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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:kaempferol
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Accession:CHEBI:28499 term browser browse the term
Definition:A tetrahydroxyflavone in which the four hydroxy groups are located at positions 3, 5, 7 and 4'. Acting as an antioxidant by reducing oxidative stress, it is currently under consideration as a possible cancer treatment.
Synonyms:related_synonym: 3,4',5,7-Tetrahydroxyflavone;   3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one;   4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-5,7,4'-Trihydroxyflavonol;   5,7,4'-trihydroxyflavonol;   C.I. 75640;   Formula=C15H10O6;   InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H;   InChIKey=IYRMWMYZSQPJKC-UHFFFAOYSA-N;   Indigo yellow;   Kaempherol;   Kampherol;   Kempferol;   Nimbecetin;   Pelargidenolon;   Populnetin;   Rhamnolutein;   Rhamnolutin;   Robigenin;   SMILES=Oc1ccc(cc1)-c1oc2cc(O)cc(O)c2c(=O)c1O;   Swartziol;   Trifolitin;   campherol
 alt_id: CHEBI:24944;   CHEBI:43598;   CHEBI:6100
 xref: Beilstein:304401;   CAS:520-18-3;   DrugBank:DB01852;   HMDB:HMDB0005801;   KEGG:C05903;   KNApSAcK:C00004565;   LINCS:LSM-5304;   LIPID_MAPS_instance:LMPK12110003
 xref_mesh: MESH:C006552
 xref: MetaCyc:CPD1F-90;   PDBeChem:KMP;   PMID:12592675;   PMID:15234754;   PMID:17426744;   PMID:28166217;   Reaxys:304401;   Wikipedia:kaempferol
 cyclic_relationship: is_conjugate_acid_of CHEBI:58573


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kaempferol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
multiple interactions
ISO ABCB1 protein results in increased transport of kaempferol
kaempferol inhibits the reaction [[ABCB1 protein results in decreased susceptibility to Doxorubicin] promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA]]; kaempferol inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]
CTD PMID:15266218, PMID:15969930, PMID:20438634 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity
increases activity
multiple interactions
affects activity
ISO kaempferol results in decreased activity of ABCC1 protein
kaempferol results in increased activity of ABCC1 protein
kaempferol affects the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; kaempferol inhibits the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]
kaempferol affects the activity of ABCC1 protein
CTD PMID:11306701, PMID:15670588, PMID:15796199 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression ISO kaempferol results in decreased expression of ACTA2 protein CTD PMID:26683311 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Afp alpha-fetoprotein affects binding
decreases expression
EXP
ISO
kaempferol binds to AFP protein
kaempferol results in decreased expression of AFP protein
CTD PMID:23013281, PMID:25349334, PMID:26683311 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Ahr aryl hydrocarbon receptor affects binding
multiple interactions
increases activity
ISO kaempferol binds to AHR protein
kaempferol inhibits the reaction [beta-Naphthoflavone promotes the reaction [AHR protein binds to ARNT protein]]; kaempferol inhibits the reaction [beta-Naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [AHR protein binds to AIP protein]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of AHR protein]
kaempferol results in increased activity of AHR protein
kaempferol inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1B1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1B1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AHR protein]
CTD PMID:10359656, PMID:14644660, PMID:17012224, PMID:19034627, PMID:19794518, PMID:20450880, PMID:20846786 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Aip aryl-hydrocarbon receptor-interacting protein multiple interactions ISO kaempferol inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [AHR protein binds to AIP protein]] CTD PMID:20450880 NCBI chr 1:219,361,859...219,373,924
Ensembl chr 1:219,361,860...219,374,014
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO kaempferol inhibits the reaction [HGF protein results in increased phosphorylation of AKT1 protein]; kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of AKT1 protein]
kaempferol results in decreased phosphorylation of AKT1 protein
kaempferol inhibits the reaction [INS1 protein results in increased activity of AKT1 protein]
CTD PMID:18591783, PMID:19244381, PMID:20438634 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type decreases activity
multiple interactions
ISO kaempferol results in decreased activity of ALOX12 protein
kaempferol inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid]
CTD PMID:17027136 NCBI chr10:56,851,734...56,864,049
Ensembl chr10:56,851,734...56,864,005
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions ISO kaempferol inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4] CTD PMID:18096136 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Apoe apolipoprotein E multiple interactions ISO kaempferol inhibits the reaction [APOE affects the expression of CD44 mRNA]; kaempferol inhibits the reaction [APOE affects the expression of CD44 protein]; kaempferol inhibits the reaction [APOE affects the expression of SPP1 mRNA]; kaempferol inhibits the reaction [APOE affects the expression of SPP1 protein] CTD PMID:22005275 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G App amyloid beta precursor protein multiple interactions EXP kaempferol inhibits the reaction [APP protein binds to APP protein] CTD PMID:17323972 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Ar androgen receptor multiple interactions ISO kaempferol inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein] CTD PMID:29162470 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO kaempferol inhibits the reaction [beta-Naphthoflavone promotes the reaction [AHR protein binds to ARNT protein]]; kaempferol inhibits the reaction [beta-Naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]
kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein]
CTD PMID:17012224, PMID:20450880, PMID:20846786 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Atm ATM serine/threonine kinase multiple interactions
increases phosphorylation
ISO Caffeine inhibits the reaction [kaempferol results in increased phosphorylation of ATM protein] CTD PMID:19028473 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G B3galt5 Beta-1,3-galactosyltransferase 5 decreases expression ISO kaempferol results in decreased expression of B3GALT5 protein CTD PMID:22906706 NCBI chr11:36,638,067...36,683,915
Ensembl chr11:36,634,662...36,683,672
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO
EXP
kaempferol results in increased expression of BAX protein
kaempferol inhibits the reaction [propacetamol results in increased expression of BAX protein]
kaempferol inhibits the reaction [Doxorubicin promotes the reaction [TP53 protein binds to BAX promoter]]; kaempferol inhibits the reaction [Doxorubicin results in increased expression of BAX mRNA]
CTD PMID:19028473, PMID:22155320, PMID:29574133 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions
increases expression
ISO Caffeine inhibits the reaction [kaempferol results in increased expression of BBC3 protein]; kaempferol promotes the reaction [BBC3 protein binds to BCL2L1 protein]; TP53 protein affects the reaction [kaempferol promotes the reaction [BBC3 protein binds to BCL2L1 protein]] CTD PMID:19028473 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO kaempferol results in decreased expression of BCL2 protein CTD PMID:19028473 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions ISO kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2A1 mRNA] CTD PMID:20438634 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO kaempferol promotes the reaction [BBC3 protein binds to BCL2L1 protein]; TP53 protein affects the reaction [kaempferol promotes the reaction [BBC3 protein binds to BCL2L1 protein]] CTD PMID:19028473 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression ISO kaempferol results in increased expression of BMP2 mRNA; kaempferol results in increased expression of BMP2 protein CTD PMID:23989061 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
JBrowse link
G Bmp4 bone morphogenetic protein 4 increases expression ISO kaempferol results in increased expression of BMP4 mRNA CTD PMID:23989061 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Calcr calcitonin receptor multiple interactions ISO kaempferol inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA] CTD PMID:16434028 NCBI chr 4:28,627,439...28,702,559
Ensembl chr 4:28,627,442...28,702,559
JBrowse link
G Casp1 caspase 1 multiple interactions ISO kaempferol inhibits the reaction [IL32 protein results in increased expression of and results in increased activity of CASP1 protein] CTD PMID:28711657 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
EXP
ISO
kaempferol inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]; kaempferol promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of CASP3 protein]]
kaempferol inhibits the reaction [propacetamol results in increased cleavage of CASP3 protein]; kaempferol inhibits the reaction [Rotenone results in increased cleavage of CASP3 protein]
kaempferol results in increased cleavage of CASP3 protein
3',4'-dihydroxyflavone analog inhibits the reaction [kaempferol results in increased cleavage of CASP3 protein]; kaempferol inhibits the reaction [Rotenone results in increased cleavage of CASP3 protein]
CTD PMID:16014620, PMID:18331776, PMID:19028473, PMID:19397994, PMID:20594614, PMID:22155320, PMID:29574133, PMID:29999212 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions
ISO kaempferol results in increased cleavage of CASP9 protein
kaempferol inhibits the reaction [Rotenone results in increased cleavage of CASP9 protein]
CTD PMID:18331776, PMID:20594614 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions EXP
ISO
kaempferol inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; kaempferol inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]
kaempferol inhibits the reaction [propacetamol results in decreased activity of CAT protein]
CTD PMID:22155320, PMID:29574133, PMID:30372826 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cckar cholecystokinin A receptor multiple interactions EXP kaempferol inhibits the reaction [8-sulfocholecystokinin octapeptide results in increased activity of CCKAR protein] CTD PMID:24630973 NCBI chr14:59,610,939...59,619,786
Ensembl chr14:59,611,434...59,619,783
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO kaempferol inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]; kaempferol inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; kaempferol inhibits the reaction [TNF protein results in increased secretion of CCL2 protein]
kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCL2 mRNA]
CTD PMID:16434028, PMID:20438634, PMID:31306686 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO [Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in decreased expression of CCL5 mRNA CTD PMID:16797527 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccn5 cellular communication network factor 5 increases expression
multiple interactions
ISO kaempferol results in increased expression of CCN5 mRNA
ESR1 protein inhibits the reaction [kaempferol results in increased expression of CCN5 mRNA]
CTD PMID:23384675 NCBI chr 3:160,207,969...160,219,316
Ensembl chr 3:160,207,913...160,219,331
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO kaempferol results in decreased expression of CCNB1 mRNA; kaempferol results in decreased expression of CCNB1 protein CTD PMID:18331776, PMID:19397994 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCND1 mRNA] CTD PMID:20438634 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cd14 CD14 molecule multiple interactions ISO kaempferol inhibits the reaction [IL32 protein results in increased expression of CD14 mRNA]; kaempferol inhibits the reaction [IL32 protein results in increased expression of CD14 protein] CTD PMID:28711657 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cd44 CD44 molecule (Indian blood group) multiple interactions ISO kaempferol inhibits the reaction [APOE affects the expression of CD44 mRNA]; kaempferol inhibits the reaction [APOE affects the expression of CD44 protein]
kaempferol inhibits the reaction [IL32 protein results in increased expression of CD44 protein]
CTD PMID:22005275, PMID:28711657 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO kaempferol results in increased phosphorylation of and results in decreased activity of CDK1 protein CTD PMID:11322924 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO kaempferol results in increased expression of CDKN1A mRNA; kaempferol results in increased expression of CDKN1A protein CTD PMID:19397994 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C decreases expression ISO kaempferol results in decreased expression of CDKN2C mRNA CTD PMID:18331776 NCBI chr 5:129,347,731...129,352,886
Ensembl chr 5:129,347,732...129,352,886
JBrowse link
G Cftr CF transmembrane conductance regulator affects localization ISO kaempferol affects the localization of CFTR protein mutant form CTD PMID:15191910 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Chek1 checkpoint kinase 1 increases phosphorylation ISO kaempferol results in increased phosphorylation of CHEK1 protein CTD PMID:24595819 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chek2 checkpoint kinase 2 increases phosphorylation ISO kaempferol results in increased phosphorylation of CHEK2 protein CTD PMID:24595819 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex decreases phosphorylation
multiple interactions
ISO kaempferol results in decreased phosphorylation of CHUK protein
kaempferol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein]
CTD PMID:17184768, PMID:30769083 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Col10a1 collagen type X alpha 1 chain increases expression ISO kaempferol results in increased expression of COL10A1 mRNA CTD PMID:23989061 NCBI chr20:41,180,295...41,190,664
Ensembl chr20:41,184,287...41,189,633
JBrowse link
G Col2a1 collagen type II alpha 1 chain increases expression ISO kaempferol results in increased expression of COL2A1 mRNA CTD PMID:23989061 NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions EXP kaempferol inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA] CTD PMID:30372826 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Crp C-reactive protein decreases expression ISO kaempferol results in decreased expression of CRP mRNA; kaempferol results in decreased expression of CRP protein CTD PMID:17184768 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Cs citrate synthase increases activity ISO kaempferol results in increased activity of CS protein CTD PMID:31306686 NCBI chr 7:2,752,680...2,778,963
Ensembl chr 7:2,752,680...2,778,963
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions
increases secretion
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; bisindolylmaleimide I inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Brefeldin A inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Colchicine inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Cytochalasin B inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Egtazic Acid inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Monensin inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Nocodazole inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; U 0126 inhibits the reaction [kaempferol results in increased secretion of CSF2 protein] CTD PMID:18346843 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP kaempferol promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CTNNB1 protein]] CTD PMID:29999212 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cycs cytochrome c, somatic multiple interactions
affects localization
ISO Caffeine inhibits the reaction [kaempferol affects the localization of CYCS protein] CTD PMID:19028473 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
increases activity
increases expression
ISO [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; kaempferol inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; kaempferol inhibits the reaction [Smoke results in increased expression of CYP1A1 mRNA]; kaempferol inhibits the reaction [Smoke results in increased expression of CYP1A1 protein]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; kaempferol promotes the reaction [Quercetin results in increased expression of CYP1A1 mRNA]
kaempferol inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; kaempferol inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
kaempferol results in decreased activity of CYP1A1 protein
kaempferol results in increased activity of CYP1A1 protein
kaempferol results in increased expression of CYP1A1 mRNA
CTD PMID:10359656, PMID:11454723, PMID:16271822, PMID:17012224, PMID:20846786, PMID:20930378, PMID:21053930, PMID:21256954, PMID:21329749, PMID:21482471, PMID:29584932 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
decreases activity
multiple interactions
ISO
EXP
kaempferol results in increased expression of CYP1A2 mRNA
kaempferol results in decreased activity of CYP1A2 protein
kaempferol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]
kaempferol results in increased expression of and results in increased activity of CYP1A2 protein
CTD PMID:18421621, PMID:19034627, PMID:20806393, PMID:21053930, PMID:21256954, PMID:29753067 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases expression
multiple interactions
decreases activity
ISO kaempferol results in decreased expression of CYP1B1 mRNA
kaempferol binds to and results in decreased activity of CYP1B1 protein; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1B1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1B1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]
kaempferol results in decreased activity of CYP1B1 protein
CTD PMID:16271822, PMID:19794518, PMID:20846786, PMID:21053930, PMID:21482471 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO kaempferol inhibits the reaction [propacetamol results in increased expression of CYP2E1 protein] CTD PMID:29574133 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Dhrs11 dehydrogenase/reductase 11 decreases activity ISO kaempferol results in decreased activity of DHRS11 protein CTD PMID:30926317 NCBI chr10:72,144,042...72,153,496
Ensembl chr10:72,144,042...72,153,375
JBrowse link
G Dio2 iodothyronine deiodinase 2 increases activity
increases expression
multiple interactions
ISO kaempferol results in increased activity of DIO2 protein
kaempferol results in increased expression of DIO2 mRNA
kaempferol promotes the reaction [DIO2 protein results in increased activity of and results in increased abundance of Triiodothyronine]
CTD PMID:17327447 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G Duox1 dual oxidase 1 multiple interactions ISO kaempferol inhibits the reaction [Paraquat results in increased expression of DUOX1 mRNA] CTD PMID:25177032 NCBI chr 3:114,251,794...114,286,827
Ensembl chr 3:114,253,637...114,286,802
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO kaempferol promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:20153296 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
affects binding
increases expression
increases activity
ISO
EXP
ESR1 protein inhibits the reaction [kaempferol results in increased expression of CCN5 mRNA]; ESR1 protein inhibits the reaction [kaempferol results in increased expression of PGR mRNA]; ESR1 protein inhibits the reaction [kaempferol results in increased expression of TFF1 mRNA]; Estradiol affects the reaction [kaempferol results in increased activity of ESR1 protein]; kaempferol binds to and results in increased activity of ESR1 protein; kaempferol inhibits the reaction [Estradiol binds to ESR1 protein]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 enhancer]]; kaempferol promotes the reaction [ESR1 protein binds to GREB1 enhancer]; kaempferol results in increased expression of and results in increased localization of ESR1 protein
kaempferol binds to ESR1 protein
kaempferol results in increased expression of ESR1 mRNA
CTD PMID:9751507, PMID:14579009, PMID:14706564, PMID:15182386, PMID:16118406, PMID:19913605, PMID:20846786, PMID:23384675, PMID:29162470 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
increases expression
affects binding
increases activity
ISO
EXP
Estradiol affects the reaction [kaempferol results in increased activity of ESR2 protein]; kaempferol binds to and results in increased activity of ESR2 protein; kaempferol inhibits the reaction [Estradiol binds to ESR2 protein]
kaempferol results in increased expression of ESR2 protein
ESR2 protein alternative form inhibits the reaction [kaempferol results in increased expression of ESR2 protein]
kaempferol binds to ESR2 protein
CTD PMID:9751507, PMID:12224631, PMID:14706564, PMID:15182386, PMID:16118406, PMID:18937077, PMID:19913605, PMID:27634370 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fbp1 fructose-bisphosphatase 1 decreases expression ISO kaempferol results in decreased expression of FBP1 mRNA CTD PMID:18331776 NCBI chr17:396,175...417,480
Ensembl chr17:396,180...417,480
JBrowse link
G Fn1 fibronectin 1 increases expression ISO kaempferol results in increased expression of FN1 protein CTD PMID:26408079 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO kaempferol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]
kaempferol inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]
CTD PMID:15322261, PMID:16434028 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta increases expression ISO kaempferol results in increased expression of GADD45B mRNA; kaempferol results in increased expression of GADD45B protein CTD PMID:18331776 NCBI chr 7:11,646,283...11,648,338
Ensembl chr 7:11,646,269...11,648,322
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO kaempferol results in increased expression of GCLC mRNA
kaempferol affects the reaction [propacetamol affects the expression of GCLC protein]
CTD PMID:11864778, PMID:29574133 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO kaempferol inhibits the reaction [Ethanol results in increased activity of GPT protein]; kaempferol inhibits the reaction [propacetamol results in increased activity of GPT protein] CTD PMID:29574133, PMID:31785310 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions
increases expression
ISO fulvestrant inhibits the reaction [kaempferol results in increased expression of GREB1 mRNA]; kaempferol promotes the reaction [ESR1 protein binds to GREB1 enhancer]; kaempferol promotes the reaction [NCOA3 protein binds to GREB1 enhancer] CTD PMID:20846786 NCBI chr 6:41,932,941...42,002,770
Ensembl chr 6:41,932,244...42,002,819
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 increases expression ISO kaempferol results in increased expression of GSTA1 mRNA CTD PMID:21256954 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gstm2 glutathione S-transferase mu 2 multiple interactions ISO [Quercetin co-treated with kaempferol] results in increased expression of GSTM2 mRNA CTD PMID:25111660 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity ISO kaempferol results in decreased activity of GSTP1 protein CTD PMID:15041478 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G H2ax H2A.X variant histone increases phosphorylation
increases expression
ISO kaempferol results in increased phosphorylation of H2AX protein
kaempferol results in increased expression of H2AX protein
CTD PMID:19028473, PMID:24595819 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hbb hemoglobin subunit beta multiple interactions ISO kaempferol inhibits the reaction [HBB gene polymorphism results in increased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] CTD PMID:14691983 NCBI chr 1:168,971,269...168,972,680
Ensembl chr 1:168,971,274...168,972,725
JBrowse link
G Hcar2 hydroxycarboxylic acid receptor 2 multiple interactions ISO kaempferol inhibits the reaction [Ethanol results in decreased expression of HCAR2 protein] CTD PMID:31785310 NCBI chr12:38,160,464...38,161,546
Ensembl chr12:38,160,464...38,161,546
JBrowse link
G Hgf hepatocyte growth factor multiple interactions ISO kaempferol inhibits the reaction [HGF protein results in increased phosphorylation of AKT1 protein]; kaempferol inhibits the reaction [HGF protein results in increased phosphorylation of MET protein] CTD PMID:19244381 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO kaempferol promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:20153296 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
Hemin promotes the reaction [kaempferol results in increased expression of HMOX1 protein]; HMOX1 protein promotes the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]; kaempferol affects the reaction [propacetamol affects the expression of HMOX1 protein]
[pterostilbene co-treated with kaempferol] results in increased expression of HMOX1 mRNA
kaempferol results in increased expression of HMOX1 mRNA; kaempferol results in increased expression of HMOX1 protein
CTD PMID:14563492, PMID:16303981, PMID:19265714, PMID:25111660, PMID:29574133 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of ICAM1 protein]; kaempferol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; kaempferol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:15322261, PMID:16987811, PMID:18394220 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma multiple interactions ISO kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of ICAM1 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of PTGS2 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of SELE protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of VCAM1 protein] CTD PMID:18394220 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO kaempferol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of ICAM1 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of PTGS2 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of SELE protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of VCAM1 protein]; kaempferol inhibits the reaction [IL1B protein results in increased expression of MUC5AC mRNA]; kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of MAP3K7 protein]; kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]; kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; kaempferol inhibits the reaction [IL1B protein results in increased ubiquitination of IRAK1 protein]; kaempferol inhibits the reaction [IL1B protein results in increased ubiquitination of TRAF6 protein]; kaempferol inhibits the reaction [IL32 protein results in increased expression of IL1B mRNA]; kaempferol inhibits the reaction [IL32 protein results in increased secretion of IL1B protein]; kaempferol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein]
CTD PMID:15985724, PMID:18394220, PMID:18946510, PMID:19367675, PMID:28711657, PMID:30769083 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il4 interleukin 4 multiple interactions ISO kaempferol inhibits the reaction [Calcimycin results in increased expression of IL4 mRNA] CTD PMID:12789233 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 multiple interactions ISO [Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in decreased expression of IL5 mRNA; kaempferol inhibits the reaction [Calcimycin results in increased expression of IL5 mRNA] CTD PMID:12789233, PMID:16797527 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in decreased expression of IL6 mRNA; kaempferol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 mRNA]
kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; kaempferol inhibits the reaction [propacetamol results in increased expression of IL6 protein]; kaempferol inhibits the reaction [TNF protein results in increased secretion of IL6 protein]
CTD PMID:16434028, PMID:16797527, PMID:20438634, PMID:28711657, PMID:29574133, PMID:30769083 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO kaempferol inhibits the reaction [IL1B protein results in increased ubiquitination of IRAK1 protein]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased ubiquitination of IRAK1 protein] CTD PMID:30769083 NCBI chr  X:156,716,469...156,726,367
Ensembl chr  X:156,716,604...156,725,977
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO kaempferol inhibits the reaction [IL32 protein results in increased expression of ITGAM mRNA]; kaempferol inhibits the reaction [IL32 protein results in increased expression of ITGAM protein] CTD PMID:28711657 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO kaempferol inhibits the reaction [Rotenone results in increased phosphorylation of JUN protein]; kaempferol inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; kaempferol inhibits the reaction [TNF protein results in increased expression of JUN mRNA] CTD PMID:15322261, PMID:20594614 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kmt2a lysine methyltransferase 2A increases mutagenesis ISO kaempferol results in increased mutagenesis of KMT2A gene CTD PMID:17468513 NCBI chr 8:49,110,407...49,185,872
Ensembl chr 8:49,114,990...49,158,971
JBrowse link
G Lamb2 laminin subunit beta 2 increases expression ISO kaempferol results in increased expression of LAMB2 protein CTD PMID:26408079 NCBI chr 8:117,268,335...117,280,517
Ensembl chr 8:117,268,337...117,280,517
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 multiple interactions ISO kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of MAP3K7 protein] CTD PMID:30769083 NCBI chr 5:47,183,142...47,244,424
Ensembl chr 5:47,186,558...47,244,416
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity
increases phosphorylation
multiple interactions
EXP
ISO
kaempferol results in increased activity of MAPK1 protein
kaempferol results in increased phosphorylation of MAPK1 protein
3',4'-dihydroxyflavone analog inhibits the reaction [kaempferol results in increased phosphorylation of MAPK1 protein]; kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; kaempferol inhibits the reaction [Paraquat results in increased phosphorylation of MAPK1 protein]
kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK1 protein modified form]; kaempferol inhibits the reaction [propacetamol results in increased phosphorylation of MAPK1 protein]
kaempferol inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK1 protein]
CTD PMID:15832817, PMID:16014620, PMID:18346843, PMID:19265714, PMID:19367675, PMID:22155320, PMID:25177032, PMID:29574133, PMID:30499162 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases activity
increases phosphorylation
multiple interactions
EXP
ISO
kaempferol results in increased activity of MAPK3 protein
kaempferol results in increased phosphorylation of MAPK3 protein
3',4'-dihydroxyflavone analog inhibits the reaction [kaempferol results in increased phosphorylation of MAPK3 protein]; kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]; kaempferol inhibits the reaction [Paraquat results in increased phosphorylation of MAPK3 protein]
kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK3 protein modified form]; kaempferol inhibits the reaction [propacetamol results in increased phosphorylation of MAPK3 protein]
kaempferol inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK3 protein]
CTD PMID:15832817, PMID:16014620, PMID:18346843, PMID:19265714, PMID:19367675, PMID:22155320, PMID:25177032, PMID:29574133, PMID:30499162 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO kaempferol results in increased phosphorylation of MAPK8 protein CTD PMID:30499162 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO kaempferol results in increased phosphorylation of MAPK9 protein CTD PMID:30499162 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase multiple interactions ISO kaempferol inhibits the reaction [HGF protein results in increased phosphorylation of MET protein] CTD PMID:19244381 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [kaempferol results in decreased expression of MMP2 protein]; kaempferol results in decreased expression of and results in decreased activity of MMP2 protein CTD PMID:26408079, PMID:30499162 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mt2A metallothionein 2A increases expression ISO kaempferol results in increased expression of MT2A mRNA CTD PMID:10656621 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO kaempferol inhibits the reaction [IL1B protein results in increased expression of MUC5AC mRNA]; kaempferol inhibits the reaction [Paraquat results in increased expression of MUC5AC mRNA] CTD PMID:19367675, PMID:25177032 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Nanog Nanog homeobox increases expression ISO kaempferol results in increased expression of NANOG protein CTD PMID:26683311 NCBI chr 4:155,531,906...155,539,268
Ensembl chr 4:155,531,906...155,539,268
JBrowse link
G Ncoa3 nuclear receptor coactivator 3 multiple interactions ISO kaempferol promotes the reaction [NCOA3 protein binds to GREB1 enhancer] CTD PMID:20846786 NCBI chr 3:162,692,176...162,788,582
Ensembl chr 3:162,692,185...162,787,548
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression
ISO [kaempferol co-treated with Quercetin] results in increased expression of NFE2L2 mRNA; kaempferol inhibits the reaction [Benzo(a)pyrene results in increased expression of NFE2L2 mRNA]
kaempferol affects the reaction [propacetamol affects the expression of NFE2L2 protein]
kaempferol results in increased expression of NFE2L2 mRNA
CTD PMID:21256954, PMID:25111660, PMID:29574133 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases phosphorylation
multiple interactions
ISO kaempferol results in decreased phosphorylation of NFKBIA protein
kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]
CTD PMID:17184768, PMID:20438634, PMID:30769083 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions
ISO kaempferol results in decreased expression of NOS2 mRNA; kaempferol results in decreased expression of NOS2 protein
Hemin promotes the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; HMOX1 protein promotes the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]; kaempferol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; PPARG protein affects the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; tin protoporphyrin IX inhibits the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]
kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]
CTD PMID:11343698, PMID:12512693, PMID:14563492, PMID:15832817, PMID:16934226, PMID:17177504, PMID:17184768, PMID:18274639, PMID:18394220, PMID:19352036, PMID:30769083, PMID:31306686 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO kaempferol inhibits the reaction [Paraquat results in increased expression of NOX4 mRNA] CTD PMID:25177032 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [pterostilbene co-treated with kaempferol] results in increased expression of NQO1 protein; [Quercetin co-treated with kaempferol] results in increased expression of NQO1 protein CTD PMID:25111660 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases expression
increases activity
ISO [kaempferol results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
kaempferol results in increased expression of NR1I2 mRNA
CTD PMID:19034627, PMID:25455453, PMID:26238175, PMID:29933105 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO kaempferol results in increased activity of NR1I3 protein CTD PMID:19034627 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Ocln occludin multiple interactions ISO kaempferol inhibits the reaction [Ethanol results in decreased expression of OCLN protein] CTD PMID:31785310 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
EXP
ISO
kaempferol inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]
kaempferol results in increased cleavage of PARP1 protein
3',4'-dihydroxyflavone analog inhibits the reaction [kaempferol results in increased cleavage of PARP1 protein]
CTD PMID:16014620, PMID:22155320 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP kaempferol promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein]] CTD PMID:29999212 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pgr progesterone receptor affects binding
increases expression
multiple interactions
ISO kaempferol binds to PGR protein
kaempferol results in increased expression of PGR mRNA
ESR1 protein inhibits the reaction [kaempferol results in increased expression of PGR mRNA]; kaempferol inhibits the reaction [Progesterone binds to PGR protein]
CTD PMID:14579009, PMID:23384675 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression
increases expression
ISO kaempferol results in decreased expression of POU5F1 protein
kaempferol results in increased expression of POU5F1 protein
CTD PMID:22906706, PMID:26683311 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression
ISO kaempferol binds to and results in increased activity of PPARG protein; kaempferol inhibits the reaction [Rosiglitazone binds to and results in increased activity of PPARG protein]; PPARG protein affects the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; PPARG protein affects the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]
kaempferol results in increased expression of PPARG mRNA; kaempferol results in increased expression of PPARG protein
CTD PMID:11343698, PMID:18262572, PMID:25765892 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO kaempferol results in increased expression of PPARGC1A mRNA CTD PMID:17327447 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Psca prostate stem cell antigen decreases expression ISO kaempferol results in decreased expression of PSCA mRNA CTD PMID:18331776 NCBI chr 7:116,090,189...116,091,955
Ensembl chr 7:116,090,189...116,091,955
JBrowse link
G Ptges prostaglandin E synthase multiple interactions ISO kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGES mRNA] CTD PMID:21341175 NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
ISO kaempferol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; PPARG protein affects the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]
kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of PTGS2 protein]; kaempferol inhibits the reaction [TGFA protein results in increased expression of PTGS2 mRNA]
kaempferol results in decreased expression of PTGS2 mRNA; kaempferol results in decreased expression of PTGS2 protein
CTD PMID:10783318, PMID:11343698, PMID:17184768, PMID:18394220, PMID:19352036, PMID:21341175, PMID:30769083, PMID:31306686 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO kaempferol inhibits the reaction [Uric Acid promotes the reaction [PYCARD protein binds to PYCARD protein]] CTD PMID:29960001 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO kaempferol inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein]; kaempferol inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; kaempferol inhibits the reaction [TNF protein results in increased localization of RELA protein]
kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RELA protein]
CTD PMID:16434028, PMID:18274639, PMID:20438634, PMID:30769083 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions ISO kaempferol inhibits the reaction [propacetamol results in increased expression of RIPK1 protein] CTD PMID:29574133 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
G Rpa3 replication protein A3 multiple interactions ISO [Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in increased expression of RPA3 mRNA CTD PMID:16797527 NCBI chr 4:34,279,320...34,282,351
Ensembl chr 4:34,279,320...34,282,351
JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression ISO kaempferol results in increased expression of RUNX2 mRNA CTD PMID:23989061 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Sele selectin E multiple interactions ISO kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of SELE protein]; kaempferol inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:16987811, PMID:18394220 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Sfn stratifin increases expression ISO kaempferol results in increased expression of SFN mRNA; kaempferol results in increased expression of SFN protein CTD PMID:18331776 NCBI chr 5:151,823,422...151,824,937
Ensembl chr 5:151,823,887...151,824,633
JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions EXP
ISO
[kaempferol results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate
kaempferol inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid]
CTD PMID:17108059, PMID:25719685 NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554
JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases activity
decreases expression
multiple interactions
ISO kaempferol results in decreased activity of SLC2A1 protein
kaempferol results in decreased expression of SLC2A1 mRNA
kaempferol inhibits the reaction [SLC2A1 protein affects the transport of Glucose]
CTD PMID:14642735, PMID:25719685 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO kaempferol inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein] CTD PMID:18591783 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Slc5a8 solute carrier family 5 member 8 multiple interactions ISO kaempferol inhibits the reaction [Ethanol results in decreased expression of SLC5A8 protein] CTD PMID:31785310 NCBI chr 7:29,434,175...29,476,807
Ensembl chr 7:29,435,444...29,477,947
JBrowse link
G Slco1a1 solute carrier organic anion transporter family, member 1a1 decreases activity
multiple interactions
EXP kaempferol results in decreased activity of SLCO1B1 protein
[kaempferol results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [kaempferol results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Methotrexate
CTD PMID:32259555 NCBI chr 4:176,158,174...176,231,331
Ensembl chr 4:176,158,640...176,231,344
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO kaempferol inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein] CTD PMID:22394605 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression
ISO [pterostilbene co-treated with kaempferol] results in increased expression of SOD1 protein; [Quercetin co-treated with kaempferol] results in increased expression of SOD1 protein
kaempferol results in increased expression of SOD1 protein
CTD PMID:25111660 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
affects response to substance
increases expression
ISO fulvestrant inhibits the reaction [kaempferol results in increased expression of SOD2 protein]
SOD2 protein affects the susceptibility to kaempferol
CTD PMID:23526725 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sox9 SRY-box transcription factor 9 increases expression ISO kaempferol results in increased expression of SOX9 mRNA CTD PMID:23989061 NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO kaempferol inhibits the reaction [APOE affects the expression of SPP1 mRNA]; kaempferol inhibits the reaction [APOE affects the expression of SPP1 protein] CTD PMID:22005275 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO kaempferol inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of STAT1 protein alternative form] CTD PMID:18274639 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat2 signal transducer and activator of transcription 2 multiple interactions ISO [Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in decreased expression of STAT2 mRNA CTD PMID:16797527 NCBI chr 7:2,691,064...2,707,530
Ensembl chr 7:2,691,369...2,707,741
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO kaempferol results in increased expression of TFAM mRNA CTD PMID:17327447 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151
JBrowse link
G Tff1 trefoil factor 1 increases expression
multiple interactions
ISO kaempferol results in increased expression of TFF1 mRNA
ESR1 protein inhibits the reaction [kaempferol results in increased expression of TFF1 mRNA]
CTD PMID:14706564, PMID:23384675 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO kaempferol inhibits the reaction [TGFA protein results in increased expression of PTGS2 mRNA] CTD PMID:10783318 NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO kaempferol inhibits the reaction [Ethanol results in decreased expression of TJP1 protein] CTD PMID:31785310 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases activity
ISO kaempferol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; kaempferol inhibits the reaction [propacetamol results in increased expression of TNF protein]; kaempferol inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; kaempferol inhibits the reaction [TNF protein results in increased localization of RELA protein]; kaempferol inhibits the reaction [TNF protein results in increased secretion of CCL2 protein]; kaempferol inhibits the reaction [TNF protein results in increased secretion of IL6 protein]
kaempferol results in decreased activity of TNF protein
kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of ICAM1 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of PTGS2 protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of SELE protein]; kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of VCAM1 protein]; kaempferol inhibits the reaction [IL32 protein results in increased expression of TNF mRNA]; kaempferol inhibits the reaction [IL32 protein results in increased secretion of TNF protein]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; kaempferol inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; kaempferol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; kaempferol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; kaempferol inhibits the reaction [TNF protein results in increased expression of JUN mRNA]; kaempferol inhibits the reaction [TNF protein results in increased expression of SELE protein]
CTD PMID:15322261, PMID:15985724, PMID:16434028, PMID:16934226, PMID:16987811, PMID:18394220, PMID:20438634, PMID:28711657, PMID:29574133, PMID:30769083, PMID:31306686 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 multiple interactions ISO kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA] CTD PMID:20438634 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807
JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A multiple interactions ISO kaempferol inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A mRNA] CTD PMID:16434028 NCBI chr13:25,778,306...25,835,802
Ensembl chr13:25,778,317...25,835,957
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO kaempferol inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA]; kaempferol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; kaempferol inhibits the reaction [TNFSF11 protein results in increased expression of TNFRSF11A mRNA] CTD PMID:16434028 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Tp53 tumor protein p53 multiple interactions
affects response to substance
increases phosphorylation
increases expression
ISO
EXP
Caffeine inhibits the reaction [kaempferol results in increased phosphorylation of TP53 protein]; TP53 protein affects the reaction [kaempferol promotes the reaction [BBC3 protein binds to BCL2L1 protein]]
kaempferol inhibits the reaction [Doxorubicin promotes the reaction [TP53 protein binds to BAX promoter]]; kaempferol inhibits the reaction [Doxorubicin results in increased expression of TP53 mRNA]
TP53 protein affects the susceptibility to kaempferol
kaempferol results in increased expression of TP53 protein
CTD PMID:19028473, PMID:22155320 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp53i3 tumor protein p53 inducible protein 3 increases expression ISO kaempferol results in increased expression of TP53I3 mRNA; kaempferol results in increased expression of TP53I3 protein CTD PMID:18331776, PMID:19397994 NCBI chr13:75,101,759...75,145,967
Ensembl chr13:75,105,615...75,143,441
JBrowse link
G Tp63 tumor protein p63 increases expression ISO kaempferol results in increased expression of TP63 protein CTD PMID:18331776, PMID:19397994 NCBI chr11:78,234,853...78,456,559
Ensembl chr11:78,234,800...78,456,501
JBrowse link
G Tp73 tumor protein p73 increases expression ISO kaempferol results in increased expression of TP73 protein CTD PMID:18331776, PMID:19397994 NCBI chr 5:171,355,876...171,415,354
Ensembl chr 5:171,355,876...171,415,354
JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO kaempferol inhibits the reaction [IL1B protein results in increased ubiquitination of TRAF6 protein] CTD PMID:30769083 NCBI chr 3:91,252,829...91,271,607
Ensembl chr 3:91,252,829...91,271,607
JBrowse link
G Tslp thymic stromal lymphopoietin multiple interactions ISO kaempferol inhibits the reaction [IL32 protein results in increased expression of TSLP mRNA]; kaempferol inhibits the reaction [IL32 protein results in increased secretion of TSLP protein]; kaempferol inhibits the reaction [Lipopolysaccharides results in increased secretion of TSLP protein] CTD PMID:28711657 NCBI chr18:25,613,601...25,618,066
Ensembl chr18:25,613,831...25,617,361
JBrowse link
G Tubb3 tubulin, beta 3 class III decreases expression ISO kaempferol results in decreased expression of TUBB3 protein CTD PMID:26683311 NCBI chr19:56,220,759...56,229,813
Ensembl chr19:56,220,755...56,229,813
JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions EXP kaempferol inhibits the reaction [Dietary Fats results in decreased expression of UCP1 mRNA] CTD PMID:30372826 NCBI chr19:24,456,976...24,464,808
Ensembl chr19:24,456,976...24,464,807
JBrowse link
G Ucp3 uncoupling protein 3 increases expression ISO kaempferol results in increased expression of UCP3 mRNA CTD PMID:17327447 NCBI chr 1:165,482,912...165,495,895
Ensembl chr 1:165,482,155...165,496,206
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation
multiple interactions
ISO UGT1A1 protein results in increased glucuronidation of kaempferol
kaempferol inhibits the reaction [propacetamol results in decreased expression of UGT1A1 protein]
CTD PMID:14557274, PMID:29574133 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation
affects glucuronidation
ISO UGT1A3 protein results in increased glucuronidation of kaempferol
UGT1A3 mutant form affects the glucuronidation of kaempferol
CTD PMID:16738032 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of kaempferol CTD PMID:14557274 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of kaempferol CTD PMID:14557274 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Utrn utrophin increases expression ISO kaempferol results in increased expression of UTRN mRNA CTD PMID:22028826 NCBI chr 1:6,451,809...6,970,040
Ensembl chr 1:6,451,810...6,970,040
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO kaempferol inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of VCAM1 protein] CTD PMID:18394220 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vdr vitamin D receptor increases activity ISO kaempferol results in increased activity of VDR protein CTD PMID:26366751 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA] CTD PMID:20438634 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
afzelin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mitf melanocyte inducing transcription factor increases expression ISO afzelin results in increased expression of MITF mRNA; afzelin results in increased expression of MITF protein CTD PMID:27287415 NCBI chr 4:130,172,484...130,425,496
Ensembl chr 4:130,172,727...130,425,532
JBrowse link
G Tyr tyrosinase multiple interactions
increases expression
ISO afzelin results in increased expression of and results in increased activity of TYR protein
afzelin results in increased expression of TYR mRNA
CTD PMID:27287415 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link
G Tyrp1 tyrosinase-related protein 1 increases expression ISO afzelin results in increased expression of TYRP1 mRNA; afzelin results in increased expression of TYRP1 protein CTD PMID:27287415 NCBI chr 5:98,387,291...98,406,083
Ensembl chr 5:98,387,291...98,406,083
JBrowse link
herbacetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fasn fatty acid synthase multiple interactions ISO herbacetin inhibits the reaction [Dietary Fats results in increased activity of FASN protein] CTD PMID:29653099 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions ISO herbacetin inhibits the reaction [Dietary Fats results in increased activity of G6PD protein] CTD PMID:29653099 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO herbacetin inhibits the reaction [Dietary Fats results in increased activity of GPT protein] CTD PMID:29653099 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO herbacetin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA] CTD PMID:29653099 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO herbacetin inhibits the reaction [Dietary Fats results in increased expression of SREBF2 mRNA] CTD PMID:29653099 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603
JBrowse link
kaempferide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc2a1 solute carrier family 2 member 1 decreases expression ISO kaempferide results in decreased expression of SLC2A1 mRNA CTD PMID:21865046 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO kaempferide results in increased expression of VEGFA mRNA CTD PMID:21865046 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
kaempferol 3-O-beta-D-galactoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pla2g2a phospholipase A2 group IIA affects activity ISO kaempferol-3-O-galactoside affects the activity of PLA2G2A protein CTD PMID:8190018 NCBI chr 5:157,282,650...157,285,295
Ensembl chr 5:157,282,669...157,285,328
JBrowse link
kaempferol 3-O-beta-D-glucoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA] CTD PMID:22210036 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 mRNA] CTD PMID:22210036 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] CTD PMID:22210036 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:22210036 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO astragalin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein] CTD PMID:22210036 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:22210036 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:22210036 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO astragalin inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein] CTD PMID:22210036 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO astragalin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:22210036 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
robinin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 affects activity ISO robinin affects the activity of ABCC1 protein CTD PMID:15796199 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        antimicrobial agent 17309
          antibacterial agent 13019
            kaempferol 167
              (+)-dihydrokaempferol + 0
              3,4'-dimethylkaempferol 0
              4',5,7-trihydroxy-3-methoxyflavone-7-O-beta-D-glucopyranoside 0
              4',5,7-trihydroxy-3-methoxyflavone-7-O-rutinoside 0
              563476_TEMP_6-hydroxykaempferol 0
              6''-O-acetylgenistin 0
              6''-malonylastragalin 0
              6-hydroxykaempferol 0
              7,4'-dimethylkaempferol 0
              8-lavandulylkaempferol 0
              afzelin 3
              cudranian 1 0
              herbacetin 5
              hermannioside B 0
              kaempferide + 2
              kaempferol 3,7-di-O-alpha-L-rhamnoside 0
              kaempferol 3-O-(5-O-acetyl-alpha-D-apiofuranosyl)-7-O-alpha-L-rhamnopyranoside 0
              kaempferol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] 0
              kaempferol 3-O-[alpha-L-rhamnopyranosyl(1->2)-beta-D-galactopyranosyl]-7-O-alpha-L-rhamnopyranoside 0
              kaempferol 3-O-alpha-L-arabinopyranosyl-7-O-alpha-L-rhamnopyranoside 0
              kaempferol 3-O-beta-D-allopyranoside 0
              kaempferol 3-O-beta-D-apiofuranosyl-7-O-alpha-L-rhamnopyranoside 0
              kaempferol 3-O-beta-D-galactopyranosyl-7-O-alpha-L-rhamnopyranoside 0
              kaempferol 3-O-beta-D-galactoside 1
              kaempferol 3-O-beta-D-glucosylgalactoside 0
              kaempferol 3-O-beta-D-xyloside 0
              kaempferol 3-O-gentiobioside-7-O-rhamnoside 0
              kaempferol 7-O-beta-D-galactopyranoside 0
              kaempferol O-glucoside + 9
              kaempferol O-glucuronide + 0
              multiflorin B 0
              rhamnocitrin 0
              robinin 1
              sexangularetin 0
              tribuloside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  oxacycle 17181
                                    benzopyran 10132
                                      1-benzopyran 9848
                                        flavonoid 6372
                                          flavones 4166
                                            hydroxyflavone 4154
                                              flavonols 4070
                                                7-hydroxyflavonol 4049
                                                  kaempferol 167
                                                    (+)-dihydrokaempferol + 0
                                                    3,4'-dimethylkaempferol 0
                                                    4',5,7-trihydroxy-3-methoxyflavone-7-O-beta-D-glucopyranoside 0
                                                    4',5,7-trihydroxy-3-methoxyflavone-7-O-rutinoside 0
                                                    563476_TEMP_6-hydroxykaempferol 0
                                                    6''-O-acetylgenistin 0
                                                    6''-malonylastragalin 0
                                                    6-hydroxykaempferol 0
                                                    7,4'-dimethylkaempferol 0
                                                    8-lavandulylkaempferol 0
                                                    afzelin 3
                                                    cudranian 1 0
                                                    herbacetin 5
                                                    hermannioside B 0
                                                    kaempferide + 2
                                                    kaempferol 3,7-di-O-alpha-L-rhamnoside 0
                                                    kaempferol 3-O-(5-O-acetyl-alpha-D-apiofuranosyl)-7-O-alpha-L-rhamnopyranoside 0
                                                    kaempferol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] 0
                                                    kaempferol 3-O-[alpha-L-rhamnopyranosyl(1->2)-beta-D-galactopyranosyl]-7-O-alpha-L-rhamnopyranoside 0
                                                    kaempferol 3-O-alpha-L-arabinopyranosyl-7-O-alpha-L-rhamnopyranoside 0
                                                    kaempferol 3-O-beta-D-allopyranoside 0
                                                    kaempferol 3-O-beta-D-apiofuranosyl-7-O-alpha-L-rhamnopyranoside 0
                                                    kaempferol 3-O-beta-D-galactopyranosyl-7-O-alpha-L-rhamnopyranoside 0
                                                    kaempferol 3-O-beta-D-galactoside 1
                                                    kaempferol 3-O-beta-D-glucosylgalactoside 0
                                                    kaempferol 3-O-beta-D-xyloside 0
                                                    kaempferol 3-O-gentiobioside-7-O-rhamnoside 0
                                                    kaempferol 7-O-beta-D-galactopyranoside 0
                                                    kaempferol O-glucoside + 9
                                                    kaempferol O-glucuronide + 0
                                                    multiflorin B 0
                                                    rhamnocitrin 0
                                                    robinin 1
                                                    sexangularetin 0
                                                    tribuloside 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.