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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:p-tolualdehyde
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Accession:CHEBI:28617 term browser browse the term
Definition:A tolualdehyde compound with the methyl substituent at the 4-position.
Synonyms:related_synonym: 4-Methylbenzaldehyde;   4-Tolualdehyde;   4-Toluylaldehyde;   Formula=C8H8O;   InChI=1S/C8H8O/c1-7-2-4-8(6-9)5-3-7/h2-6H,1H3;   InChIKey=FXLOVSHXALFLKQ-UHFFFAOYSA-N;   PTAL;   Paratolualdehyde;   SMILES=Cc1ccc(C=O)cc1;   p-Formyltoluene;   p-Methylbenzaldehyde;   p-Toluylaldehyde;   p-Tolylaldehyde;   para-Methylbenzaldehyde;   para-Tolualdehyde;   para-Toluyl aldehyde
 alt_id: CHEBI:10632;   CHEBI:25831
 xref: CAS:104-87-0;   Gmelin:27123;   HMDB:HMDB0029638;   KEGG:C06758
 xref_mesh: MESH:C020627
 xref: MetaCyc:CPD-8773;   PMID:17019936;   PMID:20016999;   PMID:21982394;   Reaxys:385772;   Wikipedia:4-Methylbenzaldehyde


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p-tolualdehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO 4-methylbenzaldehyde binds to and results in decreased activity of AHR protein CTD PMID:27633901 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Ar androgen receptor multiple interactions ISO 4-methylbenzaldehyde binds to and results in decreased activity of AR protein CTD PMID:27633901 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO 4-methylbenzaldehyde binds to and results in decreased activity of ESR2 protein CTD PMID:27633901 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IL1B protein] CTD PMID:27569861 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:27569861 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:27569861 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:27569861 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein] CTD PMID:27569861 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:27569861 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:27569861 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO 4-methylbenzaldehyde binds to and results in decreased activity of PGR protein CTD PMID:27633901 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO 4-methylbenzaldehyde binds to and results in decreased activity of PPARG protein CTD PMID:27633901 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:27569861 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:27569861 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:27569861 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20841
    role 20801
      biological role 20799
        biochemical role 20250
          metabolite 20231
            eukaryotic metabolite 19947
              plant metabolite 18259
                p-tolualdehyde 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 20841
    subatomic particle 20839
      composite particle 20839
        hadron 20839
          baryon 20839
            nucleon 20839
              atomic nucleus 20839
                atom 20839
                  main group element atom 20762
                    p-block element atom 20786
                      carbon group element atom 20695
                        carbon atom 20690
                          organic molecular entity 20690
                            heteroorganic entity 20202
                              organochalcogen compound 19889
                                organooxygen compound 19791
                                  carbon oxoacid 19142
                                    carboxylic acid 19139
                                      carboacyl group 18069
                                        univalent carboacyl group 18069
                                          formyl group 9406
                                            aldehyde 9406
                                              arenecarbaldehyde 146
                                                benzaldehydes 143
                                                  tolualdehyde 18
                                                    p-tolualdehyde 15
paths to the root