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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1,2-dibromoethane
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Accession:CHEBI:28534 term browser browse the term
Definition:A bromoalkane that is ethane carrying bromo substituents at positions 1 and 2. It is produced by marine algae.
Synonyms:related_synonym: DBE;   EDB;   Ethylene dibromide;   Formula=C2H4Br2;   InChI=1S/C2H4Br2/c3-1-2-4/h1-2H2;   InChIKey=PAAZPARNPHGIKF-UHFFFAOYSA-N;   SMILES=BrCCBr;   alpha,beta-dibromoethane;   alpha,omega-dibromoethane;   ethylene bromide;   sym-Dibromoethane
 alt_id: CHEBI:18880;   CHEBI:496
 xref: Beilstein:605266;   CAS:106-93-4;   Gmelin:1913;   HMDB:HMDB0060334;   KEGG:C11088
 xref_mesh: MESH:D015946
 xref: MetaCyc:12-DIBROMOETHANE;   PMID:10088182;   PMID:11312844;   PPDB:1484;   Reaxys:605266;   Wikipedia:1\,2-Dibromoethane



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1,2-dibromoethane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsm1 acyl-CoA synthetase medium-chain family member 1 increases expression ISO Ethylene Dibromide results in increased expression of ACSM1 mRNA CTD PMID:17311802 NCBI chr 1:173,985,715...174,020,565
Ensembl chr 1:173,984,672...174,025,495
JBrowse link
G Arid3a AT-rich interaction domain 3A increases expression ISO Ethylene Dibromide results in increased expression of ARID3A mRNA CTD PMID:15612046 NCBI chr 7:9,755,291...9,781,260
Ensembl chr 7:9,755,294...9,780,599
JBrowse link
G Ces1d carboxylesterase 1D increases expression ISO Ethylene Dibromide results in increased expression of CES1 mRNA CTD PMID:17311802 NCBI chr19:13,873,490...13,912,035 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing
increases oxidation
ISO CYP2E1 protein results in increased metabolism of Ethylene Dibromide
CYP2E1 protein results in increased oxidation of Ethylene Dibromide
CTD PMID:1664256 PMID:10841534 PMID:18350910 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Ecm1 extracellular matrix protein 1 decreases expression ISO Ethylene Dibromide results in decreased expression of ECM1 mRNA CTD PMID:15612046 NCBI chr 2:183,287,491...183,292,729
Ensembl chr 2:183,287,322...183,292,671
JBrowse link
G Ephx1 epoxide hydrolase 1 decreases expression ISO Ethylene Dibromide results in decreased expression of EPHX1 mRNA CTD PMID:17311802 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Fgfrl1 fibroblast growth factor receptor-like 1 decreases expression ISO Ethylene Dibromide results in decreased expression of FGFRL1 protein CTD PMID:22434383 NCBI chr14:1,009,863...1,022,620
Ensembl chr14:1,009,786...1,021,928
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 increases activity
multiple interactions
ISO Ethylene Dibromide results in increased activity of GGT1 protein
Phentolamine inhibits the reaction [Ethylene Dibromide results in increased activity of GGT1 protein]; Phenylephrine promotes the reaction [Ethylene Dibromide results in increased activity of GGT1 protein]
CTD PMID:12628311 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
JBrowse link
G Gstt1 glutathione S-transferase theta 1 multiple interactions
increases activity
affects response to substance
increases glutathionylation
ISO
EXP
GSTT1 gene SNP inhibits the reaction [GSTT1 protein results in increased glutathionylation of Ethylene Dibromide]; GSTT1 protein affects the metabolism of and results in increased activity of Ethylene Dibromide
GSTT1 protein results in increased activity of Ethylene Dibromide
GSTT1 protein results in increased metabolism of and results in increased activity of Ethylene Dibromide
GSTT1 protein affects the susceptibility to Ethylene Dibromide
CTD PMID:8565128 PMID:10413528 PMID:12505322 PMID:12902151 PMID:19664997 More... NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
JBrowse link
G Gtf2ird1 GTF2I repeat domain containing 1 decreases expression ISO Ethylene Dibromide results in decreased expression of GTF2IRD1 protein CTD PMID:22434383 NCBI chr12:22,254,113...22,361,052
Ensembl chr12:22,254,221...22,361,040
JBrowse link
G Krt10 keratin 10 decreases expression ISO Ethylene Dibromide results in decreased expression of KRT10 protein CTD PMID:22434383 NCBI chr10:84,338,695...84,343,279
Ensembl chr10:84,338,706...84,343,701
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 decreases expression ISO Ethylene Dibromide results in decreased expression of LEF1 mRNA CTD PMID:15612046 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
JBrowse link
G Mapk10 mitogen activated protein kinase 10 increases expression ISO Ethylene Dibromide results in increased expression of MAPK10 mRNA CTD PMID:15612046 NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase multiple interactions
increases response to substance
affects binding
ISO Ethylene Dibromide binds to and results in decreased activity of MGMT protein; MGMT protein affects the metabolism of and results in increased activity of Ethylene Dibromide; MGMT protein results in increased activity of and results in increased susceptibility to Ethylene Dibromide
MGMT protein results in increased susceptibility to Ethylene Dibromide
Ethylene Dibromide binds to MGMT protein
CTD PMID:10894884 PMID:12151404 PMID:14645247 PMID:17226938 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity ISO Ethylene Dibromide results in increased activity of NFE2L2 protein CTD PMID:30114225 PMID:30203046 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Ethylene Dibromide results in increased expression of NQO1 mRNA CTD PMID:17311802 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Odc1 ornithine decarboxylase 1 increases activity EXP Ethylene Dibromide results in increased activity of ODC1 protein CTD PMID:3801022 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
JBrowse link
G Pard3 par-3 family cell polarity regulator increases expression ISO Ethylene Dibromide results in increased expression of PARD3 protein CTD PMID:22434383 NCBI chr19:55,080,282...55,630,111
Ensembl chr19:55,080,282...55,629,778
JBrowse link
G Pld3 phospholipase D family, member 3 increases expression ISO Ethylene Dibromide results in increased expression of PLD3 mRNA CTD PMID:15612046 NCBI chr 1:82,821,863...82,844,280
Ensembl chr 1:82,821,875...82,844,072
JBrowse link
G Ppp1r1c protein phosphatase 1, regulatory (inhibitor) subunit 1C decreases expression ISO Ethylene Dibromide results in decreased expression of PPP1R1C mRNA CTD PMID:15612046 NCBI chr 3:64,616,700...64,719,696
Ensembl chr 3:64,616,700...64,724,104
JBrowse link
G Rad18 RAD18 E3 ubiquitin protein ligase decreases expression ISO Ethylene Dibromide results in decreased expression of RAD18 protein CTD PMID:22434383 NCBI chr 4:145,735,654...145,821,102
Ensembl chr 4:145,735,654...145,821,069
JBrowse link
G Slc9a3r1 SLC9A3 regulator 1 increases expression ISO Ethylene Dibromide results in increased expression of SLC9A3R1 protein CTD PMID:22434383 NCBI chr10:100,403,189...100,420,290
Ensembl chr10:100,403,069...100,420,598
JBrowse link
G St7l suppression of tumorigenicity 7-like decreases expression ISO Ethylene Dibromide results in decreased expression of ST7L mRNA CTD PMID:15612046 NCBI chr 2:192,364,594...192,434,414
Ensembl chr 2:192,364,594...192,487,190
JBrowse link
G Tcfl5 transcription factor like 5 increases expression ISO Ethylene Dibromide results in increased expression of TCFL5 mRNA CTD PMID:15612046 NCBI chr 3:167,734,471...167,754,174
Ensembl chr 3:167,734,473...167,754,282
JBrowse link
G Tnf tumor necrosis factor increases expression EXP Ethylene dibromide increases expression of Tnf mRNA in liver RGD PMID:7943184 RGD:14995476 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp63 tumor protein p63 increases expression ISO Ethylene Dibromide results in increased expression of TRP63 mRNA CTD PMID:15612046 NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398
JBrowse link
G Tph1 tryptophan hydroxylase 1 increases expression ISO Ethylene Dibromide results in increased expression of TPH1 mRNA CTD PMID:15612046 NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344
JBrowse link
G Trpv2 transient receptor potential cation channel, subfamily V, member 2 increases expression ISO Ethylene Dibromide results in increased expression of TRPV2 mRNA CTD PMID:15612046 NCBI chr10:47,265,524...47,294,263
Ensembl chr10:47,272,931...47,294,260
JBrowse link

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  CHEBI ontology 19823
    role 19773
      application 19486
        pesticide 17133
          fumigant 1007
            1,2-dibromoethane 28
Path 2
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  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    main group molecular entity 19720
                      s-block molecular entity 19502
                        hydrogen molecular entity 19495
                          hydrides 18855
                            organic hydride 18361
                              organic fundamental parent 18361
                                hydrocarbon 18074
                                  halohydrocarbon 14069
                                    haloalkane 11708
                                      bromoalkane 88
                                        1,2-dibromoethane 28
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