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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:17alpha-hydroxypregnenolone
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Accession:CHEBI:28750 term browser browse the term
Definition:A hydroxypregnenolone carrying an alpha-hydroxy group at position 17.
Synonyms:exact_synonym: 3beta,17-dihydroxypregn-5-en-20-one
 related_synonym: (3beta)-3,17-dihydroxypregn-5-en-20-one;   17-hydroxypregnenolone;   5-pregnen-3beta,17alpha-diol-20-one;   Formula=C21H32O3;   InChI=1S/C21H32O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h4,15-18,23-24H,5-12H2,1-3H3/t15-,16+,17-,18-,19-,20-,21-/m0/s1;   InChIKey=JERGUCIJOXJXHF-TVWVXWENSA-N;   SMILES=CC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
 alt_id: CHEBI:19172;   CHEBI:789
 xref: Beilstein:2337329;   CAS:387-79-1;   HMDB:HMDB0000363;   KEGG:C05138;   LIPID_MAPS_instance:LMST02030089
 xref_mesh: MESH:D006907
 xref: MetaCyc:CPD66-23;   PMID:12213889;   PMID:20963882;   PMID:21787799;   PMID:23647561;   Reaxys:2337329;   Wikipedia:17-Hydroxypregnenolone



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17alpha-hydroxypregnenolone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 affects chemical synthesis
affects metabolic processing
decreases acetylation
multiple interactions
increases metabolic processing
ISO CYP17A1 protein affects the chemical synthesis of 17-alpha-Hydroxypregnenolone
CYP17A1 protein affects the metabolism of 17-alpha-Hydroxypregnenolone
CYP17A1 protein results in decreased acetylation of 17-alpha-Hydroxypregnenolone
[[abiraterone results in decreased activity of CYP17A1 protein] which results in decreased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone; [CYP17A1 protein results in increased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone; [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone; Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone]; Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone]; Duloxetine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone]; Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone]; Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone]; Venlafaxine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone]
CTD PMID:15562394 PMID:16030167 PMID:17194026 PMID:29100959 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19860
    chemical entity 19858
      group 19816
        inorganic group 19399
          oxo group 18897
            organic oxo compound 18897
              carbonyl compound 18897
                ketone 17186
                  hydroxypregnenolone 1
                    17alpha-hydroxypregnenolone 1
                      17alpha-hydroxypregnenolone 3-sulfate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19860
    subatomic particle 19858
      composite particle 19858
        hadron 19858
          baryon 19858
            nucleon 19858
              atomic nucleus 19858
                atom 19858
                  main group element atom 19804
                    p-block element atom 19804
                      carbon group element atom 19745
                        carbon atom 19741
                          organic molecular entity 19741
                            organic molecule 19692
                              organic cyclic compound 19503
                                organic polycyclic compound 17267
                                  steroid 14721
                                    hydroxy steroid 14468
                                      3-hydroxy steroid 12813
                                        3beta-hydroxy steroid 2535
                                          3beta-hydroxy-Delta(5)-steroid 2367
                                            pregnenolone 2073
                                              hydroxypregnenolone 1
                                                17alpha-hydroxypregnenolone 1
                                                  17alpha-hydroxypregnenolone 3-sulfate 0
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