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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:gamma-linolenic acid
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Accession:CHEBI:28661 term browser browse the term
Definition:A C18, omega-6 acid fatty acid comprising a linolenic acid having cis- double bonds at positions 6, 9 and 12.
Synonyms:exact_synonym: (6Z,9Z,12Z)-octadeca-6,9,12-trienoic acid
 related_synonym: (6,9,12)-linolenic acid;   (Z,Z,Z)-6,9,12-octadecatrienoic acid;   18:3 (n-6);   6,9,12-Octadecatrienoic acid;   6-cis,9-cis,12-cis-octadecatrienoic acid;   6Z,9Z,12Z-Octadecatrienoic acid;   C18:3 (n-6);   C18:3, n-6,9,12 all-cis;   Formula=C18H30O2;   GLA;   InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/b7-6-,10-9-,13-12-;   InChIKey=VZCCETWTMQHEPK-QNEBEIHSSA-N;   Octadeca-6,9,12-triensaeure;   SMILES=CCCCC\\C=C/C\\C=C/C\\C=C/CCCCC(O)=O;   all-cis-6,9,12-octadecatrienoic acid;   cis-Delta(6,9,12)-octadecatrienoic acid;   gamma-Linolensaeure;   gamoleic acid;   gamolenic acid
 alt_id: CHEBI:10573;   CHEBI:24197
 xref: Beilstein:1712253;   CAS:506-26-3;   Drug_Central:1276;   HMDB:HMDB0003073;   KEGG:C06426;   KEGG:D07213;   KNApSAcK:C00001226;   LIPID_MAPS_instance:LMFA01030141
 xref_mesh: MESH:D017965
 xref: MetaCyc:CPD-8117;   PMID:11385052;   PMID:24435467;   PMID:9732298;   Reaxys:1712253;   Wikipedia:Gamma-Linolenic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:32391



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gamma-linolenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 increases expression ISO gamma-Linolenic Acid results in increased expression of AKR1C1 mRNA CTD PMID:20664735 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
JBrowse link
G Apoh apolipoprotein H decreases expression ISO gamma-Linolenic Acid results in decreased expression of APOH mRNA CTD PMID:20664735 NCBI chr10:93,342,435...93,356,334
Ensembl chr10:93,310,977...93,356,329
JBrowse link
G Ar androgen receptor multiple interactions ISO gamma-Linolenic Acid inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO gamma-Linolenic Acid results in increased expression of ASAH1 mRNA CTD PMID:20664735 NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233
JBrowse link
G Casp3 caspase 3 increases activity ISO gamma-Linolenic Acid results in increased activity of CASP3 protein CTD PMID:16857180 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO gamma-Linolenic Acid results in decreased expression of CCNA2 protein CTD PMID:15318936 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO gamma-Linolenic Acid results in decreased expression of CCNE1 protein CTD PMID:15318936 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO gamma-Linolenic Acid results in decreased expression of CDK1 protein CTD PMID:15318936 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cldn5 claudin 5 multiple interactions ISO [gamma-Linolenic Acid co-treated with Iodine co-treated with Selenium] results in increased expression of and results in increased localization of CLDN5 protein; [gamma-Linolenic Acid co-treated with Iodine] results in increased expression of and results in increased localization of CLDN5 protein; [Selenium co-treated with gamma-Linolenic Acid] results in increased expression of and results in increased localization of CLDN5 protein; gamma-Linolenic Acid results in increased expression of and results in increased localization of CLDN5 protein CTD PMID:16514648 NCBI chr11:82,212,822...82,214,248 JBrowse link
G Clta clathrin, light chain A increases expression ISO gamma-Linolenic Acid results in increased expression of CLTA mRNA CTD PMID:20664735 NCBI chr 5:58,244,253...58,263,480
Ensembl chr 5:58,245,442...58,263,472
JBrowse link
G Fth1 ferritin heavy chain 1 increases expression ISO gamma-Linolenic Acid results in increased expression of FTH1 mRNA CTD PMID:20664735 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases activity
increases expression
ISO gamma-Linolenic Acid results in increased activity of GCLC protein
gamma-Linolenic Acid results in increased expression of GCLC mRNA
CTD PMID:17092368 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Grk5 G protein-coupled receptor kinase 5 increases expression ISO gamma-Linolenic Acid results in increased expression of GRK5 mRNA CTD PMID:20664735 NCBI chr 1:260,028,269...260,223,699
Ensembl chr 1:260,028,242...260,218,701
JBrowse link
G Hexb hexosaminidase subunit beta increases expression ISO gamma-Linolenic Acid results in increased expression of HEXB mRNA CTD PMID:20664735 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO gamma-Linolenic Acid results in increased expression of HMOX1 mRNA; gamma-Linolenic Acid results in increased expression of HMOX1 protein CTD PMID:17092368 PMID:20664735 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il2 interleukin 2 affects expression ISO gamma-Linolenic Acid affects the expression of IL2 protein CTD PMID:9415022 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit decreases expression ISO gamma-Linolenic Acid results in decreased expression of JUNB protein CTD PMID:15318936 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Kynu kynureninase decreases expression ISO gamma-Linolenic Acid results in decreased expression of KYNU mRNA CTD PMID:20664735 NCBI chr 3:27,778,646...27,929,470
Ensembl chr 3:27,778,772...27,929,488
JBrowse link
G LOC103690190 histone H2A type 1-E decreases expression ISO gamma-Linolenic Acid results in decreased expression of H2AC6 mRNA CTD PMID:20664735 NCBI chr17:42,707,863...42,708,420 JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases expression ISO gamma-Linolenic Acid results in decreased expression of MAPK3 protein CTD PMID:15318936 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp11 matrix metallopeptidase 11 decreases expression ISO gamma-Linolenic Acid results in decreased expression of MMP11 mRNA CTD PMID:20664735 NCBI chr20:12,730,846...12,739,629
Ensembl chr20:12,730,836...12,739,628
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO gamma-Linolenic Acid results in decreased expression of MYC protein CTD PMID:15318936 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Ocln occludin multiple interactions ISO [gamma-Linolenic Acid co-treated with Iodine co-treated with Selenium] results in increased expression of and results in increased localization of OCLN protein; [gamma-Linolenic Acid co-treated with Iodine] results in increased expression of and results in increased localization of OCLN protein; [Selenium co-treated with gamma-Linolenic Acid] results in increased expression of and results in increased localization of OCLN protein; gamma-Linolenic Acid results in increased expression of and results in increased localization of OCLN protein CTD PMID:16514648 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO gamma-Linolenic Acid results in increased cleavage of PARP1 protein CTD PMID:10403056 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO gamma-Linolenic Acid results in decreased expression of PCNA mRNA CTD PMID:20664735 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pdlim1 PDZ and LIM domain 1 decreases expression ISO gamma-Linolenic Acid results in decreased expression of PDLIM1 mRNA CTD PMID:20664735 NCBI chr 1:239,042,372...239,091,074
Ensembl chr 1:239,042,385...239,091,076
JBrowse link
G Plin2 perilipin 2 increases expression ISO gamma-Linolenic Acid results in increased expression of PLIN2 mRNA CTD PMID:20664735 NCBI chr 5:101,156,643...101,211,738
Ensembl chr 5:101,154,411...101,242,319
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO gamma-Linolenic Acid binds to and results in increased activity of PPARA protein CTD PMID:10403814 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO gamma-Linolenic Acid binds to and results in increased activity of PPARG protein CTD PMID:15318936 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ptgr1 prostaglandin reductase 1 increases expression ISO gamma-Linolenic Acid results in increased expression of PTGR1 mRNA CTD PMID:20664735 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO gamma-Linolenic Acid results in increased expression of PTGS2 mRNA CTD PMID:17092368 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Skp2 S-phase kinase associated protein 2 decreases expression ISO gamma-Linolenic Acid results in decreased expression of SKP2 mRNA CTD PMID:20664735 NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338
JBrowse link
G Slc3a2 solute carrier family 3 member 2 increases expression ISO gamma-Linolenic Acid results in increased expression of SLC3A2 mRNA CTD PMID:20664735 NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931
JBrowse link
G St13 ST13, Hsp70 interacting protein increases expression ISO gamma-Linolenic Acid results in increased expression of ST13 mRNA CTD PMID:20664735 NCBI chr 7:112,891,007...112,925,727 JBrowse link
G Tff3 trefoil factor 3 decreases expression ISO gamma-Linolenic Acid results in decreased expression of TFF3 mRNA CTD PMID:20664735 NCBI chr20:9,193,259...9,197,969
Ensembl chr20:9,193,262...9,198,054
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO [gamma-Linolenic Acid co-treated with Iodine co-treated with Selenium] results in increased expression of and results in increased localization of TJP1 protein CTD PMID:16514648 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tnf tumor necrosis factor decreases expression ISO gamma-Linolenic Acid results in decreased expression of TNF protein CTD PMID:9415022 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP gamma-Linolenic Acid inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein] CTD PMID:17038422 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Txn1 thioredoxin 1 increases expression ISO gamma-Linolenic Acid results in increased expression of TXN mRNA CTD PMID:20664735 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO gamma-Linolenic Acid results in increased expression of TXNRD1 mRNA CTD PMID:20664735 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      biological role 19746
        biochemical role 19361
          metabolite 19338
            eukaryotic metabolite 19026
              plant metabolite 17452
                gamma-linolenic acid 40
                  1-(gamma-linolenoyl)-2-oleoyl-sn-glycero-3-phosphate 0
                  1-(gamma-linolenoyl)-sn-glycero-3-phosphate 0
                  1-[(6Z,9Z,12Z)-octadecatrienoyl]-2-[(15Z)-tetracosenoyl]-sn-glycero-3-phosphocholine 0
                  1-[(6Z,9Z,12Z)-octadecatrienoyl]-2-[(9Z)-octadecenoyl]-snglycero-3-phosphocholine 0
                  1-[(9Z)-octadecenoyl]-2-[(6Z,9Z,12Z)-octadecatrienoyl]-sn-glycero-3-phosphocholine 0
                  1-hexadecyl-2-[(6Z,9Z,12Z)-octadecatrienoyl]-sn-glycero-3-phosphocholine 0
                  1-octadecanoyl-2-[(6Z,9Z,12Z)-octadecatrienoyl]-sn-glycero-3-phosphocholine 0
                  1-palmitoyl-2-[(6Z,9Z,12Z)-octadecatrienoyl]-sn-glycero-3-phosphocholine 0
                  1-tetracosyl-2-[(6Z,9Z,12Z)-octadecatrienoyl]-sn-glycero-3-phosphocholine 0
                  10(R)-HPO(6,8,12)TrE 0
                  10-HPO(6,8,12)TrE + 0
                  cholesteryl gamma-linolenate 0
                  gamma-linolenoyl bioconjugate + 0
                  gamma-linolenoyl group 0
                  gamma-linolenoyl-CoA 0
                  gamma-linolenoyl-containing glycerolipid + 0
                  methyl gamma-linolenate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      carbon group element atom 19614
                        carbon atom 19604
                          organic molecular entity 19604
                            organic group 18713
                              organic divalent group 18697
                                organodiyl group 18697
                                  carbonyl group 18646
                                    carbonyl compound 18646
                                      carboxylic acid 18341
                                        monocarboxylic acid 17618
                                          fatty acid 16009
                                            unsaturated fatty acid 957
                                              polyunsaturated fatty acid 692
                                                trienoic fatty acid 121
                                                  fatty acid 18:3 107
                                                    octadecatrienoic acid 107
                                                      linolenic acid 104
                                                        gamma-linolenic acid 40
                                                          1-(gamma-linolenoyl)-2-oleoyl-sn-glycero-3-phosphate 0
                                                          1-(gamma-linolenoyl)-sn-glycero-3-phosphate 0
                                                          1-[(6Z,9Z,12Z)-octadecatrienoyl]-2-[(15Z)-tetracosenoyl]-sn-glycero-3-phosphocholine 0
                                                          1-[(6Z,9Z,12Z)-octadecatrienoyl]-2-[(9Z)-octadecenoyl]-snglycero-3-phosphocholine 0
                                                          1-[(9Z)-octadecenoyl]-2-[(6Z,9Z,12Z)-octadecatrienoyl]-sn-glycero-3-phosphocholine 0
                                                          1-hexadecyl-2-[(6Z,9Z,12Z)-octadecatrienoyl]-sn-glycero-3-phosphocholine 0
                                                          1-octadecanoyl-2-[(6Z,9Z,12Z)-octadecatrienoyl]-sn-glycero-3-phosphocholine 0
                                                          1-palmitoyl-2-[(6Z,9Z,12Z)-octadecatrienoyl]-sn-glycero-3-phosphocholine 0
                                                          1-tetracosyl-2-[(6Z,9Z,12Z)-octadecatrienoyl]-sn-glycero-3-phosphocholine 0
                                                          10(R)-HPO(6,8,12)TrE 0
                                                          10-HPO(6,8,12)TrE + 0
                                                          cholesteryl gamma-linolenate 0
                                                          gamma-linolenoyl bioconjugate + 0
                                                          gamma-linolenoyl group 0
                                                          gamma-linolenoyl-CoA 0
                                                          gamma-linolenoyl-containing glycerolipid + 0
                                                          methyl gamma-linolenate 0
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