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G |
Acat1 |
acetyl-CoA acetyltransferase 1 |
multiple interactions increases expression |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; AG 1879 inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; guanosine 5'-O-(2-thiodiphosphate) inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; rottlerin inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; sarpogrelate metabolite inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; Serotonin results in increased expression of and results in increased activity of ACAT1 protein Serotonin results in increased expression of ACAT1 mRNA alternative form |
CTD |
PMID:16157345 |
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NCBI chr 8:62,876,003...62,905,080
Ensembl chr 8:53,979,813...54,008,855
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G |
Ache |
acetylcholinesterase |
multiple interactions |
ISO |
Serotonin analog inhibits the reaction [Scopolamine results in increased activity of ACHE protein] |
CTD |
PMID:26408985 |
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NCBI chr12:25,042,882...25,050,608
Ensembl chr12:19,407,360...19,413,651
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G |
Akt1 |
AKT serine/threonine kinase 1 |
increases activity multiple interactions |
ISO |
Serotonin results in increased activity of AKT1 protein [[Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]] which results in increased ubiquitination of and results in increased degradation of IRS1 protein; [Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]; [sarpogrelate results in increased activity of AKT1 protein] inhibits the reaction [Serotonin results in increased ubiquitination of and results in increased degradation of IRS1 protein]; Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein] |
CTD |
PMID:22975078 |
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NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
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G |
App |
amyloid beta precursor protein |
increases response to substance multiple interactions |
ISO |
APP protein modified form results in increased susceptibility to Serotonin Oils, Volatile inhibits the reaction [[APP protein modified form binds to APP protein modified form] which results in increased susceptibility to Serotonin]; Ursolic Acid inhibits the reaction [APP protein modified form results in increased susceptibility to Serotonin] |
CTD |
PMID:28915354 PMID:34902447 |
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NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561
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G |
Aqp3 |
aquaporin 3 (Gill blood group) |
multiple interactions increases expression |
ISO EXP |
[Serotonin results in increased localization of and results in increased activity of PPARG protein] which results in increased expression of AQP3 mRNA; Fluoxetine inhibits the reaction [Serotonin results in increased expression of AQP3 mRNA] Fluoxetine inhibits the reaction [Serotonin results in increased expression of AQP3 protein] |
CTD |
PMID:25766885 |
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NCBI chr 5:61,035,165...61,040,683
Ensembl chr 5:56,239,201...56,244,720
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G |
Bdnf |
brain-derived neurotrophic factor |
multiple interactions |
EXP ISO |
[Butyrates co-treated with Serotonin] results in increased expression of BDNF mRNA; [trichostatin A co-treated with Serotonin] results in increased expression of BDNF mRNA; [Valproic Acid co-treated with Serotonin] results in increased expression of BDNF mRNA Serotonin analog inhibits the reaction [Scopolamine results in decreased expression of BDNF protein] |
CTD |
PMID:19360904 PMID:26408985 |
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NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615
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G |
Calca |
calcitonin-related polypeptide alpha |
multiple interactions increases secretion |
EXP |
[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein; [KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein; Dinoprostone inhibits the reaction [Flurbiprofen inhibits the reaction [Serotonin results in increased secretion of CALCA protein]]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]]; Flurbiprofen inhibits the reaction [Serotonin results in increased secretion of CALCA protein]; Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein] |
CTD |
PMID:11166334 PMID:12791437 PMID:14991081 |
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NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:168,878,214...168,883,105
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
Serotonin inhibits the reaction [7-ketocholesterol results in increased activity of CASP3 protein] |
CTD |
PMID:24650663 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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G |
Casp7 |
caspase 7 |
multiple interactions |
ISO |
Serotonin inhibits the reaction [7-ketocholesterol results in increased activity of CASP7 protein] |
CTD |
PMID:24650663 |
|
NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729
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G |
Cat |
catalase |
multiple interactions |
ISO |
CAT protein inhibits the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in decreased abundance of Serotonin] |
CTD |
PMID:11435997 |
|
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
increases expression |
EXP |
Serotonin results in increased expression of CCL5 protein |
CTD |
PMID:38701902 |
|
NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377
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G |
Cftr |
CF transmembrane conductance regulator |
multiple interactions increases activity |
ISO |
Serotonin promotes the reaction [Isoproterenol results in increased activity of CFTR protein] Serotonin results in increased activity of CFTR protein |
CTD |
PMID:15151902 |
|
NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:46,560,885...46,728,756
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G |
Chat |
choline O-acetyltransferase |
multiple interactions |
ISO |
Serotonin analog inhibits the reaction [Scopolamine results in decreased activity of CHAT protein] |
CTD |
PMID:26408985 |
|
NCBI chr16:7,663,665...7,723,416
Ensembl chr16:7,657,362...7,717,093
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G |
Cnr1 |
cannabinoid receptor 1 |
multiple interactions |
ISO |
Serotonin inhibits the reaction [Dextran Sulfate results in increased expression of CNR1 protein] |
CTD |
PMID:30611738 |
|
NCBI chr 5:53,204,867...53,230,396
Ensembl chr 5:48,408,574...48,435,099
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G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
ISO |
Serotonin analog inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein] |
CTD |
PMID:26408985 |
|
NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816
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G |
Crh |
corticotropin releasing hormone |
multiple interactions increases secretion |
EXP |
8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [CRH protein results in increased secretion of Serotonin]; corticotropin releasing hormone (9-41) inhibits the reaction [CRH protein results in increased secretion of Serotonin] |
CTD |
PMID:14575894 |
|
NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:102,143,055...102,144,919
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G |
Dbh |
dopamine beta-hydroxylase |
multiple interactions |
ISO |
DBH protein promotes the reaction [Citalopram results in increased abundance of Serotonin]; DBH protein promotes the reaction [Fluoxetine results in increased abundance of Serotonin] |
CTD |
PMID:15148402 |
|
NCBI chr 3:30,886,313...30,903,313
Ensembl chr 3:10,488,260...10,505,248
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G |
Ddc |
dopa decarboxylase |
multiple interactions |
EXP |
[DDC protein results in decreased carboxylation of 5-Hydroxytryptophan] which results in increased chemical synthesis of Serotonin |
CTD |
PMID:32243540 |
|
NCBI chr14:90,592,304...90,682,830
Ensembl chr14:86,378,685...86,469,208
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G |
Drd1 |
dopamine receptor D1 |
multiple interactions |
EXP |
Serotonin inhibits the reaction [Rotenone results in decreased expression of DRD1 mRNA]; Serotonin inhibits the reaction [Rotenone results in decreased expression of DRD1 protein] |
CTD |
PMID:20887679 |
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NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,540,558...10,545,002
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G |
Drd2 |
dopamine receptor D2 |
multiple interactions |
EXP |
Serotonin inhibits the reaction [Rotenone results in increased expression of DRD2 mRNA]; Serotonin inhibits the reaction [Rotenone results in increased expression of DRD2 protein] |
CTD |
PMID:20887679 |
|
NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:49,708,927...49,772,875
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G |
En2 |
engrailed homeobox 2 |
affects abundance |
ISO |
EN2 protein affects the abundance of Serotonin; EN2 protein affects the abundance of Serotonin metabolite |
CTD |
PMID:16935268 |
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NCBI chr 4:7,954,953...7,960,793
Ensembl chr 4:7,221,096...7,226,943
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G |
Enam |
enamelin |
decreases expression |
ISO |
Serotonin results in decreased expression of ENAM mRNA |
CTD |
PMID:21083617 |
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NCBI chr14:19,840,773...19,865,476
Ensembl chr14:19,556,729...19,581,425
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G |
Faah |
fatty acid amide hydrolase |
multiple interactions |
ISO |
[Serotonin co-treated with Dextran Sulfate] results in decreased expression of FAAH protein |
CTD |
PMID:30611738 |
|
NCBI chr 5:134,716,545...134,735,396
Ensembl chr 5:129,479,824...129,498,677
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G |
Fgf1 |
fibroblast growth factor 1 |
increases expression |
EXP |
Serotonin results in increased expression of FGF1 protein |
CTD |
PMID:15264218 |
|
NCBI chr18:30,937,670...31,023,786
Ensembl chr18:30,686,581...30,772,357
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G |
Fgf5 |
fibroblast growth factor 5 |
affects uptake |
EXP |
FGF5 protein affects the uptake of Serotonin |
CTD |
PMID:8167846 |
|
NCBI chr14:11,323,827...11,346,164
Ensembl chr14:11,325,334...11,345,997
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression |
EXP |
Serotonin results in increased expression of FOS mRNA |
CTD |
PMID:10700011 |
|
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036
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G |
Gapdh |
glyceraldehyde-3-phosphate dehydrogenase |
multiple interactions |
ISO |
[MPO protein co-treated with XDH protein co-treated with Acetaldehyde co-treated with Serotonin] affects the metabolism of and binds to GAPDH protein; [tryptamine-4,5-dione co-treated with Serotonin] affects the metabolism of and binds to GAPDH protein |
CTD |
PMID:23009681 |
|
NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:157,962,343...157,966,235
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G |
Ghrl |
ghrelin and obestatin prepropeptide |
decreases export |
EXP |
GHRL protein results in decreased export of Serotonin |
CTD |
PMID:20553917 |
|
NCBI chr 4:148,421,315...148,431,128
Ensembl chr 4:146,865,712...146,869,621
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G |
Gla |
galactosidase, alpha |
affects response to substance |
ISO |
GLA protein affects the susceptibility to Serotonin |
CTD |
PMID:18565198 |
|
NCBI chr X:102,062,497...102,073,915
Ensembl chr X:97,768,996...97,780,664
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G |
Gnai1 |
G protein subunit alpha i1 |
increases palmitoylation multiple interactions |
EXP |
Serotonin results in increased palmitoylation of GNAI1 protein Methiothepin inhibits the reaction [Serotonin results in increased palmitoylation of GNAI1 protein] |
CTD |
PMID:9732414 |
|
NCBI chr 4:17,706,061...17,790,176
Ensembl chr 4:16,814,001...16,896,417
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G |
Gnao1 |
G protein subunit alpha o1 |
multiple interactions increases palmitoylation |
EXP |
Methiothepin inhibits the reaction [Serotonin results in increased palmitoylation of GNAO1 protein] |
CTD |
PMID:9732414 |
|
NCBI chr19:11,040,788...11,198,437
Ensembl chr19:11,035,956...11,192,493
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G |
Gnaq |
G protein subunit alpha q |
multiple interactions increases palmitoylation |
EXP |
Methiothepin inhibits the reaction [Serotonin results in increased palmitoylation of GNAQ protein] |
CTD |
PMID:9732414 |
|
NCBI chr 1:222,852,453...223,098,754
Ensembl chr 1:213,424,465...213,667,672
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G |
Gnas |
GNAS complex locus |
multiple interactions increases palmitoylation |
EXP |
Methiothepin inhibits the reaction [Serotonin results in increased palmitoylation of GNAS protein] |
CTD |
PMID:9732414 |
|
NCBI chr 3:183,489,648...183,554,570
Ensembl chr 3:163,071,417...163,127,262 Ensembl chr 3:163,071,417...163,127,262
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G |
Gpbar1 |
G protein-coupled bile acid receptor 1 |
multiple interactions |
ISO |
[Bile Acids and Salts binds to and results in increased activity of GPBAR1 protein] which results in increased secretion of Serotonin |
CTD |
PMID:23041323 |
|
NCBI chr 9:83,309,895...83,312,397
Ensembl chr 9:75,860,677...75,863,168
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
increases phosphorylation |
ISO |
Serotonin results in increased phosphorylation of GSK3B protein |
CTD |
PMID:20190034 |
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NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
ISO |
Serotonin analog inhibits the reaction [Scopolamine results in decreased activity of GSR protein] |
CTD |
PMID:26408985 |
|
NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661
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G |
Htr1a |
5-hydroxytryptamine receptor 1A |
multiple interactions increases activity affects binding increases uptake increases expression affects response to substance |
EXP ISO |
[1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine binds to and results in decreased activity of HTR1A protein] which results in decreased susceptibility to Serotonin; [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in increased susceptibility to Serotonin; Fluoxetine inhibits the reaction [HTR1A protein results in increased uptake of Serotonin]; Guanosine Diphosphate affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]; Guanosine Triphosphate affects the reaction [Serotonin binds to HTR1A protein]; Guanosine Triphosphate affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]; Magnesium affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]; Manganese affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]; Manganese inhibits the reaction [Guanosine Triphosphate affects the reaction [Serotonin binds to HTR1A protein]]; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide promotes the reaction [Fluoxetine inhibits the reaction [HTR1A protein results in increased uptake of Serotonin]]; Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein] Serotonin results in increased activity of HTR1A protein Endocannabinoids inhibits the reaction [Serotonin binds to and results in increased activity of HTR1A protein]; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [Serotonin results in increased activity of HTR1A protein]; Serotonin binds to and results in increased activity of HTR1A protein Serotonin results in increased expression of HTR1A mRNA HTR1A protein affects the susceptibility to Serotonin |
CTD |
PMID:11106871 PMID:16528294 PMID:21083617 PMID:21126535 PMID:30102254 PMID:31323226 More...
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NCBI chr 2:38,427,169...38,431,733
Ensembl chr 2:36,694,174...36,695,442
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G |
Htr1b |
5-hydroxytryptamine receptor 1B |
affects binding multiple interactions |
EXP ISO |
Serotonin binds to HTR1B protein Endocannabinoids inhibits the reaction [Serotonin binds to and results in increased activity of HTR1B protein]; Serotonin binds to and results in increased activity of HTR1B protein |
CTD |
PMID:11888550 PMID:30102254 |
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NCBI chr 8:91,395,405...91,414,815
Ensembl chr 8:82,517,360...82,534,549
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G |
Htr1d |
5-hydroxytryptamine receptor 1D |
affects abundance |
ISO |
HTR1D gene polymorphism affects the abundance of Serotonin |
CTD |
PMID:17203304 |
|
NCBI chr 5:148,656,252...148,676,532
Ensembl chr 5:148,674,495...148,675,619
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G |
Htr1f |
5-hydroxytryptamine receptor 1F |
multiple interactions |
ISO |
Endocannabinoids inhibits the reaction [Serotonin binds to and results in increased activity of HTR1F protein]; Serotonin binds to and results in increased activity of HTR1F protein |
CTD |
PMID:30102254 |
|
NCBI chr11:2,642,751...2,644,150
Ensembl chr11:2,642,751...2,644,150
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G |
Htr2a |
5-hydroxytryptamine receptor 2A |
decreases response to substance affects response to substance affects binding increases expression multiple interactions |
ISO EXP |
HTR2A gene SNP results in decreased susceptibility to Serotonin HTR2A protein affects the susceptibility to Serotonin Serotonin binds to HTR2A protein Serotonin results in increased expression of HTR2A mRNA [Ketanserin binds to and results in decreased activity of HTR2A protein] inhibits the reaction [Methamphetamine results in decreased abundance of Serotonin]; [Ketanserin binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Serotonin; Phenoxybenzamine affects the reaction [Serotonin binds to HTR2A protein] HTR2A protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein] [Serotonin binds to and results in increased activity of HTR2A protein] which results in increased expression of and results in increased secretion of IL6 protein; Serotonin binds to and results in increased activity of HTR2A protein |
CTD |
PMID:8627522 PMID:11076827 PMID:11880652 PMID:16314884 PMID:16528294 PMID:19879056 PMID:21083617 More...
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NCBI chr15:56,360,647...56,428,703
Ensembl chr15:49,950,804...50,020,928
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G |
Htr2b |
5-hydroxytryptamine receptor 2B |
increases expression affects binding multiple interactions affects response to substance |
ISO EXP |
Serotonin results in increased expression of HTR2B mRNA Serotonin binds to HTR2B protein 1-(5-fluoropentyl)-3-(1-naphthoyl)indole inhibits the reaction [Serotonin binds to and results in increased activity of HTR2B protein]; 1-(8-bromobenzo(1,2-b;4,5-b')difuran-4-yl)-2-aminopropane inhibits the reaction [Serotonin binds to HTR2B protein]; 1-pentyl-3-(1-naphthoyl)indole inhibits the reaction [Serotonin binds to and results in increased activity of HTR2B protein]; 4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone inhibits the reaction [Serotonin binds to and results in increased activity of HTR2B protein]; JWH-073 inhibits the reaction [Serotonin binds to and results in increased activity of HTR2B protein]; Serotonin binds to and results in increased activity of HTR2B protein HTR2B protein affects the susceptibility to Serotonin |
CTD |
PMID:8627522 PMID:9857084 PMID:21083617 PMID:27449567 |
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NCBI chr 9:94,184,442...94,206,851
Ensembl chr 9:86,742,102...86,755,108
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G |
Htr2c |
5-hydroxytryptamine receptor 2C |
affects expression multiple interactions |
ISO EXP |
Serotonin affects the expression of HTR2C mRNA [Fluoxetine results in increased abundance of Serotonin] which results in decreased expression of HTR2C mRNA; Fluoxetine inhibits the reaction [Serotonin binds to and results in increased activity of HTR2C protein]; Serotonin binds to and results in increased activity of HTR2C protein |
CTD |
PMID:9050900 PMID:21083617 PMID:21554931 |
|
NCBI chr X:115,453,190...115,682,325
Ensembl chr X:110,641,153...110,870,287
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G |
Htr3a |
5-hydroxytryptamine receptor 3A |
multiple interactions increases activity affects localization |
ISO EXP |
1-Butanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]; 1-Butanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; 1-Propanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]; 1-Propanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Ethanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]; Ethanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Hexanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]; Hexanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Octanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]; Octanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Pentanols promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]; Pentanols promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]; Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein] Cocaine inhibits the reaction [Serotonin results in increased activity of HTR3A protein] Serotonin affects the localization of HTR3A protein alternative form 1,1,1-trichloroethane promotes the reaction [Serotonin results in increased activity of HTR3A protein]; Toluene promotes the reaction [Serotonin results in increased activity of HTR3A protein]; Trichloroethylene promotes the reaction [Serotonin results in increased activity of HTR3A protein] |
CTD |
PMID:12681521 PMID:17360702 PMID:17436349 PMID:32209479 |
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NCBI chr 8:58,138,514...58,150,960
Ensembl chr 8:49,242,020...49,254,389
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G |
Htr3b |
5-hydroxytryptamine receptor 3B |
multiple interactions |
ISO |
1-Butanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; 1-Propanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Ethanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Hexanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Octanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Pentanols promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]; Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein] |
CTD |
PMID:17360702 |
|
NCBI chr 8:58,175,785...58,204,939
Ensembl chr 8:49,279,173...49,308,444
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G |
Htr4 |
5-hydroxytryptamine receptor 4 |
multiple interactions |
ISO |
HTR4 protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein] |
CTD |
PMID:11880652 |
|
NCBI chr18:58,036,277...58,221,327
Ensembl chr18:55,766,725...55,949,321
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G |
Htr6 |
5-hydroxytryptamine receptor 6 |
multiple interactions |
ISO |
HTR6 protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]; Serotonin promotes the reaction [HTR6 protein results in increased abundance of Cyclic AMP] |
CTD |
PMID:11406289 PMID:11880652 |
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NCBI chr 5:156,579,901...156,595,147
Ensembl chr 5:151,296,662...151,311,912
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G |
Htr7 |
5-hydroxytryptamine receptor 7 |
multiple interactions |
ISO |
[Serotonin binds to and results in increased activity of HTR7 protein] which results in increased abundance of Cyclic AMP |
CTD |
PMID:14578406 |
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NCBI chr 1:243,049,064...243,173,636
Ensembl chr 1:233,636,452...233,760,626
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G |
Il12b |
interleukin 12B |
affects secretion |
ISO |
Serotonin affects the secretion of IL12B protein |
CTD |
PMID:15802305 |
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NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903
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G |
Il13 |
interleukin 13 |
affects response to substance |
ISO |
IL13 protein affects the susceptibility to Serotonin |
CTD |
PMID:12370375 |
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NCBI chr10:38,290,926...38,293,483
Ensembl chr10:37,790,130...37,792,737
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G |
Il1b |
interleukin 1 beta |
affects secretion multiple interactions increases expression |
ISO |
Serotonin affects the secretion of IL1B protein anandamide inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL1B protein]]; glyceryl 2-arachidonate inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL1B protein]]; GR 113808 inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL1B protein]]; Granisetron inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL1B protein]]; Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL1B protein] Serotonin results in increased expression of IL1B |
CTD |
PMID:15302781 PMID:15802305 PMID:30611738 |
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NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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G |
Il4 |
interleukin 4 |
affects response to substance |
ISO |
IL4 protein affects the susceptibility to Serotonin |
CTD |
PMID:12370375 |
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NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750
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G |
Il6 |
interleukin 6 |
affects expression multiple interactions increases expression affects secretion |
ISO |
Serotonin affects the expression of IL6 mRNA anandamide inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]]; glyceryl 2-arachidonate inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]]; GR 113808 inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]]; Granisetron inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]]; Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein] Serotonin results in increased expression of IL6 mRNA [Serotonin binds to and results in increased activity of HTR2A protein] which results in increased expression of and results in increased secretion of IL6 protein; calphostin C inhibits the reaction [Serotonin results in increased expression of and results in increased secretion of IL6 protein]; Ketanserin inhibits the reaction [Serotonin results in increased expression of and results in increased secretion of IL6 protein]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of and results in increased secretion of IL6 protein]; Serotonin results in increased expression of and results in increased secretion of IL6 protein Serotonin affects the secretion of IL6 protein |
CTD |
PMID:11076827 PMID:15302781 PMID:15802305 PMID:30611738 |
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NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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G |
Irs1 |
insulin receptor substrate 1 |
multiple interactions |
ISO |
[[Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]] which results in increased ubiquitination of and results in increased degradation of IRS1 protein; [Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]; [sarpogrelate results in increased activity of AKT1 protein] inhibits the reaction [Serotonin results in increased ubiquitination of and results in increased degradation of IRS1 protein]; Serotonin affects the localization of and results in increased ubiquitination of and results in increased degradation of IRS1 protein; Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein] |
CTD |
PMID:22975078 |
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NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:83,548,944...83,606,122
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G |
Itga2 |
integrin subunit alpha 2 |
multiple interactions |
ISO EXP |
ITGA2 protein promotes the reaction [[Dinoprostone co-treated with Serotonin] results in increased import of Calcium]; TRPV4 protein promotes the reaction [ITGA2 protein promotes the reaction [[Dinoprostone co-treated with Serotonin] results in increased import of Calcium]] ITGA2 protein results in increased susceptibility to [KNG1 protein modified form co-treated with TAC1 protein modified form co-treated with Serotonin co-treated with Dinoprostone co-treated with Histamine] |
CTD |
PMID:18234883 |
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NCBI chr 2:48,253,412...48,354,509
Ensembl chr 2:46,523,948...46,621,481
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G |
Itgam |
integrin subunit alpha M |
increases expression |
ISO |
Serotonin increases expression of Itgam protein on neutrophils |
RGD |
PMID:30586717 |
RGD:329853774 |
NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:182,659,000...182,709,503
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G |
Itgb3 |
integrin subunit beta 3 |
affects abundance |
ISO |
ITGB3 gene polymorphism affects the abundance of Serotonin |
CTD |
PMID:16724005 PMID:17203304 |
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NCBI chr10:90,009,927...90,067,787
Ensembl chr10:89,509,989...89,564,679
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G |
Kcnk3 |
potassium two pore domain channel subfamily K member 3 |
multiple interactions |
EXP |
Serotonin inhibits the reaction [KCNK3 protein results in increased transport of Potassium] |
CTD |
PMID:16020457 |
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NCBI chr 6:31,483,129...31,519,061
Ensembl chr 6:25,763,228...25,799,153
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G |
Kng1 |
kininogen 1 |
multiple interactions |
EXP |
[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased abundance of Dinoprostone; [KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein; [KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein; [Serotonin co-treated with Histamine] promotes the reaction [KNG1 protein results in increased abundance of Dinoprostone]; Dinoprostone promotes the reaction [Histamine promotes the reaction [Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]]]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased abundance of Dinoprostone]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [[Serotonin co-treated with Histamine] promotes the reaction [KNG1 protein results in increased abundance of Dinoprostone]]; Flurbiprofen inhibits the reaction [Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]]; Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]; Histamine promotes the reaction [Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]]; ITGA2 protein results in increased susceptibility to [KNG1 protein modified form co-treated with TAC1 protein modified form co-treated with Serotonin co-treated with Dinoprostone co-treated with Histamine]; Serotonin promotes the reaction [KNG1 protein results in increased abundance of Dinoprostone]; Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein] |
CTD |
PMID:11166334 PMID:12791437 PMID:18234883 |
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NCBI chr11:91,317,354...91,340,148
Ensembl chr11:77,812,752...77,835,555
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G |
Maoa |
monoamine oxidase A |
increases metabolic processing multiple interactions increases degradation decreases amination increases abundance |
ISO EXP |
MAOA protein results in increased metabolism of Serotonin [MAOA protein results in increased hydroxylation of Serotonin] which results in increased chemical synthesis of Hydroxyindoleacetic Acid MAOA protein results in increased degradation of Serotonin [MAOA protein results in increased metabolism of Serotonin] which results in increased abundance of hydroxyindoleacetaldehyde; Luteolin inhibits the reaction [[MAOA protein results in increased metabolism of Serotonin] which results in increased abundance of hydroxyindoleacetaldehyde]; Luteolin inhibits the reaction [MAOA protein results in increased metabolism of Serotonin]; Quercetin inhibits the reaction [[MAOA protein results in increased metabolism of Serotonin] which results in increased abundance of hydroxyindoleacetaldehyde]; Quercetin inhibits the reaction [MAOA protein results in increased metabolism of Serotonin] MAOA protein results in decreased amination of Serotonin 1-(8-bromobenzo(1,2-b;4,5-b')difuran-4-yl)-2-aminopropane inhibits the reaction [MAOA protein results in increased degradation of Serotonin]; 3,4-Methylenedioxyamphetamine inhibits the reaction [MAOA protein results in decreased amination of Serotonin]; Clorgyline inhibits the reaction [MAOA protein results in increased degradation of Serotonin]; Isocarboxazid inhibits the reaction [MAOA protein results in increased degradation of Serotonin]; Moclobemide inhibits the reaction [MAOA protein results in decreased amination of Serotonin]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [MAOA protein results in decreased amination of Serotonin]; Phenylpropanolamine inhibits the reaction [MAOA protein results in increased degradation of Serotonin] MAOA mutant form results in increased abundance of Serotonin MAOA gene polymorphism results in increased abundance of Serotonin |
CTD |
PMID:3961266 PMID:10647887 PMID:11834493 PMID:18405062 PMID:23009399 PMID:26721607 PMID:30036687 PMID:32243540 More...
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NCBI chr X:8,615,239...8,681,372
Ensembl chr X:6,030,795...6,099,593
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G |
Maob |
monoamine oxidase B |
increases abundance decreases amination multiple interactions |
ISO |
MAOB mutant form results in increased abundance of Serotonin MAOB protein results in decreased amination of Serotonin 3,4-Methylenedioxyamphetamine inhibits the reaction [MAOB protein results in decreased amination of Serotonin]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [MAOB protein results in decreased amination of Serotonin] |
CTD |
PMID:11834493 PMID:26721607 |
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NCBI chr X:8,490,405...8,594,065
Ensembl chr X:5,907,266...6,011,003
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases phosphorylation |
ISO |
Serotonin results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:30592962 |
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NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation |
ISO |
Serotonin results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:30592962 |
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NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
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G |
Mmp20 |
matrix metallopeptidase 20 |
decreases expression |
ISO |
Serotonin results in decreased expression of MMP20 mRNA |
CTD |
PMID:21083617 |
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NCBI chr 8:4,789,415...4,830,035
Ensembl chr 8:4,789,415...4,830,035
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G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO |
[MPO protein co-treated with XDH protein co-treated with Acetaldehyde co-treated with Serotonin] affects the metabolism of and binds to GAPDH protein; [MPO protein co-treated with XDH protein co-treated with Acetaldehyde] promotes the reaction [Serotonin binds to Acetylcysteine] glyceryl 2-arachidonate inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased activity of MPO protein]]; GR 113808 inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased activity of MPO protein]]; Granisetron inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased activity of MPO protein]]; Serotonin promotes the reaction [Dextran Sulfate results in increased activity of MPO protein] |
CTD |
PMID:23009681 PMID:30611738 |
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NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819
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G |
Mt1 |
metallothionein 1 |
multiple interactions |
ISO |
[MT1 gene mutant form co-treated with MT2 gene mutant form] results in increased abundance of Serotonin |
CTD |
PMID:18226494 |
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NCBI chr19:10,831,959...10,832,975
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049 Ensembl chr X:10,826,032...10,827,049
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G |
Mt2 |
metallothionein 2 |
multiple interactions |
ISO |
[MT1 gene mutant form co-treated with MT2 gene mutant form] results in increased abundance of Serotonin |
CTD |
PMID:18226494 |
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NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,832,002...10,832,784
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G |
Mtor |
mechanistic target of rapamycin kinase |
multiple interactions increases activity |
ISO |
sarpogrelate inhibits the reaction [Serotonin results in increased activity of MTOR protein]; Sirolimus inhibits the reaction [Serotonin results in increased activity of MTOR protein] |
CTD |
PMID:27133527 |
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NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311
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G |
Napepld |
N-acyl phosphatidylethanolamine phospholipase D |
multiple interactions |
ISO |
GR 113808 inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in decreased expression of NAPEPLD protein]]; Granisetron inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in decreased expression of NAPEPLD protein]]; Serotonin promotes the reaction [Dextran Sulfate results in decreased expression of NAPEPLD protein] |
CTD |
PMID:30611738 |
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NCBI chr 4:14,251,591...14,291,010
Ensembl chr 4:13,361,006...13,398,748
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
Serotonin analog inhibits the reaction [Scopolamine results in increased expression of NOS2 protein] |
CTD |
PMID:26408985 |
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NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions |
ISO |
Serotonin analog inhibits the reaction [Scopolamine results in decreased expression of NQO1 protein] |
CTD |
PMID:26408985 |
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NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557
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G |
Oprd1 |
opioid receptor, delta 1 |
multiple interactions |
EXP |
[dextrallorphan binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Dextromethorphan binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Dextropropoxyphene binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Dextrorphan binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Levallorphan binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Levorphanol binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Methadone binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Methadyl Acetate binds to OPRD1 protein] which results in decreased uptake of Serotonin; [Tramadol binds to OPRD1 protein] which results in decreased uptake of Serotonin |
CTD |
PMID:7562497 |
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NCBI chr 5:149,590,244...149,624,999
Ensembl chr 5:144,306,188...144,340,960
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G |
Oprk1 |
opioid receptor, kappa 1 |
multiple interactions |
EXP |
[dextrallorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Dextromethorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Dextropropoxyphene binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Dextrorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Levallorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Levorphanol binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Methadone binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Methadyl Acetate binds to OPRK1 protein] which results in decreased uptake of Serotonin; [Tramadol binds to OPRK1 protein] which results in decreased uptake of Serotonin |
CTD |
PMID:7562497 |
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NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:13,860,021...13,877,823
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G |
Oprm1 |
opioid receptor, mu 1 |
multiple interactions |
EXP |
[dextrallorphan binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Dextromethorphan binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Dextropropoxyphene binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Dextrorphan binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Levallorphan binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Levorphanol binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Methadone binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Methadyl Acetate binds to OPRM1 protein] which results in decreased uptake of Serotonin; [Tramadol binds to OPRM1 protein] which results in decreased uptake of Serotonin |
CTD |
PMID:7562497 |
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NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:43,160,057...43,413,409
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G |
Otc |
ornithine transcarbamylase |
affects metabolic processing multiple interactions |
ISO |
OTC gene mutant form affects the metabolism of Serotonin Sodium Benzoate affects the reaction [OTC gene mutant form affects the metabolism of Serotonin] |
CTD |
PMID:3374991 |
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NCBI chr X:15,126,358...15,202,473
Ensembl chr X:12,453,834...12,566,918
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G |
Oxt |
oxytocin/neurophysin I prepropeptide |
increases secretion |
ISO |
OXT protein results in increased secretion of Serotonin |
CTD |
PMID:19228979 |
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NCBI chr 3:138,235,754...138,236,594
Ensembl chr 3:117,782,650...117,783,490
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
affects abundance |
ISO |
PARP1 affects the abundance of Serotonin |
CTD |
PMID:21990073 |
|
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
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G |
Penk |
proenkephalin |
multiple interactions |
EXP |
Serotonin inhibits the reaction [Isoproterenol results in increased expression of PENK mRNA] |
CTD |
PMID:1363325 |
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NCBI chr 5:21,981,381...21,987,074
Ensembl chr 5:17,183,806...17,189,129
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
increases localization multiple interactions |
ISO |
Serotonin results in increased localization of PPARG protein [Serotonin results in increased localization of and results in increased activity of PPARG protein] which results in increased expression of AQP3 mRNA; Fluoxetine inhibits the reaction [Serotonin results in increased localization of PPARG protein] |
CTD |
PMID:25766885 |
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NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468
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G |
Ppp1r1b |
protein phosphatase 1, regulatory (inhibitor) subunit 1B |
multiple interactions increases phosphorylation decreases phosphorylation |
ISO |
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]; 2-methoxy-4-amino-5-chlorobenzoic acid 2-(diethylamino)ethyl ester inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; 2-methoxy-4-amino-5-chlorobenzoic acid 2-(diethylamino)ethyl ester inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]; Clozapine inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; Clozapine inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]; HTR2A protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]; HTR4 protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]; HTR6 protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]; Ketanserin inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]; Quinpirole affects the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; Quinpirole affects the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]; Ro 4-6790 inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; Ro 4-6790 inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]; SK&F 82958 promotes the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; SK&F 82958 promotes the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein] |
CTD |
PMID:11880652 |
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NCBI chr10:83,843,948...83,853,063
Ensembl chr10:83,347,731...83,356,775
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions increases expression |
ISO EXP |
Serotonin analog inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein] Serotonin results in increased expression of PTGS2 mRNA; Serotonin results in increased expression of PTGS2 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; AG 1879 inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; bisindolylmaleimide I inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; Calcium deficiency inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA] |
CTD |
PMID:21262218 PMID:26408985 |
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NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
increases activity |
ISO |
Serotonin results in increased activity of RELA protein |
CTD |
PMID:11076827 |
|
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
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G |
Serpine2 |
serpin family E member 2 |
multiple interactions |
ISO |
[TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA; [TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein; Rosuvastatin Calcium inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein] |
CTD |
PMID:24107419 PMID:27097221 |
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NCBI chr 9:88,573,138...88,637,252
Ensembl chr 9:81,124,804...81,188,826
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G |
Slc18a1 |
solute carrier family 18 member A1 |
multiple interactions increases uptake |
ISO |
1-Methyl-4-phenylpyridinium inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]; Dopamine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]; Histamine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]; Norepinephrine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]; phenethylamine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]; Reserpine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]; Tetrabenazine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin] |
CTD |
PMID:8245983 |
|
NCBI chr16:25,408,485...25,453,786
Ensembl chr16:20,653,508...20,687,051
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G |
Slc18a2 |
solute carrier family 18 member A2 |
affects binding increases uptake increases transport multiple interactions affects uptake |
ISO EXP |
Serotonin binds to SLC18A2 protein Serotonin binds to Slc8a2 protein SLC18A2 protein binds to Serotonin SLC18A2 protein results in increased uptake of Serotonin SLC18A2 protein results in increased transport of Serotonin Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Dopamine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Norepinephrine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Reserpine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Serotonin inhibits the reaction [SLC18A2 protein binds to Reserpine]; Serotonin inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Tetrabenazine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; tributyltin inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Valinomycin promotes the reaction [SLC18A2 protein results in increased uptake of Serotonin] SLC18A2 gene SNP affects the uptake of Serotonin |
CTD RGD |
PMID:1438304 PMID:7912402 PMID:9038139 PMID:15475732 PMID:18287335 PMID:20007701 More...
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RGD:5130957 |
NCBI chr 1:268,399,815...268,435,229
Ensembl chr 1:258,413,959...258,448,325
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G |
Slc22a16 |
solute carrier family 22 member 16 |
multiple interactions |
ISO |
Serotonin inhibits the reaction [SLC22A16 protein results in increased uptake of Tetraethylammonium] |
CTD |
PMID:15963465 |
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NCBI chr20:45,527,275...45,647,675
Ensembl chr20:43,972,836...44,065,019
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G |
Slc22a3 |
solute carrier family 22 member 3 |
multiple interactions increases uptake |
EXP ISO |
Serotonin inhibits the reaction [SLC22A3 protein results in increased transport of Histamine]; Serotonin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] SLC22A3 protein results in increased uptake of Serotonin |
CTD |
PMID:9830022 PMID:16928864 PMID:20858707 |
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NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:48,235,476...48,324,612
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G |
Slc29a4 |
solute carrier family 29 member 4 |
increases uptake |
ISO |
SLC29A4 protein results in increased uptake of Serotonin |
CTD |
PMID:20858707 |
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NCBI chr12:11,853,540...11,884,660
Ensembl chr12:11,853,540...11,874,834
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G |
Slc47a1 |
solute carrier family 47 member 1 |
multiple interactions |
ISO |
Serotonin inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:22419765 |
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NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,034,122...46,087,637
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G |
Slc47a2 |
solute carrier family 47 member 2 |
multiple interactions |
ISO |
Serotonin inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:22419765 |
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NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
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G |
Slc6a2 |
solute carrier family 6 member 2 |
multiple interactions |
ISO |
SLC6A2 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein] |
CTD |
PMID:17234900 |
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NCBI chr19:30,183,289...30,228,292
Ensembl chr19:14,010,386...14,050,357
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G |
Slc6a3 |
solute carrier family 6 member 3 |
multiple interactions increases uptake |
ISO |
SLC6A3 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein] SLC6A3 protein results in increased uptake of Serotonin |
CTD |
PMID:17234900 PMID:17250655 |
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NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:29,709,443...29,750,413
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G |
Slc6a4 |
solute carrier family 6 member 4 |
multiple interactions increases activity decreases activity increases uptake affects binding increases expression affects abundance |
ISO EXP |
4-methylaminorex inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]; [SLC6A4 gene polymorphism results in decreased uptake of Serotonin] which results in decreased susceptibility to Clozapine; Cocaine inhibits the reaction [Serotonin results in increased activity of SLC6A4 protein]; Lamivudine promotes the reaction [SLC6A4 protein results in increased uptake of Serotonin]; Monensin promotes the reaction [para-methyl-4-methylaminorex inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]; para-methyl-4-methylaminorex inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]; Ribavirin promotes the reaction [SLC6A4 protein results in increased uptake of Serotonin]; SLC6A4 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein] serotonin decreases activity of Slc6a4 protein in epithelial colorectal adenocarcinoma cells Serotonin binds to SLC6A4 protein 4-methylaminorex inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]; [Fluoxetine results in decreased expression of SLC6A4 mRNA] which results in decreased abundance of Serotonin; Aminorex inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]; Dextroamphetamine inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]; para-methyl-4-methylaminorex inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin] Serotonin results in increased expression of SLC6A4 mRNA SLC6A4 gene polymorphism affects the abundance of Serotonin |
CTD RGD |
PMID:15972295 PMID:16272152 PMID:16476009 PMID:16982082 PMID:17203304 PMID:17234900 PMID:20452607 PMID:21083617 PMID:24841869 PMID:29908239 PMID:30776375 PMID:33785354 PMID:19747920 More...
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RGD:36947380 |
NCBI chr10:62,322,688...62,357,060
Ensembl chr10:61,826,123...61,858,384
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G |
Sorl1 |
sortilin related receptor 1 |
multiple interactions increases expression |
ISO |
sarpogrelate inhibits the reaction [Serotonin results in increased expression of SORL1 mRNA] |
CTD |
PMID:24650663 |
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NCBI chr 8:51,238,713...51,401,458
Ensembl chr 8:42,341,704...42,504,513
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G |
Stxbp3 |
syntaxin binding protein 3 |
affects secretion |
ISO |
STXBP3 protein affects the secretion of Serotonin |
CTD |
PMID:18556422 |
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NCBI chr 2:199,130,725...199,173,823
Ensembl chr 2:196,442,634...196,485,671
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G |
Sult1a1 |
sulfotransferase family 1A member 1 |
increases sulfation |
ISO EXP |
SULT1A1 protein results in increased sulfation of Serotonin |
CTD |
PMID:11181495 |
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NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:181,272,023...181,275,562
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G |
Taar1 |
trace-amine-associated receptor 1 |
multiple interactions |
ISO |
SLC6A2 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein]; SLC6A3 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein]; SLC6A4 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein] |
CTD |
PMID:17234900 |
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NCBI chr 1:23,336,978...23,337,976
Ensembl chr 1:21,517,258...21,532,084
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G |
Tac1 |
tachykinin, precursor 1 |
multiple interactions |
EXP |
Dinoprostone promotes the reaction [Histamine promotes the reaction [Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]]]; Histamine promotes the reaction [Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]]; ITGA2 protein results in increased susceptibility to [KNG1 protein modified form co-treated with TAC1 protein modified form co-treated with Serotonin co-treated with Dinoprostone co-treated with Histamine]; Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein] |
CTD |
PMID:11166334 PMID:18234883 |
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NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:35,679,704...35,687,178
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G |
Tdo2 |
tryptophan 2,3-dioxygenase |
multiple interactions |
EXP |
[Sulindac results in decreased activity of TDO2 protein] which results in increased abundance of Serotonin; [Tolmetin results in decreased activity of TDO2 protein] which results in increased abundance of Serotonin |
CTD |
PMID:16952380 |
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NCBI chr 2:169,567,656...169,585,586
Ensembl chr 2:167,269,579...167,287,511
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
[TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA; [TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein; Rosuvastatin Calcium inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein] |
CTD |
PMID:24107419 PMID:27097221 |
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NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
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G |
Tnf |
tumor necrosis factor |
affects secretion multiple interactions increases expression |
ISO |
Serotonin affects the secretion of TNF protein [Serotonin co-treated with Dextran Sulfate] results in increased expression of TNF protein; anandamide inhibits the reaction [[Serotonin co-treated with Dextran Sulfate] results in increased expression of TNF protein]; glyceryl 2-arachidonate inhibits the reaction [[Serotonin co-treated with Dextran Sulfate] results in increased expression of TNF protein] Serotonin results in increased expression of TNF |
CTD |
PMID:15302781 PMID:15802305 PMID:30611738 |
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NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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G |
Tph1 |
tryptophan hydroxylase 1 |
affects abundance multiple interactions increases chemical synthesis increases abundance |
ISO |
TPH1 gene polymorphism affects the abundance of Serotonin Granisetron inhibits the reaction [Serotonin inhibits the reaction [Dextran Sulfate results in increased expression of TPH1 protein]]; Serotonin inhibits the reaction [Dextran Sulfate results in increased expression of TPH1 protein] TPH1 protein results in increased chemical synthesis of Serotonin TPH1 gene polymorphism results in increased abundance of Serotonin |
CTD |
PMID:17203304 PMID:18405062 PMID:18506000 PMID:30611738 |
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NCBI chr 1:106,293,695...106,314,628
Ensembl chr 1:97,157,409...97,178,344
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G |
Tph2 |
tryptophan hydroxylase 2 |
affects abundance |
ISO |
TPH2 protein affects the abundance of Serotonin |
CTD |
PMID:20722968 |
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NCBI chr 7:52,571,909...52,676,305
Ensembl chr 7:50,685,694...50,789,424
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G |
Trpa1 |
transient receptor potential cation channel, subfamily A, member 1 |
multiple interactions |
ISO |
TRPA1 mRNA affects the reaction [Acrolein results in increased secretion of Serotonin]; TRPA1 mRNA affects the reaction [allyl isothiocyanate results in increased secretion of Serotonin]; TRPA1 mRNA affects the reaction [cinnamaldehyde results in increased secretion of Serotonin] |
CTD |
PMID:19507004 |
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NCBI chr 5:9,163,060...9,217,325
Ensembl chr 5:4,379,999...4,433,570
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G |
Trpv1 |
transient receptor potential cation channel, subfamily V, member 1 |
multiple interactions |
EXP |
Serotonin promotes the reaction [[Capsaicin results in increased activity of TRPV1 protein] which results in increased transport of Calcium] |
CTD |
PMID:16901936 |
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NCBI chr10:58,349,936...58,375,021
Ensembl chr10:57,851,428...57,876,513
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G |
Trpv4 |
transient receptor potential cation channel, subfamily V, member 4 |
multiple interactions |
ISO |
TRPV4 protein promotes the reaction [ITGA2 protein promotes the reaction [[Dinoprostone co-treated with Serotonin] results in increased import of Calcium]] |
CTD |
PMID:18234883 |
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NCBI chr12:47,599,161...47,638,143
Ensembl chr12:41,938,560...41,977,517
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G |
Ugt1a6 |
UDP glucuronosyltransferase family 1 member A6 |
increases glucuronidation affects glucuronidation multiple interactions |
ISO |
UGT1A6 protein results in increased glucuronidation of Serotonin; UGT1A6 protein results in increased glucuronidation of Serotonin metabolite UGT1A6 gene polymorphism affects the glucuronidation of Serotonin; UGT1A6 gene polymorphism affects the glucuronidation of Serotonin metabolite bisphenol A inhibits the reaction [UGT1A6 protein results in increased glucuronidation of Serotonin] |
CTD |
PMID:15761113 PMID:15761114 PMID:18214896 |
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NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:88,713,184...88,808,465
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions |
ISO |
[Glucose co-treated with Serotonin] results in increased expression of VCAM1 protein; sarpogrelate inhibits the reaction [[Glucose co-treated with Serotonin] results in increased expression of VCAM1 protein] |
CTD |
PMID:22785018 |
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NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958
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G |
Xdh |
xanthine dehydrogenase |
multiple interactions |
ISO |
[MPO protein co-treated with XDH protein co-treated with Acetaldehyde co-treated with Serotonin] affects the metabolism of and binds to GAPDH protein; [MPO protein co-treated with XDH protein co-treated with Acetaldehyde] promotes the reaction [Serotonin binds to Acetylcysteine] |
CTD |
PMID:23009681 |
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NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:21,530,113...21,592,268
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G |
Ywhab |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta |
multiple interactions |
ISO |
[[Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]] which results in increased ubiquitination of and results in increased degradation of IRS1 protein; [Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]; Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein] |
CTD |
PMID:22975078 |
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NCBI chr 3:173,078,904...173,101,508
Ensembl chr 3:152,659,651...152,682,105
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G |
Htr3a |
5-hydroxytryptamine receptor 3A |
multiple interactions |
ISO |
2-methyl-5-HT binds to and results in increased activity of HTR3A protein |
CTD |
PMID:15802305 |
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NCBI chr 8:58,138,514...58,150,960
Ensembl chr 8:49,242,020...49,254,389
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
2-methyl-5-HT promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] |
CTD |
PMID:15802305 |
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NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
2-methyl-5-HT promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] |
CTD |
PMID:15802305 |
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NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
decreases activity multiple interactions |
ISO |
5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2B6 protein [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion |
CTD |
PMID:26599973 |
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NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
multiple interactions decreases activity |
ISO |
[5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole |
CTD |
PMID:26599973 |
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NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp2d1 |
cytochrome P450, family 2, subfamily d, polypeptide 1 |
increases metabolic processing |
EXP |
CYP2D1 protein results in increased metabolism of 5-methoxy-N,N-diisopropyltryptamine |
CTD |
PMID:18191824 |
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NCBI chr 7:115,789,026...115,793,430
Ensembl chr 7:113,908,947...113,922,084
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G |
Cyp2d2 |
cytochrome P450, family 2, subfamily d, polypeptide 2 |
increases metabolic processing |
EXP |
CYP2D2 protein results in increased metabolism of 5-methoxy-N,N-diisopropyltryptamine |
CTD |
PMID:18191824 |
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NCBI chr 7:115,815,212...115,819,281
Ensembl chr 7:113,935,138...113,939,209
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
multiple interactions decreases activity |
ISO |
[5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan |
CTD |
PMID:26599973 |
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NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions decreases activity |
ISO |
[5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone |
CTD |
PMID:26599973 |
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NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
multiple interactions |
ISO |
CYP2D6 protein binds to and results in decreased methylation of 5-Methoxytryptamine |
CTD |
PMID:12777961 |
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NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759
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G |
Htr7 |
5-hydroxytryptamine receptor 7 |
multiple interactions |
ISO |
[5-Methoxytryptamine binds to and results in increased activity of HTR7 protein] which results in increased abundance of Cyclic AMP |
CTD |
PMID:14578406 |
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NCBI chr 1:243,049,064...243,173,636
Ensembl chr 1:233,636,452...233,760,626
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G |
Kmo |
kynurenine 3-monooxygenase |
increases expression |
EXP |
5-Methoxytryptamine results in increased expression of KMO mRNA |
CTD |
PMID:32243540 |
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NCBI chr13:90,089,340...90,121,108
Ensembl chr13:87,557,286...87,588,881
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G |
Ppp1r1b |
protein phosphatase 1, regulatory (inhibitor) subunit 1B |
decreases phosphorylation increases phosphorylation |
ISO |
5-Methoxytryptamine results in decreased phosphorylation of PPP1R1B protein 5-Methoxytryptamine results in increased phosphorylation of PPP1R1B protein |
CTD |
PMID:11880652 |
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NCBI chr10:83,843,948...83,853,063
Ensembl chr10:83,347,731...83,356,775
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G |
Sod2 |
superoxide dismutase 2 |
decreases expression |
EXP |
5-Methoxytryptamine results in decreased expression of SOD2 mRNA |
CTD |
PMID:32243540 |
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NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189
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G |
Taar1 |
trace-amine-associated receptor 1 |
increases activity multiple interactions |
ISO |
5-Methoxytryptamine results in increased activity of TAAR1 protein [5-Methoxytryptamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP |
CTD |
PMID:19725810 |
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NCBI chr 1:23,336,978...23,337,976
Ensembl chr 1:21,517,258...21,532,084
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G |
Tph1 |
tryptophan hydroxylase 1 |
decreases expression |
EXP |
5-Methoxytryptamine results in decreased expression of TPH1 mRNA |
CTD |
PMID:32243540 |
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NCBI chr 1:106,293,695...106,314,628
Ensembl chr 1:97,157,409...97,178,344
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G |
Cat |
catalase |
multiple interactions |
ISO |
N-acetylserotonin inhibits the reaction [cyfluthrin results in decreased activity of CAT protein] |
CTD |
PMID:19961921 |
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NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
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G |
Ugt1a6 |
UDP glucuronosyltransferase family 1 member A6 |
multiple interactions increases glucuronidation |
ISO |
methyl 2-(2-acetoxy-6,7-dihydrothieno(3,2-c)pyridin-5(4H)-yl)-2-(2-chlorophenyl)acetate inhibits the reaction [UGT1A6 protein results in increased glucuronidation of N-acetylserotonin] |
CTD |
PMID:34910929 |
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NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:88,713,184...88,808,465
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