CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: piperazine
Accession: CHEBI:28568
browse the term
Definition: An azacycloalkane that consists of a six-membered ring containing two nitrogen atoms at opposite positions.
Synonyms: related_synonym: 1,4-diazacyclohexane; 1,4-diethylenediamine; 1,4-piperazine; Diethylenediamine; Formula=C4H10N2; InChI=1S/C4H10N2/c1-2-6-4-3-5-1/h5-6H,1-4H2; InChIKey=GLUUGHFHXGJENI-UHFFFAOYSA-N; Piperazin; SMILES=C1CNCCN1; Vermizine (TN); hexahydro-1,4-diazine
alt_id: CHEBI:26143; CHEBI:8235
xref: Beilstein:102555; CAS:110-85-0; CAS:142-88-1; Chemspider:13835459; DrugBank:DB00592; Drug_Central:2188; FooDB:FDB012189; Gmelin:25695; HMDB:HMDB0014730; KEGG:C07973; KEGG:D00807; KEGG:D02145
xref_mesh: MESH:C034930
xref: MetaCyc:PIPERAZINE; PDBeChem:PZE; PMID:15017096; PMID:16987490; PMID:24201896; PMID:28842264; PMID:29438107; PMID:32912125; PMID:33336346; PMID:33751807; PMID:9265850; Pesticides:piperazine; Reaxys:102555; VSDB:1781; Wikipedia:Piperazine
cyclic_relationship: is_conjugate_base_of CHEBI:136874
G
BAX
BCL2 associated X, apoptosis regulator
increases expression
EXP
Piperazine analog results in increased expression of BAX protein
CTD
PMID:28874085
NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
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BCL2
BCL2 apoptosis regulator
decreases expression
EXP
Piperazine analog results in decreased expression of BCL2 protein
CTD
PMID:28874085
NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
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CASP3
caspase 3
increases cleavage
EXP
Piperazine analog results in increased cleavage of CASP3 protein
CTD
PMID:28874085
NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
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CAT
catalase
increases activity
EXP
Piperazine analog results in increased activity of CAT protein
CTD
PMID:28874085
NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
G
IL2
interleukin 2
decreases expression
EXP
piperazine analog results in decreased expression of IL2 mRNA
CTD
PMID:11859000
NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
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SOD1
superoxide dismutase 1
increases activity
EXP
Piperazine analog results in increased activity of SOD1 protein
CTD
PMID:28874085
NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
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TH
tyrosine hydroxylase
decreases expression
EXP
Piperazine analog results in decreased expression of TH protein
CTD
PMID:28874085
NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815
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