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ONTOLOGY REPORT - ANNOTATIONS


Term:aspartame
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Accession:CHEBI:2877 term browser browse the term
Definition:A dipeptide obtained by formal condensation of the alpha-carboxy group of L-aspartic acid with the amino group of methyl L-phenylalaninate. Commonly used as an artificial sweetener.
Synonyms:exact_synonym: methyl L-alpha-aspartyl-L-phenylalaninate
 related_synonym: 1-methyl N-L-alpha-aspartyl-L-phenylalanate;   3-Amino-N-(alpha-carboxyphenethyl)succinamic acid N-methyl ester;   3-Amino-N-(alpha-methoxycarbonylphenethyl) succinamic acid;   AminoSweet;   Asp-phe-ome;   Aspartylphenylalanine methyl ester;   E 951;   Formula=C14H18N2O5;   InChI=1S/C14H18N2O5/c1-21-14(20)11(7-9-5-3-2-4-6-9)16-13(19)10(15)8-12(17)18/h2-6,10-11H,7-8,15H2,1H3,(H,16,19)(H,17,18)/t10-,11-/m0/s1;   InChIKey=IAOZJIPTCAWIRG-QWRGUYRKSA-N;   L-Aspartyl-L-phenylalanine methyl ester;   NutraSweet;   SMILES=C(C[C@@H](C(N[C@@H](CC1=CC=CC=C1)C(=O)OC)=O)N)(=O)O;   Sanecta;   aspartam;   aspartamo;   aspartamum
 alt_id: CHEBI:45047
 xref: Beilstein:2223850 "Beilstein";   CAS:22839-47-0 "ChemIDplus";   CAS:22839-47-0 "KEGG COMPOUND";   DrugBank:DB00168;   HMDB:HMDB0001894;   KEGG:C11045;   KEGG:D02381
 xref_mesh: MESH:D001218
 xref: MetaCyc:CPD-5583;   PDBeChem:PME;   PMID:1771173 "Europe PMC";   PMID:2013754 "Europe PMC";   PMID:21150094 "Europe PMC";   PMID:21372000 "Europe PMC";   PMID:22354473 "Europe PMC";   PMID:24355796 "Europe PMC";   PMID:24925367 "Europe PMC";   PMID:24944748 "Europe PMC";   PMID:24965331 "Europe PMC";   PMID:25431414 "Europe PMC";   PMID:25543075 "Europe PMC";   PMID:25786106 "Europe PMC";   PMID:25951455 "Europe PMC";   PMID:25991916 "Europe PMC";   PMID:26015492 "Europe PMC";   PMID:26099025 "Europe PMC";   PMID:26159964 "Europe PMC";   PMID:26247507 "Europe PMC";   PMID:26308194 "Europe PMC";   PMID:26321723 "Europe PMC";   PMID:26377607 "Europe PMC";   PMID:26582819 "Europe PMC";   PMID:26593524 "Europe PMC";   PMID:26912665 "Europe PMC";   PMID:27015640 "Europe PMC";   PMID:27038223 "Europe PMC";   PMID:27088715 "Europe PMC";   PMID:27127997 "Europe PMC";   PMID:27216413 "Europe PMC";   PMID:27298583 "Europe PMC";   PMID:27492574 "Europe PMC";   PMID:27565676 "Europe PMC";   PMID:27614095 "Europe PMC";   PMID:27640132 "Europe PMC";   PMID:27699780 "Europe PMC";   PMID:27728881 "Europe PMC";   PMID:27840415 "Europe PMC";   PMID:27845306 "Europe PMC";   Patent:US3492131;   Reaxys:2223850 "Reaxys";   Wikipedia:Aspartame


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aspartame term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ache acetylcholinesterase JBrowse link 12 22,472,358 22,477,052 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 JBrowse link 7 99,142,431 99,183,540 RGD:6480464
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 JBrowse link 1 83,103,925 83,119,578 RGD:6480464
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 1 213,511,892 213,522,195 RGD:6480464
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 JBrowse link 12 18,679,809 18,709,397 RGD:6480464
G F2 coagulation factor II JBrowse link 3 80,529,468 80,542,993 RGD:6480464
G Gsr glutathione-disulfide reductase JBrowse link 16 62,197,617 62,239,987 RGD:6480464
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:6480464
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:6480464
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6480464
G Npy neuropeptide Y JBrowse link 4 79,557,856 79,565,059 RGD:6480464
G Pomc proopiomelanocortin JBrowse link 6 28,382,937 28,388,771 RGD:6480464
G Slc15a1 solute carrier family 15 member 1 JBrowse link 15 106,800,081 106,844,668 RGD:6480464
G Tas1r2 taste 1 receptor member 2 JBrowse link 5 158,119,894 158,135,733 RGD:6480464
G Tas1r3 taste 1 receptor member 3 JBrowse link 5 173,307,325 173,312,950 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 JBrowse link 10 59,799,123 59,824,208 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        xenobiotic 18178
          aspartame 29
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    main group molecular entity 19545
                      s-block molecular entity 19329
                        hydrogen molecular entity 19319
                          hydrides 18242
                            organic hydride 17528
                              organic fundamental parent 17528
                                hydrocarbon 16935
                                  cyclic hydrocarbon 15098
                                    monocyclic hydrocarbon 5631
                                      annulene 5447
                                        aromatic annulene 5447
                                          benzene 5447
                                            alkylbenzene 3187
                                              methylbenzene 3048
                                                toluene 2909
                                                  benzyl group 2351
                                                    phenylalanine 2351
                                                      L-phenylalanine 2096
                                                        L-phenylalanine derivative 2085
                                                          methyl L-phenylalaninate 29
                                                            aspartame 29
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.