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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:selenocystine
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Accession:CHEBI:28553 term browser browse the term
Definition:A diselenide that has formula C6H12N2O4Se2.
Synonyms:exact_synonym: 3,3'-diselane-1,2-diylbis(2-aminopropanoic acid)
 related_synonym: 3,3'-Diselenobisalanine;   3,3'-Diselenodialanine;   Formula=C6H12N2O4Se2;   InChI=1S/C6H12N2O4Se2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12);   InChIKey=JULROCUWKLNBSN-UHFFFAOYSA-N;   SMILES=NC(C[Se][Se]CC(N)C(O)=O)C(O)=O
 alt_id: CHEBI:26633;   CHEBI:9095
 xref: Beilstein:1969559;   CAS:1464-43-3;   KEGG:C05704
 xref_mesh: MESH:C009226



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selenocystine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO selenocystine results in increased expression of BAX protein CTD PMID:35863474 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO selenocystine results in decreased expression of BCL2 protein CTD PMID:35863474 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression
ISO 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [selenocystine results in decreased expression of CASP3 protein] CTD PMID:35863474 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 decreases expression ISO selenocystine results in decreased expression of CASP8 protein CTD PMID:35863474 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 decreases expression ISO selenocystine results in decreased expression of CASP9 protein CTD PMID:35863474 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase decreases expression ISO selenocystine results in decreased expression of CAT protein CTD PMID:35863474 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression
ISO NFE2L2 mutant form inhibits the reaction [selenocystine results in increased expression of GCLC mRNA] CTD PMID:22807314 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G H2ax H2A.X variant histone increases phosphorylation ISO selenocystine results in increased phosphorylation of H2AX protein CTD PMID:35863474 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO selenocystine inhibits the reaction [Methylmercury Compounds results in decreased activity of MAPK1 protein] CTD PMID:23838314 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO selenocystine inhibits the reaction [Methylmercury Compounds results in decreased activity of MAPK3 protein] CTD PMID:23838314 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
affects localization
ISO NFE2L2 mutant form inhibits the reaction [selenocystine results in increased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [selenocystine results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [selenocystine results in increased expression of TXNRD1 mRNA]
selenocystine affects the localization of NFE2L2 protein
CTD PMID:22807314 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
affects expression
increases expression
ISO NFE2L2 mutant form inhibits the reaction [selenocystine results in increased expression of NQO1 mRNA]
selenocystine affects the expression of NQO1 mRNA
selenocystine results in increased expression of NQO1 protein
CTD PMID:22807314 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Slc3a1 solute carrier family 3 member 1 increases uptake ISO SLC3A1 protein results in increased uptake of selenocystine CTD PMID:18845132 NCBI chr 6:9,608,169...9,641,881
Ensembl chr 6:9,608,178...9,641,907
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression ISO selenocystine results in decreased expression of SOD1 protein CTD PMID:35863474 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 decreases expression ISO selenocystine results in decreased expression of SOD2 protein CTD PMID:35863474 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases response to substance
multiple interactions
increases expression
ISO TXNRD1 protein results in decreased susceptibility to selenocystine
NFE2L2 mutant form inhibits the reaction [selenocystine results in increased expression of TXNRD1 mRNA]
selenocystine results in increased expression of TXNRD1 mRNA; selenocystine results in increased expression of TXNRD1 protein
CTD PMID:20920480 PMID:22807314 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Xpa XPA, DNA damage recognition and repair factor multiple interactions
decreases activity
ISO selenocystine inhibits the reaction [Zinc binds to XPA protein]
selenocystine results in decreased activity of XPA protein
CTD PMID:15265038 NCBI chr 5:60,431,673...60,475,726
Ensembl chr 5:60,431,673...60,475,726
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    chemical entity 19916
      atom 19916
        nonmetal atom 19852
          selenium atom 3252
            selenium molecular entity 3252
              diselenide 17
                selenocystine 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic group 18995
                              organic divalent group 18969
                                organodiyl group 18969
                                  carbonyl group 18922
                                    carbonyl compound 18922
                                      carboxylic acid 18646
                                        amino acid 15961
                                          alpha-amino acid 13870
                                            selenocysteine 94
                                              selenocystine 17
paths to the root