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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:thromboxane B2
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Accession:CHEBI:28728 term browser browse the term
Definition:A member of the class of thromboxanes B that is (5Z,13E)-thromboxa-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9, 11 and 15.
Synonyms:exact_synonym: (5Z,13E,15S)-9alpha,11,15-trihydroxythromboxa-5,13-dien-1-oic acid
 related_synonym: Formula=C20H34O6;   InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1;   InChIKey=XNRNNGPBEPRNAR-JQBLCGNGSA-N;   SMILES=CCCCC[C@H](O)\\C=C\\[C@H]1OC(O)C[C@H](O)[C@@H]1C\\C=C/CCCC(O)=O;   TXB2
 alt_id: CHEBI:26994;   CHEBI:9576
 xref: CAS:54397-85-2;   HMDB:HMDB0003252;   KEGG:C05963;   LIPID_MAPS_instance:LMFA03030002
 xref_mesh: MESH:D013929
 xref: PMID:24433337;   PMID:24786190;   PMID:7847191;   Reaxys:1399489;   Wikipedia:Thromboxane_B2
 cyclic_relationship: is_conjugate_acid_of CHEBI:90696


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thromboxane B2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2 coagulation factor II increases chemical synthesis
multiple interactions
increases abundance
ISO F2 protein results in increased chemical synthesis of Thromboxane B2
Indomethacin inhibits the reaction [F2 protein results in increased abundance of Thromboxane B2]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [F2 protein results in increased abundance of Thromboxane B2]
CTD PMID:10027849, PMID:16293890 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G Il1b interleukin 1 beta increases abundance
multiple interactions
ISO IL1B protein results in increased abundance of Thromboxane B2
Triamcinolone Acetonide inhibits the reaction [IL1B protein results in increased abundance of Thromboxane B2]
CTD PMID:15337628 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il4 interleukin 4 multiple interactions ISO [Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2] CTD PMID:23688403 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Pla2g2a phospholipase A2 group IIA increases abundance
multiple interactions
ISO PLA2G2A protein results in increased abundance of Thromboxane B2
varespladib inhibits the reaction [PLA2G2A protein results in increased abundance of Thromboxane B2]
CTD PMID:10027849 NCBI chr 5:157,282,650...157,285,295
Ensembl chr 5:157,282,669...157,285,328
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO [PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of Thromboxane B2; arzanol inhibits the reaction [[PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of Thromboxane B2] CTD PMID:20933508 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid inhibits the reaction [[Lipopolysaccharides results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Thromboxane B2]; [L 745337 results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of Thromboxane B2; [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Thromboxane B2; [Lipopolysaccharides results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Thromboxane B2; [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Thromboxane B2
[PTGS2 gene mutant form results in increased susceptibility to Kainic Acid] which results in increased abundance of Thromboxane B2; PTGS2 gene mutant form inhibits the reaction [Nanotubes, Carbon inhibits the reaction [OVAL protein results in increased abundance of Thromboxane B2]]; PTGS2 gene mutant form inhibits the reaction [OVAL protein results in increased abundance of Thromboxane B2]
CTD PMID:8621535, PMID:18834901, PMID:19934399, PMID:23642096 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Tbxas1 thromboxane A synthase 1 multiple interactions ISO [Sulfasalazine results in decreased activity of TBXAS1 protein] which results in decreased chemical synthesis of Thromboxane B2 CTD PMID:2572437 NCBI chr 4:66,624,181...66,846,745
Ensembl chr 4:66,670,618...66,846,805
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases abundance
increases secretion
ISO 1-carboxyheptylimidazole inhibits the reaction [TNF protein results in increased secretion of Thromboxane B2]; cyanidin 3-O-glucoside inhibits the reaction [TNF protein results in increased abundance of Thromboxane B2]; Ketoconazole inhibits the reaction [TNF protein results in increased secretion of Thromboxane B2]; terbinafine inhibits the reaction [TNF protein results in increased secretion of Thromboxane B2]; wedelolactone inhibits the reaction [TNF protein results in increased abundance of Thromboxane B2] CTD PMID:16784723, PMID:27793764 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
11-dehydro-thromboxane B2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E multiple interactions ISO APOE gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]; Aspirin inhibits the reaction [APOE gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]; dazoxiben inhibits the reaction [APOE gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]; tempol inhibits the reaction [APOE gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]] CTD PMID:20530721 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions ISO Aspirin inhibits the reaction [LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]; dazoxiben inhibits the reaction [LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]; LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]; tempol inhibits the reaction [LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]] CTD PMID:20530721 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        biochemical role 19313
          metabolite 19294
            eukaryotic metabolite 18943
              animal metabolite 18747
                mammalian metabolite 18746
                  mouse metabolite 18410
                    thromboxane B2 10
                      11-dehydro-thromboxane B2 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        monocarboxylic acid 17476
                                          fatty acid 15990
                                            fatty acid derivative 1021
                                              icosanoid 453
                                                prostanoid 395
                                                  thromboxane 15
                                                    thromboxanes B 10
                                                      thromboxane B2 10
                                                        11-dehydro-thromboxane B2 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.