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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:zinc protoporphyrin
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Accession:CHEBI:28783 term browser browse the term
Definition:A metalloprotoporphyrin that has formula C34H32N4O4Zn.
Synonyms:exact_synonym: (protoporphyrinato)zinc(II)
 related_synonym: (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)zinc(II);   Formula=C34H32N4O4Zn;   InChI=1S/C34H34N4O4.Zn/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);/q;+2/p-2/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;;   InChIKey=FUTVBRXUIKZACV-RGGAHWMASA-L;   PROTOPORPHYRIN IX CONTAINING ZN;   SMILES=CC1=C(CCC(O)=O)C2=[N]3C1=Cc1c(C)c(C=C)c4C=C5C(C)=C(C=C)C6=[N]5[Zn]3(n14)n1c(=C6)c(C)c(CCC(O)=O)c1=C2;   ZPP;   Zinc protoporphyrin-9;   Zn(ppIX);   zinc-protoporphyrin IX
 alt_id: CHEBI:10114;   CHEBI:27366
 xref: Beilstein:4932319;   Beilstein:8184206;   CAS:15442-64-5;   DrugBank:DB03934;   Gmelin:403138;   KEGG:C03184
 xref_mesh: MESH:C017803
 xref: PDBeChem:ZNH



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zinc protoporphyrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions EXP
ISO
zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]]; zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]]
zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]
CTD PMID:20052772 PMID:20861358 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778
JBrowse link
G Agt angiotensinogen multiple interactions ISO [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [neferine inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]]; [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [neferine inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]] CTD PMID:20523338 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO zinc protoporphyrin inhibits the reaction [olprinone results in increased activity of AKT1 protein] CTD PMID:19387321 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Alad aminolevulinate, delta-, dehydratase affects abundance ISO ALAD gene SNP affects the abundance of zinc protoporphyrin CTD PMID:25963508 NCBI chr 4:62,422,762...62,438,300
Ensembl chr 4:62,427,406...62,438,155
JBrowse link
G Alb albumin multiple interactions EXP
ISO
ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [Peptidoglycan results in increased expression of NOS2 protein]]; ALB protein inhibits the reaction [zinc protoporphyrin results in increased expression of HMOX1 protein]
zinc protoporphyrin inhibits the reaction [ALB protein results in increased expression of HMOX1 protein]; zinc protoporphyrin promotes the reaction [ALB protein results in increased expression of TIMP1 protein]
CTD PMID:19376148 PMID:21163135 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
JBrowse link
G Alms1 ALMS1, centrosome and basal body associated multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of ALMS1 mRNA CTD PMID:22839698 NCBI chr 6:85,564,482...85,698,973
Ensembl chr 6:85,564,513...85,679,735
JBrowse link
G Ap2a1 adaptor-related protein complex 2, alpha 1 subunit multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of AP2A1 mRNA CTD PMID:22839698 NCBI chr 7:44,549,797...44,578,914
Ensembl chr 7:44,549,797...44,578,920
JBrowse link
G Ap3d1 adaptor-related protein complex 3, delta 1 subunit multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of AP3D1 mRNA CTD PMID:22839698 NCBI chr10:80,542,790...80,578,137
Ensembl chr10:80,542,790...80,578,098
JBrowse link
G Asf1a anti-silencing function 1A histone chaperone multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of ASF1A mRNA CTD PMID:22839698 NCBI chr10:53,473,057...53,485,321
Ensembl chr10:53,472,853...53,485,321
JBrowse link
G Bax BCL2-associated X protein multiple interactions EXP
ISO
zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]]; zinc protoporphyrin inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]
zinc protoporphyrin inhibits the reaction [Cisplatin results in increased expression of BAX protein]
zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]]
CTD PMID:22763982 PMID:27523796 PMID:27815112 PMID:32621855 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions EXP
ISO
zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; zinc protoporphyrin inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]
zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]]
CTD PMID:22763982 PMID:27523796 PMID:32621855 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions
increases expression
ISO zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of BCL2L1 protein]
zinc protoporphyrin results in increased expression of BCL2L1 protein
CTD PMID:20357190 PMID:27829220 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648
JBrowse link
G Bcl2l11 BCL2 like 11 increases expression ISO zinc protoporphyrin results in increased expression of BCL2L11 protein CTD PMID:27829220 NCBI chr 2:127,967,958...128,004,467
Ensembl chr 2:127,967,958...128,004,467
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO zinc protoporphyrin analog inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of BIRC3 protein] CTD PMID:18508827 NCBI chr 9:7,848,698...7,873,199
Ensembl chr 9:7,848,700...7,873,187
JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha multiple interactions ISO zinc protoporphyrin inhibits the reaction [monophosphoryl lipid A results in increased expression of CALCA mRNA] CTD PMID:11738242 NCBI chr 7:114,225,223...114,236,145
Ensembl chr 7:114,230,713...114,235,592
JBrowse link
G Cand1 cullin associated and neddylation disassociated 1 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of CAND1 mRNA CTD PMID:22839698 NCBI chr10:119,034,717...119,075,960
Ensembl chr10:119,035,160...119,075,960
JBrowse link
G Casp1 caspase 1 multiple interactions ISO zinc protoporphyrin inhibits the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased cleavage of CASP1 protein]] CTD PMID:36858639 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases activity
increases cleavage
EXP
ISO
zinc protoporphyrin inhibits the reaction [[Glucose deficiency co-treated with Simvastatin] results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [Resveratrol inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]]; zinc protoporphyrin inhibits the reaction [sesamol inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]]; zinc protoporphyrin promotes the reaction [T-2 Toxin results in increased activity of CASP3 protein]
zinc protoporphyrin results in decreased activity of CASP3 protein
zinc protoporphyrin inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in decreased expression of CASP3 protein]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of CASP3 mRNA]]; zinc protoporphyrin promotes the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased cleavage of CASP3 protein]; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased cleavage of CASP3 protein]
zinc protoporphyrin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased activity of CASP3 protein]]; zinc protoporphyrin inhibits the reaction [FASLG protein results in increased activity of CASP3 protein]; zinc protoporphyrin inhibits the reaction [FASLG protein results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]]; zinc protoporphyrin promotes the reaction [arsenic trioxide results in increased activity of CASP3 protein]; zinc protoporphyrin promotes the reaction [quinocetone results in increased activity of CASP3 protein]
zinc protoporphyrin results in increased cleavage of CASP3 protein
CTD PMID:16051694 PMID:17928392 PMID:20357190 PMID:21295052 PMID:22763982 More... NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp8 caspase 8 multiple interactions ISO zinc protoporphyrin inhibits the reaction [FASLG protein results in increased activity of CASP8 protein] CTD PMID:16051694 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
JBrowse link
G Casp9 caspase 9 multiple interactions ISO
EXP
zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased activity of CASP9 protein]]; zinc protoporphyrin promotes the reaction [quinocetone results in increased activity of CASP9 protein]
zinc protoporphyrin inhibits the reaction [sesamol inhibits the reaction [Lipopolysaccharides results in increased activity of CASP9 protein]]; zinc protoporphyrin promotes the reaction [T-2 Toxin results in increased activity of CASP9 protein]
CTD PMID:27375190 PMID:29432840 PMID:30261164 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Cat catalase multiple interactions ISO
EXP
zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in decreased expression of CAT protein]]
zinc protoporphyrin inhibits the reaction [8-oxoberberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of CAT protein]]
CTD PMID:32621855 PMID:35691465 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Ccdc6 coiled-coil domain containing 6 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of CCDC6 mRNA CTD PMID:22839698 NCBI chr10:69,932,709...70,029,030
Ensembl chr10:69,932,951...70,029,030
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP
zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in decreased expression of CCL2 protein]; zinc protoporphyrin promotes the reaction [Indomethacin results in increased expression of CCL2 mRNA]
zinc protoporphyrin inhibits the reaction [8-oxoberberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of CCL2 protein]]
CTD PMID:20357190 PMID:23892052 PMID:35691465 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 multiple interactions EXP zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of CCR7 mRNA] CTD PMID:33049506 NCBI chr11:99,035,025...99,045,903
Ensembl chr11:99,035,022...99,045,903
JBrowse link
G Cd40 CD40 antigen multiple interactions EXP zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA] CTD PMID:33049506 NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868
JBrowse link
G Cd80 CD80 antigen multiple interactions EXP zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 mRNA] CTD PMID:33049506 NCBI chr16:38,277,793...38,316,682
Ensembl chr16:38,275,923...38,316,697
JBrowse link
G Cd83 CD83 antigen multiple interactions EXP zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of CD83 mRNA] CTD PMID:33049506 NCBI chr13:43,938,661...43,956,608
Ensembl chr13:43,938,251...43,956,608
JBrowse link
G Cd86 CD86 antigen multiple interactions EXP zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 mRNA] CTD PMID:33049506 NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443
JBrowse link
G Cdk13 cyclin dependent kinase 13 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of CDK13 mRNA CTD PMID:22839698 NCBI chr13:17,885,309...17,979,960
Ensembl chr13:17,884,900...17,979,682
JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A multiple interactions ISO zinc protoporphyrin analog inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of and affects the localization of CDKN1A protein] CTD PMID:18508827 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Chd7 chromodomain helicase DNA binding protein 7 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of CHD7 mRNA CTD PMID:22839698 NCBI chr 4:8,690,345...8,868,449
Ensembl chr 4:8,690,406...8,867,659
JBrowse link
G Cmbl carboxymethylenebutenolidase homolog multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of CMBL mRNA CTD PMID:22839698 NCBI chr15:31,565,314...31,590,266
Ensembl chr15:31,565,535...31,590,265
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression ISO zinc protoporphyrin results in increased expression of CXCL1 mRNA CTD PMID:25780291 NCBI chr 5:91,039,104...91,040,980
Ensembl chr 5:91,039,100...91,040,974
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions EXP zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]] CTD PMID:20861358 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO zinc protoporphyrin results in increased expression of CXCL2 mRNA CTD PMID:25780291 NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP1A1 protein CTD PMID:26747958 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP1A2 protein CTD PMID:26747958 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
JBrowse link
G Cyp2a5 cytochrome P450, family 2, subfamily a, polypeptide 5 multiple interactions EXP [zinc protoporphyrin co-treated with Hemin] results in increased expression of CYP2A5 mRNA CTD PMID:22859313 NCBI chr 7:26,534,764...26,542,689
Ensembl chr 7:26,534,730...26,542,973
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP2E1 mRNA; [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP2E1 protein; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 mRNA]; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 protein]
zinc protoporphyrin inhibits the reaction [Quercetin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]]; zinc protoporphyrin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer inhibits the reaction [Ethanol results in increased activity of CYP2E1 protein]]
CTD PMID:19325051 PMID:26747958 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
JBrowse link
G Dcun1d1 defective in cullin neddylation 1 domain containing 1 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of DCUN1D1 mRNA CTD PMID:22839698 NCBI chr 3:35,946,254...35,991,626
Ensembl chr 3:35,946,254...35,991,594
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO zinc protoporphyrin promotes the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of DDIT3 protein]; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of DDIT3 protein] CTD PMID:26747958 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157
JBrowse link
G Dhx29 DExH-box helicase 29 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of DHX29 mRNA CTD PMID:22839698 NCBI chr13:113,063,976...113,105,968
Ensembl chr13:113,063,988...113,105,966
JBrowse link
G Dusp10 dual specificity phosphatase 10 multiple interactions ISO zinc protoporphyrin inhibits the reaction [andrographolide results in increased expression of DUSP10 mRNA]; zinc protoporphyrin inhibits the reaction [andrographolide results in increased expression of DUSP10 protein] CTD PMID:29165873 NCBI chr 1:183,766,575...183,807,833
Ensembl chr 1:183,745,499...183,807,833
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO zinc protoporphyrin promotes the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased phosphorylation of EIF2AK3 protein]; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased phosphorylation of EIF2AK3 protein] CTD PMID:26747958 NCBI chr 6:70,821,468...70,882,225
Ensembl chr 6:70,821,499...70,882,229
JBrowse link
G Eml4 echinoderm microtubule associated protein like 4 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of EML4 mRNA CTD PMID:22839698 NCBI chr17:83,658,341...83,787,790
Ensembl chr17:83,658,360...83,787,790
JBrowse link
G F2 coagulation factor II multiple interactions ISO zinc protoporphyrin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer inhibits the reaction [F2 protein results in increased expression of PTGS2 protein]]; zinc protoporphyrin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer inhibits the reaction [F2 protein results in increased secretion of Dinoprostone]] CTD PMID:26385185 NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759
JBrowse link
G Fasl Fas ligand multiple interactions ISO zinc protoporphyrin inhibits the reaction [FASLG protein results in increased activity of CASP3 protein]; zinc protoporphyrin inhibits the reaction [FASLG protein results in increased activity of CASP8 protein]; zinc protoporphyrin inhibits the reaction [FASLG protein results in increased cleavage of CASP3 protein] CTD PMID:16051694 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064
JBrowse link
G Fbxw13 F-box and WD-40 domain protein 13 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of FBXW12 mRNA CTD PMID:22839698 NCBI chr 9:109,008,295...109,025,043
Ensembl chr 9:109,008,295...109,025,043
JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of FGFR1 mRNA CTD PMID:22839698 NCBI chr 8:26,008,808...26,067,819
Ensembl chr 8:26,003,670...26,065,734
JBrowse link
G Flt1 FMS-like tyrosine kinase 1 multiple interactions ISO zinc protoporphyrin inhibits the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]] CTD PMID:25371888 NCBI chr 5:147,498,414...147,663,419
Ensembl chr 5:147,498,414...147,662,821
JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression ISO zinc protoporphyrin results in increased expression of FOS mRNA CTD PMID:10381381 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
JBrowse link
G Fut4 fucosyltransferase 4 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of FUT4 mRNA CTD PMID:22839698 NCBI chr 9:14,659,755...14,663,418
Ensembl chr 9:14,659,616...14,663,689
JBrowse link
G Glul glutamate-ammonia ligase multiple interactions ISO zinc protoporphyrin inhibits the reaction [resveratrol inhibits the reaction [Ammonia results in decreased activity of GLUL protein]]; zinc protoporphyrin inhibits the reaction [resveratrol results in increased activity of GLUL protein] CTD PMID:26318273 NCBI chr 1:153,775,692...153,785,469
Ensembl chr 1:153,775,690...153,785,469
JBrowse link
G Gm9920 predicted gene 9920 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of FAM106A mRNA CTD PMID:22839698 NCBI chr15:54,963,313...54,976,978
Ensembl chr15:54,963,313...54,977,073
JBrowse link
G Gpr132 G protein-coupled receptor 132 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of GPR132 mRNA CTD PMID:22839698 NCBI chr12:112,814,493...112,832,035
Ensembl chr12:112,814,493...112,831,848
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO zinc protoporphyrin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of GPX1 protein] CTD PMID:36696656 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542
JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO zinc protoporphyrin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of GPX4 protein] CTD PMID:36696656 NCBI chr10:79,883,000...79,892,273
Ensembl chr10:79,883,000...79,892,273
JBrowse link
G Gsdmd gasdermin D multiple interactions ISO zinc protoporphyrin inhibits the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased cleavage of GSDMD protein]] CTD PMID:36858639 NCBI chr15:75,733,990...75,739,257
Ensembl chr15:75,734,176...75,739,257
JBrowse link
G Gucy1a1 guanylate cyclase 1, soluble, alpha 1 multiple interactions ISO zinc protoporphyrin inhibits the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]] CTD PMID:19466990 NCBI chr 3:81,999,734...82,053,253
Ensembl chr 3:81,999,734...82,053,096
JBrowse link
G Gucy1b1 guanylate cyclase 1, soluble, beta 1 multiple interactions ISO zinc protoporphyrin inhibits the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]] CTD PMID:19466990 NCBI chr 3:81,939,311...81,982,018
Ensembl chr 3:81,939,313...81,981,996
JBrowse link
G Haus2 HAUS augmin-like complex, subunit 2 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of HAUS2 mRNA CTD PMID:22839698 NCBI chr 2:120,439,863...120,452,041
Ensembl chr 2:120,439,864...120,452,041
JBrowse link
G Hfe homeostatic iron regulator affects abundance ISO HFE gene polymorphism affects the abundance of zinc protoporphyrin CTD PMID:25963508 NCBI chr13:23,886,017...23,894,837
Ensembl chr13:23,886,017...23,894,837
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions ISO zinc protoporphyrin inhibits the reaction [HIF1A protein results in increased activity of SOD2 protein] CTD PMID:17066447 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO
EXP
zinc protoporphyrin promotes the reaction [lead acetate results in increased expression of HMGB1 mRNA]
zinc protoporphyrin inhibits the reaction [sesamol inhibits the reaction [Lipopolysaccharides results in increased expression of HMGB1 protein]]
CTD PMID:29447957 PMID:30261164 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
decreases activity
affects expression
decreases expression
ISO
EXP
[zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [cobaltiprotoporphyrin results in increased expression of TP53 protein]; [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [neferine inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]]; [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [neferine inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]]; [zinc protoporphyrin results in decreased activity of HMOX1 protein] which results in increased susceptibility to 2-butenal; [zinc protoporphyrin results in decreased activity of HMOX1 protein] which results in increased susceptibility to Arsenic Trioxide; [zinc protoporphyrin results in decreased activity of HMOX1] which results in decreased susceptibility to peoniflorin; zinc protoporphyrin analog inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron]; zinc protoporphyrin inhibits the reaction [[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in decreased abundance of Glutathione]]; zinc protoporphyrin inhibits the reaction [[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in increased abundance of Malondialdehyde]]; zinc protoporphyrin inhibits the reaction [[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] which results in decreased susceptibility to Ethanol]; zinc protoporphyrin inhibits the reaction [ALB protein results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Cilostazol results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [Cilostazol results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased activity of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Dexmedetomidine promotes the reaction [Ropivacaine results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]]; zinc protoporphyrin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of HMOX1 protein]; zinc protoporphyrin promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; zinc protoporphyrin results in decreased expression of and results in decreased activity of HMOX1 protein; zinc protoporphyrin results in increased expression of and results in decreased activity of HMOX1 protein
[zinc protoporphyrin co-treated with Hemin] results in increased expression of HMOX1 mRNA; [zinc protoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; ALB protein inhibits the reaction [zinc protoporphyrin results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [8-oxoberberine promotes the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HMOX1 mRNA]]; zinc protoporphyrin inhibits the reaction [8-oxoberberine promotes the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [[Lipopolysaccharides co-treated with 2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone] results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Cisplatin results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Glucose deficiency promotes the reaction [Simvastatin results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides]; zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Resveratrol inhibits the reaction [Doxorubicin results in decreased expression of and results in decreased activity of HMOX1 protein]]
[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of HMOX1 mRNA; [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with zinc protoporphyrin] results in increased expression of HMOX1 mRNA; [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]; [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [Resveratrol results in increased abundance of Glutathione]; [zinc protoporphyrin results in decreased activity of HMOX1 protein] which results in decreased susceptibility to Resveratrol; Hemin inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]]; Hemin inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Glucose results in decreased activity of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin promotes the reaction [Glucose results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Hemin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]]; zinc protoporphyrin inhibits the reaction [Hemin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides]; zinc protoporphyrin inhibits the reaction [lead acetate results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [olprinone results in increased activity of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Propofol inhibits the reaction [Glucose results in decreased activity of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Propofol promotes the reaction [Glucose results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Sildenafil Citrate results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [Sildenafil Citrate results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Tadalafil promotes the reaction [Cisplatin results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of HMOX1 protein]
zinc protoporphyrin results in increased expression of HMOX1 mRNA; zinc protoporphyrin results in increased expression of HMOX1 protein
zinc protoporphyrin results in decreased activity of HMOX1; zinc protoporphyrin results in decreased activity of HMOX1 protein
zinc protoporphyrin affects the expression of HMOX1 mRNA; zinc protoporphyrin affects the expression of HMOX1 protein
zinc protoporphyrin results in decreased expression of HMOX1 mRNA; zinc protoporphyrin results in decreased expression of HMOX1 protein
CTD PMID:7524564 PMID:12352873 PMID:14649057 PMID:15602829 PMID:16462769 More... NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Hmox2 heme oxygenase 2 decreases activity
decreases expression
EXP
ISO
zinc protoporphyrin results in decreased activity of HMOX2 protein
zinc protoporphyrin results in decreased expression of HMOX2 protein
CTD PMID:21448202 PMID:25824035 NCBI chr16:4,544,225...4,584,606
Ensembl chr16:4,544,225...4,584,606
JBrowse link
G Hp1bp3 heterochromatin protein 1, binding protein 3 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of HP1BP3 mRNA CTD PMID:22839698 NCBI chr 4:137,943,781...137,971,994
Ensembl chr 4:137,943,607...137,971,994
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 multiple interactions EXP zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased expression of HSD11B1 mRNA]] CTD PMID:27523796 NCBI chr 1:192,903,917...192,946,345
Ensembl chr 1:192,903,942...192,946,383
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO
EXP
zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]
zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]
zinc protoporphyrin promotes the reaction [Indomethacin results in increased expression of ICAM1 mRNA]
CTD PMID:19608869 PMID:23892052 PMID:33049506 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
JBrowse link
G Ifnb1 interferon beta 1, fibroblast multiple interactions EXP zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]] CTD PMID:20861358 NCBI chr 4:88,440,253...88,441,083
Ensembl chr 4:88,440,262...88,441,011
JBrowse link
G Ifng interferon gamma multiple interactions
increases expression
ISO zinc protoporphyrin inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased expression of HMOX1 protein]
zinc protoporphyrin results in increased expression of IFNG mRNA
CTD PMID:21295052 PMID:25780291 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
JBrowse link
G Il10 interleukin 10 multiple interactions ISO zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of IL10 mRNA]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of IL10 protein] CTD PMID:20056245 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
JBrowse link
G Il12b interleukin 12b multiple interactions EXP zinc protoporphyrin promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA]] CTD PMID:33049506 NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860
JBrowse link
G Il18 interleukin 18 multiple interactions ISO zinc protoporphyrin inhibits the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of IL18 protein]]; zinc protoporphyrin inhibits the reaction [Hemin results in decreased susceptibility to IL18 protein] CTD PMID:18215737 PMID:36858639 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO
EXP
zinc protoporphyrin inhibits the reaction [Cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; zinc protoporphyrin inhibits the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of IL1B protein]]
zinc protoporphyrin inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased expression of HMOX1 protein]; zinc protoporphyrin promotes the reaction [Indomethacin results in increased expression of IL1B mRNA]
zinc protoporphyrin results in increased expression of IL1B mRNA
zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; zinc protoporphyrin inhibits the reaction [8-oxoberberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL1B protein]]; zinc protoporphyrin inhibits the reaction [sesamol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]
CTD PMID:20131233 PMID:21295052 PMID:23892052 PMID:25780291 PMID:27523796 More... NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il23a interleukin 23, alpha subunit p19 multiple interactions EXP zinc protoporphyrin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased expression of IL23A mRNA]]; zinc protoporphyrin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL23A protein]] CTD PMID:33049506 NCBI chr10:128,132,009...128,133,953
Ensembl chr10:128,132,008...128,134,621
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO
EXP
zinc protoporphyrin inhibits the reaction [cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased expression of IL6 protein]]
zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; zinc protoporphyrin inhibits the reaction [8-oxoberberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; zinc protoporphyrin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]; zinc protoporphyrin inhibits the reaction [manganese chloride promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [sesamol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]
zinc protoporphyrin results in increased expression of IL6 mRNA
CTD PMID:19608869 PMID:20131233 PMID:21963524 PMID:25780291 PMID:27523796 More... NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D decreases expression ISO zinc protoporphyrin results in decreased expression of INPP5D protein CTD PMID:25780291 NCBI chr 1:87,548,034...87,648,232
Ensembl chr 1:87,548,034...87,648,229
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO zinc protoporphyrin promotes the reaction [IRAK1 protein binds to MYD88 protein] CTD PMID:25780291 NCBI chr  X:73,057,520...73,067,527
Ensembl chr  X:73,057,520...73,067,524
JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 decreases expression ISO zinc protoporphyrin results in decreased expression of IRAK3 protein CTD PMID:25780291 NCBI chr10:119,977,553...120,038,035
Ensembl chr10:119,977,553...120,038,035
JBrowse link
G Itgam integrin alpha M increases expression ISO zinc protoporphyrin results in increased expression of ITGAM protein CTD PMID:22118543 NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663
JBrowse link
G Jun jun proto-oncogene multiple interactions
increases expression
ISO zinc protoporphyrin promotes the reaction [arsenic trioxide results in increased expression of JUN protein]
zinc protoporphyrin results in increased expression of JUN protein
CTD PMID:27829220 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
JBrowse link
G Kcnab1 potassium voltage-gated channel, shaker-related subfamily, beta member 1 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of KCNAB1 mRNA CTD PMID:22839698 NCBI chr 3:64,856,636...65,285,643
Ensembl chr 3:64,856,617...65,285,644
JBrowse link
G Kctd20 potassium channel tetramerisation domain containing 20 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of KCTD20 mRNA CTD PMID:22839698 NCBI chr17:29,171,420...29,188,523
Ensembl chr17:29,170,924...29,188,523
JBrowse link
G Kidins220 kinase D-interacting substrate 220 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of KIDINS220 mRNA CTD PMID:22839698 NCBI chr12:25,024,909...25,113,151
Ensembl chr12:25,024,924...25,113,151
JBrowse link
G Kitl kit ligand multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of KITLG mRNA CTD PMID:22839698 NCBI chr10:99,851,477...99,936,278
Ensembl chr10:99,851,492...99,936,278
JBrowse link
G Kras Kirsten rat sarcoma viral oncogene homolog multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of KRAS mRNA CTD PMID:22839698 NCBI chr 6:145,162,425...145,197,631
Ensembl chr 6:145,162,425...145,195,965
JBrowse link
G Larp1b La ribonucleoprotein 1B multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of LARP1B mRNA CTD PMID:22839698 NCBI chr 3:40,904,198...40,994,642
Ensembl chr 3:40,904,263...40,994,669
JBrowse link
G Ldha lactate dehydrogenase A multiple interactions ISO zinc protoporphyrin inhibits the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of LDHA protein]] CTD PMID:36858639 NCBI chr 7:46,491,698...46,505,051
Ensembl chr 7:46,490,899...46,505,051
JBrowse link
G Lnx1 ligand of numb-protein X 1 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of LNX1 mRNA CTD PMID:22839698 NCBI chr 5:74,753,108...74,865,203
Ensembl chr 5:74,753,108...74,863,573
JBrowse link
G Lyrm7 LYR motif containing 7 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of LYRM7 mRNA CTD PMID:22839698 NCBI chr11:54,717,692...54,751,738
Ensembl chr11:54,717,692...54,751,742
JBrowse link
G Macf1 microtubule-actin crosslinking factor 1 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of MACF1 mRNA CTD PMID:22839698 NCBI chr 4:123,243,386...123,581,594
Ensembl chr 4:123,243,426...123,581,331
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
ISO
EXP
[zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [neferine inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]]
zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]]; zinc protoporphyrin promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; zinc protoporphyrin promotes the reaction [lipoteichoic acid results in increased phosphorylation of MAPK1 protein]; zinc protoporphyrin promotes the reaction [Peptidoglycan results in increased phosphorylation of MAPK1 protein]
zinc protoporphyrin results in increased phosphorylation of MAPK1 protein
CTD PMID:19376148 PMID:20523338 PMID:27523796 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
ISO
EXP
[zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [neferine inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]]
zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]]; zinc protoporphyrin promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; zinc protoporphyrin promotes the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein]; zinc protoporphyrin promotes the reaction [Peptidoglycan results in increased phosphorylation of MAPK3 protein]
zinc protoporphyrin results in increased phosphorylation of MAPK3 protein
CTD PMID:19376148 PMID:20523338 PMID:27523796 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mark2 MAP/microtubule affinity regulating kinase 2 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of MARK2 mRNA CTD PMID:22839698 NCBI chr19:7,252,761...7,319,222
Ensembl chr19:7,252,761...7,319,225
JBrowse link
G Mfn1 mitofusin 1 multiple interactions ISO Hemin inhibits the reaction [zinc protoporphyrin promotes the reaction [Lipopolysaccharides results in decreased expression of MFN1 mRNA]]; Hemin inhibits the reaction [zinc protoporphyrin promotes the reaction [Lipopolysaccharides results in decreased expression of MFN1 protein]]; zinc protoporphyrin inhibits the reaction [Hemin inhibits the reaction [Lipopolysaccharides results in decreased expression of MFN1 mRNA]]; zinc protoporphyrin inhibits the reaction [Hemin inhibits the reaction [Lipopolysaccharides results in decreased expression of MFN1 protein]]; zinc protoporphyrin promotes the reaction [Lipopolysaccharides results in decreased expression of MFN1 mRNA]; zinc protoporphyrin promotes the reaction [Lipopolysaccharides results in decreased expression of MFN1 protein] CTD PMID:27830717 NCBI chr 3:32,583,594...32,633,384
Ensembl chr 3:32,583,614...32,633,388
JBrowse link
G Mllt3 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of MLLT3 mRNA CTD PMID:22839698 NCBI chr 4:87,688,162...87,951,652
Ensembl chr 4:87,688,162...87,951,601
JBrowse link
G Mmp2 matrix metallopeptidase 2 affects expression
multiple interactions
ISO
EXP
zinc protoporphyrin affects the expression of MMP2
zinc protoporphyrin inhibits the reaction [fisetin results in decreased expression of MMP2 mRNA]; zinc protoporphyrin inhibits the reaction [fisetin results in decreased expression of MMP2 protein]
CTD PMID:23704825 PMID:30076913 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO
EXP
zinc protoporphyrin promotes the reaction [arsenic trioxide results in increased expression of MMP9 protein]
zinc protoporphyrin inhibits the reaction [fisetin results in decreased expression of MMP9 mRNA]; zinc protoporphyrin inhibits the reaction [fisetin results in decreased expression of MMP9 protein]
CTD PMID:27829220 PMID:30076913 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO zinc protoporphyrin promotes the reaction [Indomethacin results in increased activity of MPO protein]; zinc protoporphyrin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:17292349 PMID:23892052 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
JBrowse link
G Myd88 myeloid differentiation primary response gene 88 multiple interactions ISO zinc protoporphyrin promotes the reaction [IRAK1 protein binds to MYD88 protein]; zinc protoporphyrin promotes the reaction [TLR2 protein binds to MYD88 protein]; zinc protoporphyrin promotes the reaction [TLR4 protein binds to MYD88 protein]; zinc protoporphyrin promotes the reaction [TRAF6 protein binds to MYD88 protein] CTD PMID:25780291 NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein promotes the reaction [SRC protein binds to NCF1 protein]]] CTD PMID:19608869 NCBI chr 5:134,248,907...134,258,479
Ensembl chr 5:134,248,907...134,258,479
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions
affects expression
ISO zinc protoporphyrin inhibits the reaction [Hemin results in increased expression of NFE2L2 protein]
zinc protoporphyrin affects the expression of NFE2L2 mRNA; zinc protoporphyrin affects the expression of NFE2L2 protein
CTD PMID:23704825 PMID:25824035 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions EXP zinc protoporphyrin inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides affects the localization of [RELA protein binds to NFKB1 protein]]] CTD PMID:21925249 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO
EXP
zinc protoporphyrin inhibits the reaction [cilostazol results in increased expression of NFKBIA protein]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of NFKBIA protein]
zinc protoporphyrin inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]]
CTD PMID:20131233 PMID:21925249 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
JBrowse link
G Nos1 nitric oxide synthase 1, neuronal multiple interactions ISO [Sildenafil Citrate co-treated with zinc protoporphyrin] results in increased expression of NOS1 mRNA CTD PMID:17627722 NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP
ISO
[zinc protoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [Peptidoglycan results in increased expression of NOS2 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [zinc protoporphyrin inhibits the reaction [Peptidoglycan results in increased expression of NOS2 protein]]; lactacystin inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; lactacystin inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; lactacystin inhibits the reaction [zinc protoporphyrin inhibits the reaction [Peptidoglycan results in increased expression of NOS2 protein]]; pyrazolanthrone inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; pyrazolanthrone inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; pyrazolanthrone inhibits the reaction [zinc protoporphyrin inhibits the reaction [Peptidoglycan results in increased expression of NOS2 protein]]; zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; zinc protoporphyrin inhibits the reaction [Peptidoglycan results in increased expression of NOS2 protein]; zinc protoporphyrin inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]
[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of NOS2 mRNA; [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of NOS2 protein; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in decreased expression of NOS2 protein]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of NOS2 mRNA]]; zinc protoporphyrin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer inhibits the reaction [Ethanol results in increased expression of NOS2 mRNA]]; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of NOS2 mRNA]; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of NOS2 protein]
CTD PMID:19376148 PMID:20357190 PMID:21925249 PMID:26460608 PMID:26747958 More... NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Pde4dip phosphodiesterase 4D interacting protein (myomegalin) multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of PDE4DIP mRNA CTD PMID:22839698 NCBI chr 3:97,597,144...97,796,023
Ensembl chr 3:97,597,140...97,796,023
JBrowse link
G Pgf placental growth factor multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of PGF mRNA CTD PMID:22839698 NCBI chr12:85,213,413...85,224,087
Ensembl chr12:85,213,409...85,224,564
JBrowse link
G Polr3k polymerase (RNA) III (DNA directed) polypeptide K multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of POLR3K mRNA CTD PMID:22839698 NCBI chr 2:181,506,153...181,512,623
Ensembl chr 2:181,506,130...181,512,623
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions ISO zinc protoporphyrin inhibits the reaction [cilostazol results in increased activity of PPARG protein]; zinc protoporphyrin inhibits the reaction [rosiglitazone results in increased activity of PPARG protein] CTD PMID:21660147 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
JBrowse link
G Ppil1 peptidylprolyl isomerase (cyclophilin)-like 1 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of PPIL1 mRNA CTD PMID:22839698 NCBI chr17:29,469,809...29,482,945
Ensembl chr17:29,469,777...29,483,160
JBrowse link
G Prdx2 peroxiredoxin 2 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of PRDX2 mRNA CTD PMID:22839698 NCBI chr 8:85,696,251...85,701,440
Ensembl chr 8:85,696,216...85,701,463
JBrowse link
G Prr11 proline rich 11 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of PRR11 mRNA CTD PMID:22839698 NCBI chr11:86,979,982...86,999,540
Ensembl chr11:86,979,979...86,999,534
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
zinc protoporphyrin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer inhibits the reaction [F2 protein results in increased expression of PTGS2 protein]]; zinc protoporphyrin promotes the reaction [arsenic trioxide results in increased expression of PTGS2]
zinc protoporphyrin inhibits the reaction [sesamol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]; zinc protoporphyrin promotes the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
CTD PMID:23649692 PMID:24003391 PMID:26385185 PMID:30261164 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Ptpn12 protein tyrosine phosphatase, non-receptor type 12 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of PTPN12 mRNA CTD PMID:22839698 NCBI chr 5:21,191,643...21,261,009
Ensembl chr 5:21,191,643...21,260,909
JBrowse link
G Ptpro protein tyrosine phosphatase receptor type O multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of PTPRO mRNA CTD PMID:22839698 NCBI chr 6:137,229,189...137,440,251
Ensembl chr 6:137,229,317...137,440,231
JBrowse link
G Rap2c RAP2C, member of RAS oncogene family multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of RAP2C mRNA CTD PMID:22839698 NCBI chr  X:50,093,163...50,108,966
Ensembl chr  X:50,092,789...50,106,895
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO
EXP
zinc protoporphyrin inhibits the reaction [cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]]; zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased expression of RELA mRNA]]; zinc protoporphyrin promotes the reaction [quinocetone results in increased expression of RELA mRNA]
zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased localization of and results in increased activity of RELA protein]]; zinc protoporphyrin inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides affects the localization of [RELA protein binds to NFKB1 protein]]]; zinc protoporphyrin inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein modified form]]
zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in decreased expression of RELA protein]
CTD PMID:19608869 PMID:20131233 PMID:20357190 PMID:21925249 PMID:27375190 More... NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Rgcc regulator of cell cycle multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of RGCC mRNA CTD PMID:22839698 NCBI chr14:79,526,190...79,539,075
Ensembl chr14:79,526,196...79,539,085
JBrowse link
G Rsph10b radial spoke head 10 homolog B (Chlamydomonas) multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of RSPH10B2 mRNA CTD PMID:22839698 Ensembl chr 5:143,869,853...143,922,537 JBrowse link
G Scaf11 SR-related CTD-associated factor 11 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of SCAF11 mRNA CTD PMID:22839698 NCBI chr15:96,309,580...96,358,695
Ensembl chr15:96,309,580...96,358,724
JBrowse link
G Scamp1 secretory carrier membrane protein 1 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of SCAMP1 mRNA CTD PMID:22839698 NCBI chr13:94,337,818...94,422,339
Ensembl chr13:94,337,818...94,422,365
JBrowse link
G Sec23b SEC23 homolog B, COPII coat complex component multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of SEC23B mRNA CTD PMID:22839698 NCBI chr 2:144,398,165...144,432,673
Ensembl chr 2:144,398,149...144,432,669
JBrowse link
G Sel1l sel-1 suppressor of lin-12-like (C. elegans) multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of SEL1L mRNA CTD PMID:22839698 NCBI chr12:91,772,817...91,815,931
Ensembl chr12:91,772,817...91,815,931
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO zinc protoporphyrin inhibits the reaction [Fenofibrate results in increased expression of SIRT1 protein] CTD PMID:34520103 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483
JBrowse link
G Slc22a3 solute carrier family 22 (organic cation transporter), member 3 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of SLC22A3 mRNA CTD PMID:22839698 NCBI chr17:12,638,859...12,726,591
Ensembl chr17:12,637,847...12,726,591
JBrowse link
G Slc35e1 solute carrier family 35, member E1 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of SLC35E1 mRNA CTD PMID:22839698 NCBI chr 8:73,231,839...73,246,473
Ensembl chr 8:73,234,485...73,246,458
JBrowse link
G Smcr8 Smith-Magenis syndrome chromosome region, candidate 8 homolog (human) multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of SMCR8 mRNA CTD PMID:22839698 NCBI chr11:60,668,351...60,679,113
Ensembl chr11:60,668,350...60,679,113
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of SOD2 mRNA; zinc protoporphyrin inhibits the reaction [HIF1A protein results in increased activity of SOD2 protein] CTD PMID:17066447 PMID:22839698 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link
G Sptbn1 spectrin beta, non-erythrocytic 1 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of SPTBN1 mRNA CTD PMID:22839698 NCBI chr11:30,049,395...30,218,384
Ensembl chr11:30,049,395...30,218,175
JBrowse link
G Src Rous sarcoma oncogene multiple interactions ISO zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein promotes the reaction [SRC protein binds to NCF1 protein]]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein promotes the reaction [SRC protein binds to TNFRSF1A protein]]] CTD PMID:19608869 NCBI chr 2:157,265,828...157,313,758
Ensembl chr 2:157,260,364...157,313,782
JBrowse link
G Ssbp3 single-stranded DNA binding protein 3 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of SSBP3 mRNA CTD PMID:22839698 NCBI chr 4:106,768,667...106,906,891
Ensembl chr 4:106,767,898...106,906,891
JBrowse link
G St3gal1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of ST3GAL1 mRNA CTD PMID:22839698 NCBI chr15:66,974,724...67,048,575
Ensembl chr15:66,974,724...67,048,679
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO zinc protoporphyrin inhibits the reaction [Ozone results in increased phosphorylation of STAT1 protein] CTD PMID:19061877 NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO
EXP
zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Glucose results in decreased phosphorylation of STAT3 protein]]; zinc protoporphyrin inhibits the reaction [Propofol inhibits the reaction [Glucose results in decreased phosphorylation of STAT3 protein]]
zinc protoporphyrin inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]
CTD PMID:24095726 PMID:24810525 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
JBrowse link
G Tgfb1 transforming growth factor, beta 1 affects expression
increases expression
decreases secretion
ISO zinc protoporphyrin affects the expression of TGFB1
zinc protoporphyrin results in increased expression of TGFB1 protein
zinc protoporphyrin results in decreased secretion of TGFB1 protein
CTD PMID:21163135 PMID:23525258 PMID:23704825 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 affects expression
multiple interactions
ISO zinc protoporphyrin affects the expression of TIMP1
zinc protoporphyrin promotes the reaction [ALB protein results in increased expression of TIMP1 protein]
CTD PMID:21163135 PMID:23704825 NCBI chr  X:20,736,524...20,740,972
Ensembl chr  X:20,736,405...20,740,974
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO zinc protoporphyrin promotes the reaction [TLR2 protein binds to MYD88 protein] CTD PMID:25780291 NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO zinc protoporphyrin promotes the reaction [TLR4 protein binds to MYD88 protein] CTD PMID:25780291 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
zinc protoporphyrin inhibits the reaction [cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; zinc protoporphyrin inhibits the reaction [cilostazol results in decreased susceptibility to TNF protein]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein promotes the reaction [SRC protein binds to NCF1 protein]]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein promotes the reaction [SRC protein binds to TNFRSF1A protein]]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]]
zinc protoporphyrin inhibits the reaction [8-oxoberberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of TNF protein]]; zinc protoporphyrin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; zinc protoporphyrin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased localization of and results in increased activity of RELA protein]]; zinc protoporphyrin inhibits the reaction [manganese chloride promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]]; zinc protoporphyrin inhibits the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; zinc protoporphyrin inhibits the reaction [sesamol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; zinc protoporphyrin inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]
[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of TNF mRNA; [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of TNF protein; zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; zinc protoporphyrin inhibits the reaction [naringenin results in decreased activity of TNF protein]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of TNF protein]]; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of TNF mRNA]; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of TNF protein]
CTD PMID:19608869 PMID:20052772 PMID:20131233 PMID:21660147 PMID:21925249 More... NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a multiple interactions ISO zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein promotes the reaction [SRC protein binds to TNFRSF1A protein]]] CTD PMID:19608869 NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447
JBrowse link
G Tnrc6a trinucleotide repeat containing 6a multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of TNRC6A mRNA CTD PMID:22839698 NCBI chr 7:122,630,324...122,794,519
Ensembl chr 7:122,723,108...122,794,519
JBrowse link
G Tollip toll interacting protein decreases expression ISO zinc protoporphyrin results in decreased expression of TOLLIP protein CTD PMID:25780291 NCBI chr 7:141,435,317...141,456,198
Ensembl chr 7:141,428,550...141,472,244
JBrowse link
G Traf6 TNF receptor-associated factor 6 multiple interactions ISO zinc protoporphyrin promotes the reaction [TRAF6 protein binds to MYD88 protein] CTD PMID:25780291 NCBI chr 2:101,508,765...101,532,013
Ensembl chr 2:101,508,774...101,532,014
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO
EXP
[zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [cobaltiprotoporphyrin results in increased expression of TP53 protein]
zinc protoporphyrin inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of TRP53 protein]]
zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in decreased expression of TP53 protein]
CTD PMID:18042465 PMID:20357190 PMID:22763982 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Ubxn2a UBX domain protein 2A multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of UBXN2A mRNA CTD PMID:22839698 NCBI chr12:4,926,814...4,957,749
Ensembl chr12:4,929,032...4,957,705
JBrowse link
G Usp13 ubiquitin specific peptidase 13 (isopeptidase T-3) multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of USP13 mRNA CTD PMID:22839698 NCBI chr 3:32,870,432...32,992,224
Ensembl chr 3:32,871,695...32,992,220
JBrowse link
G Usp34 ubiquitin specific peptidase 34 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of USP34 mRNA CTD PMID:22839698 NCBI chr11:23,256,433...23,440,560
Ensembl chr11:23,256,895...23,440,560
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO
EXP
zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]]
zinc protoporphyrin promotes the reaction [Indomethacin results in increased expression of VCAM1 mRNA]
CTD PMID:19608869 PMID:23892052 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337
JBrowse link
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor affects abundance ISO VDR gene polymorphism affects the abundance of zinc protoporphyrin CTD PMID:25963508 NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511
JBrowse link
G Vps33a VPS33A CORVET/HOPS core subunit multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of VPS33A mRNA CTD PMID:22839698 NCBI chr 5:123,666,820...123,711,104
Ensembl chr 5:123,666,722...123,711,101
JBrowse link
G Wsb2 WD repeat and SOCS box-containing 2 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of WSB2 mRNA CTD PMID:22839698 NCBI chr 5:117,495,370...117,516,666
Ensembl chr 5:117,495,369...117,516,666
JBrowse link
G Zfp36 zinc finger protein 36 multiple interactions EXP zinc protoporphyrin inhibits the reaction [[Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of ZFP36 mRNA]; zinc protoporphyrin inhibits the reaction [Hemin results in increased expression of ZFP36 mRNA]; zinc protoporphyrin inhibits the reaction [Nicotine results in increased expression of ZFP36 mRNA] CTD PMID:24095726 NCBI chr 7:28,076,208...28,078,680
Ensembl chr 7:28,076,209...28,079,678
JBrowse link
G Zfp827 zinc finger protein 827 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in increased expression of ZNF827 mRNA CTD PMID:22839698 NCBI chr 8:79,753,754...79,920,397
Ensembl chr 8:79,755,066...79,920,395
JBrowse link
G Zfyve16 zinc finger, FYVE domain containing 16 multiple interactions ISO [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of ZFYVE16 mRNA CTD PMID:22839698 NCBI chr13:92,624,257...92,667,318
Ensembl chr13:92,623,616...92,667,376
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      biological role 22162
        biochemical role 21431
          cofactor 16825
            porphyrins 376
              metalloporphyrin 337
                metalloprotoporphyrin 337
                  zinc protoporphyrin 156
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            organic molecule 21647
                              organic cyclic compound 21252
                                organic heterocyclic compound 20352
                                  organonitrogen heterocyclic compound 19099
                                    polypyrrole 705
                                      tetrapyrrole 593
                                        cyclic tetrapyrrole 461
                                          porphyrins 376
                                            metalloporphyrin 337
                                              metalloprotoporphyrin 337
                                                zinc protoporphyrin 156
paths to the root