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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:picolinic acid
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Accession:CHEBI:28747 term browser browse the term
Definition:A pyridinemonocarboxylic acid in which the carboxy group is located at position 2. It is an intermediate in the metabolism of tryptophan.
Synonyms:related_synonym: 2-Picolinic acid;   2-Pyridinecarboxylic acid;   2-carboxypyridine;   Formula=C6H5NO2;   InChI=1S/C6H5NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H,(H,8,9);   InChIKey=SIOXPEMLGUPBBT-UHFFFAOYSA-N;   PYRIDINE-2-CARBOXYLIC ACID;   SMILES=OC(=O)c1ccccn1;   alpha-picolinic acid;   alpha-pyridinecarboxylic acid;   o-pyridinecarboxylic acid
 alt_id: CHEBI:26128;   CHEBI:47159;   CHEBI:8201
 xref: Beilstein:109595;   CAS:98-98-6;   Gmelin:3318;   HMDB:HMDB0002243;   KEGG:C10164;   KNApSAcK:C00002063
 xref_mesh: MESH:C030614
 xref: MetaCyc:PICOLINATE;   PDBeChem:6PC;   PMID:15206716;   PMID:15206793;   PMID:15290459;   PMID:16303883;   PMID:23630570;   PMID:24119749;   PMID:7064867;   PMID:7969932;   Reaxys:109595;   Wikipedia:Picolinic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:38184


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picolinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 decreases expression ISO picolinic acid results in decreased expression of ABCA1 protein CTD PMID:16870493 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions EXP [picolinic acid co-treated with Linoleic Acids, Conjugated] results in increased expression of ADIPOQ protein CTD PMID:17199723 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP picolinic acid inhibits the reaction [Cisplatin results in increased expression of BAX protein] CTD PMID:20817559 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Casp3 caspase 3 decreases activity
increases activity
ISO picolinic acid results in decreased activity of CASP3 protein
picolinic acid results in increased activity of CASP3 protein
CTD PMID:19853652 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO picolinic acid inhibits the reaction [Glucose results in increased secretion of CCL2 protein] CTD PMID:17665966 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cd36 CD36 molecule affects localization ISO picolinic acid affects the localization of CD36 protein CTD PMID:20721637 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO ferrous sulfate inhibits the reaction [picolinic acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]]; picolinic acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:10799651 PMID:10823667 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 decreases glycation ISO picolinic acid results in decreased glycation of HBA1 protein CTD PMID:22944053 NCBI chr10:15,323,830...15,324,677 JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions EXP picolinic acid inhibits the reaction [Cisplatin results in increased expression of HSPD1 protein] CTD PMID:20817559 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions EXP picolinic acid promotes the reaction [INS1 protein results in increased expression of IGF1 mRNA] CTD PMID:20013160 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions EXP picolinic acid promotes the reaction [INS1 protein results in increased expression of IGF1R mRNA] CTD PMID:20013160 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Il6 interleukin 6 multiple interactions ISO picolinic acid inhibits the reaction [Glucose results in increased secretion of IL6 protein] CTD PMID:17665966 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Insr insulin receptor increases expression EXP picolinic acid results in increased expression of INSR mRNA CTD PMID:19283340 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP picolinic acid inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 protein] CTD PMID:22790776 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP picolinic acid inhibits the reaction [Streptozocin results in decreased expression of NFKBIA protein] CTD PMID:22790776 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Retn resistin decreases secretion ISO picolinic acid results in decreased secretion of RETN protein CTD PMID:19298540 NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions
affects localization
ISO [Glucose co-treated with picolinic acid] affects the localization of SLC2A4 protein
picolinic acid affects the localization of SLC2A4 protein
CTD PMID:16339278 PMID:16870493 PMID:19195868 PMID:20721637 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 affects localization ISO picolinic acid affects the localization of SREBF1 protein CTD PMID:16870493 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP picolinic acid inhibits the reaction [Cisplatin results in increased expression of TNF protein]; picolinic acid inhibits the reaction [Streptozocin results in increased secretion of TNF protein] CTD PMID:17854708 PMID:20817559 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Ubc ubiquitin C multiple interactions
decreases expression
EXP picolinic acid promotes the reaction [INS1 protein results in decreased expression of UBC mRNA]
picolinic acid results in decreased expression of UBC mRNA
CTD PMID:20013160 NCBI chr12:31,238,889...31,243,924
Ensembl chr12:31,239,152...31,243,925
JBrowse link
G Ucp3 uncoupling protein 3 increases expression EXP picolinic acid results in increased expression of UCP3 mRNA CTD PMID:19283340 NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762
JBrowse link
picloram term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxo1 forkhead box O1 decreases expression
multiple interactions
ISO Picloram results in decreased expression of FOXO1 mRNA
arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide promotes the reaction [Picloram results in decreased expression of FOXO1 mRNA]
CTD PMID:21318024 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 decreases expression
multiple interactions
ISO Picloram results in decreased expression of GRIN1 mRNA
arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide promotes the reaction [Picloram results in decreased expression of GRIN1 mRNA]
CTD PMID:21318024 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
JBrowse link
G Mt-atp6 mitochondrially encoded ATP synthase membrane subunit 6 multiple interactions
decreases expression
ISO arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide promotes the reaction [Picloram results in decreased expression of ATP6 mRNA] CTD PMID:21318024 Ensembl chr MT:7,919...8,599 JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I decreases expression
multiple interactions
ISO Picloram results in decreased expression of COX1 mRNA
arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide promotes the reaction [Picloram results in decreased expression of COX1 mRNA]
CTD PMID:21318024 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Mt-cyb mitochondrially encoded cytochrome b multiple interactions
decreases expression
ISO arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide promotes the reaction [Picloram results in decreased expression of CYTB mRNA] CTD PMID:21318024 NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278
JBrowse link
G Mt-nd1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 multiple interactions
decreases expression
ISO arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide inhibits the reaction [Picloram results in decreased expression of ND1 mRNA] CTD PMID:21318024 NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Picloram results in increased expression of PPARGC1A mRNA CTD PMID:21318024 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions
decreases expression
ISO arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide inhibits the reaction [Picloram results in decreased expression of PRDX1 mRNA] CTD PMID:21318024 NCBI chr 5:130,147,276...130,162,850
Ensembl chr 5:130,147,204...130,162,856
JBrowse link
G Prdx2 peroxiredoxin 2 multiple interactions
decreases expression
ISO arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide inhibits the reaction [Picloram results in decreased expression of PRDX2 mRNA] CTD PMID:21318024 NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194
JBrowse link
G Prdx3 peroxiredoxin 3 multiple interactions
decreases expression
ISO arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide inhibits the reaction [Picloram results in decreased expression of PRDX3 mRNA] CTD PMID:21318024 NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111
JBrowse link
G Prdx4 peroxiredoxin 4 multiple interactions
decreases expression
ISO arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide inhibits the reaction [Picloram results in decreased expression of PRDX4 mRNA] CTD PMID:21318024 NCBI chr  X:40,026,762...40,044,066
Ensembl chr  X:40,026,651...40,044,066
JBrowse link
G Prdx5 peroxiredoxin 5 decreases expression
multiple interactions
ISO Picloram results in decreased expression of PRDX5 mRNA
arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide inhibits the reaction [Picloram results in decreased expression of PRDX5 mRNA]
CTD PMID:21318024 NCBI chr 1:204,099,826...204,103,589
Ensembl chr 1:204,099,826...204,114,268
JBrowse link
G Prdx6 peroxiredoxin 6 multiple interactions
decreases expression
ISO arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide inhibits the reaction [Picloram results in decreased expression of PRDX6 mRNA] CTD PMID:21318024 NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      application 19481
        MALDI matrix material 949
          picolinic acid 34
            5-(2'-carboxyethyl)-4,6-dihydroxypicolinic acid 0
            5-(2'-formylethyl)-4,6-dihydroxypicolinic acid 0
            5-(3'-carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinic acid 0
            5-(3-carboxy-3-oxopropenyl)-4,6-dihydroxypyridine-2-carboxylic acid 0
            aminopyralid 0
            clopyralid 0
            picloram + 13
            picolinamide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        monocarboxylic acid 17636
                                          pyridinemonocarboxylic acid 402
                                            picolinic acid 34
                                              5-(2'-carboxyethyl)-4,6-dihydroxypicolinic acid 0
                                              5-(2'-formylethyl)-4,6-dihydroxypicolinic acid 0
                                              5-(3'-carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinic acid 0
                                              5-(3-carboxy-3-oxopropenyl)-4,6-dihydroxypyridine-2-carboxylic acid 0
                                              aminopyralid 0
                                              clopyralid 0
                                              picloram + 13
                                              picolinamide 0
paths to the root