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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:piperazine
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Accession:CHEBI:28568 term browser browse the term
Definition:An azacycloalkane that consists of a six-membered ring containing two nitrogen atoms at opposite positions.
Synonyms:related_synonym: 1,4-diazacyclohexane;   1,4-diethylenediamine;   1,4-piperazine;   Diethylenediamine;   Formula=C4H10N2;   InChI=1S/C4H10N2/c1-2-6-4-3-5-1/h5-6H,1-4H2;   InChIKey=GLUUGHFHXGJENI-UHFFFAOYSA-N;   Piperazin;   SMILES=C1CNCCN1;   Vermizine (TN);   hexahydro-1,4-diazine
 alt_id: CHEBI:26143;   CHEBI:8235
 xref: Beilstein:102555;   CAS:110-85-0;   CAS:142-88-1;   Chemspider:13835459;   DrugBank:DB00592;   Drug_Central:2188;   FooDB:FDB012189;   Gmelin:25695;   HMDB:HMDB0014730;   KEGG:C07973;   KEGG:D00807;   KEGG:D02145
 xref_mesh: MESH:C034930
 xref: MetaCyc:PIPERAZINE;   PDBeChem:PZE;   PMID:15017096;   PMID:16987490;   PMID:24201896;   PMID:28842264;   PMID:29438107;   PMID:32912125;   PMID:33336346;   PMID:33751807;   PMID:9265850;   Pesticides:piperazine;   Reaxys:102555;   VSDB:1781;   Wikipedia:Piperazine
 cyclic_relationship: is_conjugate_base_of CHEBI:136874



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piperazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator increases expression EXP Piperazine analog results in increased expression of BAX protein CTD PMID:28874085 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP Piperazine analog results in decreased expression of BCL2 protein CTD PMID:28874085 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CASP3 caspase 3 increases cleavage EXP Piperazine analog results in increased cleavage of CASP3 protein CTD PMID:28874085 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CAT catalase increases activity EXP Piperazine analog results in increased activity of CAT protein CTD PMID:28874085 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G IL2 interleukin 2 decreases expression EXP piperazine analog results in decreased expression of IL2 mRNA CTD PMID:11859000 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G SOD1 superoxide dismutase 1 increases activity EXP Piperazine analog results in increased activity of SOD1 protein CTD PMID:28874085 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
JBrowse link
G TH tyrosine hydroxylase decreases expression EXP Piperazine analog results in decreased expression of TH protein CTD PMID:28874085 NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26040
    role 25956
      application 25180
        pharmaceutical 24551
          drug 24548
            antiinfective agent 17269
              antiparasitic agent 10648
                anthelminthic drug 5685
                  piperazine 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 26040
    subatomic particle 26015
      composite particle 26015
        hadron 26015
          baryon 26015
            nucleon 26015
              atomic nucleus 26015
                atom 26015
                  main group element atom 25840
                    p-block element atom 25840
                      carbon group element atom 25441
                        carbon atom 25399
                          organic molecular entity 25399
                            organic molecule 25228
                              organic cyclic compound 24279
                                organic heterocyclic compound 22322
                                  organic heteromonocyclic compound 19239
                                    piperazines 4531
                                      piperazine 7
paths to the root