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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:kynurenine
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Accession:CHEBI:28683 term browser browse the term
Definition:A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Synonyms:related_synonym: 2-amino-4-(2-aminophenyl)-4-oxobutanoic acid;   Formula=C10H12N2O3;   InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15);   InChIKey=YGPSJZOEDVAXAB-UHFFFAOYSA-N;   SMILES=NC(CC(=O)c1ccccc1N)C(O)=O
 alt_id: CHEBI:24992;   CHEBI:6148
 xref: CAS:343-65-7;   KEGG:C01718
 xref_mesh: MESH:D007737
 xref: PMID:14651996;   PMID:16139256;   PMID:17386621;   PMID:19027117;   PMID:22770225;   Reaxys:2697333
 cyclic_relationship: is_conjugate_acid_of CHEBI:67008


show annotations for term's descendants           Sort by:
 
kynurenine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Kynurenine inhibits the reaction [IDO2 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP1A1 mRNA]] CTD PMID:32289347 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Ido2 indoleamine 2,3-dioxygenase 2 increases chemical synthesis
multiple interactions
ISO IDO2 protein results in increased chemical synthesis of Kynurenine
IDO2 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased abundance of Kynurenine]; Kynurenine inhibits the reaction [IDO2 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP1A1 mRNA]]
CTD PMID:32289347 NCBI chr16:72,232,852...72,291,227
Ensembl chr16:72,268,943...72,289,156
JBrowse link
G Kmo kynurenine 3-monooxygenase multiple interactions EXP [KMO protein results in increased hydroxylation of Kynurenine] which results in increased chemical synthesis of 3-hydroxykynurenine CTD PMID:32243540 NCBI chr13:93,684,324...93,715,378
Ensembl chr13:93,684,437...93,716,227
JBrowse link
3-hydroxykynurenine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kmo kynurenine 3-monooxygenase multiple interactions EXP [KMO protein results in increased hydroxylation of Kynurenine] which results in increased chemical synthesis of 3-hydroxykynurenine CTD PMID:32243540 NCBI chr13:93,684,324...93,715,378
Ensembl chr13:93,684,437...93,716,227
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        refrigerant 17418
          ammonia 16939
            organic amino compound 16938
              aromatic amine 13616
                anilines 12327
                  substituted aniline 11823
                    kynurenine 3
                      D-kynurenine 0
                      L-kynurenine + 0
                      N-acetylkynurenine 0
                      N-formylkynurenine + 0
                      hydroxykynurenine + 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            inorganic hydride 17409
                              pnictogen hydride 17381
                                nitrogen hydride 17223
                                  azane 16940
                                    ammonia 16939
                                      organic amino compound 16938
                                        aromatic amine 13616
                                          anilines 12327
                                            substituted aniline 11823
                                              kynurenine 3
                                                D-kynurenine 0
                                                L-kynurenine + 0
                                                N-acetylkynurenine 0
                                                N-formylkynurenine + 0
                                                hydroxykynurenine + 1
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