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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:reserpine
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Accession:CHEBI:28487 term browser browse the term
Definition:An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
Synonyms:exact_synonym: methyl (3beta,16beta,17alpha,18beta,20alpha)-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylate
 related_synonym: (3beta,16beta,17alpha,18beta,20alpha)-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester;   3,4,5-trimethoxybenzoyl methyl reserpate;   Apoplon;   Formula=C33H40N2O9;   InChI=1S/C33H40N2O9/c1-38-19-7-8-20-21-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)22(18)15-24(35)29(21)34-23(20)14-19/h7-8,11-12,14,18,22,24,27-28,31,34H,9-10,13,15-16H2,1-6H3/t18-,22+,24-,27-,28+,31+/m1/s1;   InChIKey=QEVHRUUCFGRFIF-MDEJGZGSSA-N;   Reserpin;   SMILES=[H][C@]12C[C@@H](OC(=O)c3cc(OC)c(OC)c(OC)c3)[C@H](OC)[C@@H](C(=O)OC)[C@@]1([H])C[C@@]1([H])N(CCc3c1[nH]c1cc(OC)ccc31)C2;   Serpalan
 alt_id: CHEBI:26531;   CHEBI:8808
 xref: Beilstein:5326088;   CAS:50-55-5;   DrugBank:DB00206;   Drug_Central:2370;   HMDB:HMDB0014351;   KEGG:C06539;   KEGG:D00197;   KNApSAcK:C00001763;   LINCS:LSM-4162
 xref_mesh: MESH:D012110
 xref: PMID:20701244;   PMID:20825390;   PMID:24603678;   Reaxys:102014;   Wikipedia:Reserpine


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reserpine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity 		ISO Reserpine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Reserpine results in decreased activity of ABCB11 protein 		CTD PMID:20829430 PMID:23956101 PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases activity
increases expression 		ISO Cycloheximide promotes the reaction [Reserpine results in increased expression of ABCB1 mRNA]; Reserpine inhibits the reaction [ABCB1 protein affects the export of calcein AM]; Reserpine inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Reserpine inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]
Reserpine results in decreased activity of ABCB1 protein
Reserpine results in increased expression of ABCB1 mRNA; Reserpine results in increased expression of ABCB1 protein
Reserpine inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon] 		CTD PMID:7476894 PMID:8632764 PMID:10617675 PMID:12235267 PMID:19528478 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Reserpine inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Reserpine inhibits the reaction [ABCG2 protein results in increased transport of Irinotecan] CTD PMID:12869632 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Ache acetylcholinesterase multiple interactions
affects activity 		EXP [Plant Extracts results in increased abundance of Dronabinol] inhibits the reaction [Reserpine affects the activity of ACHE protein] CTD PMID:28212939 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Adra1d adrenoceptor alpha 1D increases response to substance
increases expression 		EXP ADRA1D protein results in increased susceptibility to Reserpine
Reserpine results in increased expression of ADRA1D mRNA 		CTD PMID:15159276 PMID:17676312 NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354 		JBrowse link
G Adra2a adrenoceptor alpha 2A increases expression EXP Reserpine results in increased expression of ADRA2A mRNA CTD PMID:11264240 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Adrb1 adrenoceptor beta 1 increases expression
increases stability 		EXP Reserpine results in increased expression of ADRB1 mRNA; Reserpine results in increased expression of ADRB1 protein
Reserpine results in increased stability of ADRB1 mRNA 		CTD PMID:1336118 NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Adrb2 adrenoceptor beta 2 increases expression EXP Reserpine results in increased expression of ADRB2 mRNA CTD PMID:1664493 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 increases expression EXP Reserpine results in increased expression of AGTR2 mRNA; Reserpine results in increased expression of AGTR2 protein CTD PMID:20964730 NCBI chr  X:112,119,876...112,124,060
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO Reserpine results in increased expression of AKR1B10 mRNA CTD PMID:26198647 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions 		ISO Reserpine results in decreased phosphorylation of AKT1 protein
arsenic trioxide promotes the reaction [Reserpine results in decreased phosphorylation of AKT1 protein] 		CTD PMID:26114099 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Amd1 adenosylmethionine decarboxylase 1 multiple interactions ISO Reserpine inhibits the reaction [Folic Acid results in increased activity of AMD1 protein] CTD PMID:17371283 NCBI chr20:43,695,783...43,711,476
Ensembl chr20:43,697,237...43,711,476 		JBrowse link
G Ar androgen receptor multiple interactions ISO Reserpine inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein] CTD PMID:29162470 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Arc activity-regulated cytoskeleton-associated protein multiple interactions EXP Reserpine inhibits the reaction [Cocaine results in increased expression of ARC mRNA] CTD PMID:7722525 NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression 		EXP IAPP protein inhibits the reaction [Reserpine results in increased expression of BAX protein] CTD PMID:19463876 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression 		EXP IAPP protein inhibits the reaction [Reserpine results in decreased expression of BCL2 protein] CTD PMID:19463876 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression
multiple interactions 		ISO
EXP 		Reserpine results in decreased expression of BDNF protein
arsenic trioxide promotes the reaction [Reserpine results in decreased expression of BDNF protein]
cerebrolysin inhibits the reaction [Reserpine results in decreased expression of BDNF protein]; Fluoxetine inhibits the reaction [Reserpine results in decreased expression of BDNF protein] 		CTD PMID:26114099 PMID:33279466 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 affects binding ISO Reserpine binds to BIRC5 promoter CTD PMID:17968851 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G C3 complement C3 affects expression EXP Reserpine affects the expression of C3 mRNA CTD PMID:18363858 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity 		EXP IAPP protein inhibits the reaction [Reserpine results in increased activity of CASP3 protein] CTD PMID:19463876 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity 		EXP IAPP protein inhibits the reaction [Reserpine results in increased activity of CASP8 protein] CTD PMID:19463876 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Cat catalase multiple interactions
increases expression
decreases expression 		EXP Plant Extracts inhibits the reaction [Reserpine results in decreased expression of CAT protein]; Quercetin inhibits the reaction [Reserpine results in decreased expression of CAT protein]
Reserpine results in increased expression of CAT protein 		CTD PMID:14685008 PMID:16444668 PMID:19109989 PMID:19761039 PMID:20628966 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Reserpine results in decreased expression of CCND1 mRNA; Reserpine results in decreased expression of CCND1 protein CTD PMID:19607803 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions EXP [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of CDKN1B protein CTD PMID:11318962 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions EXP [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine] inhibits the reaction [Desoxycorticosterone Acetate affects the localization of CDKN2A protein]; [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine] inhibits the reaction [Desoxycorticosterone Acetate results in increased expression of CDKN2A mRNA] CTD PMID:18504326 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Chga chromogranin A multiple interactions
increases activity
increases expression 		ISO
EXP 		CHGA protein alternative form inhibits the reaction [Reserpine results in increased activity of CHGA promoter]; Chlorisondamine inhibits the reaction [Reserpine results in increased activity of CHGA promoter]
Reserpine results in increased expression of CHGA mRNA 		CTD PMID:1907749 PMID:8189248 PMID:12799369 NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398 		JBrowse link
G Chgb chromogranin B increases expression EXP Reserpine results in increased expression of CHGB mRNA; Reserpine results in increased expression of CHGB protein CTD PMID:1907749 PMID:8189248 PMID:8361347 NCBI chr 3:120,043,824...120,057,169
Ensembl chr 3:120,043,738...120,057,166 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 increases expression
decreases expression 		EXP Reserpine results in increased expression of CHRM1 mRNA
Reserpine results in decreased expression of CHRM1 protein 		CTD PMID:1506860 NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356 		JBrowse link
G Cnr1 cannabinoid receptor 1 decreases expression EXP Reserpine results in decreased expression of CNR1 mRNA CTD PMID:11358453 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Cpe carboxypeptidase E increases expression EXP Reserpine results in increased expression of CPE mRNA CTD PMID:8189248 NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233 		JBrowse link
G Crem cAMP responsive element modulator multiple interactions
increases expression 		EXP Reserpine promotes the reaction [CREM protein binds to TH promoter]
Reserpine results in increased expression of CREM mRNA alternative form; Reserpine results in increased expression of CREM protein; Reserpine results in increased expression of CREM protein alternative form 		CTD PMID:8810303 PMID:11438978 NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989 		JBrowse link
G Crh corticotropin releasing hormone increases expression EXP Reserpine results in increased expression of CRH mRNA; Reserpine results in increased expression of CRH protein CTD PMID:1850078 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Reserpine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Reserpine promotes the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A1 protein]; Reserpine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] CTD PMID:15627480 PMID:18493746 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP [Reserpine results in decreased abundance of Catecholamines] promotes the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A2 protein]; [Reserpine results in decreased abundance of Catecholamines] promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; Reserpine promotes the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A2 protein]; Reserpine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA] CTD PMID:16510159 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO [Reserpine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA CTD PMID:17041008 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions 		ISO Reserpine results in increased expression of CYP3A4 mRNA; Reserpine results in increased expression of CYP3A4 protein
[Reserpine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; Reserpine inhibits the reaction [Calcitriol results in increased expression of CYP3A4 protein] 		CTD PMID:8632764 PMID:16837568 PMID:17041008 PMID:29782822 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression ISO Reserpine results in increased expression of CYP3A5 protein CTD PMID:8632764 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Cyss cystatin S multiple interactions EXP Reserpine inhibits the reaction [Isoproterenol results in increased expression of CYSS mRNA] CTD PMID:9447264 NCBI chr 3:137,432,049...137,436,654
Ensembl chr 3:137,432,049...137,436,610 		JBrowse link
G Dbh dopamine beta-hydroxylase decreases activity
increases activity
increases stability
increases expression 		EXP Reserpine results in decreased activity of DBH protein
Reserpine results in increased activity of DBH protein
Reserpine results in increased stability of DBH protein
Reserpine results in increased expression of DBH mRNA 		CTD PMID:1359376 PMID:2325165 PMID:7984052 PMID:8189248 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248 		JBrowse link
G Ddc dopa decarboxylase increases expression EXP Reserpine results in increased expression of DDC mRNA CTD PMID:1359376 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208 		JBrowse link
G Drd1 dopamine receptor D1 increases expression EXP Reserpine results in increased expression of DRD1 mRNA CTD PMID:8419537 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
increases expression 		ISO
EXP 		DRD2 protein affects the susceptibility to [8-(3-chlorostyryl)caffeine co-treated with Reserpine]
Reserpine results in increased expression of DRD2 mRNA; Reserpine results in increased expression of DRD2 mRNA alternative form 		CTD PMID:1331675 PMID:8419537 PMID:11172060 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression 		EXP [Reserpine co-treated with Levodopa] results in increased expression of EGR1 mRNA; eticlopride inhibits the reaction [[Reserpine co-treated with Levodopa] results in increased expression of EGR1 mRNA]; Quinpirole inhibits the reaction [Reserpine results in increased expression of EGR1 mRNA]; Reserpine promotes the reaction [Dextroamphetamine results in increased expression of EGR1 mRNA]; SCH 23390 inhibits the reaction [[Reserpine co-treated with Levodopa] results in increased expression of EGR1 mRNA]; SCH 23390 inhibits the reaction [Reserpine promotes the reaction [Dextroamphetamine results in increased expression of EGR1 mRNA]]
Reserpine results in increased expression of EGR1 mRNA; Reserpine results in increased expression of EGR1 protein 		CTD PMID:1347779 PMID:8063705 PMID:9729266 PMID:9890435 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 increases response to substance EXP ERBB2 protein results in increased susceptibility to Reserpine CTD PMID:8093862 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Fabp7 fatty acid binding protein 7 affects expression EXP Reserpine affects the expression of FABP7 mRNA CTD PMID:18363858 NCBI chr20:37,123,193...37,126,725
Ensembl chr20:37,123,193...37,126,880 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases phosphorylation
increases expression 		EXP 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine promotes the reaction [Reserpine results in increased expression of FOS protein]; 3,7-dimethyl-1-propargylxanthine inhibits the reaction [Reserpine results in increased expression of FOS protein]; 8-(3-chlorostyryl)caffeine promotes the reaction [Quinpirole inhibits the reaction [Reserpine results in increased expression of FOS protein]]; Quinpirole inhibits the reaction [Reserpine results in increased expression of FOS protein]; Quinpirole promotes the reaction [Reserpine results in increased expression of FOS protein]; Reserpine inhibits the reaction [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Quinpirole] results in increased expression of FOS protein]; Reserpine inhibits the reaction [Cocaine results in increased expression of FOS protein]; Reserpine promotes the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of FOS protein]; Reserpine promotes the reaction [Amphetamine results in increased expression of FOS protein]; Reserpine promotes the reaction [Quinpirole results in increased expression of FOS protein]; Theophylline inhibits the reaction [Reserpine results in increased expression of FOS protein]
Reserpine results in increased phosphorylation of FOS protein
Reserpine results in increased expression of FOS mRNA; Reserpine results in increased expression of FOS protein 		CTD PMID:1359376 PMID:1686849 PMID:2118661 PMID:7845612 PMID:7914358 More... NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gad1 glutamate decarboxylase 1 increases expression
multiple interactions 		EXP Reserpine results in increased expression of GAD1 mRNA
Clenbuterol inhibits the reaction [Reserpine results in increased expression of GAD1 mRNA] 		CTD PMID:8774452 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333 		JBrowse link
G Gal galanin and GMAP prepropeptide decreases expression
multiple interactions
increases expression 		EXP Reserpine results in decreased expression of GAL mRNA
Desipramine inhibits the reaction [Reserpine results in increased expression of GAL mRNA] 		CTD PMID:1279347 PMID:1698642 PMID:1705056 PMID:1717808 PMID:9512271 More... NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959 		JBrowse link
G Gast gastrin multiple interactions EXP Reserpine inhibits the reaction [Levodopa results in decreased cleavage of GAST protein] CTD PMID:10332097 NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496 		JBrowse link
G Gch1 GTP cyclohydrolase 1 increases expression EXP Reserpine results in increased expression of GCH1 mRNA; Reserpine results in increased expression of GCH1 mRNA alternative form CTD PMID:8103077 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
G Gcnt3 glucosaminyl (N-acetyl) transferase 3, mucin type increases expression ISO Reserpine results in increased expression of GCNT3 mRNA CTD PMID:26198647 NCBI chr 8:70,689,173...70,696,476
Ensembl chr 8:70,686,844...70,699,562 		JBrowse link
G Gnai1 G protein subunit alpha i1 increases expression EXP Reserpine results in increased expression of GNAI1 protein CTD PMID:11264240 NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417 		JBrowse link
G Gnai2 G protein subunit alpha i2 increases expression EXP Reserpine results in increased expression of GNAI2 mRNA; Reserpine results in increased expression of GNAI2 protein CTD PMID:8419537 PMID:11264240 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979 		JBrowse link
G Gnai3 G protein subunit alpha i3 increases expression EXP Reserpine results in increased expression of GNAI3 protein CTD PMID:11264240 NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742 		JBrowse link
G Gnao1 G protein subunit alpha o1 increases expression EXP Reserpine results in increased expression of GNAO1 mRNA; Reserpine results in increased expression of GNAO1 protein CTD PMID:8419537 PMID:11264240 NCBI chr19:11,034,874...11,192,531
Ensembl chr19:11,035,956...11,192,493 		JBrowse link
G Gnas GNAS complex locus increases expression
decreases expression 		EXP Reserpine results in increased expression of GNAS mRNA; Reserpine results in increased expression of GNAS protein
Reserpine results in decreased expression of GNAS protein alternative form 		CTD PMID:1336118 PMID:8419537 PMID:11264240 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262 		JBrowse link
G Grm5 glutamate metabotropic receptor 5 decreases expression
increases expression 		EXP Reserpine results in decreased expression of GRM5 mRNA
Reserpine results in increased expression of GRM5 protein 		CTD PMID:16890937 NCBI chr 1:141,310,069...141,884,980
Ensembl chr 1:141,312,368...141,882,274 		JBrowse link
G Hgf hepatocyte growth factor increases expression EXP Reserpine results in increased expression of HGF protein CTD PMID:16081063 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hspg2 heparan sulfate proteoglycan 2 multiple interactions ISO HSPG2 gene results in increased susceptibility to [Haloperidol co-treated with Reserpine] CTD PMID:20072119 NCBI chr 5:149,677,437...149,778,594
Ensembl chr 5:149,677,476...149,778,594 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A decreases expression ISO Reserpine results in decreased expression of HTR1A protein CTD PMID:26114099 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Iapp islet amyloid polypeptide multiple interactions EXP IAPP protein inhibits the reaction [Reserpine results in decreased expression of BCL2 protein]; IAPP protein inhibits the reaction [Reserpine results in increased activity of CASP3 protein]; IAPP protein inhibits the reaction [Reserpine results in increased activity of CASP8 protein]; IAPP protein inhibits the reaction [Reserpine results in increased expression of BAX protein]; IAPP protein inhibits the reaction [Reserpine results in increased expression of TNFSF10 protein] CTD PMID:19463876 NCBI chr 4:175,237,107...175,244,373
Ensembl chr 4:175,237,115...175,242,920 		JBrowse link
G Il10 interleukin 10 decreases expression
multiple interactions 		ISO Reserpine results in decreased expression of IL10 mRNA; Reserpine results in decreased expression of IL10 protein
SCH 23390 inhibits the reaction [Reserpine results in decreased expression of IL10 mRNA]; SCH 23390 inhibits the reaction [Reserpine results in decreased expression of IL10 protein] 		CTD PMID:16985181 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il18 interleukin 18 increases expression EXP Reserpine results in increased expression of IL18 mRNA CTD PMID:8999896 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP Reserpine results in increased expression of JUN mRNA CTD PMID:1359376 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Reserpine promotes the reaction [Dextroamphetamine results in increased expression of JUNB mRNA]; SCH 23390 inhibits the reaction [Reserpine promotes the reaction [Dextroamphetamine results in increased expression of JUNB mRNA]] CTD PMID:1347779 NCBI chr19:40,081,126...40,082,910
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Kcna3 potassium voltage-gated channel subfamily A member 3 decreases activity
multiple interactions 		ISO Reserpine results in decreased activity of KCNA3 protein
[Reserpine results in decreased activity of KCNA3 protein] which results in decreased import of Thallium 		CTD PMID:21362439 NCBI chr 2:194,632,106...194,634,059
Ensembl chr 2:194,632,196...194,650,138 		JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 increases expression EXP Reserpine results in increased expression of KCNA5 mRNA CTD PMID:12606256 NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697 		JBrowse link
G Kcnd2 potassium voltage-gated channel subfamily D member 2 decreases expression EXP Reserpine results in decreased expression of KCND2 mRNA CTD PMID:12606256 NCBI chr 4:49,775,812...50,277,746
Ensembl chr 4:49,776,246...50,277,728 		JBrowse link
G Kcnd3 potassium voltage-gated channel subfamily D member 3 decreases expression EXP Reserpine results in decreased expression of KCND3 mRNA CTD PMID:12606256 NCBI chr 2:192,937,950...193,155,345
Ensembl chr 2:192,937,950...193,155,345 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity
multiple interactions 		ISO Reserpine results in decreased activity of KCNH2 protein
[Reserpine results in decreased activity of KCNH2 protein] which results in decreased import of Thallium 		CTD PMID:21362439 PMID:28551711 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Lep leptin increases expression ISO Reserpine results in increased expression of LEP mRNA CTD PMID:10050748 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases response to substance
decreases expression 		ISO MYC protein results in increased susceptibility to Reserpine
Reserpine results in decreased expression of MYC protein 		CTD PMID:8093862 PMID:19607803 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 increases expression EXP Reserpine results in increased expression of NCF1 mRNA; Reserpine results in increased expression of NCF1 protein CTD PMID:20964730 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases activity ISO Reserpine results in decreased activity of NFE2L2 protein CTD PMID:30203046 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Ngf nerve growth factor increases expression EXP Reserpine results in increased expression of NGF mRNA; Reserpine results in increased expression of NGF protein CTD PMID:1996081 PMID:8593794 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nos1 nitric oxide synthase 1 increases expression EXP Reserpine results in increased expression of NOS1 mRNA; Reserpine results in increased expression of NOS1 protein CTD PMID:7533141 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Npy neuropeptide Y multiple interactions
decreases expression
increases expression 		EXP Chlorisondamine inhibits the reaction [Reserpine results in increased expression of NPY mRNA]; Chlorisondamine promotes the reaction [Reserpine results in increased expression of NPY mRNA]; Dexamethasone inhibits the reaction [Reserpine results in increased expression of NPY mRNA]
Reserpine results in decreased expression of NPY mRNA; Reserpine results in decreased expression of NPY protein
Reserpine results in increased expression of NPY mRNA; Reserpine results in increased expression of NPY protein 		CTD PMID:1671012 PMID:1676830 PMID:1687976 PMID:1698642 PMID:1713314 More... NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [Reserpine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:17041008 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
decreases activity 		ISO [Reserpine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA
Reserpine results in decreased activity of NR1I3 protein 		CTD PMID:17041008 PMID:30203046 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases expression EXP Reserpine results in increased expression of NR3C1 mRNA CTD PMID:7984052 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions
decreases expression 		ISO arsenic trioxide promotes the reaction [Reserpine results in decreased expression of NTRK2 protein] CTD PMID:26114099 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Nts neurotensin increases expression EXP Reserpine results in increased expression of NTS mRNA CTD PMID:1850078 NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423 		JBrowse link
G Odc1 ornithine decarboxylase 1 decreases expression
multiple interactions 		EXP
ISO 		Reserpine results in decreased expression of ODC1 protein
Reserpine inhibits the reaction [CB 3717 results in increased activity of ODC1 protein]; Reserpine inhibits the reaction [CB 3717 results in increased expression of ODC1 mRNA]; Reserpine inhibits the reaction [Testosterone results in increased activity of ODC1 protein]; Reserpine inhibits the reaction [Testosterone results in increased expression of ODC1 mRNA] 		CTD PMID:6519379 PMID:9194572 PMID:10354516 PMID:17371283 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Pam peptidylglycine alpha-amidating monooxygenase increases expression EXP Reserpine results in increased expression of PAM mRNA CTD PMID:8189248 NCBI chr 9:97,998,581...98,271,966
Ensembl chr 9:98,122,916...98,271,965 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of PCNA protein CTD PMID:11318962 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 increases expression EXP Reserpine results in increased expression of PCSK2 mRNA CTD PMID:8189248 NCBI chr 3:130,880,422...131,183,127
Ensembl chr 3:130,880,422...131,183,127 		JBrowse link
G Penk proenkephalin multiple interactions
decreases expression
increases expression 		EXP Apomorphine inhibits the reaction [Reserpine results in increased expression of PENK mRNA]
Reserpine results in decreased expression of PENK mRNA
Reserpine results in increased expression of PENK mRNA; Reserpine results in increased expression of PENK protein 		CTD PMID:1331675 PMID:1850078 PMID:3188958 PMID:3838946 PMID:4078631 More... NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129 		JBrowse link
G Pnmt phenylethanolamine-N-methyltransferase multiple interactions
decreases expression
increases expression 		EXP Chlorisondamine inhibits the reaction [Reserpine results in decreased expression of PNMT mRNA]; Dexamethasone inhibits the reaction [Reserpine results in decreased expression of PNMT mRNA]; POMC protein alternative form inhibits the reaction [Reserpine results in decreased expression of PNMT mRNA]; Reserpine results in increased expression of and results in increased activity of PNMT protein
Reserpine results in increased expression of PNMT mRNA 		CTD PMID:1359376 PMID:1687976 PMID:1714554 PMID:2903502 PMID:8063705 More... NCBI chr10:83,383,019...83,386,557
Ensembl chr10:83,384,923...83,386,556 		JBrowse link
G Pomc proopiomelanocortin increases expression
multiple interactions 		EXP Reserpine results in increased expression of POMC mRNA; Reserpine results in increased expression of POMC protein alternative form
POMC protein alternative form inhibits the reaction [Reserpine results in decreased expression of PNMT mRNA] 		CTD PMID:8479280 PMID:20504635 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha decreases expression ISO Reserpine results in decreased expression of PRKACA protein CTD PMID:26114099 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430 		JBrowse link
G Prl prolactin increases expression EXP Reserpine results in increased expression of PRL protein CTD PMID:11071396 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Prss1 serine protease 1 decreases expression
increases expression 		EXP Reserpine results in decreased expression of PRSS1 protein
Reserpine results in increased expression of PRSS1 protein 		CTD PMID:8625754 NCBI chr 4:70,364,589...70,367,792
Ensembl chr 4:70,364,586...70,367,792 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression EXP Reserpine results in increased expression of PTGS2 protein CTD PMID:16081063 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pts 6-pyruvoyl-tetrahydropterin synthase increases expression EXP Reserpine results in increased expression of PTS mRNA CTD PMID:7545485 NCBI chr 8:50,870,838...50,877,869
Ensembl chr 8:50,870,841...50,877,869 		JBrowse link
G Rasd2 RASD family, member 2 decreases expression EXP Reserpine results in decreased expression of RASD2 mRNA CTD PMID:16352400 NCBI chr19:13,594,291...13,605,016
Ensembl chr19:13,594,291...13,605,016 		JBrowse link
G Rgs10 regulator of G-protein signaling 10 decreases expression EXP Reserpine results in decreased expression of RGS10 mRNA CTD PMID:14505795 NCBI chr 1:192,376,772...192,422,640
Ensembl chr 1:182,946,336...182,987,697 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 decreases expression EXP Reserpine results in decreased expression of RGS2 mRNA CTD PMID:14505795 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 decreases expression EXP Reserpine results in decreased expression of RGS4 mRNA CTD PMID:14505795 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068 		JBrowse link
G Rgs5 regulator of G-protein signaling 5 decreases expression EXP Reserpine results in decreased expression of RGS5 mRNA CTD PMID:14505795 NCBI chr13:81,848,254...81,885,053
Ensembl chr13:81,836,304...81,885,518 		JBrowse link
G Rgs8 regulator of G-protein signaling 8 decreases expression EXP Reserpine results in decreased expression of RGS8 mRNA CTD PMID:14505795 NCBI chr13:65,804,703...65,848,955
Ensembl chr13:65,804,797...65,846,807 		JBrowse link
G Rgs9 regulator of G-protein signaling 9 affects response to substance
decreases expression 		ISO
EXP 		RGS9 affects the susceptibility to Reserpine
Reserpine results in decreased expression of RGS9 mRNA 		CTD PMID:14505795 PMID:15728856 NCBI chr10:94,195,265...94,270,892
Ensembl chr10:94,197,054...94,270,892 		JBrowse link
G Scg2 secretogranin II increases expression EXP Reserpine results in increased expression of SCG2 mRNA CTD PMID:1907749 PMID:8189248 PMID:8361347 NCBI chr 9:80,803,074...80,808,646
Ensembl chr 9:80,803,075...80,821,097 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions EXP [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of SERPINE1 mRNA; [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of SERPINE1 protein CTD PMID:11318962 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Siah1 siah E3 ubiquitin protein ligase 1 increases expression ISO Reserpine results in increased expression of SIAH1 mRNA CTD PMID:19607803 NCBI chr19:36,552,165...36,575,773
Ensembl chr19:20,378,439...20,403,808 		JBrowse link
G Slc18a1 solute carrier family 18 member A1 decreases activity
multiple interactions 		ISO Reserpine results in decreased activity of SLC18A1 protein
Reserpine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin] 		CTD PMID:8245983 PMID:21712771 NCBI chr16:20,653,268...20,687,051
Ensembl chr16:20,653,508...20,687,051 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 affects binding
decreases response to substance
decreases activity
multiple interactions
affects response to substance
increases expression 		ISO
EXP 		Reserpine binds to SLC18A2 protein
SLC18A2 gene SNP results in decreased susceptibility to Reserpine
Reserpine results in decreased activity of SLC18A2 protein
Reserpine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Serotonin inhibits the reaction [SLC18A2 protein binds to Reserpine]
SLC18A2 affects the susceptibility to Reserpine
Reserpine results in increased expression of SLC18A2 mRNA
Reserpine inhibits the reaction [SLC18A2 protein results in increased uptake of Dopamine] 		CTD PMID:1438304 PMID:7912402 PMID:8189248 PMID:9038139 PMID:15475732 More... NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325 		JBrowse link
G Slc6a2 solute carrier family 6 member 2 decreases expression EXP Reserpine results in decreased expression of SLC6A2 mRNA CTD PMID:7478180 PMID:7616203 NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 decreases activity
affects response to substance 		ISO Reserpine results in decreased activity of SLC6A3 protein
SLC6A3 gene mutant form affects the susceptibility to Reserpine 		CTD PMID:17664021 PMID:19615345 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 decreases expression EXP Reserpine results in decreased expression of SLC6A4 mRNA CTD PMID:10027743 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384 		JBrowse link
G Snca synuclein alpha affects response to substance
multiple interactions
increases expression 		ISO
EXP 		SNCA protein mutant form affects the susceptibility to Reserpine
[Levodopa co-treated with Carbidopa] inhibits the reaction [Reserpine results in increased expression of SNCA protein]; Dextromethorphan promotes the reaction [zolmitriptan inhibits the reaction [Reserpine results in increased expression of SNCA protein]]; Glutamic Acid inhibits the reaction [zolmitriptan inhibits the reaction [Reserpine results in increased expression of SNCA protein]]; zolmitriptan inhibits the reaction [Reserpine results in increased expression of SNCA protein] 		CTD PMID:18622040 PMID:38229316 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO Reserpine results in increased expression of SQSTM1 mRNA CTD PMID:26198647 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Syt7 synaptotagmin 7 multiple interactions EXP [Reserpine co-treated with Apomorphine] results in increased expression of SYT7 mRNA CTD PMID:17719177 NCBI chr 1:207,031,359...207,093,787
Ensembl chr 1:207,031,592...207,089,026 		JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions
increases expression 		EXP [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Reserpine co-treated with Quinpirole] results in increased expression of TAC1 mRNA; [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Reserpine] results in increased expression of TAC1 mRNA; Apomorphine promotes the reaction [Reserpine results in increased expression of TAC1 mRNA] CTD PMID:9751140 PMID:17719177 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tff1 trefoil factor 1 increases expression ISO Reserpine results in increased expression of TFF1 mRNA CTD PMID:35307500 NCBI chr20:9,237,095...9,240,956
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Th tyrosine hydroxylase increases expression
multiple interactions
increases stability
affects activity
decreases expression
increases activity 		ISO
EXP 		Reserpine results in increased expression of TH mRNA
Bicuculline promotes the reaction [Reserpine affects the activity of TH protein]; Bicuculline promotes the reaction [Reserpine results in increased expression of TH mRNA]; Chlorisondamine inhibits the reaction [Reserpine results in increased expression of TH mRNA]; Chlorisondamine promotes the reaction [Reserpine results in increased expression of TH mRNA]; Desipramine inhibits the reaction [Reserpine results in increased expression of TH mRNA]; Reserpine promotes the reaction [CREM protein binds to TH promoter]; Reserpine results in increased expression of and results in increased activity of TH protein
Reserpine results in increased stability of TH mRNA
Reserpine results in decreased expression of TH mRNA
Reserpine results in increased expression of TH mRNA; Reserpine results in increased expression of TH protein
Reserpine results in increased activity of TH protein 		CTD PMID:1350653 PMID:1359376 PMID:1676830 PMID:1687822 PMID:1687976 More... NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions 		EXP Reserpine results in increased expression of TNF protein
cerebrolysin inhibits the reaction [Reserpine results in increased expression of TNF protein]; Fluoxetine inhibits the reaction [Reserpine results in increased expression of TNF protein] 		CTD PMID:33279466 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions
increases expression 		EXP IAPP protein inhibits the reaction [Reserpine results in increased expression of TNFSF10 protein] CTD PMID:19463876 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Tph1 tryptophan hydroxylase 1 increases activity
decreases activity 		EXP Reserpine results in increased activity of TPH1 protein
Reserpine results in decreased activity of TPH1 protein 		CTD PMID:8369965 NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344 		JBrowse link
G Vgf VGF nerve growth factor inducible increases expression EXP Reserpine results in increased expression of VGF mRNA CTD PMID:8189248 NCBI chr12:19,637,313...19,645,123
Ensembl chr12:19,637,320...19,640,341 		JBrowse link
G Vip vasoactive intestinal peptide increases expression EXP Reserpine results in increased expression of VIP mRNA CTD PMID:1850078 NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20845
    role 20805
      biological role 20803
        xenobiotic 19508
          reserpine 120
Path 2
Term Annotations click to browse term
  CHEBI ontology 20845
    subatomic particle 20843
      composite particle 20843
        hadron 20843
          baryon 20843
            nucleon 20843
              atomic nucleus 20843
                atom 20843
                  main group element atom 20766
                    p-block element atom 20766
                      carbon group element atom 20699
                        carbon atom 20693
                          organic molecular entity 20693
                            heteroorganic entity 20202
                              organonitrogen compound 19382
                                alkaloid 8055
                                  indole alkaloid 1997
                                    terpenoid indole alkaloid 1503
                                      monoterpenoid indole alkaloid 1485
                                        yohimban alkaloid 159
                                          reserpic acid 120
                                            reserpine 120
paths to the root