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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:farnesol
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Accession:CHEBI:28600 term browser browse the term
Definition:A farnesane sesquiterpenoid that is dodeca-2,6,10-triene substituted by methyl groups at positions 3, 7 and 11 and a hydroxy group at position 1.
Synonyms:exact_synonym: 3,7,11-trimethyldodeca-2,6,10-trien-1-ol
 related_synonym: 3,7,11-trimethyl-2,6,10-dodecatrien-1-ol;   3,7,11-trimethyl-2,6,10-dodecatrienol;   Formula=C15H26O;   InChI=1S/C15H26O/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-16/h7,9,11,16H,5-6,8,10,12H2,1-4H3;   InChIKey=CRDAMVZIKSXKFV-UHFFFAOYSA-N;   SMILES=[H]C(CO)=C(C)CCC([H])=C(C)CCC=C(C)C;   farnesyl alcohol
 alt_id: CHEBI:24013;   CHEBI:24014;   CHEBI:4978
 xref: Beilstein:1763926;   CAS:4602-84-0;   DrugBank:DB02509;   HMDB:HMDB0004305;   KEGG:C01493;   KNApSAcK:C00003132;   LINCS:LSM-5398
 xref_mesh: MESH:D005204
 xref: PMID:17640272;   PMID:19402910;   PMID:23902158;   PMID:24987733;   Reaxys:1763926


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farnesol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa1a acetyl-CoA acyltransferase 1A multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of ACAA1 mRNA CTD PMID:30611723 NCBI chr 8:119,079,401...119,088,624
Ensembl chr 8:119,079,775...119,088,624
JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 multiple interactions
increases expression
ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of ACAA2 mRNA
Farnesol analog results in increased expression of ACAA2 mRNA
CTD PMID:30611723 NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of ACADM mRNA CTD PMID:30611723 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
JBrowse link
G Acads acyl-CoA dehydrogenase short chain multiple interactions
increases expression
ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of ACADS mRNA
Farnesol analog results in increased expression of ACADS mRNA
CTD PMID:30611723 NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898
JBrowse link
G Acat1 acetyl-CoA acetyltransferase 1 increases expression ISO Farnesol analog results in increased expression of ACAT1 mRNA CTD PMID:30611723 NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855
JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 increases expression ISO Farnesol analog results in increased expression of ACAT2 mRNA CTD PMID:30611723 NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821
JBrowse link
G Acot1 acyl-CoA thioesterase 1 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of ACOT1 mRNA CTD PMID:30611723 NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163
JBrowse link
G Acot12 acyl-CoA thioesterase 12 increases expression
multiple interactions
ISO Farnesol analog results in increased expression of ACOT12 mRNA
[Farnesol analog co-treated with Oleic Acid] results in increased expression of ACOT12 mRNA
CTD PMID:30611723 NCBI chr 2:22,986,867...23,027,538
Ensembl chr 2:22,986,626...23,027,536
JBrowse link
G Acot6 acyl-CoA thioesterase 6 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in decreased expression of ACOT6 mRNA CTD PMID:30611723 NCBI chr 6:103,732,372...103,741,446
Ensembl chr 6:103,732,372...103,741,446
JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of ACOX1 mRNA CTD PMID:30611723 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Acox2 acyl-CoA oxidase 2 decreases expression
increases expression
ISO Farnesol analog results in decreased expression of ACOX2 mRNA
Farnesol analog results in increased expression of ACOX2 mRNA
CTD PMID:30611723 NCBI chr15:16,660,584...16,692,160
Ensembl chr15:16,660,272...16,692,160
JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of ACSL4 mRNA CTD PMID:30611723 NCBI chr  X:105,942,794...106,006,573
Ensembl chr  X:105,942,799...106,006,427
JBrowse link
G Acsl5 acyl-CoA synthetase long-chain family member 5 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of ACSL5 mRNA CTD PMID:30611723 NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607
JBrowse link
G Agpat1 1-acylglycerol-3-phosphate O-acyltransferase 1 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in decreased expression of AGPAT1 mRNA CTD PMID:30611723 NCBI chr20:4,135,955...4,144,880
Ensembl chr20:4,135,957...4,145,278
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases chemical synthesis ISO AKR1B10 protein results in increased chemical synthesis of Farnesol CTD PMID:21187079 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases chemical synthesis
multiple interactions
ISO AKR1C3 protein results in increased chemical synthesis of Farnesol
[Flurbiprofen results in decreased activity of AKR1C3 protein] which results in increased metabolism of Farnesol; [tolfenamic acid results in decreased activity of AKR1C3 protein] which results in increased metabolism of Farnesol
CTD PMID:21187079 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Apoa5 apolipoprotein A5 multiple interactions
increases expression
ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of APOA5 mRNA
Farnesol analog results in increased expression of APOA5 mRNA
CTD PMID:30611723 NCBI chr 8:46,561,180...46,563,818
Ensembl chr 8:46,561,229...46,563,816
JBrowse link
G Apoc4 apolipoprotein C4 decreases expression ISO Farnesol analog results in decreased expression of APOC4 mRNA CTD PMID:30611723 NCBI chr 1:79,335,745...79,339,942
Ensembl chr 1:79,335,745...79,339,981
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Farnesol results in increased expression of ATF3 mRNA CTD PMID:27965148 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO Farnesol results in increased expression of BAK1 protein CTD PMID:12530055 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Casp3 caspase 3 increases activity
decreases activity
ISO
EXP
Farnesol results in increased activity of CASP3 protein
Farnesol results in decreased activity of CASP3 protein
CTD PMID:10733934 PMID:21453689 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase increases expression
multiple interactions
EXP Farnesol results in increased expression of CAT protein
Farnesol inhibits the reaction [Tobacco Smoke Pollution results in decreased activity of CAT protein]
CTD PMID:18793622 PMID:21453689 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases secretion ISO Farnesol results in increased secretion of CCL4 protein CTD PMID:30806763 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Farnesol results in decreased expression of CCNA2 protein CTD PMID:17138864 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Farnesol results in decreased expression of CCNB1 protein CTD PMID:17138864 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression
multiple interactions
ISO Farnesol results in decreased expression of CDK2 protein
Farnesol promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein]; Farnesol promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein]
CTD PMID:17138864 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
increases response to substance
ISO Farnesol promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein]
Farnesol results in increased expression of CDKN1A protein
CDKN1A protein results in increased susceptibility to Farnesol
CTD PMID:17138864 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases response to substance
increases expression
multiple interactions
ISO CDKN1B protein results in increased susceptibility to Farnesol
Farnesol results in increased expression of CDKN1B protein
Farnesol promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein]
CTD PMID:17138864 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cox10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 decreases expression ISO Farnesol analog results in decreased expression of COX10 mRNA CTD PMID:30611723 NCBI chr10:48,630,993...48,742,835
Ensembl chr10:48,630,676...48,746,667
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of CPT1A mRNA CTD PMID:30611723 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases activity EXP Farnesol results in increased activity of CYP19A1 protein CTD PMID:15840382 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity
increases expression
EXP
ISO
Farnesol results in increased activity of CYP1A1 protein
Farnesol results in increased expression of CYP1A1 mRNA
CTD PMID:15840382 PMID:30806763 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity
multiple interactions
EXP
ISO
Farnesol results in increased activity of CYP1A2 protein
Farnesol analog inhibits the reaction [Oleic Acid results in decreased expression of CYP1A2 mRNA]
CTD PMID:15840382 PMID:30611723 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 increases activity EXP Farnesol results in increased activity of CYP2A1 protein CTD PMID:15840382 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
JBrowse link
G Cyp2a2 cytochrome P450, family 2, subfamily a, polypeptide 2 increases activity EXP Farnesol results in increased activity of CYP2A2 protein CTD PMID:15840382 NCBI chr 1:82,263,833...82,289,487
Ensembl chr 1:82,263,833...82,289,487
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases activity EXP Farnesol results in increased activity of CYP2A3 protein CTD PMID:15840382 NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases activity EXP Farnesol results in increased activity of CYP2B1 protein CTD PMID:15840382 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases activity EXP Farnesol results in increased activity of CYP2B2 protein CTD PMID:15840382 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases expression
ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of CYP2B6 mRNA; Farnesol analog inhibits the reaction [Oleic Acid results in decreased expression of CYP2B6 mRNA]
Farnesol analog results in increased expression of CYP2B6 mRNA; Farnesol results in increased expression of CYP2B6 mRNA
CTD PMID:30611723 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases activity EXP Farnesol results in increased activity of CYP2C11 protein CTD PMID:15840382 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c12 cytochrome P450, family 2, subfamily c, polypeptide 12 increases activity EXP Farnesol results in increased activity of CYP2C12 protein CTD PMID:15840382 NCBI chr 1:238,699,859...238,757,011
Ensembl chr 1:238,699,854...238,757,019
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases activity
multiple interactions
decreases expression
EXP
ISO
Farnesol results in increased activity of CYP2E1 protein
[Farnesol analog co-treated with Oleic Acid] results in increased expression of CYP2E1 mRNA; Farnesol analog inhibits the reaction [Oleic Acid results in increased expression of CYP2E1 mRNA]
Farnesol analog results in decreased expression of CYP2E1 mRNA; Farnesol results in decreased expression of CYP2E1 mRNA
CTD PMID:15840382 PMID:30611723 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases activity
increases expression
multiple interactions
EXP
ISO
Farnesol results in increased activity of CYP3A2 protein
Farnesol results in increased expression of CYP3A4 mRNA
Farnesol analog inhibits the reaction [Oleic Acid results in decreased expression of CYP3A4 mRNA]
CTD PMID:15840382 PMID:30611723 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases activity EXP Farnesol results in increased activity of CYP3A23-3A1 protein CTD PMID:15840382 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases activity EXP Farnesol results in increased activity of CYP4A1 protein CTD PMID:15840382 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
JBrowse link
G Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 increases activity EXP Farnesol results in increased activity of CYP4A2 protein CTD PMID:15840382 NCBI chr 5:128,922,355...128,934,188
Ensembl chr 5:128,923,615...128,934,165
JBrowse link
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 increases activity EXP Farnesol results in increased activity of CYP4A3 protein CTD PMID:15840382 NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463
JBrowse link
G Decr1 2,4-dienoyl-CoA reductase 1 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in decreased expression of DECR1 mRNA CTD PMID:30611723 NCBI chr 5:29,411,172...29,439,054
Ensembl chr 5:29,411,172...29,439,018
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 decreases expression ISO Farnesol analog results in decreased expression of DGAT1 mRNA CTD PMID:30611723 NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299
JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of DGAT2 mRNA CTD PMID:30611723 NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO Farnesol results in increased expression of DNAJB4 mRNA CTD PMID:27965148 NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089
JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression ISO Farnesol analog results in increased expression of ECH1 mRNA CTD PMID:30611723 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
JBrowse link
G Egf epidermal growth factor multiple interactions ISO Farnesol analog inhibits the reaction [EGF protein results in increased activity of RHOA protein]; Farnesol analog results in decreased susceptibility to [INS protein co-treated with EGF protein] CTD PMID:24587105 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of ELOVL6 mRNA CTD PMID:30611723 NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Farnesol analog results in increased expression of FABP1 mRNA CTD PMID:30611723 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression ISO Farnesol results in increased expression of FABP4 mRNA CTD PMID:30806763 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of FASN mRNA CTD PMID:30611723 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases expression ISO Farnesol analog results in increased expression of FDFT1 mRNA CTD PMID:30611723 NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
JBrowse link
G Fnta farnesyltransferase, CAAX box, alpha multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of FNTA mRNA CTD PMID:30611723 NCBI chr16:66,065,131...66,083,460
Ensembl chr16:66,065,132...66,083,460
JBrowse link
G Fntb farnesyltransferase, CAAX box, beta decreases expression ISO Farnesol analog results in decreased expression of FNTB mRNA CTD PMID:30611723 NCBI chr 6:95,536,540...95,619,587
Ensembl chr 6:95,470,683...95,619,586
JBrowse link
G Gpat4 glycerol-3-phosphate acyltransferase 4 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of GPAT4 mRNA CTD PMID:30611723 NCBI chr16:68,819,031...68,852,903
Ensembl chr16:68,819,079...68,852,901
JBrowse link
G Gsr glutathione-disulfide reductase increases activity
increases expression
EXP Farnesol results in increased activity of GSR protein
Farnesol results in increased expression of GSR protein
CTD PMID:15840382 PMID:21453689 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha increases expression
multiple interactions
ISO Farnesol analog results in increased expression of HADHA mRNA
[Farnesol analog co-treated with Oleic Acid] results in increased expression of HADHA mRNA
CTD PMID:30611723 NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869
JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta increases expression
multiple interactions
ISO Farnesol analog results in increased expression of HADHB mRNA
[Farnesol analog co-treated with Oleic Acid] results in increased expression of HADHB mRNA
CTD PMID:30611723 NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
increases expression
decreases activity
ISO
EXP
[Farnesol analog co-treated with Oleic Acid] results in increased expression of HMGCR mRNA
Farnesol results in increased expression of HMGCR protein
Farnesol results in decreased activity of HMGCR protein
CTD PMID:12477733 PMID:16332721 PMID:30611723 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Farnesol results in increased expression of HMOX1 mRNA CTD PMID:30806763 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO Farnesol inhibits the reaction [Simvastatin results in decreased farnesylation of and affects the localization of HRAS protein] CTD PMID:12477733 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO Farnesol results in increased expression of ICAM1 mRNA CTD PMID:30806763 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il16 interleukin 16 increases secretion ISO Farnesol results in increased secretion of IL16 protein CTD PMID:30806763 NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Farnesol results in increased expression of IL1A mRNA CTD PMID:30806763 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Farnesol inhibits the reaction [[MVK gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of IL1B protein]
Farnesol inhibits the reaction [[Alendronate co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]
CTD PMID:20304105 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1r2 interleukin 1 receptor type 2 increases expression ISO Farnesol results in increased expression of IL1R2 mRNA CTD PMID:30806763 NCBI chr 9:42,384,280...42,424,726
Ensembl chr 9:42,384,433...42,424,725
JBrowse link
G Ins2 insulin 2 multiple interactions ISO Farnesol analog results in decreased susceptibility to [INS protein co-treated with EGF protein] CTD PMID:24587105 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Lipc lipase C, hepatic type increases expression ISO Farnesol analog results in increased expression of LIPC mRNA CTD PMID:30611723 NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464
JBrowse link
G Lpin1 lipin 1 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of LPIN1 mRNA CTD PMID:30611723 NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097
JBrowse link
G Lpin3 lipin 3 decreases expression ISO Farnesol analog results in decreased expression of LPIN3 mRNA CTD PMID:30611723 NCBI chr 3:149,533,719...149,558,494
Ensembl chr 3:149,534,051...149,558,327
JBrowse link
G Mlxipl MLX interacting protein-like multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in decreased expression of MLXIPL mRNA CTD PMID:30611723 NCBI chr12:21,542,964...21,577,120
Ensembl chr12:21,543,576...21,577,112
JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression ISO Farnesol results in increased expression of MMP3 mRNA CTD PMID:30806763 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Mvk mevalonate kinase decreases activity
multiple interactions
ISO Farnesol results in decreased activity of MVK protein
Farnesol inhibits the reaction [[MVK gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of IL1B protein]; Farnesol inhibits the reaction [MVK gene mutant form results in increased susceptibility to Lipopolysaccharides]; Farnesol inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; Farnesol inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]
CTD PMID:9392419 PMID:20304105 NCBI chr12:42,141,391...42,158,858
Ensembl chr12:42,141,384...42,158,882
JBrowse link
G Myl9 myosin light chain 9 multiple interactions ISO Farnesol analog inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of MYL9 protein] CTD PMID:24587105 NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity EXP Farnesol results in increased activity of NQO1 protein CTD PMID:15840382 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression
multiple interactions
ISO Farnesol analog results in decreased expression of NR0B2 mRNA
[Farnesol analog co-treated with Oleic Acid] results in decreased expression of NR0B2 mRNA
CTD PMID:30611723 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
decreases expression
ISO Farnesol binds to and results in increased activity of NR1H4 protein
Farnesol analog results in decreased expression of NR1H4 mRNA
CTD PMID:15491415 PMID:30611723 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions
decreases expression
ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of PCK1 mRNA
Farnesol analog results in decreased expression of PCK1 mRNA
CTD PMID:30611723 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
JBrowse link
G Pdss1 decaprenyl diphosphate synthase subunit 1 increases expression ISO Farnesol analog results in increased expression of PDSS1 mRNA CTD PMID:30611723 NCBI chr17:85,059,953...85,098,739
Ensembl chr17:85,060,106...85,098,730
JBrowse link
G Plin2 perilipin 2 increases expression
multiple interactions
ISO Farnesol analog results in increased expression of PLIN2 mRNA
[Farnesol analog co-treated with Oleic Acid] results in increased expression of PLIN2 mRNA
CTD PMID:30611723 NCBI chr 5:101,156,643...101,211,738
Ensembl chr 5:101,154,411...101,242,319
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of PPARA mRNA; Farnesol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]] CTD PMID:11779144 PMID:30611723 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression
ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of PPARG mRNA
Farnesol analog results in increased expression of PPARG mRNA
CTD PMID:30611723 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP Farnesol inhibits the reaction [Atorvastatin inhibits the reaction [TNF protein results in decreased expression of PPARGC1A protein]] CTD PMID:22343369 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Rabggta Rab geranylgeranyltransferase subunit alpha multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in decreased expression of RABGGTA mRNA CTD PMID:30611723 NCBI chr15:29,206,328...29,213,398
Ensembl chr15:29,206,157...29,213,348
JBrowse link
G Rabggtb Rab geranylgeranyltransferase subunit beta multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in decreased expression of RABGGTB mRNA CTD PMID:30611723 NCBI chr 2:242,844,758...242,850,022
Ensembl chr 2:242,844,762...242,851,050
JBrowse link
G Rhoa ras homolog family member A multiple interactions EXP
ISO
Farnesol inhibits the reaction [Lovastatin affects the localization of RHOA protein]
Farnesol analog inhibits the reaction [EGF protein results in increased activity of RHOA protein]; Farnesol analog inhibits the reaction [lysophosphatidic acid results in increased activity of RHOA protein]
CTD PMID:9398081 PMID:24587105 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Rhoc ras homolog family member C multiple interactions ISO Farnesol analog inhibits the reaction [lysophosphatidic acid results in increased activity of RHOC protein] CTD PMID:24587105 NCBI chr 2:192,287,065...192,293,292
Ensembl chr 2:192,287,130...192,295,306
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO Farnesol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]] CTD PMID:11779144 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in decreased expression of SCD mRNA CTD PMID:30611723 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Serpinb3 serpin family B member 3 increases expression ISO Farnesol results in increased expression of SERPINB3 mRNA CTD PMID:30806763 NCBI chr13:23,274,120...23,280,082
Ensembl chr13:23,274,484...23,313,682
JBrowse link
G Slc25a20 solute carrier family 25 member 20 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of SLC25A20 mRNA CTD PMID:30611723 NCBI chr 8:109,365,056...109,386,512
Ensembl chr 8:109,365,002...109,386,512
JBrowse link
G Slc27a1 solute carrier family 27 member 1 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of SLC27A1 mRNA CTD PMID:30611723 NCBI chr16:18,278,984...18,300,173
Ensembl chr16:18,278,984...18,296,063
JBrowse link
G Slc27a2 solute carrier family 27 member 2 increases expression ISO Farnesol analog results in increased expression of SLC27A2 mRNA CTD PMID:30611723 NCBI chr 3:113,804,728...113,842,208
Ensembl chr 3:113,804,728...113,842,208
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Farnesol results in increased expression of SLC7A11 mRNA CTD PMID:30806763 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP
ISO
Farnesol inhibits the reaction [Atorvastatin inhibits the reaction [TNF protein results in decreased expression of PPARGC1A protein]]
Farnesol results in increased expression of TNF mRNA
CTD PMID:22343369 PMID:30806763 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Farnesol CTD PMID:15320866 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Farnesol CTD PMID:15320866 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of Farnesol CTD PMID:15320866 NCBI chr 9:88,762,250...88,808,465 JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases glucuronidation ISO UGT1A6 protein results in increased glucuronidation of Farnesol CTD PMID:15320866 NCBI chr 9:88,747,229...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Farnesol CTD PMID:15320866 NCBI chr 9:88,696,981...88,808,465 JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation ISO UGT2B7 protein results in increased glucuronidation of Farnesol CTD PMID:15320866 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        antimicrobial agent 17408
          farnesol 107
            (2-cis,6-cis)-farnesol 0
            (2-cis,6-trans)-farnesol 0
            (2-trans,6-cis)-farnesol 0
            (2-trans,6-trans)-farnesol + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    main group molecular entity 19716
                      s-block molecular entity 19502
                        hydrogen molecular entity 19498
                          hydrides 18852
                            organic hydride 18353
                              organic fundamental parent 18353
                                hydrocarbon 18066
                                  terpene 12711
                                    terpenoid 12280
                                      sesquiterpenoid 2727
                                        farnesane sesquiterpenoid 126
                                          farnesol 107
                                            (2-cis,6-cis)-farnesol 0
                                            (2-cis,6-trans)-farnesol 0
                                            (2-trans,6-cis)-farnesol 0
                                            (2-trans,6-trans)-farnesol + 0
paths to the root