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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:serotonin
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Accession:CHEBI:28790 term browser browse the term
Definition:A primary amino compound that is the 5-hydroxy derivative of tryptamine.
Synonyms:related_synonym: 3-(2-Aminoethyl)-1H-indol-5-ol;   5-HT;   5-Hydroxytryptamine;   Enteramine;   Formula=C10H12N2O;   InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2;   InChIKey=QZAYGJVTTNCVMB-UHFFFAOYSA-N;   SMILES=C1=CC(=CC=2C(=CNC12)CCN)O;   serotonine;   thrombocytin;   thrombotonin
 alt_id: CHEBI:1420;   CHEBI:26652;   CHEBI:49894
 xref: Beilstein:143524;   CAS:50-67-9;   Gmelin:1861995;   HMDB:HMDB0000259;   KEGG:C00780;   KNApSAcK:C00001429;   LINCS:LSM-6589
 xref_mesh: MESH:D012701
 xref: MetaCyc:SEROTONIN;   PDBeChem:SRO;   PMID:18593914;   PMID:22770225;   PMID:24136337;   Reaxys:143524;   Wikipedia:Serotonin
 cyclic_relationship: is_conjugate_base_of CHEBI:350546

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serotonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions		 EXP Serotonin results in increased expression of FOS mRNA; Serotonin results in increased expression of FOS protein
sarpogrelate inhibits the reaction [Serotonin results in increased expression of FOS mRNA]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of FOS protein]		 CTD PMID:11426759 NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 EXP sarpogrelate inhibits the reaction [Serotonin results in increased expression of JUN mRNA]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of JUN protein]
Serotonin results in increased expression of JUN mRNA; Serotonin results in increased expression of JUN protein		 CTD PMID:11426759 NCBI chr 6:153,686,425...153,687,635 JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions		 EXP Serotonin results in increased phosphorylation of MAPK1 protein
sarpogrelate inhibits the reaction [Serotonin results in increased phosphorylation of MAPK1 protein]		 CTD PMID:11426759 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation		 EXP sarpogrelate inhibits the reaction [Serotonin results in increased phosphorylation of MAPK3 protein] CTD PMID:11426759 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 875
    role 855
      biological role 855
        molecular messenger 218
          monoamine molecular messenger 7
            serotonin 4
              1-(5-methoxy-1H-indol-3-yl)-2-propanamine 0
              1-[5-(thiophen-2-ylmethoxy)-1H-indol-3-yl]-2-propanamine 0
              2,2,2-trideuterio-N-[1,1,2,2-tetradeuterio-2-(5-hydroxy-1H-indol-3-yl)ethyl]acetamide 0
              2-methylserotonin 0
              3-(2-aminoethyl)-6-methoxy-1H-indol-5-ol 2-amino-3-methyl-4H-imidazol-5-one 0
              3-(2-aminoethyl)-7-methoxy-1H-indol-5-ol 2-amino-3-methyl-4H-imidazol-5-one 0
              5-Methoxy DL-tryptophan 0
              5-nonyloxytryptamine 0
              Creatinine sulfate mixture with serotonin 0
              N,O-dimethylserotonin 0
              N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-L-glutamine residue 0
              N-acylserotonin + 0
              N-arachidonoyl-2-oxoserotonin 0
              N-methylserotonin 0
              O-methylserotonin + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 875
    subatomic particle 860
      composite particle 860
        hadron 860
          baryon 860
            nucleon 860
              atomic nucleus 860
                atom 860
                  main group element atom 850
                    p-block element atom 847
                      carbon group element atom 823
                        carbon atom 822
                          organic molecular entity 822
                            organic molecule 735
                              organic cyclic compound 645
                                organic heterocyclic compound 361
                                  organic heteropolycyclic compound 252
                                    organic heterobicyclic compound 100
                                      benzopyrrole 23
                                        indoles 23
                                          tryptamines 12
                                            tryptamine 12
                                              serotonin 4
                                                1-(5-methoxy-1H-indol-3-yl)-2-propanamine 0
                                                1-[5-(thiophen-2-ylmethoxy)-1H-indol-3-yl]-2-propanamine 0
                                                2,2,2-trideuterio-N-[1,1,2,2-tetradeuterio-2-(5-hydroxy-1H-indol-3-yl)ethyl]acetamide 0
                                                2-methylserotonin 0
                                                3-(2-aminoethyl)-6-methoxy-1H-indol-5-ol 2-amino-3-methyl-4H-imidazol-5-one 0
                                                3-(2-aminoethyl)-7-methoxy-1H-indol-5-ol 2-amino-3-methyl-4H-imidazol-5-one 0
                                                5-Methoxy DL-tryptophan 0
                                                5-nonyloxytryptamine 0
                                                Creatinine sulfate mixture with serotonin 0
                                                N,O-dimethylserotonin 0
                                                N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-L-glutamine residue 0
                                                N-acylserotonin + 0
                                                N-arachidonoyl-2-oxoserotonin 0
                                                N-methylserotonin 0
                                                O-methylserotonin + 0
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