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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:acadesine
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Accession:CHEBI:28498 term browser browse the term
Definition:A 1-ribosylimidazolecarboxamide in which the carboxamide group is situated at position 4 of the imidazole ring, which is further substituted at position 5 by an amino group. A purine nucleoside analogue and activator of AMP-activated protein kinase, it is is used for the treatment of acute lymphoblastic leukemia and is reported to have cardioprotective effects.
Synonyms:exact_synonym: 5-amino-1-(beta-D-ribofuranosyl)-1H-imidazole-4-carboxamide
 related_synonym: 5-amino-1-beta-D-ribofuranosyl-4-imidazolecarboxamide;   5-amino-1-beta-D-ribofuranosylimidazole-4-carboxamide;   5-amino-1-beta-ribofuranosyl-imidazole-4-carboxamide;   5-amino-1-ribofuranosylimidazole-4-carboxamide;   5-amino-1beta-D-ribofuranosylimidazole-4-carboxyamide;   5-amino-4-imidazolecarboxamide ribofuranoside;   5-aminoimidazole-4-carboxamide ribonucleoside;   AIC-Riboside;   AICA-riboside;   AICAr;   EC Number 220-097-5;   Formula=C9H14N4O5;   GP 1-110;   InChI=1S/C9H14N4O5/c10-7-4(8(11)17)12-2-13(7)9-6(16)5(15)3(1-14)18-9/h2-3,5-6,9,14-16H,1,10H2,(H2,11,17)/t3-,5-,6-,9-/m1/s1;   InChIKey=RTRQQBHATOEIAF-UUOKFMHZSA-N;   N(1)-(beta-D-ribofuranosyl)-5-aminoimidazole-4-carboxamide;   SMILES=NC(=O)c1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c1N;   acadesina;   acadesinum
 alt_id: CHEBI:2025;   CHEBI:20539
 xref: CAS:2627-69-2;   DrugBank:DB04944;   Drug_Central:37;   KEGG:D02742
 xref_mesh: MESH:C011651
 xref: PMID:17513706;   PMID:17706943;   PMID:18090925;   PMID:18457469;   PMID:18671468;   PMID:20185792;   PMID:20367195;   PMID:21244913;   PMID:23228986;   PMID:24303202;   PMID:24519895;   PMID:24778186;   PMID:8227467;   PMID:8458030;   Reaxys:38255;   Wikipedia:Acadesine



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acadesine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression
multiple interactions
EXP
ISO
acadesine decreases expression of Abcb11 mRNA in primary hepatocytes
acadesine inhibits the reaction [picroside II inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCB11 mRNA]]; acadesine inhibits the reaction [picroside II inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCB11 protein]]
CTD
RGD
PMID:32976922 PMID:27090119 RGD:15090804 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression EXP acadesine decreases expression of Abcc2 mRNA in primary hepatocytes RGD PMID:27090119 RGD:15090804 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases phosphorylation EXP acadesine results in increased phosphorylation of ACACA protein CTD PMID:22496244 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Acads acyl-CoA dehydrogenase short chain multiple interactions EXP acadesine inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of ACADS mRNA]; acadesine inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of and results in decreased activity of ACADS protein] CTD PMID:26989860 NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898
JBrowse link
G Agrp agouti related neuropeptide increases expression ISO acadesine results in increased expression of AGRP mRNA CTD PMID:32575098 NCBI chr19:33,447,992...33,481,602
Ensembl chr19:33,447,992...33,449,584
JBrowse link
G Agt angiotensinogen multiple interactions EXP acadesine inhibits the reaction [AGT protein results in decreased expression of GJA1 protein]; acadesine inhibits the reaction [AGT protein results in decreased expression of GJA5 protein]; dorsomorphin inhibits the reaction [acadesine inhibits the reaction [AGT protein results in decreased expression of GJA1 protein]] CTD PMID:33676887 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
decreases phosphorylation
ISO acadesine results in increased phosphorylation of AKT1 protein
acadesine results in decreased phosphorylation of AKT1 protein
CTD PMID:22137261 PMID:25603053 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Apln apelin multiple interactions ISO acadesine inhibits the reaction [Thioctic Acid results in increased expression of APLN mRNA]; acadesine inhibits the reaction [Thioctic Acid results in increased secretion of APLN protein] CTD PMID:21461750 NCBI chr  X:127,180,801...127,213,567
Ensembl chr  X:127,203,823...127,213,391
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP acadesine inhibits the reaction [tert-Butylhydroperoxide results in increased expression of BAX protein] CTD PMID:26989860 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO
acadesine inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]
acadesine promotes the reaction [Artesunate results in decreased expression of BCL2 protein]
CTD PMID:26989860 PMID:33002460 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Becn1 beclin 1 multiple interactions ISO acadesine promotes the reaction [Zearalenone results in increased expression of BECN1 protein] CTD PMID:31982503 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO
EXP
acadesine promotes the reaction [Isoniazid results in increased cleavage of CASP3 protein]
acadesine results in increased cleavage of CASP3 protein
acadesine inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of CASP3 protein]
CTD PMID:22137261 PMID:25603053 PMID:26989860 PMID:28556920 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases cleavage ISO acadesine results in increased cleavage of CASP9 protein CTD PMID:22137261 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO acadesine promotes the reaction [Capsaicin results in increased expression of CDH1 protein] CTD PMID:36044967 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO acadesine promotes the reaction [Capsaicin results in decreased expression of CDH2 protein] CTD PMID:36044967 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cldn2 claudin 2 multiple interactions
decreases expression
ISO acadesine promotes the reaction [solasodine results in decreased expression of CLDN2 protein]
acadesine results in decreased expression of CLDN2 protein
CTD PMID:37121296 NCBI chr  X:103,459,870...103,473,794
Ensembl chr  X:103,459,780...103,474,838
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP acadesine inhibits the reaction [Acrylamide results in increased expression of CYP2E1 protein]; acadesine inhibits the reaction [glycidamide results in increased expression of CYP2E1 protein] CTD PMID:33545342 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 multiple interactions ISO acadesine promotes the reaction [picroside II promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP8B1 mRNA]]; acadesine promotes the reaction [picroside II promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP8B1 protein]] CTD PMID:32976922 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
JBrowse link
G Ednra endothelin receptor type A multiple interactions EXP acadesine inhibits the reaction [Smoke results in increased expression of EDNRA protein] CTD PMID:36183783 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP acadesine inhibits the reaction [Smoke results in increased expression of EDNRB protein] CTD PMID:36183783 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO acadesine inhibits the reaction [Dibutyl Phthalate results in increased expression of FASN protein] CTD PMID:33508418 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fndc5 fibronectin type III domain containing 5 multiple interactions ISO acadesine inhibits the reaction [Palmitates results in decreased expression of FNDC5 mRNA]; acadesine inhibits the reaction [Palmitates results in decreased expression of FNDC5 protein] CTD PMID:36375515 NCBI chr 5:141,481,593...141,491,257
Ensembl chr 5:141,481,590...141,490,731
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP acadesine inhibits the reaction [AGT protein results in decreased expression of GJA1 protein]; dorsomorphin inhibits the reaction [acadesine inhibits the reaction [AGT protein results in decreased expression of GJA1 protein]] CTD PMID:33676887 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gja5 gap junction protein, alpha 5 multiple interactions EXP acadesine inhibits the reaction [AGT protein results in decreased expression of GJA5 protein] CTD PMID:33676887 NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952
JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial multiple interactions ISO acadesine inhibits the reaction [[Oleic Acid co-treated with Dibutyl Phthalate] results in increased expression of GPAM protein]; acadesine inhibits the reaction [Dibutyl Phthalate results in increased expression of GPAM protein] CTD PMID:33508418 NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha multiple interactions ISO acadesine promotes the reaction [Capsaicin affects the localization of MAP1LC3A protein] CTD PMID:36044967 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO acadesine promotes the reaction [Artesunate results in increased lipidation of MAP1LC3B protein] CTD PMID:33002460 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP acadesine inhibits the reaction [Acrylamide results in increased phosphorylation of MAPK1 protein]; acadesine inhibits the reaction [glycidamide results in increased phosphorylation of MAPK1 protein] CTD PMID:33545342 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP acadesine inhibits the reaction [Acrylamide results in increased phosphorylation of MAPK3 protein]; acadesine inhibits the reaction [glycidamide results in increased phosphorylation of MAPK3 protein] CTD PMID:33545342 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mef2c myocyte enhancer factor 2C decreases expression ISO acadesine results in decreased expression of MEF2C mRNA CTD PMID:15864539 NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO acadesine promotes the reaction [Zearalenone results in decreased phosphorylation of MTOR protein]
acadesine promotes the reaction [Artesunate results in decreased phosphorylation of MTOR protein]; acadesine promotes the reaction [Capsaicin results in decreased phosphorylation of MTOR protein]
CTD PMID:31982503 PMID:33002460 PMID:36044967 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression
multiple interactions
EXP
ISO
acadesine decreases expression of Nr1h4 mRNA and protein in primary hepatocytes
acadesine inhibits the reaction [picroside II inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR1H4 mRNA]]; acadesine inhibits the reaction [picroside II inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR1H4 protein]]
CTD
RGD
PMID:32976922 PMID:27090119 RGD:15090804 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions
increases expression
ISO acadesine inhibits the reaction [Isoniazid results in decreased expression of NRF1 protein]
acadesine results in increased expression of NRF1 protein
CTD PMID:28556920 NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328
JBrowse link
G Ocln occludin multiple interactions ISO acadesine promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of OCLN protein] CTD PMID:33400020 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO acadesine promotes the reaction [Artesunate results in increased cleavage of PARP1 protein] CTD PMID:33002460 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP acadesine inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of PPARA mRNA]; acadesine inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of PPARA protein] CTD PMID:26989860 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions
increases expression
ISO
EXP
acadesine inhibits the reaction [Isoniazid results in decreased expression of PPARGC1A protein]
acadesine results in increased expression of PPARGC1A protein
Dietary Fats promotes the reaction [acadesine results in increased expression of PPARGC1A mRNA]
CTD PMID:22496244 PMID:28556920 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases phosphorylation
multiple interactions
EXP
ISO
acadesine increases phosphorylation of Prkaa1 in primary hepatocytes
acadesine results in increased phosphorylation of PRKAA1 protein
acadesine promotes the reaction [Capsaicin results in increased expression of PRKAA1 protein]
acadesine inhibits the reaction [Smoke results in decreased phosphorylation of PRKAA1 protein]
CTD
RGD
PMID:22815988 PMID:33676887 PMID:36044967 PMID:36183783 PMID:37121296 More... RGD:15090804 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions ISO acadesine promotes the reaction [Capsaicin results in increased expression of PRKAA2 protein] CTD PMID:36044967 NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO acadesine inhibits the reaction [[Fluorouracil results in increased expression of PTGS2 protein] which results in increased abundance of and results in increased secretion of Dinoprostone]; acadesine inhibits the reaction [Fluorouracil results in increased expression of PTGS2 protein] CTD PMID:15896711 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rhoa ras homolog family member A decreases expression ISO acadesine results in decreased expression of RHOA protein CTD PMID:37121296 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO acadesine promotes the reaction [Zearalenone results in decreased phosphorylation of RPS6KB1 protein] CTD PMID:31982503 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Sirt1 sirtuin 1 multiple interactions
increases expression
ISO acadesine inhibits the reaction [Isoniazid results in decreased expression of SIRT1 protein]
acadesine results in increased expression of SIRT1 protein
CTD PMID:28556920 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression EXP acadesine decreases expression of Slc10a1 mRNA in primary hepatocytes RGD PMID:27090119 RGD:15090804 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression ISO acadesine results in increased expression of SLC2A1 mRNA CTD PMID:15864539 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 decreases expression EXP acadesine decreases expression of Slco1a4 mRNA in primary hepatocytes RGD PMID:27090119 RGD:15090804 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO acadesine inhibits the reaction [Dibutyl Phthalate results in increased expression of SREBF1 protein] CTD PMID:33508418 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO acadesine inhibits the reaction [SEW2871 inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of TJP1 protein]]; acadesine promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of TJP1 protein] CTD PMID:33400020 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 multiple interactions ISO acadesine promotes the reaction [Artesunate results in increased phosphorylation of ULK1 protein] CTD PMID:33002460 NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966
JBrowse link
G Zfp57 zinc finger protein 57 multiple interactions ISO acadesine inhibits the reaction [Palmitates results in increased expression of ZFP57 mRNA]; acadesine inhibits the reaction [Palmitates results in increased expression of ZFP57 protein] CTD PMID:36375515 NCBI chr20:1,521,323...1,534,884
Ensembl chr20:1,521,323...1,529,846
JBrowse link
AICA ribonucleotide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression EXP AICA ribonucleotide results in decreased expression of ABCB11 mRNA CTD PMID:27090119 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression EXP AICA ribonucleotide results in decreased expression of ABCC2 mRNA CTD PMID:27090119 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions ISO AICA ribonucleotide promotes the reaction [ABL1 protein mutant form binds to BECN1 protein]; AICA ribonucleotide promotes the reaction [ABL1 protein mutant form binds to XPO1 protein]; AICA ribonucleotide promotes the reaction [ABL1 protein mutant form binds to YWHAQ protein]; AICA ribonucleotide results in decreased expression of and affects the localization of ABL1 protein mutant form CTD PMID:33070465 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065
JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases phosphorylation
multiple interactions
increases expression
ISO
EXP
AICA ribonucleotide results in increased phosphorylation of ACACA protein
AICA ribonucleotide inhibits the reaction [fipronil results in increased expression of and results in decreased phosphorylation of ACACA protein]; AICA ribonucleotide results in decreased expression of and results in increased phosphorylation of ACACA protein
AICA ribonucleotide results in increased expression of ACACA protein modified form
CTD PMID:15297373 PMID:16020477 PMID:16873680 PMID:20080969 PMID:25743752 More... NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Acacb acetyl-CoA carboxylase beta increases phosphorylation ISO AICA ribonucleotide results in increased phosphorylation of ACACB protein CTD PMID:16873680 NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain multiple interactions
increases expression
EXP
ISO
AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of ACADM mRNA]
AICA ribonucleotide results in increased expression of ACADM mRNA; AICA ribonucleotide results in increased expression of ACADM protein
CTD PMID:19699196 PMID:25743752 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO AICA ribonucleotide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:27688165 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression
multiple interactions
ISO
EXP
AICA ribonucleotide results in increased expression of ADIPOQ protein
AICA ribonucleotide inhibits the reaction [Palmitic Acid results in decreased expression of ADIPOQ mRNA]
CTD PMID:20980258 PMID:25108154 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO AICA ribonucleotide inhibits the reaction [AKT1 protein mutant form results in decreased oxidation of Fatty Acids]; AICA ribonucleotide inhibits the reaction [AKT1 protein mutant form results in increased phosphorylation of EIF4EBP1 protein]; AICA ribonucleotide inhibits the reaction [AKT1 protein mutant form results in increased susceptibility to Glucose deficiency]; PRKAA2 protein affects the reaction [AICA ribonucleotide inhibits the reaction [AKT1 protein mutant form affects the susceptibility to Glucose deficiency]] CTD PMID:15806154 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G App amyloid beta precursor protein decreases expression ISO AICA ribonucleotide results in decreased expression of APP protein modified form CTD PMID:20080969 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Arg1 arginase 1 multiple interactions EXP AICA ribonucleotide inhibits the reaction [Palmitic Acid results in decreased expression of ARG1 mRNA] CTD PMID:25108154 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Atg5 autophagy related 5 multiple interactions ISO AICA ribonucleotide inhibits the reaction [Ethanol results in decreased expression of ATG5 protein] CTD PMID:24582693 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Becn1 beclin 1 increases expression
multiple interactions
EXP
ISO
AICA ribonucleotide results in increased expression of BECN1 protein
AICA ribonucleotide promotes the reaction [ABL1 protein mutant form binds to BECN1 protein]; AICA ribonucleotide promotes the reaction [XPO1 protein binds to BECN1 protein]; AICA ribonucleotide results in increased expression of and affects the localization of BECN1 protein
AICA ribonucleotide promotes the reaction [4-nonylphenol results in increased expression of BECN1 protein]
CTD PMID:28041982 PMID:33070465 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
EXP
ISO
AICA ribonucleotide results in increased activity of CASP3 protein
AICA ribonucleotide inhibits the reaction [sunitinib results in increased cleavage of CASP3 protein]
CTD PMID:16469385 PMID:21906609 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 multiple interactions ISO AICA ribonucleotide inhibits the reaction [sunitinib results in increased cleavage of CASP7 protein] CTD PMID:21906609 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp9 caspase 9 increases activity EXP AICA ribonucleotide results in increased activity of CASP9 protein CTD PMID:16469385 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions
increases expression
ISO AICA ribonucleotide promotes the reaction [FOXO1 protein results in increased expression of CAT mRNA]
AICA ribonucleotide results in increased expression of CAT mRNA; AICA ribonucleotide results in increased expression of CAT protein
CTD PMID:25065674 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
EXP
ISO
AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased expression of CCL2 mRNA]
AICA ribonucleotide results in decreased expression of CCL2 mRNA
AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; dorsomorphin inhibits the reaction [AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]]; dorsomorphin inhibits the reaction [AICA ribonucleotide results in decreased expression of CCL2 mRNA]
CTD PMID:24465016 PMID:25108154 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased expression of CCL3 mRNA] CTD PMID:21745629 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccna2 cyclin A2 multiple interactions
decreases expression
ISO AICA ribonucleotide inhibits the reaction [ELAVL1 protein binds to CCNA2 3' UTR]
AICA ribonucleotide results in decreased expression of CCNA2 mRNA; AICA ribonucleotide results in decreased expression of CCNA2 protein
CTD PMID:12730239 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 multiple interactions
decreases expression
ISO AICA ribonucleotide inhibits the reaction [ELAVL1 protein binds to CCNB1 3' UTR]
AICA ribonucleotide results in decreased expression of CCNB1 mRNA; AICA ribonucleotide results in decreased expression of CCNB1 protein
CTD PMID:12730239 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO AICA ribonucleotide results in increased expression of and affects the localization of CD36 protein CTD PMID:28038998 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression
multiple interactions
ISO AICA ribonucleotide results in decreased expression of CEBPA protein
AICA ribonucleotide inhibits the reaction [fipronil results in increased expression of CEBPA protein]
CTD PMID:27103584 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases phosphorylation ISO AICA ribonucleotide results in increased phosphorylation of CEBPB protein CTD PMID:28038998 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions EXP AICA ribonucleotide inhibits the reaction [Colforsin results in increased activity of CFTR protein] CTD PMID:12519745 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO AICA ribonucleotide inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein] CTD PMID:27688165 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression
multiple interactions
ISO AICA ribonucleotide results in increased expression of CPT1A mRNA; AICA ribonucleotide results in increased expression of CPT1A protein
AICA ribonucleotide inhibits the reaction [TP53 gene mutant form results in increased expression of CPT1A protein]
dorsomorphin inhibits the reaction [AICA ribonucleotide results in increased expression of CPT1A mRNA]
CTD PMID:24465016 PMID:25743752 PMID:33070465 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B multiple interactions EXP AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of CPT1B mRNA]; AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of CPT1B protein] CTD PMID:19699196 NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases expression
ISO [AICA ribonucleotide results in increased phosphorylation of HDAC5 protein] which results in increased expression of CTNNB1 mRNA; [AICA ribonucleotide results in increased phosphorylation of HDAC5 protein] which results in increased expression of CTNNB1 protein; AICA ribonucleotide inhibits the reaction [[HDAC5 protein binds to MEF2 protein] which binds to CTNNB1 promoter]; PRKAA2 protein affects the reaction [AICA ribonucleotide results in increased expression of CTNNB1 mRNA]; PRKAA2 protein affects the reaction [AICA ribonucleotide results in increased expression of CTNNB1 protein]
AICA ribonucleotide results in increased expression of CTNNB1 mRNA; AICA ribonucleotide results in increased expression of CTNNB1 protein
CTD PMID:21454484 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions EXP AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased expression of CYBA protein] CTD PMID:21195169 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased expression of CYBB protein] CTD PMID:21195169 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions EXP AICA ribonucleotide promotes the reaction [NR1I3 protein results in increased expression of CYP2B10 mRNA]; PRKAA2 protein promotes the reaction [AICA ribonucleotide promotes the reaction [NR1I3 protein results in increased expression of CYP2B10 mRNA]] CTD PMID:22815988 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO AICA ribonucleotide inhibits the reaction [EGFR protein results in increased import of Deoxyglucose] CTD PMID:19625624 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha decreases phosphorylation ISO AICA ribonucleotide results in decreased phosphorylation of EIF2S1 protein CTD PMID:22898769 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions
decreases phosphorylation
ISO
EXP
AICA ribonucleotide inhibits the reaction [AKT1 protein mutant form results in increased phosphorylation of EIF4EBP1 protein]
AICA ribonucleotide results in decreased phosphorylation of EIF4EBP1 protein
AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EIF4EBP1 protein]
CTD PMID:15806154 PMID:21195169 PMID:28041982 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Elavl1 ELAV like RNA binding protein 1 multiple interactions
decreases localization
ISO AICA ribonucleotide inhibits the reaction [ELAVL1 protein binds to CCNA2 3' UTR]; AICA ribonucleotide inhibits the reaction [ELAVL1 protein binds to CCNB1 3' UTR]
AICA ribonucleotide results in decreased localization of ELAVL1 protein
CTD PMID:12730239 NCBI chr12:2,640,936...2,684,787
Ensembl chr12:2,645,061...2,684,784
JBrowse link
G Foxo1 forkhead box O1 multiple interactions
increases expression
increases phosphorylation
increases activity
ISO AICA ribonucleotide promotes the reaction [FOXO1 protein results in increased expression of CAT mRNA]; AICA ribonucleotide promotes the reaction [FOXO1 protein results in increased expression of SOD2 mRNA]
AICA ribonucleotide results in increased expression of FOXO1 protein
AICA ribonucleotide results in increased phosphorylation of FOXO1 protein
AICA ribonucleotide results in increased activity of FOXO1 protein
CTD PMID:25065674 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP AICA ribonucleotide inhibits the reaction [[IGF1 protein co-treated with FSHB protein] results in increased phosphorylation of MAPK1 protein]; AICA ribonucleotide inhibits the reaction [[IGF1 protein co-treated with FSHB protein] results in increased phosphorylation of MAPK3 protein]; AICA ribonucleotide inhibits the reaction [FSHB protein results in increased phosphorylation of MAPK3 protein] CTD PMID:16020477 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression EXP AICA ribonucleotide results in decreased expression of G6PC1 mRNA CTD PMID:19664596 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
JBrowse link
G Gpr68 G protein-coupled receptor 68 multiple interactions ISO AICA ribonucleotide inhibits the reaction [TNF protein promotes the reaction [Oxygen deficiency results in increased expression of GPR68 mRNA]]; AICA ribonucleotide inhibits the reaction [TNF protein results in increased expression of GPR68 mRNA] CTD PMID:28174749 NCBI chr 6:120,135,620...120,166,089
Ensembl chr 6:120,135,436...120,166,089
JBrowse link
G Grb2 growth factor receptor bound protein 2 multiple interactions EXP GRB2 protein affects the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein] CTD PMID:11978788 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 increases expression ISO AICA ribonucleotide results in increased expression of GSTK1 protein CTD PMID:20980258 NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292
JBrowse link
G Hdac5 histone deacetylase 5 multiple interactions
increases phosphorylation
ISO [AICA ribonucleotide results in increased phosphorylation of HDAC5 protein] which results in increased expression of CTNNB1 mRNA; [AICA ribonucleotide results in increased phosphorylation of HDAC5 protein] which results in increased expression of CTNNB1 protein; AICA ribonucleotide inhibits the reaction [[HDAC5 protein binds to MEF2 protein] which binds to CTNNB1 promoter] CTD PMID:21454484 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha decreases expression ISO AICA ribonucleotide results in decreased expression of HNF4A mRNA CTD PMID:24428821 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression EXP AICA ribonucleotide results in decreased expression of HSD3B1 mRNA; AICA ribonucleotide results in decreased expression of HSD3B1 protein CTD PMID:16020477 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions EXP AICA ribonucleotide inhibits the reaction [[IGF1 protein co-treated with FSHB protein] results in increased phosphorylation of MAPK1 protein]; AICA ribonucleotide inhibits the reaction [[IGF1 protein co-treated with FSHB protein] results in increased phosphorylation of MAPK3 protein]; AICA ribonucleotide inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein] CTD PMID:16020477 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; dorsomorphin inhibits the reaction [AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; dorsomorphin inhibits the reaction [AICA ribonucleotide results in decreased expression of IL1B mRNA] CTD PMID:24465016 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
EXP
ISO
AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased expression of IL6 mRNA]
AICA ribonucleotide results in decreased expression of IL6 mRNA
AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; dorsomorphin inhibits the reaction [AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; dorsomorphin inhibits the reaction [AICA ribonucleotide results in decreased expression of IL6 mRNA]
CTD PMID:24465016 PMID:25108154 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins1 insulin 1 multiple interactions ISO AICA ribonucleotide inhibits the reaction [INS1 protein results in increased phosphorylation of TBC1D1 protein]; AICA ribonucleotide inhibits the reaction [INS1 protein results in increased phosphorylation of TBC1D4 protein] CTD PMID:24343960 PMID:26627467 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
JBrowse link
G Insr insulin receptor multiple interactions
decreases activity
decreases expression
ISO 5'-amino-5'-deoxyadenosine inhibits the reaction [AICA ribonucleotide results in decreased activity of INSR promoter]; 5'-amino-5'-deoxyadenosine inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR mRNA]; 5'-amino-5'-deoxyadenosine inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR protein]; Dipyridamole inhibits the reaction [AICA ribonucleotide results in decreased activity of INSR promoter]; Dipyridamole inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR mRNA]; Dipyridamole inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR protein]
AICA ribonucleotide results in decreased expression of INSR mRNA; AICA ribonucleotide results in decreased expression of INSR protein
CTD PMID:15694368 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 affects response to substance ISO KCNJ11 protein affects the susceptibility to AICA ribonucleotide CTD PMID:24498880 NCBI chr 1:96,591,048...96,594,574
Ensembl chr 1:96,591,049...96,594,082
JBrowse link
G Klf15 KLF transcription factor 15 decreases expression ISO AICA ribonucleotide results in decreased expression of KLF15 mRNA CTD PMID:24428821 NCBI chr 4:122,965,718...122,978,403
Ensembl chr 4:122,965,807...122,978,374
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 increases activity EXP AICAR increases activity of Map3k7 protein in cardiac muscle cells RGD PMID:17085580 RGD:155791450 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
decreases phosphorylation
EXP
ISO
AICA ribonucleotide inhibits the reaction [[IGF1 protein co-treated with FSHB protein] results in increased phosphorylation of MAPK1 protein]; AICA ribonucleotide inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]
AICA ribonucleotide results in increased phosphorylation of MAPK1 protein
AICA ribonucleotide results in decreased phosphorylation of MAPK1 protein
CTD PMID:16020477 PMID:28038998 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
decreases phosphorylation
EXP
ISO
AICA ribonucleotide inhibits the reaction [[IGF1 protein co-treated with FSHB protein] results in increased phosphorylation of MAPK3 protein]; AICA ribonucleotide inhibits the reaction [FSHB protein results in increased phosphorylation of MAPK3 protein]; MAPK3 protein affects the reaction [AICA ribonucleotide results in increased uptake of Deoxyglucose]; PTK2B protein affects the reaction [AICA ribonucleotide results in increased activity of MAPK3 protein]
AICA ribonucleotide results in increased phosphorylation of MAPK3 protein
AICA ribonucleotide results in decreased phosphorylation of MAPK3 protein
CTD PMID:11978788 PMID:16020477 PMID:28038998 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mfn1 mitofusin 1 multiple interactions EXP AICA ribonucleotide inhibits the reaction [Acetaminophen results in decreased expression of MFN1 protein]; AICA ribonucleotide inhibits the reaction [Diclofenac results in decreased expression of MFN1 protein] CTD PMID:27792760 NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640
JBrowse link
G Mfn2 mitofusin 2 multiple interactions EXP AICA ribonucleotide inhibits the reaction [Acetaminophen results in decreased expression of MFN2 protein]; AICA ribonucleotide inhibits the reaction [Diclofenac results in decreased expression of MFN2 protein] CTD PMID:27792760 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO AICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased expression of MMP13 protein] CTD PMID:27688165 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases activity ISO AICA ribonucleotide results in decreased activity of MMP2 protein CTD PMID:20590612 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity ISO AICA ribonucleotide results in decreased activity of MMP9 protein CTD PMID:20590612 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpst mercaptopyruvate sulfurtransferase decreases expression EXP AICA ribonucleotide results in decreased expression of MPST mRNA CTD PMID:35577173 NCBI chr 7:109,955,581...109,963,155
Ensembl chr 7:109,955,675...109,963,141
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases activity
decreases phosphorylation
multiple interactions
ISO
EXP
AICA ribonucleotide results in decreased activity of MTOR protein
AICA ribonucleotide results in decreased phosphorylation of MTOR protein
AICA ribonucleotide promotes the reaction [4-nonylphenol results in decreased phosphorylation of MTOR protein]
AICA ribonucleotide promotes the reaction [Cadmium results in decreased phosphorylation of MTOR protein]
CTD PMID:19625624 PMID:21767558 PMID:27363783 PMID:28041982 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions EXP AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased expression of NCF1 protein] CTD PMID:21195169 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 multiple interactions EXP AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased expression of NCF2 protein] CTD PMID:21195169 NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277
JBrowse link
G Ncf4 neutrophil cytosolic factor 4 multiple interactions EXP AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased expression of NCF4 protein] CTD PMID:21195169 NCBI chr 7:109,825,420...109,843,389
Ensembl chr 7:109,826,020...109,843,389
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased localization of NFKB1 protein] CTD PMID:22025971 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO
AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA]
AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; dorsomorphin inhibits the reaction [AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]
CTD PMID:24465016 PMID:25108154 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP AICA ribonucleotide inhibits the reaction [Palmitic Acid inhibits the reaction [Acetylcholine results in increased phosphorylation of NOS3 protein]] CTD PMID:25108154 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression ISO AICA ribonucleotide results in decreased expression of NR0B2 mRNA CTD PMID:24428821 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression EXP AICA ribonucleotide results in decreased expression of NR1H4 mRNA; AICA ribonucleotide results in decreased expression of NR1H4 protein CTD PMID:27090119 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions EXP AICA ribonucleotide inhibits the reaction [Phenobarbital results in increased localization of and results in increased activity of NR1I3 protein]; AICA ribonucleotide promotes the reaction [NR1I3 protein results in increased expression of CYP2B10 mRNA]; PRKAA2 protein promotes the reaction [AICA ribonucleotide promotes the reaction [NR1I3 protein results in increased expression of CYP2B10 mRNA]] CTD PMID:20686344 PMID:22815988 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions
increases expression
EXP dorsomorphin inhibits the reaction [AICA ribonucleotide results in increased expression of NRF1 mRNA] CTD PMID:20438809 NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions EXP AICA ribonucleotide inhibits the reaction [Acetaminophen results in decreased expression of OPA1 protein]; AICA ribonucleotide inhibits the reaction [Diclofenac results in decreased expression of OPA1 protein] CTD PMID:27792760 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of PPARA mRNA]; AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of PPARA protein] CTD PMID:19699196 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP
ISO
AICA ribonucleotide inhibits the reaction [Palmitic Acid results in decreased expression of PPARG mRNA]
AICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased expression of PPARG protein]
CTD PMID:25108154 PMID:27688165 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions
increases expression
decreases expression
EXP
ISO
dorsomorphin inhibits the reaction [AICA ribonucleotide results in increased expression of PPARGC1A mRNA]
AICA ribonucleotide results in decreased expression of PPARGC1A mRNA
AICA ribonucleotide inhibits the reaction [Glucose results in decreased expression of PPARGC1A protein]; dorsomorphin promotes the reaction [AICA ribonucleotide results in decreased expression of PPARGC1A mRNA]
AICA ribonucleotide inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of PPARGC1A protein]
CTD PMID:20438809 PMID:23090186 PMID:24428821 PMID:25522270 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases phosphorylation
multiple interactions
increases expression
increases activity
EXP
ISO
AICA ribonucleotide results in increased phosphorylation of PRKAA1 protein
AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of PRKAA1 protein]; dorsomorphin inhibits the reaction [AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of PRKAA1 protein]]; dorsomorphin inhibits the reaction [AICA ribonucleotide results in increased phosphorylation of PRKAA1 protein]
AICA ribonucleotide promotes the reaction [Quercetin results in increased phosphorylation of and results in increased activity of PRKAA1 protein]; AICA ribonucleotide results in increased phosphorylation of and results in increased activity of PRKAA1 protein; PRKAA1 protein affects the reaction [AICA ribonucleotide results in increased expression of CYP4F2 mRNA]; Quercetin promotes the reaction [AICA ribonucleotide results in increased phosphorylation of and results in increased activity of PRKAA1 protein]
AICA ribonucleotide results in increased expression of PRKAA1 protein modified form
[AICA ribonucleotide results in increased phosphorylation of PRKAA1 protein] which results in decreased secretion of Progesterone; AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in decreased phosphorylation of PRKAA1 protein]; AICA ribonucleotide inhibits the reaction [Sodium Chloride, Dietary results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]; AICA ribonucleotide inhibits the reaction [Sodium Chloride, Dietary results in increased expression of PRKAA1 mRNA]
AICA ribonucleotide results in increased activity of PRKAA1 protein
CTD PMID:12519745 PMID:16020477 PMID:16873680 PMID:19293639 PMID:20349193 More... NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions
increases phosphorylation
ISO
EXP
AICA ribonucleotide results in increased phosphorylation of and results in increased activity of PRKAA2 protein; PRKAA2 protein affects the reaction [AICA ribonucleotide results in increased expression of CYP4F2 mRNA]
PRKAA2 protein promotes the reaction [AICA ribonucleotide promotes the reaction [NR1I3 protein results in increased expression of CYP2B10 mRNA]]
AICA ribonucleotide results in increased phosphorylation of PRKAA2 protein
PRKAA2 protein affects the reaction [AICA ribonucleotide inhibits the reaction [AKT1 protein mutant form affects the susceptibility to Glucose deficiency]]; PRKAA2 protein affects the reaction [AICA ribonucleotide results in increased expression of CTNNB1 mRNA]; PRKAA2 protein affects the reaction [AICA ribonucleotide results in increased expression of CTNNB1 protein]
CTD PMID:15806154 PMID:16873680 PMID:18482975 PMID:21205922 PMID:21454484 More... NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543
JBrowse link
G Prkcz protein kinase C, zeta multiple interactions
increases activity
EXP 1-Butanol inhibits the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein]; Genistein inhibits the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein]; GRB2 protein affects the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein]; PTK2B protein affects the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein] CTD PMID:11978788 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
JBrowse link
G Pten phosphatase and tensin homolog increases response to substance ISO PTEN protein results in increased susceptibility to AICA ribonucleotide CTD PMID:19625624 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:22025971 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta multiple interactions EXP AICA ribonucleotide results in increased phosphorylation of and results in increased activity of PTK2B protein; PTK2B protein affects the reaction [AICA ribonucleotide results in increased activity of MAPK3 protein]; PTK2B protein affects the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein] CTD PMID:11978788 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions EXP AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased expression of RAC1 protein] CTD PMID:21195169 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions EXP RAF1 protein affects the reaction [AICA ribonucleotide results in increased uptake of Deoxyglucose] CTD PMID:11978788 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
AICA ribonucleotide inhibits the reaction [Streptozocin results in increased phosphorylation of and results in increased activity of RELA protein]
AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased phosphorylation of RELA protein]; dorsomorphin inhibits the reaction [AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased phosphorylation of RELA protein]]; Niacinamide inhibits the reaction [AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased phosphorylation of RELA protein]]
CTD PMID:22058332 PMID:25108154 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation ISO AICA ribonucleotide results in decreased phosphorylation of RPS6 protein CTD PMID:19625624 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
decreases phosphorylation
increases phosphorylation
EXP AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]; naringin inhibits the reaction [AICA ribonucleotide results in increased phosphorylation of RPS6KB1 protein]
AICA ribonucleotide results in decreased phosphorylation of RPS6KB1 protein
CTD PMID:15342961 PMID:21195169 PMID:28041982 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Sirt1 sirtuin 1 multiple interactions
increases expression
ISO
EXP
AICA ribonucleotide inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]; AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]; AICA ribonucleotide inhibits the reaction [Streptozocin results in decreased activity of SIRT1 protein]; dorsomorphin inhibits the reaction [AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]]; dorsomorphin inhibits the reaction [AICA ribonucleotide results in increased expression of SIRT1 protein]
AICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased expression of SIRT1 protein]
[Niacinamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to AICA ribonucleotide
CTD PMID:22058332 PMID:23090186 PMID:24465016 PMID:25108154 PMID:27688165 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression EXP AICA ribonucleotide results in decreased expression of SLC10A1 mRNA CTD PMID:27090119 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
G Slc15a1 solute carrier family 15 member 1 decreases activity ISO AICA ribonucleotide results in decreased activity of SLC15A1 protein CTD PMID:22108913 NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions
increases localization
EXP
ISO
1-Butanol inhibits the reaction [AICA ribonucleotide results in increased localization of SLC2A4 protein]; Genistein inhibits the reaction [AICA ribonucleotide results in increased localization of SLC2A4 protein]; U 0126 inhibits the reaction [AICA ribonucleotide results in increased localization of SLC2A4 protein]; wortmannin inhibits the reaction [AICA ribonucleotide results in increased localization of SLC2A4 protein]
AICA ribonucleotide inhibits the reaction [Palmitates results in decreased expression of SLC2A4 mRNA]
CTD PMID:11978788 PMID:21802492 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 decreases expression EXP AICA ribonucleotide results in decreased expression of SLCO1A2 mRNA CTD PMID:27090119 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
ISO AICA ribonucleotide promotes the reaction [FOXO1 protein results in increased expression of SOD2 mRNA]
AICA ribonucleotide results in increased expression of SOD2 mRNA; AICA ribonucleotide results in increased expression of SOD2 protein
CTD PMID:25065674 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression
ISO [AICA ribonucleotide co-treated with Sirolimus] results in increased expression of SQSTM1 protein; TP53 gene mutant form promotes the reaction [AICA ribonucleotide results in increased expression of SQSTM1 protein] CTD PMID:33070465 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Stk11 serine/threonine kinase 11 multiple interactions ISO AICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased phosphorylation of STK11 protein] CTD PMID:27688165 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315
JBrowse link
G Tbc1d1 TBC1 domain family member 1 multiple interactions ISO AICA ribonucleotide inhibits the reaction [INS1 protein results in increased phosphorylation of TBC1D1 protein] CTD PMID:26627467 NCBI chr14:43,936,820...44,135,133
Ensembl chr14:43,935,636...44,136,499
JBrowse link
G Tbc1d4 TBC1 domain family, member 4 multiple interactions ISO AICA ribonucleotide inhibits the reaction [INS1 protein results in increased phosphorylation of TBC1D4 protein] CTD PMID:24343960 PMID:26627467 NCBI chr15:78,256,030...78,434,168
Ensembl chr15:78,257,121...78,434,265
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO AICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased expression of MMP13 protein]; AICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased expression of PPARG protein]; AICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased expression of SIRT1 protein]; AICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased phosphorylation of STK11 protein]; AICA ribonucleotide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; AICA ribonucleotide inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; AICA ribonucleotide inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 protein] CTD PMID:27688165 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO AICA ribonucleotide inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 protein] CTD PMID:27688165 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
AICA ribonucleotide inhibits the reaction [TNF protein promotes the reaction [Oxygen deficiency results in increased expression of GPR68 mRNA]]; AICA ribonucleotide inhibits the reaction [TNF protein results in increased expression of GPR68 mRNA]
AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased expression of TNF mRNA]
CTD PMID:22025971 PMID:25108154 PMID:28174749 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions ISO AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF1A protein] CTD PMID:22025971 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases phosphorylation
ISO [Resveratrol co-treated with AICA ribonucleotide] inhibits the reaction [Glucose results in increased expression of TP53 protein]; AICA ribonucleotide inhibits the reaction [TP53 gene mutant form results in increased expression of CPT1A protein]; AICA ribonucleotide promotes the reaction [TP53 gene mutant form results in increased phosphorylation of ULK1 protein]; TP53 gene mutant form promotes the reaction [AICA ribonucleotide results in increased expression of SQSTM1 protein]; TP53 gene mutant form promotes the reaction [AICA ribonucleotide results in increased phosphorylation of ULK1 protein]
AICA ribonucleotide results in increased phosphorylation of TP53 protein
CTD PMID:26188290 PMID:33070465 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Txnip thioredoxin interacting protein multiple interactions ISO AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased expression of TXNIP protein] CTD PMID:29031535 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions EXP AICA ribonucleotide inhibits the reaction [Indican results in decreased expression of UCP2 mRNA] CTD PMID:25703824 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 multiple interactions ISO AICA ribonucleotide promotes the reaction [TP53 gene mutant form results in increased phosphorylation of ULK1 protein]; AICA ribonucleotide results in increased expression of and results in increased phosphorylation of ULK1 protein; TP53 gene mutant form promotes the reaction [AICA ribonucleotide results in increased phosphorylation of ULK1 protein] CTD PMID:33070465 NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO AICA ribonucleotide inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased secretion of VEGFA protein] CTD PMID:30724446 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Xpo1 exportin 1 multiple interactions ISO AICA ribonucleotide promotes the reaction [ABL1 protein mutant form binds to XPO1 protein]; AICA ribonucleotide promotes the reaction [XPO1 protein binds to BECN1 protein]; AICA ribonucleotide promotes the reaction [XPO1 protein binds to YWHAQ protein] CTD PMID:33070465 NCBI chr14:97,233,282...97,275,536
Ensembl chr14:97,233,270...97,275,498
JBrowse link
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta multiple interactions ISO AICA ribonucleotide promotes the reaction [ABL1 protein mutant form binds to YWHAQ protein]; AICA ribonucleotide promotes the reaction [XPO1 protein binds to YWHAQ protein] CTD PMID:33070465 NCBI chr 6:40,935,714...40,966,240
Ensembl chr 6:40,935,949...40,966,273
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      application 19729
        pharmaceutical 19565
          drug 19565
            antineoplastic agent 17770
              acadesine 136
                AICA ribonucleotide 108
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic group 18995
                              organic divalent group 18969
                                organodiyl group 18969
                                  carbonyl group 18922
                                    carbonyl compound 18922
                                      carboxylic acid 18646
                                        carboacyl group 17727
                                          univalent carboacyl group 17727
                                            carbamoyl group 17575
                                              carboxamide 17575
                                                monocarboxylic acid amide 15699
                                                  1-ribosylimidazolecarboxamide 137
                                                    acadesine 136
                                                      AICA ribonucleotide 108
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