|
G
|
Abcb1a
|
ATP binding cassette subfamily B member 1A
|
increases transport decreases expression increases activity multiple interactions
|
ISO
|
ABCB1 protein results in increased transport of kaempferol kaempferol results in decreased expression of ABCB1 mRNA; kaempferol results in decreased expression of ABCB1 protein kaempferol results in increased activity of ABCB1 protein [Verapamil co-treated with kaempferol] results in decreased expression of ABCB1 mRNA; [Verapamil co-treated with kaempferol] results in decreased expression of ABCB1 protein; kaempferol inhibits the reaction [[ABCB1 protein results in decreased susceptibility to Doxorubicin] promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA]]; kaempferol inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; kaempferol inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; kaempferol inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; Verapamil promotes the reaction [kaempferol results in increased activity of ABCB1 protein]
|
CTD |
PMID:15266218 PMID:15969930 PMID:20438634 PMID:34217736 PMID:35063459 |
|
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
|
|
G
|
Abcc1
|
ATP binding cassette subfamily C member 1
|
decreases activity increases activity multiple interactions affects activity
|
ISO
|
kaempferol results in decreased activity of ABCC1 protein kaempferol results in increased activity of ABCC1 protein kaempferol affects the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; kaempferol inhibits the reaction [ABCC1 protein results in increased uptake of Leukotriene C4] kaempferol affects the activity of ABCC1 protein
|
CTD |
PMID:11306701 PMID:15670588 PMID:15796199 |
|
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
|
|
G
|
Ache
|
acetylcholinesterase
|
multiple interactions
|
EXP
|
kaempferol inhibits the reaction [Chlorpyrifos results in decreased activity of ACHE protein]
|
CTD |
PMID:30497708 |
|
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
|
|
G
|
Acta2
|
actin alpha 2, smooth muscle
|
decreases expression multiple interactions
|
ISO
|
kaempferol results in decreased expression of ACTA2 protein [kaempferol co-treated with Luteolin] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; [kaempferol co-treated with Luteolin] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; dorsomorphin inhibits the reaction [[kaempferol co-treated with Luteolin] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]]; kaempferol inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
|
CTD |
PMID:26683311 PMID:37308028 |
|
NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554
|
|
G
|
Adipoq
|
adiponectin, C1Q and collagen domain containing
|
increases expression
|
ISO
|
kaempferol results in increased expression of ADIPOQ protein
|
CTD |
PMID:30445784 |
|
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
|
|
G
|
Afp
|
alpha-fetoprotein
|
affects binding decreases expression
|
EXP ISO
|
kaempferol binds to AFP protein kaempferol results in decreased expression of AFP protein
|
CTD |
PMID:23013281 PMID:25349334 PMID:26683311 |
|
NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
|
|
G
|
Ahr
|
aryl hydrocarbon receptor
|
affects binding multiple interactions increases activity
|
ISO
|
kaempferol binds to AHR protein kaempferol inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1B1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1B1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AHR protein] kaempferol results in increased activity of AHR protein kaempferol inhibits the reaction [beta-Naphthoflavone promotes the reaction [AHR protein binds to ARNT protein]]; kaempferol inhibits the reaction [beta-Naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [AHR protein binds to AIP protein]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of AHR protein]
|
CTD |
PMID:10359656 PMID:14644660 PMID:17012224 PMID:19034627 PMID:19794518 PMID:20450880 PMID:20846786 More...
|
|
NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
|
|
G
|
Aip
|
aryl-hydrocarbon receptor-interacting protein
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [AHR protein binds to AIP protein]]
|
CTD |
PMID:20450880 |
|
NCBI chr 1:201,408,002...201,419,220
Ensembl chr 1:201,407,288...201,419,122
|
|
G
|
Akt1
|
AKT serine/threonine kinase 1
|
multiple interactions decreases phosphorylation decreases expression
|
ISO EXP
|
kaempferol inhibits the reaction [HGF protein results in increased phosphorylation of AKT1 protein]; kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of AKT1 protein] kaempferol inhibits the reaction [INS1 protein results in increased activity of AKT1 protein] kaempferol results in decreased phosphorylation of AKT1 protein [kaempferol co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]; kaempferol inhibits the reaction [Oxygen deficiency results in increased expression of AKT1 mRNA]; kaempferol inhibits the reaction [Oxygen deficiency results in increased expression of AKT1 protein]; kaempferol inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein] kaempferol results in decreased expression of AKT1 mRNA
|
CTD |
PMID:18591783 PMID:19244381 PMID:20438634 PMID:36819991 PMID:36940862 PMID:37923178 More...
|
|
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
|
|
G
|
Alox12
|
arachidonate 12-lipoxygenase, 12S type
|
decreases activity multiple interactions
|
ISO
|
kaempferol results in decreased activity of ALOX12 protein kaempferol inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid]
|
CTD |
PMID:17027136 |
|
NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542
|
|
G
|
Alox5
|
arachidonate 5-lipoxygenase
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4]
|
CTD |
PMID:18096136 |
|
NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
|
|
G
|
Apoe
|
apolipoprotein E
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [APOE affects the expression of CD44 mRNA]; kaempferol inhibits the reaction [APOE affects the expression of CD44 protein]; kaempferol inhibits the reaction [APOE affects the expression of SPP1 mRNA]; kaempferol inhibits the reaction [APOE affects the expression of SPP1 protein]
|
CTD |
PMID:22005275 |
|
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
|
|
G
|
App
|
amyloid beta precursor protein
|
multiple interactions
|
EXP
|
kaempferol inhibits the reaction [APP protein binds to APP protein]
|
CTD |
PMID:17323972 |
|
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
|
|
G
|
Ar
|
androgen receptor
|
multiple interactions
|
ISO
|
kaempferol binds to and results in increased activity of AR protein; kaempferol inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein]
|
CTD |
PMID:29162470 PMID:33049310 |
|
NCBI chr X:67,135,317...67,304,476
Ensembl chr X:63,104,771...63,273,925
|
|
G
|
Arnt
|
aryl hydrocarbon receptor nuclear translocator
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [beta-Naphthoflavone promotes the reaction [AHR protein binds to ARNT protein]]; kaempferol inhibits the reaction [beta-Naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]] kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein]
|
CTD |
PMID:17012224 PMID:20450880 PMID:20846786 |
|
NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
|
|
G
|
Atm
|
ATM serine/threonine kinase
|
multiple interactions increases phosphorylation
|
ISO
|
Caffeine inhibits the reaction [kaempferol results in increased phosphorylation of ATM protein]
|
CTD |
PMID:19028473 |
|
NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
|
|
G
|
B3galt5
|
Beta-1,3-galactosyltransferase 5
|
decreases expression
|
ISO
|
kaempferol results in decreased expression of B3GALT5 protein
|
CTD |
PMID:22906706 |
|
NCBI chr11:35,584,273...35,630,922
Ensembl chr11:35,585,220...35,630,917
|
|
G
|
Bad
|
BCL2-associated agonist of cell death
|
multiple interactions
|
EXP
|
[kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of BAD protein
|
CTD |
PMID:36049518 |
|
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
|
|
G
|
Bax
|
BCL2 associated X, apoptosis regulator
|
increases expression multiple interactions
|
ISO EXP
|
kaempferol results in increased expression of BAX protein kaempferol inhibits the reaction [propacetamol results in increased expression of BAX protein] kaempferol inhibits the reaction [Doxorubicin promotes the reaction [TP53 protein binds to BAX promoter]]; kaempferol inhibits the reaction [Doxorubicin results in increased expression of BAX mRNA]; kaempferol inhibits the reaction [Oxygen deficiency results in decreased expression of BAX protein]
|
CTD |
PMID:19028473 PMID:22155320 PMID:29574133 PMID:36940862 |
|
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
|
|
G
|
Bbc3
|
Bcl-2 binding component 3
|
multiple interactions increases expression
|
ISO
|
Caffeine inhibits the reaction [kaempferol results in increased expression of BBC3 protein]; kaempferol promotes the reaction [BBC3 protein binds to BCL2L1 protein]; TP53 protein affects the reaction [kaempferol promotes the reaction [BBC3 protein binds to BCL2L1 protein]]
|
CTD |
PMID:19028473 |
|
NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:77,014,543...77,022,509
|
|
G
|
Bcl2
|
BCL2, apoptosis regulator
|
decreases expression multiple interactions
|
ISO EXP
|
kaempferol results in decreased expression of BCL2 protein kaempferol inhibits the reaction [Oxygen deficiency results in increased expression of BCL2 protein]
|
CTD |
PMID:19028473 PMID:36940862 |
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
|
|
G
|
Bcl2a1
|
BCL2-related protein A1
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2A1 mRNA]
|
CTD |
PMID:20438634 |
|
NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:89,716,914...89,724,998
|
|
G
|
Bcl2l1
|
Bcl2-like 1
|
multiple interactions
|
ISO
|
kaempferol promotes the reaction [BBC3 protein binds to BCL2L1 protein]; TP53 protein affects the reaction [kaempferol promotes the reaction [BBC3 protein binds to BCL2L1 protein]]
|
CTD |
PMID:19028473 |
|
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
|
|
G
|
Bmp2
|
bone morphogenetic protein 2
|
increases expression
|
ISO
|
kaempferol results in increased expression of BMP2 mRNA; kaempferol results in increased expression of BMP2 protein
|
CTD |
PMID:23989061 |
|
NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
|
|
G
|
Bmp4
|
bone morphogenetic protein 4
|
increases expression
|
ISO
|
kaempferol results in increased expression of BMP4 mRNA
|
CTD |
PMID:23989061 |
|
NCBI chr15:22,098,191...22,113,145
Ensembl chr15:19,618,542...19,623,306
|
|
G
|
Calcr
|
calcitonin receptor
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA]
|
CTD |
PMID:16434028 |
|
NCBI chr 4:31,661,270...31,736,392
Ensembl chr 4:31,661,273...31,736,392
|
|
G
|
Casp1
|
caspase 1
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [IL32 protein results in increased expression of and results in increased activity of CASP1 protein]
|
CTD |
PMID:28711657 |
|
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
|
|
G
|
Casp3
|
caspase 3
|
multiple interactions increases cleavage
|
EXP ISO
|
kaempferol inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]; kaempferol inhibits the reaction [Oxygen deficiency results in increased cleavage of CASP3 protein]; kaempferol promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of CASP3 protein]] kaempferol inhibits the reaction [propacetamol results in increased cleavage of CASP3 protein]; kaempferol inhibits the reaction [Rotenone results in increased cleavage of CASP3 protein] kaempferol results in increased cleavage of CASP3 protein 3',4'-dihydroxyflavone analog inhibits the reaction [kaempferol results in increased cleavage of CASP3 protein]; kaempferol inhibits the reaction [Rotenone results in increased cleavage of CASP3 protein]
|
CTD |
PMID:16014620 PMID:18331776 PMID:19028473 PMID:19397994 PMID:20594614 PMID:22155320 PMID:29574133 PMID:29999212 PMID:36940862 More...
|
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
|
|
G
|
Casp9
|
caspase 9
|
increases cleavage multiple interactions
|
ISO EXP
|
kaempferol results in increased cleavage of CASP9 protein [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of CASP9 protein kaempferol inhibits the reaction [Rotenone results in increased cleavage of CASP9 protein]
|
CTD |
PMID:18331776 PMID:20594614 PMID:36049518 |
|
Ensembl chr 5:154,109,046...154,126,626
|
|
G
|
Cat
|
catalase
|
multiple interactions
|
EXP ISO
|
kaempferol inhibits the reaction [Chlorpyrifos results in decreased activity of CAT protein]; kaempferol inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; kaempferol inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; kaempferol inhibits the reaction [Oxygen deficiency results in decreased expression of CAT protein] kaempferol inhibits the reaction [propacetamol results in decreased activity of CAT protein]
|
CTD |
PMID:22155320 PMID:29574133 PMID:30372826 PMID:30497708 PMID:37923178 |
|
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
|
|
G
|
Cckar
|
cholecystokinin A receptor
|
multiple interactions
|
EXP
|
kaempferol inhibits the reaction [8-sulfocholecystokinin octapeptide results in increased activity of CCKAR protein]
|
CTD |
PMID:24630973 |
|
NCBI chr14:57,292,397...57,300,747
Ensembl chr14:57,292,397...57,300,747
|
|
G
|
Ccl2
|
C-C motif chemokine ligand 2
|
multiple interactions
|
ISO EXP
|
kaempferol inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]; kaempferol inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; kaempferol inhibits the reaction [TNF protein results in increased secretion of CCL2 protein] kaempferol inhibits the reaction [Oxaliplatin results in increased expression of CCL2 mRNA] kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCL2 mRNA]
|
CTD |
PMID:16434028 PMID:20438634 PMID:31306686 PMID:35574720 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
|
|
G
|
Ccl5
|
C-C motif chemokine ligand 5
|
multiple interactions
|
ISO
|
[Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in decreased expression of CCL5 mRNA
|
CTD |
PMID:16797527 |
|
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
|
|
G
|
Ccn5
|
cellular communication network factor 5
|
increases expression multiple interactions
|
ISO
|
kaempferol results in increased expression of CCN5 mRNA ESR1 protein inhibits the reaction [kaempferol results in increased expression of CCN5 mRNA]
|
CTD |
PMID:23384675 |
|
NCBI chr 3:152,491,247...152,502,639
Ensembl chr 3:152,491,220...152,502,636
|
|
G
|
Ccna2
|
cyclin A2
|
multiple interactions
|
EXP
|
[Oxygen deficiency co-treated with kaempferol co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased expression of CCNA2 protein; [Oxygen deficiency co-treated with kaempferol] results in increased expression of CCNA2 protein; kaempferol inhibits the reaction [Oxygen deficiency results in increased expression of CCNA2 protein]
|
CTD |
PMID:36940862 |
|
NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577
|
|
G
|
Ccnb1
|
cyclin B1
|
decreases expression
|
ISO
|
kaempferol results in decreased expression of CCNB1 mRNA; kaempferol results in decreased expression of CCNB1 protein
|
CTD |
PMID:18331776 PMID:19397994 |
|
NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172
|
|
G
|
Ccnd1
|
cyclin D1
|
multiple interactions
|
ISO EXP
|
kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCND1 mRNA] [kaempferol co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [Oxygen deficiency results in increased expression of CCND1 protein]; kaempferol inhibits the reaction [Oxygen deficiency results in increased expression of CCND1 mRNA]; kaempferol inhibits the reaction [Oxygen deficiency results in increased expression of CCND1 protein]
|
CTD |
PMID:20438634 PMID:36940862 |
|
NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
|
|
G
|
Cd14
|
CD14 molecule
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [IL32 protein results in increased expression of CD14 mRNA]; kaempferol inhibits the reaction [IL32 protein results in increased expression of CD14 protein]
|
CTD |
PMID:28711657 |
|
NCBI chr18:28,609,558...28,611,409
Ensembl chr18:28,335,340...28,337,261
|
|
G
|
Cd44
|
CD44 molecule
|
multiple interactions decreases expression
|
ISO
|
kaempferol inhibits the reaction [APOE affects the expression of CD44 mRNA]; kaempferol inhibits the reaction [APOE affects the expression of CD44 protein] kaempferol results in decreased expression of CD44 mRNA; kaempferol results in decreased expression of CD44 protein [Verapamil co-treated with kaempferol] results in decreased expression of CD44 mRNA; [Verapamil co-treated with kaempferol] results in decreased expression of CD44 protein; kaempferol inhibits the reaction [IL32 protein results in increased expression of CD44 protein]
|
CTD |
PMID:22005275 PMID:28711657 PMID:35063459 |
|
NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:89,157,058...89,244,620
|
|
G
|
Cdh5
|
cadherin 5
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of CDH5 protein]; kaempferol inhibits the reaction [Lipopolysaccharides results in decreased expression of CDH5 protein]
|
CTD |
PMID:36243145 PMID:38823539 |
|
NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368
|
|
G
|
Cdk1
|
cyclin-dependent kinase 1
|
multiple interactions
|
ISO
|
kaempferol results in increased phosphorylation of and results in decreased activity of CDK1 protein
|
CTD |
PMID:11322924 |
|
NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408
|
|
G
|
Cdk2
|
cyclin dependent kinase 2
|
multiple interactions
|
EXP
|
[kaempferol co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [Oxygen deficiency results in increased expression of CDK2 protein]; kaempferol inhibits the reaction [Oxygen deficiency results in increased expression of CDK2 protein]
|
CTD |
PMID:36940862 |
|
NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403
|
|
G
|
Cdk4
|
cyclin-dependent kinase 4
|
multiple interactions
|
EXP
|
[kaempferol co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [Oxygen deficiency results in increased expression of CDK4 protein]; kaempferol inhibits the reaction [Oxygen deficiency results in increased expression of CDK4 mRNA]; kaempferol inhibits the reaction [Oxygen deficiency results in increased expression of CDK4 protein]
|
CTD |
PMID:36940862 |
|
NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403
|
|
G
|
Cdkn1a
|
cyclin-dependent kinase inhibitor 1A
|
increases expression
|
ISO
|
kaempferol results in increased expression of CDKN1A mRNA; kaempferol results in increased expression of CDKN1A protein
|
CTD |
PMID:19397994 |
|
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
|
|
G
|
Cdkn2c
|
cyclin-dependent kinase inhibitor 2C
|
decreases expression
|
ISO
|
kaempferol results in decreased expression of CDKN2C mRNA
|
CTD |
PMID:18331776 |
|
NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278
|
|
G
|
Cftr
|
CF transmembrane conductance regulator
|
affects localization
|
ISO
|
kaempferol affects the localization of CFTR protein mutant form
|
CTD |
PMID:15191910 |
|
NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
|
|
G
|
Chek1
|
checkpoint kinase 1
|
increases phosphorylation
|
ISO
|
kaempferol results in increased phosphorylation of CHEK1 protein
|
CTD |
PMID:24595819 |
|
NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
|
|
G
|
Chek2
|
checkpoint kinase 2
|
increases phosphorylation
|
ISO
|
kaempferol results in increased phosphorylation of CHEK2 protein
|
CTD |
PMID:24595819 |
|
NCBI chr12:51,448,838...51,481,159
Ensembl chr12:45,788,827...45,821,286
|
|
G
|
Chuk
|
component of inhibitor of nuclear factor kappa B kinase complex
|
decreases phosphorylation multiple interactions
|
ISO
|
kaempferol results in decreased phosphorylation of CHUK protein kaempferol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein]
|
CTD |
PMID:17184768 PMID:30769083 |
|
NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
|
|
G
|
Cldn2
|
claudin 2
|
multiple interactions
|
EXP
|
[kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of CLDN2 protein
|
CTD |
PMID:36049518 |
|
NCBI chr X:103,459,870...103,473,794
Ensembl chr X:103,459,780...103,474,838
|
|
G
|
Col10a1
|
collagen type X alpha 1 chain
|
increases expression
|
ISO
|
kaempferol results in increased expression of COL10A1 mRNA
|
CTD |
PMID:23989061 |
|
NCBI chr20:38,183,103...38,189,488
Ensembl chr20:38,182,494...38,189,494
|
|
G
|
Col2a1
|
collagen type II alpha 1 chain
|
increases expression
|
ISO
|
kaempferol results in increased expression of COL2A1 mRNA
|
CTD |
PMID:23989061 |
|
NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546
|
|
G
|
Cpt1a
|
carnitine palmitoyltransferase 1A
|
multiple interactions
|
EXP
|
kaempferol inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA]
|
CTD |
PMID:30372826 |
|
NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055
|
|
G
|
Crp
|
C-reactive protein
|
decreases expression
|
ISO
|
kaempferol results in decreased expression of CRP mRNA; kaempferol results in decreased expression of CRP protein
|
CTD |
PMID:17184768 |
|
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
|
|
G
|
Cs
|
citrate synthase
|
increases activity
|
ISO
|
kaempferol results in increased activity of CS protein
|
CTD |
PMID:31306686 |
|
NCBI chr 7:1,348,389...1,374,624
Ensembl chr 7:758,345...791,421
|
|
G
|
Csf2
|
colony stimulating factor 2
|
multiple interactions increases secretion
|
ISO
|
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; bisindolylmaleimide I inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Brefeldin A inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Colchicine inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Cytochalasin B inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Egtazic Acid inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Monensin inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Nocodazole inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; U 0126 inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]
|
CTD |
PMID:18346843 |
|
NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
|
|
G
|
Ctnnb1
|
catenin beta 1
|
multiple interactions
|
EXP ISO
|
kaempferol promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CTNNB1 protein]] kaempferol inhibits the reaction [Lipopolysaccharides results in decreased expression of CTNNB1 protein]
|
CTD |
PMID:29999212 PMID:36243145 |
|
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
|
|
G
|
Cycs
|
cytochrome c, somatic
|
multiple interactions affects localization
|
ISO
|
Caffeine inhibits the reaction [kaempferol affects the localization of CYCS protein]
|
CTD |
PMID:19028473 |
|
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
|
|
G
|
Cyp1a1
|
cytochrome P450, family 1, subfamily a, polypeptide 1
|
multiple interactions decreases activity increases activity increases expression
|
ISO
|
[Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; kaempferol inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; kaempferol inhibits the reaction [Smoke results in increased expression of CYP1A1 mRNA]; kaempferol inhibits the reaction [Smoke results in increased expression of CYP1A1 protein]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; kaempferol promotes the reaction [Quercetin results in increased expression of CYP1A1 mRNA] kaempferol inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; kaempferol inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA] kaempferol results in decreased activity of CYP1A1 protein kaempferol results in increased activity of CYP1A1 protein kaempferol results in increased expression of CYP1A1 mRNA
|
CTD |
PMID:10359656 PMID:11454723 PMID:16271822 PMID:17012224 PMID:20846786 PMID:20930378 PMID:21053930 PMID:21256954 PMID:21329749 PMID:21482471 PMID:29584932 More...
|
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
|
|
G
|
Cyp1a2
|
cytochrome P450, family 1, subfamily a, polypeptide 2
|
increases expression decreases activity multiple interactions
|
ISO EXP
|
kaempferol results in increased expression of CYP1A2 mRNA kaempferol results in decreased activity of CYP1A2 protein kaempferol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA] kaempferol results in increased expression of and results in increased activity of CYP1A2 protein
|
CTD |
PMID:18421621 PMID:19034627 PMID:20806393 PMID:21053930 PMID:21256954 PMID:29753067 More...
|
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
|
|
G
|
Cyp1b1
|
cytochrome P450, family 1, subfamily b, polypeptide 1
|
decreases expression multiple interactions decreases activity
|
ISO
|
kaempferol results in decreased expression of CYP1B1 mRNA kaempferol binds to and results in decreased activity of CYP1B1 protein; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1B1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1B1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA] kaempferol results in decreased activity of CYP1B1 protein
|
CTD |
PMID:16271822 PMID:19794518 PMID:20846786 PMID:21053930 PMID:21482471 |
|
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
|
|
G
|
Cyp2e1
|
cytochrome P450, family 2, subfamily e, polypeptide 1
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [propacetamol results in increased expression of CYP2E1 protein]
|
CTD |
PMID:29574133 |
|
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
|
|
G
|
Cyp3a2
|
cytochrome P450, family 3, subfamily a, polypeptide 2
|
multiple interactions increases expression decreases activity
|
ISO
|
[kaempferol results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; kaempferol inhibits the reaction [CYP3A4 protein results in increased degradation of Hydrocortisone] kaempferol results in increased expression of CYP3A4 mRNA kaempferol results in decreased activity of CYP3A4 protein
|
CTD |
PMID:15266218 PMID:16442130 PMID:21053930 PMID:25455453 |
|
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
|
|
G
|
Cyp7a1
|
cytochrome P450 family 7 subfamily A member 1
|
multiple interactions
|
ISO
|
kaempferol analog inhibits the reaction [Acetaminophen results in increased expression of CYP7A1 mRNA]
|
CTD |
PMID:36150480 |
|
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
|
|
G
|
Dhrs11
|
dehydrogenase/reductase 11
|
decreases activity
|
ISO
|
kaempferol results in decreased activity of DHRS11 protein
|
CTD |
PMID:30926317 |
|
NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295
|
|
G
|
Dio2
|
iodothyronine deiodinase 2
|
increases activity increases expression multiple interactions
|
ISO
|
kaempferol results in increased activity of DIO2 protein kaempferol results in increased expression of DIO2 mRNA kaempferol promotes the reaction [DIO2 protein results in increased activity of and results in increased abundance of Triiodothyronine]
|
CTD |
PMID:17327447 |
|
NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
|
|
G
|
Duox1
|
dual oxidase 1
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [Paraquat results in increased expression of DUOX1 mRNA]
|
CTD |
PMID:25177032 |
|
NCBI chr 3:109,260,526...109,295,588
Ensembl chr 3:109,262,397...109,295,563
|
|
G
|
Ep300
|
E1A binding protein p300
|
multiple interactions
|
ISO
|
kaempferol promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]
|
CTD |
PMID:20153296 |
|
NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:113,106,247...113,136,088 Ensembl chr 7:113,106,247...113,136,088
|
|
G
|
Esr1
|
estrogen receptor 1
|
multiple interactions affects binding increases expression increases activity
|
ISO EXP
|
ESR1 protein inhibits the reaction [kaempferol results in increased expression of CCN5 mRNA]; ESR1 protein inhibits the reaction [kaempferol results in increased expression of PGR mRNA]; ESR1 protein inhibits the reaction [kaempferol results in increased expression of TFF1 mRNA]; Estradiol affects the reaction [kaempferol results in increased activity of ESR1 protein]; kaempferol binds to and results in increased activity of ESR1 protein; kaempferol inhibits the reaction [Estradiol binds to ESR1 protein]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 enhancer]]; kaempferol promotes the reaction [ESR1 protein binds to GREB1 enhancer]; kaempferol results in increased expression of and results in increased localization of ESR1 protein kaempferol binds to ESR1 protein kaempferol results in increased expression of ESR1 mRNA
|
CTD |
PMID:9751507 PMID:14579009 PMID:14706564 PMID:15182386 PMID:16118406 PMID:19913605 PMID:20846786 PMID:23384675 PMID:29162470 PMID:33049310 More...
|
|
NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002
|
|
G
|
Esr2
|
estrogen receptor 2
|
multiple interactions increases expression affects binding increases activity
|
ISO EXP
|
Estradiol affects the reaction [kaempferol results in increased activity of ESR2 protein]; kaempferol binds to and results in increased activity of ESR2 protein; kaempferol inhibits the reaction [Estradiol binds to ESR2 protein] kaempferol results in increased expression of ESR2 protein ESR2 protein alternative form inhibits the reaction [kaempferol results in increased expression of ESR2 protein] kaempferol binds to ESR2 protein
|
CTD |
PMID:9751507 PMID:12224631 PMID:14706564 PMID:15182386 PMID:16118406 PMID:18937077 PMID:19913605 PMID:27634370 PMID:33049310 More...
|
|
NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919
|
|
G
|
Fbp1
|
fructose-bisphosphatase 1
|
decreases expression
|
ISO
|
kaempferol results in decreased expression of FBP1 mRNA
|
CTD |
PMID:18331776 |
|
NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071
|
|
G
|
Fgf2
|
fibroblast growth factor 2
|
multiple interactions
|
EXP
|
[kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of FGF2 protein
|
CTD |
PMID:36049518 |
|
NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:120,236,328...120,291,221
|
|
G
|
Fn1
|
fibronectin 1
|
increases expression
|
ISO
|
kaempferol results in increased expression of FN1 protein
|
CTD |
PMID:26408079 |
|
NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:73,196,044...73,264,678
|
|
G
|
Fos
|
Fos proto-oncogene, AP-1 transcription factor subunit
|
multiple interactions
|
ISO EXP
|
kaempferol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA] kaempferol inhibits the reaction [PDGFB protein results in increased expression of FOS mRNA] kaempferol inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]
|
CTD |
PMID:15322261 PMID:16041643 PMID:16434028 |
|
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
|
|
G
|
Gadd45b
|
growth arrest and DNA-damage-inducible, beta
|
increases expression
|
ISO
|
kaempferol results in increased expression of GADD45B mRNA; kaempferol results in increased expression of GADD45B protein
|
CTD |
PMID:18331776 |
|
NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
|
|
G
|
Gclc
|
glutamate-cysteine ligase, catalytic subunit
|
increases expression multiple interactions
|
ISO
|
kaempferol results in increased expression of GCLC mRNA kaempferol affects the reaction [propacetamol affects the expression of GCLC protein]
|
CTD |
PMID:11864778 PMID:29574133 |
|
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
|
|
G
|
Gpt
|
glutamic--pyruvic transaminase
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [Ethanol results in increased activity of GPT protein]; kaempferol inhibits the reaction [propacetamol results in increased activity of GPT protein]
|
CTD |
PMID:29574133 PMID:31785310 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
|
|
G
|
Greb1
|
growth regulating estrogen receptor binding 1
|
multiple interactions increases expression
|
ISO
|
Fulvestrant inhibits the reaction [kaempferol results in increased expression of GREB1 mRNA]; kaempferol promotes the reaction [ESR1 protein binds to GREB1 enhancer]; kaempferol promotes the reaction [NCOA3 protein binds to GREB1 enhancer]
|
CTD |
PMID:20846786 PMID:33405908 PMID:35307500 |
|
NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633
|
|
G
|
Gsk3b
|
glycogen synthase kinase 3 beta
|
multiple interactions
|
EXP
|
[kaempferol co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [Oxygen deficiency results in increased phosphorylation of GSK3B protein]; kaempferol inhibits the reaction [Chlorpyrifos results in increased expression of GSK3B mRNA]; kaempferol inhibits the reaction [Oxygen deficiency results in increased expression of GSK3B mRNA]; kaempferol inhibits the reaction [Oxygen deficiency results in increased phosphorylation of GSK3B protein]
|
CTD |
PMID:30497708 PMID:36940862 |
|
NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646
|
|
G
|
Gsta1
|
glutathione S-transferase alpha 1
|
increases expression
|
ISO
|
kaempferol results in increased expression of GSTA1 mRNA
|
CTD |
PMID:21256954 |
|
NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
|
|
G
|
Gstm2
|
glutathione S-transferase mu 2
|
multiple interactions
|
ISO
|
[Quercetin co-treated with kaempferol] results in increased expression of GSTM2 mRNA
|
CTD |
PMID:25111660 |
|
NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
|
|
G
|
Gstp1
|
glutathione S-transferase pi 1
|
decreases activity
|
ISO
|
kaempferol results in decreased activity of GSTP1 protein
|
CTD |
PMID:15041478 |
|
NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226
|
|
G
|
H2ax
|
H2A.X variant histone
|
increases phosphorylation increases expression
|
ISO
|
kaempferol results in increased phosphorylation of H2AX protein kaempferol results in increased expression of H2AX protein
|
CTD |
PMID:19028473 PMID:24595819 PMID:35063459 |
|
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 Ensembl chr 4:44,671,786...44,673,239
|
|
G
|
Hbb
|
hemoglobin subunit beta
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [HBB gene polymorphism results in increased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]
|
CTD |
PMID:14691983 |
|
NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012
|
|
G
|
Hgf
|
hepatocyte growth factor
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [HGF protein results in increased phosphorylation of AKT1 protein]; kaempferol inhibits the reaction [HGF protein results in increased phosphorylation of MET protein]
|
CTD |
PMID:19244381 |
|
NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
|
|
G
|
Hif1a
|
hypoxia inducible factor 1 subunit alpha
|
multiple interactions
|
ISO EXP
|
kaempferol promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with HIF1A protein]] which results in increased expression of MAPK14 protein; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with HIF1A protein]] which results in increased expression of VEGFA protein
|
CTD |
PMID:20153296 PMID:36049518 |
|
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
|
|
G
|
Hmox1
|
heme oxygenase 1
|
multiple interactions increases expression
|
ISO EXP
|
Hemin promotes the reaction [kaempferol results in increased expression of HMOX1 protein]; HMOX1 protein promotes the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]; kaempferol affects the reaction [propacetamol affects the expression of HMOX1 protein] [pterostilbene co-treated with kaempferol] results in increased expression of HMOX1 mRNA kaempferol results in increased expression of HMOX1 mRNA; kaempferol results in increased expression of HMOX1 protein
|
CTD |
PMID:14563492 PMID:16303981 PMID:19265714 PMID:25111660 PMID:29574133 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
|
|
G
|
Hspb1
|
heat shock protein family B (small) member 1
|
multiple interactions
|
EXP
|
[kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased phosphorylation of HSPB1 protein
|
CTD |
PMID:36049518 |
|
NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
|
|
G
|
Icam1
|
intercellular adhesion molecule 1
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of ICAM1 protein]; kaempferol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; kaempferol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
|
CTD |
PMID:15322261 PMID:16987811 PMID:18394220 |
|
NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438
|
|
G
|
Ifng
|
interferon gamma
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of ICAM1 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of PTGS2 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of SELE protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of VCAM1 protein]
|
CTD |
PMID:18394220 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
|
|
G
|
Il10
|
interleukin 10
|
multiple interactions
|
EXP
|
[kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in decreased secretion of IL10 protein
|
CTD |
PMID:36049518 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
|
|
G
|
Il1b
|
interleukin 1 beta
|
multiple interactions decreases expression
|
ISO
|
kaempferol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] kaempferol results in decreased expression of IL1B protein kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of ICAM1 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of PTGS2 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of SELE protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of VCAM1 protein]; kaempferol inhibits the reaction [IL1B protein results in increased expression of MUC5AC mRNA]; kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of MAP3K7 protein]; kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]; kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; kaempferol inhibits the reaction [IL1B protein results in increased ubiquitination of IRAK1 protein]; kaempferol inhibits the reaction [IL1B protein results in increased ubiquitination of TRAF6 protein]; kaempferol inhibits the reaction [IL32 protein results in increased expression of IL1B mRNA]; kaempferol inhibits the reaction [IL32 protein results in increased secretion of IL1B protein]; kaempferol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein]
|
CTD |
PMID:15985724 PMID:18394220 PMID:18946510 PMID:19367675 PMID:28711657 PMID:30769083 PMID:37115092 More...
|
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G
|
Il33
|
interleukin 33
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [Diethylhexyl Phthalate results in increased secretion of IL33 protein] kaempferol inhibits the reaction [Diethylhexyl Phthalate results in increased expression of IL33 mRNA]; kaempferol inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of IL33 mRNA]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IL33 mRNA]
|
CTD |
PMID:37545493 |
|
NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
|
|
G
|
Il4
|
interleukin 4
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [Calcimycin results in increased expression of IL4 mRNA]
|
CTD |
PMID:12789233 |
|
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
|
|
G
|
Il5
|
interleukin 5
|
multiple interactions
|
ISO
|
[Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in decreased expression of IL5 mRNA; kaempferol inhibits the reaction [Calcimycin results in increased expression of IL5 mRNA]
|
CTD |
PMID:12789233 PMID:16797527 |
|
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
|
|
G
|
Il6
|
interleukin 6
|
multiple interactions decreases expression
|
ISO EXP
|
[Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in decreased expression of IL6 mRNA; kaempferol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 mRNA] kaempferol results in decreased expression of IL6 protein [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of IL6 mRNA; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased secretion of IL6 protein; kaempferol inhibits the reaction [Oxaliplatin results in increased expression of IL6 mRNA]; kaempferol inhibits the reaction [Oxaliplatin results in increased expression of IL6 protein]; kaempferol inhibits the reaction [Oxygen deficiency results in increased expression of IL6 protein] kaempferol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; kaempferol inhibits the reaction [propacetamol results in increased expression of IL6 protein]; kaempferol inhibits the reaction [TNF protein results in increased secretion of IL6 protein]
|
CTD |
PMID:16434028 PMID:16797527 PMID:20438634 PMID:28711657 PMID:29574133 PMID:30769083 PMID:35574720 PMID:36049518 PMID:36243145 PMID:37115092 PMID:37923178 PMID:38823539 More...
|
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G
|
Ins1
|
insulin 1
|
multiple interactions increases secretion
|
ISO EXP
|
kaempferol inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein]; kaempferol inhibits the reaction [INS1 protein results in increased activity of AKT1 protein]; kaempferol inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]; kaempferol promotes the reaction [INS1 protein results in increased uptake of Glucose] kaempferol results in increased secretion of INS1 protein
|
CTD |
PMID:18262572 PMID:18591783 PMID:30445784 |
|
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
|
|
G
|
Irak1
|
interleukin-1 receptor-associated kinase 1
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [IL1B protein results in increased ubiquitination of IRAK1 protein]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased ubiquitination of IRAK1 protein]
|
CTD |
PMID:30769083 |
|
NCBI chr X:151,768,621...151,778,521
Ensembl chr X:151,768,777...151,778,521
|
|
G
|
Itgam
|
integrin subunit alpha M
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [IL32 protein results in increased expression of ITGAM mRNA]; kaempferol inhibits the reaction [IL32 protein results in increased expression of ITGAM protein]
|
CTD |
PMID:28711657 |
|
NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
|
|
G
|
Jun
|
Jun proto-oncogene, AP-1 transcription factor subunit
|
multiple interactions decreases expression
|
ISO
|
kaempferol inhibits the reaction [Rotenone results in increased phosphorylation of JUN protein]; kaempferol inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; kaempferol inhibits the reaction [TNF protein results in increased expression of JUN mRNA] kaempferol results in decreased expression of JUN protein
|
CTD |
PMID:15322261 PMID:20594614 PMID:37115092 |
|
NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656
|
|
G
|
Kdr
|
kinase insert domain receptor
|
multiple interactions
|
EXP
|
[kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of KDR mRNA; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of KDR protein
|
CTD |
PMID:36049518 |
|
NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
|
|
G
|
Kmt2a
|
lysine methyltransferase 2A
|
increases mutagenesis
|
ISO
|
kaempferol results in increased mutagenesis of KMT2A gene
|
CTD |
PMID:17468513 |
|
NCBI chr 8:45,116,763...45,193,320
Ensembl chr 8:45,118,814...45,193,181
|
|
G
|
Lamb2
|
laminin subunit beta 2
|
increases expression
|
ISO
|
kaempferol results in increased expression of LAMB2 protein
|
CTD |
PMID:26408079 |
|
NCBI chr 8:109,178,367...109,190,552
Ensembl chr 8:109,178,409...109,190,549
|
|
G
|
Lep
|
leptin
|
decreases expression
|
ISO
|
kaempferol results in decreased expression of LEP protein
|
CTD |
PMID:30445784 |
|
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
|
|
G
|
Map3k7
|
mitogen activated protein kinase kinase kinase 7
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of MAP3K7 protein]
|
CTD |
PMID:30769083 |
|
NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
|
|
G
|
Mapk1
|
mitogen activated protein kinase 1
|
increases activity increases phosphorylation multiple interactions
|
EXP ISO
|
kaempferol results in increased activity of MAPK1 protein kaempferol results in increased phosphorylation of MAPK1 protein 3',4'-dihydroxyflavone analog inhibits the reaction [kaempferol results in increased phosphorylation of MAPK1 protein]; kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; kaempferol inhibits the reaction [Paraquat results in increased phosphorylation of MAPK1 protein] kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK1 protein modified form]; kaempferol inhibits the reaction [propacetamol results in increased phosphorylation of MAPK1 protein] kaempferol inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK1 protein]; kaempferol inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]
|
CTD |
PMID:15832817 PMID:16014620 PMID:16041643 PMID:18346843 PMID:19265714 PMID:19367675 PMID:22155320 PMID:25177032 PMID:29574133 PMID:30499162 More...
|
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
|
|
G
|
Mapk14
|
mitogen activated protein kinase 14
|
multiple interactions
|
EXP
|
[kaempferol inhibits the reaction [Lipopolysaccharides co-treated with HIF1A protein]] which results in increased expression of MAPK14 protein; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased phosphorylation of MAPK14 protein
|
CTD |
PMID:36049518 |
|
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
|
|
G
|
Mapk3
|
mitogen activated protein kinase 3
|
increases activity increases phosphorylation multiple interactions
|
EXP ISO
|
kaempferol results in increased activity of MAPK3 protein kaempferol results in increased phosphorylation of MAPK3 protein 3',4'-dihydroxyflavone analog inhibits the reaction [kaempferol results in increased phosphorylation of MAPK3 protein]; kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]; kaempferol inhibits the reaction [Paraquat results in increased phosphorylation of MAPK3 protein] kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK3 protein modified form]; kaempferol inhibits the reaction [propacetamol results in increased phosphorylation of MAPK3 protein] kaempferol inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK3 protein]; kaempferol inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]
|
CTD |
PMID:15832817 PMID:16014620 PMID:16041643 PMID:18346843 PMID:19265714 PMID:19367675 PMID:22155320 PMID:25177032 PMID:29574133 PMID:30499162 More...
|
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
|
|
G
|
Mapk8
|
mitogen-activated protein kinase 8
|
increases phosphorylation
|
ISO
|
kaempferol results in increased phosphorylation of MAPK8 protein
|
CTD |
PMID:30499162 |
|
NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981
|
|
G
|
Mapk9
|
mitogen-activated protein kinase 9
|
increases phosphorylation
|
ISO
|
kaempferol results in increased phosphorylation of MAPK9 protein
|
CTD |
PMID:30499162 |
|
NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,169,675...34,210,178
|
|
G
|
Met
|
MET proto-oncogene, receptor tyrosine kinase
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [HGF protein results in increased phosphorylation of MET protein]
|
CTD |
PMID:19244381 |
|
NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
|
|
G
|
Mmp2
|
matrix metallopeptidase 2
|
multiple interactions decreases expression
|
ISO
|
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [kaempferol results in decreased expression of MMP2 protein]; kaempferol results in decreased expression of and results in decreased activity of MMP2 protein
|
CTD |
PMID:26408079 PMID:30499162 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
|
|
G
|
Mmp9
|
matrix metallopeptidase 9
|
decreases expression
|
ISO
|
kaempferol results in decreased expression of MMP9 protein
|
CTD |
PMID:34156145 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
|
|
G
|
Mt2
|
metallothionein 2
|
increases expression
|
ISO
|
kaempferol results in increased expression of MT2A mRNA
|
CTD |
PMID:10656621 |
|
NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
|
|
G
|
Muc5ac
|
mucin 5AC, oligomeric mucus/gel-forming
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [IL1B protein results in increased expression of MUC5AC mRNA]; kaempferol inhibits the reaction [Paraquat results in increased expression of MUC5AC mRNA]
|
CTD |
PMID:19367675 PMID:25177032 |
|
NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
|
|
G
|
Mybl1
|
MYB proto-oncogene like 1
|
multiple interactions increases expression
|
ISO
|
Fulvestrant inhibits the reaction [kaempferol results in increased expression of MYBL1 mRNA]
|
CTD |
PMID:33405908 |
|
NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183
|
|
G
|
Myl2
|
myosin light chain 2
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MYL2 protein]
|
CTD |
PMID:38823539 |
|
NCBI chr12:34,454,223...34,468,554
Ensembl chr12:34,454,218...34,468,983
|
|
G
|
Nanog
|
Nanog homeobox
|
increases expression decreases expression multiple interactions
|
ISO
|
kaempferol results in increased expression of NANOG protein kaempferol results in decreased expression of NANOG mRNA; kaempferol results in decreased expression of NANOG protein [Verapamil co-treated with kaempferol] results in decreased expression of NANOG mRNA; [Verapamil co-treated with kaempferol] results in decreased expression of NANOG protein
|
CTD |
PMID:26683311 PMID:35063459 |
|
NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116
|
|
G
|
Ncoa3
|
nuclear receptor coactivator 3
|
multiple interactions
|
ISO
|
kaempferol promotes the reaction [NCOA3 protein binds to GREB1 enhancer]
|
CTD |
PMID:20846786 |
|
NCBI chr 3:175,157,824...175,237,831
Ensembl chr 3:154,738,581...154,818,594
|
|
G
|
Nfe2l2
|
NFE2 like bZIP transcription factor 2
|
multiple interactions increases expression
|
ISO EXP
|
[kaempferol co-treated with Quercetin] results in increased expression of NFE2L2 mRNA; kaempferol inhibits the reaction [Benzo(a)pyrene results in increased expression of NFE2L2 mRNA] kaempferol inhibits the reaction [Chlorpyrifos results in decreased expression of NFE2L2 mRNA] kaempferol affects the reaction [propacetamol affects the expression of NFE2L2 protein] kaempferol results in increased expression of NFE2L2 mRNA
|
CTD |
PMID:21256954 PMID:25111660 PMID:29574133 PMID:30497708 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
|
|
G
|
Nfkbia
|
NFKB inhibitor alpha
|
decreases phosphorylation multiple interactions
|
ISO
|
kaempferol results in decreased phosphorylation of NFKBIA protein kaempferol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]
|
CTD |
PMID:17184768 PMID:20438634 PMID:30769083 PMID:36243145 |
|
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941
|
|
G
|
Nos2
|
nitric oxide synthase 2
|
decreases expression multiple interactions
|
ISO
|
kaempferol results in decreased expression of NOS2 mRNA; kaempferol results in decreased expression of NOS2 protein Hemin promotes the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; HMOX1 protein promotes the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]; kaempferol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; PPARG protein affects the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; tin protoporphyrin IX inhibits the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]] kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]
|
CTD |
PMID:11343698 PMID:12512693 PMID:14563492 PMID:15832817 PMID:16934226 PMID:17177504 PMID:17184768 PMID:18274639 PMID:18394220 PMID:19352036 PMID:30769083 PMID:31306686 More...
|
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G
|
Nos3
|
nitric oxide synthase 3
|
multiple interactions
|
EXP
|
[kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of NOS3 protein
|
CTD |
PMID:36049518 |
|
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
|
|
G
|
Nox4
|
NADPH oxidase 4
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [Paraquat results in increased expression of NOX4 mRNA]
|
CTD |
PMID:25177032 |
|
NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
|
|
G
|
Nqo1
|
NAD(P)H quinone dehydrogenase 1
|
multiple interactions
|
ISO
|
[pterostilbene co-treated with kaempferol] results in increased expression of NQO1 protein; [Quercetin co-treated with kaempferol] results in increased expression of NQO1 protein
|
CTD |
PMID:25111660 |
|
NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557
|
|
G
|
Nr1h4
|
nuclear receptor subfamily 1, group H, member 4
|
multiple interactions
|
ISO
|
kaempferol analog inhibits the reaction [Acetaminophen results in decreased expression of NR1H4 mRNA]
|
CTD |
PMID:36150480 |
|
NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
|
|
G
|
Nr1i2
|
nuclear receptor subfamily 1, group I, member 2
|
multiple interactions increases expression increases activity
|
ISO
|
[kaempferol results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; kaempferol binds to and results in increased activity of NR1I2 protein kaempferol results in increased expression of NR1I2 mRNA
|
CTD |
PMID:19034627 PMID:25455453 PMID:26238175 PMID:29933105 PMID:33049310 |
|
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
|
|
G
|
Nr1i3
|
nuclear receptor subfamily 1, group I, member 3
|
increases activity
|
ISO
|
kaempferol results in increased activity of NR1I3 protein
|
CTD |
PMID:19034627 |
|
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
|
|
G
|
Ocln
|
occludin
|
multiple interactions
|
ISO EXP
|
kaempferol inhibits the reaction [Ethanol results in decreased expression of OCLN protein]; kaempferol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of OCLN protein] [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in decreased expression of OCLN protein
|
CTD |
PMID:31785310 PMID:36049518 PMID:38823539 |
|
NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
|
|
G
|
Parp1
|
poly (ADP-ribose) polymerase 1
|
multiple interactions increases cleavage
|
EXP ISO
|
kaempferol inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein] 3',4'-dihydroxyflavone analog inhibits the reaction [kaempferol results in increased cleavage of PARP1 protein]
|
CTD |
PMID:16014620 PMID:22155320 |
|
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
|
|
G
|
Pcna
|
proliferating cell nuclear antigen
|
multiple interactions
|
EXP
|
[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with kaempferol] inhibits the reaction [Oxygen deficiency results in increased expression of PCNA protein]; kaempferol inhibits the reaction [Oxygen deficiency results in increased expression of PCNA mRNA]; kaempferol inhibits the reaction [Oxygen deficiency results in increased expression of PCNA protein]; kaempferol promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein]]
|
CTD |
PMID:29999212 PMID:36940862 |
|
NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995
|
|
G
|
Pdgfb
|
platelet derived growth factor subunit B
|
multiple interactions
|
EXP
|
kaempferol inhibits the reaction [PDGFB protein results in increased expression of FOS mRNA]; kaempferol inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]; kaempferol inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]; kaempferol inhibits the reaction [PDGFB protein results in increased phosphorylation of PLCG1 protein]
|
CTD |
PMID:16041643 |
|
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
|
|
G
|
Pdgfrb
|
platelet derived growth factor receptor beta
|
decreases phosphorylation
|
EXP
|
kaempferol results in decreased phosphorylation of PDGFRB protein
|
CTD |
PMID:16041643 |
|
NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843
|
|
G
|
Pgr
|
progesterone receptor
|
affects binding increases expression multiple interactions
|
ISO
|
kaempferol binds to PGR protein kaempferol results in increased expression of PGR mRNA ESR1 protein inhibits the reaction [kaempferol results in increased expression of PGR mRNA]; kaempferol inhibits the reaction [Progesterone binds to PGR protein]
|
CTD |
PMID:14579009 PMID:23384675 PMID:35307500 |
|
NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344
|
|
G
|
Pik3cg
|
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
|
multiple interactions
|
EXP
|
kaempferol inhibits the reaction [Oxygen deficiency results in increased expression of PIK3CG mRNA]; kaempferol inhibits the reaction [Oxygen deficiency results in increased expression of PIK3CG protein]
|
CTD |
PMID:37923178 |
|
NCBI chr 6:54,494,247...54,529,563
Ensembl chr 6:48,766,864...48,802,043
|
|
G
|
Plcg1
|
phospholipase C, gamma 1
|
multiple interactions
|
EXP
|
kaempferol inhibits the reaction [PDGFB protein results in increased phosphorylation of PLCG1 protein]
|
CTD |
PMID:16041643 |
|
NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330
|
|
G
|
Pou5f1
|
POU class 5 homeobox 1
|
decreases expression multiple interactions increases expression
|
ISO
|
kaempferol results in decreased expression of POU5F1 mRNA; kaempferol results in decreased expression of POU5F1 protein [Verapamil co-treated with kaempferol] results in decreased expression of POU5F1 mRNA; [Verapamil co-treated with kaempferol] results in decreased expression of POU5F1 protein kaempferol results in increased expression of POU5F1 protein
|
CTD |
PMID:22906706 PMID:26683311 PMID:35063459 |
|
NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
|
|
G
|
Pparg
|
peroxisome proliferator-activated receptor gamma
|
multiple interactions increases expression
|
ISO
|
kaempferol binds to and results in increased activity of PPARG protein; kaempferol inhibits the reaction [Rosiglitazone binds to and results in increased activity of PPARG protein]; PPARG protein affects the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; PPARG protein affects the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]] [kaempferol co-treated with Luteolin] inhibits the reaction [TGFB1 protein results in decreased expression of PPARG mRNA]; dorsomorphin inhibits the reaction [[kaempferol co-treated with Luteolin] inhibits the reaction [TGFB1 protein results in decreased expression of PPARG mRNA]]; kaempferol binds to and results in increased activity of PPARG protein kaempferol results in increased expression of PPARG mRNA; kaempferol results in increased expression of PPARG protein
|
CTD |
PMID:11343698 PMID:18262572 PMID:25765892 PMID:33049310 PMID:37308028 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
|
|
G
|
Ppargc1a
|
PPARG coactivator 1 alpha
|
increases expression
|
ISO
|
kaempferol results in increased expression of PPARGC1A mRNA
|
CTD |
PMID:17327447 |
|
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
|
|
G
|
Prkaa1
|
protein kinase AMP-activated catalytic subunit alpha 1
|
multiple interactions
|
ISO
|
[kaempferol co-treated with Luteolin] inhibits the reaction [TGFB1 protein results in decreased expression of PRKAA1 mRNA]; dorsomorphin inhibits the reaction [[kaempferol co-treated with Luteolin] inhibits the reaction [TGFB1 protein results in decreased expression of PRKAA1 mRNA]]
|
CTD |
PMID:37308028 |
|
NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
|
|
G
|
Psca
|
prostate stem cell antigen
|
decreases expression
|
ISO
|
kaempferol results in decreased expression of PSCA mRNA
|
CTD |
PMID:18331776 |
|
NCBI chr 7:106,598,203...106,603,114
Ensembl chr 7:106,595,284...106,609,746
|
|
G
|
Ptges
|
prostaglandin E synthase
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGES mRNA]
|
CTD |
PMID:21341175 |
|
NCBI chr 3:34,575,643...34,586,987
|
|
G
|
Ptgs2
|
prostaglandin-endoperoxide synthase 2
|
multiple interactions decreases expression
|
ISO
|
kaempferol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; PPARG protein affects the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]] kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of PTGS2 protein]; kaempferol inhibits the reaction [TGFA protein results in increased expression of PTGS2 mRNA] kaempferol results in decreased expression of PTGS2 mRNA; kaempferol results in decreased expression of PTGS2 protein
|
CTD |
PMID:10783318 PMID:11343698 PMID:17184768 PMID:18394220 PMID:19352036 PMID:21341175 PMID:30769083 PMID:31306686 PMID:37115092 More...
|
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
|
|
G
|
Pycard
|
PYD and CARD domain containing
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [Uric Acid promotes the reaction [PYCARD protein binds to PYCARD protein]]
|
CTD |
PMID:29960001 |
|
NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
|
|
G
|
Rbp4
|
retinol binding protein 4
|
decreases expression
|
ISO
|
kaempferol results in decreased expression of RBP4 protein
|
CTD |
PMID:30445784 |
|
NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399
|
|
G
|
Rela
|
RELA proto-oncogene, NF-kB subunit
|
multiple interactions
|
ISO EXP
|
kaempferol inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein]; kaempferol inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]; kaempferol inhibits the reaction [TNF protein results in increased localization of RELA protein] [kaempferol affects the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of RELA mRNA; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased phosphorylation of RELA protein kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RELA protein]
|
CTD |
PMID:16434028 PMID:18274639 PMID:20438634 PMID:30769083 PMID:36049518 PMID:36243145 More...
|
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G
|
Ripk1
|
receptor interacting serine/threonine kinase 1
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [propacetamol results in increased expression of RIPK1 protein]
|
CTD |
PMID:29574133 |
|
NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
|
|
G
|
Rpa3
|
replication protein A3
|
multiple interactions
|
ISO
|
[Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in increased expression of RPA3 mRNA
|
CTD |
PMID:16797527 |
|
NCBI chr 4:36,304,649...36,307,755
Ensembl chr 4:36,304,651...36,307,709
|
|
G
|
Runx2
|
RUNX family transcription factor 2
|
increases expression
|
ISO
|
kaempferol results in increased expression of RUNX2 mRNA
|
CTD |
PMID:23989061 |
|
NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
|
|
G
|
S1pr1
|
sphingosine-1-phosphate receptor 1
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of S1PR1 protein]
|
CTD |
PMID:38823539 |
|
NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681
|
|
G
|
Sele
|
selectin E
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of SELE protein]; kaempferol inhibits the reaction [TNF protein results in increased expression of SELE protein]
|
CTD |
PMID:16987811 PMID:18394220 |
|
NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
|
|
G
|
Sfn
|
stratifin
|
increases expression
|
ISO
|
kaempferol results in increased expression of SFN mRNA; kaempferol results in increased expression of SFN protein
|
CTD |
PMID:18331776 |
|
NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314
|
|
G
|
Slc16a1
|
solute carrier family 16 member 1
|
multiple interactions
|
EXP ISO
|
[kaempferol results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate kaempferol inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid]
|
CTD |
PMID:17108059 PMID:25719685 |
|
NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
|
|
G
|
Slc2a1
|
solute carrier family 2 member 1
|
decreases activity decreases expression multiple interactions
|
ISO
|
kaempferol results in decreased activity of SLC2A1 protein kaempferol results in decreased expression of SLC2A1 mRNA kaempferol inhibits the reaction [SLC2A1 protein affects the transport of Glucose]; kaempferol inhibits the reaction [SLC2A1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]
|
CTD |
PMID:14642735 PMID:25719685 PMID:36870413 |
|
NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
|
|
G
|
Slc2a4
|
solute carrier family 2 member 4
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein]
|
CTD |
PMID:18591783 |
|
NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
|
|
G
|
Slc5a8
|
solute carrier family 5 member 8
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [Ethanol results in decreased expression of SLC5A8 protein]
|
CTD |
PMID:31785310 |
|
NCBI chr 7:23,272,891...23,313,811
Ensembl chr 7:23,272,427...23,314,642
|
|
G
|
Slco1b2
|
solute carrier organic anion transporter family member 1B2
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]
|
CTD |
PMID:22394605 |
|
NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
|
|
G
|
Slco1c1
|
solute carrier organic anion transporter family, member 1c1
|
decreases activity multiple interactions
|
EXP
|
kaempferol results in decreased activity of SLCO1B1 protein [kaempferol results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [kaempferol results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Methotrexate
|
CTD |
PMID:32259555 |
|
NCBI chr 4:174,466,621...174,513,290
Ensembl chr 4:174,466,631...174,513,289
|
|
G
|
Sod1
|
superoxide dismutase 1
|
multiple interactions increases expression
|
ISO EXP
|
[pterostilbene co-treated with kaempferol] results in increased expression of SOD1 protein; [Quercetin co-treated with kaempferol] results in increased expression of SOD1 protein; kaempferol binds to and affects the folding of SOD1 protein mutant form kaempferol inhibits the reaction [Oxygen deficiency results in decreased expression of SOD1 protein] kaempferol results in increased expression of SOD1 protein
|
CTD |
PMID:25111660 PMID:30260512 PMID:37923178 |
|
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
|
|
G
|
Sod2
|
superoxide dismutase 2
|
multiple interactions affects response to substance increases expression
|
ISO
|
fulvestrant inhibits the reaction [kaempferol results in increased expression of SOD2 protein] SOD2 protein affects the susceptibility to kaempferol
|
CTD |
PMID:23526725 |
|
NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189
|
|
G
|
Sox2
|
SRY-box transcription factor 2
|
multiple interactions decreases expression
|
ISO
|
[Verapamil co-treated with kaempferol] results in decreased expression of SOX2 mRNA kaempferol results in decreased expression of SOX2 mRNA
|
CTD |
PMID:35063459 |
|
NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338
|
|
G
|
Sox9
|
SRY-box transcription factor 9
|
increases expression
|
ISO
|
kaempferol results in increased expression of SOX9 mRNA
|
CTD |
PMID:23989061 |
|
NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994
|
|
G
|
Sphk1
|
sphingosine kinase 1
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of SPHK1 protein]; kaempferol inhibits the reaction [Lipopolysaccharides affects the expression of SPHK1 protein]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of SPHK1 protein] kaempferol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of SPHK1 protein]; kaempferol inhibits the reaction [Lipopolysaccharides results in decreased expression of SPHK1 protein]
|
CTD |
PMID:36243145 PMID:38823539 |
|
NCBI chr10:102,257,413...102,263,086
Ensembl chr10:101,758,711...101,764,240
|
|
G
|
Spp1
|
secreted phosphoprotein 1
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [APOE affects the expression of SPP1 mRNA]; kaempferol inhibits the reaction [APOE affects the expression of SPP1 protein]
|
CTD |
PMID:22005275 |
|
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
|
|
G
|
Stat1
|
signal transducer and activator of transcription 1
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of STAT1 protein alternative form]
|
CTD |
PMID:18274639 |
|
NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
|
|
G
|
Stat2
|
signal transducer and activator of transcription 2
|
multiple interactions
|
ISO
|
[Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in decreased expression of STAT2 mRNA
|
CTD |
PMID:16797527 |
|
NCBI chr 7:702,565...718,349
Ensembl chr 7:702,495...718,967
|
|
G
|
Tfam
|
transcription factor A, mitochondrial
|
increases expression
|
ISO
|
kaempferol results in increased expression of TFAM mRNA
|
CTD |
PMID:17327447 |
|
NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
|
|
G
|
Tff1
|
trefoil factor 1
|
increases expression multiple interactions
|
ISO
|
kaempferol results in increased expression of TFF1 mRNA ESR1 protein inhibits the reaction [kaempferol results in increased expression of TFF1 mRNA]
|
CTD |
PMID:14706564 PMID:23384675 PMID:35307500 |
|
NCBI chr20:9,237,095...9,240,956
Ensembl chr20:9,235,736...9,239,597
|
|
G
|
Tgfa
|
transforming growth factor alpha
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [TGFA protein results in increased expression of PTGS2 mRNA]
|
CTD |
PMID:10783318 |
|
NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
|
|
G
|
Tgfb1
|
transforming growth factor, beta 1
|
multiple interactions
|
ISO
|
[kaempferol co-treated with Luteolin] inhibits the reaction [TGFB1 protein results in decreased expression of PPARG mRNA]; [kaempferol co-treated with Luteolin] inhibits the reaction [TGFB1 protein results in decreased expression of PRKAA1 mRNA]; [kaempferol co-treated with Luteolin] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; [kaempferol co-treated with Luteolin] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; dorsomorphin inhibits the reaction [[kaempferol co-treated with Luteolin] inhibits the reaction [TGFB1 protein results in decreased expression of PPARG mRNA]]; dorsomorphin inhibits the reaction [[kaempferol co-treated with Luteolin] inhibits the reaction [TGFB1 protein results in decreased expression of PRKAA1 mRNA]]; dorsomorphin inhibits the reaction [[kaempferol co-treated with Luteolin] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]]; kaempferol inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
|
CTD |
PMID:37308028 |
|
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
|
|
G
|
Tjp1
|
tight junction protein 1
|
multiple interactions
|
ISO EXP
|
kaempferol inhibits the reaction [Ethanol results in decreased expression of TJP1 protein]; kaempferol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of TJP1 protein] [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in decreased expression of TJP1 protein
|
CTD |
PMID:31785310 PMID:36049518 PMID:38823539 |
|
NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
|
|
G
|
Tnf
|
tumor necrosis factor
|
multiple interactions decreases expression decreases activity
|
ISO EXP
|
kaempferol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; kaempferol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; kaempferol inhibits the reaction [propacetamol results in increased expression of TNF protein]; kaempferol inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; kaempferol inhibits the reaction [TNF protein results in increased localization of RELA protein]; kaempferol inhibits the reaction [TNF protein results in increased secretion of CCL2 protein]; kaempferol inhibits the reaction [TNF protein results in increased secretion of IL6 protein] kaempferol results in decreased expression of TNF protein [kaempferol affects the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of RELA mRNA; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in decreased expression of OCLN protein; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in decreased expression of TJP1 protein; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in decreased secretion of IL10 protein; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of BAD protein; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of CASP9 protein; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of CLDN2 protein; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of FGF2 protein; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of IL6 mRNA; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of KDR mRNA; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of KDR protein; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of NOS3 protein; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of VEGFA mRNA; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of VEGFA protein; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased phosphorylation of HSPB1 protein; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased phosphorylation of MAPK14 protein; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased phosphorylation of RELA protein; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased secretion of IL6 protein; kaempferol inhibits the reaction [Oxaliplatin results in increased expression of TNF mRNA]; kaempferol inhibits the reaction [Oxaliplatin results in increased expression of TNF protein]; kaempferol inhibits the reaction [Oxygen deficiency results in increased expression of TNF protein] kaempferol results in decreased activity of TNF protein kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of ICAM1 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of PTGS2 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of SELE protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of VCAM1 protein]; kaempferol inhibits the reaction [IL32 protein results in increased expression of TNF mRNA]; kaempferol inhibits the reaction [IL32 protein results in increased secretion of TNF protein]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; kaempferol inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; kaempferol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; kaempferol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; kaempferol inhibits the reaction [TNF protein results in increased expression of JUN mRNA]; kaempferol inhibits the reaction [TNF protein results in increased expression of SELE protein]
|
CTD |
PMID:15322261 PMID:15985724 PMID:16434028 PMID:16934226 PMID:16987811 PMID:18394220 PMID:20438634 PMID:28711657 PMID:29574133 PMID:30445784 PMID:30769083 PMID:31306686 PMID:35574720 PMID:36049518 PMID:36243145 PMID:37923178 PMID:38823539 More...
|
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G
|
Tnfaip3
|
TNF alpha induced protein 3
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA]
|
CTD |
PMID:20438634 |
|
NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:13,709,206...13,725,282
|
|
G
|
Tnfrsf11a
|
TNF receptor superfamily member 11A
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A mRNA]
|
CTD |
PMID:16434028 |
|
NCBI chr13:21,928,370...21,986,719
Ensembl chr13:21,928,408...21,986,695
|
|
G
|
Tnfsf11
|
TNF superfamily member 11
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA]; kaempferol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; kaempferol inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A mRNA]
|
CTD |
PMID:16434028 |
|
NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445
|
|
G
|
Tp53
|
tumor protein p53
|
multiple interactions decreases expression affects response to substance increases phosphorylation increases expression
|
ISO EXP
|
Caffeine inhibits the reaction [kaempferol results in increased phosphorylation of TP53 protein]; TP53 protein affects the reaction [kaempferol promotes the reaction [BBC3 protein binds to BCL2L1 protein]] kaempferol results in decreased expression of TP53 protein kaempferol inhibits the reaction [Doxorubicin promotes the reaction [TP53 protein binds to BAX promoter]]; kaempferol inhibits the reaction [Doxorubicin results in increased expression of TP53 mRNA] TP53 protein affects the susceptibility to kaempferol kaempferol results in increased expression of TP53 protein
|
CTD |
PMID:19028473 PMID:22155320 PMID:37115092 |
|
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
|
|
G
|
Tp53i3
|
tumor protein p53 inducible protein 3
|
increases expression
|
ISO
|
kaempferol results in increased expression of TP53I3 mRNA; kaempferol results in increased expression of TP53I3 protein
|
CTD |
PMID:18331776 PMID:19397994 |
|
NCBI chr 6:27,818,327...27,825,753
|
|
G
|
Tp63
|
tumor protein p63
|
increases expression
|
ISO
|
kaempferol results in increased expression of TP63 protein
|
CTD |
PMID:18331776 PMID:19397994 |
|
NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398
|
|
G
|
Tp73
|
tumor protein p73
|
increases expression
|
ISO
|
kaempferol results in increased expression of TP73 protein
|
CTD |
PMID:18331776 PMID:19397994 |
|
NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128
|
|
G
|
Traf6
|
TNF receptor associated factor 6
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [IL1B protein results in increased ubiquitination of TRAF6 protein]
|
CTD |
PMID:30769083 |
|
NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:87,963,514...87,983,507
|
|
G
|
Tslp
|
thymic stromal lymphopoietin
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [IL32 protein results in increased expression of TSLP mRNA]; kaempferol inhibits the reaction [IL32 protein results in increased secretion of TSLP protein]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased secretion of TSLP protein]
|
CTD |
PMID:28711657 |
|
NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548
|
|
G
|
Tubb3
|
tubulin, beta 3 class III
|
decreases expression
|
ISO
|
kaempferol results in decreased expression of TUBB3 protein
|
CTD |
PMID:26683311 |
|
NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243
|
|
G
|
Ucp1
|
uncoupling protein 1
|
multiple interactions
|
EXP
|
kaempferol inhibits the reaction [Dietary Fats results in decreased expression of UCP1 mRNA]
|
CTD |
PMID:30372826 |
|
NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852
|
|
G
|
Ucp3
|
uncoupling protein 3
|
increases expression
|
ISO
|
kaempferol results in increased expression of UCP3 mRNA
|
CTD |
PMID:17327447 |
|
NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762
|
|
G
|
Ugt1a1
|
UDP glucuronosyltransferase family 1 member A1
|
increases glucuronidation decreases activity multiple interactions
|
ISO
|
UGT1A1 protein results in increased glucuronidation of kaempferol kaempferol results in decreased activity of UGT1A1 protein kaempferol inhibits the reaction [propacetamol results in decreased expression of UGT1A1 protein]
|
CTD |
PMID:14557274 PMID:29574133 PMID:35063619 |
|
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
|
|
G
|
Ugt1a2
|
UDP glucuronosyltransferase 1 family, polypeptide A2
|
increases glucuronidation decreases activity affects glucuronidation
|
ISO
|
UGT1A3 protein results in increased glucuronidation of kaempferol kaempferol results in decreased activity of UGT1A3 protein UGT1A3 mutant form affects the glucuronidation of kaempferol
|
CTD |
PMID:16738032 PMID:35063619 |
|
NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
|
|
G
|
Ugt1a9
|
UDP glucuronosyltransferase family 1 member A9
|
increases glucuronidation decreases activity
|
ISO
|
UGT1A9 protein results in increased glucuronidation of kaempferol kaempferol results in decreased activity of UGT1A9 protein
|
CTD |
PMID:14557274 PMID:35063619 |
|
NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
|
|
G
|
Ugt2b7
|
UDP glucuronosyltransferase family 2 member B7
|
decreases activity
|
ISO
|
kaempferol results in decreased activity of UGT2B7 protein
|
CTD |
PMID:35063619 |
|
NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
|
|
G
|
Utrn
|
utrophin
|
increases expression
|
ISO
|
kaempferol results in increased expression of UTRN mRNA
|
CTD |
PMID:22028826 |
|
NCBI chr 1:8,541,061...9,044,487
Ensembl chr 1:6,722,594...7,224,313
|
|
G
|
Vcam1
|
vascular cell adhesion molecule 1
|
multiple interactions
|
ISO
|
kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of VCAM1 protein]
|
CTD |
PMID:18394220 |
|
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
|
|
G
|
Vdr
|
vitamin D receptor
|
increases activity
|
ISO
|
kaempferol results in increased activity of VDR protein
|
CTD |
PMID:26366751 |
|
NCBI chr 7:130,864,764...130,916,757
Ensembl chr 7:128,987,981...129,037,677
|
|
G
|
Vegfa
|
vascular endothelial growth factor A
|
multiple interactions decreases expression
|
ISO EXP
|
kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA] kaempferol results in decreased expression of VEGFA protein [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with HIF1A protein]] which results in increased expression of VEGFA protein; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of VEGFA mRNA; [kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in increased expression of VEGFA protein
|
CTD |
PMID:20438634 PMID:36049518 PMID:37115092 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
|
|
|
G
|
Mitf
|
melanocyte inducing transcription factor
|
increases expression
|
ISO
|
afzelin results in increased expression of MITF mRNA; afzelin results in increased expression of MITF protein
|
CTD |
PMID:27287415 |
|
NCBI chr 4:131,965,676...132,177,790
Ensembl chr 4:130,409,217...130,621,145
|
|
G
|
Tyr
|
tyrosinase
|
multiple interactions increases expression
|
ISO
|
afzelin results in increased expression of and results in increased activity of TYR protein afzelin results in increased expression of TYR mRNA
|
CTD |
PMID:27287415 |
|
NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
|
|
G
|
Tyrp1
|
tyrosinase-related protein 1
|
increases expression
|
ISO
|
afzelin results in increased expression of TYRP1 mRNA; afzelin results in increased expression of TYRP1 protein
|
CTD |
PMID:27287415 |
|
NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516
|
|
|
G
|
Bax
|
BCL2 associated X, apoptosis regulator
|
multiple interactions
|
EXP
|
herbacetin inhibits the reaction [Cyclophosphamide results in increased expression of BAX mRNA]
|
CTD |
PMID:36198566 |
|
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
|
|
G
|
Bcl2
|
BCL2, apoptosis regulator
|
multiple interactions
|
EXP
|
herbacetin inhibits the reaction [Cyclophosphamide results in decreased expression of BCL2 mRNA]
|
CTD |
PMID:36198566 |
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
|
|
G
|
Casp3
|
caspase 3
|
multiple interactions
|
EXP
|
herbacetin inhibits the reaction [Cyclophosphamide results in increased expression of CASP3 mRNA]
|
CTD |
PMID:36198566 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
|
|
G
|
Cat
|
catalase
|
multiple interactions
|
EXP
|
herbacetin inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]
|
CTD |
PMID:36198566 |
|
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
|
|
G
|
Fasn
|
fatty acid synthase
|
multiple interactions
|
ISO
|
herbacetin inhibits the reaction [Dietary Fats results in increased activity of FASN protein]
|
CTD |
PMID:29653099 |
|
NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261
|
|
G
|
G6pd
|
glucose-6-phosphate dehydrogenase
|
multiple interactions
|
ISO
|
herbacetin inhibits the reaction [Dietary Fats results in increased activity of G6PD protein]
|
CTD |
PMID:29653099 |
|
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
|
|
G
|
Gpt
|
glutamic--pyruvic transaminase
|
multiple interactions
|
ISO
|
herbacetin inhibits the reaction [Dietary Fats results in increased activity of GPT protein]
|
CTD |
PMID:29653099 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
|
|
G
|
Gsr
|
glutathione-disulfide reductase
|
multiple interactions
|
EXP
|
herbacetin inhibits the reaction [Cyclophosphamide results in decreased activity of GSR protein]
|
CTD |
PMID:36198566 |
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
|
|
G
|
Havcr1
|
hepatitis A virus cellular receptor 1
|
multiple interactions
|
EXP
|
herbacetin inhibits the reaction [Cyclophosphamide results in increased expression of HAVCR1 protein]
|
CTD |
PMID:36198566 |
|
NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
|
|
G
|
Il1b
|
interleukin 1 beta
|
multiple interactions
|
EXP
|
herbacetin inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]
|
CTD |
PMID:36198566 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G
|
Il6
|
interleukin 6
|
multiple interactions
|
EXP
|
herbacetin inhibits the reaction [Cyclophosphamide results in increased expression of IL6 protein]
|
CTD |
PMID:36198566 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G
|
Lcn2
|
lipocalin 2
|
multiple interactions
|
EXP
|
herbacetin inhibits the reaction [Cyclophosphamide results in increased expression of LCN2 protein]
|
CTD |
PMID:36198566 |
|
NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
|
|
G
|
Nos2
|
nitric oxide synthase 2
|
multiple interactions
|
EXP
|
herbacetin inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein]
|
CTD |
PMID:36198566 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G
|
Ptgs2
|
prostaglandin-endoperoxide synthase 2
|
multiple interactions
|
EXP
|
herbacetin inhibits the reaction [Cyclophosphamide results in increased expression of PTGS2 protein]
|
CTD |
PMID:36198566 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
|
|
G
|
Srebf1
|
sterol regulatory element binding transcription factor 1
|
multiple interactions
|
ISO
|
herbacetin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]
|
CTD |
PMID:29653099 |
|
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
|
|
G
|
Srebf2
|
sterol regulatory element binding transcription factor 2
|
multiple interactions
|
ISO
|
herbacetin inhibits the reaction [Dietary Fats results in increased expression of SREBF2 mRNA]
|
CTD |
PMID:29653099 |
|
NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
|
|
G
|
Tnf
|
tumor necrosis factor
|
multiple interactions
|
EXP
|
herbacetin inhibits the reaction [Cyclophosphamide results in increased expression of TNF protein]
|
CTD |
PMID:36198566 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
|
G
|
Abcb1a
|
ATP binding cassette subfamily B member 1A
|
multiple interactions
|
ISO
|
kaempferide inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; kaempferide inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]]
|
CTD |
PMID:34217736 |
|
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
|
|
G
|
Slc2a1
|
solute carrier family 2 member 1
|
decreases expression
|
ISO
|
kaempferide results in decreased expression of SLC2A1 mRNA
|
CTD |
PMID:21865046 |
|
NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
|
|
G
|
Sod1
|
superoxide dismutase 1
|
multiple interactions
|
ISO
|
kaempferide binds to and affects the folding of SOD1 protein mutant form
|
CTD |
PMID:30260512 |
|
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
|
|
G
|
Vegfa
|
vascular endothelial growth factor A
|
increases expression
|
ISO
|
kaempferide results in increased expression of VEGFA mRNA
|
CTD |
PMID:21865046 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
|
|
|
G
|
Pla2g2a
|
phospholipase A2 group IIA
|
affects activity
|
ISO
|
kaempferol-3-O-galactoside affects the activity of PLA2G2A protein
|
CTD |
PMID:8190018 |
|
NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014
|
|
|
G
|
App
|
amyloid beta precursor protein
|
multiple interactions
|
ISO
|
astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in decreased expression of APP protein]
|
CTD |
PMID:35537655 |
|
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
|
|
G
|
Cat
|
catalase
|
multiple interactions
|
ISO
|
astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in decreased expression of CAT protein]
|
CTD |
PMID:35537655 |
|
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
|
|
G
|
Ccl2
|
C-C motif chemokine ligand 2
|
multiple interactions
|
ISO
|
astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]
|
CTD |
PMID:22210036 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
|
|
G
|
Ccl3
|
C-C motif chemokine ligand 3
|
multiple interactions
|
ISO
|
astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 mRNA]
|
CTD |
PMID:22210036 |
|
NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
|
|
G
|
Hes1
|
hes family bHLH transcription factor 1
|
multiple interactions
|
ISO
|
astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of HES1 protein]
|
CTD |
PMID:35537655 |
|
NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
|
|
G
|
Il10
|
interleukin 10
|
multiple interactions
|
ISO
|
astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in decreased expression of IL10 protein]
|
CTD |
PMID:35537655 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
|
|
G
|
Il1b
|
interleukin 1 beta
|
multiple interactions
|
ISO
|
astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of IL1B protein]; astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
|
CTD |
PMID:22210036 PMID:35537655 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G
|
Il6
|
interleukin 6
|
multiple interactions
|
ISO
|
astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of IL6 protein]; astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] astragalin inhibits the reaction [Bleomycin results in increased secretion of IL6 protein]
|
CTD |
PMID:22210036 PMID:28299617 PMID:35537655 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G
|
Nfkbia
|
NFKB inhibitor alpha
|
multiple interactions
|
ISO
|
astragalin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]
|
CTD |
PMID:22210036 |
|
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941
|
|
G
|
Nos2
|
nitric oxide synthase 2
|
multiple interactions
|
ISO
|
astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
|
CTD |
PMID:22210036 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G
|
Notch1
|
notch receptor 1
|
multiple interactions
|
ISO
|
astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of NOTCH1 protein]
|
CTD |
PMID:35537655 |
|
NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
|
|
G
|
Ptgs2
|
prostaglandin-endoperoxide synthase 2
|
multiple interactions
|
ISO
|
astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
|
CTD |
PMID:22210036 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
|
|
G
|
Rbpj
|
recombination signal binding protein for immunoglobulin kappa J region
|
multiple interactions
|
ISO
|
astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of RBPJ protein]
|
CTD |
PMID:35537655 |
|
NCBI chr14:57,338,493...57,523,330
Ensembl chr14:57,338,507...57,523,353
|
|
G
|
Rela
|
RELA proto-oncogene, NF-kB subunit
|
multiple interactions
|
ISO
|
astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of and results in increased phosphorylation of RELA protein]; astragalin inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]
|
CTD |
PMID:22210036 PMID:35537655 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G
|
Tnf
|
tumor necrosis factor
|
multiple interactions
|
ISO
|
astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of TNF protein]; astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
|
CTD |
PMID:22210036 PMID:35537655 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
|
G
|
Abcc1
|
ATP binding cassette subfamily C member 1
|
affects activity
|
ISO
|
robinin affects the activity of ABCC1 protein
|
CTD |
PMID:15796199 |
|
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
|
|
G
|
Rgs2
|
regulator of G-protein signaling 2
|
multiple interactions
|
EXP
|
robinin inhibits the reaction [Particulate Matter results in decreased expression of RGS2 protein]
|
CTD |
PMID:38777097 |
|
NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
|
|
G
|
Tlr2
|
toll-like receptor 2
|
multiple interactions
|
EXP
|
robinin inhibits the reaction [Particulate Matter results in increased expression of TLR2 mRNA]
|
CTD |
PMID:38777097 |
|
NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:169,197,419...169,206,630
|
|
G
|
Tlr4
|
toll-like receptor 4
|
multiple interactions
|
EXP
|
robinin inhibits the reaction [Particulate Matter results in increased expression of TLR4 mRNA]
|
CTD |
PMID:38777097 |
|
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
|
|