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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dehydroepiandrosterone
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Accession:CHEBI:28689 term browser browse the term
Definition:An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
Synonyms:related_synonym: 3-BETA-HYDROXY-5-ANDROSTEN-17-ONE;   3beta-hydroxyandrost-5-en-17-one;   DHA;   DHEA;   Dehydroisoandrosterone;   Formula=C19H28O2;   InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1;   InChIKey=FMGSKLZLMKYGDP-USOAJAOKSA-N;   Intrarosa;   Prasterone;   SMILES=[H][C@@]12CC=C3C[C@@H](O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)C(=O)CC[C@@]21[H]
 alt_id: CHEBI:11911;   CHEBI:1723;   CHEBI:20246;   CHEBI:40738;   CHEBI:86953
 xref: CAS:53-43-0;   DrugBank:DB01708;   Drug_Central:795;   HMDB:HMDB0000077;   KEGG:C01227;   KEGG:D08409;   LIPID_MAPS_instance:LMST02020021
 xref_mesh: MESH:D003687
 xref: MetaCyc:3-BETA-HYDROXYANDROST-5-EN-17-ONE;   PDBeChem:AND;   PMID:14662261;   PMID:18634257;   PMID:24256992;   PMID:24424045;   Reaxys:2058110;   Wikipedia:Dehydroepiandrosterone


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dehydroepiandrosterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg5 ATP binding cassette subfamily G member 5 multiple interactions ISO Dehydroepiandrosterone results in increased activity of [ABCG5 protein binds to ABCG8 protein] CTD PMID:17055487 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563 		JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 multiple interactions ISO Dehydroepiandrosterone results in increased activity of [ABCG5 protein binds to ABCG8 protein] CTD PMID:17055487 NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912 		JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression
multiple interactions		 EXP
ISO		 Dehydroepiandrosterone results in increased expression of ACOX1 mRNA
Dehydroepiandrosterone results in increased expression of ACOX1 mRNA; Dehydroepiandrosterone results in increased expression of ACOX1 protein
Dehydroepiandrosterone promotes the reaction [[ACOX1 protein results in increased metabolism of Palmitoyl Coenzyme A] which results in increased chemical synthesis of Hydrogen Peroxide]		 CTD PMID:10497882 PMID:16940010 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases expression EXP Dehydroepiandrosterone results in increased expression of ACSL1 mRNA CTD PMID:16940010 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541 		JBrowse link
G Adrb3 adrenoceptor beta 3 increases expression EXP Dehydroepiandrosterone results in increased expression of ADRB3 mRNA CTD PMID:12659879 NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552 		JBrowse link
G Agr2 anterior gradient 2, protein disulphide isomerase family member affects expression ISO Dehydroepiandrosterone affects the expression of AGR2 mRNA CTD PMID:17094431 NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 affects metabolic processing EXP AKR1C18 protein affects the metabolism of Dehydroepiandrosterone CTD PMID:15261307 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Ar androgen receptor multiple interactions
increases response to substance
affects binding		 ISO
EXP		 [AR protein mutant form results in increased susceptibility to Dehydroepiandrosterone] which results in increased activity of AR protein mutant form; [bicalutamide binds to and results in decreased activity of AR protein] inhibits the reaction [Dehydroepiandrosterone results in decreased expression of CYP1A2 mRNA]; AR protein affects the reaction [Dehydroepiandrosterone results in increased expression of RACK1 mRNA]; AR protein affects the reaction [Dehydroepiandrosterone results in increased expression of RACK1 protein]; Dehydroepiandrosterone binds to and results in decreased activity of AR protein; Dehydroepiandrosterone inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; Dehydroepiandrosterone promotes the reaction [AR protein binds to MIR21 promoter]
Dehydroepiandrosterone binds to AR protein		 CTD PMID:14565775 PMID:15994348 PMID:23603339 PMID:25969534 PMID:27239218 More... NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression EXP Dehydroepiandrosterone results in increased expression of BAD mRNA CTD PMID:16940010 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP Dehydroepiandrosterone results in increased expression of BAX protein CTD PMID:21062263 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
increases expression		 EXP Dexamethasone inhibits the reaction [Dehydroepiandrosterone results in increased expression of BCL2 protein]; Dihydrotestosterone inhibits the reaction [Dehydroepiandrosterone results in increased expression of BCL2 protein]; Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone results in increased expression of BCL2 protein]
Dehydroepiandrosterone results in decreased expression of BCL2 protein		 CTD PMID:16407456 PMID:21062263 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression
multiple interactions		 EXP Dehydroepiandrosterone results in increased expression of BCL2L1 protein
Dexamethasone inhibits the reaction [Dehydroepiandrosterone results in increased expression of BCL2L1 protein]; Dihydrotestosterone inhibits the reaction [Dehydroepiandrosterone results in increased expression of BCL2L1 protein]; Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone results in increased expression of BCL2L1 protein]		 CTD PMID:16407456 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Cat catalase increases activity EXP Dehydroepiandrosterone results in increased activity of CAT protein CTD PMID:8929588 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cdc20 cell division cycle 20 decreases expression EXP Dehydroepiandrosterone results in decreased expression of CDC20 mRNA CTD PMID:16940010 NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO
EXP		 Dehydroepiandrosterone results in increased expression of CDKN1A mRNA
Dehydroepiandrosterone results in increased expression of CDKN1A protein		 CTD PMID:15752352 PMID:16457693 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression EXP Dehydroepiandrosterone results in increased expression of CDKN2A protein CTD PMID:16457693 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions
increases expression		 EXP Metformin affects the reaction [Dehydroepiandrosterone results in increased expression of CYBA protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of CYBA mRNA]; Quercetin affects the reaction [Dehydroepiandrosterone results in increased expression of CYBA protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of CYBA mRNA]
Dehydroepiandrosterone results in increased expression of CYBA mRNA; Dehydroepiandrosterone results in increased expression of CYBA protein		 CTD PMID:27634381 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 affects chemical synthesis
multiple interactions
affects metabolic processing
decreases expression		 ISO
EXP		 CYP17A1 protein affects the chemical synthesis of Dehydroepiandrosterone
[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone; Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone]; Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone]
CYP17A1 protein affects the metabolism of Dehydroepiandrosterone
Dehydroepiandrosterone results in decreased expression of CYP17A1 mRNA		 CTD PMID:15261307 PMID:15562394 PMID:15625562 PMID:15666818 PMID:15934942 More... NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases metabolic processing
multiple interactions
decreases activity		 ISO CYP19A1 protein results in increased metabolism of Dehydroepiandrosterone
Lipopolysaccharides inhibits the reaction [Dehydroepiandrosterone results in decreased activity of CYP19A1 protein]		 CTD PMID:10657851 PMID:16397352 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases degradation
decreases stability		 ISO Dehydroepiandrosterone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased activity of CYP1A1 protein]; Dehydroepiandrosterone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 mRNA]; Dehydroepiandrosterone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Dehydroepiandrosterone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Dehydroepiandrosterone results in increased degradation of CYP1A1 mRNA
Dehydroepiandrosterone results in decreased stability of CYP1A1 mRNA		 CTD PMID:10575002 PMID:11597580 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases degradation
decreases expression		 ISO [bicalutamide binds to and results in decreased activity of AR protein] inhibits the reaction [Dehydroepiandrosterone results in decreased expression of CYP1A2 mRNA]; bicalutamide inhibits the reaction [Dehydroepiandrosterone results in increased degradation of CYP1A2 mRNA]; Dehydroepiandrosterone inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA] CTD PMID:23603339 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases expression		 ISO Dehydroepiandrosterone inhibits the reaction [benz(a)anthracene promotes the reaction [CYP1B1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]]; Dehydroepiandrosterone inhibits the reaction [benz(a)anthracene results in increased expression of CYP1B1 mRNA]; Dehydroepiandrosterone inhibits the reaction [CYP1B1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]; Dehydroepiandrosterone inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CYP1B1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]]
Dehydroepiandrosterone results in increased expression of CYP1B1 mRNA		 CTD PMID:10497882 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases hydroxylation		 ISO Dehydroepiandrosterone promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]
CYP3A4 protein results in increased hydroxylation of Dehydroepiandrosterone		 CTD PMID:15845858 PMID:19299527 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Dehydroepiandrosterone results in increased expression of CYP3A23-3A1 mRNA CTD PMID:16940010 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases hydroxylation ISO CYP3A5 protein results in increased hydroxylation of Dehydroepiandrosterone CTD PMID:15845858 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 multiple interactions
increases expression		 EXP Okadaic Acid inhibits the reaction [Dehydroepiandrosterone results in increased expression of CYP4A1 mRNA] CTD PMID:8700121 PMID:18079279 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464 		JBrowse link
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 increases expression EXP Dehydroepiandrosterone results in increased expression of CYP4A3 mRNA CTD PMID:8700121 PMID:16940010 NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463 		JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 increases hydroxylation ISO CYP7B1 protein results in increased hydroxylation of Dehydroepiandrosterone CTD PMID:10588945 NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698 		JBrowse link
G Dbnl drebrin-like decreases expression EXP Dehydroepiandrosterone results in decreased expression of DBNL mRNA CTD PMID:16940010 NCBI chr14:80,666,115...80,681,155
Ensembl chr14:80,666,124...80,681,155 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase affects expression ISO Dehydroepiandrosterone affects the expression of DHCR24 mRNA CTD PMID:17094431 NCBI chr 5:121,344,637...121,368,853
Ensembl chr 5:121,344,575...121,371,137 		JBrowse link
G Dhrs11 dehydrogenase/reductase 11 increases reduction ISO DHRS11 protein results in increased reduction of Dehydroepiandrosterone CTD PMID:30926317 NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO EGFR protein promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA] CTD PMID:25969534 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression EXP Dehydroepiandrosterone results in increased expression of EHHADH mRNA CTD PMID:16940010 NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188 		JBrowse link
G Epo erythropoietin multiple interactions ISO [Dehydroepiandrosterone co-treated with Testosterone co-treated with GH1] results in decreased expression of EPO protein CTD PMID:15161484 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases phosphorylation
increases expression
affects binding		 ISO Dehydroepiandrosterone binds to and results in increased activity of ESR1 protein; ESR1 protein alternative form promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; GPER1 protein promotes the reaction [Dehydroepiandrosterone results in increased expression of ESR1 mRNA alternative form]
Dehydroepiandrosterone results in increased phosphorylation of ESR1 protein
Dehydroepiandrosterone results in increased expression of ESR1 mRNA alternative form; Dehydroepiandrosterone results in increased expression of ESR1 protein alternative form
Dehydroepiandrosterone binds to ESR1 protein		 CTD PMID:15994348 PMID:19913605 PMID:25969534 PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects binding		 ISO
EXP		 Dehydroepiandrosterone binds to and results in increased activity of ESR2 protein
Dehydroepiandrosterone binds to Esr2 protein		 CTD
RGD		 PMID:15994348 PMID:33049310 PMID:9048584 RGD:8694130 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Dehydroepiandrosterone promotes the reaction [FOS protein binds to MIR21 promoter] CTD PMID:25969534 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO Dehydroepiandrosterone results in decreased expression of G6PC mRNA CTD PMID:11228057 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions ISO Dehydroepiandrosterone inhibits the reaction [ascorbate-2-phosphate results in increased activity of G6PD protein] CTD PMID:19746226 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gh1 growth hormone 1 multiple interactions ISO [Dehydroepiandrosterone co-treated with Testosterone co-treated with GH1] results in decreased expression of EPO protein CTD PMID:15161484 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078 		JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 multiple interactions
increases activity		 ISO benz(a)anthracene inhibits the reaction [Dehydroepiandrosterone results in increased activity of GPD1 protein]; Tetrachlorodibenzodioxin inhibits the reaction [Dehydroepiandrosterone results in increased activity of GPD1 protein] CTD PMID:10497882 NCBI chr 7:130,842,526...130,851,530
Ensembl chr 7:130,844,138...130,851,529 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 multiple interactions
increases expression		 ISO 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [Dehydroepiandrosterone results in increased expression of GPER1 mRNA]; GPER1 protein promotes the reaction [Dehydroepiandrosterone results in increased expression of ESR1 mRNA alternative form]; GPER1 protein promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]
Dehydroepiandrosterone results in increased expression of GPER1 mRNA; Dehydroepiandrosterone results in increased expression of GPER1 protein		 CTD PMID:25969534 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889 		JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta increases expression EXP Dehydroepiandrosterone results in increased expression of HADHB mRNA CTD PMID:16940010 NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO Dehydroepiandrosterone inhibits the reaction [25-hydroxycholesterol results in decreased activity of HMGCR protein]; Dehydroepiandrosterone inhibits the reaction [27-hydroxycholesterol results in decreased activity of HMGCR protein] CTD PMID:9059514 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 affects metabolic processing
increases chemical synthesis		 ISO HSD17B1 protein affects the metabolism of Dehydroepiandrosterone
HSD17B1 protein results in increased chemical synthesis of Dehydroepiandrosterone		 CTD PMID:16054388 NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927 		JBrowse link
G Hsd17b12 hydroxysteroid (17-beta) dehydrogenase 12 increases metabolic processing ISO HSD17B12 protein results in increased metabolism of Dehydroepiandrosterone CTD PMID:17641292 NCBI chr 3:79,990,048...80,113,556
Ensembl chr 3:79,990,056...80,113,617 		JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 affects metabolic processing
increases chemical synthesis		 ISO HSD17B2 protein affects the metabolism of Dehydroepiandrosterone
HSD17B2 protein results in increased chemical synthesis of Dehydroepiandrosterone		 CTD PMID:16054388 NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202 		JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 affects metabolic processing
increases chemical synthesis		 ISO HSD17B4 protein affects the metabolism of Dehydroepiandrosterone
HSD17B4 protein results in increased chemical synthesis of Dehydroepiandrosterone		 CTD PMID:16054388 NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 affects metabolic processing EXP
ISO		 HSD3B1 protein affects the metabolism of Dehydroepiandrosterone CTD PMID:15261307 PMID:16054388 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 decreases secretion ISO Dehydroepiandrosterone results in decreased secretion of IGFBP3 protein CTD PMID:16368782 NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 EXP Dehydroepiandrosterone results in increased expression of IL1B protein
Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of IL1B protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of IL1B protein]		 CTD PMID:27634381 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 EXP Dehydroepiandrosterone results in increased expression of IL6 protein
Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of IL6 protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of IL6 protein]		 CTD PMID:27634381 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions
decreases phosphorylation		 EXP Metformin inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of IRS1 protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of IRS1 protein] CTD PMID:27634381 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 ISO Dehydroepiandrosterone promotes the reaction [JUN protein binds to MIR21 promoter]
Dehydroepiandrosterone results in increased expression of JUN protein		 CTD PMID:25969534 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kl Klotho multiple interactions ISO Dehydroepiandrosterone analog inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] CTD PMID:14701853 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080 		JBrowse link
G Lep leptin decreases expression EXP Dehydroepiandrosterone results in decreased expression of LEP protein CTD PMID:12659879 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Mapk6 mitogen-activated protein kinase 6 decreases expression EXP Dehydroepiandrosterone results in decreased expression of MAPK6 mRNA CTD PMID:16940010 NCBI chr 8:76,146,650...76,169,767
Ensembl chr 8:76,146,690...76,169,720 		JBrowse link
G Mir200a microRNA 200a multiple interactions ISO [Pertussis Toxin co-treated with Dehydroepiandrosterone] results in increased expression of MIR200A mRNA; [wortmannin co-treated with Dehydroepiandrosterone] results in increased expression of MIR200A mRNA CTD PMID:25969534 NCBI chr 5:166,648,494...166,648,582 JBrowse link
G Mir21 microRNA 21 multiple interactions
increases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; AG 1879 inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; bicalutamide inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; Dactinomycin inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; Dehydroepiandrosterone promotes the reaction [AR protein binds to MIR21 promoter]; Dehydroepiandrosterone promotes the reaction [FOS protein binds to MIR21 promoter]; Dehydroepiandrosterone promotes the reaction [JUN protein binds to MIR21 promoter]; EGFR protein promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; ESR1 protein alternative form promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; GPER1 protein promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; methyl-beta-cyclodextrin inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; RTKI cpd inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; Wortmannin inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA] CTD PMID:25969534 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mir22 microRNA 22 multiple interactions
increases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR22 mRNA]; [Dactinomycin co-treated with Dehydroepiandrosterone] results in increased expression of MIR22 mRNA; [Dehydroepiandrosterone results in increased expression of MIR22 mRNA] which results in decreased expression of PDCD4 protein; [wortmannin co-treated with Dehydroepiandrosterone] results in increased expression of MIR22 mRNA; Dactinomycin promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR22 mRNA] CTD PMID:25969534 NCBI chr10:60,307,039...60,307,133
Ensembl chr10:60,307,039...60,307,133 		JBrowse link
G Mirlet7d microRNA let-7d increases expression ISO Dehydroepiandrosterone results in increased expression of MIRLET7D mRNA CTD PMID:25969534 NCBI chr17:16,115,893...16,115,990
Ensembl chr17:16,115,893...16,115,990 		JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I increases expression EXP Dehydroepiandrosterone results in increased expression of COX1 mRNA CTD PMID:16940010 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867 		JBrowse link
G Mt-co3 mitochondrially encoded cytochrome c oxidase III increases expression EXP Dehydroepiandrosterone results in increased expression of COX3 mRNA CTD PMID:16940010 NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382 		JBrowse link
G Nppb natriuretic peptide B decreases expression ISO Dehydroepiandrosterone results in decreased expression of NPPB mRNA CTD PMID:15364798 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Dehydroepiandrosterone binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases expression
multiple interactions		 ISO Dehydroepiandrosterone results in increased expression of NR3C1 protein
Flutamide inhibits the reaction [Dehydroepiandrosterone results in increased expression of NR3C1 protein]		 CTD PMID:27239218 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Nts neurotensin affects expression ISO Dehydroepiandrosterone affects the expression of NTS mRNA CTD PMID:17094431 NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423 		JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 increases expression
multiple interactions		 EXP Dehydroepiandrosterone results in increased expression of OLR1 mRNA; Dehydroepiandrosterone results in increased expression of OLR1 protein
Metformin affects the reaction [Dehydroepiandrosterone results in increased expression of OLR1 protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of OLR1 mRNA]; Quercetin affects the reaction [Dehydroepiandrosterone results in increased expression of OLR1 protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of OLR1 mRNA]		 CTD PMID:27634381 NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523 		JBrowse link
G Orm1 orosomucoid 1 decreases expression EXP Dehydroepiandrosterone results in decreased expression of ORM1 mRNA CTD PMID:16940010 NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154 		JBrowse link
G Pdcd4 programmed cell death 4 decreases expression
multiple interactions		 ISO Dehydroepiandrosterone results in decreased expression of PDCD4 mRNA; Dehydroepiandrosterone results in decreased expression of PDCD4 protein
[Dehydroepiandrosterone results in increased expression of MIR22 mRNA] which results in decreased expression of PDCD4 protein		 CTD PMID:25969534 NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275 		JBrowse link
G Plcg2 phospholipase C, gamma 2 increases expression EXP Dehydroepiandrosterone results in increased expression of PLCG2 mRNA CTD PMID:16940010 NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases activity
multiple interactions
increases expression
decreases phosphorylation		 ISO
EXP		 Dehydroepiandrosterone results in increased activity of PPARA protein
[Dehydroepiandrosterone results in increased expression of PPP2CA mRNA] which results in decreased phosphorylation of PPARA protein; Okadaic Acid inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of PPARA protein]; Okadaic Acid inhibits the reaction [Dehydroepiandrosterone results in increased activity of PPARA protein]
Dehydroepiandrosterone results in increased expression of PPARA mRNA; Dehydroepiandrosterone results in increased expression of PPARA protein		 CTD PMID:18079279 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression EXP Dehydroepiandrosterone results in increased expression of PPARGC1A mRNA CTD PMID:12659879 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha multiple interactions
increases expression		 EXP [Dehydroepiandrosterone results in increased expression of PPP2CA mRNA] which results in decreased phosphorylation of PPARA protein CTD PMID:18079279 NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862 		JBrowse link
G Prl prolactin increases secretion ISO PRL protein results in increased secretion of Dehydroepiandrosterone CTD PMID:2948424 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Psme1 proteasome activator subunit 1 decreases expression EXP Dehydroepiandrosterone results in decreased expression of PSME1 mRNA CTD PMID:16940010 NCBI chr15:29,069,012...29,071,888
Ensembl chr15:29,068,729...29,071,890 		JBrowse link
G Rab38 RAB38, member RAS oncogene family decreases expression EXP Dehydroepiandrosterone results in decreased expression of RAB38 mRNA CTD PMID:16940010 NCBI chr 1:142,182,566...142,262,923
Ensembl chr 1:142,182,556...142,262,924 		JBrowse link
G Rack1 receptor for activated C kinase 1 increases expression
multiple interactions		 ISO Dehydroepiandrosterone results in increased expression of RACK1 mRNA; Dehydroepiandrosterone results in increased expression of RACK1 protein
AR protein affects the reaction [Dehydroepiandrosterone results in increased expression of RACK1 mRNA]; AR protein affects the reaction [Dehydroepiandrosterone results in increased expression of RACK1 protein]; Flutamide inhibits the reaction [Dehydroepiandrosterone results in increased expression of RACK1 mRNA]; Flutamide inhibits the reaction [Dehydroepiandrosterone results in increased expression of RACK1 protein]		 CTD PMID:27239218 PMID:28412309 NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975 		JBrowse link
G Rb1 RB transcriptional corepressor 1 increases expression
multiple interactions		 EXP
ISO		 Dehydroepiandrosterone results in increased expression of RB1 mRNA
Dehydroepiandrosterone results in decreased expression of and results in decreased phosphorylation of RB1 protein		 CTD PMID:15752352 PMID:16940010 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization		 EXP Metformin inhibits the reaction [Dehydroepiandrosterone affects the localization of RELA protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone affects the localization of RELA protein] CTD PMID:27634381 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rnpep arginyl aminopeptidase decreases expression EXP Dehydroepiandrosterone results in decreased expression of RNPEP mRNA CTD PMID:16940010 NCBI chr13:46,699,458...46,717,829
Ensembl chr13:46,699,463...46,717,998 		JBrowse link
G Rpl41 ribosomal protein L41 decreases expression EXP Dehydroepiandrosterone results in decreased expression of RPL41 mRNA CTD PMID:16940010 NCBI chr 7:977,885...978,965 JBrowse link
G Sirt1 sirtuin 1 decreases expression
affects expression		 ISO Dehydroepiandrosterone results in decreased expression of SIRT1 protein
Dehydroepiandrosterone affects the expression of SIRT1 protein		 CTD PMID:20195491 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions ISO Dehydroepiandrosterone inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate] CTD PMID:11306713 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Sod2 superoxide dismutase 2 decreases expression EXP Dehydroepiandrosterone results in decreased expression of SOD2 mRNA CTD PMID:16940010 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase increases phosphorylation
multiple interactions		 EXP
ISO		 Dehydroepiandrosterone results in increased phosphorylation of SRC protein
4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [Dehydroepiandrosterone results in increased phosphorylation of SRC protein]
Dihydrotestosterone inhibits the reaction [Dehydroepiandrosterone results in increased phosphorylation of SRC protein]; Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone results in increased phosphorylation of SRC protein]		 CTD PMID:16407456 PMID:25969534 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 affects metabolic processing EXP SRD5A1 protein affects the metabolism of Dehydroepiandrosterone CTD PMID:15261307 NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461 		JBrowse link
G Sts steroid sulfatase increases chemical synthesis ISO STS protein results in increased chemical synthesis of Dehydroepiandrosterone CTD PMID:16054388 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402 		JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 increases sulfation ISO SULT1E1 protein results in increased sulfation of Dehydroepiandrosterone CTD PMID:8185618 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 multiple interactions
increases metabolic processing
increases sulfation		 ISO 2,3'-dichlorobiphenyl metabolite inhibits the reaction [Dehydroepiandrosterone results in increased expression of SULT2A1 protein]; 2,3'-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; 2,3-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; 2,4'-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; 2,5-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein affects the metabolism of Dehydroepiandrosterone]; 2,5-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; 3',4'-dihydroxy-4-monochlorobiphenyl inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; 3,3'-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; 3,5-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; 4-chlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; Benzoquinones analog affects the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; Benzoquinones analog inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; Dehydroepiandrosterone inhibits the reaction [Benzoquinones analog inhibits the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT2A1 protein]]; Ethanol inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; Polychlorinated Biphenyls inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]
SULT2A1 protein results in increased metabolism of Dehydroepiandrosterone		 CTD PMID:10623578 PMID:10752640 PMID:14570759 PMID:17112228 PMID:19646966 More... NCBI chr 1:75,451,178...75,508,142
Ensembl chr 1:74,911,100...75,508,134 		JBrowse link
G Sult2b1 sulfotransferase family 2B member 1 increases sulfation ISO SULT2B1 protein results in increased sulfation of Dehydroepiandrosterone CTD PMID:9799594 NCBI chr 1:96,200,155...96,261,295
Ensembl chr 1:96,200,156...96,261,295 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions
increases expression		 EXP Metformin affects the reaction [Dehydroepiandrosterone results in increased expression of TLR4 protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of TLR4 mRNA]; Quercetin affects the reaction [Dehydroepiandrosterone results in increased expression of TLR4 protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of TLR4 mRNA]
Dehydroepiandrosterone results in increased expression of TLR4 mRNA; Dehydroepiandrosterone results in increased expression of TLR4 protein		 CTD PMID:27634381 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 EXP
ISO		 Dehydroepiandrosterone results in increased expression of TNF protein
[Lipopolysaccharides co-treated with Dehydroepiandrosterone] results in increased secretion of TNF protein; Flutamide inhibits the reaction [[Lipopolysaccharides co-treated with Dehydroepiandrosterone] results in increased secretion of TNF protein]
Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of TNF protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of TNF protein]		 CTD PMID:27239218 PMID:27634381 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Top2b DNA topoisomerase II beta decreases expression EXP Dehydroepiandrosterone results in decreased expression of TOP2B mRNA CTD PMID:16940010 NCBI chr15:9,051,661...9,111,220
Ensembl chr15:9,051,341...9,112,085 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO Dehydroepiandrosterone results in increased expression of TP53 mRNA CTD PMID:15752352 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Txnip thioredoxin interacting protein decreases expression ISO Dehydroepiandrosterone results in decreased expression of TXNIP protein CTD PMID:20195491 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886 		JBrowse link
G Ucp1 uncoupling protein 1 increases expression
decreases expression		 EXP Dehydroepiandrosterone results in increased expression of UCP1 mRNA; Dehydroepiandrosterone results in increased expression of UCP1 protein
Dehydroepiandrosterone results in decreased expression of UCP1 mRNA		 CTD PMID:12659879 NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852 		JBrowse link
G Ucp2 uncoupling protein 2 decreases expression EXP Dehydroepiandrosterone results in decreased expression of UCP2 mRNA CTD PMID:12659879 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611 		JBrowse link
G Ucp3 uncoupling protein 3 increases expression
decreases expression		 EXP Dehydroepiandrosterone results in increased expression of UCP3 mRNA
Dehydroepiandrosterone results in decreased expression of UCP3 mRNA		 CTD PMID:12659879 NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762 		JBrowse link
G Vmp1 vacuole membrane protein 1 multiple interactions
increases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA]; AG 1879 inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA]; Dactinomycin inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA]; methyl-beta-cyclodextrin inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA]; Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA] CTD PMID:25969534 NCBI chr10:71,405,058...71,505,045
Ensembl chr10:71,405,452...71,505,007 		JBrowse link
G Xdh xanthine dehydrogenase decreases activity EXP Dehydroepiandrosterone results in decreased activity of XDH protein CTD PMID:8373410 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
dehydroepiandrosterone sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions		 ISO Dehydroepiandrosterone Sulfate results in decreased activity of ABCB11 protein
Dehydroepiandrosterone Sulfate inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]		 CTD PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression
multiple interactions		 ISO Dehydroepiandrosterone Sulfate results in increased expression of ACOX1 mRNA
PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of ACOX1 mRNA]		 CTD PMID:8700121 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions		 EXP Dehydroepiandrosterone Sulfate results in increased expression of BCL2 protein
Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone Sulfate results in increased expression of BCL2 protein]		 CTD PMID:16407456 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression
multiple interactions		 EXP Dehydroepiandrosterone Sulfate results in increased expression of BCL2L1 protein
Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone Sulfate results in increased expression of BCL2L1 protein]		 CTD PMID:16407456 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions
increases expression		 EXP [Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CPT1A protein
Dehydroepiandrosterone Sulfate results in increased expression of CPT1A protein		 CTD PMID:25786523 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions EXP [Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP2C11 protein CTD PMID:25786523 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions EXP [Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP2C6V1 protein CTD PMID:25786523 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
affects metabolic processing		 EXP
ISO		 [Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP3A2 protein
CYP3A4 protein affects the metabolism of Dehydroepiandrosterone Sulfate		 CTD PMID:2271712 PMID:25786523 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases expression
multiple interactions		 EXP Dehydroepiandrosterone Sulfate results in increased expression of CYP4A1 mRNA; Dehydroepiandrosterone Sulfate results in increased expression of CYP4A1 protein
[Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP4A1 protein		 CTD PMID:8700121 PMID:25786523 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464 		JBrowse link
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 increases expression EXP Dehydroepiandrosterone Sulfate results in increased expression of CYP4A3 mRNA CTD PMID:8700121 NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463 		JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression
multiple interactions		 ISO Dehydroepiandrosterone Sulfate results in increased expression of EHHADH mRNA
PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of EHHADH mRNA]		 CTD PMID:8700121 NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188 		JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression
multiple interactions		 ISO Dehydroepiandrosterone Sulfate results in increased expression of FABP1 mRNA
PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of FABP1 mRNA]		 CTD PMID:8700121 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased expression of FOS protein CTD PMID:15196791 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases abundance		 ISO Dexamethasone inhibits the reaction [IL1B protein results in increased abundance of Dehydroepiandrosterone Sulfate] CTD PMID:12548226 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased phosphorylation of MAPK1 protein CTD PMID:15196791 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Nat1 N-acetyltransferase 1 multiple interactions ISO Dehydroepiandrosterone Sulfate inhibits the reaction [NAT1 protein results in increased acetylation of 4-Aminobenzoic Acid]; Dehydroepiandrosterone Sulfate promotes the reaction [NAT1 protein results in increased acetylation of 4-Aminobenzoic Acid] CTD PMID:11470991 NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Pomc proopiomelanocortin increases abundance ISO POMC results in increased abundance of Dehydroepiandrosterone Sulfate CTD PMID:2161262 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases response to substance		 ISO PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of ACOX1 mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of CYP4A1 mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of CYP4A3 mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of EHHADH mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of FABP1 mRNA]
PPARA protein results in increased susceptibility to Dehydroepiandrosterone Sulfate		 CTD PMID:8700121 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Prl prolactin increases abundance ISO PRL protein results in increased abundance of Dehydroepiandrosterone Sulfate CTD PMID:2943108 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Sirt1 sirtuin 1 increases expression EXP Dehydroepiandrosterone Sulfate results in increased expression of SIRT1 protein CTD PMID:25786523 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sirt6 sirtuin 6 increases expression EXP Dehydroepiandrosterone Sulfate results in increased expression of SIRT6 protein CTD PMID:25786523 NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914 		JBrowse link
G Slc10a6 solute carrier family 10 member 6 increases transport ISO SLC10A6 protein results in increased transport of Dehydroepiandrosterone Sulfate CTD PMID:23562556 NCBI chr14:6,080,716...6,102,037
Ensembl chr14:6,080,717...6,103,037 		JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions ISO Potassium promotes the reaction [SLC22A12 protein results in increased uptake of Dehydroepiandrosterone Sulfate] CTD PMID:15284287 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555 		JBrowse link
G Slc22a25 solute carrier family 22, member 25 increases uptake
multiple interactions		 EXP
ISO		 SLC22A9 protein results in increased uptake of Dehydroepiandrosterone Sulfate
Dehydroepiandrosterone Sulfate inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]		 CTD PMID:17132213 PMID:18441515 NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 increases transport ISO SLC22A7 protein results in increased transport of Dehydroepiandrosterone Sulfate CTD PMID:15901346 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 affects transport
increases uptake		 ISO SLC22A8 protein affects the transport of Dehydroepiandrosterone Sulfate
SLC22A8 protein results in increased uptake of Dehydroepiandrosterone Sulfate		 CTD PMID:11306713 PMID:16098483 PMID:17255469 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO Dehydroepiandrosterone Sulfate inhibits the reaction [SLCO1B3 protein results in increased susceptibility to cyanoginosin LR]; Dehydroepiandrosterone Sulfate inhibits the reaction [SLCO1B3 protein results in increased susceptibility to Okadaic Acid] CTD PMID:26134461 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase increases phosphorylation EXP Dehydroepiandrosterone Sulfate results in increased phosphorylation of SRC protein CTD PMID:16407456 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Sts steroid sulfatase affects metabolic processing ISO STS protein affects the metabolism of Dehydroepiandrosterone Sulfate CTD PMID:16054388 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      biological role 20007
        molecular messenger 18621
          hormone 18475
            sex hormone 18249
              androgen 5687
                dehydroepiandrosterone 115
                  16alpha-hydroxydehydroepiandrosterone 3-sulfate 0
                  3beta-(2-diethylaminoethoxy)androst-5-en-17-one 0
                  7-ketodehydroepiandrosterone 0
                  7alpha-hydroxydehydroepiandrosterone 0
                  7beta-hydroxydehydroepiandrosterone 0
                  dehydroepiandrosterone 3-beta-D-glucoside 0
                  dehydroepiandrosterone 7-O-(carboxymethyl)oxime 0
                  dehydroepiandrosterone sulfate 29
                  dehydroisoandrosterone 3-glucuronide 0
                  prasterone sodium sulfate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic molecule 19822
                              organic cyclic compound 19575
                                organic polycyclic compound 17176
                                  steroid 14380
                                    hydroxy steroid 14096
                                      3-hydroxy steroid 12143
                                        3beta-hydroxy steroid 2018
                                          3beta-hydroxy-Delta(5)-steroid 1848
                                            dehydroepiandrosterone 115
                                              16alpha-hydroxydehydroepiandrosterone 3-sulfate 0
                                              3beta-(2-diethylaminoethoxy)androst-5-en-17-one 0
                                              7-ketodehydroepiandrosterone 0
                                              7alpha-hydroxydehydroepiandrosterone 0
                                              7beta-hydroxydehydroepiandrosterone 0
                                              dehydroepiandrosterone 3-beta-D-glucoside 0
                                              dehydroepiandrosterone 7-O-(carboxymethyl)oxime 0
                                              dehydroepiandrosterone sulfate 29
                                              dehydroisoandrosterone 3-glucuronide 0
                                              prasterone sodium sulfate 0
paths to the root