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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:norlaudanosoline
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Accession:CHEBI:28770 term browser browse the term
Definition:An isoquinolinol that has formula C16H17NO4.
Synonyms:exact_synonym: 1-(3,4-dihydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol
 related_synonym: (R,S)-Norlaudanosoline;   Formula=C16H17NO4;   InChI=1S/C16H17NO4/c18-13-2-1-9(6-14(13)19)5-12-11-8-16(21)15(20)7-10(11)3-4-17-12/h1-2,6-8,12,17-21H,3-5H2;   InChIKey=ABXZOXDTHTTZJW-UHFFFAOYSA-N;   SMILES=Oc1ccc(CC2NCCc3cc(O)c(O)cc23)cc1O;   Tetrahydropapaveroline
 alt_id: CHEBI:18715;   CHEBI:362
 xref: Beilstein:313061;   CAS:4747-99-3;   KEGG:C06350
 xref_mesh: MESH:D013765


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norlaudanosoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions EXP [[CVT-10216 results in decreased activity of ALDH2 protein] which results in increased abundance of Tetrahydropapaveroline] inhibits the reaction [Cocaine results in increased abundance of and results in increased secretion of Dopamine]; [ALDH2 protein affects the abundance of Tetrahydropapaveroline] which affects the susceptibility to Cocaine; [CVT-10216 results in decreased activity of ALDH2 protein] which results in increased abundance of Tetrahydropapaveroline CTD PMID:20729865 NCBI chr12:34,949,549...34,982,527 JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Tetrahydropapaveroline inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Tetrahydropapaveroline inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:8186192 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Tetrahydropapaveroline inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:8186192 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Tetrahydropapaveroline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Tetrahydropapaveroline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:8186192 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        biochemical role 19389
          metabolite 19364
            alkaloid 5680
              isoquinoline alkaloid 1136
                benzylisoquinoline alkaloid 216
                  norlaudanosoline 4
                    (R)-norlaudanosoline + 0
                    (S)-norlaudanosoline + 0
                    6-O-methylnorlaudanosoline 0
                    laudanine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic molecule 19569
                              organic cyclic compound 19360
                                organic heterocyclic compound 18591
                                  organonitrogen heterocyclic compound 17643
                                    isoquinolines 445
                                      isoquinolinol 37
                                        norlaudanosoline 4
                                          (R)-norlaudanosoline + 0
                                          (S)-norlaudanosoline + 0
                                          6-O-methylnorlaudanosoline 0
                                          laudanine + 0
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