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G |
Abcg5 |
ATP binding cassette subfamily G member 5 |
multiple interactions |
ISO |
Dehydroepiandrosterone results in increased activity of [ABCG5 protein binds to ABCG8 protein] |
CTD |
PMID:17055487 |
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NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207
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G |
Abcg8 |
ATP binding cassette subfamily G member 8 |
multiple interactions |
ISO |
Dehydroepiandrosterone results in increased activity of [ABCG5 protein binds to ABCG8 protein] |
CTD |
PMID:17055487 |
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NCBI chr 6:7,961,413...7,980,708
Ensembl chr 6:7,961,413...7,980,708
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G |
Acox1 |
acyl-CoA oxidase 1 |
increases expression multiple interactions |
EXP ISO |
Dehydroepiandrosterone results in increased expression of ACOX1 mRNA Dehydroepiandrosterone results in increased expression of ACOX1 mRNA; Dehydroepiandrosterone results in increased expression of ACOX1 protein Dehydroepiandrosterone promotes the reaction [[ACOX1 protein results in increased metabolism of Palmitoyl Coenzyme A] which results in increased chemical synthesis of Hydrogen Peroxide] |
CTD |
PMID:10497882 PMID:16940010 |
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NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
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G |
Acsl1 |
acyl-CoA synthetase long-chain family member 1 |
increases expression |
EXP |
Dehydroepiandrosterone results in increased expression of ACSL1 mRNA |
CTD |
PMID:16940010 |
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NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246
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G |
Adrb3 |
adrenoceptor beta 3 |
increases expression |
EXP |
Dehydroepiandrosterone results in increased expression of ADRB3 mRNA |
CTD |
PMID:12659879 |
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NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
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G |
Agr2 |
anterior gradient 2, protein disulphide isomerase family member |
affects expression |
ISO |
Dehydroepiandrosterone affects the expression of AGR2 mRNA |
CTD |
PMID:17094431 |
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NCBI chr 6:55,465,782...55,487,087
Ensembl chr 6:55,465,782...55,487,714
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G |
Akr1c3 |
aldo-keto reductase family 1, member C3 |
affects metabolic processing |
EXP |
AKR1C18 protein affects the metabolism of Dehydroepiandrosterone |
CTD |
PMID:15261307 |
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NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
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G |
Ar |
androgen receptor |
multiple interactions increases response to substance affects binding |
ISO EXP |
[AR protein mutant form results in increased susceptibility to Dehydroepiandrosterone] which results in increased activity of AR protein mutant form; [bicalutamide binds to and results in decreased activity of AR protein] inhibits the reaction [Dehydroepiandrosterone results in decreased expression of CYP1A2 mRNA]; AR protein affects the reaction [Dehydroepiandrosterone results in increased expression of RACK1 mRNA]; AR protein affects the reaction [Dehydroepiandrosterone results in increased expression of RACK1 protein]; Dehydroepiandrosterone binds to and results in decreased activity of AR protein; Dehydroepiandrosterone promotes the reaction [AR protein binds to MIR21 promoter] Dehydroepiandrosterone binds to AR protein |
CTD |
PMID:14565775 PMID:15994348 PMID:23603339 PMID:25969534 PMID:27239218 PMID:27473015 |
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NCBI chr X:67,656,253...67,828,998
Ensembl chr X:67,656,253...67,829,026
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G |
Bad |
BCL2-associated agonist of cell death |
increases expression |
EXP |
Dehydroepiandrosterone results in increased expression of BAD mRNA |
CTD |
PMID:16940010 |
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NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
EXP |
Dehydroepiandrosterone results in increased expression of BAX protein |
CTD |
PMID:21062263 |
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NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases expression increases expression |
EXP |
Dexamethasone inhibits the reaction [Dehydroepiandrosterone results in increased expression of BCL2 protein]; Dihydrotestosterone inhibits the reaction [Dehydroepiandrosterone results in increased expression of BCL2 protein]; Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone results in increased expression of BCL2 protein] Dehydroepiandrosterone results in decreased expression of BCL2 protein |
CTD |
PMID:16407456 PMID:21062263 |
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NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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G |
Bcl2l1 |
Bcl2-like 1 |
increases expression multiple interactions |
EXP |
Dehydroepiandrosterone results in increased expression of BCL2L1 protein Dexamethasone inhibits the reaction [Dehydroepiandrosterone results in increased expression of BCL2L1 protein]; Dihydrotestosterone inhibits the reaction [Dehydroepiandrosterone results in increased expression of BCL2L1 protein]; Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone results in increased expression of BCL2L1 protein] |
CTD |
PMID:16407456 |
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NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
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G |
Cat |
catalase |
increases activity |
EXP |
Dehydroepiandrosterone results in increased activity of CAT protein |
CTD |
PMID:8929588 |
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NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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G |
Cdc20 |
cell division cycle 20 |
decreases expression |
EXP |
Dehydroepiandrosterone results in decreased expression of CDC20 mRNA |
CTD |
PMID:16940010 |
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NCBI chr 5:137,260,728...137,264,931
Ensembl chr 5:137,260,739...137,265,015
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO EXP |
Dehydroepiandrosterone results in increased expression of CDKN1A mRNA Dehydroepiandrosterone results in increased expression of CDKN1A protein |
CTD |
PMID:15752352 PMID:16457693 |
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NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
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G |
Cdkn2a |
cyclin-dependent kinase inhibitor 2A |
increases expression |
EXP |
Dehydroepiandrosterone results in increased expression of CDKN2A protein |
CTD |
PMID:16457693 |
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NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
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G |
Cyba |
cytochrome b-245 alpha chain |
multiple interactions increases expression |
EXP |
Metformin affects the reaction [Dehydroepiandrosterone results in increased expression of CYBA protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of CYBA mRNA]; Quercetin affects the reaction [Dehydroepiandrosterone results in increased expression of CYBA protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of CYBA mRNA] Dehydroepiandrosterone results in increased expression of CYBA mRNA; Dehydroepiandrosterone results in increased expression of CYBA protein |
CTD |
PMID:27634381 |
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NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
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G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
affects chemical synthesis multiple interactions affects metabolic processing decreases expression |
ISO EXP |
CYP17A1 protein affects the chemical synthesis of Dehydroepiandrosterone [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone; Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone]; Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone] CYP17A1 protein affects the metabolism of Dehydroepiandrosterone Dehydroepiandrosterone results in decreased expression of CYP17A1 mRNA |
CTD |
PMID:15261307 PMID:15562394 PMID:15625562 PMID:15666818 PMID:15934942 PMID:16030167 PMID:29100959 |
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NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
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G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
increases metabolic processing multiple interactions decreases activity |
ISO |
CYP19A1 protein results in increased metabolism of Dehydroepiandrosterone Lipopolysaccharides inhibits the reaction [Dehydroepiandrosterone results in decreased activity of CYP19A1 protein] |
CTD |
PMID:10657851 PMID:16397352 |
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NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions increases degradation decreases stability |
ISO |
Dehydroepiandrosterone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased activity of CYP1A1 protein]; Dehydroepiandrosterone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 mRNA]; Dehydroepiandrosterone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Dehydroepiandrosterone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] Dehydroepiandrosterone results in increased degradation of CYP1A1 mRNA Dehydroepiandrosterone results in decreased stability of CYP1A1 mRNA |
CTD |
PMID:10575002 PMID:11597580 |
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NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions increases degradation decreases expression |
ISO |
[bicalutamide binds to and results in decreased activity of AR protein] inhibits the reaction [Dehydroepiandrosterone results in decreased expression of CYP1A2 mRNA]; bicalutamide inhibits the reaction [Dehydroepiandrosterone results in increased degradation of CYP1A2 mRNA]; Dehydroepiandrosterone inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA] |
CTD |
PMID:23603339 |
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NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
multiple interactions increases expression |
ISO |
Dehydroepiandrosterone inhibits the reaction [benz(a)anthracene promotes the reaction [CYP1B1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]]; Dehydroepiandrosterone inhibits the reaction [benz(a)anthracene results in increased expression of CYP1B1 mRNA]; Dehydroepiandrosterone inhibits the reaction [CYP1B1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]; Dehydroepiandrosterone inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CYP1B1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]] Dehydroepiandrosterone results in increased expression of CYP1B1 mRNA |
CTD |
PMID:10497882 |
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NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
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G |
Cyp3a23-3a1 |
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 |
increases expression |
EXP |
Dehydroepiandrosterone results in increased expression of CYP3A23-3A1 mRNA |
CTD |
PMID:16940010 |
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NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
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G |
Cyp3a62 |
cytochrome P450, family 3, subfamily a, polypeptide 62 |
increases hydroxylation multiple interactions |
ISO |
CYP3A4 protein results in increased hydroxylation of Dehydroepiandrosterone Dehydroepiandrosterone promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] |
CTD |
PMID:15845858 PMID:19299527 |
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NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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G |
Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
increases hydroxylation |
ISO |
CYP3A5 protein results in increased hydroxylation of Dehydroepiandrosterone |
CTD |
PMID:15845858 |
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NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
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G |
Cyp4a1 |
cytochrome P450, family 4, subfamily a, polypeptide 1 |
multiple interactions increases expression |
EXP |
Okadaic Acid inhibits the reaction [Dehydroepiandrosterone results in increased expression of CYP4A1 mRNA] |
CTD |
PMID:8700121 PMID:18079279 |
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NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154
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G |
Cyp4a3 |
cytochrome P450, family 4, subfamily a, polypeptide 3 |
increases expression |
EXP |
Dehydroepiandrosterone results in increased expression of CYP4A3 mRNA |
CTD |
PMID:8700121 PMID:16940010 |
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NCBI chr 5:134,468,666...134,484,851
Ensembl chr 5:134,469,270...134,484,839
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G |
Cyp7b1 |
cytochrome P450 family 7 subfamily B member 1 |
increases hydroxylation |
ISO |
CYP7B1 protein results in increased hydroxylation of Dehydroepiandrosterone |
CTD |
PMID:10588945 |
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NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257
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G |
Dbnl |
drebrin-like |
decreases expression |
EXP |
Dehydroepiandrosterone results in decreased expression of DBNL mRNA |
CTD |
PMID:16940010 |
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NCBI chr14:86,029,335...86,044,364
Ensembl chr14:86,029,335...86,044,364
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G |
Dhcr24 |
24-dehydrocholesterol reductase |
affects expression |
ISO |
Dehydroepiandrosterone affects the expression of DHCR24 mRNA |
CTD |
PMID:17094431 |
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NCBI chr 5:126,164,708...126,188,926
Ensembl chr 5:126,164,674...126,191,206
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G |
Dhrs11 |
dehydrogenase/reductase 11 |
increases reduction |
ISO |
DHRS11 protein results in increased reduction of Dehydroepiandrosterone |
CTD |
PMID:30926317 |
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NCBI chr10:72,144,042...72,153,496
Ensembl chr10:72,144,042...72,153,375
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G |
Egfr |
epidermal growth factor receptor |
multiple interactions |
ISO |
EGFR protein promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA] |
CTD |
PMID:25969534 |
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NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
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G |
Ehhadh |
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase |
increases expression |
EXP |
Dehydroepiandrosterone results in increased expression of EHHADH mRNA |
CTD |
PMID:16940010 |
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NCBI chr11:82,945,104...82,978,364
Ensembl chr11:82,945,104...82,978,364
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G |
Epo |
erythropoietin |
multiple interactions |
ISO |
[Dehydroepiandrosterone co-treated with Testosterone co-treated with GH1] results in decreased expression of EPO protein |
CTD |
PMID:15161484 |
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NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions increases phosphorylation increases expression affects binding |
ISO |
Dehydroepiandrosterone binds to and results in increased activity of ESR1 protein; ESR1 protein alternative form promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; GPER1 protein promotes the reaction [Dehydroepiandrosterone results in increased expression of ESR1 mRNA alternative form] Dehydroepiandrosterone results in increased phosphorylation of ESR1 protein Dehydroepiandrosterone results in increased expression of ESR1 mRNA alternative form; Dehydroepiandrosterone results in increased expression of ESR1 protein alternative form Dehydroepiandrosterone binds to ESR1 protein |
CTD |
PMID:15994348 PMID:19913605 PMID:25969534 |
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NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
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G |
Esr2 |
estrogen receptor 2 |
multiple interactions |
ISO |
Dehydroepiandrosterone binds to and results in increased activity of ESR2 protein |
CTD |
PMID:15994348 |
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NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
Dehydroepiandrosterone promotes the reaction [FOS protein binds to MIR21 promoter] |
CTD |
PMID:25969534 |
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NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
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G |
G6pc1 |
glucose-6-phosphatase catalytic subunit 1 |
decreases expression |
ISO |
Dehydroepiandrosterone results in decreased expression of G6PC1 mRNA |
CTD |
PMID:11228057 |
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NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
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G |
G6pd |
glucose-6-phosphate dehydrogenase |
multiple interactions |
ISO |
Dehydroepiandrosterone inhibits the reaction [ascorbate-2-phosphate results in increased activity of G6PD protein] |
CTD |
PMID:19746226 |
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NCBI chr X:156,274,800...156,293,935
Ensembl chr X:156,274,800...156,293,926
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G |
Gh1 |
growth hormone 1 |
multiple interactions |
ISO |
[Dehydroepiandrosterone co-treated with Testosterone co-treated with GH1] results in decreased expression of EPO protein |
CTD |
PMID:15161484 |
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NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
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G |
Gpd1 |
glycerol-3-phosphate dehydrogenase 1 |
multiple interactions increases activity |
ISO |
benz(a)anthracene inhibits the reaction [Dehydroepiandrosterone results in increased activity of GPD1 protein]; Tetrachlorodibenzodioxin inhibits the reaction [Dehydroepiandrosterone results in increased activity of GPD1 protein] |
CTD |
PMID:10497882 |
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NCBI chr 7:141,368,928...141,377,931
Ensembl chr 7:141,370,491...141,377,928
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G |
Gper1 |
G protein-coupled estrogen receptor 1 |
multiple interactions increases expression |
ISO |
4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [Dehydroepiandrosterone results in increased expression of GPER1 mRNA]; GPER1 protein promotes the reaction [Dehydroepiandrosterone results in increased expression of ESR1 mRNA alternative form]; GPER1 protein promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA] Dehydroepiandrosterone results in increased expression of GPER1 mRNA; Dehydroepiandrosterone results in increased expression of GPER1 protein |
CTD |
PMID:25969534 |
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NCBI chr12:17,309,122...17,315,267
Ensembl chr12:17,309,834...17,311,112
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G |
Hadhb |
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta |
increases expression |
EXP |
Dehydroepiandrosterone results in increased expression of HADHB mRNA |
CTD |
PMID:16940010 |
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NCBI chr 6:27,555,408...27,589,539
Ensembl chr 6:27,555,412...27,582,995
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
multiple interactions |
ISO |
Dehydroepiandrosterone inhibits the reaction [25-hydroxycholesterol results in decreased activity of HMGCR protein]; Dehydroepiandrosterone inhibits the reaction [27-hydroxycholesterol results in decreased activity of HMGCR protein] |
CTD |
PMID:9059514 |
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NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
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G |
Hsd17b1 |
hydroxysteroid (17-beta) dehydrogenase 1 |
affects metabolic processing increases chemical synthesis |
ISO |
HSD17B1 protein affects the metabolism of Dehydroepiandrosterone HSD17B1 protein results in increased chemical synthesis of Dehydroepiandrosterone |
CTD |
PMID:16054388 |
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NCBI chr10:88,987,558...88,989,758
Ensembl chr10:88,987,558...88,989,757
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G |
Hsd17b12 |
hydroxysteroid (17-beta) dehydrogenase 12 |
increases metabolic processing |
ISO |
HSD17B12 protein results in increased metabolism of Dehydroepiandrosterone |
CTD |
PMID:17641292 |
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NCBI chr 3:82,924,699...83,048,465
Ensembl chr 3:82,924,687...83,048,435
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G |
Hsd17b2 |
hydroxysteroid (17-beta) dehydrogenase 2 |
affects metabolic processing increases chemical synthesis |
ISO |
HSD17B2 protein affects the metabolism of Dehydroepiandrosterone HSD17B2 protein results in increased chemical synthesis of Dehydroepiandrosterone |
CTD |
PMID:16054388 |
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NCBI chr19:50,246,404...50,317,892
Ensembl chr19:50,246,402...50,317,891
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G |
Hsd17b4 |
hydroxysteroid (17-beta) dehydrogenase 4 |
affects metabolic processing increases chemical synthesis |
ISO |
HSD17B4 protein affects the metabolism of Dehydroepiandrosterone HSD17B4 protein results in increased chemical synthesis of Dehydroepiandrosterone |
CTD |
PMID:16054388 |
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NCBI chr18:44,810,462...44,897,677
Ensembl chr18:44,810,388...44,897,640
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G |
Hsd3b1 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
affects metabolic processing |
EXP ISO |
HSD3B1 protein affects the metabolism of Dehydroepiandrosterone |
CTD |
PMID:15261307 PMID:16054388 |
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G |
Igfbp3 |
insulin-like growth factor binding protein 3 |
decreases secretion |
ISO |
Dehydroepiandrosterone results in decreased secretion of IGFBP3 protein |
CTD |
PMID:16368782 |
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NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
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G |
Il1b |
interleukin 1 beta |
increases expression multiple interactions |
EXP |
Dehydroepiandrosterone results in increased expression of IL1B protein Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of IL1B protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of IL1B protein] |
CTD |
PMID:27634381 |
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NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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G |
Il6 |
interleukin 6 |
increases expression multiple interactions |
EXP |
Dehydroepiandrosterone results in increased expression of IL6 protein Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of IL6 protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of IL6 protein] |
CTD |
PMID:27634381 |
|
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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G |
Irs1 |
insulin receptor substrate 1 |
multiple interactions decreases phosphorylation |
EXP |
Metformin inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of IRS1 protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of IRS1 protein] |
CTD |
PMID:27634381 |
|
NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases expression |
ISO |
Dehydroepiandrosterone promotes the reaction [JUN protein binds to MIR21 promoter] Dehydroepiandrosterone results in increased expression of JUN protein |
CTD |
PMID:25969534 |
|
NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
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G |
Kl |
Klotho |
multiple interactions |
ISO |
Dehydroepiandrosterone analog inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] |
CTD |
PMID:14701853 |
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NCBI chr12:942,974...987,206
Ensembl chr12:943,006...987,551
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G |
Lep |
leptin |
decreases expression |
EXP |
Dehydroepiandrosterone results in decreased expression of LEP protein |
CTD |
PMID:12659879 |
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NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
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G |
Mapk6 |
mitogen-activated protein kinase 6 |
decreases expression |
EXP |
Dehydroepiandrosterone results in decreased expression of MAPK6 mRNA |
CTD |
PMID:16940010 |
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NCBI chr 8:82,328,013...82,351,108
Ensembl chr 8:82,328,020...82,351,108
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G |
Mir200a |
microRNA 200a |
multiple interactions |
ISO |
[Pertussis Toxin co-treated with Dehydroepiandrosterone] results in increased expression of MIR200A mRNA; [wortmannin co-treated with Dehydroepiandrosterone] results in increased expression of MIR200A mRNA |
CTD |
PMID:25969534 |
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NCBI chr 5:173,489,366...173,489,454
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G |
Mir21 |
microRNA 21 |
multiple interactions increases expression |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; AG 1879 inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; bicalutamide inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; Dactinomycin inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; Dehydroepiandrosterone promotes the reaction [AR protein binds to MIR21 promoter]; Dehydroepiandrosterone promotes the reaction [FOS protein binds to MIR21 promoter]; Dehydroepiandrosterone promotes the reaction [JUN protein binds to MIR21 promoter]; EGFR protein promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; ESR1 protein alternative form promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; GPER1 protein promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; methyl-beta-cyclodextrin inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; RTKI cpd inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; Wortmannin inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA] |
CTD |
PMID:25969534 |
|
NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
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G |
Mir22 |
microRNA 22 |
multiple interactions increases expression |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR22 mRNA]; [Dactinomycin co-treated with Dehydroepiandrosterone] results in increased expression of MIR22 mRNA; [Dehydroepiandrosterone results in increased expression of MIR22 mRNA] which results in decreased expression of PDCD4 protein; [wortmannin co-treated with Dehydroepiandrosterone] results in increased expression of MIR22 mRNA; Dactinomycin promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR22 mRNA] |
CTD |
PMID:25969534 |
|
NCBI chr10:62,299,592...62,299,686
Ensembl chr10:62,299,592...62,299,686
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G |
Mirlet7d |
microRNA let-7d |
increases expression |
ISO |
Dehydroepiandrosterone results in increased expression of MIRLET7D mRNA |
CTD |
PMID:25969534 |
|
NCBI chr17:16,419,980...16,420,077
Ensembl chr17:16,419,980...16,420,077
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G |
Mt-co1 |
mitochondrially encoded cytochrome c oxidase I |
increases expression |
EXP |
Dehydroepiandrosterone results in increased expression of COX1 mRNA |
CTD |
PMID:16940010 |
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NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
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G |
Mt-co3 |
mitochondrially encoded cytochrome c oxidase III |
increases expression |
EXP |
Dehydroepiandrosterone results in increased expression of COX3 mRNA |
CTD |
PMID:16940010 |
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NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382
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G |
Nppb |
natriuretic peptide B |
decreases expression |
ISO |
Dehydroepiandrosterone results in decreased expression of NPPB mRNA |
CTD |
PMID:15364798 |
|
NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
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G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
increases expression multiple interactions |
ISO |
Dehydroepiandrosterone results in increased expression of NR3C1 protein Flutamide inhibits the reaction [Dehydroepiandrosterone results in increased expression of NR3C1 protein] |
CTD |
PMID:27239218 |
|
NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
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G |
Nts |
neurotensin |
affects expression |
ISO |
Dehydroepiandrosterone affects the expression of NTS mRNA |
CTD |
PMID:17094431 |
|
NCBI chr 7:44,111,594...44,120,998
Ensembl chr 7:44,111,151...44,121,130
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G |
Olr1 |
oxidized low density lipoprotein receptor 1 |
increases expression multiple interactions |
EXP |
Dehydroepiandrosterone results in increased expression of OLR1 mRNA; Dehydroepiandrosterone results in increased expression of OLR1 protein Metformin affects the reaction [Dehydroepiandrosterone results in increased expression of OLR1 protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of OLR1 mRNA]; Quercetin affects the reaction [Dehydroepiandrosterone results in increased expression of OLR1 protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of OLR1 mRNA] |
CTD |
PMID:27634381 |
|
NCBI chr 4:163,239,853...163,261,937
Ensembl chr 4:163,239,849...163,261,958
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G |
Orm1 |
orosomucoid 1 |
decreases expression |
EXP |
Dehydroepiandrosterone results in decreased expression of ORM1 mRNA |
CTD |
PMID:16940010 |
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NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820
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G |
Pdcd4 |
programmed cell death 4 |
decreases expression multiple interactions |
ISO |
Dehydroepiandrosterone results in decreased expression of PDCD4 mRNA; Dehydroepiandrosterone results in decreased expression of PDCD4 protein [Dehydroepiandrosterone results in increased expression of MIR22 mRNA] which results in decreased expression of PDCD4 protein |
CTD |
PMID:25969534 |
|
NCBI chr 1:274,616,625...274,648,204
Ensembl chr 1:274,625,224...274,648,204
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G |
Plcg2 |
phospholipase C, gamma 2 |
increases expression |
EXP |
Dehydroepiandrosterone results in increased expression of PLCG2 mRNA |
CTD |
PMID:16940010 |
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NCBI chr19:50,039,410...50,173,543
Ensembl chr19:50,045,020...50,173,220
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
increases activity multiple interactions increases expression decreases phosphorylation |
ISO EXP |
Dehydroepiandrosterone results in increased activity of PPARA protein [Dehydroepiandrosterone results in increased expression of PPP2CA mRNA] which results in decreased phosphorylation of PPARA protein; Okadaic Acid inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of PPARA protein]; Okadaic Acid inhibits the reaction [Dehydroepiandrosterone results in increased activity of PPARA protein] Dehydroepiandrosterone results in increased expression of PPARA mRNA; Dehydroepiandrosterone results in increased expression of PPARA protein |
CTD |
PMID:18079279 |
|
NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
increases expression |
EXP |
Dehydroepiandrosterone results in increased expression of PPARGC1A mRNA |
CTD |
PMID:12659879 |
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NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
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G |
Ppp2ca |
protein phosphatase 2 catalytic subunit alpha |
multiple interactions increases expression |
EXP |
[Dehydroepiandrosterone results in increased expression of PPP2CA mRNA] which results in decreased phosphorylation of PPARA protein |
CTD |
PMID:18079279 |
|
NCBI chr10:37,534,449...37,554,861
Ensembl chr10:37,535,871...37,554,664
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G |
Prl |
prolactin |
increases secretion |
ISO |
PRL protein results in increased secretion of Dehydroepiandrosterone |
CTD |
PMID:2948424 |
|
NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
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G |
Psme1 |
proteasome activator subunit 1 |
decreases expression |
EXP |
Dehydroepiandrosterone results in decreased expression of PSME1 mRNA |
CTD |
PMID:16940010 |
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NCBI chr15:34,256,071...34,258,947
Ensembl chr15:34,256,071...34,258,947
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G |
Rab38 |
RAB38, member RAS oncogene family |
decreases expression |
EXP |
Dehydroepiandrosterone results in decreased expression of RAB38 mRNA |
CTD |
PMID:16940010 |
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NCBI chr 1:152,072,716...152,153,449
Ensembl chr 1:152,072,665...152,153,449
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G |
Rack1 |
receptor for activated C kinase 1 |
increases expression multiple interactions |
ISO |
Dehydroepiandrosterone results in increased expression of RACK1 mRNA; Dehydroepiandrosterone results in increased expression of RACK1 protein AR protein affects the reaction [Dehydroepiandrosterone results in increased expression of RACK1 mRNA]; AR protein affects the reaction [Dehydroepiandrosterone results in increased expression of RACK1 protein]; Flutamide inhibits the reaction [Dehydroepiandrosterone results in increased expression of RACK1 mRNA]; Flutamide inhibits the reaction [Dehydroepiandrosterone results in increased expression of RACK1 protein] |
CTD |
PMID:27239218 PMID:28412309 |
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NCBI chr10:34,149,717...34,155,198
Ensembl chr10:34,149,717...34,155,198 Ensembl chr12:34,149,717...34,155,198
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G |
Rb1 |
RB transcriptional corepressor 1 |
increases expression multiple interactions |
EXP ISO |
Dehydroepiandrosterone results in increased expression of RB1 mRNA Dehydroepiandrosterone results in decreased expression of and results in decreased phosphorylation of RB1 protein |
CTD |
PMID:15752352 PMID:16940010 |
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NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions affects localization |
EXP |
Metformin inhibits the reaction [Dehydroepiandrosterone affects the localization of RELA protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone affects the localization of RELA protein] |
CTD |
PMID:27634381 |
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NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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G |
Rnpep |
arginyl aminopeptidase |
decreases expression |
EXP |
Dehydroepiandrosterone results in decreased expression of RNPEP mRNA |
CTD |
PMID:16940010 |
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NCBI chr13:52,092,863...52,124,006
Ensembl chr13:52,092,859...52,111,363
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G |
Rpl41 |
ribosomal protein L41 |
decreases expression |
EXP |
Dehydroepiandrosterone results in decreased expression of RPL41 mRNA |
CTD |
PMID:16940010 |
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NCBI chr 7:2,972,897...2,973,977
Ensembl chr 7:2,972,900...2,973,977
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G |
Sirt1 |
sirtuin 1 |
decreases expression affects expression |
ISO |
Dehydroepiandrosterone results in decreased expression of SIRT1 protein Dehydroepiandrosterone affects the expression of SIRT1 protein |
CTD |
PMID:20195491 |
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NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
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G |
Slc22a8 |
solute carrier family 22 member 8 |
multiple interactions |
ISO |
Dehydroepiandrosterone inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate] |
CTD |
PMID:11306713 |
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NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
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G |
Sod2 |
superoxide dismutase 2 |
decreases expression |
EXP |
Dehydroepiandrosterone results in decreased expression of SOD2 mRNA |
CTD |
PMID:16940010 |
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NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
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G |
Src |
SRC proto-oncogene, non-receptor tyrosine kinase |
increases phosphorylation multiple interactions |
EXP ISO |
Dehydroepiandrosterone results in increased phosphorylation of SRC protein 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [Dehydroepiandrosterone results in increased phosphorylation of SRC protein] Dihydrotestosterone inhibits the reaction [Dehydroepiandrosterone results in increased phosphorylation of SRC protein]; Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone results in increased phosphorylation of SRC protein] |
CTD |
PMID:16407456 PMID:25969534 |
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NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
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G |
Srd5a1 |
steroid 5 alpha-reductase 1 |
affects metabolic processing |
EXP |
SRD5A1 protein affects the metabolism of Dehydroepiandrosterone |
CTD |
PMID:15261307 |
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NCBI chr 1:36,320,504...36,354,694
Ensembl chr 1:36,320,461...36,354,756
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G |
Sts |
steroid sulfatase |
increases chemical synthesis |
ISO |
STS protein results in increased chemical synthesis of Dehydroepiandrosterone |
CTD |
PMID:16054388 |
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NCBI chr X:45,420,418...45,428,748
Ensembl chr X:45,420,596...45,428,750
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G |
Sult1e1 |
sulfotransferase family 1E member 1 |
increases sulfation |
ISO |
SULT1E1 protein results in increased sulfation of Dehydroepiandrosterone |
CTD |
PMID:8185618 |
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NCBI chr14:22,070,861...22,089,264
Ensembl chr14:22,072,024...22,089,248
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G |
Sult2a1 |
sulfotransferase family 2A member 1 |
multiple interactions increases metabolic processing increases sulfation |
ISO |
2,3'-dichlorobiphenyl metabolite inhibits the reaction [Dehydroepiandrosterone results in increased expression of SULT2A1 protein]; 2,3'-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; 2,3-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; 2,4'-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; 2,5-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein affects the metabolism of Dehydroepiandrosterone]; 2,5-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; 3',4'-dihydroxy-4-monochlorobiphenyl inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; 3,3'-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; 3,5-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; 4-chlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; Benzoquinones analog affects the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; Benzoquinones analog inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; Dehydroepiandrosterone inhibits the reaction [Benzoquinones analog inhibits the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT2A1 protein]]; Ethanol inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; Polychlorinated Biphenyls inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone] SULT2A1 protein results in increased metabolism of Dehydroepiandrosterone |
CTD |
PMID:10623578 PMID:10752640 PMID:14570759 PMID:17112228 PMID:19646966 PMID:20102295 PMID:21913674 PMID:24059442 PMID:24508592 PMID:30776358 |
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NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230
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G |
Sult2b1 |
sulfotransferase family 2B member 1 |
increases sulfation |
ISO |
SULT2B1 protein results in increased sulfation of Dehydroepiandrosterone |
CTD |
PMID:9799594 |
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NCBI chr 1:101,712,254...101,774,683
Ensembl chr 1:101,710,959...101,773,508
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G |
Tlr4 |
toll-like receptor 4 |
multiple interactions increases expression |
EXP |
Metformin affects the reaction [Dehydroepiandrosterone results in increased expression of TLR4 protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of TLR4 mRNA]; Quercetin affects the reaction [Dehydroepiandrosterone results in increased expression of TLR4 protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of TLR4 mRNA] Dehydroepiandrosterone results in increased expression of TLR4 mRNA; Dehydroepiandrosterone results in increased expression of TLR4 protein |
CTD |
PMID:27634381 |
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NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
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G |
Tnf |
tumor necrosis factor |
increases expression multiple interactions |
EXP ISO |
Dehydroepiandrosterone results in increased expression of TNF protein [Lipopolysaccharides co-treated with Dehydroepiandrosterone] results in increased secretion of TNF protein; Flutamide inhibits the reaction [[Lipopolysaccharides co-treated with Dehydroepiandrosterone] results in increased secretion of TNF protein] Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of TNF protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of TNF protein] |
CTD |
PMID:27239218 PMID:27634381 |
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NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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G |
Top2b |
DNA topoisomerase II beta |
decreases expression |
EXP |
Dehydroepiandrosterone results in decreased expression of TOP2B mRNA |
CTD |
PMID:16940010 |
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NCBI chr15:10,262,972...10,319,741
Ensembl chr15:10,262,651...10,320,233
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G |
Tp53 |
tumor protein p53 |
increases expression |
ISO |
Dehydroepiandrosterone results in increased expression of TP53 mRNA |
CTD |
PMID:15752352 |
|
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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G |
Txnip |
thioredoxin interacting protein |
decreases expression |
ISO |
Dehydroepiandrosterone results in decreased expression of TXNIP protein |
CTD |
PMID:20195491 |
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NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974
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G |
Ucp1 |
uncoupling protein 1 |
increases expression decreases expression |
EXP |
Dehydroepiandrosterone results in increased expression of UCP1 mRNA; Dehydroepiandrosterone results in increased expression of UCP1 protein Dehydroepiandrosterone results in decreased expression of UCP1 mRNA |
CTD |
PMID:12659879 |
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NCBI chr19:24,456,976...24,464,808
Ensembl chr19:24,456,976...24,464,807
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G |
Ucp2 |
uncoupling protein 2 |
decreases expression |
EXP |
Dehydroepiandrosterone results in decreased expression of UCP2 mRNA |
CTD |
PMID:12659879 |
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NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744
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G |
Ucp3 |
uncoupling protein 3 |
increases expression decreases expression |
EXP |
Dehydroepiandrosterone results in increased expression of UCP3 mRNA Dehydroepiandrosterone results in decreased expression of UCP3 mRNA |
CTD |
PMID:12659879 |
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NCBI chr 1:165,482,912...165,495,895
Ensembl chr 1:165,482,155...165,496,206
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G |
Vmp1 |
vacuole membrane protein 1 |
multiple interactions increases expression |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA]; AG 1879 inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA]; Dactinomycin inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA]; methyl-beta-cyclodextrin inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA]; Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA] |
CTD |
PMID:25969534 |
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NCBI chr10:73,901,988...74,001,900
Ensembl chr10:73,902,837...74,001,895
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G |
Xdh |
xanthine dehydrogenase |
decreases activity |
EXP |
Dehydroepiandrosterone results in decreased activity of XDH protein |
CTD |
PMID:8373410 |
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NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
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G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
decreases activity multiple interactions |
ISO |
Dehydroepiandrosterone Sulfate results in decreased activity of ABCB11 protein Dehydroepiandrosterone Sulfate inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] |
CTD |
PMID:24014644 |
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NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
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G |
Acox1 |
acyl-CoA oxidase 1 |
increases expression multiple interactions |
ISO |
Dehydroepiandrosterone Sulfate results in increased expression of ACOX1 mRNA PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of ACOX1 mRNA] |
CTD |
PMID:8700121 |
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NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
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G |
Bcl2 |
BCL2, apoptosis regulator |
increases expression multiple interactions |
EXP |
Dehydroepiandrosterone Sulfate results in increased expression of BCL2 protein Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone Sulfate results in increased expression of BCL2 protein] |
CTD |
PMID:16407456 |
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NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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G |
Bcl2l1 |
Bcl2-like 1 |
increases expression multiple interactions |
EXP |
Dehydroepiandrosterone Sulfate results in increased expression of BCL2L1 protein Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone Sulfate results in increased expression of BCL2L1 protein] |
CTD |
PMID:16407456 |
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NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
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G |
Cpt1a |
carnitine palmitoyltransferase 1A |
multiple interactions increases expression |
EXP |
[Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CPT1A protein Dehydroepiandrosterone Sulfate results in increased expression of CPT1A protein |
CTD |
PMID:25786523 |
|
NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
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G |
Cyp2c11 |
cytochrome P450, subfamily 2, polypeptide 11 |
multiple interactions |
EXP |
[Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP2C11 protein |
CTD |
PMID:25786523 |
|
NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
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G |
Cyp2c6v1 |
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 |
multiple interactions |
EXP |
[Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP2C6V1 protein |
CTD |
PMID:25786523 |
|
NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions |
EXP |
[Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP3A2 protein |
CTD |
PMID:25786523 |
|
NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
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G |
Cyp3a62 |
cytochrome P450, family 3, subfamily a, polypeptide 62 |
affects metabolic processing |
ISO |
CYP3A4 protein affects the metabolism of Dehydroepiandrosterone Sulfate |
CTD |
PMID:2271712 |
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NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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G |
Cyp4a1 |
cytochrome P450, family 4, subfamily a, polypeptide 1 |
increases expression multiple interactions |
EXP |
Dehydroepiandrosterone Sulfate results in increased expression of CYP4A1 mRNA; Dehydroepiandrosterone Sulfate results in increased expression of CYP4A1 protein [Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP4A1 protein |
CTD |
PMID:8700121 PMID:25786523 |
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NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154
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G |
Cyp4a3 |
cytochrome P450, family 4, subfamily a, polypeptide 3 |
increases expression |
EXP |
Dehydroepiandrosterone Sulfate results in increased expression of CYP4A3 mRNA |
CTD |
PMID:8700121 |
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NCBI chr 5:134,468,666...134,484,851
Ensembl chr 5:134,469,270...134,484,839
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Ehhadh |
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase |
increases expression multiple interactions |
ISO |
Dehydroepiandrosterone Sulfate results in increased expression of EHHADH mRNA PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of EHHADH mRNA] |
CTD |
PMID:8700121 |
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NCBI chr11:82,945,104...82,978,364
Ensembl chr11:82,945,104...82,978,364
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Fabp1 |
fatty acid binding protein 1 |
increases expression multiple interactions |
ISO |
Dehydroepiandrosterone Sulfate results in increased expression of FABP1 mRNA PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of FABP1 mRNA] |
CTD |
PMID:8700121 |
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NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
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Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
[Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased expression of FOS protein |
CTD |
PMID:15196791 |
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NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
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Il1b |
interleukin 1 beta |
multiple interactions increases abundance |
ISO |
Dexamethasone inhibits the reaction [IL1B protein results in increased abundance of Dehydroepiandrosterone Sulfate] |
CTD |
PMID:12548226 |
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NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
[Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:15196791 |
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NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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Nat1 |
N-acetyltransferase 1 |
multiple interactions |
ISO |
Dehydroepiandrosterone Sulfate inhibits the reaction [NAT1 protein results in increased acetylation of 4-Aminobenzoic Acid]; Dehydroepiandrosterone Sulfate promotes the reaction [NAT1 protein results in increased acetylation of 4-Aminobenzoic Acid] |
CTD |
PMID:11470991 |
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NCBI chr16:23,970,742...23,991,573
Ensembl chr16:23,970,743...23,991,573
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Pomc |
proopiomelanocortin |
increases abundance |
ISO |
POMC results in increased abundance of Dehydroepiandrosterone Sulfate |
CTD |
PMID:2161262 |
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NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
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Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions increases response to substance |
ISO |
PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of ACOX1 mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of CYP4A1 mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of CYP4A3 mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of EHHADH mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of FABP1 mRNA] PPARA protein results in increased susceptibility to Dehydroepiandrosterone Sulfate |
CTD |
PMID:8700121 |
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NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
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Prl |
prolactin |
increases abundance |
ISO |
PRL protein results in increased abundance of Dehydroepiandrosterone Sulfate |
CTD |
PMID:2943108 |
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NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
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Sirt1 |
sirtuin 1 |
increases expression |
EXP |
Dehydroepiandrosterone Sulfate results in increased expression of SIRT1 protein |
CTD |
PMID:25786523 |
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NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
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Sirt6 |
sirtuin 6 |
increases expression |
EXP |
Dehydroepiandrosterone Sulfate results in increased expression of SIRT6 protein |
CTD |
PMID:25786523 |
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NCBI chr 7:10,937,622...10,943,048
Ensembl chr 7:10,937,599...10,943,063
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Slc10a6 |
solute carrier family 10 member 6 |
increases transport |
ISO |
SLC10A6 protein results in increased transport of Dehydroepiandrosterone Sulfate |
CTD |
PMID:23562556 |
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NCBI chr14:7,618,022...7,682,377
Ensembl chr14:7,618,022...7,682,377
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Slc22a12 |
solute carrier family 22 member 12 |
multiple interactions |
ISO |
Potassium promotes the reaction [SLC22A12 protein results in increased uptake of Dehydroepiandrosterone Sulfate] |
CTD |
PMID:15284287 |
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NCBI chr 1:221,910,787...221,919,277
Ensembl chr 1:221,910,767...221,919,301
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Slc22a25 |
solute carrier family 22, member 25 |
increases uptake multiple interactions |
EXP ISO |
SLC22A9 protein results in increased uptake of Dehydroepiandrosterone Sulfate Dehydroepiandrosterone Sulfate inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate] |
CTD |
PMID:17132213 PMID:18441515 |
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NCBI chr 1:224,596,886...224,698,512
Ensembl chr 1:224,596,887...224,698,514
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Slc22a7 |
solute carrier family 22 member 7 |
increases transport |
ISO |
SLC22A7 protein results in increased transport of Dehydroepiandrosterone Sulfate |
CTD |
PMID:15901346 |
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NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766
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Slc22a8 |
solute carrier family 22 member 8 |
affects transport increases uptake |
ISO |
SLC22A8 protein affects the transport of Dehydroepiandrosterone Sulfate SLC22A8 protein results in increased uptake of Dehydroepiandrosterone Sulfate |
CTD |
PMID:11306713 PMID:16098483 PMID:17255469 |
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NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
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Slco1b2 |
solute carrier organic anion transporter family member 1B2 |
multiple interactions |
ISO |
Dehydroepiandrosterone Sulfate inhibits the reaction [SLCO1B3 protein results in increased susceptibility to cyanoginosin LR]; Dehydroepiandrosterone Sulfate inhibits the reaction [SLCO1B3 protein results in increased susceptibility to Okadaic Acid] |
CTD |
PMID:26134461 |
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NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
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Src |
SRC proto-oncogene, non-receptor tyrosine kinase |
increases phosphorylation |
EXP |
Dehydroepiandrosterone Sulfate results in increased phosphorylation of SRC protein |
CTD |
PMID:16407456 |
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NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
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Sts |
steroid sulfatase |
affects metabolic processing |
ISO |
STS protein affects the metabolism of Dehydroepiandrosterone Sulfate |
CTD |
PMID:16054388 |
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NCBI chr X:45,420,418...45,428,748
Ensembl chr X:45,420,596...45,428,750
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