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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:gossypol
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Accession:CHEBI:28584 term browser browse the term
Definition:A polyphenol that has formula C30H30O8.
Synonyms:alt_id: CHEBI:24427;   CHEBI:5526
 xref_mesh: MESH:D006072


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gossypol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alas1 5'-aminolevulinate synthase 1 multiple interactions
increases activity
EXP chromium protoporphyrin IX promotes the reaction [Gossypol results in increased activity of ALAS1 protein] CTD PMID:15027808 NCBI chr 8:114,927,704...114,941,038
Ensembl chr 8:114,927,722...114,940,177
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP [Gossypol co-treated with Methyltestosterone co-treated with Ethinyl Estradiol] results in increased expression of BAX mRNA CTD PMID:15451339 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO Gossypol results in increased expression of BBC3 protein CTD PMID:18840529 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression
ISO Gossypol analog binds to and affects the activity of BCL2L1 protein
Gossypol results in decreased expression of BCL2L1 protein
CTD PMID:16020667, PMID:18840529 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcl2l11 BCL2 like 11 increases expression ISO Gossypol results in increased expression of BCL2L11 protein CTD PMID:18840529 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
ISO
EXP
[zoledronic acid co-treated with Gossypol] results in increased activity of CASP3 protein
Gossypol results in increased cleavage of CASP3 protein
[Gossypol co-treated with Methyltestosterone co-treated with Ethinyl Estradiol] results in increased expression of CASP3 mRNA
Gossypol results in increased activity of CASP3 protein
CTD PMID:15451339, PMID:18840529, PMID:19825521 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO [zoledronic acid co-treated with Gossypol] results in increased activity of CASP7 protein
Gossypol results in increased activity of CASP7 protein
CTD PMID:19825521 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions
ISO
EXP
Gossypol results in increased cleavage of CASP9 protein
[Gossypol co-treated with Methyltestosterone co-treated with Ethinyl Estradiol] results in increased expression of CASP9 mRNA
CTD PMID:15451339, PMID:18840529 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions
ISO Gossypol results in decreased expression of CCL2 mRNA
zoledronic acid promotes the reaction [Gossypol results in decreased expression of CCL2 mRNA]
CTD PMID:19825521 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cdh2 cadherin 2 decreases expression EXP Gossypol results in decreased expression of CDH2 protein CTD PMID:15082077 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions ISO [zoledronic acid co-treated with Gossypol] results in decreased expression of CXCL1 mRNA CTD PMID:19825521 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO [zoledronic acid co-treated with Gossypol] results in decreased expression of CXCL1 mRNA CTD PMID:19825521 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Ephb4 EPH receptor B4 multiple interactions ISO [zoledronic acid co-treated with Gossypol] results in decreased expression of EPHB4 mRNA CTD PMID:19825521 NCBI chr12:22,393,338...22,418,332
Ensembl chr12:22,393,330...22,417,980
JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP [Gossypol co-treated with Methyltestosterone co-treated with Ethinyl Estradiol] results in increased expression of FAS mRNA CTD PMID:15451339 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression
multiple interactions
ISO Gossypol results in decreased expression of FGF2 mRNA
zoledronic acid promotes the reaction [Gossypol results in decreased expression of FGF2 mRNA]
CTD PMID:19825521 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 decreases expression
multiple interactions
ISO Gossypol results in decreased expression of FGFR3 mRNA
zoledronic acid promotes the reaction [Gossypol results in decreased expression of FGFR3 mRNA]
CTD PMID:19825521 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706
JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression EXP Gossypol results in decreased expression of GJA1 protein CTD PMID:15082077 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases activity
EXP chromium protoporphyrin IX inhibits the reaction [Gossypol results in increased activity of HMOX1 protein] CTD PMID:15027808 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsd17b8 hydroxysteroid (17-beta) dehydrogenase 8 multiple interactions ISO [Gossypol co-treated with NAD] binds to HSD17B8 protein CTD PMID:25526675 NCBI chr20:3,817,212...3,819,316
Ensembl chr20:3,817,179...3,819,235
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein decreases expression
multiple interactions
ISO Gossypol results in decreased expression of ID1 mRNA
zoledronic acid promotes the reaction [Gossypol results in decreased expression of ID1 mRNA]
CTD PMID:19825521 NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718
JBrowse link
G Lama5 laminin subunit alpha 5 multiple interactions ISO [zoledronic acid co-treated with Gossypol] results in decreased expression of LAMA5 mRNA CTD PMID:19825521 NCBI chr 3:175,553,042...175,601,112
Ensembl chr 3:175,553,045...175,601,127
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO Gossypol results in decreased expression of MCL1 protein CTD PMID:18840529, PMID:20587533, PMID:21750559 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mdk midkine decreases expression
multiple interactions
ISO Gossypol results in decreased expression of MDK mRNA
zoledronic acid promotes the reaction [Gossypol results in decreased expression of MDK mRNA]
CTD PMID:19825521 NCBI chr 3:80,841,003...80,843,895
Ensembl chr 3:80,841,005...80,842,916
JBrowse link
G Otc ornithine carbamoyltransferase multiple interactions EXP Gossypol inhibits the reaction [PRL protein results in increased activity of OTC protein]; Gossypol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of OTC protein] CTD PMID:3097147 NCBI chr  X:13,524,804...13,601,074
Ensembl chr  X:13,524,607...13,601,069
JBrowse link
G Pdgfa platelet derived growth factor subunit A multiple interactions ISO [zoledronic acid co-treated with Gossypol] results in decreased expression of PDGFA mRNA CTD PMID:19825521 NCBI chr12:17,734,141...17,756,186
Ensembl chr12:17,734,133...17,755,285
JBrowse link
G Prl prolactin multiple interactions EXP Gossypol inhibits the reaction [PRL protein results in increased activity of OTC protein] CTD PMID:3097147 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Tymp thymidine phosphorylase multiple interactions ISO Gossypol inhibits the reaction [zoledronic acid results in increased expression of TYMP mRNA] CTD PMID:19825521 NCBI chr 7:130,342,481...130,347,845
Ensembl chr 7:130,342,483...130,347,587
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        antispermatogenic agent 564
          gossypol 27
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic aromatic compound 19119
                                  phenols 18112
                                    polyphenol 6657
                                      gossypol 27
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.