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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:gossypol
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Accession:CHEBI:28584 term browser browse the term
Definition:A polyphenol that has formula C30H30O8.
Synonyms:alt_id: CHEBI:24427;   CHEBI:5526
 xref_mesh: MESH:D006072


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gossypol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alas1 5'-aminolevulinate synthase 1 multiple interactions
increases activity
EXP chromium protoporphyrin IX promotes the reaction [Gossypol results in increased activity of ALAS1 protein] CTD PMID:15027808 NCBI chr 8:106,876,514...106,889,852
Ensembl chr 8:106,876,514...106,889,917
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP [Gossypol co-treated with Methyltestosterone co-treated with Ethinyl Estradiol] results in increased expression of BAX mRNA CTD PMID:15451339 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO Gossypol results in increased expression of BBC3 protein CTD PMID:18840529 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression
ISO Gossypol analog binds to and affects the activity of BCL2L1 protein
Gossypol results in decreased expression of BCL2L1 protein
CTD PMID:16020667 PMID:18840529 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bcl2l11 BCL2 like 11 increases expression ISO Gossypol results in increased expression of BCL2L11 protein CTD PMID:18840529 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
ISO
EXP
[zoledronic acid co-treated with Gossypol] results in increased activity of CASP3 protein
Gossypol results in increased cleavage of CASP3 protein
[Gossypol co-treated with Methyltestosterone co-treated with Ethinyl Estradiol] results in increased expression of CASP3 mRNA
Gossypol results in increased activity of CASP3 protein
CTD PMID:15451339 PMID:18840529 PMID:19825521 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO [zoledronic acid co-treated with Gossypol] results in increased activity of CASP7 protein
Gossypol results in increased activity of CASP7 protein
CTD PMID:19825521 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions
ISO
EXP
Gossypol results in increased cleavage of CASP9 protein
[Gossypol co-treated with Methyltestosterone co-treated with Ethinyl Estradiol] results in increased expression of CASP9 mRNA
CTD PMID:15451339 PMID:18840529 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions
ISO Gossypol results in decreased expression of CCL2 mRNA
zoledronic acid promotes the reaction [Gossypol results in decreased expression of CCL2 mRNA]
CTD PMID:19825521 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cdh2 cadherin 2 decreases expression EXP Gossypol results in decreased expression of CDH2 protein CTD PMID:15082077 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions ISO [zoledronic acid co-treated with Gossypol] results in decreased expression of CXCL1 mRNA CTD PMID:19825521 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO [zoledronic acid co-treated with Gossypol] results in decreased expression of CXCL1 mRNA CTD PMID:19825521 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Ephb4 EPH receptor B4 multiple interactions ISO [zoledronic acid co-treated with Gossypol] results in decreased expression of EPHB4 mRNA CTD PMID:19825521 NCBI chr12:19,326,411...19,351,667
Ensembl chr12:19,326,427...19,351,314
JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP [Gossypol co-treated with Methyltestosterone co-treated with Ethinyl Estradiol] results in increased expression of FAS mRNA CTD PMID:15451339 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression
multiple interactions
ISO Gossypol results in decreased expression of FGF2 mRNA
zoledronic acid promotes the reaction [Gossypol results in decreased expression of FGF2 mRNA]
CTD PMID:19825521 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 decreases expression
multiple interactions
ISO Gossypol results in decreased expression of FGFR3 mRNA
zoledronic acid promotes the reaction [Gossypol results in decreased expression of FGFR3 mRNA]
CTD PMID:19825521 NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341
JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression EXP Gossypol results in decreased expression of GJA1 protein CTD PMID:15082077 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases activity
EXP chromium protoporphyrin IX inhibits the reaction [Gossypol results in increased activity of HMOX1 protein] CTD PMID:15027808 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hsd17b8 hydroxysteroid (17-beta) dehydrogenase 8 multiple interactions ISO [Gossypol co-treated with NAD] binds to HSD17B8 protein CTD PMID:25526675 NCBI chr20:4,826,725...4,828,742
Ensembl chr20:4,822,026...4,828,742
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein decreases expression
multiple interactions
ISO Gossypol results in decreased expression of ID1 mRNA
zoledronic acid promotes the reaction [Gossypol results in decreased expression of ID1 mRNA]
CTD PMID:19825521 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
JBrowse link
G Lama5 laminin subunit alpha 5 multiple interactions ISO [zoledronic acid co-treated with Gossypol] results in decreased expression of LAMA5 mRNA CTD PMID:19825521 NCBI chr 3:167,270,296...167,318,370
Ensembl chr 3:167,270,296...167,318,451
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO Gossypol results in decreased expression of MCL1 protein CTD PMID:18840529 PMID:20587533 PMID:21750559 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mdk midkine decreases expression
multiple interactions
ISO Gossypol results in decreased expression of MDK mRNA
zoledronic acid promotes the reaction [Gossypol results in decreased expression of MDK mRNA]
CTD PMID:19825521 NCBI chr 3:77,901,156...77,903,997
Ensembl chr 3:77,901,158...77,903,130
JBrowse link
G Otc ornithine transcarbamylase multiple interactions EXP Gossypol inhibits the reaction [PRL protein results in increased activity of OTC protein]; Gossypol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of OTC protein] CTD PMID:3097147 NCBI chr  X:12,453,834...12,529,954
Ensembl chr  X:12,453,834...12,566,918
JBrowse link
G Pdgfa platelet derived growth factor subunit A multiple interactions ISO [zoledronic acid co-treated with Gossypol] results in decreased expression of PDGFA mRNA CTD PMID:19825521 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497
JBrowse link
G Prl prolactin multiple interactions EXP Gossypol inhibits the reaction [PRL protein results in increased activity of OTC protein] CTD PMID:3097147 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Tymp thymidine phosphorylase multiple interactions ISO Gossypol inhibits the reaction [zoledronic acid results in increased expression of TYMP mRNA] CTD PMID:19825521 NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      application 19471
        antispermatogenic agent 1114
          gossypol 27
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic molecule 19560
                              organic cyclic compound 19351
                                organic aromatic compound 19176
                                  phenols 18146
                                    polyphenol 6717
                                      gossypol 27
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