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ONTOLOGY REPORT - ANNOTATIONS


Term:liquiritigenin
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Accession:CHEBI:28777 term browser browse the term
Definition:A dihydroxyflavanone compound having the two hydroxy substituents at the 4'- and 7-positions. Isolated from the root of Glycyrrhizae uralensis, it is a selective agonist for oestrogen receptor beta.
Synonyms:exact_synonym: (2S)-7-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one
 related_synonym: (2S)-7-Hydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one;   (2S)-liquiritigenin;   4',7-Dihydroxyflavanone;   7-HYDROXY-2-(4-HYDROXY-PHENYL)-CHROMAN-4-ONE;   Formula=C15H12O4;   InChI=1S/C15H12O4/c16-10-3-1-9(2-4-10)14-8-13(18)12-6-5-11(17)7-15(12)19-14/h1-7,14,16-17H,8H2/t14-/m0/s1;   InChIKey=FURUXTVZLHCCNA-AWEZNQCLSA-N;   SMILES=Oc1ccc(cc1)[C@@H]1CC(=O)c2ccc(O)cc2O1
 alt_id: CHEBI:25065;   CHEBI:42001;   CHEBI:6501
 xref: Beilstein:3593780 "Beilstein";   CAS:578-86-9 "ChemIDplus";   CAS:578-86-9 "KEGG COMPOUND";   HMDB:HMDB0029519;   KEGG:C09762;   KNApSAcK:C00000977;   LIPID_MAPS_instance:LMPK12140061 "LIPID MAPS"
 xref_mesh: MESH:C083152
 xref: PDBeChem:DFV;   PMID:17950610 "ChEMBL";   PMID:18177995 "Europe PMC";   PMID:21866899 "Europe PMC";   Reaxys:3593780 "Reaxys";   Wikipedia:Liquiritigenin


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liquiritigenin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cxcl12 C-X-C motif chemokine ligand 12 JBrowse link 4 149,261,044 149,273,891 RGD:6480464
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 JBrowse link 1 147,713,879 147,814,410 RGD:6480464
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:6480464
G Esr2 estrogen receptor 2 JBrowse link 6 99,163,953 99,214,711 RGD:6480464
G Gclc glutamate-cysteine ligase, catalytic subunit JBrowse link 8 85,059,051 85,097,471 RGD:6480464
G Gclm glutamate cysteine ligase, modifier subunit JBrowse link 2 225,827,504 225,847,876 RGD:6480464
G Gsr glutathione-disulfide reductase JBrowse link 16 62,197,617 62,239,987 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:6480464
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:6480464
G Trpm3 transient receptor potential cation channel, subfamily M, member 3 JBrowse link 1 239,741,572 240,757,583 RGD:6480464
G Tsc22d3 TSC22 domain family, member 3 JBrowse link X 111,884,285 111,944,693 RGD:6480464
G Txn2 thioredoxin 2 JBrowse link 7 119,144,350 119,158,173 RGD:6480464
G Txnrd2 thioredoxin reductase 2 JBrowse link 11 86,667,994 86,716,063 RGD:6480464
liquiritin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 1 213,511,892 213,522,195 RGD:6480464
G Gclc glutamate-cysteine ligase, catalytic subunit JBrowse link 8 85,059,051 85,097,471 RGD:6480464
G Gclm glutamate cysteine ligase, modifier subunit JBrowse link 2 225,827,504 225,847,876 RGD:6480464
G Gsr glutathione-disulfide reductase JBrowse link 16 62,197,617 62,239,987 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:6480464
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:6480464
G Txn2 thioredoxin 2 JBrowse link 7 119,144,350 119,158,173 RGD:6480464
G Txnrd2 thioredoxin reductase 2 JBrowse link 11 86,667,994 86,716,063 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19657
    role 19601
      biological role 19599
        pharmacological role 18680
          agonist 18011
            hormone agonist 2727
              liquiritigenin 18
                liquiritin 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19657
    subatomic particle 19653
      composite particle 19653
        hadron 19653
          baryon 19653
            nucleon 19653
              atomic nucleus 19653
                atom 19653
                  main group element atom 19534
                    p-block element atom 19534
                      carbon group element atom 19417
                        carbon atom 19409
                          organic molecular entity 19409
                            organic molecule 19332
                              organic cyclic compound 19083
                                organic heterocyclic compound 18154
                                  oxacycle 16940
                                    benzopyran 9429
                                      1-benzopyran 9121
                                        flavonoid 6244
                                          flavans 2847
                                            flavanones 291
                                              hydroxyflavanone 277
                                                4'-hydroxyflavanones 251
                                                  4',7-dihydroxyflavanone 18
                                                    liquiritigenin 18
                                                      liquiritin 11
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.