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G |
Abcg5 |
ATP binding cassette subfamily G member 5 |
multiple interactions |
ISO |
Dehydroepiandrosterone results in increased activity of [ABCG5 protein binds to ABCG8 protein] |
CTD |
PMID:17055487 |
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NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
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G |
Abcg8 |
ATP binding cassette subfamily G member 8 |
multiple interactions |
ISO |
Dehydroepiandrosterone results in increased activity of [ABCG5 protein binds to ABCG8 protein] |
CTD |
PMID:17055487 |
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NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912
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G |
Acox1 |
acyl-CoA oxidase 1 |
increases expression multiple interactions |
EXP ISO |
Dehydroepiandrosterone results in increased expression of ACOX1 mRNA Dehydroepiandrosterone results in increased expression of ACOX1 mRNA; Dehydroepiandrosterone results in increased expression of ACOX1 protein Dehydroepiandrosterone promotes the reaction [[ACOX1 protein results in increased metabolism of Palmitoyl Coenzyme A] which results in increased chemical synthesis of Hydrogen Peroxide] |
CTD |
PMID:10497882 PMID:16940010 |
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NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
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G |
Acsl1 |
acyl-CoA synthetase long-chain family member 1 |
increases expression |
EXP |
Dehydroepiandrosterone results in increased expression of ACSL1 mRNA |
CTD |
PMID:16940010 |
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NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
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G |
Adrb3 |
adrenoceptor beta 3 |
increases expression |
EXP |
Dehydroepiandrosterone results in increased expression of ADRB3 mRNA |
CTD |
PMID:12659879 |
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NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552
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G |
Agr2 |
anterior gradient 2, protein disulphide isomerase family member |
affects expression |
ISO |
Dehydroepiandrosterone affects the expression of AGR2 mRNA |
CTD |
PMID:17094431 |
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NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371
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G |
Akr1c3 |
aldo-keto reductase family 1, member C3 |
affects metabolic processing |
EXP |
AKR1C18 protein affects the metabolism of Dehydroepiandrosterone |
CTD |
PMID:15261307 |
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NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
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G |
Ar |
androgen receptor |
multiple interactions increases response to substance affects binding |
ISO EXP |
[AR protein mutant form results in increased susceptibility to Dehydroepiandrosterone] which results in increased activity of AR protein mutant form; [bicalutamide binds to and results in decreased activity of AR protein] inhibits the reaction [Dehydroepiandrosterone results in decreased expression of CYP1A2 mRNA]; AR protein affects the reaction [Dehydroepiandrosterone results in increased expression of RACK1 mRNA]; AR protein affects the reaction [Dehydroepiandrosterone results in increased expression of RACK1 protein]; Dehydroepiandrosterone binds to and results in decreased activity of AR protein; Dehydroepiandrosterone inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; Dehydroepiandrosterone promotes the reaction [AR protein binds to MIR21 promoter] Dehydroepiandrosterone binds to AR protein |
CTD |
PMID:14565775 PMID:15994348 PMID:23603339 PMID:25969534 PMID:27239218 PMID:27473015 PMID:33049310 More...
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Bad |
BCL2-associated agonist of cell death |
increases expression |
EXP |
Dehydroepiandrosterone results in increased expression of BAD mRNA |
CTD |
PMID:16940010 |
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NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
EXP |
Dehydroepiandrosterone results in increased expression of BAX protein |
CTD |
PMID:21062263 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases expression increases expression |
EXP |
Dexamethasone inhibits the reaction [Dehydroepiandrosterone results in increased expression of BCL2 protein]; Dihydrotestosterone inhibits the reaction [Dehydroepiandrosterone results in increased expression of BCL2 protein]; Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone results in increased expression of BCL2 protein] Dehydroepiandrosterone results in decreased expression of BCL2 protein |
CTD |
PMID:16407456 PMID:21062263 |
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NCBI chr13:22,689,783...22,853,920
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G |
Bcl2l1 |
Bcl2-like 1 |
increases expression multiple interactions |
EXP |
Dehydroepiandrosterone results in increased expression of BCL2L1 protein Dexamethasone inhibits the reaction [Dehydroepiandrosterone results in increased expression of BCL2L1 protein]; Dihydrotestosterone inhibits the reaction [Dehydroepiandrosterone results in increased expression of BCL2L1 protein]; Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone results in increased expression of BCL2L1 protein] |
CTD |
PMID:16407456 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Cat |
catalase |
increases activity |
EXP |
Dehydroepiandrosterone results in increased activity of CAT protein |
CTD |
PMID:8929588 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cdc20 |
cell division cycle 20 |
decreases expression |
EXP |
Dehydroepiandrosterone results in decreased expression of CDC20 mRNA |
CTD |
PMID:16940010 |
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NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO EXP |
Dehydroepiandrosterone results in increased expression of CDKN1A mRNA Dehydroepiandrosterone results in increased expression of CDKN1A protein |
CTD |
PMID:15752352 PMID:16457693 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn2a |
cyclin-dependent kinase inhibitor 2A |
increases expression |
EXP |
Dehydroepiandrosterone results in increased expression of CDKN2A protein |
CTD |
PMID:16457693 |
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NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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G |
Cyba |
cytochrome b-245 alpha chain |
multiple interactions increases expression |
EXP |
Metformin affects the reaction [Dehydroepiandrosterone results in increased expression of CYBA protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of CYBA mRNA]; Quercetin affects the reaction [Dehydroepiandrosterone results in increased expression of CYBA protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of CYBA mRNA] Dehydroepiandrosterone results in increased expression of CYBA mRNA; Dehydroepiandrosterone results in increased expression of CYBA protein |
CTD |
PMID:27634381 |
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NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
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G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
affects chemical synthesis multiple interactions affects metabolic processing decreases expression |
ISO EXP |
CYP17A1 protein affects the chemical synthesis of Dehydroepiandrosterone [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone; Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone]; Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone] CYP17A1 protein affects the metabolism of Dehydroepiandrosterone Dehydroepiandrosterone results in decreased expression of CYP17A1 mRNA |
CTD |
PMID:15261307 PMID:15562394 PMID:15625562 PMID:15666818 PMID:15934942 PMID:16030167 PMID:29100959 More...
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NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
increases metabolic processing multiple interactions decreases activity |
ISO |
CYP19A1 protein results in increased metabolism of Dehydroepiandrosterone Lipopolysaccharides inhibits the reaction [Dehydroepiandrosterone results in decreased activity of CYP19A1 protein] |
CTD |
PMID:10657851 PMID:16397352 |
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NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions increases degradation decreases stability |
ISO |
Dehydroepiandrosterone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased activity of CYP1A1 protein]; Dehydroepiandrosterone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 mRNA]; Dehydroepiandrosterone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Dehydroepiandrosterone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] Dehydroepiandrosterone results in increased degradation of CYP1A1 mRNA Dehydroepiandrosterone results in decreased stability of CYP1A1 mRNA |
CTD |
PMID:10575002 PMID:11597580 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions increases degradation decreases expression |
ISO |
[bicalutamide binds to and results in decreased activity of AR protein] inhibits the reaction [Dehydroepiandrosterone results in decreased expression of CYP1A2 mRNA]; bicalutamide inhibits the reaction [Dehydroepiandrosterone results in increased degradation of CYP1A2 mRNA]; Dehydroepiandrosterone inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA] |
CTD |
PMID:23603339 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
multiple interactions increases expression |
ISO |
Dehydroepiandrosterone inhibits the reaction [benz(a)anthracene promotes the reaction [CYP1B1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]]; Dehydroepiandrosterone inhibits the reaction [benz(a)anthracene results in increased expression of CYP1B1 mRNA]; Dehydroepiandrosterone inhibits the reaction [CYP1B1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]; Dehydroepiandrosterone inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CYP1B1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]] Dehydroepiandrosterone results in increased expression of CYP1B1 mRNA |
CTD |
PMID:10497882 |
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NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions increases hydroxylation |
ISO |
Dehydroepiandrosterone promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] CYP3A4 protein results in increased hydroxylation of Dehydroepiandrosterone |
CTD |
PMID:15845858 PMID:19299527 |
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NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp3a23-3a1 |
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 |
increases expression |
EXP |
Dehydroepiandrosterone results in increased expression of CYP3A23-3A1 mRNA |
CTD |
PMID:16940010 |
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NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
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G |
Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
increases hydroxylation |
ISO |
CYP3A5 protein results in increased hydroxylation of Dehydroepiandrosterone |
CTD |
PMID:15845858 |
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NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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G |
Cyp4a1 |
cytochrome P450, family 4, subfamily a, polypeptide 1 |
multiple interactions increases expression |
EXP |
Okadaic Acid inhibits the reaction [Dehydroepiandrosterone results in increased expression of CYP4A1 mRNA] |
CTD |
PMID:8700121 PMID:18079279 |
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NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
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G |
Cyp4a3 |
cytochrome P450, family 4, subfamily a, polypeptide 3 |
increases expression |
EXP |
Dehydroepiandrosterone results in increased expression of CYP4A3 mRNA |
CTD |
PMID:8700121 PMID:16940010 |
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NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463
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G |
Cyp7b1 |
cytochrome P450 family 7 subfamily B member 1 |
increases hydroxylation |
ISO |
CYP7B1 protein results in increased hydroxylation of Dehydroepiandrosterone |
CTD |
PMID:10588945 |
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NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698
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G |
Dbnl |
drebrin-like |
decreases expression |
EXP |
Dehydroepiandrosterone results in decreased expression of DBNL mRNA |
CTD |
PMID:16940010 |
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NCBI chr14:80,666,115...80,681,155
Ensembl chr14:80,666,124...80,681,155
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G |
Dhcr24 |
24-dehydrocholesterol reductase |
affects expression |
ISO |
Dehydroepiandrosterone affects the expression of DHCR24 mRNA |
CTD |
PMID:17094431 |
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NCBI chr 5:121,344,637...121,368,853
Ensembl chr 5:121,344,575...121,371,137
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G |
Dhrs11 |
dehydrogenase/reductase 11 |
increases reduction |
ISO |
DHRS11 protein results in increased reduction of Dehydroepiandrosterone |
CTD |
PMID:30926317 |
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NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295
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G |
Egfr |
epidermal growth factor receptor |
multiple interactions |
ISO |
EGFR protein promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA] |
CTD |
PMID:25969534 |
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NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Ehhadh |
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase |
increases expression |
EXP |
Dehydroepiandrosterone results in increased expression of EHHADH mRNA |
CTD |
PMID:16940010 |
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NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
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G |
Epo |
erythropoietin |
multiple interactions |
ISO |
[Dehydroepiandrosterone co-treated with Testosterone co-treated with GH1] results in decreased expression of EPO protein |
CTD |
PMID:15161484 |
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NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions increases phosphorylation increases expression affects binding |
ISO |
Dehydroepiandrosterone binds to and results in increased activity of ESR1 protein; ESR1 protein alternative form promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; GPER1 protein promotes the reaction [Dehydroepiandrosterone results in increased expression of ESR1 mRNA alternative form] Dehydroepiandrosterone results in increased phosphorylation of ESR1 protein Dehydroepiandrosterone results in increased expression of ESR1 mRNA alternative form; Dehydroepiandrosterone results in increased expression of ESR1 protein alternative form Dehydroepiandrosterone binds to ESR1 protein |
CTD |
PMID:15994348 PMID:19913605 PMID:25969534 PMID:33049310 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Esr2 |
estrogen receptor 2 |
multiple interactions affects binding |
ISO EXP |
Dehydroepiandrosterone binds to and results in increased activity of ESR2 protein Dehydroepiandrosterone binds to Esr2 protein |
CTD RGD |
PMID:15994348 PMID:33049310 PMID:9048584 |
RGD:8694130 |
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
Dehydroepiandrosterone promotes the reaction [FOS protein binds to MIR21 promoter] |
CTD |
PMID:25969534 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
G6pc1 |
glucose-6-phosphatase catalytic subunit 1 |
decreases expression |
ISO |
Dehydroepiandrosterone results in decreased expression of G6PC mRNA |
CTD |
PMID:11228057 |
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NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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G |
G6pd |
glucose-6-phosphate dehydrogenase |
multiple interactions |
ISO |
Dehydroepiandrosterone inhibits the reaction [ascorbate-2-phosphate results in increased activity of G6PD protein] |
CTD |
PMID:19746226 |
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NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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G |
Gh1 |
growth hormone 1 |
multiple interactions |
ISO |
[Dehydroepiandrosterone co-treated with Testosterone co-treated with GH1] results in decreased expression of EPO protein |
CTD |
PMID:15161484 |
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NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
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G |
Gpd1 |
glycerol-3-phosphate dehydrogenase 1 |
multiple interactions increases activity |
ISO |
benz(a)anthracene inhibits the reaction [Dehydroepiandrosterone results in increased activity of GPD1 protein]; Tetrachlorodibenzodioxin inhibits the reaction [Dehydroepiandrosterone results in increased activity of GPD1 protein] |
CTD |
PMID:10497882 |
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NCBI chr 7:130,842,526...130,851,530
Ensembl chr 7:130,844,138...130,851,529
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G |
Gper1 |
G protein-coupled estrogen receptor 1 |
multiple interactions increases expression |
ISO |
4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [Dehydroepiandrosterone results in increased expression of GPER1 mRNA]; GPER1 protein promotes the reaction [Dehydroepiandrosterone results in increased expression of ESR1 mRNA alternative form]; GPER1 protein promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA] Dehydroepiandrosterone results in increased expression of GPER1 mRNA; Dehydroepiandrosterone results in increased expression of GPER1 protein |
CTD |
PMID:25969534 |
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NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889
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G |
Hadhb |
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta |
increases expression |
EXP |
Dehydroepiandrosterone results in increased expression of HADHB mRNA |
CTD |
PMID:16940010 |
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NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
multiple interactions |
ISO |
Dehydroepiandrosterone inhibits the reaction [25-hydroxycholesterol results in decreased activity of HMGCR protein]; Dehydroepiandrosterone inhibits the reaction [27-hydroxycholesterol results in decreased activity of HMGCR protein] |
CTD |
PMID:9059514 |
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NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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G |
Hsd17b1 |
hydroxysteroid (17-beta) dehydrogenase 1 |
affects metabolic processing increases chemical synthesis |
ISO |
HSD17B1 protein affects the metabolism of Dehydroepiandrosterone HSD17B1 protein results in increased chemical synthesis of Dehydroepiandrosterone |
CTD |
PMID:16054388 |
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NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927
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G |
Hsd17b12 |
hydroxysteroid (17-beta) dehydrogenase 12 |
increases metabolic processing |
ISO |
HSD17B12 protein results in increased metabolism of Dehydroepiandrosterone |
CTD |
PMID:17641292 |
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NCBI chr 3:79,990,048...80,113,556
Ensembl chr 3:79,990,056...80,113,617
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G |
Hsd17b2 |
hydroxysteroid (17-beta) dehydrogenase 2 |
affects metabolic processing increases chemical synthesis |
ISO |
HSD17B2 protein affects the metabolism of Dehydroepiandrosterone HSD17B2 protein results in increased chemical synthesis of Dehydroepiandrosterone |
CTD |
PMID:16054388 |
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NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202
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G |
Hsd17b4 |
hydroxysteroid (17-beta) dehydrogenase 4 |
affects metabolic processing increases chemical synthesis |
ISO |
HSD17B4 protein affects the metabolism of Dehydroepiandrosterone HSD17B4 protein results in increased chemical synthesis of Dehydroepiandrosterone |
CTD |
PMID:16054388 |
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NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952
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G |
Hsd3b1 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
affects metabolic processing |
EXP ISO |
HSD3B1 protein affects the metabolism of Dehydroepiandrosterone |
CTD |
PMID:15261307 PMID:16054388 |
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NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
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G |
Igfbp3 |
insulin-like growth factor binding protein 3 |
decreases secretion |
ISO |
Dehydroepiandrosterone results in decreased secretion of IGFBP3 protein |
CTD |
PMID:16368782 |
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NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
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G |
Il1b |
interleukin 1 beta |
increases expression multiple interactions |
EXP |
Dehydroepiandrosterone results in increased expression of IL1B protein Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of IL1B protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of IL1B protein] |
CTD |
PMID:27634381 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
increases expression multiple interactions |
EXP |
Dehydroepiandrosterone results in increased expression of IL6 protein Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of IL6 protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of IL6 protein] |
CTD |
PMID:27634381 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Irs1 |
insulin receptor substrate 1 |
multiple interactions decreases phosphorylation |
EXP |
Metformin inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of IRS1 protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of IRS1 protein] |
CTD |
PMID:27634381 |
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NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases expression |
ISO |
Dehydroepiandrosterone promotes the reaction [JUN protein binds to MIR21 promoter] Dehydroepiandrosterone results in increased expression of JUN protein |
CTD |
PMID:25969534 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Kl |
Klotho |
multiple interactions |
ISO |
Dehydroepiandrosterone analog inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] |
CTD |
PMID:14701853 |
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NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080
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G |
Lep |
leptin |
decreases expression |
EXP |
Dehydroepiandrosterone results in decreased expression of LEP protein |
CTD |
PMID:12659879 |
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NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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Mapk6 |
mitogen-activated protein kinase 6 |
decreases expression |
EXP |
Dehydroepiandrosterone results in decreased expression of MAPK6 mRNA |
CTD |
PMID:16940010 |
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NCBI chr 8:76,146,650...76,169,767
Ensembl chr 8:76,146,690...76,169,720
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Mir200a |
microRNA 200a |
multiple interactions |
ISO |
[Pertussis Toxin co-treated with Dehydroepiandrosterone] results in increased expression of MIR200A mRNA; [wortmannin co-treated with Dehydroepiandrosterone] results in increased expression of MIR200A mRNA |
CTD |
PMID:25969534 |
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NCBI chr 5:166,648,494...166,648,582
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Mir21 |
microRNA 21 |
multiple interactions increases expression |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; AG 1879 inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; bicalutamide inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; Dactinomycin inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; Dehydroepiandrosterone promotes the reaction [AR protein binds to MIR21 promoter]; Dehydroepiandrosterone promotes the reaction [FOS protein binds to MIR21 promoter]; Dehydroepiandrosterone promotes the reaction [JUN protein binds to MIR21 promoter]; EGFR protein promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; ESR1 protein alternative form promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; GPER1 protein promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; methyl-beta-cyclodextrin inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; RTKI cpd inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; Wortmannin inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA] |
CTD |
PMID:25969534 |
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NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
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Mir22 |
microRNA 22 |
multiple interactions increases expression |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR22 mRNA]; [Dactinomycin co-treated with Dehydroepiandrosterone] results in increased expression of MIR22 mRNA; [Dehydroepiandrosterone results in increased expression of MIR22 mRNA] which results in decreased expression of PDCD4 protein; [wortmannin co-treated with Dehydroepiandrosterone] results in increased expression of MIR22 mRNA; Dactinomycin promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR22 mRNA] |
CTD |
PMID:25969534 |
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NCBI chr10:60,307,039...60,307,133
Ensembl chr10:60,307,039...60,307,133
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Mirlet7d |
microRNA let-7d |
increases expression |
ISO |
Dehydroepiandrosterone results in increased expression of MIRLET7D mRNA |
CTD |
PMID:25969534 |
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NCBI chr17:16,115,893...16,115,990
Ensembl chr17:16,115,893...16,115,990
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Mt-co1 |
mitochondrially encoded cytochrome c oxidase I |
increases expression |
EXP |
Dehydroepiandrosterone results in increased expression of COX1 mRNA |
CTD |
PMID:16940010 |
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NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
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Mt-co3 |
mitochondrially encoded cytochrome c oxidase III |
increases expression |
EXP |
Dehydroepiandrosterone results in increased expression of COX3 mRNA |
CTD |
PMID:16940010 |
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NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382
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Nppb |
natriuretic peptide B |
decreases expression |
ISO |
Dehydroepiandrosterone results in decreased expression of NPPB mRNA |
CTD |
PMID:15364798 |
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NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
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Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions |
ISO |
Dehydroepiandrosterone binds to and results in increased activity of NR1I2 protein |
CTD |
PMID:33049310 |
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
increases expression multiple interactions |
ISO |
Dehydroepiandrosterone results in increased expression of NR3C1 protein Flutamide inhibits the reaction [Dehydroepiandrosterone results in increased expression of NR3C1 protein] |
CTD |
PMID:27239218 |
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NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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Nts |
neurotensin |
affects expression |
ISO |
Dehydroepiandrosterone affects the expression of NTS mRNA |
CTD |
PMID:17094431 |
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NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423
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Olr1 |
oxidized low density lipoprotein receptor 1 |
increases expression multiple interactions |
EXP |
Dehydroepiandrosterone results in increased expression of OLR1 mRNA; Dehydroepiandrosterone results in increased expression of OLR1 protein Metformin affects the reaction [Dehydroepiandrosterone results in increased expression of OLR1 protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of OLR1 mRNA]; Quercetin affects the reaction [Dehydroepiandrosterone results in increased expression of OLR1 protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of OLR1 mRNA] |
CTD |
PMID:27634381 |
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NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523
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Orm1 |
orosomucoid 1 |
decreases expression |
EXP |
Dehydroepiandrosterone results in decreased expression of ORM1 mRNA |
CTD |
PMID:16940010 |
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NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154
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Pdcd4 |
programmed cell death 4 |
decreases expression multiple interactions |
ISO |
Dehydroepiandrosterone results in decreased expression of PDCD4 mRNA; Dehydroepiandrosterone results in decreased expression of PDCD4 protein [Dehydroepiandrosterone results in increased expression of MIR22 mRNA] which results in decreased expression of PDCD4 protein |
CTD |
PMID:25969534 |
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NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275
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Plcg2 |
phospholipase C, gamma 2 |
increases expression |
EXP |
Dehydroepiandrosterone results in increased expression of PLCG2 mRNA |
CTD |
PMID:16940010 |
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NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930
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Ppara |
peroxisome proliferator activated receptor alpha |
increases activity multiple interactions increases expression decreases phosphorylation |
ISO EXP |
Dehydroepiandrosterone results in increased activity of PPARA protein [Dehydroepiandrosterone results in increased expression of PPP2CA mRNA] which results in decreased phosphorylation of PPARA protein; Okadaic Acid inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of PPARA protein]; Okadaic Acid inhibits the reaction [Dehydroepiandrosterone results in increased activity of PPARA protein] Dehydroepiandrosterone results in increased expression of PPARA mRNA; Dehydroepiandrosterone results in increased expression of PPARA protein |
CTD |
PMID:18079279 |
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NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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Ppargc1a |
PPARG coactivator 1 alpha |
increases expression |
EXP |
Dehydroepiandrosterone results in increased expression of PPARGC1A mRNA |
CTD |
PMID:12659879 |
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NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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Ppp2ca |
protein phosphatase 2 catalytic subunit alpha |
multiple interactions increases expression |
EXP |
[Dehydroepiandrosterone results in increased expression of PPP2CA mRNA] which results in decreased phosphorylation of PPARA protein |
CTD |
PMID:18079279 |
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NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862
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Prl |
prolactin |
increases secretion |
ISO |
PRL protein results in increased secretion of Dehydroepiandrosterone |
CTD |
PMID:2948424 |
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NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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Psme1 |
proteasome activator subunit 1 |
decreases expression |
EXP |
Dehydroepiandrosterone results in decreased expression of PSME1 mRNA |
CTD |
PMID:16940010 |
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NCBI chr15:29,069,012...29,071,888
Ensembl chr15:29,068,729...29,071,890
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Rab38 |
RAB38, member RAS oncogene family |
decreases expression |
EXP |
Dehydroepiandrosterone results in decreased expression of RAB38 mRNA |
CTD |
PMID:16940010 |
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NCBI chr 1:142,182,566...142,262,923
Ensembl chr 1:142,182,556...142,262,924
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Rack1 |
receptor for activated C kinase 1 |
increases expression multiple interactions |
ISO |
Dehydroepiandrosterone results in increased expression of RACK1 mRNA; Dehydroepiandrosterone results in increased expression of RACK1 protein AR protein affects the reaction [Dehydroepiandrosterone results in increased expression of RACK1 mRNA]; AR protein affects the reaction [Dehydroepiandrosterone results in increased expression of RACK1 protein]; Flutamide inhibits the reaction [Dehydroepiandrosterone results in increased expression of RACK1 mRNA]; Flutamide inhibits the reaction [Dehydroepiandrosterone results in increased expression of RACK1 protein] |
CTD |
PMID:27239218 PMID:28412309 |
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NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975
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Rb1 |
RB transcriptional corepressor 1 |
increases expression multiple interactions |
EXP ISO |
Dehydroepiandrosterone results in increased expression of RB1 mRNA Dehydroepiandrosterone results in decreased expression of and results in decreased phosphorylation of RB1 protein |
CTD |
PMID:15752352 PMID:16940010 |
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NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
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Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions affects localization |
EXP |
Metformin inhibits the reaction [Dehydroepiandrosterone affects the localization of RELA protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone affects the localization of RELA protein] |
CTD |
PMID:27634381 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Rnpep |
arginyl aminopeptidase |
decreases expression |
EXP |
Dehydroepiandrosterone results in decreased expression of RNPEP mRNA |
CTD |
PMID:16940010 |
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NCBI chr13:46,699,458...46,717,829
Ensembl chr13:46,699,463...46,717,998
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Rpl41 |
ribosomal protein L41 |
decreases expression |
EXP |
Dehydroepiandrosterone results in decreased expression of RPL41 mRNA |
CTD |
PMID:16940010 |
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NCBI chr 7:977,885...978,965
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Sirt1 |
sirtuin 1 |
decreases expression affects expression |
ISO |
Dehydroepiandrosterone results in decreased expression of SIRT1 protein Dehydroepiandrosterone affects the expression of SIRT1 protein |
CTD |
PMID:20195491 |
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NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
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Slc22a8 |
solute carrier family 22 member 8 |
multiple interactions |
ISO |
Dehydroepiandrosterone inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate] |
CTD |
PMID:11306713 |
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NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
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Sod2 |
superoxide dismutase 2 |
decreases expression |
EXP |
Dehydroepiandrosterone results in decreased expression of SOD2 mRNA |
CTD |
PMID:16940010 |
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NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Src |
SRC proto-oncogene, non-receptor tyrosine kinase |
increases phosphorylation multiple interactions |
EXP ISO |
Dehydroepiandrosterone results in increased phosphorylation of SRC protein 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [Dehydroepiandrosterone results in increased phosphorylation of SRC protein] Dihydrotestosterone inhibits the reaction [Dehydroepiandrosterone results in increased phosphorylation of SRC protein]; Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone results in increased phosphorylation of SRC protein] |
CTD |
PMID:16407456 PMID:25969534 |
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NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
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Srd5a1 |
steroid 5 alpha-reductase 1 |
affects metabolic processing |
EXP |
SRD5A1 protein affects the metabolism of Dehydroepiandrosterone |
CTD |
PMID:15261307 |
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NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461
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Sts |
steroid sulfatase |
increases chemical synthesis |
ISO |
STS protein results in increased chemical synthesis of Dehydroepiandrosterone |
CTD |
PMID:16054388 |
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NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402
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Sult1e1 |
sulfotransferase family 1E member 1 |
increases sulfation |
ISO |
SULT1E1 protein results in increased sulfation of Dehydroepiandrosterone |
CTD |
PMID:8185618 |
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NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275
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Sult2a1 |
sulfotransferase family 2A member 1 |
multiple interactions increases metabolic processing increases sulfation |
ISO |
2,3'-dichlorobiphenyl metabolite inhibits the reaction [Dehydroepiandrosterone results in increased expression of SULT2A1 protein]; 2,3'-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; 2,3-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; 2,4'-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; 2,5-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein affects the metabolism of Dehydroepiandrosterone]; 2,5-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; 3',4'-dihydroxy-4-monochlorobiphenyl inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; 3,3'-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; 3,5-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; 4-chlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; Benzoquinones analog affects the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; Benzoquinones analog inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; Dehydroepiandrosterone inhibits the reaction [Benzoquinones analog inhibits the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT2A1 protein]]; Ethanol inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; Polychlorinated Biphenyls inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone] SULT2A1 protein results in increased metabolism of Dehydroepiandrosterone |
CTD |
PMID:10623578 PMID:10752640 PMID:14570759 PMID:17112228 PMID:19646966 PMID:20102295 PMID:21913674 PMID:24059442 PMID:24508592 PMID:30776358 More...
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NCBI chr 1:75,451,178...75,508,142
Ensembl chr 1:74,911,100...75,508,134
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Sult2b1 |
sulfotransferase family 2B member 1 |
increases sulfation |
ISO |
SULT2B1 protein results in increased sulfation of Dehydroepiandrosterone |
CTD |
PMID:9799594 |
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NCBI chr 1:96,200,155...96,261,295
Ensembl chr 1:96,200,156...96,261,295
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Tlr4 |
toll-like receptor 4 |
multiple interactions increases expression |
EXP |
Metformin affects the reaction [Dehydroepiandrosterone results in increased expression of TLR4 protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of TLR4 mRNA]; Quercetin affects the reaction [Dehydroepiandrosterone results in increased expression of TLR4 protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of TLR4 mRNA] Dehydroepiandrosterone results in increased expression of TLR4 mRNA; Dehydroepiandrosterone results in increased expression of TLR4 protein |
CTD |
PMID:27634381 |
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NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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Tnf |
tumor necrosis factor |
increases expression multiple interactions |
EXP ISO |
Dehydroepiandrosterone results in increased expression of TNF protein [Lipopolysaccharides co-treated with Dehydroepiandrosterone] results in increased secretion of TNF protein; Flutamide inhibits the reaction [[Lipopolysaccharides co-treated with Dehydroepiandrosterone] results in increased secretion of TNF protein] Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of TNF protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of TNF protein] |
CTD |
PMID:27239218 PMID:27634381 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Top2b |
DNA topoisomerase II beta |
decreases expression |
EXP |
Dehydroepiandrosterone results in decreased expression of TOP2B mRNA |
CTD |
PMID:16940010 |
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NCBI chr15:9,051,661...9,111,220
Ensembl chr15:9,051,341...9,112,085
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Tp53 |
tumor protein p53 |
increases expression |
ISO |
Dehydroepiandrosterone results in increased expression of TP53 mRNA |
CTD |
PMID:15752352 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Txnip |
thioredoxin interacting protein |
decreases expression |
ISO |
Dehydroepiandrosterone results in decreased expression of TXNIP protein |
CTD |
PMID:20195491 |
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NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
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Ucp1 |
uncoupling protein 1 |
increases expression decreases expression |
EXP |
Dehydroepiandrosterone results in increased expression of UCP1 mRNA; Dehydroepiandrosterone results in increased expression of UCP1 protein Dehydroepiandrosterone results in decreased expression of UCP1 mRNA |
CTD |
PMID:12659879 |
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NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852
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Ucp2 |
uncoupling protein 2 |
decreases expression |
EXP |
Dehydroepiandrosterone results in decreased expression of UCP2 mRNA |
CTD |
PMID:12659879 |
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NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
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Ucp3 |
uncoupling protein 3 |
increases expression decreases expression |
EXP |
Dehydroepiandrosterone results in increased expression of UCP3 mRNA Dehydroepiandrosterone results in decreased expression of UCP3 mRNA |
CTD |
PMID:12659879 |
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NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762
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Vmp1 |
vacuole membrane protein 1 |
multiple interactions increases expression |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA]; AG 1879 inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA]; Dactinomycin inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA]; methyl-beta-cyclodextrin inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA]; Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA] |
CTD |
PMID:25969534 |
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NCBI chr10:71,405,058...71,505,045
Ensembl chr10:71,405,452...71,505,007
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Xdh |
xanthine dehydrogenase |
decreases activity |
EXP |
Dehydroepiandrosterone results in decreased activity of XDH protein |
CTD |
PMID:8373410 |
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NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
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Abcb11 |
ATP binding cassette subfamily B member 11 |
decreases activity multiple interactions |
ISO |
Dehydroepiandrosterone Sulfate results in decreased activity of ABCB11 protein Dehydroepiandrosterone Sulfate inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] |
CTD |
PMID:24014644 |
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NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Acox1 |
acyl-CoA oxidase 1 |
increases expression multiple interactions |
ISO |
Dehydroepiandrosterone Sulfate results in increased expression of ACOX1 mRNA PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of ACOX1 mRNA] |
CTD |
PMID:8700121 |
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NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
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Bcl2 |
BCL2, apoptosis regulator |
increases expression multiple interactions |
EXP |
Dehydroepiandrosterone Sulfate results in increased expression of BCL2 protein Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone Sulfate results in increased expression of BCL2 protein] |
CTD |
PMID:16407456 |
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NCBI chr13:22,689,783...22,853,920
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Bcl2l1 |
Bcl2-like 1 |
increases expression multiple interactions |
EXP |
Dehydroepiandrosterone Sulfate results in increased expression of BCL2L1 protein Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone Sulfate results in increased expression of BCL2L1 protein] |
CTD |
PMID:16407456 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Cpt1a |
carnitine palmitoyltransferase 1A |
multiple interactions increases expression |
EXP |
[Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CPT1A protein Dehydroepiandrosterone Sulfate results in increased expression of CPT1A protein |
CTD |
PMID:25786523 |
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NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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Cyp2c11 |
cytochrome P450, subfamily 2, polypeptide 11 |
multiple interactions |
EXP |
[Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP2C11 protein |
CTD |
PMID:25786523 |
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NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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Cyp2c6v1 |
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 |
multiple interactions |
EXP |
[Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP2C6V1 protein |
CTD |
PMID:25786523 |
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NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions affects metabolic processing |
EXP ISO |
[Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP3A2 protein CYP3A4 protein affects the metabolism of Dehydroepiandrosterone Sulfate |
CTD |
PMID:2271712 PMID:25786523 |
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NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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Cyp4a1 |
cytochrome P450, family 4, subfamily a, polypeptide 1 |
increases expression multiple interactions |
EXP |
Dehydroepiandrosterone Sulfate results in increased expression of CYP4A1 mRNA; Dehydroepiandrosterone Sulfate results in increased expression of CYP4A1 protein [Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP4A1 protein |
CTD |
PMID:8700121 PMID:25786523 |
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NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
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Cyp4a3 |
cytochrome P450, family 4, subfamily a, polypeptide 3 |
increases expression |
EXP |
Dehydroepiandrosterone Sulfate results in increased expression of CYP4A3 mRNA |
CTD |
PMID:8700121 |
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NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463
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Ehhadh |
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase |
increases expression multiple interactions |
ISO |
Dehydroepiandrosterone Sulfate results in increased expression of EHHADH mRNA PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of EHHADH mRNA] |
CTD |
PMID:8700121 |
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NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
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Fabp1 |
fatty acid binding protein 1 |
increases expression multiple interactions |
ISO |
Dehydroepiandrosterone Sulfate results in increased expression of FABP1 mRNA PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of FABP1 mRNA] |
CTD |
PMID:8700121 |
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NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
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Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
[Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased expression of FOS protein |
CTD |
PMID:15196791 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Il1b |
interleukin 1 beta |
multiple interactions increases abundance |
ISO |
Dexamethasone inhibits the reaction [IL1B protein results in increased abundance of Dehydroepiandrosterone Sulfate] |
CTD |
PMID:12548226 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
[Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:15196791 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Nat1 |
N-acetyltransferase 1 |
multiple interactions |
ISO |
Dehydroepiandrosterone Sulfate inhibits the reaction [NAT1 protein results in increased acetylation of 4-Aminobenzoic Acid]; Dehydroepiandrosterone Sulfate promotes the reaction [NAT1 protein results in increased acetylation of 4-Aminobenzoic Acid] |
CTD |
PMID:11470991 |
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NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520
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Pomc |
proopiomelanocortin |
increases abundance |
ISO |
POMC results in increased abundance of Dehydroepiandrosterone Sulfate |
CTD |
PMID:2161262 |
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NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
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Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions increases response to substance |
ISO |
PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of ACOX1 mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of CYP4A1 mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of CYP4A3 mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of EHHADH mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of FABP1 mRNA] PPARA protein results in increased susceptibility to Dehydroepiandrosterone Sulfate |
CTD |
PMID:8700121 |
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NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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Prl |
prolactin |
increases abundance |
ISO |
PRL protein results in increased abundance of Dehydroepiandrosterone Sulfate |
CTD |
PMID:2943108 |
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NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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Sirt1 |
sirtuin 1 |
increases expression |
EXP |
Dehydroepiandrosterone Sulfate results in increased expression of SIRT1 protein |
CTD |
PMID:25786523 |
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NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
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Sirt6 |
sirtuin 6 |
increases expression |
EXP |
Dehydroepiandrosterone Sulfate results in increased expression of SIRT6 protein |
CTD |
PMID:25786523 |
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NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914
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Slc10a6 |
solute carrier family 10 member 6 |
increases transport |
ISO |
SLC10A6 protein results in increased transport of Dehydroepiandrosterone Sulfate |
CTD |
PMID:23562556 |
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NCBI chr14:6,080,716...6,102,037
Ensembl chr14:6,080,717...6,103,037
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Slc22a12 |
solute carrier family 22 member 12 |
multiple interactions |
ISO |
Potassium promotes the reaction [SLC22A12 protein results in increased uptake of Dehydroepiandrosterone Sulfate] |
CTD |
PMID:15284287 |
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NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555
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Slc22a25 |
solute carrier family 22, member 25 |
increases uptake multiple interactions |
EXP ISO |
SLC22A9 protein results in increased uptake of Dehydroepiandrosterone Sulfate Dehydroepiandrosterone Sulfate inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate] |
CTD |
PMID:17132213 PMID:18441515 |
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NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085
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Slc22a7 |
solute carrier family 22 member 7 |
increases transport |
ISO |
SLC22A7 protein results in increased transport of Dehydroepiandrosterone Sulfate |
CTD |
PMID:15901346 |
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NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
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Slc22a8 |
solute carrier family 22 member 8 |
affects transport increases uptake |
ISO |
SLC22A8 protein affects the transport of Dehydroepiandrosterone Sulfate SLC22A8 protein results in increased uptake of Dehydroepiandrosterone Sulfate |
CTD |
PMID:11306713 PMID:16098483 PMID:17255469 |
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NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
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Slco1b2 |
solute carrier organic anion transporter family member 1B2 |
multiple interactions |
ISO |
Dehydroepiandrosterone Sulfate inhibits the reaction [SLCO1B3 protein results in increased susceptibility to cyanoginosin LR]; Dehydroepiandrosterone Sulfate inhibits the reaction [SLCO1B3 protein results in increased susceptibility to Okadaic Acid] |
CTD |
PMID:26134461 |
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NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
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Src |
SRC proto-oncogene, non-receptor tyrosine kinase |
increases phosphorylation |
EXP |
Dehydroepiandrosterone Sulfate results in increased phosphorylation of SRC protein |
CTD |
PMID:16407456 |
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NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
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Sts |
steroid sulfatase |
affects metabolic processing |
ISO |
STS protein affects the metabolism of Dehydroepiandrosterone Sulfate |
CTD |
PMID:16054388 |
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NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402
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