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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:p-cymene
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Accession:CHEBI:28768 term browser browse the term
Definition:A monoterpene that is toluene substituted by an isopropyl group at position 4.
Synonyms:related_synonym: 1-isopropyl-4-methylbenzene;   1-methyl-4-(1-methylethyl)benzene;   1-methyl-4-isopropylbenzene;   1-methyl-4-propan-2-yl-benzene;   4-Isopropyltoluene;   4-cymene;   Cymene;   Formula=C10H14;   InChI=1S/C10H14/c1-8(2)10-6-4-9(3)5-7-10/h4-8H,1-3H3;   InChIKey=HFPZCAJZSCWRBC-UHFFFAOYSA-N;   Isopropyltoluene;   Para-cymene;   SMILES=CC(C)c1ccc(C)cc1;   p-cimene;   p-cymol;   p-isopropyltoluene;   p-methylcumene;   p-methylisopropylbenzene
 alt_id: CHEBI:10624;   CHEBI:25825
 xref: BPDB:2018;   Beilstein:1903377;   CAS:99-87-6;   Gmelin:305912;   HMDB:HMDB0005805;   KEGG:C06575;   KNApSAcK:C00003040;   LIPID_MAPS_instance:LMPR0102090014
 xref_mesh: MESH:C007210
 xref: MetaCyc:CPD-1001;   PMID:11341314;   PMID:15508832;   PMID:17826989;   PMID:19040104;   PMID:24023812;   PMID:24421258;   Reaxys:1903377;   UM-BBD_compID:c0375;   Wikipedia:P-cymene


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p-cymene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO 4-cymene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; [4-cymene co-treated with beta-pinene co-treated with gamma-terpinene co-treated with cuminol] results in increased activity of AHR protein; [4-cymene co-treated with gamma-terpinene co-treated with Thymol co-treated with carvacrol] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; [4-cymene co-treated with gamma-terpinene co-treated with Thymol co-treated with carvacrol] results in increased activity of AHR protein; [4-cymene co-treated with gamma-terpinene co-treated with Thymol] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; [4-cymene co-treated with gamma-terpinene co-treated with Thymol] results in increased activity of AHR protein CTD PMID:29191726 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO 4-cymene inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:29191726 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
carvacrol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity
EXP [propiconazole co-treated with carvacrol] results in decreased activity of ACHE protein
carvacrol results in decreased activity of ACHE protein
CTD PMID:29852196 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions EXP carvacrol inhibits the reaction [Poloxamer results in decreased secretion of ADIPOQ protein]; carvacrol promotes the reaction [Simvastatin inhibits the reaction [Poloxamer results in decreased secretion of ADIPOQ protein]] CTD PMID:29071762 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases activity
ISO [4-cymene co-treated with gamma-terpinene co-treated with Thymol co-treated with carvacrol] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; [4-cymene co-treated with gamma-terpinene co-treated with Thymol co-treated with carvacrol] results in increased activity of AHR protein; carvacrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
carvacrol results in increased activity of AHR protein
CTD PMID:29191726 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO
EXP
carvacrol results in increased activity of CASP3 protein
carvacrol inhibits the reaction [Poloxamer results in increased expression of CASP3 protein]; carvacrol inhibits the reaction [propiconazole results in increased expression of CASP3 protein]; carvacrol inhibits the reaction [Simvastatin promotes the reaction [Poloxamer results in increased expression of CASP3 protein]]
CTD PMID:23146755 PMID:29071762 PMID:29852196 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions EXP carvacrol inhibits the reaction [Poloxamer results in decreased activity of CAT protein]; carvacrol inhibits the reaction [propiconazole results in decreased activity of CAT protein]; carvacrol promotes the reaction [Simvastatin inhibits the reaction [Poloxamer results in decreased activity of CAT protein]] CTD PMID:29071762 PMID:29852196 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP carvacrol inhibits the reaction [Poloxamer results in increased secretion of CKM protein]; carvacrol inhibits the reaction [Simvastatin results in increased secretion of CKM protein] CTD PMID:29071762 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [irinotecan results in increased expression of CXCL1 protein]]; carvacrol inhibits the reaction [irinotecan results in increased expression of CXCL1 protein] CTD PMID:27838229 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO carvacrol results in increased expression of CYP1A1 mRNA
carvacrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
CTD PMID:29191726 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Egfr epidermal growth factor receptor increases phosphorylation
multiple interactions
ISO carvacrol results in increased phosphorylation of EGFR protein
KN 93 inhibits the reaction [carvacrol results in increased phosphorylation of EGFR protein]; TRPV3 protein affects the reaction [carvacrol results in increased phosphorylation of EGFR protein]
CTD PMID:32535744 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP carvacrol inhibits the reaction [propiconazole results in increased expression of GFAP protein] CTD PMID:29852196 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A increases activity ISO carvacrol results in increased activity of HTR3A protein CTD PMID:26456648 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [irinotecan results in increased expression of IL1B protein]]; carvacrol inhibits the reaction [irinotecan results in increased expression of IL1B protein] CTD PMID:27838229 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Lep leptin multiple interactions EXP carvacrol inhibits the reaction [Poloxamer results in increased secretion of LEP protein] CTD PMID:29071762 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Mb myoglobin multiple interactions EXP carvacrol inhibits the reaction [Poloxamer results in increased secretion of MB protein] CTD PMID:29071762 NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [irinotecan results in increased activity of MPO protein]]; carvacrol inhibits the reaction [irinotecan results in increased activity of MPO protein] CTD PMID:27838229 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO carvacrol inhibits the reaction [irinotecan results in increased expression of NFKB1 protein] CTD PMID:27838229 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha multiple interactions
increases phosphorylation
ISO Erlotinib Hydrochloride inhibits the reaction [carvacrol results in increased phosphorylation of PIK3CA protein]; TRPV3 protein affects the reaction [carvacrol results in increased phosphorylation of PIK3CA protein] CTD PMID:32535744 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
carvacrol inhibits the reaction [irinotecan results in increased expression of PTGS2 protein]
carvacrol inhibits the reaction [propiconazole results in increased expression of PTGS2 protein]
CTD PMID:27838229 PMID:29852196 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases phosphorylation
ISO Erlotinib Hydrochloride inhibits the reaction [carvacrol results in increased phosphorylation of RELA protein]; TRPV3 protein affects the reaction [carvacrol results in increased phosphorylation of RELA protein] CTD PMID:32535744 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tgfa transforming growth factor alpha increases secretion
multiple interactions
ISO carvacrol results in increased secretion of TGFA protein
KN 93 inhibits the reaction [carvacrol results in increased secretion of TGFA protein]
CTD PMID:32535744 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [irinotecan results in increased expression of TNF protein]]; carvacrol inhibits the reaction [irinotecan results in increased expression of TNF protein] CTD PMID:27838229 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity EXP
ISO
carvacrol results in increased activity of TRPA1 protein CTD PMID:16617338 PMID:22935519 NCBI chr 5:4,379,999...4,433,243
Ensembl chr 5:4,379,999...4,433,570
JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 increases activity
affects response to substance
multiple interactions
increases response to substance
ISO
EXP
carvacrol results in increased activity of TRPV3 protein
TRPV3 protein affects the susceptibility to carvacrol
TRPV3 protein affects the reaction [carvacrol results in increased phosphorylation of EGFR protein]; TRPV3 protein affects the reaction [carvacrol results in increased phosphorylation of PIK3CA protein]; TRPV3 protein affects the reaction [carvacrol results in increased phosphorylation of RELA protein]
TRPV3 protein results in increased susceptibility to carvacrol
[carvacrol results in increased activity of TRPV3 protein] which results in increased transport of Calcium
[carvacrol binds to and results in increased activity of TRPV3 protein] which results in increased transport of Calcium; [carvacrol results in increased activity of TRPV3 protein] which results in increased transport of Calcium; carvacrol binds to and results in increased activity of TRPV3 protein; Ruthenium Red inhibits the reaction [[carvacrol binds to and results in increased activity of TRPV3 protein] which results in increased transport of Calcium]
CTD PMID:16617338 PMID:20086034 PMID:29658714 PMID:32535744 NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296
JBrowse link
tea tree oil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Tea Tree Oil inhibits the reaction [Testosterone results in increased activity of AR protein] CTD PMID:31393563 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Ctsd cathepsin D multiple interactions
increases expression
ISO Fulvestrant inhibits the reaction [Tea Tree Oil results in increased expression of CTSD mRNA] CTD PMID:31393563 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Cyp4f6 cytochrome P450, family 4, subfamily f, polypeptide 6 multiple interactions ISO Tea Tree Oil inhibits the reaction [Testosterone results in increased expression of CYP4F8 mRNA] CTD PMID:31393563 NCBI chr 7:12,030,276...12,058,020
Ensembl chr 7:12,030,301...12,057,782
JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO Tea Tree Oil results in increased activity of ESR1 protein CTD PMID:31393563 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions
increases expression
ISO Fulvestrant inhibits the reaction [Tea Tree Oil results in increased expression of GREB1 mRNA] CTD PMID:31393563 NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633
JBrowse link
G Pgr progesterone receptor increases expression
multiple interactions
ISO Tea Tree Oil results in increased expression of PGR mRNA
Fulvestrant inhibits the reaction [Tea Tree Oil results in increased expression of PGR mRNA]
CTD PMID:31393563 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G RGD1559459 similar to Expressed sequence AI788959 multiple interactions ISO Tea Tree Oil inhibits the reaction [Testosterone results in increased expression of UGT2B28 mRNA] CTD PMID:31393563 NCBI chr14:21,146,140...21,167,706
Ensembl chr14:21,145,827...21,167,704
JBrowse link
G Sec14l2 SEC14-like lipid binding 2 multiple interactions ISO Tea Tree Oil inhibits the reaction [Testosterone results in increased expression of SEC14L2 mRNA] CTD PMID:31393563 NCBI chr14:78,973,805...78,998,480
Ensembl chr14:78,973,808...78,993,788
JBrowse link
thymol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of ACP5 mRNA]; Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of ACP5 protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA] CTD PMID:30048646 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases activity
ISO [4-cymene co-treated with gamma-terpinene co-treated with Thymol co-treated with carvacrol] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; [4-cymene co-treated with gamma-terpinene co-treated with Thymol co-treated with carvacrol] results in increased activity of AHR protein; [4-cymene co-treated with gamma-terpinene co-treated with Thymol] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; [4-cymene co-treated with gamma-terpinene co-treated with Thymol] results in increased activity of AHR protein; Thymol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
Thymol results in increased activity of AHR protein
CTD PMID:29191726 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization ISO Thymol affects the localization of AIFM1 protein CTD PMID:21640085 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Thymol results in increased expression of BAX protein CTD PMID:21640085 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Thymol results in decreased expression of BCL2 protein CTD PMID:21640085 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP Thymol inhibits the reaction [Isoproterenol results in decreased expression of BCL2L1 mRNA] CTD PMID:26996544 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO Thymol inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA] CTD PMID:30048646 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Casp3 caspase 3 increases activity ISO Thymol results in increased activity of CASP3 protein CTD PMID:21640085 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
ISO
EXP
Thymol results in increased activity of CASP8 protein
Thymol inhibits the reaction [Isoproterenol results in increased expression of CASP8 mRNA]
CTD PMID:21640085 PMID:26996544 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
ISO
EXP
Thymol results in increased activity of CASP9 protein
Thymol inhibits the reaction [Isoproterenol results in increased expression of CASP9 mRNA]
CTD PMID:21640085 PMID:26996544 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions EXP
ISO
Thymol inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]
Thymol inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]
CTD PMID:26680107 PMID:26721194 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ctsk cathepsin K multiple interactions ISO Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of CTSK mRNA]; Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of CTSK protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK protein] CTD PMID:30048646 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO Thymol results in increased expression of CYP1A1 mRNA
Thymol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
CTD PMID:29191726 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Dcstamp dendrocyte expressed seven transmembrane protein multiple interactions ISO Thymol inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA] CTD PMID:30048646 NCBI chr 7:70,807,455...70,822,067
Ensembl chr 7:70,807,581...70,822,078
JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP Thymol inhibits the reaction [Isoproterenol results in increased expression of FAS mRNA] CTD PMID:26996544 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of FOS mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]; Thymol promotes the reaction [Lipopolysaccharides results in decreased expression of FOS protein] CTD PMID:30048646 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gab2 GRB2-associated binding protein 2 multiple interactions ISO Thymol inhibits the reaction [TNFSF11 protein results in increased expression of GAB2 mRNA] CTD PMID:30048646 NCBI chr 1:151,429,844...151,625,708
Ensembl chr 1:151,429,695...151,625,031
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions EXP Thymol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2] CTD PMID:11399263 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions EXP Thymol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2] CTD PMID:11399263 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions EXP Thymol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2] CTD PMID:11399263 NCBI chr10:26,376,805...26,463,680
Ensembl chr10:26,374,694...26,464,346
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO Thymol inhibits the reaction [Dietary Fats results in decreased activity of GSR protein] CTD PMID:26680107 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A increases activity ISO Thymol results in increased activity of HTR3A protein CTD PMID:26456648 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:30048646 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Mitf melanocyte inducing transcription factor multiple interactions ISO Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MITF mRNA] CTD PMID:30048646 NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]; Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 protein] CTD PMID:30048646 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MYC mRNA] CTD PMID:30048646 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of NFATC1 mRNA]; Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of NFATC1 protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein] CTD PMID:30048646 NCBI chr18:74,046,421...74,156,041
Ensembl chr18:74,046,904...74,156,028
JBrowse link
G Ogdh oxoglutarate dehydrogenase multiple interactions EXP Thymol inhibits the reaction [Isoproterenol results in decreased activity of OGDH protein] CTD PMID:26721194 NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO Thymol inhibits the reaction [TNFSF11 protein results in increased expression of SRC mRNA] CTD PMID:30048646 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Thymol inhibits the reaction [Dietary Fats results in increased expression of SREBF1 protein] CTD PMID:26680107 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Thymol inhibits the reaction [Dietary Fats results in increased expression of TGFB1 protein] CTD PMID:26680107 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:30048646 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A multiple interactions ISO Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF11A mRNA]; Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF11A protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A mRNA] CTD PMID:30048646 NCBI chr13:21,928,370...21,986,719
Ensembl chr13:21,928,408...21,986,695
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO Thymol inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of GAB2 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MITF mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MYC mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of SRC mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A mRNA] CTD PMID:30048646 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 increases activity ISO Thymol results in increased activity of TRPV3 protein CTD PMID:16617338 NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Thymol CTD PMID:14557274 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Thymol CTD PMID:14557274 NCBI chr 9:88,696,981...88,808,465 JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Thymol inhibits the reaction [Dietary Fats results in increased expression of VEGFA protein] CTD PMID:26680107 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
thymol sulfate(1-) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of ACP5 mRNA]; Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of ACP5 protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA] CTD PMID:30048646 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases activity
ISO [4-cymene co-treated with gamma-terpinene co-treated with Thymol co-treated with carvacrol] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; [4-cymene co-treated with gamma-terpinene co-treated with Thymol co-treated with carvacrol] results in increased activity of AHR protein; [4-cymene co-treated with gamma-terpinene co-treated with Thymol] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; [4-cymene co-treated with gamma-terpinene co-treated with Thymol] results in increased activity of AHR protein; Thymol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
Thymol results in increased activity of AHR protein
CTD PMID:29191726 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization ISO Thymol affects the localization of AIFM1 protein CTD PMID:21640085 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Thymol results in increased expression of BAX protein CTD PMID:21640085 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Thymol results in decreased expression of BCL2 protein CTD PMID:21640085 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP Thymol inhibits the reaction [Isoproterenol results in decreased expression of BCL2L1 mRNA] CTD PMID:26996544 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO Thymol inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA] CTD PMID:30048646 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Casp3 caspase 3 increases activity ISO Thymol results in increased activity of CASP3 protein CTD PMID:21640085 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
ISO
EXP
Thymol results in increased activity of CASP8 protein
Thymol inhibits the reaction [Isoproterenol results in increased expression of CASP8 mRNA]
CTD PMID:21640085 PMID:26996544 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
EXP
ISO
Thymol inhibits the reaction [Isoproterenol results in increased expression of CASP9 mRNA]
Thymol results in increased activity of CASP9 protein
CTD PMID:21640085 PMID:26996544 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions ISO
EXP
Thymol inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]
Thymol inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]
CTD PMID:26680107 PMID:26721194 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ctsk cathepsin K multiple interactions ISO Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of CTSK mRNA]; Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of CTSK protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK protein] CTD PMID:30048646 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO Thymol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Thymol results in increased expression of CYP1A1 mRNA
CTD PMID:29191726 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Dcstamp dendrocyte expressed seven transmembrane protein multiple interactions ISO Thymol inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA] CTD PMID:30048646 NCBI chr 7:70,807,455...70,822,067
Ensembl chr 7:70,807,581...70,822,078
JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP Thymol inhibits the reaction [Isoproterenol results in increased expression of FAS mRNA] CTD PMID:26996544 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of FOS mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]; Thymol promotes the reaction [Lipopolysaccharides results in decreased expression of FOS protein] CTD PMID:30048646 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gab2 GRB2-associated binding protein 2 multiple interactions ISO Thymol inhibits the reaction [TNFSF11 protein results in increased expression of GAB2 mRNA] CTD PMID:30048646 NCBI chr 1:151,429,844...151,625,708
Ensembl chr 1:151,429,695...151,625,031
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions EXP Thymol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2] CTD PMID:11399263 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions EXP Thymol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2] CTD PMID:11399263 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions EXP Thymol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2] CTD PMID:11399263 NCBI chr10:26,376,805...26,463,680
Ensembl chr10:26,374,694...26,464,346
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO Thymol inhibits the reaction [Dietary Fats results in decreased activity of GSR protein] CTD PMID:26680107 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A increases activity ISO Thymol results in increased activity of HTR3A protein CTD PMID:26456648 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:30048646 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Mitf melanocyte inducing transcription factor multiple interactions ISO Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MITF mRNA] CTD PMID:30048646 NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]; Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 protein] CTD PMID:30048646 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MYC mRNA] CTD PMID:30048646 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of NFATC1 mRNA]; Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of NFATC1 protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein] CTD PMID:30048646 NCBI chr18:74,046,421...74,156,041
Ensembl chr18:74,046,904...74,156,028
JBrowse link
G Ogdh oxoglutarate dehydrogenase multiple interactions EXP Thymol inhibits the reaction [Isoproterenol results in decreased activity of OGDH protein] CTD PMID:26721194 NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO Thymol inhibits the reaction [TNFSF11 protein results in increased expression of SRC mRNA] CTD PMID:30048646 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Thymol inhibits the reaction [Dietary Fats results in increased expression of SREBF1 protein] CTD PMID:26680107 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Thymol inhibits the reaction [Dietary Fats results in increased expression of TGFB1 protein] CTD PMID:26680107 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:30048646 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A multiple interactions ISO Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF11A mRNA]; Thymol inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF11A protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A mRNA] CTD PMID:30048646 NCBI chr13:21,928,370...21,986,719
Ensembl chr13:21,928,408...21,986,695
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO Thymol inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of GAB2 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MITF mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of MYC mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of SRC mRNA]; Thymol inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A mRNA] CTD PMID:30048646 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 increases activity ISO Thymol results in increased activity of TRPV3 protein CTD PMID:16617338 NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Thymol CTD PMID:14557274 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Thymol CTD PMID:14557274 NCBI chr 9:88,696,981...88,808,465 JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Thymol inhibits the reaction [Dietary Fats results in increased expression of VEGFA protein] CTD PMID:26680107 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        biochemical role 19389
          volatile oil component 6578
            p-cymene 61
              4-isopropylbenzyl alcohol 0
              carvacrol 23
              tea tree oil 8
              thymol + 38
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon group molecular entity 19640
                          organic molecular entity 19630
                            organic molecule 19569
                              organic cyclic compound 19360
                                organic aromatic compound 19184
                                  benzenoid aromatic compound 17458
                                    benzenes 17237
                                      toluenes 6253
                                        p-cymene 61
                                          4-isopropylbenzyl alcohol 0
                                          carvacrol 23
                                          tea tree oil 8
                                          thymol + 38
paths to the root