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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:selenocystine
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Accession:CHEBI:28553 term browser browse the term
Definition:A diselenide that has formula C6H12N2O4Se2.
Synonyms:exact_synonym: 3,3'-diselane-1,2-diylbis(2-aminopropanoic acid)
 related_synonym: 3,3'-Diselenobisalanine;   3,3'-Diselenodialanine;   Formula=C6H12N2O4Se2;   InChI=1S/C6H12N2O4Se2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12);   InChIKey=JULROCUWKLNBSN-UHFFFAOYSA-N;   SMILES=NC(C[Se][Se]CC(N)C(O)=O)C(O)=O
 alt_id: CHEBI:26633;   CHEBI:9095
 xref: Beilstein:1969559;   CAS:1464-43-3;   KEGG:C05704
 xref_mesh: MESH:C009226


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selenocystine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression
ISO NFE2L2 mutant form inhibits the reaction [selenocystine results in increased expression of GCLC mRNA] CTD PMID:22807314 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO selenocystine inhibits the reaction [Methylmercury Compounds results in decreased activity of MAPK1 protein] CTD PMID:23838314 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO selenocystine inhibits the reaction [Methylmercury Compounds results in decreased activity of MAPK3 protein] CTD PMID:23838314 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
affects localization
ISO NFE2L2 mutant form inhibits the reaction [selenocystine results in increased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [selenocystine results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [selenocystine results in increased expression of TXNRD1 mRNA]
selenocystine affects the localization of NFE2L2 protein
CTD PMID:22807314 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
affects expression
ISO NFE2L2 mutant form inhibits the reaction [selenocystine results in increased expression of NQO1 mRNA]
selenocystine results in increased expression of NQO1 protein
selenocystine affects the expression of NQO1 mRNA
CTD PMID:22807314 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Slc3a1 solute carrier family 3 member 1 increases uptake ISO SLC3A1 protein results in increased uptake of selenocystine CTD PMID:18845132 NCBI chr 6:9,608,169...9,641,881
Ensembl chr 6:9,608,178...9,641,907
JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases response to substance
increases expression
multiple interactions
ISO TXNRD1 protein results in decreased susceptibility to selenocystine
selenocystine results in increased expression of TXNRD1 mRNA; selenocystine results in increased expression of TXNRD1 protein
NFE2L2 mutant form inhibits the reaction [selenocystine results in increased expression of TXNRD1 mRNA]
CTD PMID:20920480 PMID:22807314 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Xpa XPA, DNA damage recognition and repair factor multiple interactions
decreases activity
ISO selenocystine inhibits the reaction [Zinc binds to XPA protein]
selenocystine results in decreased activity of XPA protein
CTD PMID:15265038 NCBI chr 5:60,431,673...60,476,438
Ensembl chr 5:60,431,673...60,475,726
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    chemical entity 19812
      atom 19811
        nonmetal atom 19698
          selenium atom 3130
            selenium molecular entity 3130
              diselenide 8
                selenocystine 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        amino acid 14873
                                          alpha-amino acid 12852
                                            selenocysteine 87
                                              selenocystine 8
paths to the root