Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:17alpha-hydroxypregnenolone
go back to main search page
Accession:CHEBI:28750 term browser browse the term
Definition:A hydroxypregnenolone carrying an alpha-hydroxy group at position 17.
Synonyms:exact_synonym: 3beta,17-dihydroxypregn-5-en-20-one
 related_synonym: (3beta)-3,17-dihydroxypregn-5-en-20-one;   17-hydroxypregnenolone;   5-pregnen-3beta,17alpha-diol-20-one;   Formula=C21H32O3;   InChI=1S/C21H32O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h4,15-18,23-24H,5-12H2,1-3H3/t15-,16+,17-,18-,19-,20-,21-/m0/s1;   InChIKey=JERGUCIJOXJXHF-TVWVXWENSA-N;   SMILES=CC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
 alt_id: CHEBI:19172;   CHEBI:789
 xref: Beilstein:2337329;   CAS:387-79-1;   HMDB:HMDB0000363;   KEGG:C05138;   LIPID_MAPS_instance:LMST02030089
 xref_mesh: MESH:D006907
 xref: MetaCyc:CPD66-23;   PMID:12213889;   PMID:20963882;   PMID:21787799;   PMID:23647561;   Reaxys:2337329;   Wikipedia:17-Hydroxypregnenolone


show annotations for term's descendants           Sort by:
 
17alpha-hydroxypregnenolone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 affects chemical synthesis
affects metabolic processing
decreases acetylation
multiple interactions
increases metabolic processing
ISO CYP17A1 protein affects the chemical synthesis of 17-alpha-Hydroxypregnenolone
CYP17A1 protein affects the metabolism of 17-alpha-Hydroxypregnenolone
CYP17A1 protein results in decreased acetylation of 17-alpha-Hydroxypregnenolone
[[abiraterone results in decreased activity of CYP17A1 protein] which results in decreased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone; [CYP17A1 protein results in increased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone; [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone; Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone]; Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone]; Duloxetine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone]; Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone]; Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone]; Venlafaxine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone]
CTD PMID:15562394 PMID:16030167 PMID:17194026 PMID:29100959 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    chemical entity 19841
      group 19755
        inorganic group 19190
          oxo group 18436
            organic oxo compound 18436
              carbonyl compound 18436
                ketone 16189
                  hydroxypregnenolone 1
                    17alpha-hydroxypregnenolone 1
                      17-hydroxypregnenolone 3-sulfate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            organic group 18537
                              organic divalent group 18528
                                organodiyl group 18528
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      ketone 16189
                                        oxyketone 8642
                                          alpha-oxyketone 8642
                                            alpha-hydroxy ketone 8642
                                              tertiary alpha-hydroxy ketone 8367
                                                17alpha-hydroxypregnenolone 1
                                                  17-hydroxypregnenolone 3-sulfate 0
paths to the root