CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: valinomycin
Accession: CHEBI:28545
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Definition: A twelve-membered cyclodepsipeptide composed of three repeating D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl units joined in sequence. An antibiotic found in several Streptomyces strains.
Synonyms: exact_synonym: (3R,6R,9S,12S,15R,18R,21S,24S,27R,30R,33S,36S)-3,6,9,15,18,21,27,30,33-nonaisopropyl-12,24,36-trimethyl-1,7,13,19,25,31-hexaoxa-4,10,16,22,28,34-hexaazacyclohexatriacontane-2,5,8,11,14,17,20,23,26,29,32,35-dodecone
related_synonym: Cyclic(D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl); Formula=C54H90N6O18; InChI=1S/C54H90N6O18/c1-22(2)34-49(67)73-31(19)43(61)55-38(26(9)10)53(71)77-41(29(15)16)47(65)59-36(24(5)6)51(69)75-33(21)45(63)57-39(27(11)12)54(72)78-42(30(17)18)48(66)60-35(23(3)4)50(68)74-32(20)44(62)56-37(25(7)8)52(70)76-40(28(13)14)46(64)58-34/h22-42H,1-21H3,(H,55,61)(H,56,62)(H,57,63)(H,58,64)(H,59,65)(H,60,66)/t31-,32-,33-,34+,35+,36+,37-,38-,39-,40+,41+,42+/m0/s1; InChIKey=FCFNRCROJUBPLU-DNDCDFAISA-N; SMILES=CC(C)[C@@H]1NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC1=O)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C; cyclo[-D-O-Val-D-Val-L-O-Ala-L-Val]3
alt_id: CHEBI:27269; CHEBI:66347; CHEBI:9924
xref: Beilstein:78657; CAS:2001-95-8; KEGG:C06684
xref_mesh: MESH:D014634
xref: PMID:10603383; PMID:18633285; PMID:19347893; PMID:22683555; PMID:7590182; Reaxys:78657; Wikipedia:Valinomycin
G
Abcb11
ATP binding cassette subfamily B member 11
decreases activity
ISO
Valinomycin results in decreased activity of ABCB11 protein
CTD
PMID:12739759 PMID:20829430 PMID:23956101
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Casp3
caspase 3
increases cleavage increases activity
ISO
Valinomycin results in increased cleavage of CASP3 protein Valinomycin results in increased activity of CASP3 protein
CTD
PMID:18926839 PMID:28157593
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cycs
cytochrome c, somatic
affects localization
ISO
Valinomycin affects the localization of CYCS protein
CTD
PMID:19193189
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
G
Esr1
estrogen receptor 1
multiple interactions
ISO
Valinomycin binds to and results in decreased activity of ESR1 protein
CTD
PMID:25752796
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Esr2
estrogen receptor 2
multiple interactions
ISO
Valinomycin binds to and results in decreased activity of ESR2 protein
CTD
PMID:25752796
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
G
Nnat
neuronatin
decreases response to substance
EXP
NNAT protein results in decreased susceptibility to Valinomycin
CTD
PMID:12101027
NCBI chr 3:146,225,941...146,228,868
Ensembl chr 3:146,226,407...146,228,834
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Slc17a7
solute carrier family 17 member 7
multiple interactions
EXP
Valinomycin inhibits the reaction [SLC17A7 protein results in increased uptake of Excitatory Amino Acid Agents]
CTD
PMID:15860731
NCBI chr 1:95,649,709...95,661,591
Ensembl chr 1:95,649,745...95,661,588
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Slc18a2
solute carrier family 18 member A2
multiple interactions
EXP
Valinomycin promotes the reaction [SLC18A2 protein results in increased uptake of Serotonin]
CTD
PMID:18287335
NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325
G
Thra
thyroid hormone receptor alpha
multiple interactions
ISO
Valinomycin binds to and results in decreased activity of THRA protein
CTD
PMID:25752796
NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
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