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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:kaempferol
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Accession:CHEBI:28499 term browser browse the term
Definition:A tetrahydroxyflavone in which the four hydroxy groups are located at positions 3, 5, 7 and 4'. Acting as an antioxidant by reducing oxidative stress, it is currently under consideration as a possible cancer treatment.
Synonyms:related_synonym: 3,4',5,7-Tetrahydroxyflavone;   3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one;   4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-5,7,4'-Trihydroxyflavonol;   5,7,4'-trihydroxyflavonol;   C.I. 75640;   Formula=C15H10O6;   InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H;   InChIKey=IYRMWMYZSQPJKC-UHFFFAOYSA-N;   Indigo yellow;   Kaempherol;   Kampherol;   Kempferol;   Nimbecetin;   Pelargidenolon;   Populnetin;   Rhamnolutein;   Rhamnolutin;   Robigenin;   SMILES=Oc1ccc(cc1)-c1oc2cc(O)cc(O)c2c(=O)c1O;   Swartziol;   Trifolitin;   campherol
 alt_id: CHEBI:24944;   CHEBI:43598;   CHEBI:6100
 xref: Beilstein:304401;   CAS:520-18-3;   DrugBank:DB01852;   HMDB:HMDB0005801;   KEGG:C05903;   KNApSAcK:C00004565;   LINCS:LSM-5304;   LIPID_MAPS_instance:LMPK12110003
 xref_mesh: MESH:C006552
 xref: MetaCyc:CPD1F-90;   PDBeChem:KMP;   PMID:12592675;   PMID:15234754;   PMID:17426744;   PMID:17551714;   PMID:28166217;   Reaxys:304401;   Wikipedia:kaempferol
 cyclic_relationship: is_conjugate_acid_of CHEBI:58573


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kaempferol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
decreases expression
increases activity
multiple interactions		 ISO ABCB1 protein results in increased transport of kaempferol
kaempferol results in decreased expression of ABCB1 mRNA; kaempferol results in decreased expression of ABCB1 protein
kaempferol results in increased activity of ABCB1 protein
[Verapamil co-treated with kaempferol] results in decreased expression of ABCB1 mRNA; [Verapamil co-treated with kaempferol] results in decreased expression of ABCB1 protein; kaempferol inhibits the reaction [[ABCB1 protein results in decreased susceptibility to Doxorubicin] promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA]]; kaempferol inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; kaempferol inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; kaempferol inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; Verapamil promotes the reaction [kaempferol results in increased activity of ABCB1 protein]		 CTD PMID:15266218 PMID:15969930 PMID:20438634 PMID:34217736 PMID:35063459 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity
increases activity
multiple interactions
affects activity		 ISO kaempferol results in decreased activity of ABCC1 protein
kaempferol results in increased activity of ABCC1 protein
kaempferol affects the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; kaempferol inhibits the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]
kaempferol affects the activity of ABCC1 protein		 CTD PMID:11306701 PMID:15670588 PMID:15796199 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Ache acetylcholinesterase multiple interactions EXP kaempferol inhibits the reaction [Chlorpyrifos results in decreased activity of ACHE protein] CTD PMID:30497708 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression ISO kaempferol results in decreased expression of ACTA2 protein CTD PMID:26683311 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Afp alpha-fetoprotein affects binding
decreases expression		 EXP
ISO		 kaempferol binds to AFP protein
kaempferol results in decreased expression of AFP protein		 CTD PMID:23013281 PMID:25349334 PMID:26683311 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Ahr aryl hydrocarbon receptor affects binding
multiple interactions
increases activity		 ISO kaempferol binds to AHR protein
kaempferol inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1B1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1B1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AHR protein]
kaempferol results in increased activity of AHR protein
kaempferol inhibits the reaction [beta-Naphthoflavone promotes the reaction [AHR protein binds to ARNT protein]]; kaempferol inhibits the reaction [beta-Naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [AHR protein binds to AIP protein]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of AHR protein]		 CTD PMID:10359656 PMID:14644660 PMID:17012224 PMID:19034627 PMID:19794518 More... NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Aip aryl-hydrocarbon receptor-interacting protein multiple interactions ISO kaempferol inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [AHR protein binds to AIP protein]] CTD PMID:20450880 NCBI chr 1:201,408,002...201,419,220
Ensembl chr 1:201,407,288...201,419,122 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation		 ISO
EXP		 kaempferol inhibits the reaction [HGF protein results in increased phosphorylation of AKT1 protein]; kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of AKT1 protein]
kaempferol inhibits the reaction [INS1 protein results in increased activity of AKT1 protein]
kaempferol results in decreased phosphorylation of AKT1 protein
[kaempferol co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]; kaempferol inhibits the reaction [Oxygen deficiency results in increased expression of AKT1 mRNA]; kaempferol inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]		 CTD PMID:18591783 PMID:19244381 PMID:20438634 PMID:36940862 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type decreases activity
multiple interactions		 ISO kaempferol results in decreased activity of ALOX12 protein
kaempferol inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid]		 CTD PMID:17027136 NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions ISO kaempferol inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4] CTD PMID:18096136 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Apoe apolipoprotein E multiple interactions ISO kaempferol inhibits the reaction [APOE affects the expression of CD44 mRNA]; kaempferol inhibits the reaction [APOE affects the expression of CD44 protein]; kaempferol inhibits the reaction [APOE affects the expression of SPP1 mRNA]; kaempferol inhibits the reaction [APOE affects the expression of SPP1 protein] CTD PMID:22005275 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G App amyloid beta precursor protein multiple interactions EXP kaempferol inhibits the reaction [APP protein binds to APP protein] CTD PMID:17323972 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Ar androgen receptor multiple interactions ISO kaempferol binds to and results in increased activity of AR protein; kaempferol inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein] CTD PMID:29162470 PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO kaempferol inhibits the reaction [beta-Naphthoflavone promotes the reaction [AHR protein binds to ARNT protein]]; kaempferol inhibits the reaction [beta-Naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]
kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein]		 CTD PMID:17012224 PMID:20450880 PMID:20846786 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580 		JBrowse link
G Atm ATM serine/threonine kinase multiple interactions
increases phosphorylation		 ISO Caffeine inhibits the reaction [kaempferol results in increased phosphorylation of ATM protein] CTD PMID:19028473 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G B3galt5 Beta-1,3-galactosyltransferase 5 decreases expression ISO kaempferol results in decreased expression of B3GALT5 protein CTD PMID:22906706 NCBI chr11:35,584,273...35,630,922
Ensembl chr11:35,585,220...35,630,917 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions EXP [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of BAD protein CTD PMID:36049518 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO
EXP		 kaempferol results in increased expression of BAX protein
kaempferol inhibits the reaction [propacetamol results in increased expression of BAX protein]
kaempferol inhibits the reaction [Doxorubicin promotes the reaction [TP53 protein binds to BAX promoter]]; kaempferol inhibits the reaction [Doxorubicin results in increased expression of BAX mRNA]; kaempferol inhibits the reaction [Oxygen deficiency results in decreased expression of BAX protein]		 CTD PMID:19028473 PMID:22155320 PMID:29574133 PMID:36940862 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions
increases expression		 ISO Caffeine inhibits the reaction [kaempferol results in increased expression of BBC3 protein]; kaempferol promotes the reaction [BBC3 protein binds to BCL2L1 protein]; TP53 protein affects the reaction [kaempferol promotes the reaction [BBC3 protein binds to BCL2L1 protein]] CTD PMID:19028473 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO
EXP		 kaempferol results in decreased expression of BCL2 protein
kaempferol inhibits the reaction [Oxygen deficiency results in increased expression of BCL2 protein]		 CTD PMID:19028473 PMID:36940862 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions ISO kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2A1 mRNA] CTD PMID:20438634 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO kaempferol promotes the reaction [BBC3 protein binds to BCL2L1 protein]; TP53 protein affects the reaction [kaempferol promotes the reaction [BBC3 protein binds to BCL2L1 protein]] CTD PMID:19028473 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression ISO kaempferol results in increased expression of BMP2 mRNA; kaempferol results in increased expression of BMP2 protein CTD PMID:23989061 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Bmp4 bone morphogenetic protein 4 increases expression ISO kaempferol results in increased expression of BMP4 mRNA CTD PMID:23989061 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Calcr calcitonin receptor multiple interactions ISO kaempferol inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA] CTD PMID:16434028 NCBI chr 4:31,661,270...31,736,392
Ensembl chr 4:31,661,273...31,736,392 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO kaempferol inhibits the reaction [IL32 protein results in increased expression of and results in increased activity of CASP1 protein] CTD PMID:28711657 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage		 EXP
ISO		 kaempferol inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]; kaempferol inhibits the reaction [Oxygen deficiency results in increased cleavage of CASP3 protein]; kaempferol promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of CASP3 protein]]
kaempferol inhibits the reaction [propacetamol results in increased cleavage of CASP3 protein]; kaempferol inhibits the reaction [Rotenone results in increased cleavage of CASP3 protein]
kaempferol results in increased cleavage of CASP3 protein
3',4'-dihydroxyflavone analog inhibits the reaction [kaempferol results in increased cleavage of CASP3 protein]; kaempferol inhibits the reaction [Rotenone results in increased cleavage of CASP3 protein]		 CTD PMID:16014620 PMID:18331776 PMID:19028473 PMID:19397994 PMID:20594614 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions		 ISO
EXP		 kaempferol results in increased cleavage of CASP9 protein
[kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of CASP9 protein
kaempferol inhibits the reaction [Rotenone results in increased cleavage of CASP9 protein]		 CTD PMID:18331776 PMID:20594614 PMID:36049518 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions EXP
ISO		 kaempferol inhibits the reaction [Chlorpyrifos results in decreased activity of CAT protein]; kaempferol inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; kaempferol inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]
kaempferol inhibits the reaction [propacetamol results in decreased activity of CAT protein]		 CTD PMID:22155320 PMID:29574133 PMID:30372826 PMID:30497708 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cckar cholecystokinin A receptor multiple interactions EXP kaempferol inhibits the reaction [8-sulfocholecystokinin octapeptide results in increased activity of CCKAR protein] CTD PMID:24630973 NCBI chr14:57,292,397...57,300,747
Ensembl chr14:57,292,397...57,300,747 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP		 kaempferol inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]; kaempferol inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; kaempferol inhibits the reaction [TNF protein results in increased secretion of CCL2 protein]
kaempferol inhibits the reaction [Oxaliplatin results in increased expression of CCL2 mRNA]
kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCL2 mRNA]		 CTD PMID:16434028 PMID:20438634 PMID:31306686 PMID:35574720 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO [Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in decreased expression of CCL5 mRNA CTD PMID:16797527 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccn5 cellular communication network factor 5 increases expression
multiple interactions		 ISO kaempferol results in increased expression of CCN5 mRNA
ESR1 protein inhibits the reaction [kaempferol results in increased expression of CCN5 mRNA]		 CTD PMID:23384675 NCBI chr 3:152,491,247...152,502,639
Ensembl chr 3:152,491,220...152,502,636 		JBrowse link
G Ccna2 cyclin A2 multiple interactions EXP [Oxygen deficiency co-treated with kaempferol co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased expression of CCNA2 protein; [Oxygen deficiency co-treated with kaempferol] results in increased expression of CCNA2 protein; kaempferol inhibits the reaction [Oxygen deficiency results in increased expression of CCNA2 protein] CTD PMID:36940862 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO kaempferol results in decreased expression of CCNB1 mRNA; kaempferol results in decreased expression of CCNB1 protein CTD PMID:18331776 PMID:19397994 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO
EXP		 kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCND1 mRNA]
[kaempferol co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [Oxygen deficiency results in increased expression of CCND1 protein]; kaempferol inhibits the reaction [Oxygen deficiency results in increased expression of CCND1 mRNA]; kaempferol inhibits the reaction [Oxygen deficiency results in increased expression of CCND1 protein]		 CTD PMID:20438634 PMID:36940862 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cd14 CD14 molecule multiple interactions ISO kaempferol inhibits the reaction [IL32 protein results in increased expression of CD14 mRNA]; kaempferol inhibits the reaction [IL32 protein results in increased expression of CD14 protein] CTD PMID:28711657 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Cd44 CD44 molecule (Indian blood group) multiple interactions
decreases expression		 ISO kaempferol inhibits the reaction [APOE affects the expression of CD44 mRNA]; kaempferol inhibits the reaction [APOE affects the expression of CD44 protein]
kaempferol results in decreased expression of CD44 mRNA; kaempferol results in decreased expression of CD44 protein
[Verapamil co-treated with kaempferol] results in decreased expression of CD44 mRNA; [Verapamil co-treated with kaempferol] results in decreased expression of CD44 protein; kaempferol inhibits the reaction [IL32 protein results in increased expression of CD44 protein]		 CTD PMID:22005275 PMID:28711657 PMID:35063459 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cdh5 cadherin 5 multiple interactions ISO kaempferol inhibits the reaction [Lipopolysaccharides results in decreased expression of CDH5 protein] CTD PMID:36243145 NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO kaempferol results in increased phosphorylation of and results in decreased activity of CDK1 protein CTD PMID:11322924 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions EXP [kaempferol co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [Oxygen deficiency results in increased expression of CDK2 protein]; kaempferol inhibits the reaction [Oxygen deficiency results in increased expression of CDK2 protein] CTD PMID:36940862 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions EXP [kaempferol co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [Oxygen deficiency results in increased expression of CDK4 protein]; kaempferol inhibits the reaction [Oxygen deficiency results in increased expression of CDK4 mRNA]; kaempferol inhibits the reaction [Oxygen deficiency results in increased expression of CDK4 protein] CTD PMID:36940862 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO kaempferol results in increased expression of CDKN1A mRNA; kaempferol results in increased expression of CDKN1A protein CTD PMID:19397994 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C decreases expression ISO kaempferol results in decreased expression of CDKN2C mRNA CTD PMID:18331776 NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278 		JBrowse link
G Cftr CF transmembrane conductance regulator affects localization ISO kaempferol affects the localization of CFTR protein mutant form CTD PMID:15191910 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Chek1 checkpoint kinase 1 increases phosphorylation ISO kaempferol results in increased phosphorylation of CHEK1 protein CTD PMID:24595819 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Chek2 checkpoint kinase 2 increases phosphorylation ISO kaempferol results in increased phosphorylation of CHEK2 protein CTD PMID:24595819 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex decreases phosphorylation
multiple interactions		 ISO kaempferol results in decreased phosphorylation of CHUK protein
kaempferol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein]		 CTD PMID:17184768 PMID:30769083 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Cldn2 claudin 2 multiple interactions EXP [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of CLDN2 protein CTD PMID:36049518 NCBI chr  X:103,459,870...103,473,794
Ensembl chr  X:103,459,780...103,474,838 		JBrowse link
G Col10a1 collagen type X alpha 1 chain increases expression ISO kaempferol results in increased expression of COL10A1 mRNA CTD PMID:23989061 NCBI chr20:38,183,103...38,189,488
Ensembl chr20:38,182,494...38,189,494 		JBrowse link
G Col2a1 collagen type II alpha 1 chain increases expression ISO kaempferol results in increased expression of COL2A1 mRNA CTD PMID:23989061 NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions EXP kaempferol inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA] CTD PMID:30372826 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Crp C-reactive protein decreases expression ISO kaempferol results in decreased expression of CRP mRNA; kaempferol results in decreased expression of CRP protein CTD PMID:17184768 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Cs citrate synthase increases activity ISO kaempferol results in increased activity of CS protein CTD PMID:31306686 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions
increases secretion		 ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; bisindolylmaleimide I inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Brefeldin A inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Colchicine inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Cytochalasin B inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Egtazic Acid inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Monensin inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Nocodazole inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; U 0126 inhibits the reaction [kaempferol results in increased secretion of CSF2 protein] CTD PMID:18346843 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP
ISO		 kaempferol promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CTNNB1 protein]]
kaempferol inhibits the reaction [Lipopolysaccharides results in decreased expression of CTNNB1 protein]		 CTD PMID:29999212 PMID:36243145 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions
affects localization		 ISO Caffeine inhibits the reaction [kaempferol affects the localization of CYCS protein] CTD PMID:19028473 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
increases activity
increases expression		 ISO [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; kaempferol inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; kaempferol inhibits the reaction [Smoke results in increased expression of CYP1A1 mRNA]; kaempferol inhibits the reaction [Smoke results in increased expression of CYP1A1 protein]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; kaempferol promotes the reaction [Quercetin results in increased expression of CYP1A1 mRNA]
kaempferol inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; kaempferol inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
kaempferol results in decreased activity of CYP1A1 protein
kaempferol results in increased activity of CYP1A1 protein
kaempferol results in increased expression of CYP1A1 mRNA		 CTD PMID:10359656 PMID:11454723 PMID:16271822 PMID:17012224 PMID:20846786 More... NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
decreases activity
multiple interactions		 ISO
EXP		 kaempferol results in increased expression of CYP1A2 mRNA
kaempferol results in decreased activity of CYP1A2 protein
kaempferol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]
kaempferol results in increased expression of and results in increased activity of CYP1A2 protein		 CTD PMID:18421621 PMID:19034627 PMID:20806393 PMID:21053930 PMID:21256954 More... NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases expression
multiple interactions
decreases activity		 ISO kaempferol results in decreased expression of CYP1B1 mRNA
kaempferol binds to and results in decreased activity of CYP1B1 protein; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1B1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1B1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]
kaempferol results in decreased activity of CYP1B1 protein		 CTD PMID:16271822 PMID:19794518 PMID:20846786 PMID:21053930 PMID:21482471 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases activity
multiple interactions		 ISO kaempferol results in decreased activity of CYP2C9 protein
kaempferol inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]		 CTD PMID:21053930 PMID:29753067 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO kaempferol inhibits the reaction [propacetamol results in increased expression of CYP2E1 protein] CTD PMID:29574133 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression
decreases activity		 ISO [kaempferol results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; kaempferol inhibits the reaction [CYP3A4 protein results in increased degradation of Hydrocortisone]
kaempferol results in increased expression of CYP3A4 mRNA
kaempferol results in decreased activity of CYP3A4 protein		 CTD PMID:15266218 PMID:16442130 PMID:21053930 PMID:25455453 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO kaempferol analog inhibits the reaction [Acetaminophen results in increased expression of CYP7A1 mRNA] CTD PMID:36150480 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Dhrs11 dehydrogenase/reductase 11 decreases activity ISO kaempferol results in decreased activity of DHRS11 protein CTD PMID:30926317 NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295 		JBrowse link
G Dio2 iodothyronine deiodinase 2 increases activity
increases expression
multiple interactions		 ISO kaempferol results in increased activity of DIO2 protein
kaempferol results in increased expression of DIO2 mRNA
kaempferol promotes the reaction [DIO2 protein results in increased activity of and results in increased abundance of Triiodothyronine]		 CTD PMID:17327447 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809 		JBrowse link
G Duox1 dual oxidase 1 multiple interactions ISO kaempferol inhibits the reaction [Paraquat results in increased expression of DUOX1 mRNA] CTD PMID:25177032 NCBI chr 3:109,260,526...109,295,588
Ensembl chr 3:109,262,397...109,295,563 		JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO kaempferol promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:20153296 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
affects binding
increases expression
increases activity		 ISO
EXP		 ESR1 protein inhibits the reaction [kaempferol results in increased expression of CCN5 mRNA]; ESR1 protein inhibits the reaction [kaempferol results in increased expression of PGR mRNA]; ESR1 protein inhibits the reaction [kaempferol results in increased expression of TFF1 mRNA]; Estradiol affects the reaction [kaempferol results in increased activity of ESR1 protein]; kaempferol binds to and results in increased activity of ESR1 protein; kaempferol inhibits the reaction [Estradiol binds to ESR1 protein]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 enhancer]]; kaempferol promotes the reaction [ESR1 protein binds to GREB1 enhancer]; kaempferol results in increased expression of and results in increased localization of ESR1 protein
kaempferol binds to ESR1 protein
kaempferol results in increased expression of ESR1 mRNA		 CTD PMID:9751507 PMID:14579009 PMID:14706564 PMID:15182386 PMID:16118406 More... NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
increases expression
affects binding
increases activity		 ISO
EXP		 Estradiol affects the reaction [kaempferol results in increased activity of ESR2 protein]; kaempferol binds to and results in increased activity of ESR2 protein; kaempferol inhibits the reaction [Estradiol binds to ESR2 protein]
kaempferol results in increased expression of ESR2 protein
ESR2 protein alternative form inhibits the reaction [kaempferol results in increased expression of ESR2 protein]
kaempferol binds to ESR2 protein		 CTD PMID:9751507 PMID:12224631 PMID:14706564 PMID:15182386 PMID:16118406 More... NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fbp1 fructose-bisphosphatase 1 decreases expression ISO kaempferol results in decreased expression of FBP1 mRNA CTD PMID:18331776 NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071 		JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions EXP [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of FGF2 protein CTD PMID:36049518 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fn1 fibronectin 1 increases expression ISO kaempferol results in increased expression of FN1 protein CTD PMID:26408079 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO kaempferol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]
kaempferol inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]		 CTD PMID:15322261 PMID:16434028 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta increases expression ISO kaempferol results in increased expression of GADD45B mRNA; kaempferol results in increased expression of GADD45B protein CTD PMID:18331776 NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions		 ISO kaempferol results in increased expression of GCLC mRNA
kaempferol affects the reaction [propacetamol affects the expression of GCLC protein]		 CTD PMID:11864778 PMID:29574133 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO kaempferol inhibits the reaction [Ethanol results in increased activity of GPT protein]; kaempferol inhibits the reaction [propacetamol results in increased activity of GPT protein] CTD PMID:29574133 PMID:31785310 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions
increases expression		 ISO Fulvestrant inhibits the reaction [kaempferol results in increased expression of GREB1 mRNA]; kaempferol promotes the reaction [ESR1 protein binds to GREB1 enhancer]; kaempferol promotes the reaction [NCOA3 protein binds to GREB1 enhancer] CTD PMID:20846786 PMID:33405908 PMID:35307500 NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP [kaempferol co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [Oxygen deficiency results in increased phosphorylation of GSK3B protein]; kaempferol inhibits the reaction [Chlorpyrifos results in increased expression of GSK3B mRNA]; kaempferol inhibits the reaction [Oxygen deficiency results in increased expression of GSK3B mRNA]; kaempferol inhibits the reaction [Oxygen deficiency results in increased phosphorylation of GSK3B protein] CTD PMID:30497708 PMID:36940862 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 increases expression ISO kaempferol results in increased expression of GSTA1 mRNA CTD PMID:21256954 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 multiple interactions ISO [Quercetin co-treated with kaempferol] results in increased expression of GSTM2 mRNA CTD PMID:25111660 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity ISO kaempferol results in decreased activity of GSTP1 protein CTD PMID:15041478 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G H2ax H2A.X variant histone increases phosphorylation
increases expression		 ISO kaempferol results in increased phosphorylation of H2AX protein
kaempferol results in increased expression of H2AX protein		 CTD PMID:19028473 PMID:24595819 PMID:35063459 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hbb hemoglobin subunit beta multiple interactions ISO kaempferol inhibits the reaction [HBB gene polymorphism results in increased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] CTD PMID:14691983 NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012 		JBrowse link
G Hgf hepatocyte growth factor multiple interactions ISO kaempferol inhibits the reaction [HGF protein results in increased phosphorylation of AKT1 protein]; kaempferol inhibits the reaction [HGF protein results in increased phosphorylation of MET protein] CTD PMID:19244381 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO
EXP		 kaempferol promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]
[kaempferol inhibits the reaction [Lipopolysaccharides co-treated with HIF1A protein]] which results in increased expression of MAPK14 protein; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with HIF1A protein]] which results in increased expression of VEGFA protein		 CTD PMID:20153296 PMID:36049518 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO
EXP		 Hemin promotes the reaction [kaempferol results in increased expression of HMOX1 protein]; HMOX1 protein promotes the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]; kaempferol affects the reaction [propacetamol affects the expression of HMOX1 protein]
[pterostilbene co-treated with kaempferol] results in increased expression of HMOX1 mRNA
kaempferol results in increased expression of HMOX1 mRNA; kaempferol results in increased expression of HMOX1 protein		 CTD PMID:14563492 PMID:16303981 PMID:19265714 PMID:25111660 PMID:29574133 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions EXP [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased phosphorylation of HSPB1 protein CTD PMID:36049518 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of ICAM1 protein]; kaempferol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; kaempferol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:15322261 PMID:16987811 PMID:18394220 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma multiple interactions ISO kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of ICAM1 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of PTGS2 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of SELE protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of VCAM1 protein] CTD PMID:18394220 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in decreased secretion of IL10 protein CTD PMID:36049518 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO kaempferol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of ICAM1 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of PTGS2 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of SELE protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of VCAM1 protein]; kaempferol inhibits the reaction [IL1B protein results in increased expression of MUC5AC mRNA]; kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of MAP3K7 protein]; kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]; kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; kaempferol inhibits the reaction [IL1B protein results in increased ubiquitination of IRAK1 protein]; kaempferol inhibits the reaction [IL1B protein results in increased ubiquitination of TRAF6 protein]; kaempferol inhibits the reaction [IL32 protein results in increased expression of IL1B mRNA]; kaempferol inhibits the reaction [IL32 protein results in increased secretion of IL1B protein]; kaempferol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein]		 CTD PMID:15985724 PMID:18394220 PMID:18946510 PMID:19367675 PMID:28711657 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO kaempferol inhibits the reaction [Calcimycin results in increased expression of IL4 mRNA] CTD PMID:12789233 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 multiple interactions ISO [Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in decreased expression of IL5 mRNA; kaempferol inhibits the reaction [Calcimycin results in increased expression of IL5 mRNA] CTD PMID:12789233 PMID:16797527 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP		 [Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in decreased expression of IL6 mRNA; kaempferol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 mRNA]
[kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of IL6 mRNA; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased secretion of IL6 protein; kaempferol inhibits the reaction [Oxaliplatin results in increased expression of IL6 mRNA]; kaempferol inhibits the reaction [Oxaliplatin results in increased expression of IL6 protein]
kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; kaempferol inhibits the reaction [propacetamol results in increased expression of IL6 protein]; kaempferol inhibits the reaction [TNF protein results in increased secretion of IL6 protein]		 CTD PMID:16434028 PMID:16797527 PMID:20438634 PMID:28711657 PMID:29574133 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 multiple interactions ISO kaempferol inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein]; kaempferol inhibits the reaction [INS1 protein results in increased activity of AKT1 protein]; kaempferol inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]; kaempferol promotes the reaction [INS1 protein results in increased uptake of Glucose] CTD PMID:18262572 PMID:18591783 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO kaempferol inhibits the reaction [IL1B protein results in increased ubiquitination of IRAK1 protein]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased ubiquitination of IRAK1 protein] CTD PMID:30769083 NCBI chr  X:151,768,621...151,778,521
Ensembl chr  X:151,768,777...151,778,521 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO kaempferol inhibits the reaction [IL32 protein results in increased expression of ITGAM mRNA]; kaempferol inhibits the reaction [IL32 protein results in increased expression of ITGAM protein] CTD PMID:28711657 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO kaempferol inhibits the reaction [Rotenone results in increased phosphorylation of JUN protein]; kaempferol inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; kaempferol inhibits the reaction [TNF protein results in increased expression of JUN mRNA] CTD PMID:15322261 PMID:20594614 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kdr kinase insert domain receptor multiple interactions EXP [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of KDR mRNA; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of KDR protein CTD PMID:36049518 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Kmt2a lysine methyltransferase 2A increases mutagenesis ISO kaempferol results in increased mutagenesis of KMT2A gene CTD PMID:17468513 NCBI chr 8:45,116,763...45,193,320
Ensembl chr 8:45,118,814...45,193,181 		JBrowse link
G Lamb2 laminin subunit beta 2 increases expression ISO kaempferol results in increased expression of LAMB2 protein CTD PMID:26408079 NCBI chr 8:109,178,367...109,190,552
Ensembl chr 8:109,178,409...109,190,549 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 multiple interactions ISO kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of MAP3K7 protein] CTD PMID:30769083 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity
increases phosphorylation
multiple interactions		 EXP
ISO		 kaempferol results in increased activity of MAPK1 protein
kaempferol results in increased phosphorylation of MAPK1 protein
3',4'-dihydroxyflavone analog inhibits the reaction [kaempferol results in increased phosphorylation of MAPK1 protein]; kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; kaempferol inhibits the reaction [Paraquat results in increased phosphorylation of MAPK1 protein]
kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK1 protein modified form]; kaempferol inhibits the reaction [propacetamol results in increased phosphorylation of MAPK1 protein]
kaempferol inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK1 protein]		 CTD PMID:15832817 PMID:16014620 PMID:18346843 PMID:19265714 PMID:19367675 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions EXP [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with HIF1A protein]] which results in increased expression of MAPK14 protein; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased phosphorylation of MAPK14 protein CTD PMID:36049518 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases activity
increases phosphorylation
multiple interactions		 EXP
ISO		 kaempferol results in increased activity of MAPK3 protein
kaempferol results in increased phosphorylation of MAPK3 protein
3',4'-dihydroxyflavone analog inhibits the reaction [kaempferol results in increased phosphorylation of MAPK3 protein]; kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]; kaempferol inhibits the reaction [Paraquat results in increased phosphorylation of MAPK3 protein]
kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK3 protein modified form]; kaempferol inhibits the reaction [propacetamol results in increased phosphorylation of MAPK3 protein]
kaempferol inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK3 protein]		 CTD PMID:15832817 PMID:16014620 PMID:18346843 PMID:19265714 PMID:19367675 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO kaempferol results in increased phosphorylation of MAPK8 protein CTD PMID:30499162 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO kaempferol results in increased phosphorylation of MAPK9 protein CTD PMID:30499162 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase multiple interactions ISO kaempferol inhibits the reaction [HGF protein results in increased phosphorylation of MET protein] CTD PMID:19244381 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [kaempferol results in decreased expression of MMP2 protein]; kaempferol results in decreased expression of and results in decreased activity of MMP2 protein CTD PMID:26408079 PMID:30499162 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO kaempferol results in decreased expression of MMP9 protein CTD PMID:34156145 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mt2A metallothionein 2A increases expression ISO kaempferol results in increased expression of MT2A mRNA CTD PMID:10656621 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO kaempferol inhibits the reaction [IL1B protein results in increased expression of MUC5AC mRNA]; kaempferol inhibits the reaction [Paraquat results in increased expression of MUC5AC mRNA] CTD PMID:19367675 PMID:25177032 NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475 		JBrowse link
G Mybl1 MYB proto-oncogene like 1 multiple interactions
increases expression		 ISO Fulvestrant inhibits the reaction [kaempferol results in increased expression of MYBL1 mRNA] CTD PMID:33405908 NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183 		JBrowse link
G Nanog Nanog homeobox increases expression
decreases expression
multiple interactions		 ISO kaempferol results in increased expression of NANOG protein
kaempferol results in decreased expression of NANOG mRNA; kaempferol results in decreased expression of NANOG protein
[Verapamil co-treated with kaempferol] results in decreased expression of NANOG mRNA; [Verapamil co-treated with kaempferol] results in decreased expression of NANOG protein		 CTD PMID:26683311 PMID:35063459 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116 		JBrowse link
G Ncoa3 nuclear receptor coactivator 3 multiple interactions ISO kaempferol promotes the reaction [NCOA3 protein binds to GREB1 enhancer] CTD PMID:20846786 NCBI chr 3:154,738,566...154,821,395
Ensembl chr 3:154,738,581...154,818,594 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression		 ISO
EXP		 [kaempferol co-treated with Quercetin] results in increased expression of NFE2L2 mRNA; kaempferol inhibits the reaction [Benzo(a)pyrene results in increased expression of NFE2L2 mRNA]
kaempferol inhibits the reaction [Chlorpyrifos results in decreased expression of NFE2L2 mRNA]
kaempferol affects the reaction [propacetamol affects the expression of NFE2L2 protein]
kaempferol results in increased expression of NFE2L2 mRNA		 CTD PMID:21256954 PMID:25111660 PMID:29574133 PMID:30497708 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha decreases phosphorylation
multiple interactions		 ISO kaempferol results in decreased phosphorylation of NFKBIA protein
kaempferol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]
kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]		 CTD PMID:17184768 PMID:20438634 PMID:30769083 PMID:36243145 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions		 ISO kaempferol results in decreased expression of NOS2 mRNA; kaempferol results in decreased expression of NOS2 protein
Hemin promotes the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; HMOX1 protein promotes the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]; kaempferol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; PPARG protein affects the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; tin protoporphyrin IX inhibits the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]
kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]		 CTD PMID:11343698 PMID:12512693 PMID:14563492 PMID:15832817 PMID:16934226 More... NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of NOS3 protein CTD PMID:36049518 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO kaempferol inhibits the reaction [Paraquat results in increased expression of NOX4 mRNA] CTD PMID:25177032 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [pterostilbene co-treated with kaempferol] results in increased expression of NQO1 protein; [Quercetin co-treated with kaempferol] results in increased expression of NQO1 protein CTD PMID:25111660 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO kaempferol analog inhibits the reaction [Acetaminophen results in decreased expression of NR1H4 mRNA] CTD PMID:36150480 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases expression
increases activity		 ISO [kaempferol results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; kaempferol binds to and results in increased activity of NR1I2 protein
kaempferol results in increased expression of NR1I2 mRNA		 CTD PMID:19034627 PMID:25455453 PMID:26238175 PMID:29933105 PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO kaempferol results in increased activity of NR1I3 protein CTD PMID:19034627 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Ocln occludin multiple interactions ISO
EXP		 kaempferol inhibits the reaction [Ethanol results in decreased expression of OCLN protein]
[kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in decreased expression of OCLN protein		 CTD PMID:31785310 PMID:36049518 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 EXP
ISO		 kaempferol inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]
3',4'-dihydroxyflavone analog inhibits the reaction [kaempferol results in increased cleavage of PARP1 protein]		 CTD PMID:16014620 PMID:22155320 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with kaempferol] inhibits the reaction [Oxygen deficiency results in increased expression of PCNA protein]; kaempferol inhibits the reaction [Oxygen deficiency results in increased expression of PCNA mRNA]; kaempferol inhibits the reaction [Oxygen deficiency results in increased expression of PCNA protein]; kaempferol promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein]] CTD PMID:29999212 PMID:36940862 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pgr progesterone receptor affects binding
increases expression
multiple interactions		 ISO kaempferol binds to PGR protein
kaempferol results in increased expression of PGR mRNA
ESR1 protein inhibits the reaction [kaempferol results in increased expression of PGR mRNA]; kaempferol inhibits the reaction [Progesterone binds to PGR protein]		 CTD PMID:14579009 PMID:23384675 PMID:35307500 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression
multiple interactions
increases expression		 ISO kaempferol results in decreased expression of POU5F1 mRNA; kaempferol results in decreased expression of POU5F1 protein
[Verapamil co-treated with kaempferol] results in decreased expression of POU5F1 mRNA; [Verapamil co-treated with kaempferol] results in decreased expression of POU5F1 protein
kaempferol results in increased expression of POU5F1 protein		 CTD PMID:22906706 PMID:26683311 PMID:35063459 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression		 ISO kaempferol binds to and results in increased activity of PPARG protein; kaempferol inhibits the reaction [Rosiglitazone binds to and results in increased activity of PPARG protein]; PPARG protein affects the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; PPARG protein affects the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]
kaempferol results in increased expression of PPARG mRNA; kaempferol results in increased expression of PPARG protein		 CTD PMID:11343698 PMID:18262572 PMID:25765892 PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO kaempferol results in increased expression of PPARGC1A mRNA CTD PMID:17327447 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Psca prostate stem cell antigen decreases expression ISO kaempferol results in decreased expression of PSCA mRNA CTD PMID:18331776 NCBI chr 7:106,598,203...106,603,114
Ensembl chr 7:106,595,284...106,609,746 		JBrowse link
G Ptges prostaglandin E synthase multiple interactions ISO kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGES mRNA] CTD PMID:21341175 NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression		 ISO kaempferol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; PPARG protein affects the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]
kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of PTGS2 protein]; kaempferol inhibits the reaction [TGFA protein results in increased expression of PTGS2 mRNA]
kaempferol results in decreased expression of PTGS2 mRNA; kaempferol results in decreased expression of PTGS2 protein		 CTD PMID:10783318 PMID:11343698 PMID:17184768 PMID:18394220 PMID:19352036 More... NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO kaempferol inhibits the reaction [Uric Acid promotes the reaction [PYCARD protein binds to PYCARD protein]] CTD PMID:29960001 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP		 kaempferol inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein]; kaempferol inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]; kaempferol inhibits the reaction [TNF protein results in increased localization of RELA protein]
[kaempferol affects the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of RELA mRNA; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased phosphorylation of RELA protein
kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RELA protein]		 CTD PMID:16434028 PMID:18274639 PMID:20438634 PMID:30769083 PMID:36049518 More... NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions ISO kaempferol inhibits the reaction [propacetamol results in increased expression of RIPK1 protein] CTD PMID:29574133 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
G Rpa3 replication protein A3 multiple interactions ISO [Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in increased expression of RPA3 mRNA CTD PMID:16797527 NCBI chr 4:36,304,649...36,307,755
Ensembl chr 4:36,304,651...36,307,709 		JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression ISO kaempferol results in increased expression of RUNX2 mRNA CTD PMID:23989061 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Sele selectin E multiple interactions ISO kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of SELE protein]; kaempferol inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:16987811 PMID:18394220 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Sfn stratifin increases expression ISO kaempferol results in increased expression of SFN mRNA; kaempferol results in increased expression of SFN protein CTD PMID:18331776 NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314 		JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions EXP
ISO		 [kaempferol results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate
kaempferol inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid]		 CTD PMID:17108059 PMID:25719685 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases activity
decreases expression
multiple interactions		 ISO kaempferol results in decreased activity of SLC2A1 protein
kaempferol results in decreased expression of SLC2A1 mRNA
kaempferol inhibits the reaction [SLC2A1 protein affects the transport of Glucose]; kaempferol inhibits the reaction [SLC2A1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]		 CTD PMID:14642735 PMID:25719685 PMID:36870413 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO kaempferol inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein] CTD PMID:18591783 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Slc5a8 solute carrier family 5 member 8 multiple interactions ISO kaempferol inhibits the reaction [Ethanol results in decreased expression of SLC5A8 protein] CTD PMID:31785310 NCBI chr 7:23,272,891...23,313,811
Ensembl chr 7:23,272,427...23,314,642 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO kaempferol inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein] CTD PMID:22394605 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Slco1c1 solute carrier organic anion transporter family, member 1c1 decreases activity
multiple interactions		 EXP kaempferol results in decreased activity of SLCO1B1 protein
[kaempferol results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [kaempferol results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Methotrexate		 CTD PMID:32259555 NCBI chr 4:174,466,621...174,513,290
Ensembl chr 4:174,466,631...174,513,289 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression		 ISO [pterostilbene co-treated with kaempferol] results in increased expression of SOD1 protein; [Quercetin co-treated with kaempferol] results in increased expression of SOD1 protein; kaempferol binds to and affects the folding of SOD1 protein mutant form
kaempferol results in increased expression of SOD1 protein		 CTD PMID:25111660 PMID:30260512 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
affects response to substance
increases expression		 ISO fulvestrant inhibits the reaction [kaempferol results in increased expression of SOD2 protein]
SOD2 protein affects the susceptibility to kaempferol		 CTD PMID:23526725 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sox2 SRY-box transcription factor 2 multiple interactions
decreases expression		 ISO [Verapamil co-treated with kaempferol] results in decreased expression of SOX2 mRNA
kaempferol results in decreased expression of SOX2 mRNA		 CTD PMID:35063459 NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338 		JBrowse link
G Sox9 SRY-box transcription factor 9 increases expression ISO kaempferol results in increased expression of SOX9 mRNA CTD PMID:23989061 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994 		JBrowse link
G Sphk1 sphingosine kinase 1 multiple interactions ISO kaempferol inhibits the reaction [Lipopolysaccharides affects the expression of SPHK1 protein]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of SPHK1 protein]
kaempferol inhibits the reaction [Lipopolysaccharides results in decreased expression of SPHK1 protein]		 CTD PMID:36243145 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO kaempferol inhibits the reaction [APOE affects the expression of SPP1 mRNA]; kaempferol inhibits the reaction [APOE affects the expression of SPP1 protein] CTD PMID:22005275 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO kaempferol inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of STAT1 protein alternative form] CTD PMID:18274639 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Stat2 signal transducer and activator of transcription 2 multiple interactions ISO [Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in decreased expression of STAT2 mRNA CTD PMID:16797527 NCBI chr 7:702,565...718,349
Ensembl chr 7:702,495...718,967 		JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO kaempferol results in increased expression of TFAM mRNA CTD PMID:17327447 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292 		JBrowse link
G Tff1 trefoil factor 1 increases expression
multiple interactions		 ISO kaempferol results in increased expression of TFF1 mRNA
ESR1 protein inhibits the reaction [kaempferol results in increased expression of TFF1 mRNA]		 CTD PMID:14706564 PMID:23384675 PMID:35307500 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO kaempferol inhibits the reaction [TGFA protein results in increased expression of PTGS2 mRNA] CTD PMID:10783318 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO
EXP		 kaempferol inhibits the reaction [Ethanol results in decreased expression of TJP1 protein]
[kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in decreased expression of TJP1 protein		 CTD PMID:31785310 PMID:36049518 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases activity		 ISO
EXP		 kaempferol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; kaempferol inhibits the reaction [propacetamol results in increased expression of TNF protein]; kaempferol inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; kaempferol inhibits the reaction [TNF protein results in increased localization of RELA protein]; kaempferol inhibits the reaction [TNF protein results in increased secretion of CCL2 protein]; kaempferol inhibits the reaction [TNF protein results in increased secretion of IL6 protein]
[kaempferol affects the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of RELA mRNA; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in decreased expression of OCLN protein; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in decreased expression of TJP1 protein; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in decreased secretion of IL10 protein; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of BAD protein; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of CASP9 protein; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of CLDN2 protein; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of FGF2 protein; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of IL6 mRNA; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of KDR mRNA; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of KDR protein; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of NOS3 protein; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of VEGFA mRNA; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of VEGFA protein; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased phosphorylation of HSPB1 protein; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased phosphorylation of MAPK14 protein; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased phosphorylation of RELA protein; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased secretion of IL6 protein; kaempferol inhibits the reaction [Oxaliplatin results in increased expression of TNF mRNA]; kaempferol inhibits the reaction [Oxaliplatin results in increased expression of TNF protein]
kaempferol results in decreased activity of TNF protein
kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of ICAM1 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of PTGS2 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of SELE protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of VCAM1 protein]; kaempferol inhibits the reaction [IL32 protein results in increased expression of TNF mRNA]; kaempferol inhibits the reaction [IL32 protein results in increased secretion of TNF protein]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; kaempferol inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; kaempferol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; kaempferol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; kaempferol inhibits the reaction [TNF protein results in increased expression of JUN mRNA]; kaempferol inhibits the reaction [TNF protein results in increased expression of SELE protein]		 CTD PMID:15322261 PMID:15985724 PMID:16434028 PMID:16934226 PMID:16987811 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 multiple interactions ISO kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA] CTD PMID:20438634 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A multiple interactions ISO kaempferol inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A mRNA] CTD PMID:16434028 NCBI chr13:21,928,370...21,986,719
Ensembl chr13:21,928,408...21,986,695 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO kaempferol inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA]; kaempferol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; kaempferol inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A mRNA] CTD PMID:16434028 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
affects response to substance
increases phosphorylation
increases expression		 ISO
EXP		 Caffeine inhibits the reaction [kaempferol results in increased phosphorylation of TP53 protein]; TP53 protein affects the reaction [kaempferol promotes the reaction [BBC3 protein binds to BCL2L1 protein]]
kaempferol inhibits the reaction [Doxorubicin promotes the reaction [TP53 protein binds to BAX promoter]]; kaempferol inhibits the reaction [Doxorubicin results in increased expression of TP53 mRNA]
TP53 protein affects the susceptibility to kaempferol
kaempferol results in increased expression of TP53 protein		 CTD PMID:19028473 PMID:22155320 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp53i3 tumor protein p53 inducible protein 3 increases expression ISO kaempferol results in increased expression of TP53I3 mRNA; kaempferol results in increased expression of TP53I3 protein CTD PMID:18331776 PMID:19397994 NCBI chr 6:27,818,327...27,825,753 JBrowse link
G Tp63 tumor protein p63 increases expression ISO kaempferol results in increased expression of TP63 protein CTD PMID:18331776 PMID:19397994 NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398 		JBrowse link
G Tp73 tumor protein p73 increases expression ISO kaempferol results in increased expression of TP73 protein CTD PMID:18331776 PMID:19397994 NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128 		JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO kaempferol inhibits the reaction [IL1B protein results in increased ubiquitination of TRAF6 protein] CTD PMID:30769083 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Tslp thymic stromal lymphopoietin multiple interactions ISO kaempferol inhibits the reaction [IL32 protein results in increased expression of TSLP mRNA]; kaempferol inhibits the reaction [IL32 protein results in increased secretion of TSLP protein]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased secretion of TSLP protein] CTD PMID:28711657 NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548 		JBrowse link
G Tubb3 tubulin, beta 3 class III decreases expression ISO kaempferol results in decreased expression of TUBB3 protein CTD PMID:26683311 NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243 		JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions EXP kaempferol inhibits the reaction [Dietary Fats results in decreased expression of UCP1 mRNA] CTD PMID:30372826 NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852 		JBrowse link
G Ucp3 uncoupling protein 3 increases expression ISO kaempferol results in increased expression of UCP3 mRNA CTD PMID:17327447 NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation
decreases activity
multiple interactions		 ISO UGT1A1 protein results in increased glucuronidation of kaempferol
kaempferol results in decreased activity of UGT1A1 protein
kaempferol inhibits the reaction [propacetamol results in decreased expression of UGT1A1 protein]		 CTD PMID:14557274 PMID:29574133 PMID:35063619 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation
decreases activity
affects glucuronidation		 ISO UGT1A3 protein results in increased glucuronidation of kaempferol
kaempferol results in decreased activity of UGT1A3 protein
UGT1A3 mutant form affects the glucuronidation of kaempferol		 CTD PMID:16738032 PMID:35063619 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation
decreases activity		 ISO UGT1A9 protein results in increased glucuronidation of kaempferol
kaempferol results in decreased activity of UGT1A9 protein		 CTD PMID:14557274 PMID:35063619 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 decreases activity ISO kaempferol results in decreased activity of UGT2B7 protein CTD PMID:35063619 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
G Utrn utrophin increases expression ISO kaempferol results in increased expression of UTRN mRNA CTD PMID:22028826 NCBI chr 1:6,720,854...7,224,313
Ensembl chr 1:6,722,594...7,224,313 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of VCAM1 protein] CTD PMID:18394220 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vdr vitamin D receptor increases activity ISO kaempferol results in increased activity of VDR protein CTD PMID:26366751 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO
EXP		 kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]
[kaempferol inhibits the reaction [Lipopolysaccharides co-treated with HIF1A protein]] which results in increased expression of VEGFA protein; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of VEGFA mRNA; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of VEGFA protein		 CTD PMID:20438634 PMID:36049518 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
afzelin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mitf melanocyte inducing transcription factor increases expression ISO afzelin results in increased expression of MITF mRNA; afzelin results in increased expression of MITF protein CTD PMID:27287415 NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145 		JBrowse link
G Tyr tyrosinase multiple interactions
increases expression		 ISO afzelin results in increased expression of and results in increased activity of TYR protein
afzelin results in increased expression of TYR mRNA		 CTD PMID:27287415 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
G Tyrp1 tyrosinase-related protein 1 increases expression ISO afzelin results in increased expression of TYRP1 mRNA; afzelin results in increased expression of TYRP1 protein CTD PMID:27287415 NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516 		JBrowse link
herbacetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fasn fatty acid synthase multiple interactions ISO herbacetin inhibits the reaction [Dietary Fats results in increased activity of FASN protein] CTD PMID:29653099 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions ISO herbacetin inhibits the reaction [Dietary Fats results in increased activity of G6PD protein] CTD PMID:29653099 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO herbacetin inhibits the reaction [Dietary Fats results in increased activity of GPT protein] CTD PMID:29653099 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO herbacetin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA] CTD PMID:29653099 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO herbacetin inhibits the reaction [Dietary Fats results in increased expression of SREBF2 mRNA] CTD PMID:29653099 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848 		JBrowse link
kaempferide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO kaempferide inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; kaempferide inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]] CTD PMID:34217736 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases expression ISO kaempferide results in decreased expression of SLC2A1 mRNA CTD PMID:21865046 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO kaempferide binds to and affects the folding of SOD1 protein mutant form CTD PMID:30260512 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO kaempferide results in increased expression of VEGFA mRNA CTD PMID:21865046 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
kaempferol 3-O-beta-D-galactoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pla2g2a phospholipase A2 group IIA affects activity ISO kaempferol-3-O-galactoside affects the activity of PLA2G2A protein CTD PMID:8190018 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014 		JBrowse link
kaempferol 3-O-beta-D-glucoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions ISO astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in decreased expression of APP protein] CTD PMID:35537655 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Cat catalase multiple interactions ISO astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in decreased expression of CAT protein] CTD PMID:35537655 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA] CTD PMID:22210036 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 mRNA] CTD PMID:22210036 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 multiple interactions ISO astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of HES1 protein] CTD PMID:35537655 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in decreased expression of IL10 protein] CTD PMID:35537655 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of IL1B protein]; astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] CTD PMID:22210036 PMID:35537655 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of IL6 protein]; astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:22210036 PMID:35537655 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO astragalin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein] CTD PMID:22210036 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:22210036 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Notch1 notch receptor 1 multiple interactions ISO astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of NOTCH1 protein] CTD PMID:35537655 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:22210036 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region multiple interactions ISO astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of RBPJ protein] CTD PMID:35537655 NCBI chr14:57,338,493...57,523,330
Ensembl chr14:57,338,507...57,523,353 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of and results in increased phosphorylation of RELA protein]; astragalin inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein] CTD PMID:22210036 PMID:35537655 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of TNF protein]; astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:22210036 PMID:35537655 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
robinin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 affects activity ISO robinin affects the activity of ABCC1 protein CTD PMID:15796199 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19908
    role 19883
      biological role 19881
        antimicrobial agent 18058
          antibacterial agent 15161
            kaempferol 193
              (+)-dihydrokaempferol + 0
              3,4'-dimethylkaempferol 0
              4',5,7-trihydroxy-3-methoxyflavone-7-O-beta-D-glucopyranoside 0
              4',5,7-trihydroxy-3-methoxyflavone-7-O-rutinoside 0
              563476_TEMP_6-hydroxykaempferol 0
              6''-O-acetylgenistin 0
              6''-malonylastragalin 0
              6-hydroxykaempferol 0
              7,4'-dimethylkaempferol 0
              8-lavandulylkaempferol 0
              afzelin 3
              cudranian 1 0
              herbacetin 5
              hermannioside B 0
              kaempferide + 4
              kaempferol 3,7-di-O-alpha-L-rhamnoside 0
              kaempferol 3-O-(5-O-acetyl-alpha-D-apiofuranosyl)-7-O-alpha-L-rhamnopyranoside 0
              kaempferol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] 0
              kaempferol 3-O-[alpha-L-rhamnopyranosyl(1->2)-beta-D-galactopyranosyl]-7-O-alpha-L-rhamnopyranoside 0
              kaempferol 3-O-alpha-L-arabinopyranosyl-7-O-alpha-L-rhamnopyranoside 0
              kaempferol 3-O-beta-D-allopyranoside 0
              kaempferol 3-O-beta-D-apiofuranosyl-7-O-alpha-L-rhamnopyranoside 0
              kaempferol 3-O-beta-D-galactopyranosyl-7-O-alpha-L-rhamnopyranoside 0
              kaempferol 3-O-beta-D-galactoside 1
              kaempferol 3-O-beta-D-glucosylgalactoside 0
              kaempferol 3-O-beta-D-xyloside 0
              kaempferol 3-O-gentiobioside-7-O-rhamnoside 0
              kaempferol 7-O-beta-D-galactopyranoside 0
              kaempferol O-glucoside + 15
              kaempferol O-glucuronide + 0
              multiflorin B 0
              rhamnocitrin 0
              robinin 1
              sexangularetin 0
              tribuloside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19908
    subatomic particle 19906
      composite particle 19906
        hadron 19906
          baryon 19906
            nucleon 19906
              atomic nucleus 19906
                atom 19906
                  main group element atom 19853
                    p-block element atom 19853
                      carbon group element atom 19799
                        carbon atom 19794
                          organic molecular entity 19794
                            organic molecule 19751
                              organic cyclic compound 19559
                                organic heterocyclic compound 18896
                                  oxacycle 17813
                                    benzopyran 11734
                                      1-benzopyran 11498
                                        flavonoid 6833
                                          anthoxanthin 4522
                                            flavones 4522
                                              hydroxyflavone 4508
                                                flavonols 4404
                                                  7-hydroxyflavonol 4381
                                                    kaempferol 193
                                                      (+)-dihydrokaempferol + 0
                                                      3,4'-dimethylkaempferol 0
                                                      4',5,7-trihydroxy-3-methoxyflavone-7-O-beta-D-glucopyranoside 0
                                                      4',5,7-trihydroxy-3-methoxyflavone-7-O-rutinoside 0
                                                      563476_TEMP_6-hydroxykaempferol 0
                                                      6''-O-acetylgenistin 0
                                                      6''-malonylastragalin 0
                                                      6-hydroxykaempferol 0
                                                      7,4'-dimethylkaempferol 0
                                                      8-lavandulylkaempferol 0
                                                      afzelin 3
                                                      cudranian 1 0
                                                      herbacetin 5
                                                      hermannioside B 0
                                                      kaempferide + 4
                                                      kaempferol 3,7-di-O-alpha-L-rhamnoside 0
                                                      kaempferol 3-O-(5-O-acetyl-alpha-D-apiofuranosyl)-7-O-alpha-L-rhamnopyranoside 0
                                                      kaempferol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] 0
                                                      kaempferol 3-O-[alpha-L-rhamnopyranosyl(1->2)-beta-D-galactopyranosyl]-7-O-alpha-L-rhamnopyranoside 0
                                                      kaempferol 3-O-alpha-L-arabinopyranosyl-7-O-alpha-L-rhamnopyranoside 0
                                                      kaempferol 3-O-beta-D-allopyranoside 0
                                                      kaempferol 3-O-beta-D-apiofuranosyl-7-O-alpha-L-rhamnopyranoside 0
                                                      kaempferol 3-O-beta-D-galactopyranosyl-7-O-alpha-L-rhamnopyranoside 0
                                                      kaempferol 3-O-beta-D-galactoside 1
                                                      kaempferol 3-O-beta-D-glucosylgalactoside 0
                                                      kaempferol 3-O-beta-D-xyloside 0
                                                      kaempferol 3-O-gentiobioside-7-O-rhamnoside 0
                                                      kaempferol 7-O-beta-D-galactopyranoside 0
                                                      kaempferol O-glucoside + 15
                                                      kaempferol O-glucuronide + 0
                                                      multiflorin B 0
                                                      rhamnocitrin 0
                                                      robinin 1
                                                      sexangularetin 0
                                                      tribuloside 0
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