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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3-phenylpropionic acid
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Accession:CHEBI:28631 term browser browse the term
Definition:A monocarboxylic acid that is propionic acid substituted at position 3 by a phenyl group.
Synonyms:related_synonym: 3-Phenyl-propionic acid;   3-Phenylpropanoic acid;   3-Phenylpropionsaeure;   3PP;   Formula=C9H10O2;   HYDROCINNAMIC ACID;   Hydrozimtsaeure;   InChI=1S/C9H10O2/c10-9(11)7-6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,11);   InChIKey=XMIIGOLPHOKFCH-UHFFFAOYSA-N;   Phenylpropanoate;   SMILES=OC(=O)CCc1ccccc1;   benzenepropanoic acid;   benzenepropionic acid;   benzylacetic acid;   beta-phenylpropionic acid;   dihydrocinnamic acid
 alt_id: CHEBI:26002;   CHEBI:26005;   CHEBI:43112;   CHEBI:8103
 xref: Beilstein:907515;   CAS:501-52-0;   DrugBank:DB02024;   ECMDB:ECMDB00764;   Gmelin:102198;   HMDB:HMDB0000764;   KEGG:C05629
 xref_mesh: MESH:C035253
 xref: MetaCyc:3-PHENYLPROPIONATE;   PDBeChem:HCI;   PMID:18062653;   PMID:20972783;   PMID:23470767;   PMID:24216280;   Reaxys:907515;   Wikipedia:Phenylpropanoic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:51057



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3-phenylpropionic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO 3-phenylpropionic acid results in decreased expression of PTGS2 protein CTD PMID:16177193 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Tyr tyrosinase increases oxidation
multiple interactions
ISO TYR protein results in increased oxidation of 3-phenylpropionic acid
[TYR protein results in increased oxidation of 3-phenylpropionic acid] which results in decreased abundance of Glutathione
CTD PMID:20685355 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of 3-phenylpropionic acid CTD PMID:15117964 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases glucuronidation EXP UGT2B1 protein results in increased glucuronidation of 3-phenylpropionic acid CTD PMID:8302279 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
JBrowse link
3-(3,4-dihydroxyphenyl)propanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ide insulin degrading enzyme multiple interactions ISO 3,4-dihydroxyphenylpropionic acid binds to and affects the activity of IDE protein CTD PMID:23146021 NCBI chr 1:235,002,984...235,102,448
Ensembl chr 1:234,995,351...235,102,440
JBrowse link
G Tyr tyrosinase increases oxidation
multiple interactions
ISO TYR protein results in increased oxidation of 3,4-dihydroxyphenylpropionic acid
[TYR protein results in increased oxidation of 3,4-dihydroxyphenylpropionic acid] which results in decreased abundance of Glutathione
CTD PMID:20685355 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
JBrowse link
nandrolone phenpropionate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions
affects localization
ISO nandrolone phenpropionate binds to and results in increased activity of AR protein
nandrolone phenpropionate affects the localization of AR protein
CTD PMID:28478275 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    role 20009
      biological role 20008
        antimicrobial agent 17758
          antifungal agent 15844
            3-phenylpropionic acid 6
              2-aminobenzoylacetic acid 0
              3-(3,4-dihydroxyphenyl)propanoic acid + 2
              3-(p-nitrophenyl)propanoic acid 0
              3-hydroxy-3-phenylpropionic acid + 0
              3-phenylpropanoyl-CoA 0
              3-phenylpropionate ester + 1
              propyl dihydroferulate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19873
                          organic molecular entity 19873
                            organic group 18943
                              organic divalent group 18928
                                organodiyl group 18928
                                  carbonyl group 18877
                                    carbonyl compound 18877
                                      carboxylic acid 18565
                                        monocarboxylic acid 17748
                                          fatty acid 16149
                                            saturated fatty acid 16127
                                              propionic acid 3750
                                                3-phenylpropionic acid 6
                                                  2-aminobenzoylacetic acid 0
                                                  3-(3,4-dihydroxyphenyl)propanoic acid + 2
                                                  3-(p-nitrophenyl)propanoic acid 0
                                                  3-hydroxy-3-phenylpropionic acid + 0
                                                  3-phenylpropanoyl-CoA 0
                                                  3-phenylpropionate ester + 1
                                                  propyl dihydroferulate 0
paths to the root