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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:quinidine
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Accession:CHEBI:28593 term browser browse the term
Definition:A cinchona alkaloid consisting of cinchonine with the hydrogen at the 6-position of the quinoline ring substituted by methoxy.
Synonyms:exact_synonym: (9S)-6'-methoxycinchonan-9-ol
 related_synonym: (8R,9S)-quinidine;   (R)-(6-methoxyquinolin-4-yl)((3S,4R,7S)-3-vinylquinuclidin-7-yl)methanol;   (S)-(6-Methoxy-quinolin-4-yl)-((2R,5R)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol;   (S)-(6-methoxyquinolin-4-yl)((2R,5R)-5-vinylquinuclidin-2-yl)methanol;   6-methoxy-alpha-(5-vinyl-2-quinuclidinyl)-4-quinolinemethanol;   CIN-QUIN;   Chinidin;   Conchinin;   Formula=C20H24N2O2;   InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19+,20-/m0/s1;   InChIKey=LOUPRKONTZGTKE-LHHVKLHASA-N;   Kinidin;   SMILES=[H][C@@]1(C[C@@H]2CC[N@]1C[C@@H]2C=C)[C@@H](O)c1ccnc2ccc(OC)cc12;   alpha-(6-methoxy-4-quinolyl)-5-vinyl-2-quinuclidinemethanol;   beta-quinine;   chinidinum;   conquinine;   pitayine;   quinidina
 alt_id: CHEBI:127150;   CHEBI:26494;   CHEBI:355477;   CHEBI:529982;   CHEBI:595841;   CHEBI:597286;   CHEBI:604323;   CHEBI:8719
 xref: CAS:56-54-2;   DrugBank:DB00908;   Drug_Central:2346;   KEGG:C06527;   KEGG:D08458;   LINCS:LSM-3325
 xref_mesh: MESH:D011802
 xref: PMID:12477351;   PMID:12699389;   PMID:14971904;   PMID:14973303;   PMID:15089813;   PMID:15225721;   PMID:15270556;   PMID:15328252;   PMID:16570918;   PMID:17132069;   PMID:17228875;   PMID:17249648;   PMID:17870541;   PMID:18324762;   PMID:18395298;   PMID:18788725;   PMID:23861085;   PMID:24130427;   PMID:445303;   PMID:8337232;   PMID:9864343;   Reaxys:91866



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quinidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
affects response to substance
decreases expression
affects transport
affects binding
multiple interactions
ISO ABCB1 protein results in increased transport of Quinidine
ABCB1A protein affects the susceptibility to Quinidine
Quinidine results in decreased expression of ABCB1 protein
ABCB1 protein affects the transport of Quinidine
Quinidine binds to ABCB1 protein
methoxyfenozide inhibits the reaction [ABCB1 protein results in increased transport of Quinidine]; Quinidine inhibits the reaction [ABCB1 protein results in decreased susceptibility to Docetaxel]; Quinidine inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; tebufenozide inhibits the reaction [ABCB1 protein results in increased transport of Quinidine]
CTD PMID:15502009 PMID:15616150 PMID:20196146 PMID:23976943 PMID:26995013 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135
JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B affects response to substance
affects activity
ISO
EXP
ABCB1B protein affects the susceptibility to Quinidine
Quinidine affects the activity of ABCB1B protein
CTD PMID:12626638 PMID:15502009 NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:26,106,903...26,279,567
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain decreases expression EXP Quinidine results in decreased expression of ACADM mRNA CTD PMID:17522070 NCBI chr 2:245,518,693...245,542,864
Ensembl chr 2:245,518,693...245,542,864
JBrowse link
G Ace2 angiotensin converting enzyme 2 decreases expression ISO Quinidine results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:33,925,458...33,972,851
Ensembl chr  X:33,925,458...33,971,596
JBrowse link
G Adra1a adrenoceptor alpha 1A affects binding
multiple interactions
ISO Quinidine binds to ADRA1A protein
[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Quinidine inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]
CTD PMID:9570190 NCBI chr15:45,005,648...45,111,416
Ensembl chr15:45,005,799...45,102,534
JBrowse link
G Adra1b adrenoceptor alpha 1B affects binding
multiple interactions
ISO Quinidine binds to ADRA1B protein
[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Quinidine inhibits the reaction [ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate]
CTD PMID:9570190 NCBI chr10:28,756,461...28,874,831
Ensembl chr10:28,756,461...28,814,347
JBrowse link
G Adra1d adrenoceptor alpha 1D affects binding
multiple interactions
ISO Quinidine binds to ADRA1D protein
[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Quinidine inhibits the reaction [ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate]
CTD PMID:9570190 NCBI chr 3:139,246,333...139,262,331
Ensembl chr 3:139,246,323...139,262,331
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression EXP Quinidine results in increased expression of ALDOA mRNA CTD PMID:17522070 NCBI chr 1:190,832,820...190,838,021
Ensembl chr 1:190,832,820...190,838,211
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Quinidine results in increased expression of ASNS mRNA CTD PMID:15342952 NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050
JBrowse link
G Cat catalase increases expression ISO Quinidine results in increased expression of CAT protein CTD PMID:12708743 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Quinidine results in increased expression of CDKN1A protein CTD PMID:12243503 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 increases expression EXP Quinidine results in increased expression of CEACAM1 mRNA CTD PMID:17522070 NCBI chr 1:90,171,401...90,187,810
Ensembl chr 1:90,171,401...90,187,798
JBrowse link
G Cyb5r3 cytochrome b5 reductase 3 decreases expression EXP Quinidine results in decreased expression of CYB5R3 mRNA CTD PMID:17522070 NCBI chr 7:116,186,729...116,204,290
Ensembl chr 7:116,186,729...116,204,306
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
ISO Quinidine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Quinidine results in decreased activity of CYP1A1 protein
CTD PMID:18420780 PMID:18493746 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
ISO Quinidine affects the reaction [CYP1A2 protein results in increased oxidation of 4-amino-2-phenoxymethanesulfonanilide]
Quinidine results in decreased activity of CYP1A2 protein
CTD PMID:15916432 PMID:19053182 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Quinidine results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 decreases activity ISO Quinidine results in decreased activity of CYP2A4 protein CTD PMID:18420780 NCBI chr 1:91,299,584...91,307,650
Ensembl chr 1:91,299,561...91,307,649
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity ISO Quinidine results in decreased activity of CYP2B10 protein CTD PMID:18420780 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity
multiple interactions
EXP
ISO
Quinidine results in decreased activity of CYP2C6 protein
Quinidine results in decreased activity of CYP2C29 protein
Quinidine affects the reaction [CYP2C19 protein results in increased oxidation of 4-amino-2-phenoxymethanesulfonanilide]
CTD PMID:12814958 PMID:18420780 PMID:19053182 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798
JBrowse link
G Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 multiple interactions EXP Quinidine inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin] CTD PMID:19858067 NCBI chr 7:115,815,212...115,819,281
Ensembl chr 7:115,815,212...115,819,281
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
decreases activity
multiple interactions
ISO
EXP
CYP2D6 protein results in increased metabolism of Quinidine
Quinidine results in decreased activity of CYP2D6 protein
[Quinidine results in decreased activity of CYP2D6 protein] which results in decreased glutathionylation of Duloxetine Hydrochloride
Quinidine results in decreased activity of CYP2D6 gene mutant form; Quinidine results in decreased activity of CYP2D6 protein
[Quinidine results in decreased activity of CYP2D6 protein] which affects the susceptibility to Oxycodone; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased chemical synthesis of 16-O-demethylaconitine; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased chemical synthesis of 4-hydroxy-N-desmethyltamoxifen; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased chemical synthesis of Aconitine metabolite; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased hydroxylation of N-desmethyltamoxifen; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; Quinidine affects the reaction [CYP2D6 protein polymorphism affects the metabolism of dacomitinib]; Quinidine binds to and results in decreased activity of CYP2D6 protein; Quinidine inhibits the reaction [3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin results in increased metabolism of CYP2D6 protein]; Quinidine inhibits the reaction [[CYP2D6 protein results in increased metabolism of 7-methoxy-4-(aminomethyl)coumarin] which results in increased chemical synthesis of Coumarins]; Quinidine inhibits the reaction [CYP2D6 protein affects the metabolism of 1-(3-chlorophenyl)piperazine]; Quinidine inhibits the reaction [CYP2D6 protein results in increased chemical synthesis of Dextrorphan]; Quinidine inhibits the reaction [CYP2D6 protein results in increased hydrolysis of bufuralol]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Atomoxetine Hydrochloride]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of auriculasin]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of bufuralol]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of tegaserod]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of YM 758]; Quinidine inhibits the reaction [notopterol results in decreased activity of CYP2D6 protein]
CTD PMID:8819299 PMID:11377097 PMID:11560869 PMID:11673748 PMID:12464242 More... NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Quinidine results in decreased activity of CYP2E1 protein CTD PMID:18420780 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
affects metabolic processing
ISO Quinidine inhibits the reaction [CYP3A4 protein results in increased metabolism of YM 758]; Quinidine inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]
CYP3A4 protein affects the metabolism of Quinidine
CTD PMID:2271712 PMID:15784650 PMID:19230594 PMID:19299527 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Depp1 DEPP autophagy regulator 1 increases expression ISO Quinidine results in increased expression of DEPP1 mRNA CTD PMID:17567588 NCBI chr 4:151,583,105...151,585,455
Ensembl chr 4:151,581,502...151,586,233
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Quinidine results in increased expression of FABP1 mRNA CTD PMID:17567588 NCBI chr 4:104,744,302...104,753,119
Ensembl chr 4:104,744,309...104,753,113
JBrowse link
G Fga fibrinogen alpha chain increases expression EXP Quinidine results in increased expression of FGA mRNA CTD PMID:17522070 NCBI chr 2:170,672,169...170,679,572
Ensembl chr 2:170,672,012...170,679,577
JBrowse link
G Fgb fibrinogen beta chain increases expression EXP Quinidine results in increased expression of FGB mRNA CTD PMID:17522070 NCBI chr 2:170,693,966...170,700,875
Ensembl chr 2:170,692,965...170,705,434
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases activity ISO Quinidine results in decreased activity of GSTM1 protein CTD PMID:11807801 NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases expression EXP Quinidine results in decreased expression of GSTM3 mRNA CTD PMID:17522070 NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:198,219,647...198,222,731
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
decreases activity
ISO Quinidine inhibits the reaction [GSTP1 protein affects the metabolism of and results in decreased activity of Ethacrynic Acid]
Quinidine results in decreased activity of GSTP1 protein
CTD PMID:11807801 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705
JBrowse link
G Hibadh 3-hydroxyisobutyrate dehydrogenase increases expression EXP Quinidine results in increased expression of HIBADH mRNA CTD PMID:17522070 NCBI chr 4:81,649,180...81,747,244
Ensembl chr 4:82,979,765...83,111,242
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO Quinidine inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein] CTD PMID:17520698 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764
JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Quinidine results in increased expression of INHBE mRNA CTD PMID:15342952 NCBI chr 7:65,061,531...65,064,519
Ensembl chr 7:65,061,531...65,064,519
JBrowse link
G Kcnh1 potassium voltage-gated channel subfamily H member 1 multiple interactions ISO Quinidine inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein] CTD PMID:17520698 NCBI chr13:106,253,101...106,555,712
Ensembl chr13:106,253,213...106,555,710
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
affects activity
affects binding
affects localization
affects response to substance
decreases response to substance
ISO [Quinidine results in decreased activity of KCNH2 protein] which results in decreased import of Thallium; Acids inhibits the reaction [Quinidine results in decreased activity of KCNH2 protein]; naringenin promotes the reaction [Quinidine results in decreased activity of KCNH2 protein]; Potassium inhibits the reaction [Quinidine results in decreased activity of KCNH2 protein]; Quinidine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Quinidine promotes the reaction [naringenin results in decreased activity of KCNH2 protein]
Quinidine affects the activity of KCNH2 protein
Quinidine binds to KCNH2 protein
Quinidine affects the localization of KCNH2 protein mutant form
KCNH2 gene SNP affects the susceptibility to Quinidine
KCNH2 gene mutant form results in decreased susceptibility to Quinidine
CTD PMID:11741928 PMID:12695533 PMID:15671647 PMID:15673388 PMID:15821840 More... NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421
JBrowse link
G Kcnk1 potassium two pore domain channel subfamily K member 1 multiple interactions ISO Quinidine affects the reaction [KCNK1 protein results in increased transport of Potassium]; Quinidine inhibits the reaction [KCNK1 protein results in increased transport of Sodium] CTD PMID:16847696 NCBI chr19:70,856,985...70,895,053
Ensembl chr19:70,856,985...70,895,051
JBrowse link
G Kcnk18 potassium two pore domain channel subfamily K member 18 multiple interactions ISO Quinidine inhibits the reaction [KCNK18 protein results in increased transport of Potassium] CTD PMID:12754259 NCBI chr 1:258,374,671...258,388,945
Ensembl chr 1:268,360,738...268,375,012
JBrowse link
G Kcnk9 potassium two pore domain channel subfamily K member 9 multiple interactions EXP Quinidine inhibits the reaction [KCNK9 protein results in increased transport of Potassium] CTD PMID:10734076 NCBI chr 7:106,316,783...106,362,452
Ensembl chr 7:106,326,684...106,361,921
JBrowse link
G Lbp lipopolysaccharide binding protein increases expression EXP Quinidine results in increased expression of LBP mRNA CTD PMID:17522070 NCBI chr 3:167,373,786...167,400,941
Ensembl chr 3:167,373,924...167,401,518
JBrowse link
G Lipc lipase C, hepatic type decreases expression EXP Quinidine results in decreased expression of LIPC mRNA CTD PMID:17522070 NCBI chr 8:80,390,470...80,516,463
Ensembl chr 8:80,390,471...80,516,285
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression EXP Quinidine results in decreased expression of MYC mRNA CTD PMID:17522070 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Quinidine results in increased expression of NUPR1 mRNA CTD PMID:17567588 NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:190,643,867...190,645,901
JBrowse link
G Otc ornithine transcarbamylase decreases expression EXP Quinidine results in decreased expression of OTC mRNA CTD PMID:17522070 NCBI chr  X:15,126,358...15,202,473
Ensembl chr  X:15,126,358...15,239,555
JBrowse link
G Pklr pyruvate kinase L/R decreases expression EXP Quinidine results in decreased expression of PKLR mRNA CTD PMID:17522070 NCBI chr 2:176,840,779...176,849,637
Ensembl chr 2:176,840,764...176,849,644
JBrowse link
G Ptma prothymosin alpha decreases expression EXP Quinidine results in decreased expression of PTMA mRNA CTD PMID:17522070 NCBI chr 9:94,624,194...94,628,276
Ensembl chr 9:94,624,196...94,628,276
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression EXP Quinidine results in increased expression of S100A9 mRNA CTD PMID:17522070 NCBI chr 2:178,487,941...178,490,622
Ensembl chr 2:178,487,941...178,490,870
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 affects response to substance ISO SCN5A gene mutant form affects the susceptibility to Quinidine CTD PMID:17805561 NCBI chr 8:128,098,613...128,196,515
Ensembl chr 8:128,098,613...128,196,470
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions EXP
ISO
[Quinidine analog results in decreased activity of SLC22A1 protein] which results in decreased import of Phenylephrine; [Quinidine analog results in decreased activity of SLC22A1 protein] which results in decreased import of Synephrine
Quinidine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Quinidine inhibits the reaction [SLC22A1 protein results in increased uptake of Monocrotaline]; Quinidine inhibits the reaction [SLC22A1 protein results in increased uptake of Quercetin]; Quinidine inhibits the reaction [SLC22A1 protein results in increased uptake of retrorsine]
CTD PMID:16141367 PMID:21140131 PMID:23831208 PMID:24799337 PMID:24947867 NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Quinidine inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Quinidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:16141367 PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO Quinidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:16141367 NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:50,783,218...50,872,353
JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Quinidine results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 4:157,632,887...157,698,034
Ensembl chr 4:157,632,887...157,646,186
JBrowse link
G Slc47a1 solute carrier family 47 member 1 decreases activity
multiple interactions
ISO Quinidine results in decreased activity of SLC47A1 protein
Quinidine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD PMID:16928787 PMID:22419765 NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,533,583...46,587,096
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Quinidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,490,262...46,532,954
Ensembl chr10:46,489,831...46,533,425
JBrowse link
G Slco1a1 solute carrier organic anion transporter family, member 1a1 decreases activity
multiple interactions
EXP Quinidine results in decreased activity of SLCO1A1 protein
Quinidine inhibits the reaction [SLCO1A1 protein results in increased uptake of estradiol-17 beta-glucuronide]
CTD PMID:11883641 NCBI chr 4:174,877,045...174,950,900
Ensembl chr 4:176,607,687...176,681,992
JBrowse link
G Tagln transgelin decreases expression ISO Quinidine results in decreased expression of TAGLN mRNA CTD PMID:17567588 NCBI chr 8:55,121,647...55,127,121
Ensembl chr 8:55,121,301...55,127,563
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Quinidine results in increased expression of TIMP1 mRNA CTD PMID:17522070 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A decreases expression EXP Quinidine results in decreased expression of TNFRSF1A mRNA CTD PMID:17522070 NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816
JBrowse link
G Tnfrsf8 TNF receptor superfamily member 8 decreases expression ISO Quinidine results in decreased expression of TNFRSF8 protein CTD PMID:12441127 NCBI chr 5:162,406,387...162,451,620
Ensembl chr 5:162,406,387...162,451,620
JBrowse link
G Tp53 tumor protein p53 decreases expression EXP Quinidine results in decreased expression of TP53 mRNA CTD PMID:17522070 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      application 20621
        pharmaceutical 20416
          drug 20416
            drug allergen 12011
              quinidine 59
                quinidine D-gluconate 0
                quinidine sulfate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            organic molecule 20654
                              organic cyclic compound 20404
                                organic heterocyclic compound 19388
                                  organic heteropolycyclic compound 18651
                                    organic heterobicyclic compound 17545
                                      quinuclidines 69
                                        cinchonan 59
                                          quinidine 59
                                            quinidine D-gluconate 0
                                            quinidine sulfate 0
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