CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: 4,4'-dichlorodiphenylmethane
Accession: CHEBI:28763
browse the term
Definition: A chlorophenylmethane that is methane in which two of the hydrogens have been replaced by p-chlorophenyl groups.
Synonyms: exact_synonym: 1,1'-methylenebis(4-chlorobenzene)
related_synonym: 1-chloro-4-(4-chlorobenzyl)benzene; DDM; Formula=C13H10Cl2; InChI=1S/C13H10Cl2/c14-12-5-1-10(2-6-12)9-11-3-7-13(15)8-4-11/h1-8H,9H2; InChIKey=LQGSWLJZAKVBJH-UHFFFAOYSA-N; SMILES=Clc1ccc(Cc2ccc(Cl)cc2)cc1; bis(4-chlorophenyl)methane; bis(p-chlorophenyl)methane; di(4-chlorophenyl)methane; di(p-chlorophenyl)methane; p,p'-dichlorodiphenylmethane
alt_id: CHEBI:22892; CHEBI:3119
xref: Beilstein:1873121; CAS:101-76-8; Gmelin:1851655; KEGG:C06641; UM-BBD_compID:c0503
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Src
SRC proto-oncogene, non-receptor tyrosine kinase
affects binding
ISO
DDOH binds to SRC protein
CTD
PMID:32278787
NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
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Abca1
ATP binding cassette subfamily A member 1
decreases expression
ISO
DDT results in decreased expression of ABCA1 protein
CTD
PMID:25720399
NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
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Abcb1a
ATP binding cassette subfamily B member 1A
decreases activity increases expression
ISO EXP
DDT metabolite results in decreased activity of ABCB1 protein DDT results in increased expression of ABCB1 mRNA
CTD
PMID:15710169 PMID:23169446 PMID:24464585 PMID:29477483
NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
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Abcc2
ATP binding cassette subfamily C member 2
increases expression
ISO
DDT results in increased expression of ABCC2 mRNA
CTD
PMID:24464585 PMID:31521043
NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
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Abcg2
ATP binding cassette subfamily G member 2
decreases activity
ISO
DDT metabolite results in decreased activity of ABCG2 protein
CTD
PMID:23169446
NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
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Ablim1
actin-binding LIM protein 1
increases methylation
EXP
DDT results in increased methylation of ABLIM1 gene
CTD
PMID:30207508
NCBI chr 1:277,853,877...278,043,096
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Ace
angiotensin I converting enzyme
decreases expression
EXP
DDT results in decreased expression of ACE mRNA
CTD
PMID:30207508
NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
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Ache
acetylcholinesterase
increases expression
ISO
DDT results in increased expression of ACHE mRNA
CTD
PMID:31521043
NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
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Acsbg2
acyl-CoA synthetase bubblegum family member 2
decreases methylation
EXP
DDT results in decreased methylation of ACSBG2 gene
CTD
PMID:30207508
NCBI chr 9:10,172,317...10,203,550
Ensembl chr 9:10,172,832...10,203,460
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Acss2
acyl-CoA synthetase short-chain family member 2
increases expression
EXP
DDT results in increased expression of ACSS2 mRNA
CTD
PMID:29477483
NCBI chr 3:151,032,925...151,075,856
Ensembl chr 3:151,032,952...151,075,856
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Acss3
acyl-CoA synthetase short-chain family member 3
decreases expression
EXP
DDT results in decreased expression of ACSS3 mRNA
CTD
PMID:30207508
NCBI chr 7:49,047,022...49,250,953
Ensembl chr 7:49,047,013...49,250,957
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Acta2
actin alpha 2, smooth muscle
increases expression
EXP
DDT results in increased expression of ACTA2 mRNA
CTD
PMID:30207508
NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
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Actb
actin, beta
decreases expression
ISO
DDT results in decreased expression of ACTB protein
CTD
PMID:26186133
NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
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Actg2
actin gamma 2, smooth muscle
increases expression
EXP
DDT results in increased expression of ACTG2 mRNA
CTD
PMID:30207508
NCBI chr 4:115,215,160...115,239,746
Ensembl chr 4:115,215,060...115,239,723
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Adamts5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
decreases expression
EXP
DDT results in decreased expression of ADAMTS5 mRNA
CTD
PMID:30207508
NCBI chr11:25,411,174...25,456,639
Ensembl chr11:25,410,975...25,456,836
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Adrb2
adrenoceptor beta 2
affects activity
EXP
DDT affects the activity of ADRB2 protein
CTD
PMID:17157474
NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
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Agmo
alkylglycerol monooxygenase
increases methylation
EXP
DDT results in increased methylation of AGMO gene
CTD
PMID:30207508
NCBI chr 6:56,846,859...57,193,918
Ensembl chr 6:56,846,789...57,193,961
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Ahr
aryl hydrocarbon receptor
multiple interactions decreases expression affects binding
ISO
[indole-3-carbinol co-treated with DDT] results in increased expression of AHR mRNA DDT results in decreased expression of AHR mRNA DDT binds to AHR protein
CTD
PMID:17311112 PMID:20436506 PMID:31521043
NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
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Akr1b10
aldo-keto reductase family 1 member B10
increases expression
ISO
DDT results in increased expression of AKR1B10 mRNA
CTD
PMID:26198647
NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
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Alas1
5'-aminolevulinate synthase 1
increases expression
EXP
DDT results in increased expression of ALAS1 mRNA
CTD
PMID:30207508
NCBI chr 8:114,927,704...114,941,038
Ensembl chr 8:114,927,722...114,940,177
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Alb
albumin
decreases expression
ISO
DDT results in decreased expression of ALB mRNA
CTD
PMID:22902829
NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
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Alcam
activated leukocyte cell adhesion molecule
decreases expression
EXP
DDT results in decreased expression of ALCAM mRNA
CTD
PMID:30207508
NCBI chr11:50,780,735...50,985,083
Ensembl chr11:50,781,127...50,985,083
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Alk
ALK receptor tyrosine kinase
multiple interactions
ISO
[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of ALK mRNA
CTD
PMID:28263720
NCBI chr 6:22,696,415...23,203,791
Ensembl chr 6:22,696,397...23,203,775
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Alpl
alkaline phosphatase, biomineralization associated
multiple interactions
ISO
DDT inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]
CTD
PMID:29149346
NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
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Alyref
Aly/REF export factor
increases methylation
EXP
DDT results in increased methylation of ALYREF gene
CTD
PMID:30207508
NCBI chr10:109,768,593...109,774,639
Ensembl chr10:109,770,876...109,774,639
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Anapc11
anaphase promoting complex subunit 11
increases methylation
EXP
DDT results in increased methylation of ANAPC11 gene
CTD
PMID:30207508
NCBI chr10:109,774,779...109,785,877
Ensembl chr10:109,774,878...109,785,877
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Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
increases methylation
EXP
DDT results in increased methylation of ANKS1B gene
CTD
PMID:30207508
NCBI chr 7:30,507,135...31,684,604
Ensembl chr 7:30,699,476...31,681,182
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Anpep
alanyl aminopeptidase, membrane
decreases expression
EXP
DDT results in decreased expression of ANPEP mRNA
CTD
PMID:30207508
NCBI chr 1:141,561,364...141,604,249
Ensembl chr 1:141,561,334...141,604,273
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Antxr1
ANTXR cell adhesion molecule 1
increases methylation
EXP
DDT results in increased methylation of ANTXR1 gene
CTD
PMID:30207508
NCBI chr 4:118,946,267...119,131,202
Ensembl chr 4:118,946,268...119,131,202
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Anxa1
annexin A1
decreases expression
EXP
DDT results in decreased expression of ANXA1 mRNA
CTD
PMID:30207508
NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
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Ap2a2
adaptor related protein complex 2 subunit alpha 2
increases methylation
EXP
DDT results in increased methylation of AP2A2 gene
CTD
PMID:30207508
NCBI chr 1:214,534,217...214,607,497
Ensembl chr 1:214,534,284...214,606,169
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App
amyloid beta precursor protein
increases expression multiple interactions
ISO
DDT results in increased expression of APP protein DDT results in increased expression of and results in increased cleavage of APP protein mutant form; DDT results in increased expression of and results in increased secretion of and results in decreased degradation of APP protein modified form
CTD
PMID:24473795 PMID:25720399
NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
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Ar
androgen receptor
multiple interactions affects binding
ISO EXP
[DDT analog co-treated with Hexachlorocyclohexane analog co-treated with Chlorobenzenes co-treated with Mirex co-treated with Polychlorinated Biphenyls co-treated with Chlordan co-treated with Toxaphene co-treated with Hydrocarbons, Chlorinated] inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; DDT binds to and results in decreased activity of AR protein; DDT inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; DDT inhibits the reaction [Dihydrotestosterone binds to AR protein]; DDT inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; DDT inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; DDT inhibits the reaction [Metribolone affects the localization of AR protein]; DDT inhibits the reaction [Metribolone promotes the reaction [AR protein binds to KLK3 promoter]]; DDT inhibits the reaction [Metribolone results in increased expression of AR protein]; Dihydrotestosterone inhibits the reaction [DDT results in increased activity of AR protein] DDT binds to AR protein
CTD
PMID:9705896 PMID:14565775 PMID:14579009 PMID:15064155 PMID:15483189 PMID:21295777 PMID:25682698 PMID:26022396
NCBI chr X:67,656,253...67,828,998
Ensembl chr X:67,656,253...67,829,026
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Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
decreases expression
EXP
DDT results in decreased expression of ARAP2 mRNA
CTD
PMID:30207508
NCBI chr14:48,726,033...48,922,809
Ensembl chr14:48,726,045...48,922,983
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Arf1
ADP-ribosylation factor 1
decreases expression
EXP
DDT results in decreased expression of ARF1 mRNA
CTD
PMID:19797855
NCBI chr10:45,562,700...45,579,214
Ensembl chr10:45,563,547...45,579,029
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Arfgef1
ADP ribosylation factor guanine nucleotide exchange factor 1
decreases expression
EXP
DDT results in decreased expression of ARFGEF1 mRNA
CTD
PMID:30207508
NCBI chr 5:8,666,046...8,760,458
Ensembl chr 5:8,666,200...8,760,458
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Arhgap10
Rho GTPase activating protein 10
increases methylation
EXP
DDT results in increased methylation of ARHGAP10 gene
CTD
PMID:30207508
NCBI chr19:34,138,978...34,406,593
Ensembl chr19:34,139,997...34,402,436
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Arhgap15
Rho GTPase activating protein 15
decreases methylation
EXP
DDT results in decreased methylation of ARHGAP15 gene
CTD
PMID:30207508
NCBI chr 3:28,626,987...29,236,225
Ensembl chr 3:28,627,084...29,236,219
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Arhgap5
Rho GTPase activating protein 5
decreases expression
EXP
DDT results in decreased expression of ARHGAP5 mRNA
CTD
PMID:30207508
NCBI chr 6:73,345,129...73,408,304
Ensembl chr 6:73,345,392...73,405,880
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Arhgap6
Rho GTPase activating protein 6
decreases expression
EXP
DDT results in decreased expression of ARHGAP6 mRNA
CTD
PMID:30207508
NCBI chr X:26,314,561...26,845,242
Ensembl chr X:26,315,878...26,376,467
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Arhgef33
Rho guanine nucleotide exchange factor 33
increases methylation
EXP
DDT results in increased methylation of ARHGEF33 gene
CTD
PMID:30207508
NCBI chr 6:2,982,324...3,100,358
Ensembl chr 6:3,012,804...3,095,500
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Arl2
ADP-ribosylation factor like GTPase 2
decreases expression
EXP
DDT results in decreased expression of ARL2 mRNA
CTD
PMID:30207508
NCBI chr 1:221,504,150...221,516,191
Ensembl chr 1:221,504,170...221,516,110
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Arsb
arylsulfatase B
decreases methylation
EXP
DDT results in decreased methylation of ARSB gene
CTD
PMID:30207508
NCBI chr 2:23,385,154...23,543,028
Ensembl chr 2:23,385,183...23,544,963
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Atf3
activating transcription factor 3
increases expression
EXP
DDT results in increased expression of ATF3 mRNA
CTD
PMID:30207508
NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
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Atp1a1
ATPase Na+/K+ transporting subunit alpha 1
multiple interactions
ISO
[o,p'-DDT co-treated with DDT] results in increased expression of ATP1A1 mRNA
CTD
PMID:27325568
NCBI chr 2:204,003,742...204,032,023
Ensembl chr 2:204,003,742...204,032,023
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Atrnl1
attractin like 1
increases methylation
EXP
DDT results in increased methylation of ATRNL1 gene
CTD
PMID:30207508
NCBI chr 1:278,546,113...279,098,977
Ensembl chr 1:278,557,792...278,815,473
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Bace1
beta-secretase 1
increases expression
ISO
DDT results in increased expression of BACE1
CTD
PMID:25720399
NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361
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Bcap29
B-cell receptor-associated protein 29
decreases expression
EXP
DDT results in decreased expression of BCAP29 mRNA
CTD
PMID:30207508
NCBI chr 6:50,883,758...50,923,743
Ensembl chr 6:50,883,787...50,923,510
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Bcat1
branched chain amino acid transaminase 1
decreases expression
EXP
DDT results in decreased expression of BCAT1 mRNA
CTD
PMID:30207508
NCBI chr 4:179,259,305...179,340,021
Ensembl chr 4:179,259,308...179,339,795
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Bche
butyrylcholinesterase
decreases expression
EXP
DDT results in decreased expression of BCHE mRNA
CTD
PMID:30207508
NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
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Bcl2
BCL2, apoptosis regulator
multiple interactions decreases expression
ISO
[DDT results in increased activity of ESR1 protein] which results in increased expression of BCL2 mRNA DDT results in decreased expression of BCL2 protein
CTD
PMID:22403704 PMID:28263910
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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Bdnf
brain-derived neurotrophic factor
multiple interactions
ISO
[Permethrin co-treated with DDT co-treated with Diethylstilbestrol] inhibits the reaction [Potassium results in increased expression of BDNF mRNA]; DDT inhibits the reaction [Potassium results in increased expression of BDNF mRNA]
CTD
PMID:15527870
NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
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Bgn
biglycan
increases expression
EXP
DDT results in increased expression of BGN mRNA
CTD
PMID:30207508
NCBI chr X:157,319,042...157,331,204
Ensembl chr X:157,319,046...157,331,204
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Bhlha15
basic helix-loop-helix family, member a15
multiple interactions
ISO
[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of BHLHA15 mRNA
CTD
PMID:28263720
NCBI chr12:12,403,385...12,409,103
Ensembl chr12:12,403,385...12,407,561
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Birc6
baculoviral IAP repeat-containing 6
increases methylation
EXP
DDT results in increased methylation of BIRC6 gene
CTD
PMID:30207508
NCBI chr 6:21,900,763...22,092,484
Ensembl chr 6:21,950,100...22,092,346
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Bmf
Bcl2 modifying factor
decreases expression
EXP
DDT results in decreased expression of BMF mRNA
CTD
PMID:30207508
NCBI chr 3:110,303,515...110,324,125
Ensembl chr 3:110,306,067...110,324,084
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Bod1l1
biorientation of chromosomes in cell division 1-like 1
decreases expression
EXP
DDT results in decreased expression of BOD1L1 mRNA
CTD
PMID:30207508
NCBI chr14:73,738,137...73,792,935
Ensembl chr14:73,738,137...73,791,656
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Btg2
BTG anti-proliferation factor 2
increases expression
EXP
DDT results in increased expression of BTG2 mRNA
CTD
PMID:30207508
NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982
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Cacna2d3
calcium voltage-gated channel auxiliary subunit alpha2delta 3
decreases methylation
EXP
DDT results in decreased methylation of CACNA2D3 gene
CTD
PMID:30207508
NCBI chr16:4,871,348...5,795,825
Ensembl chr16:4,871,650...5,795,825
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Cadps
calcium dependent secretion activator
decreases expression
EXP
DDT results in decreased expression of CADPS mRNA
CTD
PMID:30207508
NCBI chr15:15,275,489...15,690,575
Ensembl chr15:15,275,541...15,667,778
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Calb2
calbindin 2
increases expression
EXP
DDT results in increased expression of CALB2 mRNA
CTD
PMID:30207508
NCBI chr19:41,482,743...41,509,617
Ensembl chr19:41,482,728...41,509,658
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Cald1
caldesmon 1
decreases expression
EXP
DDT results in decreased expression of CALD1 mRNA
CTD
PMID:30207508
NCBI chr 4:62,103,948...62,291,375
Ensembl chr 4:62,220,736...62,291,489
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Calhm2
calcium homeostasis modulator family member 2
decreases expression
EXP
DDT results in decreased expression of CALHM2 mRNA
CTD
PMID:30207508
NCBI chr 1:266,908,367...266,914,093
Ensembl chr 1:266,908,369...266,914,093
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Camk2d
calcium/calmodulin-dependent protein kinase II delta
increases methylation
EXP
DDT results in increased methylation of CAMK2D gene
CTD
PMID:30207508
NCBI chr 2:230,900,907...231,132,207
Ensembl chr 2:230,901,126...231,132,039
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Canx
calnexin
decreases expression
EXP
DDT results in decreased expression of CANX mRNA
CTD
PMID:30207508
NCBI chr10:35,800,942...35,833,939
Ensembl chr10:35,800,942...35,833,861
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Capn2
calpain 2
increases methylation
EXP
DDT results in increased methylation of CAPN2 gene
CTD
PMID:30207508
NCBI chr13:100,878,649...100,928,811
Ensembl chr13:100,878,650...100,928,811
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Carmn
cardiac mesoderm enhancer-associated non-coding RNA
increases expression
ISO
DDT results in increased expression of CARMN mRNA
CTD
PMID:25014179
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Casp3
caspase 3
increases activity multiple interactions decreases activity
ISO EXP
DDT results in increased activity of CASP3 protein SB 203580 inhibits the reaction [DDT results in increased activity of CASP3 protein] DDT inhibits the reaction [TGFB1 protein results in increased activity of CASP3 protein] DDT results in decreased activity of CASP3 protein
CTD
PMID:10200566 PMID:15603917
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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Casp7
caspase 7
increases activity multiple interactions
ISO
DDT results in increased activity of CASP7 protein SB 203580 inhibits the reaction [DDT results in increased activity of CASP7 protein]
CTD
PMID:15603917
NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
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Cat
catalase
multiple interactions
EXP
[Polychlorinated Biphenyls co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Chlordan co-treated with nonachlor] inhibits the reaction [Fish Oils results in increased expression of CAT mRNA]
CTD
PMID:28659405
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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Cbln1
cerebellin 1 precursor
decreases expression
EXP
DDT results in decreased expression of CBLN1 mRNA
CTD
PMID:30207508
NCBI chr19:20,607,507...20,611,316
Ensembl chr19:20,607,507...20,611,316
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Ccn3
cellular communication network factor 3
decreases expression
EXP
DDT results in decreased expression of NOV mRNA
CTD
PMID:30207508
NCBI chr 7:94,375,134...94,382,154
Ensembl chr 7:94,375,020...94,383,024
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Ccnd1
cyclin D1
multiple interactions increases expression
ISO
DDT promotes the reaction [ESR1 protein binds to CCND1 promoter]; DDT promotes the reaction [FOS protein binds to CCND1 promoter] Acetylcysteine inhibits the reaction [DDT results in increased phosphorylation of CCND1 protein] DDT results in increased expression of CCND1 protein DDT results in increased expression of CCND1 mRNA; DDT results in increased expression of CCND1 protein
CTD
PMID:8927716 PMID:9049186 PMID:23684557 PMID:24968063
NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
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Ccnd2
cyclin D2
decreases expression
ISO
DDT results in decreased expression of CCND2 mRNA
CTD
PMID:25014179
NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
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Cd244
CD244 molecule
increases methylation
EXP
DDT results in increased methylation of CD244 gene
CTD
PMID:30207508
NCBI chr13:89,959,091...89,995,993
Ensembl chr13:89,975,267...89,995,974
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Cd2ap
CD2-associated protein
decreases expression
EXP
DDT results in decreased expression of CD2AP mRNA
CTD
PMID:30207508
NCBI chr 9:20,794,680...20,858,438
Ensembl chr 9:20,765,296...20,858,504
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Cd34
CD34 molecule
increases expression
EXP
DDT results in increased expression of CD34 mRNA
CTD
PMID:30207508
NCBI chr13:113,691,842...113,711,259
Ensembl chr13:113,691,932...113,711,647
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Cd86
CD86 molecule
multiple interactions
ISO
DDT inhibits the reaction [endotoxin, Escherichia coli results in increased expression of CD86 protein]
CTD
PMID:28412309
NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
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Cdh1
cadherin 1
multiple interactions decreases expression
ISO
Acetylcysteine inhibits the reaction [DDT results in decreased expression of CDH1 mRNA]; DDT inhibits the reaction [CDH1 protein binds to CTNNB1 protein]; INCB018424 inhibits the reaction [DDT results in decreased expression of CDH1 mRNA]; WP1066 inhibits the reaction [DDT results in decreased expression of CDH1 mRNA] DDT results in decreased expression of CDH1 mRNA; DDT results in decreased expression of CDH1 protein
CTD
PMID:22902829 PMID:24820114
NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
G
Cdh2
cadherin 2
multiple interactions increases expression
ISO
Acetylcysteine inhibits the reaction [DDT results in increased expression of CDH2 mRNA]; INCB018424 inhibits the reaction [DDT results in increased expression of CDH2 mRNA]; WP1066 inhibits the reaction [DDT results in increased expression of CDH2 mRNA]
CTD
PMID:24820114
NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
G
Cdk2
cyclin dependent kinase 2
increases activity multiple interactions
ISO
DDT results in increased activity of CDK2 protein DDT results in increased phosphorylation of and results in increased activity of CDK2 protein; fulvestrant inhibits the reaction [DDT results in increased phosphorylation of and results in increased activity of CDK2 protein]
CTD
PMID:8927716 PMID:9049186 PMID:9168006
NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
G
Cdk4
cyclin-dependent kinase 4
increases expression
ISO
DDT results in increased expression of CDK4 protein
CTD
PMID:23684557
NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
multiple interactions decreases expression
ISO
DDT inhibits the reaction [TRP53 protein binds to CDKN1A promoter]; DDT promotes the reaction [ESR1 protein binds to CDKN1A promoter] DDT results in decreased expression of CDKN1A mRNA
CTD
PMID:23684557
NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
G
Cdkn2a
cyclin-dependent kinase inhibitor 2A
decreases expression increases methylation
EXP
DDT results in decreased expression of CDKN2A mRNA alternative form; DDT results in decreased expression of CDKN2A protein alternative form DDT results in increased methylation of CDKN2A promoter alternative form
CTD
PMID:25410620
NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
G
Cebpa
CCAAT/enhancer binding protein alpha
multiple interactions
ISO
DDT results in increased activity of and results in increased localization of CEBPA protein
CTD
PMID:11911853
NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
G
Cemip
cell migration inducing hyaluronidase
decreases expression
EXP
DDT results in decreased expression of CEMIP mRNA
CTD
PMID:30207508
NCBI chr 1:146,069,774...146,226,320
Ensembl chr 1:146,069,771...146,226,462
G
Cep170b
centrosomal protein 170B
increases methylation
EXP
DDT results in increased methylation of CEP170B gene
CTD
PMID:30207508
NCBI chr 6:137,283,814...137,311,512
Ensembl chr 6:137,288,810...137,311,932
G
Ces1d
carboxylesterase 1D
increases methylation
EXP
DDT results in increased methylation of CES1D gene
CTD
PMID:30207508
NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
G
Ces3a
carboxylesterase 3a
increases expression
EXP
DDT results in increased expression of CES3 mRNA
CTD
PMID:29477483
NCBI chr19:37,070,705...37,079,411
G
Cftr
CF transmembrane conductance regulator
multiple interactions
ISO
DDT inhibits the reaction [S-Nitrosoglutathione results in increased expression of and results in increased stability of CFTR protein]
CTD
PMID:14766015
NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
G
Cga
glycoprotein hormones, alpha polypeptide
multiple interactions increases expression
ISO
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [DDT results in increased expression of CGA mRNA] DDT promotes the reaction [[CGA protein results in increased activity of FSHR protein] which results in increased abundance of Cyclic AMP]
CTD
PMID:24814263 PMID:26895433
NCBI chr 5:50,362,491...50,393,368
Ensembl chr 5:50,381,244...50,393,367
G
Chrm4
cholinergic receptor, muscarinic 4
multiple interactions
ISO
[DDT co-treated with bioallethrin] results in increased expression of CHRM4 mRNA
CTD
PMID:10192214
NCBI chr 3:80,833,272...80,841,165
Ensembl chr 3:80,833,272...80,841,006
G
Clasp2
cytoplasmic linker associated protein 2
decreases methylation
EXP
DDT results in decreased methylation of CLASP2 gene
CTD
PMID:30207508
NCBI chr 8:122,003,719...122,185,495
Ensembl chr 8:122,003,916...122,185,495
G
Clip4
CAP-GLY domain containing linker protein family, member 4
increases methylation
EXP
DDT results in increased methylation of CLIP4 gene
CTD
PMID:30207508
NCBI chr 6:23,222,020...23,316,962
Ensembl chr 6:23,222,021...23,316,962
G
Clstn2
calsyntenin 2
decreases expression
EXP
DDT results in decreased expression of CLSTN2 mRNA
CTD
PMID:30207508
NCBI chr 8:105,322,577...106,036,821
Ensembl chr 8:105,323,837...105,462,168
G
Clu
clusterin
decreases expression
EXP
DDT results in decreased expression of CLU mRNA
CTD
PMID:30207508
NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
G
Cmc1
C-x(9)-C motif containing 1
increases methylation
EXP
DDT results in increased methylation of CMC1 gene
CTD
PMID:30207508
NCBI chr 8:126,437,345...126,495,347
Ensembl chr 8:126,437,345...126,495,347
G
Col11a1
collagen type XI alpha 1 chain
decreases expression
EXP
DDT results in decreased expression of COL11A1 mRNA
CTD
PMID:30207508
NCBI chr 2:216,863,423...217,056,523
Ensembl chr 2:216,863,428...217,056,523
G
Col1a1
collagen type I alpha 1 chain
increases expression
ISO EXP
DDT results in increased expression of COL1A1 mRNA
CTD
PMID:22902829 PMID:30207508
NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
G
Col3a1
collagen type III alpha 1 chain
increases expression
EXP
DDT results in increased expression of COL3A1 mRNA
CTD
PMID:30207508
NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
G
Col4a1
collagen type IV alpha 1 chain
increases expression
EXP
DDT results in increased expression of COL4A1 mRNA
CTD
PMID:30207508
NCBI chr16:83,522,162...83,632,153
Ensembl chr16:83,522,162...83,632,153
G
Col4a5
collagen type IV alpha 5 chain
decreases expression
EXP
DDT results in decreased expression of COL4A5 mRNA
CTD
PMID:30207508
NCBI chr X:112,769,595...112,983,720
Ensembl chr X:112,769,645...112,983,685
G
Col6a1
collagen type VI alpha 1 chain
increases expression
EXP
DDT results in increased expression of COL6A1 mRNA
CTD
PMID:30207508
NCBI chr20:12,657,913...12,676,370
Ensembl chr20:12,658,065...12,675,561
G
Col6a2
collagen type VI alpha 2 chain
increases expression
EXP
DDT results in increased expression of COL6A2 mRNA
CTD
PMID:30207508
NCBI chr20:12,773,472...12,801,179
Ensembl chr20:12,773,427...12,801,180
G
Coq2
coenzyme Q2, polyprenyltransferase
increases methylation
EXP
DDT results in increased methylation of COQ2 gene
CTD
PMID:30207508
NCBI chr14:10,581,102...10,601,093
Ensembl chr14:10,581,136...10,600,566
G
Coro6
coronin 6
increases expression
ISO
DDT results in increased expression of CORO6 mRNA
CTD
PMID:25014179
NCBI chr10:62,691,952...62,700,658
Ensembl chr10:62,691,953...62,699,723
G
Cpe
carboxypeptidase E
decreases expression
EXP
DDT results in decreased expression of CPE mRNA
CTD
PMID:30207508
NCBI chr16:26,906,716...27,014,811
Ensembl chr16:26,906,716...27,014,813
G
Creb1
cAMP responsive element binding protein 1
increases activity
ISO
DDT results in increased activity of CREB1 protein
CTD
PMID:18791200
NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
G
Creb3l1
cAMP responsive element binding protein 3-like 1
increases expression
EXP
DDT results in increased expression of CREB3L1 mRNA
CTD
PMID:30207508
NCBI chr 3:80,892,433...80,933,283
Ensembl chr 3:80,892,435...80,933,283
G
Crebbp
CREB binding protein
increases activity
ISO
DDT results in increased activity of CREBBP protein
CTD
PMID:22609851
NCBI chr10:11,590,994...11,721,039
Ensembl chr10:11,595,044...11,721,039
G
Crim1
cysteine rich transmembrane BMP regulator 1
decreases expression
EXP
DDT results in decreased expression of CRIM1 mRNA
CTD
PMID:30207508
NCBI chr 6:788,490...962,663
Ensembl chr 6:788,548...960,703
G
Csrnp3
cysteine and serine rich nuclear protein 3
increases methylation
EXP
DDT results in increased methylation of CSRNP3 gene
CTD
PMID:30207508
NCBI chr 3:51,883,559...52,120,290
Ensembl chr 3:51,883,559...52,120,290
G
Ctnna2
catenin alpha 2
decreases expression
EXP
DDT results in decreased expression of CTNNA2 mRNA
CTD
PMID:30207508
NCBI chr 4:107,880,611...109,042,724
Ensembl chr 4:107,881,826...108,008,484
G
Ctnna3
catenin alpha 3
decreases expression
EXP
DDT results in decreased expression of CTNNA3 mRNA
CTD
PMID:30207508
NCBI chr20:25,063,124...26,640,428
Ensembl chr20:26,516,836...26,589,209
G
Ctnnb1
catenin beta 1
multiple interactions affects localization increases expression
ISO
Acetylcysteine inhibits the reaction [DDT results in increased expression of and results in decreased phosphorylation of CTNNB1 protein]; DDT inhibits the reaction [CDH1 protein binds to CTNNB1 protein]; DDT results in increased expression of and results in decreased phosphorylation of CTNNB1 protein DDT affects the localization of CTNNB1 protein DDT results in increased expression of CTNNB1 protein
CTD
PMID:22902829 PMID:24968063
NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
G
Ctsd
cathepsin D
multiple interactions
ISO
[DDT results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA
CTD
PMID:22403704
NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
G
Cxcl12
C-X-C motif chemokine ligand 12
increases expression
ISO
DDT results in increased expression of CXCL12 mRNA
CTD
PMID:25014179
NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
G
Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
increases expression
ISO
DDT results in increased expression of CYP11A1 mRNA
CTD
PMID:12858341
NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
G
Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
increases expression multiple interactions
ISO
DDT results in increased expression of CYP17A1 mRNA fulvestrant inhibits the reaction [DDT results in increased expression of CYP17A1 mRNA]
CTD
PMID:23684557
NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
G
Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
decreases expression increases expression increases activity
EXP ISO
DDT results in decreased expression of CYP19A1 mRNA DDT results in increased expression of CYP19A1 mRNA DDT results in increased activity of CYP19A1 protein
CTD
PMID:12035542 PMID:28263910 PMID:30817981
NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions decreases expression increases expression
ISO EXP
[indole-3-carbinol co-treated with DDT] results in increased expression of CYP1A1 mRNA; aurapten inhibits the reaction [DDT results in increased expression of CYP1A1 mRNA]; nobiletin inhibits the reaction [DDT results in increased expression of CYP1A1 mRNA] DDT results in decreased expression of CYP1A1 mRNA [Polychlorinated Biphenyls co-treated with DDT co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CYP1A1 mRNA
CTD
PMID:16036770 PMID:17311112 PMID:20865247 PMID:28263910 PMID:29477483 PMID:31521043
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases expression
EXP
DDT results in increased expression of CYP1A2 mRNA
CTD
PMID:29477483
NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
G
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
multiple interactions
ISO
[indole-3-carbinol co-treated with DDT] results in increased expression of CYP1B1 mRNA
CTD
PMID:17311112
NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
G
Cyp2a1
cytochrome P450, family 2, subfamily a, polypeptide 1
increases expression
EXP
DDT results in increased expression of CYP2A1 mRNA
CTD
PMID:29477483
NCBI chr 1:83,711,223...83,725,222
Ensembl chr 1:83,653,234...83,766,484
G
Cyp2a2
cytochrome P450, family 2, subfamily a, polypeptide 2
increases expression
EXP
DDT results in increased expression of CYP2A2 mRNA
CTD
PMID:29477483
NCBI chr 1:83,744,229...83,766,490
Ensembl chr 1:83,653,234...83,766,484
G
Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
multiple interactions increases expression increases activity
EXP ISO
[DDT co-treated with Diethylnitrosamine] results in decreased expression of CYP2B1 mRNA; [DDT co-treated with Diethylnitrosamine] results in increased expression of CYP2B1 mRNA DDT results in increased expression of CYP2B10 mRNA [Androstanols co-treated with fulvestrant] inhibits the reaction [DDT results in increased expression of CYP2B10 mRNA]; Androstanols inhibits the reaction [DDT results in increased expression of CYP2B10 mRNA]; DDT promotes the reaction [GADD45B protein binds to CYP2B10 promoter]; DDT promotes the reaction [NR1I3 protein binds to CYP2B10 promoter]; DDT promotes the reaction [PPARGC1A protein binds to CYP2B10 promoter] DDT results in increased activity of CYP2B1 protein DDT results in increased expression of CYP2B1 protein
CTD
PMID:1372805 PMID:7595932 PMID:11948501 PMID:12597452 PMID:15729006 PMID:15885732 PMID:23684557
NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
G
Cyp2b2
cytochrome P450, family 2, subfamily b, polypeptide 2
multiple interactions increases expression
EXP
[DDT co-treated with Diethylnitrosamine] results in decreased expression of CYP2B2 mRNA; [DDT co-treated with Diethylnitrosamine] results in increased expression of CYP2B2 mRNA DDT results in increased expression of CYP2B2 protein
CTD
PMID:7595932 PMID:15885732
NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
G
Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
increases expression decreases expression multiple interactions
ISO EXP
DDT results in increased expression of CYP2B6 mRNA; DDT results in increased expression of CYP2B6 protein DDT results in decreased expression of CYP2B3 mRNA [CYP2B6 gene SNP affects the susceptibility to DDT] which affects the abundance of Dichlorodiphenyl Dichloroethylene; CYP2B6 gene SNP affects the reaction [DDT results in increased abundance of Dichlorodiphenyl Dichloroethylene]
CTD
PMID:15548381 PMID:20686338 PMID:27839851 PMID:29477483
NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
G
Cyp2d1
cytochrome P450, family 2, subfamily d, polypeptide 1
decreases expression
EXP
DDT results in decreased expression of CYP2D1 mRNA
CTD
PMID:29477483
NCBI chr 7:123,625,641...123,630,045
Ensembl chr 7:123,625,590...123,638,765
G
Cyp2t1
cytochrome P450, family 2, subfamily t, polypeptide 1
increases methylation
EXP
DDT results in increased methylation of CYP2T1 gene
CTD
PMID:30207508
NCBI chr 1:83,965,370...83,969,466
Ensembl chr 1:83,965,608...83,969,559
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions
EXP
[DDT co-treated with Diethylnitrosamine] results in decreased expression of CYP3A2 mRNA; [DDT co-treated with Diethylnitrosamine] results in increased expression of CYP3A2 mRNA
CTD
PMID:15885732
NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
G
Cyp3a62
cytochrome P450, family 3, subfamily a, polypeptide 62
increases expression decreases expression multiple interactions
ISO EXP
DDT results in increased expression of CYP3A4 mRNA; DDT results in increased expression of CYP3A4 protein DDT results in decreased expression of CYP3A11 protein DDT results in increased expression of CYP3A11 protein [DDT co-treated with Dieldrin] results in increased expression of CYP3A4 mRNA
CTD
PMID:11948501 PMID:12597452 PMID:15548381 PMID:17035600 PMID:20686338 PMID:25028461
NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
G
Cyria
CYFIP related Rac1 interactor A
decreases expression
EXP
DDT results in decreased expression of CYRIA mRNA
CTD
PMID:30207508
NCBI chr 6:37,555,167...37,661,196
Ensembl chr 6:37,555,182...37,665,064
G
Dach1
dachshund family transcription factor 1
decreases expression
EXP
DDT results in decreased expression of DACH1 mRNA
CTD
PMID:30207508
NCBI chr15:82,095,003...82,482,272
Ensembl chr15:82,099,159...82,482,009
G
Dclre1c
DNA cross-link repair 1C
increases methylation
EXP
DDT results in increased methylation of DCLRE1C gene
CTD
PMID:30207508
NCBI chr17:78,782,512...78,812,140
Ensembl chr17:78,783,437...78,812,111
G
Def6
DEF6 guanine nucleotide exchange factor
increases methylation
EXP
DDT results in increased methylation of DEF6 gene
CTD
PMID:30207508
NCBI chr20:7,788,120...7,809,011
Ensembl chr20:7,788,084...7,809,560
G
Des
desmin
increases expression
EXP
DDT results in increased expression of DES mRNA
CTD
PMID:30207508
NCBI chr 9:82,556,574...82,564,288
Ensembl chr 9:82,556,573...82,564,294
G
Dlx5
distal-less homeobox 5
increases expression
ISO
DDT results in increased expression of DLX5 mRNA
CTD
PMID:25014179
NCBI chr 4:32,387,741...32,392,085
Ensembl chr 4:32,387,741...32,392,007
G
Dmd
dystrophin
increases methylation
EXP
DDT results in increased methylation of DMD gene
CTD
PMID:30207508
NCBI chr X:51,149,358...53,519,271
Ensembl chr X:51,286,737...53,519,259
G
Dnajc15
DnaJ heat shock protein family (Hsp40) member C15
increases expression
ISO
DDT results in increased expression of DNAJC15 mRNA
CTD
PMID:25014179
NCBI chr15:59,990,131...60,056,710
Ensembl chr15:59,990,131...60,056,710
G
Dnmt1
DNA methyltransferase 1
decreases expression increases expression
EXP
DDT results in decreased expression of DNMT1 mRNA DDT results in increased expression of DNMT1 mRNA; DDT results in increased expression of DNMT1 protein
CTD
PMID:19797855 PMID:25410620
NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
G
Dnmt3a
DNA methyltransferase 3 alpha
decreases expression
EXP
DDT results in decreased expression of DNMT3A mRNA
CTD
PMID:19797855
NCBI chr 6:28,205,375...28,346,052
Ensembl chr 6:28,235,695...28,340,577
G
Dnmt3b
DNA methyltransferase 3 beta
decreases expression
EXP
DDT results in decreased expression of DNMT3B mRNA
CTD
PMID:19797855
NCBI chr 3:149,131,541...149,170,061
Ensembl chr 3:149,131,785...149,208,786
G
Dok5
docking protein 5
increases methylation
EXP
DDT results in increased methylation of DOK5 gene
CTD
PMID:30207508
NCBI chr 3:168,345,116...168,482,445
Ensembl chr 3:168,345,152...168,482,441
G
Dpy19l2
dpy-19 like 2
decreases methylation
EXP
DDT results in decreased methylation of DPY19L2 gene
CTD
PMID:30207508
NCBI chr 8:25,710,492...25,829,589
Ensembl chr 8:25,710,472...25,829,569
G
Dst
dystonin
increases methylation
EXP
DDT results in increased methylation of DST gene
CTD
PMID:30207508
NCBI chr 9:37,902,336...38,296,961
Ensembl chr 9:37,902,303...38,196,273
G
Dym
dymeclin
increases methylation
EXP
DDT results in increased methylation of DYM gene
CTD
PMID:30207508
NCBI chr18:70,996,074...71,313,033
Ensembl chr18:70,996,044...71,313,084
G
E2f1
E2F transcription factor 1
increases expression multiple interactions
ISO
DDT results in increased expression of E2F1 mRNA; DDT results in increased expression of E2F1 protein fulvestrant inhibits the reaction [DDT results in increased expression of E2F1 mRNA]
CTD
PMID:23684557
NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
G
Ebna1bp2
EBNA1 binding protein 2
increases expression
EXP
DDT results in increased expression of EBNA1BP2 mRNA
CTD
PMID:30207508
NCBI chr 5:137,458,692...137,463,255
Ensembl chr 5:137,670,123...137,674,802
G
Egf
epidermal growth factor
multiple interactions
EXP
[EGF protein co-treated with DDT] results in increased expression of MYC mRNA
CTD
PMID:12632255
NCBI chr 2:68,820,616...68,895,537
G
Egflam
EGF-like, fibronectin type III and laminin G domains
increases expression
EXP
DDT results in increased expression of EGFLAM mRNA
CTD
PMID:30207508
NCBI chr 2:56,503,002...56,681,334
Ensembl chr 2:56,502,807...56,679,955
G
Egln2
egl-9 family hypoxia-inducible factor 2
increases methylation
EXP
DDT results in increased methylation of EGLN2 gene
CTD
PMID:30207508
NCBI chr 1:83,969,456...83,977,665
Ensembl chr 1:83,969,457...83,977,236
G
Egr1
early growth response 1
decreases expression increases expression
ISO EXP
DDT results in decreased expression of EGR1 mRNA DDT results in increased expression of EGR1 mRNA
CTD
PMID:25014179 PMID:30207508
NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
G
Egr2
early growth response 2
increases expression
EXP
DDT results in increased expression of EGR2 mRNA
CTD
PMID:30207508
NCBI chr20:22,452,170...22,461,018
Ensembl chr20:22,454,463...22,459,025
G
Eif4a2
eukaryotic translation initiation factor 4A2
increases expression
ISO
DDT results in increased expression of EIF4A2 mRNA
CTD
PMID:25014179
NCBI chr11:81,373,047...81,379,680
Ensembl chr11:81,373,048...81,379,871
G
Elk1
ETS transcription factor ELK1
increases activity
ISO
DDT results in increased activity of ELK1 protein
CTD
PMID:18791200
NCBI chr X:1,287,875...1,304,822
Ensembl chr X:1,297,099...1,304,822
G
Emilin2
elastin microfibril interfacer 2
increases expression
EXP
DDT results in increased expression of EMILIN2 mRNA
CTD
PMID:30207508
NCBI chr 9:119,594,049...119,653,675
Ensembl chr 9:119,594,629...119,653,255
G
Enc1
ectodermal-neural cortex 1
decreases expression increases expression
EXP
DDT results in decreased expression of ENC1 mRNA DDT results in increased expression of ENC1 mRNA
CTD
PMID:19797855 PMID:30207508
NCBI chr 2:28,049,217...28,061,023
Ensembl chr 2:28,049,217...28,061,029
G
Eno1
enolase 1
decreases expression
ISO
DDT results in decreased expression of ENO1 protein
CTD
PMID:26186133
NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609
G
Enpp3
ectonucleotide pyrophosphatase/phosphodiesterase 3
decreases methylation
EXP
DDT results in decreased methylation of ENPP3 gene
CTD
PMID:30207508
NCBI chr 1:21,613,148...21,684,483
Ensembl chr 1:21,613,148...21,684,480
G
Epas1
endothelial PAS domain protein 1
decreases expression
EXP
DDT results in decreased expression of EPAS1 mRNA
CTD
PMID:30207508
NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265
G
Epha3
Eph receptor A3
multiple interactions
ISO
[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of EPHA3 mRNA
CTD
PMID:28263720
NCBI chr11:421,253...783,037
Ensembl chr11:421,135...782,954
G
Epha8
Eph receptor A8
multiple interactions
ISO
[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of EPHA8 mRNA
CTD
PMID:28263720
NCBI chr 5:155,293,731...155,321,016
Ensembl chr 5:155,295,314...155,316,495
G
Ephx1
epoxide hydrolase 1
increases activity
EXP
DDT results in increased activity of EPHX1 protein
CTD
PMID:1372805
NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
G
Erbb2
erb-b2 receptor tyrosine kinase 2
increases phosphorylation
ISO
DDT results in increased phosphorylation of ERBB2 protein
CTD
PMID:9070211
NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
G
Esd
esterase D
increases expression
EXP
DDT results in increased expression of ESD mRNA
CTD
PMID:29477483
NCBI chr15:56,756,848...56,776,348
Ensembl chr15:56,756,661...56,776,348
G
Esr1
estrogen receptor 1
multiple interactions increases expression decreases expression increases methylation increases activity affects binding
ISO EXP
[DDT analog co-treated with Hexachlorocyclohexane analog co-treated with Chlorobenzenes co-treated with Mirex co-treated with Polychlorinated Biphenyls co-treated with Chlordan co-treated with Toxaphene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of ESR1 mRNA; [DDT results in increased activity of ESR1 protein] which results in decreased expression of GABRP mRNA; [DDT results in increased activity of ESR1 protein] which results in decreased expression of GSN mRNA; [DDT results in increased activity of ESR1 protein] which results in increased expression of BCL2 mRNA; [DDT results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA; [DDT results in increased activity of ESR1 protein] which results in increased expression of PGR mRNA; [DDT results in increased activity of ESR1 protein] which results in increased expression of SERPINB5 mRNA; [DDT results in increased activity of ESR1 protein] which results in increased expression of TFF1 mRNA; [Hexachlorocyclohexane co-treated with DDT] results in increased expression of ESR1; DDT binds to and results in increased activity of ESR1 protein DDT results in increased expression of ESR1 mRNA DDT results in decreased expression of ESR1 protein DDT results in increased methylation of ESR1 gene DDT promotes the reaction [ESR1 protein binds to CCND1 promoter]; DDT promotes the reaction [ESR1 protein binds to CDKN1A promoter] [o,p'-DDT co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Methoxychlor co-treated with Endosulfan co-treated with DDT] results in increased activity of ESR1 protein DDT binds to ESR1 protein DDT results in increased expression of ESR1 mRNA; DDT results in increased expression of ESR1 protein
CTD
PMID:9860891 PMID:11485867 PMID:12676605 PMID:15026083 PMID:15064155 PMID:15541753 PMID:16329587 PMID:16626760 PMID:18801367 PMID:19913605 PMID:21295777 PMID:22403704 PMID:23684557 PMID:25014179 PMID:26022396 PMID:26139245 PMID:26812056 PMID:28263910 PMID:29477483
NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
G
Esr2
estrogen receptor 2
multiple interactions increases activity
ISO EXP
DDT binds to and results in increased activity of ESR2 protein DDT results in increased activity of ESR2 protein [o,p'-DDT co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Methoxychlor co-treated with Endosulfan co-treated with DDT] results in increased activity of ESR2 protein
CTD
PMID:9860891 PMID:15064155 PMID:16626760 PMID:26139245 PMID:26812056
NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
G
Esrp1
epithelial splicing regulatory protein 1
increases methylation
EXP
DDT results in increased methylation of ESRP1 gene
CTD
PMID:30207508
NCBI chr 5:24,576,988...24,631,758
Ensembl chr 5:24,576,991...24,631,698
G
Fabp4
fatty acid binding protein 4
increases expression
ISO
DDT results in increased expression of FABP4 mRNA
CTD
PMID:25014179
NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
G
Fam102a
family with sequence similarity 102, member A
increases expression
ISO
DDT results in increased expression of FAM102A mRNA
CTD
PMID:14605097
NCBI chr 3:11,554,084...11,586,315
Ensembl chr 3:11,554,457...11,586,303
G
Fam171b
family with sequence similarity 171, member B
decreases expression
EXP
DDT results in decreased expression of FAM171B mRNA
CTD
PMID:30207508
NCBI chr 3:71,210,048...71,265,419
Ensembl chr 3:71,210,301...71,262,615
G
Fam174a
family with sequence similarity 174, member A
increases methylation
EXP
DDT results in increased methylation of FAM174A gene
CTD
PMID:30207508
NCBI chr 9:102,862,761...102,881,046
Ensembl chr 9:102,862,890...102,881,038
G
Fam50a
family with sequence similarity 50, member A
decreases expression
EXP
DDT results in decreased expression of FAM50A mRNA
CTD
PMID:30207508
NCBI chr X:156,392,646...156,399,763
Ensembl chr X:156,392,630...156,399,760
G
Fan1
FANCD2 and FANCI associated nuclease 1
increases methylation
EXP
DDT results in increased methylation of FAN1 gene
CTD
PMID:30207508
NCBI chr 1:125,182,117...125,209,772
Ensembl chr 1:125,181,838...125,209,727
G
Fap
fibroblast activation protein, alpha
increases methylation
EXP
DDT results in increased methylation of FAP gene
CTD
PMID:30207508
NCBI chr 3:48,467,781...48,536,242
Ensembl chr 3:48,467,781...48,536,235
G
Faslg
Fas ligand
increases expression
EXP
DDT results in increased expression of FASLG mRNA
CTD
PMID:29477483
NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
G
Fasn
fatty acid synthase
decreases expression
EXP
DDT results in decreased expression of FASN mRNA
CTD
PMID:29477483
NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
G
Fbxo32
F-box protein 32
decreases expression
EXP
DDT results in decreased expression of FBXO32 mRNA
CTD
PMID:30207508
NCBI chr 7:98,065,664...98,098,071
Ensembl chr 7:98,063,735...98,098,268
G
Fgd3
FYVE, RhoGEF and PH domain containing 3
increases methylation
EXP
DDT results in increased methylation of FGD3 gene
CTD
PMID:30207508
NCBI chr17:15,737,962...15,800,403
Ensembl chr17:15,749,978...15,800,401
G
Fgf2
fibroblast growth factor 2
decreases expression
ISO
DDT results in decreased expression of FGF2 mRNA
CTD
PMID:31521043
NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
G
Fgl2
fibrinogen-like 2
decreases expression
EXP
DDT results in decreased expression of FGL2 mRNA
CTD
PMID:30207508
NCBI chr 4:10,323,598...10,329,241
Ensembl chr 4:10,323,607...10,329,241
G
Filip1l
filamin A interacting protein 1-like
decreases expression
EXP
DDT results in decreased expression of FILIP1L mRNA
CTD
PMID:30207508
NCBI chr11:45,039,488...45,275,141
Ensembl chr11:45,039,461...45,124,423
G
Fn1
fibronectin 1
increases expression
ISO
DDT results in increased expression of FN1 protein
CTD
PMID:22902829
NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
G
Folh1
folate hydrolase 1
multiple interactions increases expression
ISO
DDT inhibits the reaction [Metribolone results in decreased expression of FOLH1 mRNA]; DDT inhibits the reaction [Metribolone results in decreased expression of FOLH1 protein] DDT results in increased expression of FOLH1 protein
CTD
PMID:25682698
NCBI chr 1:150,323,768...150,395,415
Ensembl chr 1:150,323,768...150,395,415
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
increases activity increases expression multiple interactions
ISO EXP
DDT results in increased activity of FOS protein DDT results in increased expression of FOS mRNA [Permethrin co-treated with DDT co-treated with Diethylstilbestrol] inhibits the reaction [Potassium results in increased expression of FOS mRNA]; DDT inhibits the reaction [Potassium results in increased expression of FOS mRNA]; DDT promotes the reaction [FOS protein binds to CCND1 promoter]; fulvestrant inhibits the reaction [DDT results in increased expression of FOS mRNA]
CTD
PMID:14604893 PMID:15527870 PMID:23684557 PMID:25014179 PMID:28263910 PMID:30207508
NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
G
Fosb
FosB proto-oncogene, AP-1 transcription factor subunit
increases expression
EXP
DDT results in increased expression of FOSB mRNA
CTD
PMID:30207508
NCBI chr 1:80,214,691...80,221,417
Ensembl chr 1:80,214,494...80,221,710
G
Fosl1
FOS like 1, AP-1 transcription factor subunit
increases expression
ISO
DDT results in increased expression of FOSL1 mRNA
CTD
PMID:18791200
NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
G
Foxp2
forkhead box P2
decreases expression
EXP
DDT results in decreased expression of FOXP2 mRNA
CTD
PMID:30207508
NCBI chr 4:41,364,441...41,944,685
Ensembl chr 4:41,364,441...41,942,023
G
Frmd3
FERM domain containing 3
decreases expression
EXP
DDT results in decreased expression of FRMD3 mRNA
CTD
PMID:30207508
NCBI chr 5:90,040,495...90,282,327
Ensembl chr 5:90,040,495...90,282,327
G
Fryl
FRY like transcription coactivator
increases methylation
EXP
DDT results in increased methylation of FRYL gene
CTD
PMID:30207508
NCBI chr14:37,551,109...37,757,511
Ensembl chr14:37,551,940...37,756,149
G
Fshb
follicle stimulating hormone subunit beta
multiple interactions increases expression
EXP ISO
DDT inhibits the reaction [FSHB protein binds to FSHR protein] DDT promotes the reaction [[FSHB protein results in increased activity of FSHR protein] which results in increased abundance of Cyclic AMP] DDT results in increased expression of FSHB mRNA; DDT results in increased expression of FSHB protein 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [DDT results in increased expression of FSHB mRNA]
CTD
PMID:17157474 PMID:24814263 PMID:26895433
NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
G
Fshr
follicle stimulating hormone receptor
affects activity decreases activity multiple interactions
EXP ISO
DDT affects the activity of FSHR protein DDT results in decreased activity of FSHR protein DDT promotes the reaction [[CGA protein results in increased activity of FSHR protein] which results in increased abundance of Cyclic AMP]; DDT promotes the reaction [[FSHB protein results in increased activity of FSHR protein] which results in increased abundance of Cyclic AMP] DDT inhibits the reaction [FSHB protein binds to FSHR protein]
CTD
PMID:17157474 PMID:26895433
NCBI chr 6:12,796,383...12,997,817
Ensembl chr 6:12,796,383...12,997,817
G
G6pd
glucose-6-phosphate dehydrogenase
increases activity multiple interactions
EXP
DDT results in increased activity of G6PD protein Inositol inhibits the reaction [DDT results in increased activity of G6PD protein]
CTD
PMID:12667599
NCBI chr X:156,274,800...156,293,935
Ensembl chr X:156,274,800...156,293,926
G
Gabbr2
gamma-aminobutyric acid type B receptor subunit 2
decreases expression
EXP
DDT results in decreased expression of GABBR2 mRNA
CTD
PMID:19797855
NCBI chr 5:62,276,100...62,621,737
Ensembl chr 5:62,276,100...62,621,737
G
Gabrg3
gamma-aminobutyric acid type A receptor subunit gamma 3
decreases methylation
EXP
DDT results in decreased methylation of GABRG3 gene
CTD
PMID:30207508
NCBI chr 1:112,158,525...112,812,267
Ensembl chr 1:112,158,519...112,811,936
G
Gabrp
gamma-aminobutyric acid type A receptor subunit pi
multiple interactions
ISO
[DDT results in increased activity of ESR1 protein] which results in decreased expression of GABRP mRNA
CTD
PMID:22403704
NCBI chr10:18,484,257...18,510,604
Ensembl chr10:18,485,514...18,506,337
G
Gadd45b
growth arrest and DNA-damage-inducible, beta
multiple interactions increases expression
ISO
Androstanols inhibits the reaction [DDT results in increased expression of GADD45B mRNA]; DDT promotes the reaction [GADD45B protein binds to CYP2B10 promoter] DDT results in increased expression of GADD45B mRNA; DDT results in increased expression of GADD45B protein
CTD
PMID:23684557
NCBI chr 7:11,646,283...11,648,338
Ensembl chr 7:11,646,269...11,648,322
G
Gal
galanin and GMAP prepropeptide
decreases expression
EXP
DDT results in decreased expression of GAL mRNA
CTD
PMID:19797855
NCBI chr 1:218,653,059...218,657,922
Ensembl chr 1:218,652,917...218,657,925
G
Gas5
growth arrest specific 5
decreases expression
ISO
DDT results in decreased expression of GAS5 mRNA
CTD
PMID:25014179
NCBI chr13:78,852,523...78,855,844
G
Gcc2
GRIP and coiled-coil domain containing 2
decreases expression
EXP
DDT results in decreased expression of GCC2 mRNA
CTD
PMID:30207508
NCBI chr20:27,832,960...27,879,764
Ensembl chr20:27,832,932...27,879,759
G
Gclc
glutamate-cysteine ligase, catalytic subunit
increases expression
ISO EXP
DDT results in increased expression of GCLC mRNA
CTD
PMID:26198647 PMID:29477483
NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
G
Gclm
glutamate cysteine ligase, modifier subunit
increases expression
ISO
DDT results in increased expression of GCLM mRNA
CTD
PMID:26198647
NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
G
Gcnt4
glucosaminyl (N-acetyl) transferase 4
increases methylation
EXP
DDT results in increased methylation of GCNT4 gene
CTD
PMID:30207508
Ensembl chr 2:27,713,880...27,780,119
G
Gfra1
GDNF family receptor alpha 1
multiple interactions
ISO
[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of GFRA1 mRNA
CTD
PMID:28263720
NCBI chr 1:279,203,046...279,572,789
G
Ggt1
gamma-glutamyltransferase 1
decreases activity increases activity
EXP
DDT results in decreased activity of GGT1 protein DDT results in increased activity of GGT1 protein
CTD
PMID:2387028 PMID:9475050
NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
G
Ghr
growth hormone receptor
decreases expression
EXP
DDT results in decreased expression of GHR mRNA
CTD
PMID:30207508
NCBI chr 2:53,149,225...53,413,954
Ensembl chr 2:53,150,370...53,413,638
G
Gja1
gap junction protein, alpha 1
multiple interactions increases degradation decreases expression
ISO EXP
[DDT co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of GJA1 protein DDT results in increased degradation of GJA1 protein; DDT results in increased degradation of GJA1 protein modified form Chloroquine inhibits the reaction [DDT results in increased degradation of GJA1 protein modified form]; Colchicine inhibits the reaction [DDT results in increased degradation of GJA1 protein modified form]; DDT results in decreased expression of and results in increased phosphorylation of GJA1 protein DDT results in decreased expression of GJA1 protein; DDT results in decreased expression of GJA1 protein modified form
CTD
PMID:8285856 PMID:8313522 PMID:8820588 PMID:8824497 PMID:15082077
NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
G
Gjb1
gap junction protein, beta 1
multiple interactions decreases expression
EXP
[DDT co-treated with Diethylnitrosamine] results in decreased expression of GJB1 mRNA; [DDT co-treated with Diethylnitrosamine] results in increased expression of GJB1 mRNA DDT results in decreased expression of GJB1 protein
CTD
PMID:8242434 PMID:15885732
NCBI chr X:71,272,030...71,279,973
Ensembl chr X:71,272,042...71,279,977
G
Gnrh1
gonadotropin releasing hormone 1
multiple interactions
ISO
[Hexachlorocyclohexane co-treated with DDT] results in increased expression of GNRH1
CTD
PMID:16329587
NCBI chr15:44,441,856...44,446,064
Ensembl chr15:44,442,555...44,442,875 Ensembl chr15:44,442,555...44,442,875
G
Golgb1
golgin B1
decreases expression
EXP
DDT results in decreased expression of GOLGB1 mRNA
CTD
PMID:30207508
NCBI chr11:66,761,646...66,819,115
Ensembl chr11:66,761,584...66,819,079
G
Golim4
golgi integral membrane protein 4
decreases expression
EXP
DDT results in decreased expression of GOLIM4 mRNA
CTD
PMID:30207508
NCBI chr 2:174,321,303...174,413,847
Ensembl chr 2:174,322,673...174,413,236
G
Gpat3
glycerol-3-phosphate acyltransferase 3
increases expression
ISO
DDT results in increased expression of GPAT3 mRNA
CTD
PMID:26198647
NCBI chr14:10,343,287...10,396,565
Ensembl chr14:10,343,282...10,395,047
G
Gpc3
glypican 3
increases expression
EXP
DDT results in increased expression of GPC3 mRNA
CTD
PMID:30207508
NCBI chr X:139,579,268...139,947,093
Ensembl chr X:139,579,268...139,916,883
G
Gper1
G protein-coupled estrogen receptor 1
affects binding affects expression decreases expression increases methylation
ISO
DDT binds to GPER1 protein DDT affects the expression of GPER1 mRNA DDT results in decreased expression of GPER1 protein DDT results in increased methylation of GPER1 gene
CTD
PMID:17088055 PMID:28263910
NCBI chr12:17,309,122...17,315,267
Ensembl chr12:17,309,834...17,311,112
G
Gpnmb
glycoprotein nmb
increases methylation
EXP
DDT results in increased methylation of GPNMB gene
CTD
PMID:30207508
NCBI chr 4:78,694,447...78,715,685
Ensembl chr 4:78,694,447...78,715,683
G
Gpt
glutamic--pyruvic transaminase
increases activity
EXP
DDT results in increased activity of GPT protein
CTD
PMID:2387028
NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
G
Grb2
growth factor receptor bound protein 2
multiple interactions
ISO
DDT promotes the reaction [GRB2 protein binds to SOS1 protein]
CTD
PMID:9070211
NCBI chr10:104,193,953...104,263,071
Ensembl chr10:104,193,955...104,263,071
G
Grifin
galectin-related inter-fiber protein
increases expression
EXP
DDT results in increased expression of GRIFIN mRNA
CTD
PMID:19797855
NCBI chr12:16,170,108...16,172,144
Ensembl chr12:16,170,162...16,172,129
G
Grm1
glutamate metabotropic receptor 1
decreases methylation
EXP
DDT results in decreased methylation of GRM1 gene
CTD
PMID:30207508
NCBI chr 1:4,753,141...5,165,859
Ensembl chr 1:4,753,144...5,165,859
G
Gsk3b
glycogen synthase kinase 3 beta
increases phosphorylation multiple interactions
ISO
DDT results in increased phosphorylation of GSK3B protein Acetylcysteine inhibits the reaction [DDT results in increased phosphorylation of GSK3B protein]
CTD
PMID:24968063
NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
G
Gsn
gelsolin
multiple interactions
ISO
[DDT results in increased activity of ESR1 protein] which results in decreased expression of GSN mRNA
CTD
PMID:22403704
NCBI chr 3:14,456,106...14,508,922
Ensembl chr 3:14,467,330...14,508,911
G
Gsta1
glutathione S-transferase alpha 1
increases expression
EXP
DDT results in increased expression of GSTA1 mRNA
CTD
PMID:30207508
NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
G
Gsta2
glutathione S-transferase alpha 2
increases expression
EXP
DDT results in increased expression of GSTA2 mRNA
CTD
PMID:29477483
NCBI chr 8:85,640,081...85,645,621
G
Gsto1
glutathione S-transferase omega 1
increases expression
ISO
DDT results in increased expression of GSTO1 mRNA
CTD
PMID:31521043
NCBI chr 1:267,607,437...267,617,387
Ensembl chr 1:267,607,418...267,617,387
G
Herpud2
HERPUD family member 2
increases methylation
EXP
DDT results in increased methylation of HERPUD2 gene
CTD
PMID:30207508
NCBI chr 8:26,266,571...26,311,528
Ensembl chr 8:26,266,760...26,311,350
G
Hgf
hepatocyte growth factor
decreases expression
ISO
DDT results in decreased expression of HGF mRNA
CTD
PMID:25014179
NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
G
Hipk3
homeodomain interacting protein kinase 3
increases methylation
EXP
DDT results in increased methylation of HIPK3 gene
CTD
PMID:30207508
NCBI chr 3:94,349,778...94,419,185
Ensembl chr 3:94,352,969...94,419,048
G
Hmox1
heme oxygenase 1
increases expression
ISO
DDT results in increased expression of HMOX1 mRNA
CTD
PMID:31521043
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
G
Hnf1a
HNF1 homeobox A
multiple interactions
EXP
[DDT co-treated with Diethylnitrosamine] results in decreased expression of HNF1A mRNA; [DDT co-treated with Diethylnitrosamine] results in increased expression of HNF1A mRNA
CTD
PMID:15885732
NCBI chr12:47,407,811...47,433,342
Ensembl chr12:47,407,811...47,433,342
G
Hook3
hook microtubule-tethering protein 3
decreases expression
EXP
DDT results in decreased expression of HOOK3 mRNA
CTD
PMID:30207508
NCBI chr16:70,710,347...70,818,789
G
Hs3st2
heparan sulfate-glucosamine 3-sulfotransferase 2
decreases methylation
EXP
DDT results in decreased methylation of HS3ST2 gene
CTD
PMID:30207508
NCBI chr 1:191,344,979...191,474,143
Ensembl chr 1:191,344,979...191,474,142
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Hsd17b1
hydroxysteroid (17-beta) dehydrogenase 1
decreases expression multiple interactions
ISO
DDT results in decreased expression of HSD17B1 mRNA MT2A protein inhibits the reaction [DDT results in decreased expression of HSD17B1 mRNA]
CTD
PMID:12858341
NCBI chr10:88,987,558...88,989,758
Ensembl chr10:88,987,558...88,989,757
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Hsd3b1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
increases expression
ISO
DDT results in increased expression of HSD3B1 mRNA
CTD
PMID:12858341
G
Hsp90ab1
heat shock protein 90 alpha family class B member 1
decreases expression
EXP
DDT results in decreased expression of HSP90AB1 mRNA
CTD
PMID:19797855
NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
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Hspa4
heat shock protein family A (Hsp70) member 4
decreases expression
EXP
DDT results in decreased expression of HSPA4 mRNA
CTD
PMID:19797855
NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397
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Hspa5
heat shock protein family A (Hsp70) member 5
increases expression
ISO EXP
DDT results in increased expression of HSPA5 mRNA
CTD
PMID:15710169 PMID:29477483
NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
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Htr1a
5-hydroxytryptamine receptor 1A
decreases expression
ISO
DDT results in decreased expression of HTR1A mRNA
CTD
PMID:28263910
NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
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Ibsp
integrin-binding sialoprotein
increases methylation
EXP
DDT results in increased methylation of IBSP gene
CTD
PMID:30207508
NCBI chr14:6,801,200...6,813,987
Ensembl chr14:6,801,204...6,813,945
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Ide
insulin degrading enzyme
decreases activity
ISO
DDT results in decreased activity of IDE protein
CTD
PMID:25720399
NCBI chr 1:255,914,465...256,014,168
Ensembl chr 1:255,914,447...256,013,495
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Ifit2
interferon-induced protein with tetratricopeptide repeats 2
decreases expression
ISO
DDT results in decreased expression of IFIT2 mRNA
CTD
PMID:25014179
NCBI chr 1:252,894,663...252,900,727
Ensembl chr 1:252,894,663...252,900,726
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Igf1
insulin-like growth factor 1
multiple interactions decreases expression increases methylation
ISO EXP
DDT affects the reaction [Metribolone results in increased expression of IGF1 mRNA] DDT results in decreased expression of IGF1 mRNA DDT results in increased methylation of IGF1 gene
CTD
PMID:25682698 PMID:30207508 PMID:30822522
NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
G
Igf2
insulin-like growth factor 2
decreases expression
EXP
DDT results in decreased expression of IGF2 mRNA
CTD
PMID:19797855
NCBI chr 1:215,828,102...215,839,081
Ensembl chr 1:215,828,102...215,846,911
G
Il1b
interleukin 1 beta
decreases expression increases secretion multiple interactions
ISO
DDT metabolite results in decreased expression of IL1B mRNA; DDT results in decreased expression of IL1B mRNA DDT results in increased secretion of IL1B protein [DDT co-treated with o,p'-DDT] results in decreased expression of IL1B mRNA
CTD
PMID:12007859 PMID:27592000
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
G
Il1r1
interleukin 1 receptor type 1
increases expression decreases expression
EXP
DDT results in increased expression of IL1R1 mRNA DDT results in decreased expression of IL1R1 mRNA
CTD
PMID:11948501
NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670
G
Il2
interleukin 2
decreases expression
ISO
DDT results in decreased expression of IL2 mRNA; DDT results in decreased expression of IL2 protein
CTD
PMID:16696175
NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
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Il4
interleukin 4
multiple interactions
ISO
[DDT co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of IL4 protein
CTD
PMID:12696651
NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
G
Il6
interleukin 6
decreases expression multiple interactions increases expression
EXP ISO
DDT results in decreased expression of IL6 mRNA 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [DDT results in increased expression of and results in increased secretion of IL6 protein]; DDT results in increased expression of and results in increased secretion of IL6 protein DDT results in increased expression of IL6 mRNA
CTD
PMID:29477483 PMID:31542660
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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Inhbc
inhibin subunit beta C
decreases methylation
EXP
DDT results in decreased methylation of INHBC gene
CTD
PMID:30207508
NCBI chr 7:70,648,005...70,661,475
Ensembl chr 7:70,646,519...70,661,891
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Insr
insulin receptor
decreases methylation
EXP
DDT results in decreased methylation of INSR gene
CTD
PMID:30207508
NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
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Itga5
integrin subunit alpha 5
increases expression
ISO
DDT results in increased expression of ITGA5 mRNA
CTD
PMID:22902829
NCBI chr 7:144,970,444...144,993,652
Ensembl chr 7:144,970,444...144,993,652
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Itga9
integrin subunit alpha 9
increases expression
EXP
DDT results in increased expression of ITGA9 mRNA
CTD
PMID:30207508
NCBI chr 8:127,271,029...127,576,709
Ensembl chr 8:127,271,289...127,572,988
G
Itgb1
integrin subunit beta 1
multiple interactions increases expression
ISO
Acetylcysteine inhibits the reaction [DDT results in increased expression of ITGB1 mRNA]; INCB018424 inhibits the reaction [DDT results in increased expression of ITGB1 mRNA]; WP1066 inhibits the reaction [DDT results in increased expression of ITGB1 mRNA]
CTD
PMID:24820114
NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
G
Jak1
Janus kinase 1
multiple interactions increases phosphorylation
ISO
Acetylcysteine inhibits the reaction [DDT results in increased phosphorylation of JAK1 protein]; INCB018424 inhibits the reaction [DDT results in increased phosphorylation of JAK1 protein]
CTD
PMID:24820114
NCBI chr 5:119,982,503...120,091,452
Ensembl chr 5:119,982,943...120,083,904
G
Jun
Jun proto-oncogene, AP-1 transcription factor subunit
increases activity increases expression
ISO
DDT results in increased activity of JUN protein DDT results in increased expression of JUN protein
CTD
PMID:14604893
NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
G
Junb
JunB proto-oncogene, AP-1 transcription factor subunit
increases expression
EXP
DDT results in increased expression of JUNB mRNA
CTD
PMID:30207508
NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
G
Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity
ISO
DDT results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
G
Kdm7a
lysine demethylase 7A
decreases expression
EXP
DDT results in decreased expression of KDM7A mRNA
CTD
PMID:30207508
NCBI chr 4:66,915,603...66,957,971
Ensembl chr 4:66,922,013...66,955,732
G
Kit
KIT proto-oncogene receptor tyrosine kinase
multiple interactions
ISO
[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of KIT mRNA
CTD
PMID:28263720
NCBI chr14:35,072,131...35,149,638
Ensembl chr14:35,072,108...35,149,610
G
Klk13
kallikrein related-peptidase 13
increases methylation
EXP
DDT results in increased methylation of KLK13 gene
CTD
PMID:30207508
NCBI chr 1:99,648,658...99,661,025
Ensembl chr 1:99,648,658...99,660,277
G
Krt18
keratin 18
decreases expression
ISO
DDT results in decreased expression of KRT18 protein
CTD
PMID:26186133
NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
G
Krt34
keratin 34
decreases expression
ISO
DDT results in decreased expression of KRT34 mRNA
CTD
PMID:25014179
NCBI chr10:87,950,364...87,954,055
Ensembl chr10:87,950,001...87,954,055
G
Krt8
keratin 8
decreases expression
ISO
DDT results in decreased expression of KRT8 protein
CTD
PMID:26186133
NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803
G
Krtap16-1
keratin associated protein 16-1
increases methylation
EXP
DDT results in increased methylation of KRTAP16-1 gene
CTD
PMID:30207508
NCBI chr10:87,919,100...87,920,581
Ensembl chr10:87,919,100...87,920,581 Ensembl chr10:87,919,100...87,920,581
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Ktn1
kinectin 1
increases expression
ISO
DDT results in increased expression of KTN1 mRNA
CTD
PMID:25014179
NCBI chr15:24,465,761...24,552,833
Ensembl chr15:24,479,761...24,553,197
G
Lbh
LBH regulator of WNT signaling pathway
increases expression
ISO
DDT results in increased expression of LBH mRNA
CTD
PMID:24814263
NCBI chr 6:24,154,207...24,184,217
Ensembl chr 6:24,160,226...24,181,866
G
Ldha
lactate dehydrogenase A
increases expression multiple interactions
ISO
DDT results in increased expression of LDHA mRNA 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [DDT results in increased expression of LDHA mRNA]; Acetylcysteine inhibits the reaction [DDT results in increased expression of LDHA mRNA]; PKM protein alternative form affects the reaction [DDT results in increased expression of LDHA mRNA]
CTD
PMID:31724279
NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707
G
Lep
leptin
increases expression
ISO
DDT results in increased expression of LEP mRNA
CTD
PMID:25014179
NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
G
Lgi2
leucine-rich repeat LGI family, member 2
decreases methylation
EXP
DDT results in decreased methylation of LGI2 gene
CTD
PMID:30207508
NCBI chr14:60,764,325...60,791,809
Ensembl chr14:60,764,409...60,796,116
G
Lhb
luteinizing hormone subunit beta
multiple interactions increases expression
ISO
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [DDT results in increased expression of LHB mRNA] DDT results in increased expression of LHB protein
CTD
PMID:24814263
NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
G
Lif
LIF, interleukin 6 family cytokine
increases expression
ISO
DDT results in increased expression of LIF mRNA
CTD
PMID:26198647
NCBI chr14:84,482,652...84,500,574
Ensembl chr14:84,482,674...84,500,642
G
Lmbrd2
LMBR1 domain containing 2
decreases expression
EXP
DDT results in decreased expression of LMBRD2 mRNA
CTD
PMID:30207508
NCBI chr 2:58,534,474...58,590,767
Ensembl chr 2:58,534,476...58,590,758
G
Lnpep
leucyl and cystinyl aminopeptidase
decreases expression
EXP
DDT results in decreased expression of LNPEP mRNA
CTD
PMID:30207508
NCBI chr 1:59,289,392...59,384,540
Ensembl chr 1:59,297,294...59,347,472 Ensembl chr 1:59,297,294...59,347,472
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LOC100362109
hypothetical protein LOC100362109
decreases expression
ISO
DDT results in decreased expression of C22ORF46 mRNA
CTD
PMID:25014179
NCBI chr 7:123,295,519...123,304,163
Ensembl chr 7:123,296,183...123,304,066
G
Lox
lysyl oxidase
decreases expression
EXP
DDT results in decreased expression of LOX mRNA
CTD
PMID:30207508
NCBI chr18:47,500,320...47,577,819
Ensembl chr18:47,500,330...47,577,819
G
Loxhd1
lipoxygenase homology domains 1
increases methylation
EXP
DDT results in increased methylation of LOXHD1 gene
CTD
PMID:30207508
NCBI chr18:73,645,365...73,812,271
Ensembl chr18:73,645,907...73,812,271
G
Lpl
lipoprotein lipase
increases expression
ISO
DDT results in increased expression of LPL mRNA
CTD
PMID:25014179
NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
G
Lpp
LIM domain containing preferred translocation partner in lipoma
decreases expression decreases methylation
EXP
DDT results in decreased expression of LPP mRNA DDT results in decreased methylation of LPP gene
CTD
PMID:30207508
NCBI chr11:79,192,603...79,827,858
Ensembl chr11:79,205,730...79,703,736
G
Lratd2
LRAT domain containing 2
decreases methylation
EXP
DDT results in decreased methylation of LRATD2 gene
CTD
PMID:30207508
NCBI chr 7:101,138,188...101,142,123
Ensembl chr 7:101,139,376...101,140,308
G
Lrrc2
leucine rich repeat containing 2
multiple interactions
ISO
[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of LRRC2 mRNA
CTD
PMID:28263720
NCBI chr 8:119,226,651...119,259,649
Ensembl chr 8:119,228,612...119,259,645
G
Lrrfip1
LRR binding FLII interacting protein 1
decreases expression
EXP
DDT results in decreased expression of LRRFIP1 mRNA
CTD
PMID:30207508
NCBI chr 9:98,139,484...98,268,148
Ensembl chr 9:98,190,829...98,257,735
G
Ltf
lactotransferrin
increases expression
ISO
DDT results in increased expression of LTF mRNA
CTD
PMID:9607801
NCBI chr 8:119,290,416...119,313,261
Ensembl chr 8:119,290,416...119,313,261
G
Lum
lumican
increases expression
EXP
DDT results in increased expression of LUM mRNA
CTD
PMID:30207508
NCBI chr 7:38,820,058...38,826,862
Ensembl chr 7:38,819,771...38,826,862
G
Luzp2
leucine zipper protein 2
decreases methylation
EXP
DDT results in decreased methylation of LUZP2 gene
CTD
PMID:30207508
NCBI chr 1:111,849,494...112,067,502 NCBI chr 1:113,419,707...113,531,330
Ensembl chr 1:111,849,998...113,527,735
G
Ly86
lymphocyte antigen 86
increases methylation
EXP
DDT results in increased methylation of LY86 gene
CTD
PMID:30207508
NCBI chr17:28,104,535...28,191,447
Ensembl chr17:28,104,589...28,191,436
G
Ly9
lymphocyte antigen 9
increases methylation
EXP
DDT results in increased methylation of LY9 gene
CTD
PMID:30207508
NCBI chr13:90,002,779...90,022,346
Ensembl chr13:90,002,783...90,022,269
G
M1ap
meiosis 1 associated protein
increases methylation
EXP
DDT results in increased methylation of M1AP gene
CTD
PMID:30207508
NCBI chr 4:113,772,716...113,864,171
Ensembl chr 4:113,782,206...113,863,224
G
Mab21l1
mab-21 like 1
decreases expression
EXP
DDT results in decreased expression of MAB21L1 mRNA
CTD
PMID:30207508
NCBI chr 2:145,174,876...145,177,265
Ensembl chr 2:145,174,876...145,177,265
G
Mageb1
melanoma antigen family B, 1
increases methylation
EXP
DDT results in increased methylation of MAGEB4 gene
CTD
PMID:30207508
NCBI chr X:54,892,482...54,931,144
G
Manea
mannosidase, endo-alpha
decreases expression
EXP
DDT results in decreased expression of MANEA mRNA
CTD
PMID:30207508
NCBI chr 5:40,845,103...40,867,025
Ensembl chr 5:40,844,998...40,867,023
G
Map2
microtubule-associated protein 2
decreases expression
EXP
DDT results in decreased expression of MAP2 mRNA
CTD
PMID:30207508
NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972
G
Map2k6
mitogen-activated protein kinase kinase 6
multiple interactions
ISO
MAP2K6 protein promotes the reaction [DDT results in increased activity of NOTCH1 protein]
CTD
PMID:18791200
NCBI chr10:98,707,160...98,823,054
Ensembl chr10:98,706,960...98,823,287
G
Mapk1
mitogen activated protein kinase 1
increases phosphorylation multiple interactions increases activity
ISO EXP
DDT results in increased phosphorylation of MAPK1 protein 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [DDT results in increased phosphorylation of MAPK1 protein] 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [DDT results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [DDT results in increased phosphorylation of MAPK1 protein]; DDT results in increased phosphorylation of and results in increased activity of MAPK1 protein DDT results in increased activity of MAPK1 protein
CTD
PMID:9070211 PMID:12523960 PMID:14604893 PMID:24814263 PMID:31724279
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
G
Mapk14
mitogen activated protein kinase 14
increases phosphorylation
ISO
DDT results in increased phosphorylation of MAPK14 protein
CTD
PMID:14604893
NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
G
Mapk3
mitogen activated protein kinase 3
increases phosphorylation multiple interactions
ISO
DDT results in increased phosphorylation of MAPK3 protein 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [DDT results in increased phosphorylation of MAPK3 protein] 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [DDT results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [DDT results in increased phosphorylation of MAPK3 protein]; DDT results in increased phosphorylation of and results in increased activity of MAPK3 protein
CTD
PMID:9070211 PMID:14604893 PMID:24814263 PMID:31724279
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
G
Mapk8
mitogen-activated protein kinase 8
decreases phosphorylation
ISO
DDT results in decreased phosphorylation of MAPK8 protein
CTD
PMID:14604893
NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
G
Mapk8ip3
mitogen-activated protein kinase 8 interacting protein 3
increases expression
ISO
DDT results in increased expression of MAPK8IP3 mRNA
CTD
PMID:25014179
NCBI chr10:14,259,394...14,299,276
Ensembl chr10:14,260,787...14,299,167
G
Mapk9
mitogen-activated protein kinase 9
decreases phosphorylation
ISO
DDT results in decreased phosphorylation of MAPK9 protein
CTD
PMID:14604893
NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
G
Matr3
matrin 3
decreases expression
EXP
DDT results in decreased expression of MATR3 mRNA
CTD
PMID:30207508
NCBI chr18:28,351,691...28,390,764
Ensembl chr18:28,361,283...28,390,717
G
Mcm4
minichromosome maintenance complex component 4
decreases expression
ISO
DDT results in decreased expression of MCM4 mRNA
CTD
PMID:25014179
NCBI chr11:89,511,191...89,524,892
Ensembl chr11:89,511,191...89,524,892
G
Mcur1
mitochondrial calcium uniporter regulator 1
increases methylation
EXP
DDT results in increased methylation of MCUR1 gene
CTD
PMID:30207508
NCBI chr17:24,165,259...24,182,425
Ensembl chr17:24,165,280...24,182,425
G
Mdm2
MDM2 proto-oncogene
multiple interactions increases expression
ISO
Androstanols inhibits the reaction [DDT results in increased expression of MDM2 mRNA] DDT results in increased expression of MDM2 mRNA; DDT results in increased expression of MDM2 protein
CTD
PMID:23684557
NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
G
Mepe
matrix extracellular phosphoglycoprotein
increases methylation
EXP
DDT results in increased methylation of MEPE gene
CTD
PMID:30207508
NCBI chr14:6,782,011...6,793,561
Ensembl chr14:6,782,012...6,793,558
G
Mertk
MER proto-oncogene, tyrosine kinase
multiple interactions
ISO
[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of MERTK mRNA
CTD
PMID:28263720
NCBI chr 3:121,235,230...121,340,932
Ensembl chr 3:121,235,119...121,342,444
G
Met
MET proto-oncogene, receptor tyrosine kinase
increases phosphorylation
ISO
DDT results in increased phosphorylation of MET protein
CTD
PMID:9070211
NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
G
Mfap3l
microfibril associated protein 3 like
decreases expression
EXP
DDT results in decreased expression of MFAP3L mRNA
CTD
PMID:30207508
NCBI chr16:32,734,059...32,777,091
Ensembl chr16:32,738,265...32,753,278
G
Mgp
matrix Gla protein
increases expression
EXP
DDT results in increased expression of MGP mRNA
CTD
PMID:30207508
NCBI chr 4:170,856,783...170,860,105
Ensembl chr 4:170,856,751...170,860,225
G
Mir15b
microRNA 15b
decreases expression
ISO
DDT results in decreased expression of MIR15B mRNA
CTD
PMID:22403704
NCBI chr 2:165,605,923...165,606,020
Ensembl chr 2:165,605,923...165,606,020
G
Mir190
microRNA 190
increases expression
EXP
DDT results in increased expression of MIR190 mRNA
CTD
PMID:30421125
NCBI chr 8:73,030,047...73,030,131
Ensembl chr 8:73,030,047...73,030,131
G
Mir190b
microRNA 190b
increases expression
ISO EXP
DDT results in increased expression of MIR190B mRNA
CTD
PMID:30421125
NCBI chr 2:189,421,137...189,421,214
Ensembl chr 2:189,421,137...189,421,214
G
Mir193a
microRNA 193a
increases expression
ISO
DDT results in increased expression of MIR193A mRNA
CTD
PMID:22403704
NCBI chr10:67,065,885...67,065,996
Ensembl chr10:67,065,885...67,065,996
G
Mir202
microRNA 202
increases expression
EXP
DDT results in increased expression of MIR202 mRNA
CTD
PMID:30207508
NCBI chr 1:212,295,630...212,295,701
Ensembl chr 1:212,295,630...212,295,701
G
Mir21
microRNA 21
decreases expression
ISO
DDT results in decreased expression of MIR21 mRNA
CTD
PMID:22403704
NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
G
Mir27b
microRNA 27b
decreases expression
ISO
DDT results in decreased expression of MIR27B mRNA
CTD
PMID:22403704
NCBI chr17:823,461...823,557
Ensembl chr17:823,461...823,557
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Mir342
microRNA 342
decreases expression
ISO
DDT results in decreased expression of MIR342 mRNA
CTD
PMID:22403704
NCBI chr 6:132,561,169...132,561,267
Ensembl chr 6:132,561,169...132,561,267
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Mir34b
microRNA 34b
decreases expression
EXP
DDT results in decreased expression of MIR34B mRNA
CTD
PMID:30207508
NCBI chr 8:55,492,542...55,492,625
Ensembl chr 8:55,492,542...55,492,625
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Mir34c
microRNA 34c
decreases expression
EXP
DDT results in decreased expression of MIR34C mRNA
CTD
PMID:30207508
NCBI chr 8:55,492,024...55,492,100
Ensembl chr 8:55,492,024...55,492,100
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Mir374b
microRNA 374b
increases expression
EXP
DDT results in increased expression of MIR374 mRNA
CTD
PMID:30207508
NCBI chr X:74,443,648...74,443,715
Ensembl chr X:74,443,648...74,443,715
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Mir6333
microRNA 6333
increases methylation
EXP
DDT results in increased methylation of MIR6333 gene
CTD
PMID:30207508
NCBI chr 5:153,843,901...153,844,011
Ensembl chr 5:153,843,901...153,844,011
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Mir92b
microRNA 92b
decreases expression
ISO
DDT results in decreased expression of MIR92B mRNA
CTD
PMID:22403704
NCBI chr 2:188,541,034...188,541,116
Ensembl chr 2:188,541,034...188,541,116
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Mir99b
microRNA 99b
decreases expression
ISO
DDT results in decreased expression of MIR99B mRNA
CTD
PMID:22403704
NCBI chr 1:59,704,216...59,704,285
Ensembl chr 1:59,704,216...59,704,285
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Mirlet7b
microRNA let-7b
decreases expression
EXP
DDT results in decreased expression of MIRLET7B mRNA
CTD
PMID:30207508
NCBI chr 7:126,590,627...126,590,711
Ensembl chr 7:126,590,627...126,590,711
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Mitf
melanocyte inducing transcription factor
increases methylation
EXP
DDT results in increased methylation of MITF gene
CTD
PMID:30207508
NCBI chr 4:130,172,484...130,425,496
Ensembl chr 4:130,172,727...130,425,532
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Mmadhc
metabolism of cobalamin associated D
increases methylation
EXP
DDT results in increased methylation of MMADHC gene
CTD
PMID:30207508
NCBI chr 3:35,783,511...35,801,474
Ensembl chr 3:35,783,623...35,801,614
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Mme
membrane metallo-endopeptidase
decreases expression
EXP
DDT results in decreased expression of MME mRNA
CTD
PMID:30207508
NCBI chr 2:153,799,203...153,880,910
Ensembl chr 2:153,803,349...153,880,738
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Mmp2
matrix metallopeptidase 2
increases expression
EXP
DDT results in increased expression of MMP2 mRNA
CTD
PMID:30207508
NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
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Mmp3
matrix metallopeptidase 3
multiple interactions increases expression
ISO
13-hydroxy-10-oxo-11-octadecenoic acid inhibits the reaction [DDT results in increased expression of MMP3 mRNA]; zerumbone inhibits the reaction [DDT results in increased expression of MMP3 mRNA]
CTD
PMID:20865247
NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
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Mogs
mannosyl-oligosaccharide glucosidase
decreases expression
EXP
DDT results in decreased expression of MOGS mRNA
CTD
PMID:30207508
NCBI chr 4:113,948,328...113,951,731
Ensembl chr 4:113,948,514...113,951,847
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Msx1
msh homeobox 1
decreases expression
EXP
DDT results in decreased expression of MSX1 mRNA
CTD
PMID:19797855
NCBI chr14:77,712,262...77,716,061
Ensembl chr14:77,712,240...77,716,059
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Mt2A
metallothionein 2A
multiple interactions decreases expression
ISO
MT2A protein inhibits the reaction [DDT results in decreased expression of HSD17B1 mRNA] DDT results in decreased expression of MT2A mRNA
CTD
PMID:12858341 PMID:25014179
NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
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Muc6
mucin 6, oligomeric mucus/gel-forming
increases methylation
EXP
DDT results in increased methylation of MUC6 gene
CTD
PMID:30207508
NCBI chr 1:214,608,453...214,630,524
Ensembl chr 1:214,608,704...214,629,938
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Myc
MYC proto-oncogene, bHLH transcription factor
multiple interactions increases expression
EXP ISO
[EGF protein co-treated with DDT] results in increased expression of MYC mRNA DDT results in increased expression of MYC protein fulvestrant inhibits the reaction [DDT results in increased expression of MYC mRNA] DDT results in increased expression of MYC mRNA; DDT results in increased expression of MYC protein
CTD
PMID:12632255 PMID:23684557 PMID:24968063
NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
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Myh11
myosin heavy chain 11
increases expression
EXP
DDT results in increased expression of MYH11 mRNA
CTD
PMID:30207508
NCBI chr10:764,421...859,184
Ensembl chr10:764,421...859,184
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Nav1
neuron navigator 1
increases methylation
EXP
DDT results in increased methylation of NAV1 gene
CTD
PMID:30207508
NCBI chr13:52,260,474...52,515,016
Ensembl chr13:52,267,254...52,514,875
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Nfe2l2
nuclear factor, erythroid 2-like 2
increases expression
ISO
DDT results in increased expression of NFE2L2 mRNA
CTD
PMID:31521043
NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
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Nfkb1
nuclear factor kappa B subunit 1
decreases expression
ISO
DDT results in decreased expression of NFKB1 protein
CTD
PMID:16696175
NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
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Nhsl2
NHS-like 2
increases methylation
EXP
DDT results in increased methylation of NHSL2 gene
CTD
PMID:30207508
NCBI chr X:71,895,202...71,980,019
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Nid1
nidogen 1
increases expression
EXP
DDT results in increased expression of NID1 mRNA
CTD
PMID:30207508
NCBI chr17:90,553,161...90,627,133
Ensembl chr17:90,553,394...90,627,101
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Nipal3
NIPA-like domain containing 3
increases methylation
EXP
DDT results in increased methylation of NIPAL3 gene
CTD
PMID:30207508
NCBI chr 5:153,808,169...153,843,961
Ensembl chr 5:153,807,955...153,840,178
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Nlrc5
NLR family, CARD domain containing 5
increases methylation
EXP
DDT results in increased methylation of NLRC5 gene
CTD
PMID:30207508
NCBI chr19:10,904,381...11,006,202
Ensembl chr19:10,905,542...10,976,396
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Nlrp5
NLR family, pyrin domain containing 5
decreases expression
EXP
DDT results in decreased expression of NLRP5 mRNA
CTD
PMID:30207508
NCBI chr 1:71,452,184...71,490,915
Ensembl chr 1:71,453,798...71,486,790
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Nos2
nitric oxide synthase 2
decreases expression multiple interactions increases expression
EXP ISO
DDT results in decreased expression of NOS2 mRNA [DDT co-treated with o,p'-DDT] results in decreased expression of NOS2 mRNA DDT results in increased expression of NOS2 mRNA DDT metabolite results in decreased expression of NOS2 mRNA; DDT results in decreased expression of NOS2 mRNA
CTD
PMID:11948501 PMID:12007859
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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Notch1
notch receptor 1
increases activity multiple interactions
ISO
DDT results in increased activity of NOTCH1 protein MAP2K6 protein promotes the reaction [DDT results in increased activity of NOTCH1 protein]
CTD
PMID:18791200
NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
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Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression
ISO
DDT results in increased expression of NQO1 mRNA
CTD
PMID:31521043
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions increases activity
ISO
[DDT co-treated with Dieldrin] results in increased activity of NR1I2 protein; DDT binds to and results in increased activity of NR1I2 protein DDT results in increased activity of NR1I2 protein
CTD
PMID:15548381 PMID:16054614 PMID:20686338 PMID:25028461 PMID:25680588
NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
increases expression increases activity multiple interactions
ISO
DDT results in increased expression of NR1I3 mRNA DDT results in increased activity of NR1I3 protein DDT inhibits the reaction [Androstenols results in decreased activity of NR1I3 protein]; DDT promotes the reaction [NR1I3 protein binds to CYP2B10 promoter] DDT binds to and results in increased activity of and results in increased localization of NR1I3 protein mutant form
CTD
PMID:16929008 PMID:19746742 PMID:20686338 PMID:23684557 PMID:28927721
NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
multiple interactions
ISO
DDT inhibits the reaction [Hydrocortisone results in increased activity of NR3C1 protein]
CTD
PMID:26647222
NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
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Nr3c2
nuclear receptor subfamily 3, group C, member 2
multiple interactions
ISO
DDT inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; DDT inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]
CTD
PMID:29149346
NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
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Nrxn1
neurexin 1
increases methylation
EXP
DDT results in increased methylation of NRXN1 gene
CTD
PMID:30207508
NCBI chr 6:13,886,757...15,191,660
Ensembl chr 6:13,886,740...15,191,660
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Nrxn3
neurexin 3
increases methylation
EXP
DDT results in increased methylation of NRXN3 gene
CTD
PMID:30207508
NCBI chr 6:112,133,204...114,069,589
Ensembl chr 6:112,133,204...114,067,564
G
Ntn1
netrin 1
increases methylation
EXP
DDT results in increased methylation of NTN1 gene
CTD
PMID:30207508
NCBI chr10:54,761,925...54,982,072
Ensembl chr10:54,761,871...54,967,585
G
Ntn4
netrin 4
decreases expression
EXP
DDT results in decreased expression of NTN4 mRNA
CTD
PMID:30207508
NCBI chr 7:34,533,543...34,649,330
Ensembl chr 7:34,533,543...34,649,481
G
Ntrk1
neurotrophic receptor tyrosine kinase 1
multiple interactions
ISO
[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK1 mRNA
CTD
PMID:28263720
NCBI chr 2:187,143,568...187,160,373
Ensembl chr 2:187,143,568...187,160,373
G
Ntrk2
neurotrophic receptor tyrosine kinase 2
multiple interactions
ISO
[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK2 mRNA
CTD
PMID:28263720
NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
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Nvl
nuclear VCP-like
increases methylation
EXP
DDT results in increased methylation of NVL gene
CTD
PMID:30207508
NCBI chr13:99,410,026...99,468,783
Ensembl chr13:99,410,026...99,468,778
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Ogfod3
2-oxoglutarate and iron-dependent oxygenase domain containing 3
increases methylation
EXP
DDT results in increased methylation of OGFOD3 gene
CTD
PMID:30207508
NCBI chr10:110,378,533...110,406,377
Ensembl chr10:110,378,534...110,406,377
G
Ogg1
8-oxoguanine DNA glycosylase
multiple interactions increases expression
EXP
[DDT co-treated with Diethylnitrosamine] results in decreased expression of OGG1 mRNA; [DDT co-treated with Diethylnitrosamine] results in increased expression of OGG1 mRNA DDT results in increased expression of OGG1 mRNA
CTD
PMID:11948501 PMID:15885732
NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
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Ogt
O-linked N-acetylglucosamine (GlcNAc) transferase
increases expression increases methylation
ISO EXP
DDT results in increased expression of OGT mRNA DDT results in increased methylation of OGT gene
CTD
PMID:25014179 PMID:30207508
NCBI chr X:71,540,870...71,585,906
Ensembl chr X:71,528,988...71,585,908
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Olr1135
olfactory receptor 1135
decreases methylation
EXP
DDT results in decreased methylation of OLR1135 gene
CTD
PMID:30207508
NCBI chr 8:19,081,540...19,082,478
Ensembl chr 8:19,081,540...19,082,478
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Olr1442
olfactory receptor 1442
increases methylation
EXP
DDT results in increased methylation of OLR1442 gene
CTD
PMID:30207508
NCBI chr10:44,527,468...44,528,382
Ensembl chr10:44,527,468...44,528,382
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Olr1757-ps
olfactory receptor pseudogene 1757
increases methylation
EXP
DDT results in increased methylation of OLR1757-PS gene
CTD
PMID:30207508
NCBI chr 4:33,140,048...33,140,509
G
Ophn1
oligophrenin 1
decreases methylation
EXP
DDT results in decreased methylation of OPHN1 gene
CTD
PMID:30207508
NCBI chr X:68,185,865...68,579,518
Ensembl chr X:68,189,161...68,563,137
G
Pamr1
peptidase domain containing associated with muscle regeneration 1
decreases expression
EXP
DDT results in decreased expression of PAMR1 mRNA
CTD
PMID:30207508
NCBI chr 3:92,403,533...92,502,094
Ensembl chr 3:92,403,582...92,502,089
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Pard3
par-3 family cell polarity regulator
increases methylation
EXP
DDT results in increased methylation of PARD3 gene
CTD
PMID:30207508
NCBI chr19:60,017,746...60,580,628
Ensembl chr19:60,017,746...60,580,651
G
Pcdh20
protocadherin 20
decreases expression
EXP
DDT results in decreased expression of PCDH20 mRNA
CTD
PMID:30207508
NCBI chr15:71,772,777...71,779,033
Ensembl chr15:71,772,777...71,779,033
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Pcdh9
protocadherin 9
decreases expression
EXP
DDT results in decreased expression of PCDH9 mRNA
CTD
PMID:30207508
NCBI chr15:76,787,108...77,738,668
Ensembl chr15:77,733,402...77,736,892
G
Pck1
phosphoenolpyruvate carboxykinase 1
multiple interactions
EXP
DDT inhibits the reaction [Hydrocortisone results in increased expression of PCK1 mRNA]
CTD
PMID:26647222
NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
G
Pclo
piccolo (presynaptic cytomatrix protein)
decreases expression
EXP
DDT results in decreased expression of PCLO mRNA
CTD
PMID:30207508
NCBI chr 4:16,454,904...17,058,921
Ensembl chr 4:16,454,904...17,058,921
G
Pdcd4
programmed cell death 4
increases expression
ISO
DDT results in increased expression of PDCD4 mRNA
CTD
PMID:22403704
NCBI chr 1:274,616,625...274,648,204
Ensembl chr 1:274,625,224...274,648,204
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Pde7b
phosphodiesterase 7B
decreases expression
EXP
DDT results in decreased expression of PDE7B mRNA
CTD
PMID:30207508
NCBI chr 1:15,889,845...16,203,909
Ensembl chr 1:15,893,533...16,203,909
G
Pdgfra
platelet derived growth factor receptor alpha
increases expression
EXP
DDT results in increased expression of PDGFRA mRNA
CTD
PMID:30207508
NCBI chr14:35,527,926...35,581,130
Ensembl chr14:35,527,927...35,581,031
G
Pdgfrb
platelet derived growth factor receptor beta
multiple interactions
ISO
[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of PDGFRB mRNA
CTD
PMID:28263720
NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
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Pdk1
pyruvate dehydrogenase kinase 1
increases expression multiple interactions
ISO
DDT results in increased expression of PDK1 mRNA 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [DDT results in increased expression of PDK1 mRNA]; Acetylcysteine inhibits the reaction [DDT results in increased expression of PDK1 mRNA]; PKM protein alternative form affects the reaction [DDT results in increased expression of PDK1 mRNA]
CTD
PMID:31724279
NCBI chr 3:58,530,870...58,561,494
Ensembl chr 3:58,530,870...58,558,027
G
Pdlim3
PDZ and LIM domain 3
decreases expression
EXP
DDT results in decreased expression of PDLIM3 mRNA
CTD
PMID:30207508
NCBI chr16:49,543,140...49,574,362
Ensembl chr16:49,543,142...49,574,390
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Penk
proenkephalin
decreases expression
EXP
DDT results in decreased expression of PENK mRNA
CTD
PMID:19797855
NCBI chr 5:17,056,412...17,061,762
Ensembl chr 5:17,056,419...17,061,837
G
Pgf
placental growth factor
decreases methylation
EXP
DDT results in decreased methylation of PGF gene
CTD
PMID:30207508
NCBI chr 6:108,994,016...109,004,598
Ensembl chr 6:108,994,018...109,004,598
G
Pgr
progesterone receptor
affects binding increases expression multiple interactions
ISO
DDT binds to PGR protein DDT results in increased expression of PGR mRNA [DDT results in increased activity of ESR1 protein] which results in increased expression of PGR mRNA; DDT inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein]; DDT inhibits the reaction [Progesterone binds to PGR protein]; DDT inhibits the reaction [Progesterone results in increased expression of PGR protein]
CTD
PMID:9607801 PMID:14579009 PMID:15541753 PMID:18262749 PMID:22403704 PMID:26022396
NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
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Phex
phosphate regulating endopeptidase homolog, X-linked
decreases expression
EXP
DDT results in decreased expression of PHEX mRNA
CTD
PMID:30207508
NCBI chr X:40,460,047...40,717,982
Ensembl chr X:40,460,047...40,717,982
G
Phf3
PHD finger protein 3
decreases methylation
EXP
DDT results in decreased methylation of PHF3 gene
CTD
PMID:30207508
NCBI chr 9:37,073,514...37,144,027
Ensembl chr 9:37,073,514...37,144,015
G
Pik3c2a
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
decreases expression
EXP
DDT results in decreased expression of PIK3C2A mRNA
CTD
PMID:30207508
NCBI chr 1:185,210,922...185,326,314
Ensembl chr 1:185,210,922...185,326,314
G
Pkm
pyruvate kinase M1/2
multiple interactions increases expression
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [DDT results in increased expression of and affects the localization of PKM protein alternative form]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [DDT results in increased expression of PKM mRNA alternative form]; Acetylcysteine inhibits the reaction [DDT results in increased expression of and affects the localization of PKM protein alternative form]; Acetylcysteine inhibits the reaction [DDT results in increased expression of PKM mRNA alternative form]; DDT results in increased expression of and affects the localization of PKM protein alternative form; PKM protein alternative form affects the reaction [DDT results in increased expression of LDHA mRNA]; PKM protein alternative form affects the reaction [DDT results in increased expression of PDK1 mRNA]; PKM protein alternative form affects the reaction [DDT results in increased expression of SLC2A1 mRNA]
CTD
PMID:31724279
NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
G
Pkp4
plakophilin 4
increases methylation
EXP
DDT results in increased methylation of PKP4 gene
CTD
PMID:30207508
NCBI chr 3:45,211,097...45,414,524
Ensembl chr 3:45,277,348...45,414,613
G
Plat
plasminogen activator, tissue type
decreases expression
ISO
DDT results in decreased expression of PLAT mRNA
CTD
PMID:25014179
NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
G
Pld4
phospholipase D family, member 4
increases methylation
EXP
DDT results in increased methylation of PLD4 gene
CTD
PMID:30207508
NCBI chr 6:137,323,713...137,331,231
Ensembl chr 6:137,323,713...137,331,231
G
Pls3
plastin 3
decreases expression
EXP
DDT results in decreased expression of PLS3 mRNA
CTD
PMID:30207508
NCBI chr X:119,030,311...119,124,268
Ensembl chr X:119,030,419...119,124,250
G
Plxdc2
plexin domain containing 2
decreases expression
EXP
DDT results in decreased expression of PLXDC2 mRNA
CTD
PMID:30207508
NCBI chr17:83,221,795...83,619,291
Ensembl chr17:83,221,827...83,610,272
G
Plxnd1
plexin D1
multiple interactions
ISO
[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of PLXND1 mRNA
CTD
PMID:28263720
NCBI chr 4:147,854,309...147,894,170
Ensembl chr 4:147,854,309...147,893,992
G
Pnpla8
patatin-like phospholipase domain containing 8
decreases expression
EXP
DDT results in decreased expression of PNPLA8 mRNA
CTD
PMID:30207508
NCBI chr 6:64,224,870...64,288,465
Ensembl chr 6:64,224,861...64,286,785
G
Podxl
podocalyxin-like
decreases expression
ISO
DDT results in decreased expression of PODXL mRNA
CTD
PMID:25014179
NCBI chr 4:58,829,049...58,893,353
Ensembl chr 4:58,829,060...58,893,170
G
Polq
DNA polymerase theta
decreases methylation
EXP
DDT results in decreased methylation of POLQ gene
CTD
PMID:30207508
NCBI chr11:66,585,860...66,695,369
Ensembl chr11:66,585,881...66,695,353
G
Pomc
proopiomelanocortin
multiple interactions
ISO
[Hexachlorocyclohexane co-treated with DDT] results in increased expression of POMC
CTD
PMID:16329587
NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
G
Potem
POTE ankyrin domain family member M
increases methylation
EXP
DDT results in increased methylation of POTEM gene
CTD
PMID:30207508
NCBI chr16:21,947,702...22,118,777
Ensembl chr16:21,955,168...22,116,834
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions increases expression
ISO
DDT results in increased activity of and results in increased localization of PPARG protein DDT results in increased expression of PPARG mRNA
CTD
PMID:11911853 PMID:25014179
NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
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Ppargc1a
PPARG coactivator 1 alpha
multiple interactions
ISO
DDT promotes the reaction [PPARGC1A protein binds to CYP2B10 promoter]
CTD
PMID:23684557
NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
G
Ppp2r2b
protein phosphatase 2, regulatory subunit B, beta
increases methylation
EXP
DDT results in increased methylation of PPP2R2B gene
CTD
PMID:30207508
NCBI chr18:36,985,709...37,421,383
Ensembl chr18:36,985,714...37,245,809
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Prex2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
decreases expression
EXP
DDT results in decreased expression of PREX2 mRNA
CTD
PMID:30207508
NCBI chr 5:7,622,668...7,941,715
Ensembl chr 5:7,627,771...7,941,822
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Prkaa2
protein kinase AMP-activated catalytic subunit alpha 2
decreases expression
EXP
DDT results in decreased expression of PRKAA2 mRNA
CTD
PMID:30207508
NCBI chr 5:124,568,845...124,642,569
Ensembl chr 5:124,574,079...124,642,569
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Pros1
protein S
decreases expression
EXP
DDT results in decreased expression of PROS1 mRNA
CTD
PMID:30207508
NCBI chr 7:1,206,648...1,288,140
Ensembl chr 7:1,206,648...1,288,134
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Ptgs1
prostaglandin-endoperoxide synthase 1
decreases expression
ISO
DDT results in decreased expression of PTGS1 mRNA
CTD
PMID:25014179
NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions increases expression
ISO
aurapten inhibits the reaction [DDT results in increased expression of PTGS2 mRNA]; zerumbone inhibits the reaction [DDT results in increased expression of PTGS2 mRNA]
CTD
PMID:20865247
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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Ptprm
protein tyrosine phosphatase, receptor type, M
decreases methylation
EXP
DDT results in decreased methylation of PTPRM gene
CTD
PMID:30207508
NCBI chr 9:114,846,095...115,555,261
Ensembl chr 9:114,846,095...115,555,261
G
Qser1
glutamine and serine rich 1
decreases expression
EXP
DDT results in decreased expression of QSER1 mRNA
CTD
PMID:30207508
NCBI chr 3:94,702,635...94,767,364
Ensembl chr 3:94,702,663...94,767,239
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Rab4b
RAB4B, member RAS oncogene family
increases methylation
EXP
DDT results in increased methylation of RAB4B gene
CTD
PMID:30207508
NCBI chr 1:83,979,298...83,990,680
Ensembl chr 1:83,979,298...83,990,588
G
Rabggtb
Rab geranylgeranyltransferase subunit beta
increases expression
ISO
DDT results in increased expression of RABGGTB mRNA
CTD
PMID:25014179
NCBI chr 2:260,110,309...260,115,574
Ensembl chr 2:260,110,309...260,115,577
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Rack1
receptor for activated C kinase 1
decreases expression
ISO
DDT results in decreased expression of RACK1 mRNA; DDT results in decreased expression of RACK1 protein
CTD
PMID:28412309
NCBI chr10:34,149,717...34,155,198
Ensembl chr10:34,149,717...34,155,198 Ensembl chr12:34,149,717...34,155,198
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Ranbp2
RAN binding protein 2
decreases expression
EXP
DDT results in decreased expression of RANBP2 mRNA
CTD
PMID:30207508
NCBI chr20:28,027,054...28,076,664 NCBI chr20:28,365,538...28,375,676
Ensembl chr20:28,027,054...28,076,664 Ensembl chr20:28,027,054...28,076,664
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Rasef
RAS and EF hand domain containing
decreases expression
EXP
DDT results in decreased expression of RASEF mRNA
CTD
PMID:30207508
NCBI chr 5:90,419,044...90,488,882
Ensembl chr 5:90,419,020...90,488,896
G
Rb1
RB transcriptional corepressor 1
increases phosphorylation
ISO
DDT results in increased phosphorylation of RB1 protein
CTD
PMID:9049186 PMID:23684557
NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
G
Rb1cc1
RB1-inducible coiled-coil 1
decreases expression
EXP
DDT results in decreased expression of RB1CC1 mRNA
CTD
PMID:30207508
NCBI chr 5:13,033,918...13,097,369
Ensembl chr 5:13,033,918...13,097,341
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Rcan2
regulator of calcineurin 2
decreases expression
EXP
DDT results in decreased expression of RCAN2 mRNA
CTD
PMID:30207508
NCBI chr 9:19,518,568...19,749,145
Ensembl chr 9:19,518,558...19,749,145
G
Rcn2
reticulocalbin 2
decreases expression
EXP
DDT results in decreased expression of RCN2 mRNA
CTD
PMID:30207508
NCBI chr 8:60,709,851...60,726,938
Ensembl chr 8:60,709,851...60,726,936
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Ret
ret proto-oncogene
multiple interactions
ISO
[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of RET mRNA
CTD
PMID:28263720
NCBI chr 4:150,202,170...150,249,196
Ensembl chr 4:150,202,058...150,244,372
G
Rftn1
raftlin lipid raft linker 1
decreases methylation
EXP
DDT results in decreased methylation of RFTN1 gene
CTD
PMID:30207508
NCBI chr 9:12,740,885...12,942,358
Ensembl chr 9:12,740,885...12,942,358
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RGD1309104
similar to RIKEN cDNA 1700025G04 gene
increases methylation
EXP
DDT results in increased methylation of RGD1309104 gene
CTD
PMID:30207508
NCBI chr13:69,265,649...69,434,447
Ensembl chr13:69,265,649...69,385,074
G
Ripk4
receptor-interacting serine-threonine kinase 4
increases methylation
EXP
DDT results in increased methylation of RIPK4 gene
CTD
PMID:30207508
NCBI chr11:38,251,991...38,274,234
Ensembl chr11:38,251,955...38,274,217
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Rlf
RLF zinc finger
decreases expression
EXP
DDT results in decreased expression of RLF mRNA
CTD
PMID:30207508
NCBI chr 5:140,107,144...140,162,698
Ensembl chr 5:140,107,275...140,162,642
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Rnf150
ring finger protein 150
increases methylation
EXP
DDT results in increased methylation of RNF150 gene
CTD
PMID:30207508
NCBI chr19:24,044,210...24,264,508
Ensembl chr19:24,044,103...24,265,444
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Rnf152
ring finger protein 152
increases methylation
EXP
DDT results in increased methylation of RNF152 gene
CTD
PMID:30207508
NCBI chr13:25,183,295...25,262,785
Ensembl chr13:25,186,106...25,262,469
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Rnf181
ring finger protein 181
decreases expression
ISO
DDT results in decreased expression of RNF181 mRNA
CTD
PMID:25014179
NCBI chr 4:100,222,087...100,228,809
Ensembl chr 4:100,222,106...100,228,809
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Rock2
Rho-associated coiled-coil containing protein kinase 2
decreases expression
EXP
DDT results in decreased expression of ROCK2 mRNA
CTD
PMID:30207508
NCBI chr 6:42,180,864...42,289,910
Ensembl chr 6:42,180,894...42,289,908
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Rpl4
ribosomal protein L4
increases expression
ISO
DDT results in increased expression of RPL4 mRNA
CTD
PMID:25014179
NCBI chr 8:69,121,682...69,126,805
Ensembl chr 8:69,121,682...69,126,805
G
Rsad2
radical S-adenosyl methionine domain containing 2
decreases expression
ISO
DDT results in decreased expression of RSAD2 mRNA
CTD
PMID:25014179
NCBI chr 6:45,655,947...45,669,083
Ensembl chr 6:45,655,954...45,669,148
G
Rsf1
remodeling and spacing factor 1
decreases expression
EXP
DDT results in decreased expression of RSF1 mRNA
CTD
PMID:30207508
NCBI chr 1:162,549,222...162,671,962
Ensembl chr 1:162,549,420...162,662,170
G
RT1-Ba
RT1 class II, locus Ba
decreases methylation
EXP
DDT results in decreased methylation of RT1-BA gene
CTD
PMID:30207508
NCBI chr20:4,066,133...4,070,726
Ensembl chr20:4,066,132...4,070,721
G
RT1-Bb
RT1 class II, locus Bb
decreases methylation
EXP
DDT results in decreased methylation of RT1-BB gene
CTD
PMID:30207508
NCBI chr20:4,043,726...4,049,367
Ensembl chr20:4,039,413...4,049,711
G
Runx2
RUNX family transcription factor 2
increases expression
ISO
DDT results in increased expression of RUNX2 mRNA
CTD
PMID:25014179
NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
G
Rxrb
retinoid X receptor beta
increases activity
ISO
DDT analog results in increased activity of RXRB protein
CTD
PMID:18207673
NCBI chr20:3,822,673...3,829,138
Ensembl chr20:3,823,042...3,829,140
G
Ryr1
ryanodine receptor 1
affects activity
ISO
DDT affects the activity of RYR1 protein
CTD
PMID:31127943
NCBI chr 1:87,959,596...88,066,252
Ensembl chr 1:87,959,712...88,066,101
G
S1pr1
sphingosine-1-phosphate receptor 1
decreases expression
EXP
DDT results in decreased expression of S1PR1 mRNA
CTD
PMID:30207508
NCBI chr 2:218,654,406...218,658,761
Ensembl chr 2:218,654,554...218,658,761
G
Sacs
sacsin molecular chaperone
decreases expression
EXP
DDT results in decreased expression of SACS mRNA
CTD
PMID:30207508
NCBI chr15:41,448,078...41,530,412
Ensembl chr15:41,448,064...41,530,398
G
Sarnp
SAP domain containing ribonucleoprotein
decreases expression
EXP
DDT results in decreased expression of SARNP mRNA
CTD
PMID:30207508
NCBI chr 7:3,246,220...3,300,467
Ensembl chr 7:3,246,220...3,300,455
G
Scarb1
scavenger receptor class B, member 1
increases expression
EXP
DDT results in increased expression of SCARB1 mRNA
CTD
PMID:30207508
NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
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Selenop
selenoprotein P
increases expression
EXP
DDT results in increased expression of SELENOP mRNA
CTD
PMID:30207508
NCBI chr 2:53,105,912...53,116,198
Ensembl chr 2:53,109,684...53,114,858
G
Sema4f
ssemaphorin 4F
increases methylation
EXP
DDT results in increased methylation of SEMA4F gene
CTD
PMID:30207508
NCBI chr 4:113,738,225...113,764,532
Ensembl chr 4:113,738,226...113,764,532
G
Sema5a
semaphorin 5A
decreases expression
EXP
DDT results in decreased expression of SEMA5A mRNA
CTD
PMID:30207508
NCBI chr 2:85,377,318...85,808,970
Ensembl chr 2:85,377,318...85,808,970
G
Serpinb5
serpin family B member 5
multiple interactions
ISO
[DDT results in increased activity of ESR1 protein] which results in increased expression of SERPINB5 mRNA
CTD
PMID:22403704
NCBI chr13:26,903,052...26,923,250
Ensembl chr13:26,903,052...26,923,250
G
Sesn3
sestrin 3
decreases expression
EXP
DDT results in decreased expression of SESN3 mRNA
CTD
PMID:30207508
NCBI chr 8:12,823,060...12,878,749
Ensembl chr 8:12,823,155...12,872,705
G
Setd2
SET domain containing 2, histone lysine methyltransferase
decreases expression
EXP
DDT results in decreased expression of SETD2 mRNA
CTD
PMID:30207508
NCBI chr 8:118,802,478...118,888,224
Ensembl chr 8:118,803,075...118,888,224
G
Setx
senataxin
decreases expression
EXP
DDT results in decreased expression of SETX mRNA
CTD
PMID:30207508
NCBI chr 3:7,680,430...7,731,815
Ensembl chr 3:7,686,503...7,730,539
G
Sgip1
SH3GL interacting endocytic adaptor 1
increases methylation
EXP
DDT results in increased methylation of SGIP1 gene
CTD
PMID:30207508
NCBI chr 5:122,300,415...122,498,478
Ensembl chr 5:122,390,522...122,491,203
G
Shbg
sex hormone binding globulin
multiple interactions
EXP
DDT analog inhibits the reaction [Dihydrotestosterone binds to SHBG protein]; DDT inhibits the reaction [Dihydrotestosterone binds to SHBG protein]
CTD
PMID:9171990
NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
G
Shc4
SHC adaptor protein 4
increases methylation
EXP
DDT results in increased methylation of SHC4 gene
CTD
PMID:30207508
NCBI chr 3:117,897,738...117,990,289
Ensembl chr 3:117,897,738...117,990,289
G
Shcbp1
SHC binding and spindle associated 1
decreases expression
ISO
DDT results in decreased expression of SHCBP1 mRNA
CTD
PMID:25014179
NCBI chr16:90,613,826...90,642,683
Ensembl chr16:90,613,870...90,641,420
G
Slc10a1
solute carrier family 10 member 1
decreases expression
ISO
DDT results in decreased expression of SLC10A1 mRNA
CTD
PMID:24464585
NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
G
Slc12a2
solute carrier family 12 member 2
multiple interactions
ISO
[o,p'-DDT co-treated with DDT] results in increased expression of SLC12A2 mRNA
CTD
PMID:27325568
NCBI chr18:52,917,124...52,985,281
Ensembl chr18:52,917,124...52,985,261
G
Slc18a2
solute carrier family 18 member A2
multiple interactions
ISO
DDT inhibits the reaction [SLC18A2 protein results in increased uptake of Dopamine]
CTD
PMID:18533268
NCBI chr 1:280,397,831...280,457,968
Ensembl chr 1:280,423,079...280,457,148
G
Slc2a1
solute carrier family 2 member 1
multiple interactions increases expression
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [DDT results in increased expression of SLC2A1 mRNA]; Acetylcysteine inhibits the reaction [DDT results in increased expression of SLC2A1 mRNA]; PKM protein alternative form affects the reaction [DDT results in increased expression of SLC2A1 mRNA]
CTD
PMID:31724279
NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
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Slc2a4
solute carrier family 2 member 4
increases expression decreases expression
ISO EXP
DDT results in increased expression of SLC2A4 mRNA DDT results in decreased expression of SLC2A4 protein
CTD
PMID:25014179 PMID:31923579
NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
G
Slc6a3
solute carrier family 6 member 3
multiple interactions
ISO
DDT inhibits the reaction [DAT protein results in increased uptake of Dopamine]
CTD
PMID:18533268
NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
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Slc7a11
solute carrier family 7 member 11
increases expression
ISO
DDT results in increased expression of SLC7A11 mRNA
CTD
PMID:26198647
NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
G
Slc8a1
solute carrier family 8 member A1
multiple interactions
ISO
[o,p'-DDT co-treated with DDT] results in increased expression of SLC8A1 mRNA
CTD
PMID:27325568
NCBI chr 6:4,244,076...4,564,262
Ensembl chr 6:4,258,991...4,520,604
G
Slc9a1
solute carrier family 9 member A1
multiple interactions
ISO
[o,p'-DDT co-treated with DDT] results in increased expression of SLC9A1 mRNA
CTD
PMID:27325568
NCBI chr 5:151,573,122...151,626,360
Ensembl chr 5:151,573,092...151,627,316
G
Slc9a2
solute carrier family 9 member A2
multiple interactions
ISO
[o,p'-DDT co-treated with DDT] results in increased expression of SLC9A2 mRNA
CTD
PMID:27325568
NCBI chr 9:47,386,581...47,491,813
Ensembl chr 9:47,386,626...47,491,907
G
Slc9a3
solute carrier family 9 member A3
multiple interactions
ISO
[o,p'-DDT co-treated with DDT] results in increased expression of SLC9A3 mRNA
CTD
PMID:27325568
NCBI chr 1:31,731,652...31,777,144
Ensembl chr 1:31,734,327...31,777,070
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Snhg11
small nucleolar RNA host gene 11
increases expression
ISO
DDT results in increased expression of SNHG11 mRNA
CTD
PMID:25014179
NCBI chr 3:154,862,717...154,870,691
Ensembl chr 3:154,863,072...154,869,460
G
Sod1
superoxide dismutase 1
multiple interactions
EXP
[Polychlorinated Biphenyls co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Chlordan co-treated with nonachlor] inhibits the reaction [Fish Oils results in increased expression of SOD1 mRNA]
CTD
PMID:28659405
NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
G
Sod3
superoxide dismutase 3
increases expression
EXP
DDT results in increased expression of SOD3 mRNA
CTD
PMID:30207508
NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
G
Sos1
SOS Ras/Rac guanine nucleotide exchange factor 1
multiple interactions
ISO
DDT promotes the reaction [GRB2 protein binds to SOS1 protein]
CTD
PMID:9070211
NCBI chr 6:3,105,443...3,182,977
Ensembl chr 6:3,104,861...3,182,996
G
Sparc
secreted protein acidic and cysteine rich
increases expression
ISO
DDT results in increased expression of SPARC mRNA
CTD
PMID:25014179
NCBI chr10:40,742,390...40,764,232
Ensembl chr10:40,742,400...40,764,185
G
Spcs3
signal peptidase complex subunit 3
decreases expression
EXP
DDT results in decreased expression of SPCS3 mRNA
CTD
PMID:30207508
NCBI chr16:40,050,862...40,056,296
Ensembl chr16:40,050,734...40,058,822
G
Spp1
secreted phosphoprotein 1
increases expression decreases expression
ISO EXP
DDT results in increased expression of SPP1 mRNA DDT results in decreased expression of SPP1 mRNA
CTD
PMID:25014179 PMID:30207508
NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
G
Sqstm1
sequestosome 1
increases expression
ISO
DDT results in increased expression of SQSTM1 mRNA
CTD
PMID:26198647
NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
G
Srebf2
sterol regulatory element binding transcription factor 2
increases methylation
EXP
DDT results in increased methylation of SREBF2 gene
CTD
PMID:30207508
NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603
G
Srxn1
sulfiredoxin 1
increases expression
ISO
DDT results in increased expression of SRXN1 mRNA
CTD
PMID:26198647
NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
G
Sspn
sarcospan
decreases expression
EXP
DDT results in decreased expression of SSPN mRNA
CTD
PMID:30207508
NCBI chr 4:180,291,389...180,325,799
Ensembl chr 4:180,291,389...180,324,408
G
Sst
somatostatin
decreases expression
EXP
DDT results in decreased expression of SST mRNA
CTD
PMID:19797855
NCBI chr11:80,358,172...80,359,449
Ensembl chr11:80,358,211...80,359,444
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ST7
suppression of tumorigenicity 7
increases methylation
EXP
DDT results in increased methylation of ST7 gene
CTD
PMID:30207508
NCBI chr 4:45,000,223...45,247,793
Ensembl chr 4:45,000,973...45,247,790
G
St8sia1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
increases methylation
EXP
DDT results in increased methylation of ST8SIA1 gene
CTD
PMID:30207508
NCBI chr 4:177,065,266...177,195,942
Ensembl chr 4:177,065,168...177,196,180
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Stat1
signal transducer and activator of transcription 1
increases phosphorylation
ISO
DDT results in increased phosphorylation of STAT1 protein
CTD
PMID:9070211
NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
G
Stat3
signal transducer and activator of transcription 3
multiple interactions affects localization
ISO
Acetylcysteine inhibits the reaction [DDT results in increased phosphorylation of and results in increased expression of STAT3 protein]; DDT results in increased phosphorylation of and results in increased expression of STAT3 protein; INCB018424 inhibits the reaction [DDT results in increased phosphorylation of STAT3 protein]; WP1066 inhibits the reaction [DDT results in increased phosphorylation of STAT3 protein] DDT affects the localization of STAT3 protein
CTD
PMID:24820114
NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
G
Stc1
stanniocalcin 1
decreases expression
EXP
DDT results in decreased expression of STC1 mRNA
CTD
PMID:30207508
NCBI chr15:50,891,137...50,901,791
Ensembl chr15:50,891,127...50,903,162
G
Stk11ip
serine/threonine kinase 11 interacting protein
increases methylation
EXP
DDT results in increased methylation of STK11IP gene
CTD
PMID:30207508
NCBI chr 9:82,718,343...82,733,894
Ensembl chr 9:82,718,709...82,734,393
G
Stpg1
sperm-tail PG-rich repeat containing 1
increases methylation
EXP
DDT results in increased methylation of STPG1 gene
CTD
PMID:30207508
NCBI chr 5:153,834,263...153,888,510
Ensembl chr 5:153,835,821...153,888,506
G
Stx8
syntaxin 8
increases methylation
EXP
DDT results in increased methylation of STX8 gene
CTD
PMID:30207508
NCBI chr10:54,512,922...54,753,302
Ensembl chr10:54,512,983...54,753,302
G
Stxbp6
syntaxin binding protein 6
decreases expression
EXP
DDT results in decreased expression of STXBP6 mRNA
CTD
PMID:30207508
NCBI chr 6:65,086,483...65,319,527
Ensembl chr 6:65,089,318...65,319,527
G
Syne2
spectrin repeat containing nuclear envelope protein 2
decreases expression
EXP
DDT results in decreased expression of SYNE2 mRNA
CTD
PMID:30207508
NCBI chr 6:98,884,269...99,153,551
G
Taf1d
TATA-box binding protein associated factor, RNA polymerase I subunit D
increases expression
ISO
DDT results in increased expression of TAF1D mRNA
CTD
PMID:25014179
NCBI chr 8:13,861,242...13,871,508
Ensembl chr 8:13,861,459...13,871,354
G
Taf9b
TATA-box binding protein associated factor 9b
increases methylation
EXP
DDT results in increased methylation of TAF9B gene
CTD
PMID:30207508
NCBI chr X:77,281,234...77,295,238
Ensembl chr X:77,281,210...77,295,426
G
Tax1bp1
Tax1 binding protein 1
decreases expression
EXP
DDT results in decreased expression of TAX1BP1 mRNA
CTD
PMID:30207508
NCBI chr 4:82,776,720...82,832,586
Ensembl chr 4:82,776,746...82,833,773
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Tbx21
T-box transcription factor 21
decreases methylation
EXP
DDT results in decreased methylation of TBX21 gene
CTD
PMID:30207508
NCBI chr10:85,032,799...85,049,331
Ensembl chr10:85,032,799...85,049,331
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Tdrd7
tudor domain containing 7
decreases expression
EXP
DDT results in decreased expression of TDRD7 mRNA
CTD
PMID:30207508
NCBI chr 5:61,557,909...61,631,719
Ensembl chr 5:61,564,864...61,631,710
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Tet1
tet methylcytosine dioxygenase 1
decreases expression
EXP
DDT results in decreased expression of TET1 mRNA
CTD
PMID:30207508
NCBI chr20:27,359,122...27,438,039
Ensembl chr20:27,366,213...27,437,427
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Tff1
trefoil factor 1
multiple interactions
ISO
[DDT results in increased activity of ESR1 protein] which results in increased expression of TFF1 mRNA
CTD
PMID:22403704
NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
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Tgfb1
transforming growth factor, beta 1
multiple interactions
EXP
DDT inhibits the reaction [TGFB1 protein results in increased activity of CASP3 protein]
CTD
PMID:10200566
NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
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Tgfb3
transforming growth factor, beta 3
increases expression
EXP
DDT results in increased expression of TGFB3 mRNA
CTD
PMID:29477483
NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533
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Thsd7a
thrombospondin type 1 domain containing 7A
decreases expression
EXP
DDT results in decreased expression of THSD7A mRNA
CTD
PMID:30207508
NCBI chr 4:38,658,512...39,103,411
Ensembl chr 4:38,664,066...39,102,807
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Tie1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
decreases expression
ISO
DDT results in decreased expression of TIE1 mRNA
CTD
PMID:25014179
NCBI chr 5:137,294,544...137,321,116
Ensembl chr 5:137,294,544...137,321,121
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Tmem107
transmembrane protein 107
increases expression
ISO
DDT results in increased expression of TMEM107 mRNA
CTD
PMID:25014179
NCBI chr10:55,653,694...55,656,270
Ensembl chr10:55,653,946...55,656,270
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Tmem131l
transmembrane 131 like
increases methylation
EXP
DDT results in increased methylation of TMEM131L gene
CTD
PMID:30207508
NCBI chr 2:182,897,332...183,031,273
Ensembl chr 2:182,897,830...183,031,214
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Tmem245
transmembrane protein 245
decreases expression
EXP
DDT results in decreased expression of TMEM245 mRNA
CTD
PMID:30207508
NCBI chr 5:73,909,032...73,986,602
Ensembl chr 5:73,918,747...73,986,373
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Tmem47
transmembrane protein 47
decreases expression
EXP
DDT results in decreased expression of TMEM47 mRNA
CTD
PMID:30207508
NCBI chr X:48,779,110...48,805,644
Ensembl chr X:48,779,110...48,805,644
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Tmx3
thioredoxin-related transmembrane protein 3
decreases expression
EXP
DDT results in decreased expression of TMX3 mRNA
CTD
PMID:30207508
NCBI chr18:87,580,227...87,613,481
Ensembl chr18:87,580,424...87,610,390
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Tnf
tumor necrosis factor
multiple interactions increases expression decreases expression
ISO
13-hydroxy-10-oxo-11-octadecenoic acid inhibits the reaction [DDT results in increased expression of TNF mRNA]; DDT inhibits the reaction [endotoxin, Escherichia coli results in increased expression of TNF protein]; SB 203580 inhibits the reaction [DDT results in increased expression of TNF mRNA] [DDT co-treated with o,p'-DDT] results in decreased expression of TNF mRNA DDT metabolite results in decreased expression of TNF mRNA; DDT results in decreased expression of TNF mRNA
CTD
PMID:12007859 PMID:15603917 PMID:20865247 PMID:28412309 PMID:31521043
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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Tnfrsf11b
TNF receptor superfamily member 11B
decreases expression
EXP
DDT results in decreased expression of TNFRSF11B mRNA
CTD
PMID:30207508
NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
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Tnfrsf1a
TNF receptor superfamily member 1A
decreases expression increases expression
EXP
DDT results in decreased expression of TNFRSF1A mRNA DDT results in increased expression of TNFRSF1A mRNA
CTD
PMID:11948501
NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
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Tp53
tumor protein p53
multiple interactions increases methylation decreases expression
ISO EXP
DDT inhibits the reaction [TRP53 protein binds to CDKN1A promoter] DDT results in increased methylation of TP53 promoter DDT results in decreased expression of TP53 mRNA; DDT results in decreased expression of TP53 protein DDT results in decreased expression of TRP53 protein
CTD
PMID:23684557 PMID:25410620
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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Tp53bp2
tumor protein p53 binding protein, 2
increases methylation
EXP
DDT results in increased methylation of TP53BP2 gene
CTD
PMID:30207508
NCBI chr13:100,817,206...100,873,837
Ensembl chr13:100,817,359...100,873,890
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Tp53inp1
tumor protein p53 inducible nuclear protein 1
decreases expression
EXP
DDT results in decreased expression of TP53INP1 mRNA; DDT results in decreased expression of TP53INP1 protein
CTD
PMID:30207508 PMID:30421125
NCBI chr 5:24,402,895...24,419,651
Ensembl chr 5:24,410,863...24,416,888
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Tpm2
tropomyosin 2
increases expression
EXP
DDT results in increased expression of TPM2 mRNA
CTD
PMID:30207508
NCBI chr 5:59,016,616...59,025,971
Ensembl chr 5:59,016,622...59,025,631
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Tpr
translocated promoter region, nuclear basket protein
decreases expression
EXP
DDT results in decreased expression of TPR mRNA
CTD
PMID:30207508
NCBI chr13:67,611,685...67,672,833
Ensembl chr13:67,611,708...67,672,827
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Traf2
Tnf receptor-associated factor 2
decreases methylation
EXP
DDT results in decreased methylation of TRAF2 gene
CTD
PMID:30207508
NCBI chr 3:2,746,061...2,770,690
Ensembl chr 3:2,746,075...2,770,620
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Trdmt1
tRNA aspartic acid methyltransferase 1
increases methylation
EXP
DDT results in increased methylation of TRDMT1 gene
CTD
PMID:30207508
NCBI chr17:80,824,652...80,859,585
Ensembl chr17:80,826,846...80,860,195
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Trip11
thyroid hormone receptor interactor 11
decreases expression
EXP
DDT results in decreased expression of TRIP11 mRNA
CTD
PMID:30207508
NCBI chr 6:125,741,520...125,812,926
Ensembl chr 6:125,742,796...125,812,517
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Tsc22d3
TSC22 domain family, member 3
multiple interactions
ISO
DDT inhibits the reaction [Hydrocortisone results in increased expression of TSC22D3 mRNA]
CTD
PMID:26647222
NCBI chr X:111,884,285...111,944,693
Ensembl chr X:111,884,295...111,887,906
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Tshr
thyroid stimulating hormone receptor
decreases localization decreases activity multiple interactions
ISO
DDT results in decreased localization of TSHR protein DDT results in decreased activity of TSHR protein DDT binds to and results in decreased activity of TSHR protein
CTD
PMID:14759065 PMID:17062616 PMID:19214582
NCBI chr 6:115,170,290...115,306,871
Ensembl chr 6:115,170,865...115,306,871
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Tspan14
tetraspanin 14
increases methylation
EXP
DDT results in increased methylation of TSPAN14 gene
CTD
PMID:30207508
NCBI chr16:17,538,855...17,595,960
Ensembl chr16:17,538,855...17,595,960
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Ttr
transthyretin
decreases expression
EXP
DDT results in decreased expression of TTR mRNA
CTD
PMID:19797855
NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177
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Tuba3b
tubulin, alpha 3B
increases methylation
EXP
DDT results in increased methylation of TUBA3B gene
CTD
PMID:30207508
NCBI chr 4:179,905,154...179,910,703
Ensembl chr 4:179,905,116...179,910,704
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Tyms
thymidylate synthetase
decreases expression
ISO
DDT results in decreased expression of TYMS mRNA
CTD
PMID:25014179
NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
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Uchl3
ubiquitin C-terminal hydrolase L3
increases expression
EXP
DDT results in increased expression of UCHL3 mRNA
CTD
PMID:30207508
NCBI chr15:86,153,624...86,198,127
Ensembl chr15:86,153,628...86,198,127
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Ugt1a6
UDP glucuronosyltransferase family 1 member A6
decreases expression
ISO
DDT results in decreased expression of UGT1A6 mRNA
CTD
PMID:31521043
NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
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Usp25
ubiquitin specific peptidase 25
decreases methylation
EXP
DDT results in decreased methylation of USP25 gene
CTD
PMID:30207508
NCBI chr11:15,436,080...15,558,646
Ensembl chr11:15,436,269...15,558,646
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Vegfa
vascular endothelial growth factor A
multiple interactions decreases expression increases expression
ISO
13-hydroxy-10-oxo-11-octadecenoic acid inhibits the reaction [DDT results in increased expression of VEGFA mRNA]; aurapten inhibits the reaction [DDT results in increased expression of VEGFA mRNA]; zerumbone inhibits the reaction [DDT results in increased expression of VEGFA mRNA] DDT results in decreased expression of VEGFA mRNA
CTD
PMID:20865247 PMID:31521043
NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
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Vim
vimentin
increases expression
ISO
DDT results in increased expression of VIM mRNA; DDT results in increased expression of VIM protein
CTD
PMID:22902829
NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
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Vmp1
vacuole membrane protein 1
increases expression
ISO
DDT results in increased expression of VMP1 mRNA
CTD
PMID:25014179
NCBI chr10:73,901,988...74,001,900
Ensembl chr10:73,902,837...74,001,895
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Vom2r-ps142
vomeronasal 2 receptor, pseudogene 142
decreases methylation
EXP
DDT results in decreased methylation of VOM2R-PS142 gene
CTD
PMID:30207508
NCBI chr16:64,920,258...64,925,312
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Vrk2
VRK serine/threonine kinase 2
decreases methylation
EXP
DDT results in decreased methylation of VRK2 gene
CTD
PMID:30207508
NCBI chr14:110,739,835...110,883,836
Ensembl chr14:110,739,226...110,883,803
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Vti1a
vesicle transport through interaction with t-SNAREs 1A
increases methylation
EXP
DDT results in increased methylation of VTI1A gene
CTD
PMID:30207508
NCBI chr 1:276,310,072...276,508,635
Ensembl chr 1:276,309,927...276,490,602
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Vwa5a
von Willebrand factor A domain containing 5A
increases expression
EXP
DDT results in increased expression of VWA5A mRNA
CTD
PMID:30207508
NCBI chr 8:42,442,932...42,476,417
Ensembl chr 8:42,443,442...42,466,907 Ensembl chr 3:42,443,442...42,466,907
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Wfikkn2
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
decreases expression
EXP
DDT results in decreased expression of WFIKKN2 mRNA
CTD
PMID:30207508
NCBI chr10:81,936,156...81,943,142
Ensembl chr10:81,936,444...81,942,188
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Wsb1
WD repeat and SOCS box-containing 1
increases expression
ISO
DDT results in increased expression of WSB1 mRNA
CTD
PMID:25014179
NCBI chr10:66,586,905...66,602,984
Ensembl chr10:66,586,924...66,602,987
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Xdh
xanthine dehydrogenase
decreases expression
EXP
DDT results in decreased expression of XDH mRNA
CTD
PMID:30207508
NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
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Zbtb20
zinc finger and BTB domain containing 20
decreases expression
EXP
DDT results in decreased expression of ZBTB20 mRNA
CTD
PMID:30207508
NCBI chr11:62,014,925...62,561,113
Ensembl chr11:62,014,925...62,451,184
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Zc3h18
zinc finger CCCH-type containing 18
increases methylation
EXP
DDT results in increased methylation of ZC3H18 gene
CTD
PMID:30207508
NCBI chr19:55,197,348...55,241,800
Ensembl chr19:55,197,704...55,241,851
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Zdhhc20
zinc finger DHHC-type palmitoyltransferase 20
decreases expression
EXP
DDT results in decreased expression of ZDHHC20 mRNA
CTD
PMID:30207508
NCBI chr15:38,108,886...38,165,765
Ensembl chr15:38,109,301...38,165,746
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Zfp523
zinc finger protein 523
increases methylation
EXP
DDT results in increased methylation of ZFP523 gene
CTD
PMID:30207508
NCBI chr20:7,750,786...7,786,020
Ensembl chr20:7,762,327...7,786,049
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Zfp608
zinc finger protein 608
decreases expression
EXP
DDT results in decreased expression of ZFP608 mRNA
CTD
PMID:30207508
NCBI chr18:49,829,650...49,937,522
Ensembl chr18:49,829,650...49,937,522
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Zfp704
zinc finger protein 704
decreases expression
EXP
DDT results in decreased expression of ZFP704 mRNA
CTD
PMID:30207508
NCBI chr 2:94,377,059...94,559,838
Ensembl chr 2:94,377,072...94,551,529
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Zfpm2
zinc finger protein, multitype 2
increases methylation
ISO
DDT results in increased methylation of ZFPM2 gene
CTD
PMID:30822522
NCBI chr 7:79,471,277...79,964,405
Ensembl chr 7:79,638,046...79,964,405
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Zpbp
zona pellucida binding protein
decreases methylation
EXP
DDT results in decreased methylation of ZPBP gene
CTD
PMID:30207508
NCBI chr14:91,360,670...91,556,406
Ensembl chr14:91,363,152...91,556,231
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Ar
androgen receptor
affects binding multiple interactions
ISO
Dicofol binds to AR protein Dicofol inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Dicofol inhibits the reaction [Metribolone results in increased activity of AR protein]; Dihydrotestosterone inhibits the reaction [Dicofol results in increased activity of AR protein]
CTD
PMID:15064155 PMID:15253041 PMID:18324785 PMID:21310686
NCBI chr X:67,656,253...67,828,998
Ensembl chr X:67,656,253...67,829,026
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Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
decreases activity
ISO
Dicofol results in decreased activity of CYP19A1 protein
CTD
PMID:10806373
NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
EXP
Dicofol results in increased expression of CYP1A1 mRNA; Dicofol results in increased expression of CYP1A1 protein
CTD
PMID:19595748
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases expression
EXP
Dicofol results in increased expression of CYP1A2 mRNA
CTD
PMID:19595748
NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
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Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
increases expression
EXP
Dicofol results in increased expression of CYP2B1 protein
CTD
PMID:19595748
NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
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Cyp2b2
cytochrome P450, family 2, subfamily b, polypeptide 2
increases expression
EXP
Dicofol results in increased expression of CYP2B2 protein
CTD
PMID:19595748
NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
increases expression
EXP
Dicofol results in increased expression of CYP2E1 protein
CTD
PMID:19595748
NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
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Cyp3a23-3a1
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
increases expression
EXP
Dicofol results in increased expression of CYP3A23-3A1 mRNA
CTD
PMID:19595748
NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
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Dio1
iodothyronine deiodinase 1
decreases activity
ISO
Dicofol results in decreased activity of DIO1 protein
CTD
PMID:29228274
NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
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Esr1
estrogen receptor 1
affects binding multiple interactions increases activity
ISO
Dicofol binds to ESR1 protein Dicofol binds to and results in increased activity of ESR1 protein Dicofol results in increased activity of ESR1 protein
CTD
PMID:10789375 PMID:15064155 PMID:15253041 PMID:16337670 PMID:29162470
NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
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Esr2
estrogen receptor 2
increases activity
ISO
Dicofol results in increased activity of ESR2 protein
CTD
PMID:15064155
NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
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Ggt1
gamma-glutamyltransferase 1
increases activity
EXP
Dicofol results in increased activity of GGT1 protein
CTD
PMID:2387028
NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
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Gpt
glutamic--pyruvic transaminase
increases activity
EXP
Dicofol results in increased activity of GPT protein
CTD
PMID:2387028
NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
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Ifnb1
interferon beta 1
multiple interactions
ISO
Dicofol inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]
CTD
PMID:18177342
NCBI chr 5:106,865,192...106,865,746
Ensembl chr 5:106,865,192...106,865,746
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Nfkb1
nuclear factor kappa B subunit 1
multiple interactions
ISO
Dicofol inhibits the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein]
CTD
PMID:17015962
NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
Dicofol binds to and results in increased activity of NR1I2 protein
CTD
PMID:21115097
NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
increases activity
ISO
Dicofol results in increased activity of NR1I3 protein
CTD
PMID:28927721
NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
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Prkcb
protein kinase C, beta
multiple interactions increases activity
ISO
Calcium inhibits the reaction [Dicofol results in increased activity of PRKCB protein]; Phosphatidylserines promotes the reaction [Dicofol results in increased activity of PRKCB protein]
CTD
PMID:1724372
NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
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Ttr
transthyretin
affects binding
EXP
Dicofol binds to TTR protein
CTD
PMID:2043046
NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177
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