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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:norlaudanosoline
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Accession:CHEBI:28770 term browser browse the term
Definition:An isoquinolinol that has formula C16H17NO4.
Synonyms:exact_synonym: 1-(3,4-dihydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol
 related_synonym: (R,S)-Norlaudanosoline;   Formula=C16H17NO4;   InChI=1S/C16H17NO4/c18-13-2-1-9(6-14(13)19)5-12-11-8-16(21)15(20)7-10(11)3-4-17-12/h1-2,6-8,12,17-21H,3-5H2;   InChIKey=ABXZOXDTHTTZJW-UHFFFAOYSA-N;   SMILES=Oc1ccc(CC2NCCc3cc(O)c(O)cc23)cc1O;   Tetrahydropapaveroline
 alt_id: CHEBI:18715;   CHEBI:362
 xref: Beilstein:313061;   CAS:4747-99-3;   KEGG:C06350
 xref_mesh: MESH:D013765


show annotations for term's descendants           Sort by:
norlaudanosoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation EXP Tetrahydropapaveroline increases phosphorylation of Akt1 protein in PC12 cells RGD PMID:15082072 RGD:407445977 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions EXP [[CVT-10216 results in decreased activity of ALDH2 protein] which results in increased abundance of Tetrahydropapaveroline] inhibits the reaction [Cocaine results in increased abundance of and results in increased secretion of Dopamine]; [ALDH2 protein affects the abundance of Tetrahydropapaveroline] which affects the susceptibility to Cocaine; [CVT-10216 results in decreased activity of ALDH2 protein] which results in increased abundance of Tetrahydropapaveroline CTD PMID:20729865 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Tetrahydropapaveroline inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Tetrahydropapaveroline inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:8186192 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Tetrahydropapaveroline inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:8186192 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Tetrahydropapaveroline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Tetrahydropapaveroline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:8186192 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19893
      biological role 19891
        biochemical role 19598
          metabolite 19585
            alkaloid 8013
              isoquinoline alkaloid 1200
                benzylisoquinoline alkaloid 221
                  norlaudanosoline 5
                    (R)-norlaudanosoline + 0
                    (S)-norlaudanosoline + 0
                    6-O-methylnorlaudanosoline 0
                    laudanine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19865
                    p-block element atom 19865
                      carbon group element atom 19804
                        carbon atom 19801
                          organic molecular entity 19801
                            organic molecule 19754
                              organic cyclic compound 19544
                                organic heterocyclic compound 18909
                                  organonitrogen heterocyclic compound 18184
                                    isoquinolines 534
                                      isoquinolinol 47
                                        norlaudanosoline 5
                                          (R)-norlaudanosoline + 0
                                          (S)-norlaudanosoline + 0
                                          6-O-methylnorlaudanosoline 0
                                          laudanine + 0
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