,029,748...58,048,742
Ensembl chr 8:58,029,749...58,048,292
G
Ctsa
cathepsin A
increases expression
EXP
perfluorododecanoic acid results in increased expression of CTSA protein
CTD
PMID:26168851
NCBI chr 3:153,569,106...153,574,983
Ensembl chr 3:153,568,381...153,576,215
G
Cuta
cutA divalent cation tolerance homolog
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of CUTA protein
CTD
PMID:19854247
NCBI chr20:5,022,956...5,024,580
Ensembl chr20:5,022,956...5,024,552
G
Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of CYP11A1 mRNA; perfluorododecanoic acid results in decreased expression of CYP11A1 protein
CTD
PMID:17400581 PMID:19397962 PMID:19429406 PMID:30489073 PMID:33774092
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
G
Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of CYP17A1 mRNA; perfluorododecanoic acid results in decreased expression of CYP17A1 protein
CTD
PMID:17400581 PMID:30489073 PMID:33774092
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases expression
ISO
perfluorododecanoic acid results in decreased expression of CYP1A1 mRNA
CTD
PMID:23567314
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
G
Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
decreases expression
ISO
perfluorododecanoic acid results in decreased expression of CYP2B10 mRNA
CTD
PMID:23567314
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
decreases expression
ISO
perfluorododecanoic acid results in decreased expression of CYP3A4 mRNA
CTD
PMID:23567314
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
G
Cyp4a1
cytochrome P450, family 4, subfamily a, polypeptide 1
multiple interactions increases expression
EXP
perfluorododecanoic acid inhibits the reaction [GW 6471 results in decreased expression of CYP4A1 mRNA]; perfluorododecanoic acid inhibits the reaction [pirinixic acid results in increased expression of CYP4A1 mRNA] perfluorododecanoic acid results in increased expression of CYP4A1 mRNA
CTD
PMID:26168851
NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
G
Cyp7a1
cytochrome P450 family 7 subfamily A member 1
decreases expression
ISO
perfluorododecanoic acid results in decreased expression of CYP7A1 mRNA
CTD
PMID:23567314
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
G
Ddah1
dimethylarginine dimethylaminohydrolase 1
increases expression
EXP
perfluorododecanoic acid results in increased expression of DDAH1 protein
CTD
PMID:26168851
NCBI chr 2:234,667,499...234,800,322
Ensembl chr 2:234,667,491...234,799,339
G
Ddit3
DNA-damage inducible transcript 3
increases expression
ISO
perfluorododecanoic acid results in increased expression of DDIT3 mRNA
CTD
PMID:23567314
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
G
Ddt
D-dopachrome tautomerase
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of DDT protein
CTD
PMID:19854247
NCBI chr20:12,884,216...12,886,687
Ensembl chr20:12,884,243...12,888,482
G
Dhh
desert hedgehog signaling molecule
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of DHH mRNA; perfluorododecanoic acid results in decreased expression of DHH protein
CTD
PMID:33774092
NCBI chr 7:130,050,910...130,056,406
Ensembl chr 7:130,050,910...130,056,406
G
Dlat
dihydrolipoamide S-acetyltransferase
increases expression
EXP
perfluorododecanoic acid results in increased expression of DLAT protein
CTD
PMID:26168851
NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479
G
Drd2
dopamine receptor D2
multiple interactions
ISO
[perfluoro-n-nonanoic acid co-treated with perfluorodecanoic acid co-treated with perfluoroundecanoic acid co-treated with perfluorododecanoic acid co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid] results in increased expression of DRD2 mRNA
CTD
PMID:34371090
NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
G
Ech1
enoyl-CoA hydratase 1
increases expression multiple interactions
EXP
perfluorododecanoic acid results in increased expression of ECH1 mRNA; perfluorododecanoic acid results in increased expression of ECH1 protein PPARA mRNA promotes the reaction [perfluorododecanoic acid results in increased expression of ECH1 mRNA]
CTD
PMID:26168851
NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
G
Efhd2
EF-hand domain family, member D2
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of EFHD2 protein
CTD
PMID:19854247
NCBI chr 5:154,160,945...154,176,980
Ensembl chr 5:154,160,946...154,176,980
G
Ehhadh
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
affects expression
ISO
perfluorododecanoic acid affects the expression of EHHADH mRNA
CTD
PMID:35337807
NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
G
Esr1
estrogen receptor 1
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of ESR1 mRNA
CTD
PMID:19429406
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
G
Esr2
estrogen receptor 2
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of ESR2 mRNA
CTD
PMID:19429406
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
G
Ethe1
ETHE1, persulfide dioxygenase
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of ETHE1 protein
CTD
PMID:26168851
NCBI chr 1:80,184,037...80,199,092
Ensembl chr 1:80,183,894...80,199,052
G
Fabp1
fatty acid binding protein 1
decreases expression
ISO
perfluorododecanoic acid results in decreased expression of FABP1 mRNA
CTD
PMID:23567314 PMID:35337807
NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
G
Fasn
fatty acid synthase
decreases expression affects expression
EXP ISO
perfluorododecanoic acid results in decreased expression of FASN mRNA perfluorododecanoic acid affects the expression of FASN mRNA
CTD
PMID:23353032 PMID:35337807
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
G
Fdft1
farnesyl diphosphate farnesyl transferase 1
increases expression
EXP
perfluorododecanoic acid results in increased expression of FDFT1 mRNA
CTD
PMID:22071372
NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
G
Fhit
fragile histidine triad diadenosine triphosphatase
increases expression
EXP
perfluorododecanoic acid results in increased expression of FHIT protein
CTD
PMID:19854247
NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340
G
Fshb
follicle stimulating hormone subunit beta
decreases expression decreases secretion
EXP
perfluorododecanoic acid results in decreased expression of FSHB mRNA; perfluorododecanoic acid results in decreased expression of FSHB protein perfluorododecanoic acid results in decreased secretion of FSHB protein
CTD
PMID:19397962 PMID:30489073 PMID:33774092
NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
G
Fshr
follicle stimulating hormone receptor
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of FSHR mRNA; perfluorododecanoic acid results in decreased expression of FSHR protein
CTD
PMID:33774092
NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785
G
Fth1
ferritin heavy chain 1
decreases expression increases expression
EXP
perfluorododecanoic acid results in decreased expression of FTH1 protein perfluorododecanoic acid results in increased expression of FTH1 mRNA
CTD
PMID:19854247
NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
G
Gadd45b
growth arrest and DNA-damage-inducible, beta
increases expression
ISO
perfluorododecanoic acid results in increased expression of GADD45B mRNA
CTD
PMID:23567314
NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
G
Gc
GC, vitamin D binding protein
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of GC protein
CTD
PMID:26168851
NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567
G
Gk
glycerol kinase
decreases expression
ISO
perfluorododecanoic acid results in decreased expression of GK mRNA
CTD
PMID:23567314
NCBI chr X:50,162,089...50,238,707
Ensembl chr X:50,163,123...50,238,631
G
Glod4
glyoxalase domain containing 4
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of GLOD4 protein
CTD
PMID:19854247
NCBI chr10:61,077,535...61,095,876
Ensembl chr10:61,066,421...61,095,898
G
Gmfb
glia maturation factor, beta
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of GMFB protein
CTD
PMID:26168851
NCBI chr15:20,069,923...20,081,005
Ensembl chr15:20,067,263...20,080,331
G
Gmfg
glia maturation factor, gamma
increases expression
EXP
perfluorododecanoic acid results in increased expression of GMFG protein
CTD
PMID:19854247
NCBI chr 1:83,728,797...83,739,189
Ensembl chr 1:83,728,776...83,739,183
G
Gnrhr
gonadotropin releasing hormone receptor
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of GNRHR mRNA
CTD
PMID:19397962
NCBI chr14:21,856,871...21,874,861
Ensembl chr14:21,856,871...21,874,861
G
Gpam
glycerol-3-phosphate acyltransferase, mitochondrial
increases expression
ISO
perfluorododecanoic acid results in increased expression of GPAM mRNA
CTD
PMID:35337807
NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
G
Gpd1
glycerol-3-phosphate dehydrogenase 1
increases expression
EXP
perfluorododecanoic acid results in increased expression of GPD1 protein
CTD
PMID:26168851
NCBI chr 7:130,842,526...130,851,530
Ensembl chr 7:130,844,138...130,851,529
G
Gsk3a
glycogen synthase kinase 3 alpha
decreases expression affects response to substance
EXP
perfluorododecanoic acid results in decreased expression of GSK3A protein; perfluorododecanoic acid results in decreased expression of GSK3A protein modified form GSK3A protein affects the susceptibility to perfluorododecanoic acid
CTD
PMID:23353032
NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802
G
Gsk3b
glycogen synthase kinase 3 beta
affects response to substance decreases expression
EXP
GSK3B protein affects the susceptibility to perfluorododecanoic acid perfluorododecanoic acid results in decreased expression of GSK3B protein; perfluorododecanoic acid results in decreased expression of GSK3B protein modified form
CTD
PMID:23353032
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
G
Gsta1
glutathione S-transferase alpha 1
decreases expression
ISO
perfluorododecanoic acid results in decreased expression of GSTA1 mRNA
CTD
PMID:35337807
NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
G
Haao
3-hydroxyanthranilate 3,4-dioxygenase
increases expression
EXP
perfluorododecanoic acid results in increased expression of HAAO protein
CTD
PMID:26168851
NCBI chr 6:10,845,235...10,864,863
Ensembl chr 6:10,845,771...10,864,877
G
Hadha
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
affects expression multiple interactions increases expression
ISO EXP
perfluorododecanoic acid affects the expression of HADHA mRNA PPARA mRNA promotes the reaction [perfluorododecanoic acid results in increased expression of HADHA mRNA] perfluorododecanoic acid results in increased expression of HADHA mRNA; perfluorododecanoic acid results in increased expression of HADHA protein
CTD
PMID:22071372 PMID:23567314 PMID:26168851
NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869
G
Hadhb
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
increases expression
EXP
perfluorododecanoic acid results in increased expression of HADHB mRNA
CTD
PMID:22071372
NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869
G
Hhex
hematopoietically expressed homeobox
increases expression
EXP
perfluorododecanoic acid results in increased expression of HHEX mRNA
CTD
PMID:22071372
NCBI chr 1:235,190,455...235,196,042
Ensembl chr 1:235,190,455...235,196,042
G
Hmgcs1
3-hydroxy-3-methylglutaryl-CoA synthase 1
affects expression
ISO
perfluorododecanoic acid affects the expression of HMGCS1 mRNA
CTD
PMID:35337807
NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
G
Hmgcs2
3-hydroxy-3-methylglutaryl-CoA synthase 2
decreases expression
ISO
perfluorododecanoic acid results in decreased expression of HMGCS2 mRNA
CTD
PMID:23567314
NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
G
Hmox1
heme oxygenase 1
increases expression
ISO
perfluorododecanoic acid results in increased expression of HMOX1 mRNA
CTD
PMID:23567314
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
G
Hpx
hemopexin
increases expression
EXP
perfluorododecanoic acid results in increased expression of HPX protein
CTD
PMID:26168851
NCBI chr 1:159,932,819...159,940,327
Ensembl chr 1:159,932,755...159,940,328
G
Hsd11b1
hydroxysteroid 11-beta dehydrogenase 1
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of HSD11B1 mRNA; perfluorododecanoic acid results in decreased expression of HSD11B1 protein
CTD
PMID:30489073 PMID:33774092
NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
G
Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
decreases activity
ISO
perfluorododecanoic acid results in decreased activity of HSD11B2 protein
CTD
PMID:36878351
NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
G
Hsd17b1
hydroxysteroid (17-beta) dehydrogenase 1
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of HSD17B1 mRNA
CTD
PMID:19429406
NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927
G
Hsd17b2
hydroxysteroid (17-beta) dehydrogenase 2
affects expression
EXP
perfluorododecanoic acid affects the expression of HSD17B2 mRNA
CTD
PMID:33774092
NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202
G
Hsd17b3
hydroxysteroid (17-beta) dehydrogenase 3
decreases expression affects expression
EXP
perfluorododecanoic acid results in decreased expression of HSD17B3 mRNA perfluorododecanoic acid affects the expression of HSD17B3 protein
CTD
PMID:17400581 PMID:33774092
NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554
G
Hsd3b1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
decreases expression decreases activity affects expression
EXP ISO
perfluorododecanoic acid results in decreased expression of HSD3B1 mRNA; perfluorododecanoic acid results in decreased expression of HSD3B1 protein perfluorododecanoic acid results in decreased activity of HSD3B1 protein perfluorododecanoic acid affects the expression of HSD3B1 mRNA; perfluorododecanoic acid affects the expression of HSD3B1 protein
CTD
PMID:17400581 PMID:33774092 PMID:36122607
NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
G
Hspa5
heat shock protein family A (Hsp70) member 5
affects expression
EXP
perfluorododecanoic acid affects the expression of HSPA5 protein
CTD
PMID:26168851
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
G
Hspa8
heat shock protein family A (Hsp70) member 8
increases expression
EXP
perfluorododecanoic acid results in increased expression of HSPA8 protein
CTD
PMID:26168851
NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
G
Hspa9
heat shock protein family A (Hsp70) member 9
increases expression
EXP
perfluorododecanoic acid results in increased expression of HSPA9 protein
CTD
PMID:26168851
NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
G
Hspd1
heat shock protein family D (Hsp60) member 1
increases expression
EXP
perfluorododecanoic acid results in increased expression of HSPD1 protein
CTD
PMID:26168851
NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
G
Idh3a
isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of IDH3A protein
CTD
PMID:26168851
NCBI chr 8:54,971,694...54,991,085
Ensembl chr 8:54,971,740...54,991,084
G
Ido1
indoleamine 2,3-dioxygenase 1
increases expression
EXP
perfluorododecanoic acid results in increased expression of IDO1 protein
CTD
PMID:19854247
NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730
G
Ift20
intraflagellar transport 20
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of IFT20 protein
CTD
PMID:19854247
NCBI chr10:63,432,597...63,438,125
Ensembl chr10:63,432,633...63,438,124
G
Igf1
insulin-like growth factor 1
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of IGF1 mRNA
CTD
PMID:19397962
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
G
Igf1r
insulin-like growth factor 1 receptor
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of IGF1R mRNA
CTD
PMID:19397962
NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777
G
Il1a
interleukin 1 alpha
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of IL1A mRNA
CTD
PMID:19397962
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
G
Impa1
inositol monophosphatase 1
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of IMPA1 protein
CTD
PMID:19854247
NCBI chr 2:91,462,781...91,484,057
Ensembl chr 2:91,462,799...91,484,313
G
Irs1
insulin receptor substrate 1
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of IRS1 protein modified form
CTD
PMID:23353032
NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
G
Itga1
integrin subunit alpha 1
affects expression
ISO
perfluorododecanoic acid affects the expression of ITGA1 protein
CTD
PMID:33677611
NCBI chr 2:46,646,125...46,812,237
Ensembl chr 2:46,653,193...46,812,238
G
Itpa
inosine triphosphatase
increases expression
EXP
perfluorododecanoic acid results in increased expression of ITPA protein
CTD
PMID:26168851
NCBI chr 3:117,885,464...117,897,247
Ensembl chr 3:117,885,099...117,897,249
G
Ivd
isovaleryl-CoA dehydrogenase
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of IVD protein
CTD
PMID:26168851
NCBI chr 3:105,851,710...105,872,144
Ensembl chr 3:105,851,683...105,872,575
G
Krt10
keratin 10
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of KRT10 protein
CTD
PMID:19854247
NCBI chr10:84,338,695...84,343,279
Ensembl chr10:84,338,706...84,343,701
G
Krt14
keratin 14
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of KRT14 protein
CTD
PMID:19854247
NCBI chr10:85,137,786...85,142,054
Ensembl chr10:85,066,802...85,171,799
G
Krt16
keratin 16
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of KRT16 protein
CTD
PMID:19854247
NCBI chr10:85,168,357...85,171,816
Ensembl chr10:85,066,802...85,171,799
G
Krt8
keratin 8
increases expression
EXP
perfluorododecanoic acid results in increased expression of KRT8 protein
CTD
PMID:26168851
NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728
G
Lhb
luteinizing hormone subunit beta
decreases expression decreases secretion
EXP
perfluorododecanoic acid results in decreased expression of LHB mRNA; perfluorododecanoic acid results in decreased expression of LHB protein perfluorododecanoic acid results in decreased secretion of LHB protein
CTD
PMID:17400581 PMID:19397962 PMID:30489073 PMID:33774092
NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
G
Lhcgr
luteinizing hormone/choriogonadotropin receptor
decreases expression affects expression
EXP
perfluorododecanoic acid results in decreased expression of LHCGR mRNA; perfluorododecanoic acid results in decreased expression of LHCGR protein perfluorododecanoic acid affects the expression of LHCGR mRNA; perfluorododecanoic acid affects the expression of LHCGR protein
CTD
PMID:19429406 PMID:30489073 PMID:33774092
NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521
G
Lhpp
phospholysine phosphohistidine inorganic pyrophosphate phosphatase
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of LHPP protein
CTD
PMID:26168851
NCBI chr 1:187,403,390...187,494,577
Ensembl chr 1:187,403,433...187,494,578
G
Mbl2
mannose binding lectin 2
decreases expression
ISO
perfluorododecanoic acid results in decreased expression of MBL2 mRNA
CTD
PMID:23567314
NCBI chr 1:228,016,439...228,024,736
G
Mdh1
malate dehydrogenase 1
increases expression
EXP
perfluorododecanoic acid results in increased expression of MDH1 protein
CTD
PMID:26168851
NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925
G
Mttp
microsomal triglyceride transfer protein
affects expression
ISO
perfluorododecanoic acid affects the expression of MTTP mRNA
CTD
PMID:35337807
NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
G
Mug2
murinoglobulin 2
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of PZP protein
CTD
PMID:26168851
NCBI chr 4:155,164,061...155,236,894
Ensembl chr 4:155,164,011...155,236,475
G
Ndufv2
NADH:ubiquinone oxidoreductase core subunit V2
increases expression
EXP
perfluorododecanoic acid results in increased expression of NDUFV2 protein
CTD
PMID:26168851
NCBI chr 9:105,690,454...105,710,669
Ensembl chr 9:105,690,455...105,710,713
G
Nos2
nitric oxide synthase 2
increases expression
ISO
perfluorododecanoic acid results in increased expression of NOS2 mRNA
CTD
PMID:23567314
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
G
Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases activity
ISO
perfluorododecanoic acid results in increased activity of NR1I2 protein
CTD
PMID:28115241
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
G
Nr1i3
nuclear receptor subfamily 1, group I, member 3
affects expression
ISO
perfluorododecanoic acid affects the expression of NR1I3 mRNA
CTD
PMID:35337807
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
G
Ntan1
N-terminal asparagine amidase
increases expression
EXP
perfluorododecanoic acid results in increased expression of NTAN1 protein
CTD
PMID:19854247
NCBI chr10:2,111,090...2,126,119
G
P4hb
prolyl 4-hydroxylase subunit beta
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of P4HB protein
CTD
PMID:26168851
NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500
G
Park7
Parkinsonism associated deglycase
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of PARK7 protein
CTD
PMID:19854247
NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
G
Pax8
paired box 8
increases expression
EXP
perfluorododecanoic acid results in increased expression of PAX8 mRNA
CTD
PMID:22071372
NCBI chr 3:7,185,721...7,242,363
Ensembl chr 3:7,185,723...7,242,363
G
Pbld1
phenazine biosynthesis-like protein domain containing 1
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of PBLD1 protein
CTD
PMID:26168851
NCBI chr20:25,551,274...25,566,543
Ensembl chr20:25,551,275...25,565,614
G
Pck2
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
increases expression
ISO
perfluorododecanoic acid results in increased expression of PCK2 mRNA
CTD
PMID:35337807
NCBI chr15:29,027,891...29,036,729
Ensembl chr15:29,027,894...29,037,283
G
Pdhb
pyruvate dehydrogenase E1 subunit beta
increases expression
EXP
perfluorododecanoic acid results in increased expression of PDHB protein
CTD
PMID:26168851
NCBI chr15:16,752,561...16,758,503
Ensembl chr15:16,750,980...16,758,500
G
Pdia6
protein disulfide isomerase family A, member 6
affects expression
EXP
perfluorododecanoic acid affects the expression of PDIA6 protein
CTD
PMID:26168851
NCBI chr 6:40,062,980...40,080,223
Ensembl chr 6:40,062,926...40,080,613
G
Pdk4
pyruvate dehydrogenase kinase 4
increases expression
ISO
perfluorododecanoic acid results in increased expression of PDK4 mRNA
CTD
PMID:23567314
NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
G
Pdpk1
3-phosphoinositide dependent protein kinase-1
decreases activity decreases expression
EXP
perfluorododecanoic acid results in decreased activity of PDPK1 protein perfluorododecanoic acid results in decreased expression of PDPK1 protein; perfluorododecanoic acid results in decreased expression of PDPK1 protein modified form
CTD
PMID:23353032
NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623
G
Pebp1
phosphatidylethanolamine binding protein 1
decreases expression increases expression
EXP
perfluorododecanoic acid results in decreased expression of PEBP1 protein perfluorododecanoic acid results in increased expression of PEBP1 mRNA
CTD
PMID:19854247
NCBI chr12:39,302,864...39,307,064
Ensembl chr12:39,302,840...39,307,862
G
Phb1
prohibitin 1
increases expression
EXP
perfluorododecanoic acid results in increased expression of PHB1 protein
CTD
PMID:26168851
NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042
G
Pitpna
phosphatidylinositol transfer protein, alpha
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of PITPNA protein
CTD
PMID:19854247
NCBI chr10:60,430,712...60,473,564
Ensembl chr10:60,430,748...60,471,342
G
Plin2
perilipin 2
increases expression affects expression
ISO
perfluorododecanoic acid results in increased expression of PLIN2 mRNA perfluorododecanoic acid affects the expression of PLIN2 mRNA
CTD
PMID:23567314
NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319
G
Por
cytochrome p450 oxidoreductase
increases expression
ISO
perfluorododecanoic acid results in increased expression of POR mRNA
CTD
PMID:23567314
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
G
Ppara
peroxisome proliferator activated receptor alpha
increases activity increases expression increases response to substance multiple interactions
ISO EXP
perfluorododecanoic acid results in increased activity of PPARA protein perfluorododecanoic acid results in increased expression of PPARA mRNA PPARA mRNA results in increased susceptibility to perfluorododecanoic acid perfluorododecanoic acid results in increased expression of PPARA mRNA; perfluorododecanoic acid results in increased expression of PPARA protein perfluorododecanoic acid inhibits the reaction [GW 6471 results in decreased expression of PPARA mRNA]; perfluorododecanoic acid inhibits the reaction [pirinixic acid results in increased expression of PPARA mRNA]; PPARA mRNA inhibits the reaction [perfluorododecanoic acid results in decreased expression of CPS1 mRNA]; PPARA mRNA inhibits the reaction [perfluorododecanoic acid results in increased abundance of Reactive Oxygen Species]; PPARA mRNA promotes the reaction [perfluorododecanoic acid results in decreased expression of ALDH2 protein]; PPARA mRNA promotes the reaction [perfluorododecanoic acid results in increased expression of ACOT1 mRNA]; PPARA mRNA promotes the reaction [perfluorododecanoic acid results in increased expression of ACOT2 mRNA]; PPARA mRNA promotes the reaction [perfluorododecanoic acid results in increased expression of ECH1 mRNA]; PPARA mRNA promotes the reaction [perfluorododecanoic acid results in increased expression of HADHA mRNA]
CTD
PMID:22107727 PMID:26168851 PMID:28857218 PMID:35337807
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
G
Ppard
peroxisome proliferator-activated receptor delta
increases expression
ISO
perfluorododecanoic acid results in increased expression of PPARD mRNA
CTD
PMID:23567314
NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
G
Pparg
peroxisome proliferator-activated receptor gamma
increases activity increases expression
ISO
perfluorododecanoic acid results in increased activity of PPARG protein perfluorododecanoic acid results in increased expression of PPARG mRNA
CTD
PMID:23391484 PMID:24998974 PMID:35337807
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
G
Ppargc1a
PPARG coactivator 1 alpha
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of PPARGC1A protein
CTD
PMID:30489073
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
G
Prdx2
peroxiredoxin 2
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of PRDX2 protein
CTD
PMID:26168851
NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194
G
Prdx4
peroxiredoxin 4
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of PRDX4 protein
CTD
PMID:26168851
NCBI chr X:40,026,762...40,044,066
Ensembl chr X:40,026,651...40,044,066
G
Psmf1
proteasome inhibitor subunit 1
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of PSMF1 protein
CTD
PMID:19854247
NCBI chr 3:140,235,371...140,260,546
Ensembl chr 3:140,235,373...140,260,546
G
Ptpn11
protein tyrosine phosphatase, non-receptor type 11
multiple interactions
ISO
perfluorododecanoic acid binds to and results in decreased activity of PTPN11 protein
CTD
PMID:27572461
NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925
G
Ranbp1
RAN binding protein 1
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of RANBP1 protein
CTD
PMID:19854247
NCBI chr11:82,742,603...82,750,836
Ensembl chr11:82,742,600...82,750,838
G
Rbp4
retinol binding protein 4
increases expression
EXP
perfluorododecanoic acid results in increased expression of RBP4 protein
CTD
PMID:26168851
NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399
G
Rgn
regucalcin
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of RGN protein
CTD
PMID:26168851
NCBI chr X:1,619,030...1,634,456
Ensembl chr X:1,619,032...1,634,450
G
Scarb1
scavenger receptor class B, member 1
decreases expression affects expression
EXP
perfluorododecanoic acid results in decreased expression of SCARB1 mRNA; perfluorododecanoic acid results in decreased expression of SCARB1 protein perfluorododecanoic acid affects the expression of SCARB1 mRNA; perfluorododecanoic acid affects the expression of SCARB1 protein
CTD
PMID:17400581 PMID:30489073 PMID:33774092
NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
G
Scd
stearoyl-CoA desaturase
decreases expression increases expression
ISO EXP
perfluorododecanoic acid results in decreased expression of SCD mRNA perfluorododecanoic acid results in increased expression of SCD1 mRNA
CTD
PMID:23353032 PMID:23567314 PMID:35337807
NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
G
Serpind1
serpin family D member 1
decreases expression
ISO
perfluorododecanoic acid results in decreased expression of SERPIND1 mRNA
CTD
PMID:23567314
NCBI chr11:83,664,517...83,675,593
Ensembl chr11:83,664,518...83,675,519
G
Serpinf2
serpin family F member 2
decreases expression
ISO
perfluorododecanoic acid results in decreased expression of SERPINF2 mRNA
CTD
PMID:23567314
NCBI chr10:60,272,400...60,280,506
Ensembl chr10:60,272,400...60,281,243
G
Sirt1
sirtuin 1
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of SIRT1 protein
CTD
PMID:30489073
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
G
Slc25a20
solute carrier family 25 member 20
decreases expression
ISO
perfluorododecanoic acid results in decreased expression of SLC25A20 mRNA
CTD
PMID:23567314
NCBI chr 8:109,365,056...109,386,512
Ensembl chr 8:109,365,002...109,386,512
G
Slc27a1
solute carrier family 27 member 1
increases expression
ISO
perfluorododecanoic acid results in increased expression of SLC27A1 mRNA
CTD
PMID:23567314
NCBI chr16:18,278,984...18,300,173
Ensembl chr16:18,278,984...18,296,063
G
Sod1
superoxide dismutase 1
decreases expression affects expression
EXP ISO
perfluorododecanoic acid results in decreased expression of SOD1 mRNA perfluorododecanoic acid affects the expression of SOD1 mRNA
CTD
PMID:19854247 PMID:35337807
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
G
Sox9
SRY-box transcription factor 9
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of SOX9 mRNA; perfluorododecanoic acid results in decreased expression of SOX9 protein
CTD
PMID:33774092
NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994
G
Srd5a1
steroid 5 alpha-reductase 1
affects expression decreases activity
EXP ISO
perfluorododecanoic acid affects the expression of SRD5A1 mRNA perfluorododecanoic acid results in decreased activity of SRD5A1 protein
CTD
PMID:33774092 PMID:38574835
NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461
G
Srebf1
sterol regulatory element binding transcription factor 1
increases expression
EXP ISO
perfluorododecanoic acid results in increased expression of SREBF1 mRNA
CTD
PMID:23353032 PMID:35337807
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
G
Star
steroidogenic acute regulatory protein
multiple interactions affects expression decreases expression
ISO EXP
Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [perfluorododecanoic acid inhibits the reaction [Cyclic AMP results in increased expression of STAR mRNA]]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [perfluorododecanoic acid inhibits the reaction [Cyclic AMP results in increased expression of STAR protein]]; perfluorododecanoic acid inhibits the reaction [Cyclic AMP results in increased expression of STAR mRNA]; perfluorododecanoic acid inhibits the reaction [Cyclic AMP results in increased expression of STAR protein] perfluorododecanoic acid affects the expression of STAR mRNA; perfluorododecanoic acid affects the expression of STAR protein perfluorododecanoic acid results in decreased expression of STAR mRNA; perfluorododecanoic acid results in decreased expression of STAR protein
CTD
PMID:17400581 PMID:19397962 PMID:19429406 PMID:20100736 PMID:30489073 PMID:33774092 More...
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
G
Stmn1
stathmin 1
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of STMN1 protein
CTD
PMID:19854247
NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
G
Suclg2
succinate-CoA ligase GDP-forming subunit beta
increases expression
EXP
perfluorododecanoic acid results in increased expression of SUCLG2 protein
CTD
PMID:26168851
NCBI chr 4:128,067,031...128,337,146
Ensembl chr 4:128,067,033...128,337,170
G
Sult1c3
sulfotransferase family 1C member 3
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of SULT1C3 protein
CTD
PMID:26168851
NCBI chr 9:7,221,580...7,266,991
Ensembl chr 9:7,221,578...7,267,030
G
Sult2a1
sulfotransferase family 2A member 1
affects expression
ISO
perfluorododecanoic acid affects the expression of SULT2A1 mRNA
CTD
PMID:35337807
NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134
G
Suox
sulfite oxidase
increases expression
EXP
perfluorododecanoic acid results in increased expression of SUOX protein
CTD
PMID:26168851
NCBI chr 7:1,103,149...1,107,156
Ensembl chr 7:1,103,151...1,107,038
G
Th
tyrosine hydroxylase
multiple interactions
ISO
[perfluoro-n-nonanoic acid co-treated with perfluorodecanoic acid co-treated with perfluoroundecanoic acid co-treated with perfluorododecanoic acid co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid] results in decreased expression of TH mRNA
CTD
PMID:34371090
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
G
Thra
thyroid hormone receptor alpha
affects binding
ISO
perfluorododecanoic acid binds to THRA protein
CTD
PMID:24819616
NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
G
Tpm1
tropomyosin 1
increases expression
EXP
perfluorododecanoic acid results in increased expression of TPM1 protein
CTD
PMID:26168851
NCBI chr 8:67,635,479...67,662,330
Ensembl chr 8:67,635,479...67,662,802
G
Trap1
TNF receptor-associated protein 1
increases expression
EXP
perfluorododecanoic acid results in increased expression of TRAP1 protein
CTD
PMID:26168851
NCBI chr10:11,464,882...11,498,931
Ensembl chr10:11,464,821...11,498,981
G
Ttr
transthyretin
multiple interactions
ISO
perfluorododecanoic acid affects the reaction [Thyroxine binds to TTR protein]
CTD
PMID:27528273
NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008
G
Txnip
thioredoxin interacting protein
affects expression
ISO
perfluorododecanoic acid affects the expression of TXNIP mRNA
CTD
PMID:23567314
NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
G
Ube2n
ubiquitin-conjugating enzyme E2N
decreases expression
EXP
perfluorododecanoic acid results in decreased expression of UBE2N protein
CTD
PMID:19854247
NCBI chr 7:30,154,330...30,184,373
Ensembl chr 7:30,154,616...30,184,355
G
Ugt1a1
UDP glucuronosyltransferase family 1 member A1
decreases expression
ISO
perfluorododecanoic acid results in decreased expression of UGT1A1 mRNA
CTD
PMID:35337807
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Uqcrc1
ubiquinol-cytochrome c reductase core protein 1
increases expression
EXP
perfluorododecanoic acid results in increased expression of UQCRC1 protein
CTD
PMID:26168851
NCBI chr 8:109,589,735...109,601,481
Ensembl chr 8:109,589,706...109,601,480
G
Uqcrh
ubiquinol-cytochrome c reductase hinge protein
decreases expression increases expression
EXP
perfluorododecanoic acid results in decreased expression of UQCRH protein perfluorododecanoic acid results in increased expression of UQCRH mRNA
CTD
PMID:19854247
NCBI chr 5:129,545,978...129,554,173
Ensembl chr 5:129,545,984...129,554,242
G
Ywhae
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
decreases expression increases expression
EXP
perfluorododecanoic acid results in decreased expression of YWHAE protein perfluorododecanoic acid results in increased expression of YWHAE mRNA
CTD
PMID:19854247
NCBI chr10:60,584,665...60,622,352
Ensembl chr10:60,584,652...60,671,589
G
Iyd
iodotyrosine deiodinase
multiple interactions
ISO
1-monomyristin inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine]
CTD
PMID:33352258
NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all