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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:kynurenine
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Accession:CHEBI:28683 term browser browse the term
Definition:A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Synonyms:related_synonym: 2-amino-4-(2-aminophenyl)-4-oxobutanoic acid;   Formula=C10H12N2O3;   InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15);   InChIKey=YGPSJZOEDVAXAB-UHFFFAOYSA-N;   SMILES=NC(CC(=O)c1ccccc1N)C(O)=O
 alt_id: CHEBI:24992;   CHEBI:6148
 xref: CAS:343-65-7;   KEGG:C01718
 xref_mesh: MESH:D007737
 xref: PMID:14651996;   PMID:16139256;   PMID:17386621;   PMID:19027117;   PMID:22770225;   Reaxys:2697333
 cyclic_relationship: is_conjugate_acid_of CHEBI:67008


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kynurenine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions
increases expression
ISO 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [[Kynurenine co-treated with [Medroxyprogesterone Acetate co-treated with Cyclic AMP]] results in increased expression of AHR mRNA]; [Kynurenine co-treated with [Medroxyprogesterone Acetate co-treated with Cyclic AMP]] results in increased expression of AHR mRNA
Kynurenine results in increased expression of AHR mRNA
CTD PMID:32781018 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO Kynurenine inhibits the reaction [IDO2 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP1A1 mRNA]]
Kynurenine results in increased expression of CYP1A1 mRNA
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [[Kynurenine co-treated with [Medroxyprogesterone Acetate co-treated with Cyclic AMP]] results in increased expression of CYP1A1 mRNA]; [Kynurenine co-treated with [Medroxyprogesterone Acetate co-treated with Cyclic AMP]] results in increased expression of CYP1A1 mRNA
CTD PMID:32289347 PMID:32781018 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases expression
ISO 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [[Kynurenine co-treated with [Medroxyprogesterone Acetate co-treated with Cyclic AMP]] results in increased expression of CYP1B1 mRNA]; [Kynurenine co-treated with [Medroxyprogesterone Acetate co-treated with Cyclic AMP]] results in increased expression of CYP1B1 mRNA
Kynurenine results in increased expression of CYP1B1 mRNA
CTD PMID:32781018 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 decreases abundance ISO IDO1 gene mutant form results in decreased abundance of Kynurenine CTD PMID:32871117 NCBI chr16:67,430,684...67,442,459
Ensembl chr16:67,430,578...67,442,730
JBrowse link
G Ido2 indoleamine 2,3-dioxygenase 2 increases chemical synthesis
multiple interactions
ISO IDO2 protein results in increased chemical synthesis of Kynurenine
IDO2 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased abundance of Kynurenine]; Kynurenine inhibits the reaction [IDO2 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP1A1 mRNA]]
CTD PMID:32289347 NCBI chr16:67,459,158...67,498,052
Ensembl chr16:67,459,190...67,496,324
JBrowse link
G Ifng interferon gamma multiple interactions
increases chemical synthesis
ISO 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [[IFNG protein co-treated with [Medroxyprogesterone Acetate co-treated with Cyclic AMP]] results in increased abundance of Kynurenine]; [IFNG protein co-treated with [Medroxyprogesterone Acetate co-treated with Cyclic AMP]] results in increased abundance of Kynurenine; salinomycin inhibits the reaction [IFNG protein results in increased chemical synthesis of Kynurenine] CTD PMID:32781018 PMID:32822738 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 multiple interactions
increases expression
ISO 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Kynurenine promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of IGFBP1 mRNA]]; Kynurenine promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of IGFBP1 mRNA]
Kynurenine results in increased expression of IGFBP1 mRNA
CTD PMID:32781018 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
JBrowse link
G Kmo kynurenine 3-monooxygenase multiple interactions EXP [KMO protein results in increased hydroxylation of Kynurenine] which results in increased chemical synthesis of 3-hydroxykynurenine CTD PMID:32243540 NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881
JBrowse link
G Kynu kynureninase increases expression ISO Kynurenine results in increased expression of KYNU mRNA CTD PMID:32781018 NCBI chr 3:27,778,646...27,929,470
Ensembl chr 3:27,778,772...27,929,488
JBrowse link
G Prl prolactin increases expression
multiple interactions
ISO Kynurenine results in increased expression of PRL mRNA
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Kynurenine promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of PRL mRNA]]; Kynurenine promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of PRL mRNA]
CTD PMID:32781018 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase decreases abundance ISO TDO2 gene mutant form results in decreased abundance of Kynurenine CTD PMID:32871117 NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511
JBrowse link
3-hydroxykynurenine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kmo kynurenine 3-monooxygenase multiple interactions EXP [KMO protein results in increased hydroxylation of Kynurenine] which results in increased chemical synthesis of 3-hydroxykynurenine CTD PMID:32243540 NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      application 19471
        refrigerant 17691
          ammonia 17278
            organic amino compound 17278
              aromatic amine 13701
                anilines 12359
                  substituted aniline 11852
                    kynurenine 11
                      D-kynurenine 0
                      L-kynurenine + 0
                      N-acetylkynurenine 0
                      N-formylkynurenine + 0
                      hydroxykynurenine + 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    main group molecular entity 19708
                      s-block molecular entity 19493
                        hydrogen molecular entity 19488
                          hydrides 18845
                            inorganic hydride 17691
                              pnictogen hydride 17672
                                nitrogen hydride 17545
                                  azane 17279
                                    ammonia 17278
                                      organic amino compound 17278
                                        aromatic amine 13701
                                          anilines 12359
                                            substituted aniline 11852
                                              kynurenine 11
                                                D-kynurenine 0
                                                L-kynurenine + 0
                                                N-acetylkynurenine 0
                                                N-formylkynurenine + 0
                                                hydroxykynurenine + 1
paths to the root