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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dehydroepiandrosterone
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Accession:CHEBI:28689 term browser browse the term
Definition:An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
Synonyms:related_synonym: 3-BETA-HYDROXY-5-ANDROSTEN-17-ONE;   3beta-hydroxyandrost-5-en-17-one;   DHA;   DHEA;   Dehydroisoandrosterone;   Formula=C19H28O2;   InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1;   InChIKey=FMGSKLZLMKYGDP-USOAJAOKSA-N;   Intrarosa;   Prasterone;   SMILES=[H][C@@]12CC=C3C[C@@H](O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)C(=O)CC[C@@]21[H]
 alt_id: CHEBI:11911;   CHEBI:1723;   CHEBI:20246;   CHEBI:40738;   CHEBI:86953
 xref: CAS:53-43-0;   DrugBank:DB01708;   Drug_Central:795;   HMDB:HMDB0000077;   KEGG:C01227;   KEGG:D08409;   LIPID_MAPS_instance:LMST02020021
 xref_mesh: MESH:D003687
 xref: MetaCyc:3-BETA-HYDROXYANDROST-5-EN-17-ONE;   PDBeChem:AND;   PMID:14662261;   PMID:18634257;   PMID:24256992;   PMID:24424045;   Reaxys:2058110;   Wikipedia:Dehydroepiandrosterone

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dehydroepiandrosterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg5 ATP binding cassette subfamily G member 5 multiple interactions ISO Dehydroepiandrosterone results in increased activity of [ABCG5 protein binds to ABCG8 protein] CTD PMID:17055487 NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207 		JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 multiple interactions ISO Dehydroepiandrosterone results in increased activity of [ABCG5 protein binds to ABCG8 protein] CTD PMID:17055487 NCBI chr 6:7,961,413...7,980,708
Ensembl chr 6:7,961,413...7,980,708 		JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression
multiple interactions		 EXP
ISO		 Dehydroepiandrosterone results in increased expression of ACOX1 mRNA
Dehydroepiandrosterone results in increased expression of ACOX1 mRNA; Dehydroepiandrosterone results in increased expression of ACOX1 protein
Dehydroepiandrosterone promotes the reaction [[ACOX1 protein results in increased metabolism of Palmitoyl Coenzyme A] which results in increased chemical synthesis of Hydrogen Peroxide]		 CTD PMID:10497882 PMID:16940010 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases expression EXP Dehydroepiandrosterone results in increased expression of ACSL1 mRNA CTD PMID:16940010 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246 		JBrowse link
G Adrb3 adrenoceptor beta 3 increases expression EXP Dehydroepiandrosterone results in increased expression of ADRB3 mRNA CTD PMID:12659879 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632 		JBrowse link
G Agr2 anterior gradient 2, protein disulphide isomerase family member affects expression ISO Dehydroepiandrosterone affects the expression of AGR2 mRNA CTD PMID:17094431 NCBI chr 6:55,465,782...55,487,087
Ensembl chr 6:55,465,782...55,487,714 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 affects metabolic processing EXP AKR1C18 protein affects the metabolism of Dehydroepiandrosterone CTD PMID:15261307 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021 		JBrowse link
G Ar androgen receptor multiple interactions
increases response to substance
affects binding		 ISO
EXP		 [AR protein mutant form results in increased susceptibility to Dehydroepiandrosterone] which results in increased activity of AR protein mutant form; [bicalutamide binds to and results in decreased activity of AR protein] inhibits the reaction [Dehydroepiandrosterone results in decreased expression of CYP1A2 mRNA]; AR protein affects the reaction [Dehydroepiandrosterone results in increased expression of RACK1 mRNA]; AR protein affects the reaction [Dehydroepiandrosterone results in increased expression of RACK1 protein]; Dehydroepiandrosterone binds to and results in decreased activity of AR protein; Dehydroepiandrosterone promotes the reaction [AR protein binds to MIR21 promoter]
Dehydroepiandrosterone binds to AR protein		 CTD PMID:14565775 PMID:15994348 PMID:23603339 PMID:25969534 PMID:27239218 PMID:27473015 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression EXP Dehydroepiandrosterone results in increased expression of BAD mRNA CTD PMID:16940010 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP Dehydroepiandrosterone results in increased expression of BAX protein CTD PMID:21062263 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
increases expression		 EXP Dexamethasone inhibits the reaction [Dehydroepiandrosterone results in increased expression of BCL2 protein]; Dihydrotestosterone inhibits the reaction [Dehydroepiandrosterone results in increased expression of BCL2 protein]; Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone results in increased expression of BCL2 protein]
Dehydroepiandrosterone results in decreased expression of BCL2 protein		 CTD PMID:16407456 PMID:21062263 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression
multiple interactions		 EXP Dehydroepiandrosterone results in increased expression of BCL2L1 protein
Dexamethasone inhibits the reaction [Dehydroepiandrosterone results in increased expression of BCL2L1 protein]; Dihydrotestosterone inhibits the reaction [Dehydroepiandrosterone results in increased expression of BCL2L1 protein]; Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone results in increased expression of BCL2L1 protein]		 CTD PMID:16407456 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Cat catalase increases activity EXP Dehydroepiandrosterone results in increased activity of CAT protein CTD PMID:8929588 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cdc20 cell division cycle 20 decreases expression EXP Dehydroepiandrosterone results in decreased expression of CDC20 mRNA CTD PMID:16940010 NCBI chr 5:137,260,728...137,264,931
Ensembl chr 5:137,260,739...137,265,015 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO
EXP		 Dehydroepiandrosterone results in increased expression of CDKN1A mRNA
Dehydroepiandrosterone results in increased expression of CDKN1A protein		 CTD PMID:15752352 PMID:16457693 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression EXP Dehydroepiandrosterone results in increased expression of CDKN2A protein CTD PMID:16457693 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175 		JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions
increases expression		 EXP Metformin affects the reaction [Dehydroepiandrosterone results in increased expression of CYBA protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of CYBA mRNA]; Quercetin affects the reaction [Dehydroepiandrosterone results in increased expression of CYBA protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of CYBA mRNA]
Dehydroepiandrosterone results in increased expression of CYBA mRNA; Dehydroepiandrosterone results in increased expression of CYBA protein		 CTD PMID:27634381 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 affects chemical synthesis
multiple interactions
affects metabolic processing
decreases expression		 ISO
EXP		 CYP17A1 protein affects the chemical synthesis of Dehydroepiandrosterone
[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone; Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone]; Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone]
CYP17A1 protein affects the metabolism of Dehydroepiandrosterone
Dehydroepiandrosterone results in decreased expression of CYP17A1 mRNA		 CTD PMID:15261307 PMID:15562394 PMID:15625562 PMID:15666818 PMID:15934942 PMID:16030167 PMID:29100959 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases metabolic processing
multiple interactions
decreases activity		 ISO CYP19A1 protein results in increased metabolism of Dehydroepiandrosterone
Lipopolysaccharides inhibits the reaction [Dehydroepiandrosterone results in decreased activity of CYP19A1 protein]		 CTD PMID:10657851 PMID:16397352 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases degradation
decreases stability		 ISO Dehydroepiandrosterone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased activity of CYP1A1 protein]; Dehydroepiandrosterone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 mRNA]; Dehydroepiandrosterone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Dehydroepiandrosterone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Dehydroepiandrosterone results in increased degradation of CYP1A1 mRNA
Dehydroepiandrosterone results in decreased stability of CYP1A1 mRNA		 CTD PMID:10575002 PMID:11597580 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases degradation
decreases expression		 ISO [bicalutamide binds to and results in decreased activity of AR protein] inhibits the reaction [Dehydroepiandrosterone results in decreased expression of CYP1A2 mRNA]; bicalutamide inhibits the reaction [Dehydroepiandrosterone results in increased degradation of CYP1A2 mRNA]; Dehydroepiandrosterone inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA] CTD PMID:23603339 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases expression		 ISO Dehydroepiandrosterone inhibits the reaction [benz(a)anthracene promotes the reaction [CYP1B1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]]; Dehydroepiandrosterone inhibits the reaction [benz(a)anthracene results in increased expression of CYP1B1 mRNA]; Dehydroepiandrosterone inhibits the reaction [CYP1B1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]; Dehydroepiandrosterone inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CYP1B1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]]
Dehydroepiandrosterone results in increased expression of CYP1B1 mRNA		 CTD PMID:10497882 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Dehydroepiandrosterone results in increased expression of CYP3A23-3A1 mRNA CTD PMID:16940010 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases hydroxylation
multiple interactions		 ISO CYP3A4 protein results in increased hydroxylation of Dehydroepiandrosterone
Dehydroepiandrosterone promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]		 CTD PMID:15845858 PMID:19299527 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases hydroxylation ISO CYP3A5 protein results in increased hydroxylation of Dehydroepiandrosterone CTD PMID:15845858 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399 		JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 multiple interactions
increases expression		 EXP Okadaic Acid inhibits the reaction [Dehydroepiandrosterone results in increased expression of CYP4A1 mRNA] CTD PMID:8700121 PMID:18079279 NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154 		JBrowse link
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 increases expression EXP Dehydroepiandrosterone results in increased expression of CYP4A3 mRNA CTD PMID:8700121 PMID:16940010 NCBI chr 5:134,468,666...134,484,851
Ensembl chr 5:134,469,270...134,484,839 		JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 increases hydroxylation ISO CYP7B1 protein results in increased hydroxylation of Dehydroepiandrosterone CTD PMID:10588945 NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257 		JBrowse link
G Dbnl drebrin-like decreases expression EXP Dehydroepiandrosterone results in decreased expression of DBNL mRNA CTD PMID:16940010 NCBI chr14:86,029,335...86,044,364
Ensembl chr14:86,029,335...86,044,364 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase affects expression ISO Dehydroepiandrosterone affects the expression of DHCR24 mRNA CTD PMID:17094431 NCBI chr 5:126,164,708...126,188,926
Ensembl chr 5:126,164,674...126,191,206 		JBrowse link
G Dhrs11 dehydrogenase/reductase 11 increases reduction ISO DHRS11 protein results in increased reduction of Dehydroepiandrosterone CTD PMID:30926317 NCBI chr10:72,144,042...72,153,496
Ensembl chr10:72,144,042...72,153,375 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO EGFR protein promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA] CTD PMID:25969534 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796 		JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression EXP Dehydroepiandrosterone results in increased expression of EHHADH mRNA CTD PMID:16940010 NCBI chr11:82,945,104...82,978,364
Ensembl chr11:82,945,104...82,978,364 		JBrowse link
G Epo erythropoietin multiple interactions ISO [Dehydroepiandrosterone co-treated with Testosterone co-treated with GH1] results in decreased expression of EPO protein CTD PMID:15161484 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases phosphorylation
increases expression
affects binding		 ISO Dehydroepiandrosterone binds to and results in increased activity of ESR1 protein; ESR1 protein alternative form promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; GPER1 protein promotes the reaction [Dehydroepiandrosterone results in increased expression of ESR1 mRNA alternative form]
Dehydroepiandrosterone results in increased phosphorylation of ESR1 protein
Dehydroepiandrosterone results in increased expression of ESR1 mRNA alternative form; Dehydroepiandrosterone results in increased expression of ESR1 protein alternative form
Dehydroepiandrosterone binds to ESR1 protein		 CTD PMID:15994348 PMID:19913605 PMID:25969534 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Dehydroepiandrosterone binds to and results in increased activity of ESR2 protein CTD PMID:15994348 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Dehydroepiandrosterone promotes the reaction [FOS protein binds to MIR21 promoter] CTD PMID:25969534 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO Dehydroepiandrosterone results in decreased expression of G6PC1 mRNA CTD PMID:11228057 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions ISO Dehydroepiandrosterone inhibits the reaction [ascorbate-2-phosphate results in increased activity of G6PD protein] CTD PMID:19746226 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926 		JBrowse link
G Gh1 growth hormone 1 multiple interactions ISO [Dehydroepiandrosterone co-treated with Testosterone co-treated with GH1] results in decreased expression of EPO protein CTD PMID:15161484 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180 		JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 multiple interactions
increases activity		 ISO benz(a)anthracene inhibits the reaction [Dehydroepiandrosterone results in increased activity of GPD1 protein]; Tetrachlorodibenzodioxin inhibits the reaction [Dehydroepiandrosterone results in increased activity of GPD1 protein] CTD PMID:10497882 NCBI chr 7:141,368,928...141,377,931
Ensembl chr 7:141,370,491...141,377,928 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 multiple interactions
increases expression		 ISO 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [Dehydroepiandrosterone results in increased expression of GPER1 mRNA]; GPER1 protein promotes the reaction [Dehydroepiandrosterone results in increased expression of ESR1 mRNA alternative form]; GPER1 protein promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]
Dehydroepiandrosterone results in increased expression of GPER1 mRNA; Dehydroepiandrosterone results in increased expression of GPER1 protein		 CTD PMID:25969534 NCBI chr12:17,309,122...17,315,267
Ensembl chr12:17,309,834...17,311,112 		JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta increases expression EXP Dehydroepiandrosterone results in increased expression of HADHB mRNA CTD PMID:16940010 NCBI chr 6:27,555,408...27,589,539
Ensembl chr 6:27,555,412...27,582,995 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO Dehydroepiandrosterone inhibits the reaction [25-hydroxycholesterol results in decreased activity of HMGCR protein]; Dehydroepiandrosterone inhibits the reaction [27-hydroxycholesterol results in decreased activity of HMGCR protein] CTD PMID:9059514 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654 		JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 affects metabolic processing
increases chemical synthesis		 ISO HSD17B1 protein affects the metabolism of Dehydroepiandrosterone
HSD17B1 protein results in increased chemical synthesis of Dehydroepiandrosterone		 CTD PMID:16054388 NCBI chr10:88,987,558...88,989,758
Ensembl chr10:88,987,558...88,989,757 		JBrowse link
G Hsd17b12 hydroxysteroid (17-beta) dehydrogenase 12 increases metabolic processing ISO HSD17B12 protein results in increased metabolism of Dehydroepiandrosterone CTD PMID:17641292 NCBI chr 3:82,924,699...83,048,465
Ensembl chr 3:82,924,687...83,048,435 		JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 affects metabolic processing
increases chemical synthesis		 ISO HSD17B2 protein affects the metabolism of Dehydroepiandrosterone
HSD17B2 protein results in increased chemical synthesis of Dehydroepiandrosterone		 CTD PMID:16054388 NCBI chr19:50,246,404...50,317,892
Ensembl chr19:50,246,402...50,317,891 		JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 affects metabolic processing
increases chemical synthesis		 ISO HSD17B4 protein affects the metabolism of Dehydroepiandrosterone
HSD17B4 protein results in increased chemical synthesis of Dehydroepiandrosterone		 CTD PMID:16054388 NCBI chr18:44,810,462...44,897,677
Ensembl chr18:44,810,388...44,897,640 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 affects metabolic processing EXP
ISO		 HSD3B1 protein affects the metabolism of Dehydroepiandrosterone CTD PMID:15261307 PMID:16054388
G Igfbp3 insulin-like growth factor binding protein 3 decreases secretion ISO Dehydroepiandrosterone results in decreased secretion of IGFBP3 protein CTD PMID:16368782 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 EXP Dehydroepiandrosterone results in increased expression of IL1B protein
Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of IL1B protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of IL1B protein]		 CTD PMID:27634381 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 EXP Dehydroepiandrosterone results in increased expression of IL6 protein
Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of IL6 protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of IL6 protein]		 CTD PMID:27634381 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions
decreases phosphorylation		 EXP Metformin inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of IRS1 protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of IRS1 protein] CTD PMID:27634381 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 ISO Dehydroepiandrosterone promotes the reaction [JUN protein binds to MIR21 promoter]
Dehydroepiandrosterone results in increased expression of JUN protein		 CTD PMID:25969534 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Kl Klotho multiple interactions ISO Dehydroepiandrosterone analog inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] CTD PMID:14701853 NCBI chr12:942,974...987,206
Ensembl chr12:943,006...987,551 		JBrowse link
G Lep leptin decreases expression EXP Dehydroepiandrosterone results in decreased expression of LEP protein CTD PMID:12659879 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818 		JBrowse link
G Mapk6 mitogen-activated protein kinase 6 decreases expression EXP Dehydroepiandrosterone results in decreased expression of MAPK6 mRNA CTD PMID:16940010 NCBI chr 8:82,328,013...82,351,108
Ensembl chr 8:82,328,020...82,351,108 		JBrowse link
G Mir200a microRNA 200a multiple interactions ISO [Pertussis Toxin co-treated with Dehydroepiandrosterone] results in increased expression of MIR200A mRNA; [wortmannin co-treated with Dehydroepiandrosterone] results in increased expression of MIR200A mRNA CTD PMID:25969534 NCBI chr 5:173,489,366...173,489,454 JBrowse link
G Mir21 microRNA 21 multiple interactions
increases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; AG 1879 inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; bicalutamide inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; Dactinomycin inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; Dehydroepiandrosterone promotes the reaction [AR protein binds to MIR21 promoter]; Dehydroepiandrosterone promotes the reaction [FOS protein binds to MIR21 promoter]; Dehydroepiandrosterone promotes the reaction [JUN protein binds to MIR21 promoter]; EGFR protein promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; ESR1 protein alternative form promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; GPER1 protein promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; methyl-beta-cyclodextrin inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; RTKI cpd inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; Wortmannin inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA] CTD PMID:25969534 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301 		JBrowse link
G Mir22 microRNA 22 multiple interactions
increases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR22 mRNA]; [Dactinomycin co-treated with Dehydroepiandrosterone] results in increased expression of MIR22 mRNA; [Dehydroepiandrosterone results in increased expression of MIR22 mRNA] which results in decreased expression of PDCD4 protein; [wortmannin co-treated with Dehydroepiandrosterone] results in increased expression of MIR22 mRNA; Dactinomycin promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR22 mRNA] CTD PMID:25969534 NCBI chr10:62,299,592...62,299,686
Ensembl chr10:62,299,592...62,299,686 		JBrowse link
G Mirlet7d microRNA let-7d increases expression ISO Dehydroepiandrosterone results in increased expression of MIRLET7D mRNA CTD PMID:25969534 NCBI chr17:16,419,980...16,420,077
Ensembl chr17:16,419,980...16,420,077 		JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I increases expression EXP Dehydroepiandrosterone results in increased expression of COX1 mRNA CTD PMID:16940010 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867 		JBrowse link
G Mt-co3 mitochondrially encoded cytochrome c oxidase III increases expression EXP Dehydroepiandrosterone results in increased expression of COX3 mRNA CTD PMID:16940010 NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382 		JBrowse link
G Nppb natriuretic peptide B decreases expression ISO Dehydroepiandrosterone results in decreased expression of NPPB mRNA CTD PMID:15364798 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases expression
multiple interactions		 ISO Dehydroepiandrosterone results in increased expression of NR3C1 protein
Flutamide inhibits the reaction [Dehydroepiandrosterone results in increased expression of NR3C1 protein]		 CTD PMID:27239218 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647 		JBrowse link
G Nts neurotensin affects expression ISO Dehydroepiandrosterone affects the expression of NTS mRNA CTD PMID:17094431 NCBI chr 7:44,111,594...44,120,998
Ensembl chr 7:44,111,151...44,121,130 		JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 increases expression
multiple interactions		 EXP Dehydroepiandrosterone results in increased expression of OLR1 mRNA; Dehydroepiandrosterone results in increased expression of OLR1 protein
Metformin affects the reaction [Dehydroepiandrosterone results in increased expression of OLR1 protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of OLR1 mRNA]; Quercetin affects the reaction [Dehydroepiandrosterone results in increased expression of OLR1 protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of OLR1 mRNA]		 CTD PMID:27634381 NCBI chr 4:163,239,853...163,261,937
Ensembl chr 4:163,239,849...163,261,958 		JBrowse link
G Orm1 orosomucoid 1 decreases expression EXP Dehydroepiandrosterone results in decreased expression of ORM1 mRNA CTD PMID:16940010 NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820 		JBrowse link
G Pdcd4 programmed cell death 4 decreases expression
multiple interactions		 ISO Dehydroepiandrosterone results in decreased expression of PDCD4 mRNA; Dehydroepiandrosterone results in decreased expression of PDCD4 protein
[Dehydroepiandrosterone results in increased expression of MIR22 mRNA] which results in decreased expression of PDCD4 protein		 CTD PMID:25969534 NCBI chr 1:274,616,625...274,648,204
Ensembl chr 1:274,625,224...274,648,204 		JBrowse link
G Plcg2 phospholipase C, gamma 2 increases expression EXP Dehydroepiandrosterone results in increased expression of PLCG2 mRNA CTD PMID:16940010 NCBI chr19:50,039,410...50,173,543
Ensembl chr19:50,045,020...50,173,220 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases activity
multiple interactions
increases expression
decreases phosphorylation		 ISO
EXP		 Dehydroepiandrosterone results in increased activity of PPARA protein
[Dehydroepiandrosterone results in increased expression of PPP2CA mRNA] which results in decreased phosphorylation of PPARA protein; Okadaic Acid inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of PPARA protein]; Okadaic Acid inhibits the reaction [Dehydroepiandrosterone results in increased activity of PPARA protein]
Dehydroepiandrosterone results in increased expression of PPARA mRNA; Dehydroepiandrosterone results in increased expression of PPARA protein		 CTD PMID:18079279 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression EXP Dehydroepiandrosterone results in increased expression of PPARGC1A mRNA CTD PMID:12659879 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009 		JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha multiple interactions
increases expression		 EXP [Dehydroepiandrosterone results in increased expression of PPP2CA mRNA] which results in decreased phosphorylation of PPARA protein CTD PMID:18079279 NCBI chr10:37,534,449...37,554,861
Ensembl chr10:37,535,871...37,554,664 		JBrowse link
G Prl prolactin increases secretion ISO PRL protein results in increased secretion of Dehydroepiandrosterone CTD PMID:2948424 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299 		JBrowse link
G Psme1 proteasome activator subunit 1 decreases expression EXP Dehydroepiandrosterone results in decreased expression of PSME1 mRNA CTD PMID:16940010 NCBI chr15:34,256,071...34,258,947
Ensembl chr15:34,256,071...34,258,947 		JBrowse link
G Rab38 RAB38, member RAS oncogene family decreases expression EXP Dehydroepiandrosterone results in decreased expression of RAB38 mRNA CTD PMID:16940010 NCBI chr 1:152,072,716...152,153,449
Ensembl chr 1:152,072,665...152,153,449 		JBrowse link
G Rack1 receptor for activated C kinase 1 increases expression
multiple interactions		 ISO Dehydroepiandrosterone results in increased expression of RACK1 mRNA; Dehydroepiandrosterone results in increased expression of RACK1 protein
AR protein affects the reaction [Dehydroepiandrosterone results in increased expression of RACK1 mRNA]; AR protein affects the reaction [Dehydroepiandrosterone results in increased expression of RACK1 protein]; Flutamide inhibits the reaction [Dehydroepiandrosterone results in increased expression of RACK1 mRNA]; Flutamide inhibits the reaction [Dehydroepiandrosterone results in increased expression of RACK1 protein]		 CTD PMID:27239218 PMID:28412309 NCBI chr10:34,149,717...34,155,198
Ensembl chr10:34,149,717...34,155,198
Ensembl chr12:34,149,717...34,155,198 		JBrowse link
G Rb1 RB transcriptional corepressor 1 increases expression
multiple interactions		 EXP
ISO		 Dehydroepiandrosterone results in increased expression of RB1 mRNA
Dehydroepiandrosterone results in decreased expression of and results in decreased phosphorylation of RB1 protein		 CTD PMID:15752352 PMID:16940010 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization		 EXP Metformin inhibits the reaction [Dehydroepiandrosterone affects the localization of RELA protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone affects the localization of RELA protein] CTD PMID:27634381 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Rnpep arginyl aminopeptidase decreases expression EXP Dehydroepiandrosterone results in decreased expression of RNPEP mRNA CTD PMID:16940010 NCBI chr13:52,092,863...52,124,006
Ensembl chr13:52,092,859...52,111,363 		JBrowse link
G Rpl41 ribosomal protein L41 decreases expression EXP Dehydroepiandrosterone results in decreased expression of RPL41 mRNA CTD PMID:16940010 NCBI chr 7:2,972,897...2,973,977
Ensembl chr 7:2,972,900...2,973,977 		JBrowse link
G Sirt1 sirtuin 1 decreases expression
affects expression		 ISO Dehydroepiandrosterone results in decreased expression of SIRT1 protein
Dehydroepiandrosterone affects the expression of SIRT1 protein		 CTD PMID:20195491 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions ISO Dehydroepiandrosterone inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate] CTD PMID:11306713 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482 		JBrowse link
G Sod2 superoxide dismutase 2 decreases expression EXP Dehydroepiandrosterone results in decreased expression of SOD2 mRNA CTD PMID:16940010 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase increases phosphorylation
multiple interactions		 EXP
ISO		 Dehydroepiandrosterone results in increased phosphorylation of SRC protein
4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [Dehydroepiandrosterone results in increased phosphorylation of SRC protein]
Dihydrotestosterone inhibits the reaction [Dehydroepiandrosterone results in increased phosphorylation of SRC protein]; Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone results in increased phosphorylation of SRC protein]		 CTD PMID:16407456 PMID:25969534 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642 		JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 affects metabolic processing EXP SRD5A1 protein affects the metabolism of Dehydroepiandrosterone CTD PMID:15261307 NCBI chr 1:36,320,504...36,354,694
Ensembl chr 1:36,320,461...36,354,756 		JBrowse link
G Sts steroid sulfatase increases chemical synthesis ISO STS protein results in increased chemical synthesis of Dehydroepiandrosterone CTD PMID:16054388 NCBI chr  X:45,420,418...45,428,748
Ensembl chr  X:45,420,596...45,428,750 		JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 increases sulfation ISO SULT1E1 protein results in increased sulfation of Dehydroepiandrosterone CTD PMID:8185618 NCBI chr14:22,070,861...22,089,264
Ensembl chr14:22,072,024...22,089,248 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 multiple interactions
increases metabolic processing
increases sulfation		 ISO 2,3'-dichlorobiphenyl metabolite inhibits the reaction [Dehydroepiandrosterone results in increased expression of SULT2A1 protein]; 2,3'-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; 2,3-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; 2,4'-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; 2,5-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein affects the metabolism of Dehydroepiandrosterone]; 2,5-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; 3',4'-dihydroxy-4-monochlorobiphenyl inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; 3,3'-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; 3,5-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; 4-chlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; Benzoquinones analog affects the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; Benzoquinones analog inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; Dehydroepiandrosterone inhibits the reaction [Benzoquinones analog inhibits the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT2A1 protein]]; Ethanol inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; Polychlorinated Biphenyls inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]
SULT2A1 protein results in increased metabolism of Dehydroepiandrosterone		 CTD PMID:10623578 PMID:10752640 PMID:14570759 PMID:17112228 PMID:19646966 PMID:20102295 PMID:21913674 PMID:24059442 PMID:24508592 PMID:30776358 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230 		JBrowse link
G Sult2b1 sulfotransferase family 2B member 1 increases sulfation ISO SULT2B1 protein results in increased sulfation of Dehydroepiandrosterone CTD PMID:9799594 NCBI chr 1:101,712,254...101,774,683
Ensembl chr 1:101,710,959...101,773,508 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions
increases expression		 EXP Metformin affects the reaction [Dehydroepiandrosterone results in increased expression of TLR4 protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of TLR4 mRNA]; Quercetin affects the reaction [Dehydroepiandrosterone results in increased expression of TLR4 protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of TLR4 mRNA]
Dehydroepiandrosterone results in increased expression of TLR4 mRNA; Dehydroepiandrosterone results in increased expression of TLR4 protein		 CTD PMID:27634381 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 EXP
ISO		 Dehydroepiandrosterone results in increased expression of TNF protein
[Lipopolysaccharides co-treated with Dehydroepiandrosterone] results in increased secretion of TNF protein; Flutamide inhibits the reaction [[Lipopolysaccharides co-treated with Dehydroepiandrosterone] results in increased secretion of TNF protein]
Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of TNF protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of TNF protein]		 CTD PMID:27239218 PMID:27634381 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Top2b DNA topoisomerase II beta decreases expression EXP Dehydroepiandrosterone results in decreased expression of TOP2B mRNA CTD PMID:16940010 NCBI chr15:10,262,972...10,319,741
Ensembl chr15:10,262,651...10,320,233 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO Dehydroepiandrosterone results in increased expression of TP53 mRNA CTD PMID:15752352 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Txnip thioredoxin interacting protein decreases expression ISO Dehydroepiandrosterone results in decreased expression of TXNIP protein CTD PMID:20195491 NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974 		JBrowse link
G Ucp1 uncoupling protein 1 increases expression
decreases expression		 EXP Dehydroepiandrosterone results in increased expression of UCP1 mRNA; Dehydroepiandrosterone results in increased expression of UCP1 protein
Dehydroepiandrosterone results in decreased expression of UCP1 mRNA		 CTD PMID:12659879 NCBI chr19:24,456,976...24,464,808
Ensembl chr19:24,456,976...24,464,807 		JBrowse link
G Ucp2 uncoupling protein 2 decreases expression EXP Dehydroepiandrosterone results in decreased expression of UCP2 mRNA CTD PMID:12659879 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744 		JBrowse link
G Ucp3 uncoupling protein 3 increases expression
decreases expression		 EXP Dehydroepiandrosterone results in increased expression of UCP3 mRNA
Dehydroepiandrosterone results in decreased expression of UCP3 mRNA		 CTD PMID:12659879 NCBI chr 1:165,482,912...165,495,895
Ensembl chr 1:165,482,155...165,496,206 		JBrowse link
G Vmp1 vacuole membrane protein 1 multiple interactions
increases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA]; AG 1879 inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA]; Dactinomycin inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA]; methyl-beta-cyclodextrin inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA]; Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA] CTD PMID:25969534 NCBI chr10:73,901,988...74,001,900
Ensembl chr10:73,902,837...74,001,895 		JBrowse link
G Xdh xanthine dehydrogenase decreases activity EXP Dehydroepiandrosterone results in decreased activity of XDH protein CTD PMID:8373410 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494 		JBrowse link
dehydroepiandrosterone sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions		 ISO Dehydroepiandrosterone Sulfate results in decreased activity of ABCB11 protein
Dehydroepiandrosterone Sulfate inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]		 CTD PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946 		JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression
multiple interactions		 ISO Dehydroepiandrosterone Sulfate results in increased expression of ACOX1 mRNA
PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of ACOX1 mRNA]		 CTD PMID:8700121 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions		 EXP Dehydroepiandrosterone Sulfate results in increased expression of BCL2 protein
Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone Sulfate results in increased expression of BCL2 protein]		 CTD PMID:16407456 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression
multiple interactions		 EXP Dehydroepiandrosterone Sulfate results in increased expression of BCL2L1 protein
Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone Sulfate results in increased expression of BCL2L1 protein]		 CTD PMID:16407456 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions
increases expression		 EXP [Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CPT1A protein
Dehydroepiandrosterone Sulfate results in increased expression of CPT1A protein		 CTD PMID:25786523 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions EXP [Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP2C11 protein CTD PMID:25786523 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions EXP [Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP2C6V1 protein CTD PMID:25786523 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP [Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP3A2 protein CTD PMID:25786523 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 affects metabolic processing ISO CYP3A4 protein affects the metabolism of Dehydroepiandrosterone Sulfate CTD PMID:2271712 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases expression
multiple interactions		 EXP Dehydroepiandrosterone Sulfate results in increased expression of CYP4A1 mRNA; Dehydroepiandrosterone Sulfate results in increased expression of CYP4A1 protein
[Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP4A1 protein		 CTD PMID:8700121 PMID:25786523 NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154 		JBrowse link
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 increases expression EXP Dehydroepiandrosterone Sulfate results in increased expression of CYP4A3 mRNA CTD PMID:8700121 NCBI chr 5:134,468,666...134,484,851
Ensembl chr 5:134,469,270...134,484,839 		JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression
multiple interactions		 ISO Dehydroepiandrosterone Sulfate results in increased expression of EHHADH mRNA
PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of EHHADH mRNA]		 CTD PMID:8700121 NCBI chr11:82,945,104...82,978,364
Ensembl chr11:82,945,104...82,978,364 		JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression
multiple interactions		 ISO Dehydroepiandrosterone Sulfate results in increased expression of FABP1 mRNA
PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of FABP1 mRNA]		 CTD PMID:8700121 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased expression of FOS protein CTD PMID:15196791 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases abundance		 ISO Dexamethasone inhibits the reaction [IL1B protein results in increased abundance of Dehydroepiandrosterone Sulfate] CTD PMID:12548226 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased phosphorylation of MAPK1 protein CTD PMID:15196791 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Nat1 N-acetyltransferase 1 multiple interactions ISO Dehydroepiandrosterone Sulfate inhibits the reaction [NAT1 protein results in increased acetylation of 4-Aminobenzoic Acid]; Dehydroepiandrosterone Sulfate promotes the reaction [NAT1 protein results in increased acetylation of 4-Aminobenzoic Acid] CTD PMID:11470991 NCBI chr16:23,970,742...23,991,573
Ensembl chr16:23,970,743...23,991,573 		JBrowse link
G Pomc proopiomelanocortin increases abundance ISO POMC results in increased abundance of Dehydroepiandrosterone Sulfate CTD PMID:2161262 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases response to substance		 ISO PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of ACOX1 mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of CYP4A1 mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of CYP4A3 mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of EHHADH mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of FABP1 mRNA]
PPARA protein results in increased susceptibility to Dehydroepiandrosterone Sulfate		 CTD PMID:8700121 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752 		JBrowse link
G Prl prolactin increases abundance ISO PRL protein results in increased abundance of Dehydroepiandrosterone Sulfate CTD PMID:2943108 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299 		JBrowse link
G Sirt1 sirtuin 1 increases expression EXP Dehydroepiandrosterone Sulfate results in increased expression of SIRT1 protein CTD PMID:25786523 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199 		JBrowse link
G Sirt6 sirtuin 6 increases expression EXP Dehydroepiandrosterone Sulfate results in increased expression of SIRT6 protein CTD PMID:25786523 NCBI chr 7:10,937,622...10,943,048
Ensembl chr 7:10,937,599...10,943,063 		JBrowse link
G Slc10a6 solute carrier family 10 member 6 increases transport ISO SLC10A6 protein results in increased transport of Dehydroepiandrosterone Sulfate CTD PMID:23562556 NCBI chr14:7,618,022...7,682,377
Ensembl chr14:7,618,022...7,682,377 		JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions ISO Potassium promotes the reaction [SLC22A12 protein results in increased uptake of Dehydroepiandrosterone Sulfate] CTD PMID:15284287 NCBI chr 1:221,910,787...221,919,277
Ensembl chr 1:221,910,767...221,919,301 		JBrowse link
G Slc22a25 solute carrier family 22, member 25 increases uptake
multiple interactions		 EXP
ISO		 SLC22A9 protein results in increased uptake of Dehydroepiandrosterone Sulfate
Dehydroepiandrosterone Sulfate inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]		 CTD PMID:17132213 PMID:18441515 NCBI chr 1:224,596,886...224,698,512
Ensembl chr 1:224,596,887...224,698,514 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 increases transport ISO SLC22A7 protein results in increased transport of Dehydroepiandrosterone Sulfate CTD PMID:15901346 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 affects transport
increases uptake		 ISO SLC22A8 protein affects the transport of Dehydroepiandrosterone Sulfate
SLC22A8 protein results in increased uptake of Dehydroepiandrosterone Sulfate		 CTD PMID:11306713 PMID:16098483 PMID:17255469 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO Dehydroepiandrosterone Sulfate inhibits the reaction [SLCO1B3 protein results in increased susceptibility to cyanoginosin LR]; Dehydroepiandrosterone Sulfate inhibits the reaction [SLCO1B3 protein results in increased susceptibility to Okadaic Acid] CTD PMID:26134461 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase increases phosphorylation EXP Dehydroepiandrosterone Sulfate results in increased phosphorylation of SRC protein CTD PMID:16407456 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642 		JBrowse link
G Sts steroid sulfatase affects metabolic processing ISO STS protein affects the metabolism of Dehydroepiandrosterone Sulfate CTD PMID:16054388 NCBI chr  X:45,420,418...45,428,748
Ensembl chr  X:45,420,596...45,428,750 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19792
      biological role 19792
        molecular messenger 18291
          hormone 18046
            sex hormone 17924
              androgen 3945
                dehydroepiandrosterone 115
                  16alpha-hydroxydehydroepiandrosterone 3-sulfate 0
                  7alpha-hydroxydehydroepiandrosterone 0
                  dehydroepiandrosterone 3-beta-D-glucoside 0
                  dehydroepiandrosterone 7-O-(carboxymethyl)oxime 0
                  dehydroepiandrosterone sulfate 30
                  dehydroisoandrosterone 3-glucuronide 0
                  prasterone sodium sulfate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            organic molecule 19556
                              organic cyclic compound 19365
                                organic polycyclic compound 16408
                                  steroid 12810
                                    hydroxy steroid 12393
                                      3-hydroxy steroid 10017
                                        3beta-hydroxy steroid 1994
                                          3beta-hydroxy-Delta(5)-steroid 1840
                                            dehydroepiandrosterone 115
                                              16alpha-hydroxydehydroepiandrosterone 3-sulfate 0
                                              7alpha-hydroxydehydroepiandrosterone 0
                                              dehydroepiandrosterone 3-beta-D-glucoside 0
                                              dehydroepiandrosterone 7-O-(carboxymethyl)oxime 0
                                              dehydroepiandrosterone sulfate 30
                                              dehydroisoandrosterone 3-glucuronide 0
                                              prasterone sodium sulfate 0
paths to the root