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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(aminomethyl)phosphonic acid
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Accession:CHEBI:28812 term browser browse the term
Definition:A member of the class of phosphonic acids that is phosphonic acid substituted by an aminomethyl group. It is a metabolite of the herbicide glyphosate.
Synonyms:related_synonym: 1-Aminomethylphosphonic acid;   AMPA;   Formula=CH6NO3P;   InChI=1S/CH6NO3P/c2-1-6(3,4)5/h1-2H2,(H2,3,4,5);   InChIKey=MGRVRXRGTBOSHW-UHFFFAOYSA-N;   SMILES=NCP(O)(O)=O
 alt_id: CHEBI:22515;   CHEBI:2358
 xref: Beilstein:1701219;   CAS:1066-51-9;   DrugBank:DB02057;   Gmelin:793599;   KEGG:C11033
 xref_mesh: MESH:C036423
 xref: MetaCyc:CPD0-1074;   PMID:15291487;   PMID:15950343;   Reaxys:1701219;   UM-BBD_compID:c0136;   Wikipedia:Aminomethylphosphonic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:133674


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(aminomethyl)phosphonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO [1-aminomethylphosphonic acid co-treated with methoxyacetic acid] results in decreased expression of BIRC2 protein CTD PMID:26006246 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO [1-aminomethylphosphonic acid co-treated with methoxyacetic acid] results in decreased expression of BIRC3 protein CTD PMID:26006246 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO 1-aminomethylphosphonic acid results in increased activity of CASP3 protein
[1-aminomethylphosphonic acid co-treated with methoxyacetic acid] results in increased cleavage of and results in increased activity of CASP3 protein
CTD PMID:23983455 PMID:26006246 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO [1-aminomethylphosphonic acid co-treated with methoxyacetic acid] results in increased cleavage of and results in increased activity of CASP7 protein CTD PMID:26006246 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
ISO [1-aminomethylphosphonic acid co-treated with methoxyacetic acid] results in increased expression of CASP9 protein
1-aminomethylphosphonic acid results in increased expression of CASP9 protein
CTD PMID:23983455 PMID:26006246 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccnd3 cyclin D3 multiple interactions
decreases expression
ISO [1-aminomethylphosphonic acid co-treated with methoxyacetic acid] results in decreased expression of CCND3 protein
1-aminomethylphosphonic acid results in decreased expression of CCND3 protein
CTD PMID:23983455 PMID:26006246 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO 1-aminomethylphosphonic acid results in increased expression of CDKN1A protein
[1-aminomethylphosphonic acid co-treated with methoxyacetic acid] results in increased expression of CDKN1A protein
CTD PMID:23983455 PMID:26006246 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO 1-aminomethylphosphonic acid results in increased cleavage of PARP1 protein
[1-aminomethylphosphonic acid co-treated with methoxyacetic acid] results in increased cleavage of PARP1 protein
CTD PMID:23983455 PMID:26006246 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Tp53 tumor protein p53 increases expression ISO 1-aminomethylphosphonic acid results in increased expression of TP53 protein CTD PMID:23983455 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19792
      application 19465
        pesticide 16525
          fungicide 10730
            phosphonic acid 3110
              (aminomethyl)phosphonic acid 9
                (acetamidomethyl)phosphonic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      chalcogen 19425
                        oxygen atom 19387
                          oxygen molecular entity 19387
                            hydroxides 19113
                              oxoacid 18243
                                pnictogen oxoacid 10293
                                  phosphorus oxoacid 9214
                                    phosphonic acid 3110
                                      (aminomethyl)phosphonic acid 9
                                        (acetamidomethyl)phosphonic acid 0
paths to the root